|
Name |
Accession |
Description |
Interval |
E-value |
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
412-634 |
1.62e-162 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 498.42 E-value: 1.62e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILT 491
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTP 571
Cdd:cd18003 81 YYGSAKERKLKRQGWMKPNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTP 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1831511703 572 LQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEFNAPLIGRLHKVLRPFILRR 634
Cdd:cd18003 161 LQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPLTAMSEGSQEENEELVRRLHKVLRPFLLRR 223
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
415-701 |
6.07e-101 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 326.18 E-value: 6.07e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 415 YQMVGLDWMVTLYEK-NLNGILADEMGLGKTIQTISLLAHMACSESIWG-PHLIVVPTSVILNWEMEFKKWC--PALKIL 490
Cdd:pfam00176 1 YQIEGVNWMLSLENNlGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGgPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 491 TYFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGT 570
Cdd:pfam00176 81 VLHGNKRPQERWKNDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 571 PLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTgmmEGNMEfnaPLIGRLHKVLRPFILRRLKKEVEKQLPEKTEHI 650
Cdd:pfam00176 161 PLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIE---RGGGK---KGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYI 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1831511703 651 VNCSLSKRQRYLYDDFMSRRSTKE----NLKSGNMMSVLNIVMQLRKCCNHPNLF 701
Cdd:pfam00176 235 LFCRLSKLQRKLYQTFLLKKDLNAiktgEGGREIKASLLNILMRLRKICNHPGLI 289
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
347-701 |
4.23e-96 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 327.18 E-value: 4.23e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 347 AEDGNGDGHGVLENVDYVKLNSQDSDERQQELANIAEEALKFQPKGYTLETTQVKT---PVPFLIRGQLREYQMVGLDWM 423
Cdd:COG0553 174 ALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAFRLRRLREaleSLPAGLKATLRPYQLEGAAWL 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 424 VTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIwGPHLIVVPTSVILNWEMEFKKWCPALKILTYFGTaKERAEKR 503
Cdd:COG0553 254 LFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLA-RPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGT-RERAKGA 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 504 KGWMKpncFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLM 583
Cdd:COG0553 332 NPFED---ADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLL 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 584 HFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEfnapligRLHKVLRPFILRRLKKEVEKQLPEKTEHIVNCSLSKRQRYLY 663
Cdd:COG0553 409 DFLNPGLLGSLKAFRERFARPIEKGDEEALE-------RLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALY 481
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1831511703 664 DDFMS--RRSTKENLKSGNMMSVLNIVMQLRKCCNHPNLF 701
Cdd:COG0553 482 EAVLEylRRELEGAEGIRRRGLILAALTRLRQICSHPALL 521
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
226-705 |
3.36e-93 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 327.91 E-value: 3.36e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 226 EEFKAPGSDSESDDEQTIANAEKSQKKEDvRQEVDALQNEATVDMDDflytlppeylKAYGLTQEDLEEMKREKLEEQKA 305
Cdd:PLN03142 2 EEQVNTQANEEEDEEELEAVARSAGSDSD-DDEVPAEDEDEDEEDDE----------EAESPAKAEISKREKARLKELKK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 306 RKEacgDNEEKMEIDESPSSDAQKPSTSSSDLT------------AEQLQDPTAEDGNGDGHGVlenvdyVKLNSQDSDE 373
Cdd:PLN03142 71 QKK---QEIQKILEQQNAAIDADMNNKGKGRLKyllqqteifahfAKGDQSASAKKAKGRGRHA------SKLTEEEEDE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 374 rqqELANIAEEALkfQPKGYTLETTQvktpvPFLIRGQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAH 453
Cdd:PLN03142 142 ---EYLKEEEDGL--GGSGGTRLLVQ-----PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 454 MACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILTYFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRA 533
Cdd:PLN03142 212 LHEYRGITGPHMVVAPKSTLGNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVAGKFDVCVTSFEMAIKEKTALKRFS 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 534 WQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNpltgmmeGNM 613
Cdd:PLN03142 292 WRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQI-------SGE 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 614 EFNAPLIGRLHKVLRPFILRRLKKEVEKQLPEKTEHIVNCSLSKRQRYLYDDFMSRRSTKENlKSGNMMSVLNIVMQLRK 693
Cdd:PLN03142 365 NDQQEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLDVVN-AGGERKRLLNIAMQLRK 443
|
490
....*....|....*
gi 1831511703 694 CCNHPNLF---EPRP 705
Cdd:PLN03142 444 CCNHPYLFqgaEPGP 458
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
1037-1166 |
2.91e-59 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 200.40 E-value: 2.91e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1037 IEYD-CGKLQTLAVLLRQLYLYKHRCLIFTQMSKMLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNADPKVFCFIL 1115
Cdd:cd18793 5 IEEVvSGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLL 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1831511703 1116 STRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLI 1166
Cdd:cd18793 85 STKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
1022-1191 |
1.12e-49 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 189.67 E-value: 1.12e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1022 RMSISRALQFPELRLIEYDCGKLQTLAVLLRQLYLYKHRCLIFTQMSKMLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMM 1101
Cdd:COG0553 513 QICSHPALLLEEGAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELV 592
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1102 ERFNADPKVFCFILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLISERTIEENILRKATQ 1181
Cdd:COG0553 593 DRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEE 672
|
170
....*....|
gi 1831511703 1182 KRRLGELAID 1191
Cdd:COG0553 673 KRALAESVLG 682
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
1036-1192 |
9.66e-45 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 178.07 E-value: 9.66e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1036 LIEyDCGKLQTLAVLLRQLYLYKHRCLIFTQMSKMLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNAD-PKVFCFI 1114
Cdd:PLN03142 466 LVE-NSGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPgSEKFVFL 544
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831511703 1115 LSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLISERTIEENILRKATQKRRLGELAIDE 1192
Cdd:PLN03142 545 LSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQ 622
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
411-600 |
2.06e-29 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 117.59 E-value: 2.06e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 411 QLREYQMVGLDWMvtlYEKNLNGILADEMGLGKTIQtISLLAHMACSESIWGPHLIVVPT-SVILNWEMEFKKWCP--AL 487
Cdd:smart00487 8 PLRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLA-ALLPALEALKRGKGGRVLVLVPTrELAEQWAEELKKLGPslGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 488 KILTYFGTAKERAEKRKgwMKPNCFHVCITSYKTVTQDIR--AFKQRAWQYLILDEAQNIKNWK-SQRWQALLNV--RAR 562
Cdd:smart00487 84 KVVGLYGGDSKREQLRK--LESGKTDILVTTPGRLLDLLEndKLSLSNVDLVILDEAHRLLDGGfGDQLEKLLKLlpKNV 161
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1831511703 563 RRLLLTGTPLQNSLMELWSLMH--FLMPTIFSSHDDFKDW 600
Cdd:smart00487 162 QLLLLSATPPEEIENLLELFLNdpVFIDVGFTPLEPIEQF 201
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
1042-1155 |
4.54e-27 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 107.30 E-value: 4.54e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1042 GKLQTLAVLLRQLYlyKHRCLIFTQMSKMLDvLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNADPkvFCFILSTRSGG 1121
Cdd:pfam00271 1 EKLEALLELLKKER--GGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGK--IDVLVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 1831511703 1122 VGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIG 1155
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1072-1155 |
5.47e-22 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 91.89 E-value: 5.47e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1072 DVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNADPKVFcfILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRC 1151
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKV--LVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 1831511703 1152 HRIG 1155
Cdd:smart00490 79 GRAG 82
|
|
| HSA |
pfam07529 |
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. ... |
85-149 |
8.34e-17 |
|
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. This region does not form a compact domain in the known structures.
Pssm-ID: 462194 [Multi-domain] Cd Length: 67 Bit Score: 76.46 E-value: 8.34e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831511703 85 VEPER-NKTHWDYLLEEVKWMAVDFRTETNTKRKIAKVIAHAIAKQHRDKQIEIERAAEREIKEKR 149
Cdd:pfam07529 2 DEPERrEKTHHDYLLEEILWHSKDFKQERRWKRARAKKLARAVAQYHKNIEKEEQKRIEREEKQRL 67
|
|
| HSA |
smart00573 |
domain in helicases and associated with SANT domains; |
82-151 |
6.23e-14 |
|
domain in helicases and associated with SANT domains;
Pssm-ID: 214727 [Multi-domain] Cd Length: 73 Bit Score: 68.58 E-value: 6.23e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 82 PKCVEPERNKTHWDYLLEEVKWMAVDFRTETNTKRKIAKVIAHAIAKQHRDKQIEIERAAEREikEKRKM 151
Cdd:smart00573 1 QKLEEERRRKQHWDHLLEEMIWHAKDFKEEHKWKIAAAKKMAKAVMDYHQNKEKEEERREEKN--EKRRL 68
|
|
| DISARM_DrmD_b |
NF038318 |
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component ... |
1094-1169 |
2.06e-06 |
|
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component of class 1 DISARM (Defence Island System Associated with Restriction Modification), which contains a DNA adenine N6 methyltransferase. This HMM describes a distinct form that is somewhat shorter than the majority of DrmD proteins.
Pssm-ID: 468472 [Multi-domain] Cd Length: 868 Bit Score: 53.15 E-value: 2.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1094 VEQRQAMMERFNADPKVfcfILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQ-----------TRNVS- 1161
Cdd:NF038318 473 VEYKHAIVDYFKNNAKI---LIVTDAGSEGLNLQFCNTVINYDLPWNPQKIEQRIGRCHRYGQkndvvainllnTQNVAd 549
|
90
....*....|
gi 1831511703 1162 --IYRLISER 1169
Cdd:NF038318 550 krVYEILSEK 559
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
53-329 |
6.08e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.52 E-value: 6.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 53 VERAAKREAHVLARIAELRKNGLWSNSRLPKCVEPERNKTHWDYLLEEVKWMAVDFRTETNTKRKIAKViahaiaKQHRD 132
Cdd:PTZ00121 1557 LKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEEL------KKAEE 1630
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 133 KQIEIERAAEREIKEKRKmcagiAKMVRdfwsstdkvvdiraKEVLESRLRKARNKHlmfvigqvdemsnivqeglvsss 212
Cdd:PTZ00121 1631 EKKKVEQLKKKEAEEKKK-----AEELK--------------KAEEENKIKAAEEAK----------------------- 1668
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 213 kspsIASDRDDKDEEFKAPGSDSESDDEQTIANAEKSQKKEDVRQEVDALQNEATvdmddflytlppEYLKAYGLTQEDL 292
Cdd:PTZ00121 1669 ----KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAE------------ELKKAEEENKIKA 1732
|
250 260 270
....*....|....*....|....*....|....*..
gi 1831511703 293 EEMKREKLEEQKARKEACGDNEEKMEIDESPSSDAQK 329
Cdd:PTZ00121 1733 EEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKK 1769
|
|
| MDN1 |
COG5271 |
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ... |
222-379 |
3.93e-03 |
|
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444083 [Multi-domain] Cd Length: 1028 Bit Score: 42.69 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 222 DDKDEEFKAPGSDSESDDEQTIANAEKSQKKEDVRQEVDALQNEATVDMDDFLYTLPPEYLKAYGLTQEDLEEMKRE-KL 300
Cdd:COG5271 538 DETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAETEDATENADADETEESADESEEAEASEDEAAEEEEADDDEaDA 617
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831511703 301 EEQKARKEACGDNEEKMEIDESPSSDAQKPSTSSSDLTAEqlqDPTAEDGNGDghgvlENVDYVKLNSQDSDERQQELA 379
Cdd:COG5271 618 DADGAADEEETEEEAAEDEAAEPETDASEAADEDADAETE---AEASADESEE-----EAEDESETSSEDAEEDADAAA 688
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
1832-2213 |
5.71e-03 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 41.92 E-value: 5.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1832 IQHLQSSSTGLGSQQNLQNSHNSEQRNNVQNMHQNQYNSSQN--------------PPIPIRQIGA-------ASSHQHD 1890
Cdd:pfam09606 47 ILHVRDMSKKAAQQQQPQGGQGNGGMGGGQQGMPDPINALQNlagqgtrpqmmgpmGPGPGGPMGQqmggpgtASNLLAS 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1891 QGS----QGPGGKPQAYHLVQQGSQ------QQQQQQQQATLQRRNAAAAAGSNVQFIQQQQQQQQSGKNCGQ--GQSFV 1958
Cdd:pfam09606 127 LGRpqmpMGGAGFPSQMSRVGRMQPggqaggMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQmpPQMGV 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1959 VMGSQSSSNDGQGGASTVGGGGGGSQQPHQQQQQQPQQRIQYIPQVTGSGNNGGGGGRGGygstlvMPRGGRVVRPAGtL 2038
Cdd:pfam09606 207 PGMPGPADAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQSQLGMGINQMQQ------MPQGVGGGAGQG-G 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 2039 PGGGRLYVDHNRHPYP--MSSNVVPVRVLPATQQGQQRMmtGQRRPAPAPGTVAAMVLPNRGAGGIPQMRSLQRGSYTGG 2116
Cdd:pfam09606 280 PGQPMGPPGQQPGAMPnvMSIGDQNNYQQQQTRQQQQQQ--GGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNF 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 2117 GGQQrINVMVQpqqmrsnngggvggqgglqggpggpqgirrplvGRPLQRGVDNQAPTVAQVVVAPPQGMQQASQgppvl 2196
Cdd:pfam09606 358 GGLG-ANPMQR---------------------------------GQPGMMSSPSPVPGQQVRQVTPNQFMRQSPQ----- 398
|
410
....*....|....*..
gi 1831511703 2197 hmQRAVSMQMPTSHHHQ 2213
Cdd:pfam09606 399 --PSVPSPQGPGSQPPQ 413
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
412-634 |
1.62e-162 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 498.42 E-value: 1.62e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILT 491
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTP 571
Cdd:cd18003 81 YYGSAKERKLKRQGWMKPNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTP 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1831511703 572 LQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEFNAPLIGRLHKVLRPFILRR 634
Cdd:cd18003 161 LQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPLTAMSEGSQEENEELVRRLHKVLRPFLLRR 223
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
415-701 |
6.07e-101 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 326.18 E-value: 6.07e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 415 YQMVGLDWMVTLYEK-NLNGILADEMGLGKTIQTISLLAHMACSESIWG-PHLIVVPTSVILNWEMEFKKWC--PALKIL 490
Cdd:pfam00176 1 YQIEGVNWMLSLENNlGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGgPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 491 TYFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGT 570
Cdd:pfam00176 81 VLHGNKRPQERWKNDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 571 PLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTgmmEGNMEfnaPLIGRLHKVLRPFILRRLKKEVEKQLPEKTEHI 650
Cdd:pfam00176 161 PLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIE---RGGGK---KGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYI 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1831511703 651 VNCSLSKRQRYLYDDFMSRRSTKE----NLKSGNMMSVLNIVMQLRKCCNHPNLF 701
Cdd:pfam00176 235 LFCRLSKLQRKLYQTFLLKKDLNAiktgEGGREIKASLLNILMRLRKICNHPGLI 289
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
347-701 |
4.23e-96 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 327.18 E-value: 4.23e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 347 AEDGNGDGHGVLENVDYVKLNSQDSDERQQELANIAEEALKFQPKGYTLETTQVKT---PVPFLIRGQLREYQMVGLDWM 423
Cdd:COG0553 174 ALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAFRLRRLREaleSLPAGLKATLRPYQLEGAAWL 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 424 VTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIwGPHLIVVPTSVILNWEMEFKKWCPALKILTYFGTaKERAEKR 503
Cdd:COG0553 254 LFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLA-RPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGT-RERAKGA 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 504 KGWMKpncFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLM 583
Cdd:COG0553 332 NPFED---ADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLL 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 584 HFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEfnapligRLHKVLRPFILRRLKKEVEKQLPEKTEHIVNCSLSKRQRYLY 663
Cdd:COG0553 409 DFLNPGLLGSLKAFRERFARPIEKGDEEALE-------RLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALY 481
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1831511703 664 DDFMS--RRSTKENLKSGNMMSVLNIVMQLRKCCNHPNLF 701
Cdd:COG0553 482 EAVLEylRRELEGAEGIRRRGLILAALTRLRQICSHPALL 521
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
226-705 |
3.36e-93 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 327.91 E-value: 3.36e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 226 EEFKAPGSDSESDDEQTIANAEKSQKKEDvRQEVDALQNEATVDMDDflytlppeylKAYGLTQEDLEEMKREKLEEQKA 305
Cdd:PLN03142 2 EEQVNTQANEEEDEEELEAVARSAGSDSD-DDEVPAEDEDEDEEDDE----------EAESPAKAEISKREKARLKELKK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 306 RKEacgDNEEKMEIDESPSSDAQKPSTSSSDLT------------AEQLQDPTAEDGNGDGHGVlenvdyVKLNSQDSDE 373
Cdd:PLN03142 71 QKK---QEIQKILEQQNAAIDADMNNKGKGRLKyllqqteifahfAKGDQSASAKKAKGRGRHA------SKLTEEEEDE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 374 rqqELANIAEEALkfQPKGYTLETTQvktpvPFLIRGQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAH 453
Cdd:PLN03142 142 ---EYLKEEEDGL--GGSGGTRLLVQ-----PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 454 MACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILTYFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRA 533
Cdd:PLN03142 212 LHEYRGITGPHMVVAPKSTLGNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVAGKFDVCVTSFEMAIKEKTALKRFS 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 534 WQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNpltgmmeGNM 613
Cdd:PLN03142 292 WRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQI-------SGE 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 614 EFNAPLIGRLHKVLRPFILRRLKKEVEKQLPEKTEHIVNCSLSKRQRYLYDDFMSRRSTKENlKSGNMMSVLNIVMQLRK 693
Cdd:PLN03142 365 NDQQEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLDVVN-AGGERKRLLNIAMQLRK 443
|
490
....*....|....*
gi 1831511703 694 CCNHPNLF---EPRP 705
Cdd:PLN03142 444 CCNHPYLFqgaEPGP 458
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
410-636 |
2.55e-92 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 298.85 E-value: 2.55e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 410 GQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKI 489
Cdd:cd17997 2 GTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 490 LTYFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTG 569
Cdd:cd17997 82 VVLIGDKEERADIIRDVLLPGKFDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTG 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831511703 570 TPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNplTGMMEGNMEfnapLIGRLHKVLRPFILRRLK 636
Cdd:cd17997 162 TPLQNNLHELWALLNFLLPDVFTSSEDFDEWFNV--NNCDDDNQE----VVQRLHKVLRPFLLRRIK 222
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
412-634 |
2.33e-90 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 293.26 E-value: 2.33e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILT 491
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKERAEKRKGWMKPNC------FHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRL 565
Cdd:cd18002 81 YWGNPKDRKVLRKFWDRKNLytrdapFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831511703 566 LLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEFNAPLIGRLHKVLRPFILRR 634
Cdd:cd18002 161 LLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGLNEHQLKRLHMILKPFMLRR 229
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
410-636 |
3.94e-87 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 284.26 E-value: 3.94e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 410 GQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKI 489
Cdd:cd17996 2 GTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 490 LTYFGTAKERAEKRKGwMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLN-VRARRRLLLT 568
Cdd:cd17996 82 IVYKGTPDVRKKLQSQ-IRAGKFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARYRLLLT 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1831511703 569 GTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTGM-----MEGNMEFNAPLIGRLHKVLRPFILRRLK 636
Cdd:cd17996 161 GTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTgeqvkIELNEEETLLIIRRLHKVLRPFLLRRLK 233
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
412-588 |
3.28e-84 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 273.67 E-value: 3.28e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILT 491
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKERAEKRKGWMKPNcFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTP 571
Cdd:cd17919 81 YHGSQRERAQIRAKEKLDK-FDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTP 159
|
170
....*....|....*..
gi 1831511703 572 LQNSLMELWSLMHFLMP 588
Cdd:cd17919 160 LQNNLEELWALLDFLDP 176
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
408-636 |
1.25e-83 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 273.67 E-value: 1.25e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 408 IRGQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMAcSESIWGPHLIVVPTSVILNWEMEFKKWCPAL 487
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRK-EEGRKGPSLVVAPTSLIYNWEEEAAKFAPEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 488 KILTYFGTAKERAEKRKgwMKPNcfHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLL 567
Cdd:cd18012 80 KVLVIHGTKRKREKLRA--LEDY--DLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLAL 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831511703 568 TGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLtgmmegNMEFNAPLIGRLHKVLRPFILRRLK 636
Cdd:cd18012 156 TGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPI------EKDGDEEALEELKKLISPFILRRLK 218
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
410-636 |
1.09e-81 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 268.87 E-value: 1.09e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 410 GQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMAcSESIWGPHLIVVPTSVILNWEMEFKKWCPALKI 489
Cdd:cd18009 2 GVMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLR-ERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 490 LTYFGTAKERAEKRKGWMKPNC----FHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRL 565
Cdd:cd18009 81 LLYHGTKEERERLRKKIMKREGtlqdFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831511703 566 LLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSnpLTGMMEGNMEFNAP-------LIGRLHKVLRPFILRRLK 636
Cdd:cd18009 161 LLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFD--FSSLSDNAADISNLseereqnIVHMLHAILKPFLLRRLK 236
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
410-646 |
3.63e-72 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 241.88 E-value: 3.63e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 410 GQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKI 489
Cdd:cd18064 14 GKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 490 LTYFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTG 569
Cdd:cd18064 94 VCLIGDKDQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTG 173
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831511703 570 TPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNpltgmmeGNMEFNAPLIGRLHKVLRPFILRRLKKEVEKQLPEK 646
Cdd:cd18064 174 TPLQNNLHELWALLNFLLPDVFNSAEDFDSWFDT-------NNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPK 243
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
411-634 |
3.35e-69 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 232.25 E-value: 3.35e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 411 QLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKIL 490
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 491 TYFGTAKERAEKRK-GWM----KPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRL 565
Cdd:cd17993 81 VYLGDIKSRDTIREyEFYfsqtKKLKFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831511703 566 LLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSnpltgmmegnmEFNAPLIGRLHKVLRPFILRR 634
Cdd:cd17993 161 LITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEHD-----------EEQEKGIADLHKELEPFILRR 218
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
410-636 |
1.49e-67 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 228.36 E-value: 1.49e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 410 GQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKI 489
Cdd:cd18065 14 GTLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 490 LTYFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTG 569
Cdd:cd18065 94 VCLIGDKDARAAFIRDVMMPGEWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTG 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831511703 570 TPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNpltgmmeGNMEFNAPLIGRLHKVLRPFILRRLK 636
Cdd:cd18065 174 TPLQNNLHELWALLNFLLPDVFNSADDFDSWFDT-------KNCLGDQKLVERLHAVLKPFLLRRIK 233
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
412-591 |
4.17e-65 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 219.18 E-value: 4.17e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMAcSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILT 491
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLK-EIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKERAEKR----KGWMKpncFHVCITSYKTVT---QDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRR 564
Cdd:cd17998 80 YYGSQEERKHLRydilKGLED---FDVIVTTYNLATsnpDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFR 156
|
170 180
....*....|....*....|....*..
gi 1831511703 565 LLLTGTPLQNSLMELWSLMHFLMPTIF 591
Cdd:cd17998 157 LLLTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
397-636 |
1.00e-62 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 214.93 E-value: 1.00e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 397 TTQVKTPVPFLIRGQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNW 476
Cdd:cd18063 9 TERVEKQSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 477 EMEFKKWCPALKILTYFGTAKERaEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQAL 556
Cdd:cd18063 89 TYEFDKWAPSVVKISYKGTPAMR-RSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 557 -LNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNP--LTG-MMEGNMEFNAPLIGRLHKVLRPFIL 632
Cdd:cd18063 168 nTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPfaMTGeRVDLNEEETILIIRRLHKVLRPFLL 247
|
....
gi 1831511703 633 RRLK 636
Cdd:cd18063 248 RRLK 251
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
397-636 |
2.72e-62 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 213.75 E-value: 2.72e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 397 TTQVKTPVPFLIRGQLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNW 476
Cdd:cd18062 9 TEKVEKQSSLLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 477 EMEFKKWCPALKILTYFGTAKERaEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQAL 556
Cdd:cd18062 89 VYEFDKWAPSVVKVSYKGSPAAR-RAFVPQLRSGKFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQVL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 557 -LNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNP--LTG-MMEGNMEFNAPLIGRLHKVLRPFIL 632
Cdd:cd18062 168 nTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPfaMTGeKVDLNEEETILIIRRLHKVLRPFLL 247
|
....
gi 1831511703 633 RRLK 636
Cdd:cd18062 248 RRLK 251
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
412-634 |
4.79e-62 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 212.11 E-value: 4.79e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPaLKILT 491
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGPFLVIAPLSTIPNWQREFETWTD-MNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGT--AKERAEKRK-----GWMKPNC----FHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVR 560
Cdd:cd17995 80 YHGSgeSRQIIQQYEmyfkdAQGRKKKgvykFDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLT 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831511703 561 ARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFsnpltgmmeGNMEfNAPLIGRLHKVLRPFILRR 634
Cdd:cd17995 160 LEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF---------GDLK-TAEQVEKLQALLKPYMLRR 223
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
1037-1166 |
2.91e-59 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 200.40 E-value: 2.91e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1037 IEYD-CGKLQTLAVLLRQLYLYKHRCLIFTQMSKMLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNADPKVFCFIL 1115
Cdd:cd18793 5 IEEVvSGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLL 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1831511703 1116 STRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLI 1166
Cdd:cd18793 85 STKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
412-634 |
9.51e-59 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 202.28 E-value: 9.51e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILT 491
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTP 571
Cdd:cd18006 81 YMGDKEKRLDLQQDIKSTNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTP 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1831511703 572 LQNSLMELWSLMHFLMPTIFSSH--DDFKDWFSNPLTGmmegnmefnAPLIGRLHKVLRPFILRR 634
Cdd:cd18006 161 IQNSLQELYALLSFIEPNVFPKDklDDFIKAYSETDDE---------SETVEELHLLLQPFLLRR 216
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
412-634 |
1.80e-57 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 199.11 E-value: 1.80e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLA--HMACSESIWG---PHLIVVPTSVILNWEMEFKKWCPA 486
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILAsdHHKRANSFNSenlPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 487 --LKILTYFGTAKERAEKRKgwmKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRR 564
Cdd:cd17999 81 afLKPLAYVGPPQERRRLRE---QGEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHR 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1831511703 565 LLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTGMMEGN-----MEFNAPLIGRLHKVLRPFILRR 634
Cdd:cd17999 158 LILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKasakeQEAGALALEALHKQVLPFLLRR 232
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
411-634 |
5.76e-57 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 197.92 E-value: 5.76e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 411 QLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKIL 490
Cdd:cd18054 20 ELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLLVVPLSTLTSWQREFEIWAPEINVV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 491 TYFGTAKERAEKRK-GWMKPNC----FHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRL 565
Cdd:cd18054 100 VYIGDLMSRNTIREyEWIHSQTkrlkFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRL 179
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831511703 566 LLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDwfsnpltgmMEGNMEFNAplIGRLHKVLRPFILRR 634
Cdd:cd18054 180 LITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEE---------DHGKGRENG--YQSLHKVLEPFLLRR 237
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
412-634 |
1.07e-52 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 185.65 E-value: 1.07e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIwGPHLIVVPTSVILNWEMEFKKWCPALKILT 491
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLI-KSVLVVMPTSLIPHWVKEFAKWTPGLRVKV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKERAEKRKGWMKPNcFHVCITSYKTV---TQDIRAF--KQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLL 566
Cdd:cd18001 80 FHGTSKKERERNLERIQRG-GGVLLTTYGMVlsnTEQLSADdhDEFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRII 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831511703 567 LTGTPLQNSLMELWSLMHFLMP-TIFSSHDDFKDWFSNPLTGMMEGNMEFNAPLIGR-----LHKVLRPFILRR 634
Cdd:cd18001 159 LTGTPIQNNLKELWALFDFACNgSLLGTRKTFKMEFENPITRGRDKDATQGEKALGSevaenLRQIIKPYFLRR 232
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
1022-1191 |
1.12e-49 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 189.67 E-value: 1.12e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1022 RMSISRALQFPELRLIEYDCGKLQTLAVLLRQLYLYKHRCLIFTQMSKMLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMM 1101
Cdd:COG0553 513 QICSHPALLLEEGAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELV 592
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1102 ERFNADPKVFCFILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLISERTIEENILRKATQ 1181
Cdd:COG0553 593 DRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEE 672
|
170
....*....|
gi 1831511703 1182 KRRLGELAID 1191
Cdd:COG0553 673 KRALAESVLG 682
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
411-634 |
5.97e-48 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 172.16 E-value: 5.97e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 411 QLREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKIL 490
Cdd:cd18053 20 ELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNAV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 491 TYFGTAKERAEKRKG-WMKPNC----FHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRL 565
Cdd:cd18053 100 VYLGDINSRNMIRTHeWMHPQTkrlkFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRL 179
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831511703 566 LLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNpltGMMEGnmefnaplIGRLHKVLRPFILRR 634
Cdd:cd18053 180 LITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGK---GREYG--------YASLHKELEPFLLRR 237
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
412-634 |
8.00e-48 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 171.70 E-value: 8.00e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLyeknlNGILADEMGLGKTIQTISL-LAHMACSESIWGPH----------------LIVVPTSVIL 474
Cdd:cd18008 1 LLPYQKQGLAWMLPR-----GGILADEMGLGKTIQALALiLATRPQDPKIPEELeenssdpkklylskttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 475 NWEMEFKK--WCPALKILTYFGtaKERAEKRKGWMKpncFHVCITSYKTVTQDIRAFKQRA----------------WQY 536
Cdd:cd18008 76 QWKDEIEKhtKPGSLKVYVYHG--SKRIKSIEELSD---YDIVITTYGTLASEFPKNKKGGgrdskekeasplhrirWYR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 537 LILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEfn 616
Cdd:cd18008 151 VILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKNDRKALE-- 228
|
250
....*....|....*...
gi 1831511703 617 apligRLHKVLRPFILRR 634
Cdd:cd18008 229 -----RLQALLKPILLRR 241
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
412-588 |
1.19e-47 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 169.43 E-value: 1.19e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKIL- 490
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 491 ---TYFGTAKERAEKRKGWMKP------NCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRA 561
Cdd:cd18000 81 lhsSGSGTGSEEKLGSIERKSQlirkvvGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRT 160
|
170 180
....*....|....*....|....*..
gi 1831511703 562 RRRLLLTGTPLQNSLMELWSLMHFLMP 588
Cdd:cd18000 161 PHRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
412-634 |
2.99e-47 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 170.25 E-value: 2.99e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLA--------------------HMACSESIWGPHLIVVPTS 471
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAavlgktgtrrdrennrprfkKKPPASSAKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 472 VILNWEMEFKKWcpalkilTYFGTAK----ERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKN 547
Cdd:cd18005 81 VLYNWKDELDTW-------GHFEVGVyhgsRKDDELEGRLKAGRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 548 WKSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEFNAPLIGR----- 622
Cdd:cd18005 154 PKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRkrkqe 233
|
250
....*....|..
gi 1831511703 623 LHKVLRPFILRR 634
Cdd:cd18005 234 LAVKLSKFFLRR 245
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
412-634 |
3.23e-46 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 165.69 E-value: 3.23e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILT 491
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTakeraekrkgwmkpncfHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTP 571
Cdd:cd17994 81 YVGD-----------------HVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTP 143
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1831511703 572 LQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLtgmmegnmefNAPLIGRLHKVLRPFILRR 634
Cdd:cd17994 144 LQNNLEELFHLLNFLTPERFNNLQGFLEEFADIS----------KEDQIKKLHDLLGPHMLRR 196
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
1036-1192 |
9.66e-45 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 178.07 E-value: 9.66e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1036 LIEyDCGKLQTLAVLLRQLYLYKHRCLIFTQMSKMLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNAD-PKVFCFI 1114
Cdd:PLN03142 466 LVE-NSGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPgSEKFVFL 544
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831511703 1115 LSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRNVSIYRLISERTIEENILRKATQKRRLGELAIDE 1192
Cdd:PLN03142 545 LSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQ 622
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
412-634 |
1.76e-42 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 156.29 E-value: 1.76e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMvtlYE-----KNLNG---ILADEMGLGKTIQTISLLAHMACSESIWGPH----LIVVPTSVILNWEME 479
Cdd:cd18004 1 LRPHQREGVQFL---YDcltgrRGYGGggaILADEMGLGKTLQAIALVWTLLKQGPYGKPTakkaLIVCPSSLVGNWKAE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 480 FKKWCP--ALKILTYFGTAKERAEKRKGWMKPNCFHVCITSYKTVTQDIRAFKQ-RAWQYLILDEAQNIKNWKSQRWQAL 556
Cdd:cd18004 78 FDKWLGlrRIKVVTADGNAKDVKASLDFFSSASTYPVLIISYETLRRHAEKLSKkISIDLLICDEGHRLKNSESKTTKAL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 557 LNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEFNAPLIGR-----LHKVLRPFI 631
Cdd:cd18004 158 NSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAersqeLSELTSRFI 237
|
...
gi 1831511703 632 LRR 634
Cdd:cd18004 238 LRR 240
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
412-634 |
2.01e-40 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 150.16 E-value: 2.01e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILT 491
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKERAEKR-----------KGWMK--------PNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQR 552
Cdd:cd18055 81 YTGDKDSRAIIRenefsfddnavKGGKKafkmkreaQVKFHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 553 WQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPltgmmegnmeFNAPLIGRLHKVLRPFIL 632
Cdd:cd18055 161 FRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADI----------SKEDQIKKLHDLLGPHML 230
|
..
gi 1831511703 633 RR 634
Cdd:cd18055 231 RR 232
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
412-634 |
2.02e-40 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 149.82 E-value: 2.02e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMAcSESIWGPHLIVVPTSVILNWEMEFKKWCpALKILT 491
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVY-NVGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKER---------AEKRKGWMKPNC--FHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVR 560
Cdd:cd18060 79 YHGSLASRqmiqqyemyCKDSRGRLIPGAykFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMD 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831511703 561 ARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTgmmegnmefnAPLIGRLHKVLRPFILRR 634
Cdd:cd18060 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
412-634 |
1.85e-38 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 144.41 E-value: 1.85e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSeSIWGPHLIVVPTSVILNWEMEFKKWCpALKILT 491
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLM-GIRGPFLIIAPLSTITNWEREFRTWT-EMNAIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKERA---------EKRKGWMKPNC--FHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVR 560
Cdd:cd18058 79 YHGSQISRQmiqqyemyyRDEQGNPLSGIfkFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKLMA 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831511703 561 ARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTgmmegnmefnAPLIGRLHKVLRPFILRR 634
Cdd:cd18058 159 LEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLKT----------EEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
412-634 |
2.13e-38 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 144.44 E-value: 2.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILT 491
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKERA----------------EKRKGWMKPNC---FHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQR 552
Cdd:cd18056 81 YVGDKDSRAiirenefsfednairgGKKASRMKKEAsvkFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 553 WQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLtgmmegnmefNAPLIGRLHKVLRPFIL 632
Cdd:cd18056 161 FRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIA----------KEDQIKKLHDMLGPHML 230
|
..
gi 1831511703 633 RR 634
Cdd:cd18056 231 RR 232
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
412-634 |
4.87e-38 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 143.28 E-value: 4.87e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEMEFKKWCPALKILT 491
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKERAEKRKG----------------WMKPNC---FHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQR 552
Cdd:cd18057 81 YTGDKESRSVIRENefsfednairsgkkvfRMKKEAqikFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 553 WQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPltgmmegnmeFNAPLIGRLHKVLRPFIL 632
Cdd:cd18057 161 FRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADI----------SKEDQIKKLHDLLGPHML 230
|
..
gi 1831511703 633 RR 634
Cdd:cd18057 231 RR 232
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
434-604 |
8.78e-38 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 142.82 E-value: 8.78e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 434 ILADEMGLGKTIQTISLL-AHMACSESIWGPhLIVVPTSVILNWEMEFKKWCPA----LKILTYF---GTAKERAEKRKG 505
Cdd:cd18007 30 ILAHTMGLGKTLQVITFLhTYLAAAPRRSRP-LVLCPASTLYNWEDEFKKWLPPdlrpLLVLVSLsasKRADARLRKINK 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 506 WMKpncfH--VCITSY-------KTVTQDIRAF-KQRAWQ------YLILDEAQNIKNWKSQRWQALLNVRARRRLLLTG 569
Cdd:cd18007 109 WHK----EggVLLIGYelfrnlaSNATTDPRLKqEFIAALldpgpdLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTG 184
|
170 180 190
....*....|....*....|....*....|....*
gi 1831511703 570 TPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNP 604
Cdd:cd18007 185 TPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKP 219
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
412-634 |
2.26e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 138.24 E-value: 2.26e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACsESIWGPHLIVVPTSVILNWEMEFKKWCpALKILT 491
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYL-KGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKERAEKR--------------KGWMKpncFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALL 557
Cdd:cd18059 79 YHGSQASRRTIQlyemyfkdpqgrviKGSYK---FHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLK 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831511703 558 NVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTgmmegnmefnAPLIGRLHKVLRPFILRR 634
Cdd:cd18059 156 MMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
434-597 |
9.44e-34 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 130.40 E-value: 9.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 434 ILADEMGLGKTIQTISLlahMACSESIWgPHLIVVPTSVILNWEMEFKKWCPALKILTYFGTAKERAEKRKGWMKpncfh 513
Cdd:cd18010 20 LIADEMGLGKTVQAIAI---AAYYREEW-PLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKSKDGLRDGDAK----- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 514 VCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNV--RARRRLLLTGTPLQNSLMELWSLMHFLMPTIF 591
Cdd:cd18010 91 VVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVILLSGTPALSRPIELFTQLDALDPKLF 170
|
....*.
gi 1831511703 592 SSHDDF 597
Cdd:cd18010 171 GRFHDF 176
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
412-634 |
1.53e-33 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 130.13 E-value: 1.53e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSeSIWGPHLIVVPTSVILNWEMEFKKWCpALKILT 491
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLT-GIRGPFLIIAPLSTIANWEREFRTWT-DLNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 492 YFGTAKERAEKRKGWM-----------KPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQALLNVR 560
Cdd:cd18061 79 YHGSLISRQMIQQYEMyfrdsqgriirGAYRFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMN 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831511703 561 ARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLTgmmegnmefnAPLIGRLHKVLRPFILRR 634
Cdd:cd18061 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
428-634 |
8.58e-31 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 122.58 E-value: 8.58e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 428 EKNLNGILADEMGLGKTIQTISLLAHmacsesiwGPHLIVVPTSVILNWEMEFKKWCP--ALKILTYFGTAKERAEKRKG 505
Cdd:cd18071 46 ELVRGGILADDMGLGKTLTTISLILA--------NFTLIVCPLSVLSNWETQFEEHVKpgQLKVYTYHGGERNRDPKLLS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 506 wmkpnCFHVCITSYKTVTQDIRA-----FKQRAWQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELW 580
Cdd:cd18071 118 -----KYDIVLTTYNTLASDFGAkgdspLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLG 192
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1831511703 581 SLMHFLMPTIFSSHDDFKDWFSNPLTGMMEGNMEfnapligRLHKVLRPFILRR 634
Cdd:cd18071 193 SLLSFLHLKPFSNPEYWRRLIQRPLTMGDPTGLK-------RLQVLMKQITLRR 239
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
411-600 |
2.06e-29 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 117.59 E-value: 2.06e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 411 QLREYQMVGLDWMvtlYEKNLNGILADEMGLGKTIQtISLLAHMACSESIWGPHLIVVPT-SVILNWEMEFKKWCP--AL 487
Cdd:smart00487 8 PLRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLA-ALLPALEALKRGKGGRVLVLVPTrELAEQWAEELKKLGPslGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 488 KILTYFGTAKERAEKRKgwMKPNCFHVCITSYKTVTQDIR--AFKQRAWQYLILDEAQNIKNWK-SQRWQALLNV--RAR 562
Cdd:smart00487 84 KVVGLYGGDSKREQLRK--LESGKTDILVTTPGRLLDLLEndKLSLSNVDLVILDEAHRLLDGGfGDQLEKLLKLlpKNV 161
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1831511703 563 RRLLLTGTPLQNSLMELWSLMH--FLMPTIFSSHDDFKDW 600
Cdd:smart00487 162 QLLLLSATPPEEIENLLELFLNdpVFIDVGFTPLEPIEQF 201
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
412-605 |
3.35e-28 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 114.94 E-value: 3.35e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLdwmVTLYE----KNLNG----ILADEMGLGKTIQTISLLAHMACSesiwGPH---------LIVVPTSVIL 474
Cdd:cd18066 1 LRPHQREGI---EFLYEcvmgMRVNErfgaILADEMGLGKTLQCISLIWTLLRQ----GPYggkpvikraLIVTPGSLVK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 475 NWEMEFKKWCPALKILTYFGTAKERAEKrkgWMKPNCFHVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQRWQ 554
Cdd:cd18066 74 NWKKEFQKWLGSERIKVFTVDQDHKVEE---FIASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTT 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1831511703 555 ALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPL 605
Cdd:cd18066 151 ALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPI 201
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
412-634 |
1.33e-27 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 113.73 E-value: 1.33e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMvtLYEKNLN---GILADEMGLGKTIQTISLLahMACSE-------------SIWGPH----------- 464
Cdd:cd18072 1 LLLHQKQALAWL--LWRERQKprgGILADDMGLGKTLTMIALI--LAQKNtqnrkeeekekalTEWESKkdstlvpsagt 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 465 LIVVPTSVILNWEMEFKKWCP--ALKILTYFGTAKERAEKRKgwmkpNCFHVCITSYKTVTQDIRAFKQR---------A 533
Cdd:cd18072 77 LVVCPASLVHQWKNEVESRVAsnKLRVCLYHGPNRERIGEVL-----RDYDIVITTYSLVAKEIPTYKEEsrssplfriA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 534 WQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFsshDDFKDWFSNPLTGMMEGNm 613
Cdd:cd18072 152 WARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPF---DDLKVWKKQVDNKSRKGG- 227
|
250 260
....*....|....*....|.
gi 1831511703 614 efnapliGRLHKVLRPFILRR 634
Cdd:cd18072 228 -------ERLNILTKSLLLRR 241
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
412-605 |
2.81e-27 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 112.56 E-value: 2.81e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWM---VT-LYEKNLNG-ILADEMGLGKTIQTISLLAHMACSESIWGPHL----IVVPTSVILNWEMEFKK 482
Cdd:cd18067 1 LRPHQREGVKFLyrcVTgRRIRGSHGcIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaiVVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 483 WC-PALKILTYFG-TAKERAEKRKGWM--------KPncfhVCITSYKTVTQDIRAFKQRAWQYLILDEAQNIKNWKSQR 552
Cdd:cd18067 81 WLgGRLQPLAIDGgSKKEIDRKLVQWAsqqgrrvsTP----VLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQT 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1831511703 553 WQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPL 605
Cdd:cd18067 157 YQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPI 209
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
1042-1155 |
4.54e-27 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 107.30 E-value: 4.54e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1042 GKLQTLAVLLRQLYlyKHRCLIFTQMSKMLDvLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNADPkvFCFILSTRSGG 1121
Cdd:pfam00271 1 EKLEALLELLKKER--GGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGK--IDVLVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 1831511703 1122 VGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIG 1155
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
433-606 |
6.46e-26 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 108.82 E-value: 6.46e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 433 GILADEMGLGKTIQTISLLAHMACSESIWGPH--LIVVPTSVILNWEMEFKKWCPALKI--------LTYFGTAKERAEK 502
Cdd:cd18068 31 CILAHCMGLGKTLQVVTFLHTVLLCEKLENFSrvLVVCPLNTVLNWLNEFEKWQEGLKDeekievneLATYKRPQERSYK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 503 RKGWMKPNcfHVCITSYK-----TVTQDIRA---FKQRAWQYL--------ILDEAQNIKNWKSQRWQALLNVRARRRLL 566
Cdd:cd18068 111 LQRWQEEG--GVMIIGYDmyrilAQERNVKSrekLKEIFNKALvdpgpdfvVCDEGHILKNEASAVSKAMNSIRTKRRIV 188
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1831511703 567 LTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPLT 606
Cdd:cd18068 189 LTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQ 228
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
434-605 |
8.49e-25 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 104.90 E-value: 8.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 434 ILADEMGLGKTIQTIS----LLAHMACSESiwgphLIVVPTSVILNWEMEFKKWCPAlkiltyfgtakeraEKRKGWMKP 509
Cdd:cd18069 32 ILAHSMGLGKTLQVISfldvLLRHTGAKTV-----LAIVPVNTLQNWLSEFNKWLPP--------------PEALPNVRP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 510 NCFHVCITSYKTVTQDIRAFKQRAWQY--------------------LILDEAQNIKNWKSQRWQALLNVRARRRLLLTG 569
Cdd:cd18069 93 RPFKVFILNDEHKTTAARAKVIEDWVKdggvllmgyemfrlrpgpdvVICDEGHRIKNCHASTSQALKNIRSRRRIVLTG 172
|
170 180 190
....*....|....*....|....*....|....*.
gi 1831511703 570 TPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSNPL 605
Cdd:cd18069 173 YPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPI 208
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
434-597 |
2.94e-24 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 102.75 E-value: 2.94e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 434 ILADEMGLGKTIQTIsLLAHMACSESIWGPHLIVVPTSVILNW--EMEFKKWCPALkILTYFGTAKERAEKRKGWmkpNC 511
Cdd:cd18011 21 LLADEVGLGKTIEAG-LIIKELLLRGDAKRVLILCPASLVEQWqdELQDKFGLPFL-ILDRETAAQLRRLIGNPF---EE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 512 FHVCITSYKTVTQDI---RAFKQRAWQYLILDEAQNIKNW----KSQRWQA--LLNVRARRRLLLTGTPLQNSLMELWSL 582
Cdd:cd18011 96 FPIVIVSLDLLKRSEerrGLLLSEEWDLVVVDEAHKLRNSgggkETKRYKLgrLLAKRARHVLLLTATPHNGKEEDFRAL 175
|
170
....*....|....*
gi 1831511703 583 MHFLMPTIFSSHDDF 597
Cdd:cd18011 176 LSLLDPGRFAVLGRF 190
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1072-1155 |
5.47e-22 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 91.89 E-value: 5.47e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1072 DVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNADPKVFcfILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRC 1151
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKV--LVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 1831511703 1152 HRIG 1155
Cdd:smart00490 79 GRAG 82
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
412-598 |
9.36e-20 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 91.25 E-value: 9.36e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVtlyekNLNGILADEMGLGKTIQTISLLAH-----------------MACSESIW--------GPHLI 466
Cdd:cd18070 1 LLPYQRRAVNWML-----VPGGILADEMGLGKTVEVLALILLhprpdndldaadddsdeMVCCPDCLvaetpvssKATLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 467 VVPTSVILNWEMEFKKWCP-ALKILTYFGtakerAEKRKGWMKPNCFHVC-----ITSYKTVTQDI------------RA 528
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPsSLKVLTYQG-----VKKDGALASPAPEILAeydivVTTYDVLRTELhyaeanrsnrrrRR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 529 FKQRA----------WQYLILDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFK 598
Cdd:cd18070 151 QKRYEappsplvlveWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFCDSDWWA 230
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
412-586 |
5.93e-19 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 87.79 E-value: 5.93e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVtlyEKNLNGILADeMGLGKTIQTISLLAHMAcSESIWGPHLIVVPTSVILN-WEMEFKKWcPALKIL 490
Cdd:cd18013 1 PHPYQKVAINFII---EHPYCGLFLD-MGLGKTVTTLTALSDLQ-LDDFTRRVLVIAPLRVARStWPDEVEKW-NHLRNL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 491 TYF---GTAKERaekRKGWMKPNcfHVCITSYKTVTQDIRAFKQRaWQY--LILDEAQNIKNWKSQRWQALLNVR--ARR 563
Cdd:cd18013 75 TVSvavGTERQR---SKAANTPA--DLYVINRENLKWLVNKSGDP-WPFdmVVIDELSSFKSPRSKRFKALRKVRpvIKR 148
|
170 180
....*....|....*....|...
gi 1831511703 564 RLLLTGTPLQNSLMELWSLMHFL 586
Cdd:cd18013 149 LIGLTGTPSPNGLMDLWAQIALL 171
|
|
| HSA |
pfam07529 |
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. ... |
85-149 |
8.34e-17 |
|
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. This region does not form a compact domain in the known structures.
Pssm-ID: 462194 [Multi-domain] Cd Length: 67 Bit Score: 76.46 E-value: 8.34e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831511703 85 VEPER-NKTHWDYLLEEVKWMAVDFRTETNTKRKIAKVIAHAIAKQHRDKQIEIERAAEREIKEKR 149
Cdd:pfam07529 2 DEPERrEKTHHDYLLEEILWHSKDFKQERRWKRARAKKLARAVAQYHKNIEKEEQKRIEREEKQRL 67
|
|
| HSA |
smart00573 |
domain in helicases and associated with SANT domains; |
82-151 |
6.23e-14 |
|
domain in helicases and associated with SANT domains;
Pssm-ID: 214727 [Multi-domain] Cd Length: 73 Bit Score: 68.58 E-value: 6.23e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 82 PKCVEPERNKTHWDYLLEEVKWMAVDFRTETNTKRKIAKVIAHAIAKQHRDKQIEIERAAEREikEKRKM 151
Cdd:smart00573 1 QKLEEERRRKQHWDHLLEEMIWHAKDFKEEHKWKIAAAKKMAKAVMDYHQNKEKEEERREEKN--EKRRL 68
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
410-571 |
4.83e-11 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 68.13 E-value: 4.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 410 GQLREYQMVGLD-WMVTLYEKNLNGILADEMGLGKTIqtisLLAHMACSESIWGPHLIVVPTSVILN-WEMEFKKWCPAl 487
Cdd:COG1061 79 FELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKTV----LALALAAELLRGKRVLVLVPRRELLEqWAEELRRFLGD- 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 488 kiltyfgtakeraEKRKGWMKPNCFHVCITSYKTVTQDIRAFK-QRAWQYLILDEAQNIKnwkSQRWQALLN-VRARRRL 565
Cdd:COG1061 154 -------------PLAGGGKKDSDAPITVATYQSLARRAHLDElGDRFGLVIIDEAHHAG---APSYRRILEaFPAAYRL 217
|
....*.
gi 1831511703 566 LLTGTP 571
Cdd:COG1061 218 GLTATP 223
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
412-571 |
8.23e-08 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 53.46 E-value: 8.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 412 LREYQMVGLDWMVtLYEKNLNGILADEMGLGKTIqtISLLAHMACSEsiwGPHLIVVPTSVILN-WEMEFKKWCPALKIL 490
Cdd:cd17926 1 LRPYQEEALEAWL-AHKNNRRGILVLPTGSGKTL--TALALIAYLKE---LRTLIVVPTDALLDqWKERFEDFLGDSSIG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 491 TYFGTAKEraekrkgwmKPNCFHVCITSYKTVTQDIRA--FKQRAWQYLILDEAQNI--KNWKsqrwQALLNVRARRRLL 566
Cdd:cd17926 75 LIGGGKKK---------DFDDANVVVATYQSLSNLAEEekDLFDQFGLLIVDEAHHLpaKTFS----EILKELNAKYRLG 141
|
....*
gi 1831511703 567 LTGTP 571
Cdd:cd17926 142 LTATP 146
|
|
| DISARM_DrmD_b |
NF038318 |
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component ... |
1094-1169 |
2.06e-06 |
|
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component of class 1 DISARM (Defence Island System Associated with Restriction Modification), which contains a DNA adenine N6 methyltransferase. This HMM describes a distinct form that is somewhat shorter than the majority of DrmD proteins.
Pssm-ID: 468472 [Multi-domain] Cd Length: 868 Bit Score: 53.15 E-value: 2.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1094 VEQRQAMMERFNADPKVfcfILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQ-----------TRNVS- 1161
Cdd:NF038318 473 VEYKHAIVDYFKNNAKI---LIVTDAGSEGLNLQFCNTVINYDLPWNPQKIEQRIGRCHRYGQkndvvainllnTQNVAd 549
|
90
....*....|
gi 1831511703 1162 --IYRLISER 1169
Cdd:NF038318 550 krVYEILSEK 559
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
432-570 |
4.03e-05 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 45.86 E-value: 4.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 432 NGILADEMGLGKTIQ-TISLLAHMACSEsiwGPHLIVVPTSVILN-WEMEFKKWCPALKILTYFGTAKERAEKRKGWMKP 509
Cdd:cd00046 3 NVLITAPTGSGKTLAaLLAALLLLLKKG---KKVLVLVPTKALALqTAERLRELFGPGIRVAVLVGGSSAEEREKNKLGD 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831511703 510 NcfHVCITSYKTVTQDIRA---FKQRAWQYLILDEAQNIKNWKSQRWQALLNVRAR-----RRLLLTGT 570
Cdd:cd00046 80 A--DIIIATPDMLLNLLLRedrLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAglknaQVILLSAT 146
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
1039-1157 |
3.22e-04 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 42.88 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1039 YDCGKLQTLAVLLRQLY--LYKHRCLIFTQMSKMLDVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNAdpKVFCFILS 1116
Cdd:cd18787 6 VVVEEEEKKLLLLLLLLekLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRS--GKVRVLVA 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1831511703 1117 T----RsggvGVNLTGADTVIFYDsdwnptMDAQAQDRCHRIGQT 1157
Cdd:cd18787 84 TdvaaR----GLDIPGVDHVINYD------LPRDAEDYVHRIGRT 118
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
53-329 |
6.08e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 45.52 E-value: 6.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 53 VERAAKREAHVLARIAELRKNGLWSNSRLPKCVEPERNKTHWDYLLEEVKWMAVDFRTETNTKRKIAKViahaiaKQHRD 132
Cdd:PTZ00121 1557 LKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEEL------KKAEE 1630
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 133 KQIEIERAAEREIKEKRKmcagiAKMVRdfwsstdkvvdiraKEVLESRLRKARNKHlmfvigqvdemsnivqeglvsss 212
Cdd:PTZ00121 1631 EKKKVEQLKKKEAEEKKK-----AEELK--------------KAEEENKIKAAEEAK----------------------- 1668
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 213 kspsIASDRDDKDEEFKAPGSDSESDDEQTIANAEKSQKKEDVRQEVDALQNEATvdmddflytlppEYLKAYGLTQEDL 292
Cdd:PTZ00121 1669 ----KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAE------------ELKKAEEENKIKA 1732
|
250 260 270
....*....|....*....|....*....|....*..
gi 1831511703 293 EEMKREKLEEQKARKEACGDNEEKMEIDESPSSDAQK 329
Cdd:PTZ00121 1733 EEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKK 1769
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
1113-1157 |
1.98e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 38.84 E-value: 1.98e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1831511703 1113 FILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQT 1157
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKD 69
|
|
| DEXHc_XPB |
cd18029 |
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ... |
411-570 |
2.67e-03 |
|
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350787 [Multi-domain] Cd Length: 169 Bit Score: 40.75 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 411 QLREYQmvgldwmvtlyEKNLN----------GILADEMGLGKTIQTISLLAHMACSEsiwgphLIVVPTSV-ILNWEME 479
Cdd:cd18029 8 QLRPYQ-----------EKALSkmfgngrarsGVIVLPCGAGKTLVGITAACTIKKST------LVLCTSAVsVEQWRRQ 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 480 FKKWC--PALKILTYFGTAKERAEKRKgwmkpncfhVCITSYKTVTQDIRAFKQ----------RAWQYLILDEAQNIKN 547
Cdd:cd18029 71 FLDWTtiDDEQIGRFTSDKKEIFPEAG---------VTVSTYSMLANTRKRSPEsekfmefiteREWGLIILDEVHVVPA 141
|
170 180
....*....|....*....|...
gi 1831511703 548 WKSQRWQALlnVRARRRLLLTGT 570
Cdd:cd18029 142 PMFRRVLTL--QKAHCKLGLTAT 162
|
|
| MDN1 |
COG5271 |
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ... |
222-379 |
3.93e-03 |
|
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444083 [Multi-domain] Cd Length: 1028 Bit Score: 42.69 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 222 DDKDEEFKAPGSDSESDDEQTIANAEKSQKKEDVRQEVDALQNEATVDMDDFLYTLPPEYLKAYGLTQEDLEEMKRE-KL 300
Cdd:COG5271 538 DETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAETEDATENADADETEESADESEEAEASEDEAAEEEEADDDEaDA 617
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831511703 301 EEQKARKEACGDNEEKMEIDESPSSDAQKPSTSSSDLTAEqlqDPTAEDGNGDghgvlENVDYVKLNSQDSDERQQELA 379
Cdd:COG5271 618 DADGAADEEETEEEAAEDEAAEPETDASEAADEDADAETE---AEASADESEE-----EAEDESETSSEDAEEDADAAA 688
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
1832-2213 |
5.71e-03 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 41.92 E-value: 5.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1832 IQHLQSSSTGLGSQQNLQNSHNSEQRNNVQNMHQNQYNSSQN--------------PPIPIRQIGA-------ASSHQHD 1890
Cdd:pfam09606 47 ILHVRDMSKKAAQQQQPQGGQGNGGMGGGQQGMPDPINALQNlagqgtrpqmmgpmGPGPGGPMGQqmggpgtASNLLAS 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1891 QGS----QGPGGKPQAYHLVQQGSQ------QQQQQQQQATLQRRNAAAAAGSNVQFIQQQQQQQQSGKNCGQ--GQSFV 1958
Cdd:pfam09606 127 LGRpqmpMGGAGFPSQMSRVGRMQPggqaggMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQmpPQMGV 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 1959 VMGSQSSSNDGQGGASTVGGGGGGSQQPHQQQQQQPQQRIQYIPQVTGSGNNGGGGGRGGygstlvMPRGGRVVRPAGtL 2038
Cdd:pfam09606 207 PGMPGPADAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQSQLGMGINQMQQ------MPQGVGGGAGQG-G 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 2039 PGGGRLYVDHNRHPYP--MSSNVVPVRVLPATQQGQQRMmtGQRRPAPAPGTVAAMVLPNRGAGGIPQMRSLQRGSYTGG 2116
Cdd:pfam09606 280 PGQPMGPPGQQPGAMPnvMSIGDQNNYQQQQTRQQQQQQ--GGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNF 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511703 2117 GGQQrINVMVQpqqmrsnngggvggqgglqggpggpqgirrplvGRPLQRGVDNQAPTVAQVVVAPPQGMQQASQgppvl 2196
Cdd:pfam09606 358 GGLG-ANPMQR---------------------------------GQPGMMSSPSPVPGQQVRQVTPNQFMRQSPQ----- 398
|
410
....*....|....*..
gi 1831511703 2197 hmQRAVSMQMPTSHHHQ 2213
Cdd:pfam09606 399 --PSVPSPQGPGSQPPQ 413
|
|
| |
