|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
42-477 |
0e+00 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 727.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 42 LAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYII 121
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHSSSPSVEHNETGKKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 122 TQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSI 201
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 202 SYA-AQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVsdtpqkhkrishyekeyilsslrnqlssqksvp 280
Cdd:cd17381 161 SYAgAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV--------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 281 wvpilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTL 360
Cdd:cd17381 208 -------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFSTV 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 361 CVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGP 440
Cdd:cd17381 281 CVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVGP 360
|
410 420 430
....*....|....*....|....*....|....*..
gi 1843419856 441 VIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFA 477
Cdd:cd17381 361 VIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
43-477 |
0e+00 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 540.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 43 AILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKAcpehsapiKVHHNQTGKKYQWDAETQGWILGSFFYGYIIT 122
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTD--------KDTLPVEAPEFDWSEKTQGIILSSFFYGYILT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 123 QIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSIS 202
Cdd:cd17318 73 QIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 203 YA-AQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVsdtpqkhkrishyekeyilsslrnqlssqksvpw 281
Cdd:cd17318 153 YSgSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV---------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 282 vpilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLC 361
Cdd:cd17318 199 ------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTT 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 362 VRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPV 441
Cdd:cd17318 273 VRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPL 352
|
410 420 430
....*....|....*....|....*....|....*..
gi 1843419856 442 IAKSLTPDN-TVGEWQTVFYIAAAINVFGAIFFTLFA 477
Cdd:cd17318 353 IVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
43-477 |
9.38e-125 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 368.98 E-value: 9.38e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 43 AILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTskacpehsapikvhhNQTGKKYQWDAETQGWILGSFFYGYIIT 122
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKV---------------IVHKAEFNWTPETVGLIESSFFWGYLVT 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 123 QIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSIS 202
Cdd:cd17382 66 QIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 203 YA-AQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLvsdtpqkhkrishyekeyilsslrnqlssqksvpw 281
Cdd:cd17382 146 FCgSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV----------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 282 vpilkSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLC 361
Cdd:cd17382 191 -----SMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 362 VRRIFSLIGMIGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPV 441
Cdd:cd17382 266 VRKIFNCGGFGMEATFLLVVAFSH-SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPV 344
|
410 420 430
....*....|....*....|....*....|....*.
gi 1843419856 442 IAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFA 477
Cdd:cd17382 345 IVGALTKHKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
30-490 |
1.42e-119 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 358.67 E-value: 1.42e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 30 EAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSnttleDNRTSKACPEHSAPIKVHHNqtgKKYQWDAETQG 109
Cdd:TIGR00894 8 TKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNK-----ENSTDLACLSAENELDNIKN---PNFKWSGALQG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 110 WILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:TIGR00894 80 LILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 190 APPLERSKLLSISYA-AQLGTVISLPLSGIIC-YYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILS 267
Cdd:TIGR00894 160 APPKERSRLLGMSTSgFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 268 SLRNQ-LSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQ 346
Cdd:TIGR00894 240 SLQGQkGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 347 AADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLG 426
Cdd:TIGR00894 320 LADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKG 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843419856 427 ITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALNDHH 490
Cdd:TIGR00894 400 ITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKD 463
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
44-477 |
3.64e-112 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 336.06 E-value: 3.64e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 44 ILAFFGFFIVYALRVNLSVALVDMVdsnttlednrtskacpehsapikvhhnqtgKKYQWDAETQGWILGSFFYGYIITQ 123
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMA------------------------------KEFGWSKTDQGLVLSSFFWGYALTQ 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 124 IPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISY 203
Cdd:cd17380 52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVT 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 204 AA-QLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSdtpqkhkrishyekeyilsslrnqlssqksvpwv 282
Cdd:cd17380 132 AGsYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP---------------------------------- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 283 pilkslPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILrFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKwNFSTLCV 362
Cdd:cd17380 178 ------PVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISR-GWTVTSV 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 363 RRIFSLIGMIGPAVFLVAAGFIgCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVI 442
Cdd:cd17380 250 RKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYL 328
|
410 420 430
....*....|....*....|....*....|....*
gi 1843419856 443 AKSLTpdNTVGEWQTVFYIAAAINVFGAIFFTLFA 477
Cdd:cd17380 329 TGYIL--EATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
39-471 |
1.53e-50 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 176.22 E-value: 1.53e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 39 RYNLAILAFFGFFIVYALRVNLSVALVDMvdsnttlednrtskacpehsapikvhhnqtGKKYQWDAETQGWILGSFFYG 118
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTI------------------------------MKDLGLSPTQYGLIASAFFLG 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 119 YIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAAdlGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:cd17319 51 YALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 199 LSISYAAQ-LGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVsdtPQkhkrishyekeyilsslrnqlssqk 277
Cdd:cd17319 129 TGLFNSGApLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL---RQ------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 278 svpwvpilkslpLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKwnf 357
Cdd:cd17319 181 ------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG--- 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 358 stlcVRRIFSLIGMIGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFCSSGFSINHLDIAP-SYAGILLGITNTFATIPG 436
Cdd:cd17319 246 ----ARRLVIIIGLLLAAVGLLLAYLTT-SPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATAGGLINSGGNLGG 320
|
410 420 430
....*....|....*....|....*....|....*
gi 1843419856 437 MVGPVIAKSLTpdNTVGEWQTVFYIAAAINVFGAI 471
Cdd:cd17319 321 FVAPLLIGYLV--DATGSYTAAFLFLAAVALLAAL 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-478 |
2.55e-44 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 159.65 E-value: 2.55e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 39 RYNLAILAFFGFFIVYALRVNLSVALVDMVDSnttlednrtskacpehsapikvhhnqtgkkYQWDAETQGWILGSFFYG 118
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQAD------------------------------LGLSAAQLGLLASAFFLG 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 119 YIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:COG2271 58 YALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQ--LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 199 LSISYAAQ-LGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLvsdtpqkhkrishyekeyilsslrnqlssqk 277
Cdd:COG2271 136 LGIFNAGGpLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWL------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 278 svpwvpilkslplwaIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKwnf 357
Cdd:COG2271 185 ---------------LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR--- 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 358 stlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGM 437
Cdd:COG2271 247 -----RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1843419856 438 VGPVIAKSLTpdnTVGEWQTVFYIAAAINVFGAIFFTLFAK 478
Cdd:COG2271 322 LGPLLVGYLL---DATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
101-473 |
9.81e-44 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 158.36 E-value: 9.81e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 101 YQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFP 180
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWL--LLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 181 AMHAMWSSWAPPLERSKLLSISYAAQ-LGTVISLPLSGIICYY--MNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRI 257
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGsVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 258 SHYEKeyilsslrnqlSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGS 337
Cdd:cd06174 184 NEEAS-----------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 338 WLCMILSGQAADNLRAkwnfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIA 417
Cdd:cd06174 253 ALGSLLLGLLSDRLIG---------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1843419856 418 PSYAGILLGITNTFATIPGMVGPVIAKSLTpdNTVGEWQTVFYIAAAINVFGAIFF 473
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLL--AATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
98-440 |
1.79e-34 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 132.16 E-value: 1.79e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 98 GKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGV 177
Cdd:pfam07690 24 AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL--LLVLRVLQGLGAGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 178 TFPAMHAMWSSWAPPLERSKLLSISYAA-QLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKR 256
Cdd:pfam07690 102 LFPAALALIADWFPPEERGRALGLVSAGfGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 257 ishyekeyilssLRNQLSSQKSVPWVPILKSLPLWAIVVAhFSYNWTFYTLLTLLPTYMkEILRFNVQENGFLSSLPYLG 336
Cdd:pfam07690 182 ------------PAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 337 SWLCMILSGQAADNLRAKwnfstlcVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDI 416
Cdd:pfam07690 248 GAIGRLLLGRLSDRLGRR-------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 1843419856 417 APSYAGILLGITNTFATIPGMVGP 440
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
109-477 |
7.00e-31 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 123.07 E-value: 7.00e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--LLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 189 WAPPLERSKLLSISYAAQ-LGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRishyekeyils 267
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIgLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 268 slRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQA 347
Cdd:cd17325 181 --RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 348 ADNLRakwnfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGI 427
Cdd:cd17325 259 SDRIG----------RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1843419856 428 TNTFATIPGMVGPVIAKSLTpdnTVGEWQTVFYIAAAINVFGAIFFTLFA 477
Cdd:cd17325 329 FNTAFSLGMVLGPLLGGFLY---DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
37-476 |
9.23e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 117.29 E-value: 9.23e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 37 SARYNLAILAFFGFFIVYALRVNLSVALVDMvdsnttlednrtskacpehsapikvhhnqtGKKYQWDAETQGWILGSFF 116
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPL------------------------------AEEFGLSAAQLGLLFAIPV 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 117 YGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERS 196
Cdd:COG2223 51 LVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWL--LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRG 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 197 KLLSISYAA-QLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHyekeyilSSLRNQLSs 275
Cdd:COG2223 129 LALGLAAGGgNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK-------ASLRDQLE- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 276 qksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRakw 355
Cdd:COG2223 201 --------ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIG--- 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 356 nfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLA-VAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATI 434
Cdd:COG2223 270 -------GRRVLLIVFALMALGLLLLALALGSLWLFlVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGL 342
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1843419856 435 PGMVGPVIAKSLTpdNTVGEWQTVFYIAAAINVFGAIFFTLF 476
Cdd:COG2223 343 GGFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
101-434 |
1.73e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 106.98 E-value: 1.73e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 101 YQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFP 180
Cdd:COG2814 40 LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL--LLAARFLQGLGAGALFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 181 AMHAMWSSWAPPLERSKLLSISYAAQ-LGTVISLPLSGIICYYMNWTYVFYFFGTIG-IFWFLLWIWLVSDTPQKHKRIS 258
Cdd:COG2814 118 AALALIADLVPPERRGRALGLLGAGLgLGPALGPLLGGLLADLFGWRWVFLVNAVLAlLALLLLLRLLPESRPAARARLR 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 259 HYEKEyilsslrnqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSW 338
Cdd:COG2814 198 GSLRE--------------------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 339 LCMILSGQAADNLRakwnfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAP 418
Cdd:COG2814 258 LGALLAGRLADRFG----------RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327
|
330
....*....|....*.
gi 1843419856 419 SYAGILLGITNTFATI 434
Cdd:COG2814 328 EARGRASGLYNSAFFL 343
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
109-442 |
1.82e-19 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 90.13 E-value: 1.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFtpIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 189 WAPPLERSKLLSI-SYAAQLGTVISLPLSGI-ICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRIS-----HYE 261
Cdd:TIGR00881 111 WFSRSERGTWVSFwNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPaeempNEE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 262 KEYILSSLRNQLSSQKSVPWVpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCM 341
Cdd:TIGR00881 191 PDGDAEKKEEELTKKQIFLQY-VLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGT 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 342 ILSGQAADNLrakwnfstlcVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGF----SINHLDIA 417
Cdd:TIGR00881 270 LLAGWLSDKL----------FNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPqmliGVIASELA 339
|
330 340
....*....|....*....|....*.
gi 1843419856 418 PSYA-GILLGITNTFATIPGMVGPVI 442
Cdd:TIGR00881 340 PKKAaGTAAGFVGFFAYLGGILAGLP 365
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
110-445 |
1.46e-18 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 87.69 E-value: 1.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 110 WILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTpiAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLT--AAVKNFGGLIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 190 APPLERSKLLSISYAAQLGTVIslpLSGII---CYYM-------NWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISH 259
Cdd:cd17327 123 YKREEQAKRIAFFYAAAGLGSI---FGGLLaygVFKIlgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 260 YEKEYILSSLR-NQ--LSSQKSVP--WVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENgFLSSLPY 334
Cdd:cd17327 200 EEKELAVERLRaNQtgKGDQKFKWkqIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTN-LLSVPIG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 335 LGSWLCMILSGQAADNLRAKWNFSTlcvrrIFSLIGMIGPAVfLVAAGFIGCDYsLAVAFLTISTTLGGFCSSGFSINhl 414
Cdd:cd17327 279 ALGAVSLLIAALLSDRFKKRGLFAI-----FACVLALVGSII-LLAAPNPPGAY-FAAYILGGGSYAGFPILLSWISS-- 349
|
330 340 350
....*....|....*....|....*....|...
gi 1843419856 415 dIAPSYAG--ILLGITNTFATIPGMVGPVIAKS 445
Cdd:cd17327 350 -NCAGYTKraTVLAIMLIFYNVGNIVAPQIFRA 381
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
109-474 |
2.80e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 74.12 E-value: 2.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--LLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 189 WAPPLERSKLLSISYAA-QLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILs 267
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGlTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLL- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 268 slrnqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQA 347
Cdd:cd17324 194 ----------------LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 348 ADNLRAkwnfstlcvRRIFSLIGMIgpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGI 427
Cdd:cd17324 258 ADRGGR---------RALLIALLLL--AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSL 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1843419856 428 TNTFATIPGMVGPVIAKSLTpdnTVGEWQTVFYIAAAINVFGAIFFT 474
Cdd:cd17324 327 YLAAYNLGGALGAALGGLVL---DHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
109-476 |
3.72e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 73.76 E-value: 3.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGGK--MLLGFGILGTA-VLTLFTPiaadlGVGPLIVLRALEGLGEGVTFPAMHAM 185
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKkvLLPGLLLFGIGgLLCGLSD-----SFALLLAGRALQGIGAAGLGPLALTL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 186 WSSWAPPLERSKLLSIsYAAQLGTVISL-PLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEY 264
Cdd:cd17474 112 IGDLFEGGERAKAMGL-YEAALGLGIAVgPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRD 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 265 ILSSLRNQLssqksvpwvpilkslpLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSwlcMILS 344
Cdd:cd17474 191 LKKALRGRG----------------LLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL---ALGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 345 GQAADNLRAKWNFSTLCVrrifslIGMIGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYA-GI 423
Cdd:cd17474 252 LFVGRLLKKRFGARRILV------IGLLLYALSLLLLGFVP-SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGT 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1843419856 424 LLGITNTFATIPGMVGPVIAKSLTpdnTVGEWQTVFYIAAAINVFGAIFFTLF 476
Cdd:cd17474 325 ASSLYNFVRFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
104-446 |
2.23e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 71.62 E-value: 2.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADlgVGPLIVLRALEGLGEGVTFPAMH 183
Cdd:TIGR00895 50 DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATN--VTQLLILRFLAGLGLGGLMPNLN 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 184 AMWSSWAPPLERSKLLSISYAA-QLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWI--------WLVSDTPQKH 254
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCGyPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMrflpesidFLVSKRPETV 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 255 KRISHYEKEYILSSLRNQLSSQKSVP--WVPILK----------SLPLWaivVAHFSYNWTFYTLLTLLPTYMKEiLRFN 322
Cdd:TIGR00895 208 RRIVNAIAPQMQAEAQSALPEQKSTQgtKRSVFKalfqgktariTVLLW---LLYFMLLVGVYFLTNWLPKLMVE-LGFS 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 323 VQENGFLSSLPYLGSWLCMILSGQAADNLRAKwnfstlcvrriFSLIGMIGPAVFLVAAGFigcDYSLAVAFLTISTTLG 402
Cdd:TIGR00895 284 LSLAATGGALFNFGGVIGSIIFGWLADRLGPR-----------VTALLLLLGAVFAVLVGS---TLFSPTLLLLLGAIAG 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1843419856 403 GFCSSGFSINHLDIAPSYA--------GILLGITNTFAtipgMVGPVIAKSL 446
Cdd:TIGR00895 350 FFVNGGQSGLYALMALFYPtairatgvGWAIGIGRLGA----IIGPILAGYL 397
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
127-477 |
3.26e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 71.07 E-value: 3.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 127 GYVASKIGGKMLLGFGILGTAVLTLfTPIAADlGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAAQ 206
Cdd:cd17473 56 GWLADRFGRKRLLIAGLLLYGIGGV-AGLFLD-SLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAM 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 207 -LGTVISLPLSGIICYyMNWTYVFYFFGtIGIFWFLLWIWLVSDTPQKHKRISHYEKEyilsslrnqlsSQKSVPWVPIl 285
Cdd:cd17473 134 sLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLILVLLFLPEPARKSKSAASPGAA-----------TAAALPWKRV- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 286 kslplWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSwlcmILSGQAADNLRAKWNFSTLcVRRI 365
Cdd:cd17473 200 -----LPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAG----AIGALLFGRLKRRLGKRRL-LAIG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 366 FSL--IGMI------GPAVFLVAAGFIGCDYSLAVAFLTISTTlggfcssgfsinhLDIAPSYAGILLGITNTFATIPGM 437
Cdd:cd17473 270 FALmaLGFLllalasGLWVVLLGAILAGLGFGLLLPTLNSWAM-------------SLVPPELRGRAMGIVTSAFFLGQF 336
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1843419856 438 VGPVIAKSLTpdNTVGEWQTVFYIAAAINVFGAIFFTLFA 477
Cdd:cd17473 337 LSPLVLGPLV--NLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
109-442 |
7.57e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.80 E-value: 7.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMwSS 188
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPL--LLLALFLLGLGLGLLDVAANPY-VA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 189 WAPPLERSKLLSISYAAQ-LGTVISlPLSGIICYYMNWT-YVFYFFGTIGIFWFLLWIWLVsdtPQKHKRISHYEKEyil 266
Cdd:COG0738 123 ALGPETAASRLNLLHAFFsLGALLG-PLLGGLLILLGLSlSWHLPYLILAVLLLLLALLFL---RSKLPEIEEEEEE--- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 267 sslrnqlSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLpylgSWLCMILSGQ 346
Cdd:COG0738 196 -------AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL----FWGGMTIGRF 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 347 AADNLRAKWNFSTLCvrRIFSLIGMIGPAVFLVAAGFIgcdysLAVAFLTIsttLGGFCSSGFS-INHL--DIAPSYAGI 423
Cdd:COG0738 265 LGGFLLKRFGPVRLL--RLSALLAAVGLLLALLAPGPW-----LALIGLAL---VGLGLSLMFPtIFSLalDGLGKRTAA 334
|
330
....*....|....*....
gi 1843419856 424 LLGITNTFATIPGMVGPVI 442
Cdd:COG0738 335 AVSAVLIMGIVGGAIGPPL 353
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
104-246 |
2.65e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 64.45 E-value: 2.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMH 183
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPEL--LIAARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843419856 184 AMWSSWAPPLERSKLLSISYAAQ-LGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWL 246
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIgLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
109-473 |
3.51e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 64.57 E-value: 3.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPV--LLVLLFLVGAGYGSVQPGGGRAIMR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 189 WAPPLERSKLLSISYAAQ-LGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLL-WIWLV-SDTPQKHKRISHYEKEYI 265
Cdd:cd17475 112 WFPPRERGLAMGIRQTGVpLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLfWLFYRePPAASAATESASTLLRSL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 266 LSSLRNqlssqksvpwvpilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSG 345
Cdd:cd17475 192 KEVLRN----------------RDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 346 QAADNLRAKwnfstlcvRRIFSLIGMIGPAVfLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGF-SINHLDIA----PSY 420
Cdd:cd17475 256 RVSDRVFGG--------RRRPVLVITAAIAA-AALLVLSLLSPGTPLWLLVLLLILLGLFAIGWnGLYLTLVAesagPEQ 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1843419856 421 AGILLGITNTFATIPGMVGPVIAKSLTpdNTVGEWQTVFYIAAAINVFGAIFF 473
Cdd:cd17475 327 AGTALGLANTINFIGIAIGPPLFGLLV--DATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
106-473 |
8.61e-11 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 63.48 E-value: 8.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 106 ETQGWILGSFF-YGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHA 184
Cdd:cd17371 33 EAEAGLLGTVTlAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--LLILRALAGLGFGGEWAAGAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 185 MWSSWAPPLERSKLLSISYAAQ-----LGTVISLPLSGIICYYMNWTYVFYFfgtiGIFWFLLWIWL---VSDTPQkhkr 256
Cdd:cd17371 111 LMAEYVPARHRGKALGYVQSGWavgwlLATLLAALLFPLLPPEIAWRVLFLL----GALPALLVLFIrrfVKEPPQ---- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 257 ishyekeYILSSLRNQLSSQKSVPWV---PILKSLPLWAIVVAHFSYnWTFYTLLTLLPTYMKEILRFNVQENGFLSSLP 333
Cdd:cd17371 183 -------WQAARAARRHFADRPSLRElfsPPLLRTTLLASLLATGAL-GGYYGITTWLPSYLTGERGLSFEGSAGYLVVT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 334 YLGSWLCMILSGQAADNLRAKWNFstlcvrrifsLIGMIGPAVFLVAAGFIGCDYSLavafLTISTTLGGFCSSG-FSIN 412
Cdd:cd17371 255 ILGGFLGYLAGGFLADRIGRRNNF----------ALFALGSAISILLYFFLPLSPTL----ILILGFPLGFFASGpFSGM 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1843419856 413 HLDIAPSYA----GILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFF 473
Cdd:cd17371 321 GAYLTELFPtavrATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
39-476 |
1.83e-10 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 62.29 E-value: 1.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 39 RYNLAILAFFGFFIVYALRVNLSVALVDMVDsnttlednrtskacpehsapikvhhnqtgkKYQWDAETQGWILGSFFYG 118
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVE------------------------------EIGLSKDDLGIIGSAFLIA 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 119 YIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 198
Cdd:cd17312 51 YAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWF--FAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTV 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 199 LSI-SYAAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGI-FWFLLWIWLVSDtpqkhkrishyekeyilsslrnqlssq 276
Cdd:cd17312 129 YGIwSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLvVAIILFFFLRDS--------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 277 ksvPWVpilkslpLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLrakWN 356
Cdd:cd17312 182 ---PPY-------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKL---FG 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 357 FSTLCVRRIFSLIGMIGPAVFLVAAGFIgcdYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYA-GILLGITNTFATIP 435
Cdd:cd17312 249 GRRAPIAVIYMLLMTLSLALFWFFPHNK---LLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAaGTATGFVGLFGYLG 325
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1843419856 436 GMVGPVIAKSLTPDNTvgeWQTVFYIAAAINVFGAIFFTLF 476
Cdd:cd17312 326 ASLAGLPLGYIIDHYG---WSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
99-247 |
6.82e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 60.67 E-value: 6.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 99 KKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAAdlGVGPLIVLRALEGLGEGVT 178
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 179 FPAMHAMWSSWAPPLERSKLLSISYAAQ-LGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLV 247
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFsLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
124-482 |
1.38e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 59.89 E-value: 1.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 124 IPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAAdlGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPplERSKLLSISY 203
Cdd:COG2807 71 PLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP--SVALLLAGTALIGAGIAVGNVLLPGLIKRWFP--DRVGLMTGLY 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 204 AA--QLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRishyekeyilsslrnqlsSQKSVPW 281
Cdd:COG2807 147 TAamGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAA------------------APAAASL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 282 VPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEiLRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLC 361
Cdd:COG2807 209 RSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLL 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 362 vrrifSLIGMIGPAVFLVAAGfigcdySLAVAFLTIsttLGGFCSSGFS-----INHLDIAPSYAGILLGITNTFATIPG 436
Cdd:COG2807 288 -----GLLGLAGLLGLLLAPG------SLPWLWAVL---LGLGQGGLFPlaltlIGLRARTPAEAAALSGMAQSVGYLLA 353
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1843419856 437 MVGPVIA---KSLTpdntvGEWQTVFYIAAAINVFGAIFFTLFAKGEVQ 482
Cdd:COG2807 354 ALGPLLVgalHDAT-----GSWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
109-476 |
1.75e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.53 E-value: 1.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAAdlGVGPLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAATLVAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 189 WAPPLERSKLLSI-SYAAQLGTVISLPLSGIIcyYMNWTYVFYFFGTIGI-FWFLLWIWLVSDTPQKHKRIShyekeyil 266
Cdd:cd17489 112 IIPPSRRGEGIGYyGLATTLAMALGPALGLFL--YQHLGFAVLFIVAAVLaLLALLLVFLVKDPPPVAAEEA-------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 267 sslrnqlSSQKSVPWVPILKSLPLWAIVVAHFSYnwTFYTLLTLLPTYMKEILRFNVqenGFLSSLPYLGSWLCMILSGQ 346
Cdd:cd17489 182 -------EAGTRAFRRLVEKKVLPPALILFLASI--AYGAISTFLPLYAAERGISNA---GLFFTVYAIALLLSRPFSGK 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 347 AADNLRAK---WNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTtlggfcssgfsinhLDIAPSYA-G 422
Cdd:cd17489 250 LSDRKGPKtviIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALA--------------VDLVPPHRrG 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1843419856 423 ILLGITNTFATIPGMVGPVIAKSLTPdntVGEWQTVFYIAAAINVFGAIFFTLF 476
Cdd:cd17489 316 AANGTFFIFFDLGIGLGGLLLGLVAE---LFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
104-471 |
2.26e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.15 E-value: 2.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMH 183
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPIL--LLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 184 AMWSSWAPPLERSKLLSISYAAQ-----LGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLvsdtpqkhkris 258
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWalgalLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLRRRT------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 259 hyekeyilsslrnqlssqksvpwvpilkslplWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSW 338
Cdd:cd17316 180 --------------------------------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 339 LCMILSGQAADnlraKWNfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTIstTLGGFCSSGFSINHLDIAP 418
Cdd:cd17316 228 VGALIAGLLSD----RIG------RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLF--ILSFFVGGVWGALYAYLAE 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1843419856 419 SYA----GILLGITNTFATIPGMVGPVIAKSLTPdnTVGEWQTVFYIAAAINVFGAI 471
Cdd:cd17316 296 LFPtevrATGVGLSYNLGRLGGGGAPPLIALLLA--STGGTGVPALILALLAIVALI 350
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
44-476 |
3.44e-09 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 58.79 E-value: 3.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 44 ILAFFGFFIVYALRVNLSVALVDMVDSnttlednrtskacpehsapikvhhnqtgkkYQWDAETQGWILGSFFYGYIITQ 123
Cdd:cd17345 6 LGIFIGYAGYYLVRNNFSLAQPYLIEQ------------------------------YGLSKTEIGLIGSALSIAYGLSK 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 124 IPGGYVASKIGGKMLLGFGILGTAVLTLFTPIA--ADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSI 201
Cdd:cd17345 56 FVMGNLSDRSNPKRFLAIGLILSAIINILIGFVpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSI 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 202 SYAAQ-LGTVISLPLSGIICYYM---NWTYVFYFFGTIGIFWFLLWIWLVSDTPQKH--KRISHYEKEYILSSLRNQLSS 275
Cdd:cd17345 136 WNISHnVGGGLVGPLAGLGLAIFgdgWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEglPPIEEYKGDYPEEADGEEEEQ 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 276 QKSVP---WVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLR 352
Cdd:cd17345 216 ELSAWeifVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLF 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 353 AKwnfstlcvRRifSLIGMIgpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSG----FSINHLDIAPSYA-GILLGI 427
Cdd:cd17345 296 KG--------RR--APTGII--FMILVIVALIVYWLAPNVLVDLIALIALGFLIYGpvmlIGLQALELVPKKAaGTAAGL 363
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1843419856 428 TNTFATIPGMVGPVIAKSLTPDNTvgEWQTVFYIaAAINVFGAIFFTLF 476
Cdd:cd17345 364 TGLFGYLGGSVLATALIGIIVDHF--GWNGGFIV-LLASCILAIIFLAL 409
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
104-405 |
6.97e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 57.59 E-value: 6.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 104 DAETQGWILGSFFYGYIITqIP-GGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAM 182
Cdd:cd17503 29 SLDTVQWVITSYLLALAIM-IPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--LIIFRILQGFGGGVLIPLA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 183 HAMWSSWAPPLERSKLLSI-SYAAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLwiwlvsdTPqkhkrishye 261
Cdd:cd17503 106 QTILLRIYPPEKRGAAMGLvGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL-------AP---------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 262 keyiLSSLRnqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCM 341
Cdd:cd17503 169 ----LLDLR-------------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILS 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843419856 342 ILSGQAADnlraKWNFstlcvrRIFSLIGMIGPAVFLVAAGFIGCDYSlaVAFLTISTTLGGFC 405
Cdd:cd17503 232 PLVGRLLD----KFGP------RLLLLAGLLLLALGTLLLAFLTPDTS--LWLIILPLFIRGLG 283
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
109-332 |
1.70e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 56.47 E-value: 1.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADlgVGPLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--PWLFAIALVLTGFGGGLFEPASEAMIAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 189 WAPPLERSKLLSISYAAQ-LGTVISlPLSGIICYYMNWTYVFYF-FGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEyil 266
Cdd:cd17329 116 VTTPENRTRAFSLLYWAInLGVAIG-PLLGGLLLLYSFRLLFLAaAVLFLLAALVLLFLLPETRPKRRAAEKTEILR--- 191
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1843419856 267 sslrnqlssqksvPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSL 332
Cdd:cd17329 192 -------------GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLAL 244
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
107-473 |
2.17e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 56.09 E-value: 2.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 107 TQGWILGSFF-YGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAM 185
Cdd:cd17328 34 SLAGLLQTVFiISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--LLLFRALVGIGEASYSPIAPTI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 186 WSSWAPPLERSKLLSISYAA-QLGTVISLPLSGIIC-YYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKE 263
Cdd:cd17328 112 IADLFPKEKRTRALGVFYFAiPLGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 264 YILSSLRNqlssqksvpWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSlpYLGSWLCM-- 341
Cdd:cd17328 192 TATSFLAD---------LKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGL--IFGAITCIag 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 342 ----ILSGQAADNLRAKwnfstlcVRRIFSLIGMIG--PAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCS----SGFSI 411
Cdd:cd17328 261 vlgvLLGGILADRLRRK-------TPRADPLVCAVGllAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLnwapVFAIL 333
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1843419856 412 NHLDI----APSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGE-----WQTVFYIAAAINVFGAIFF 473
Cdd:cd17328 334 LYVVIptrrSTASAIQILLSHLLGDAGSPYLIGLISDLLRQNKDSPLaeaasLQYALLLCSFVLVLGGFFF 404
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
141-476 |
3.75e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.68 E-value: 3.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 141 FGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAP-----PLERSKLLSI-SYAAQLGTVISLP 214
Cdd:COG2211 86 IGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAeltpdYEERTRLSSWrFAFAGLGGLLASV 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 215 LSGIICYYM------NWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKrishyEKEYILSSLRNqlssqksvpwvpILKSL 288
Cdd:COG2211 166 LPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE-----EKVSLKESLKA------------LLKNR 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 289 PLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFstlcvrrifsL 368
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAF----------I 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 369 IGMIGPAVFLVAAGFIGcdySLAVAFLTISTTLGGFCSSGFSINHL----DIAP--------SYAGILLGITNTFATIPG 436
Cdd:COG2211 299 IGLLLAALGLLLLFFLG---PGNLWLLLVLAALAGIGLGAILVLPWamlaDVVDydewktgrRREGLYFGIFTFAIKLGQ 375
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1843419856 437 MVGPVI-----------AKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLF 476
Cdd:COG2211 376 ALAGALaglllalfgyvAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
293-476 |
7.56e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 54.35 E-value: 7.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 293 IVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRakwnfstlcvRRIFSLIGMI 372
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG----------RRRVLLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 373 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTpdnTV 452
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA---SL 147
|
170 180
....*....|....*....|....
gi 1843419856 453 GEWQTVFYIAAAINVFGAIFFTLF 476
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLLLLP 171
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
109-476 |
8.34e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.16 E-value: 8.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGP---LIVLRALEGLGEGVTFPAMHAM 185
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSlwlLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 186 WSSWAPPLERSKLLSI-SYAAQLGTVISLPLSGIICYYMNWTYVFYF-FGTIGIFWFLLWIWLVSDTPQKHKRISHYEKE 263
Cdd:cd06173 117 LPELVPKEQLVRANALnSLATQLARIIGPALGGLLVALLGPGGAFAInALSFLLSALLLLFIRRPPPAAPGESSSLLLRD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 264 YILSSLRnqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMIL 343
Cdd:cd06173 197 LREGLRY-------------LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 344 SGQAADNLRakwnfstlcvRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGI 423
Cdd:cd06173 264 LGRLSKRRR----------RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGR 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1843419856 424 LLGITNTFATIPGMVGPVIAKSLTPdntVGEWQTVFYIAAAINVFGAIFFTLF 476
Cdd:cd06173 334 VFSVYNALNSGAMPLGALLAGLLAD---ALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
104-472 |
1.05e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 53.72 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMH 183
Cdd:cd17321 29 SPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAF--LIAARALQGIGAAAIMPASL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 184 AMWSSWAPPLERSKLLSISYAAQ-LGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLwiwlvsdtpqkhkrishyek 262
Cdd:cd17321 107 ALIAATFPGERRGRALGLWGAVVgIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL-------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 263 eyilsslrnqlssqksvpwvpilkSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMI 342
Cdd:cd17321 167 ------------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 343 LSGQAADNLRAkwnfstlcvrRIFSLIGMIgpavfLVAAGFIG---CDYSLAVAFLTISTTLGGFCsSGFSINHLDIA-- 417
Cdd:cd17321 223 LAGRLADRFGP----------RLVLVAGLL-----LTAVGLLLlalLGADSSVWLLLPGLVLLGLG-LGLFATPLTNAal 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1843419856 418 ----PSYAGILLGITNTFATIPGMVGPVIAKSL--------------------TPDNTVGEWQTVFYIAAAINVFGAIF 472
Cdd:cd17321 287 ssvpKEKAGAASGILNTARQLGGALGVALLGALltaglsanlgdsgvaallsaAAAAFAAGFHLAFLVAAALALLAALL 365
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
109-475 |
1.37e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.48 E-value: 1.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIG-GKMLLGFGILGTAVLTLFTPiAADLGVgpLIVLRALEGLGEGVTFPAM----H 183
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGrRRTLILGLLLISLALALIFA-TPSIYL--FVVLMFLAGLGAGILDTGAntfvG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 184 AMWSSWAPplerSKLLSISYAAQLGTVISLPLSG-IICYYMNWTYVFYFFGTIGIFWFLLWIWLVSdtpqkhkrishyeK 262
Cdd:cd17333 111 ALFEESSA----TRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLLAILILLTLF-------------P 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 263 EYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMI 342
Cdd:cd17333 174 ELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 343 LSGQAADNLRAKwnfsTLCVrrIFSLIGMIGPAVFLVAAGFIGcdysLAVAFLTISTTLGGFCSSGFSINhLDIAPSYAG 422
Cdd:cd17333 254 LGGPISRRIKPH----TLLV--LSGSGALLGLLILLLAPTLVV----GLVATALLGLFMAALFPTILSLG-ISNLPYAKG 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1843419856 423 ILLGITNTFATIPGMVGPVIAKSLtpDNTVGEwQTVFYIaaaINVFGAIFFTL 475
Cdd:cd17333 323 KGTSVLLAAGSIGGAIIPFIMGFI--AEAVGI-QTAMLL---ITILYAIIFVL 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
99-252 |
7.44e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 7.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 99 KKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIG--GKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEG 176
Cdd:COG2271 209 EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPAL--AIALLFLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1843419856 177 VTFPAMHAMWSSWAPPLERSKLLSISY-AAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQ 252
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNtFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
110-257 |
3.92e-06 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 49.30 E-value: 3.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 110 WILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:TIGR00711 41 WVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLEL--MIIFRVIQGFGGGPLIPLSFSTLLNI 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 190 APPLERSKLLSI-SYAAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLL-WIWLVSDTPQKHKRI 257
Cdd:TIGR00711 119 YPPEKRGRAMAIwGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVaFFILPRDKPAASENF 188
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
100-206 |
4.76e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.43 E-value: 4.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 100 KYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTF 179
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWL--LLLALFLLGFGFGLLF 314
|
90 100
....*....|....*....|....*..
gi 1843419856 180 PAMHAMWSSWAPPLERSKLLSISYAAQ 206
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
127-473 |
4.98e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 48.71 E-value: 4.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 127 GYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSWAPPlERSKLLSI-SYAA 205
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWL--LLLLVALAGIGSAAFHPEGARLASQAAGG-RRGLAMSIfSVGG 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 206 QLGTVISlPLSGIICYYMNWTYVFYFFGTI-GIFWFLLWIWLVSDTPQKHKRishyekeyilsslRNQLSSQKSVPWVPI 284
Cdd:cd17478 129 NLGFALG-PLIAAALVALFGGLGLLILLIIpGLAVALLLLRLRPLKKPEAKK-------------AAAKSSARSTLKGVW 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 285 LKSLPLWAIVvahFSYNWTFYTLLTLLPTYMKEILrFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFstlcvrr 364
Cdd:cd17478 195 RALLLLLIIV---FLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVI------- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 365 ifsLIGMIGPAVFLVAAGFIGCDYSLAVAFLTisttlGGFCSSGFSINHL---DIAPSYAGILLGITNTFA-TIPGMVGP 440
Cdd:cd17478 264 ---IASLLLAAPFLLLFLLTPGIWSYILLVLA-----GFLLFASFPVTVVlaqELLPGNVGLASGLMMGLSfGLGGIGAP 335
|
330 340 350
....*....|....*....|....*....|....*.
gi 1843419856 441 VIAKsltpdntVGEW---QTVFYIAAAINVFGAIFF 473
Cdd:cd17478 336 VLGA-------LADAfglESVLLILALLPLLGALLA 364
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
111-252 |
1.07e-05 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 47.40 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 111 ILGSFFY-GYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:cd17488 42 ILGSLFYiTYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWA--FAVLWTLNAFFQGWGWPPCARLLTHW 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843419856 190 APPLERSKLLSI-SYAAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQ 252
Cdd:cd17488 120 YSRNERGFWWSIwNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAILMGIVLCWRLRDRPP 183
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
292-476 |
1.30e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 47.62 E-value: 1.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 292 AIVVAHFSYNWTFYTLLTLLPTYMKEILrfNVQENGFLSSLPYLGSWLCMILSGQAADnlrakwnfstLCVRRIFsligM 371
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLG--PSSNSTWISTAWSLAQAVLGPIVGRLSD----------LFGRRWF----F 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 372 IGPAVFLVAAGFIGCD----YSLAVAFLTISTTLGGFCSSGFSINHLdIAPSYAGILLGITNTFATIPGMVGPVIAKSLT 447
Cdd:cd06179 66 IGGNLLGVVGSIVAGTaksvNMLIGGQALIGIGAGTQGLGAAVASEL-VPNKYRGLVQGVVNLVASPGSALGPLIAGALV 144
|
170 180
....*....|....*....|....*....
gi 1843419856 448 PDNTVGeWQTVFYIAAAINVFGAIFFTLF 476
Cdd:cd06179 145 EANAAG-WRWIFYINAIFNALALILLFFF 172
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
109-465 |
1.42e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 47.21 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGeGVTFPAMhAMWSS 188
Cdd:cd17472 35 GLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYG--LILGRALQGSG-AISSVVM-ALLAD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 189 WAPPLERSK---LLSISYAaqLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLlWIWLVSDTPQKHKRISHYEKEYI 265
Cdd:cd17472 111 LTREENRTKamaLIGASIG--IAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLL-ILLFFVPDPPKIVQISEKEKKKL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 266 LSSLRNqlssqksvpwvPILKSLPLwAIVVAHFSYNWTFYtlltLLPTYMKEILRFNVQEngFLSSLP-YLGSWLCMILS 344
Cdd:cd17472 188 KKLLKN-----------KRLLRLDF-SIFILHFVLMAFFY----ILPLLLTQLGGGKGQL--WKVYLPaILIGFILMVPF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 345 GQAADNLRAKWN---FSTLCVRRIFSLIGMIGPAVFLVAAGFIGcdysLAVAFLTISTTLGGFcssgfsINHLdIAPSYA 421
Cdd:cd17472 250 VIYAEKKGKMKQvfvSSILLIAVGFLLLLFAATSLWLLIIGLII----FFIGFNLLEALLPSL------VSKI-APKEYR 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1843419856 422 GILLGITNTFATIPGMVGPVIAKSLtpdNTVGEWQTVFYIAAAI 465
Cdd:cd17472 319 GTAMGIYNTSQFLGSFLGGALGGLL---WGLLGYSSVFLTILIL 359
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
280-476 |
2.08e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.51 E-value: 2.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 280 PWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEiLRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFst 359
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 360 lcvrrifsLIGMIGPAVFLVAAGFigcdySLAVAFLTISTTLGGFCSSGFSINHLDIAPSYA-----GILLGITNTFATI 434
Cdd:COG2814 79 --------LLGLLLFALGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLVpperrGRALGLLGAGLGL 145
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1843419856 435 PGMVGPVIAKSLTpdnTVGEWQTVFYIAAAINVFGAIFFTLF 476
Cdd:COG2814 146 GPALGPLLGGLLA---DLFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
293-476 |
4.72e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.50 E-value: 4.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 293 IVVAHFSYNWTFYTLLTLLPTYMKEILrFNVQENGFLSSLPYLGSWLCMILSGQAADNLRakwnfstlcvRRIFSLIGMI 372
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFG-LSASQLGLLFALFSLGYALLQPLAGLLADRFG----------RRPVLLLGLL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 373 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAkSLTPDNTV 452
Cdd:cd06174 70 LFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLG-GILASSLG 148
|
170 180
....*....|....*....|....
gi 1843419856 453 GEWQTVFYIAAAINVFGAIFFTLF 476
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLLLV 172
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
108-252 |
8.88e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 44.56 E-value: 8.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 108 QGWILGSffygYIITQ----IPGGYVASKIGGKMLLgfgILGTAVLTLFTPIAadlGVGP----LIVLRALEGLGEGVTF 179
Cdd:cd17476 35 LSWLAAS----YSLTVgtfiLIFGRLGDIYGHKKMF---VIGSFWFAIWSLIA---GFSPnfifFIICRALQGLGPAFLL 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1843419856 180 P-AMHAMWSSWAPPLERSKLLSI-SYAAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLL-WIWLVSDTPQ 252
Cdd:cd17476 105 PnAMALLGRTYPPGPRKNIVFSLfGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAaIFWTSPSFIA 180
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
110-404 |
1.05e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 44.49 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 110 WILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:cd17320 38 LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--LLIARFLQGLGAAAGSVVARAIVRDL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 190 APPLERSKLLS-ISYAAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRIshyekeyilSS 268
Cdd:cd17320 116 YSGAELAKIFSlLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRK---------PL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 269 LRNQLSSQKSVpwvpiLKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGswlcMILSGQAA 348
Cdd:cd17320 187 LSSLLRAYKRV-----LKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIA----LILGSLLN 257
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1843419856 349 DNLRAKWNFSTLCvrrIFSLIGMIGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGF 404
Cdd:cd17320 258 GRLVRRFGPRRLL---RLGLLLLLAAALVLLLAALLG-GLSLWPLVAPLFLIFFGF 309
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
109-395 |
1.40e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.09 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWV--WFLLRFVMGIGLAGLFVVSESWLNA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 189 WAPPLERSKLLSISYAAQLGTVISLPLSGIICYYMNWTyvfyFFGTIGIFwFLLWIWLVSDTPQKHKRISHYEKeyilss 268
Cdd:cd17477 112 LATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL----PFLIAAVL-LLLALVPLLLTRRAAPEIEEAES------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 269 lrnqlssqksVPWVPILKSLPLwaIVVAHFSYNWTFYTLLTLLPTYMKEILrFNVQENGFLSSLPYLGSWLCMILSGQAA 348
Cdd:cd17477 181 ----------ISLRRLLRIAPL--ALLGAFVAGFLEGAFYSLLPLYGLRLG-LSVAQAALLLAAFVLGGLLLQWPLGWLA 247
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1843419856 349 DNLRAKWnfstlcVRRIFSLIGMIGP--------------AVFLVAAGFIGCDYSLAVAFL 395
Cdd:cd17477 248 DRFDRRR------VLLGCALLGALAAlllplvpglplallVLLFLWGGAAGPLYTLALALA 302
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
104-248 |
2.42e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 43.34 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMH 183
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ--LALLRFLTGLGLGAAMPNAI 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1843419856 184 AMWSSWAPPLERSKLLSISYAA-QLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFL-----LWIWLVS 248
Cdd:cd17365 110 TLVSEYAPARRRSLAVTLMFCGyPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPllrgtLLLWVTF 180
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
109-252 |
2.52e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 43.41 E-value: 2.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVTFPAMHAMWSS 188
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--LLVARLLTGVGLGGALPNLIALTSE 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1843419856 189 WAPPLERSKLLSISYA-----AQLGTVISLPLSGiicyYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQ 252
Cdd:PRK11551 131 AVGPRLRGTAVSLMYCgvpfgGALASVIGVLAAG----DAAWRHIFYVGGVGPLLLVPLLMRWLPESRA 195
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
290-478 |
4.15e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.58 E-value: 4.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 290 LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWnfstlCVRRIFSLI 369
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRW-----GRRRPWILI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 370 GMIGPAVFLVAAGFI-GCDYSLAVAFLTISTTLGGFCSSGFSINHL----DIAPSYA--GILLGITNTFATIPGMVGPVI 442
Cdd:COG2211 87 GAIPLALSFVLLFTApDLSPTGKLIYALVTYLLLGLAYTLVNIPYSalgaELTPDYEerTRLSSWRFAFAGLGGLLASVL 166
|
170 180 190
....*....|....*....|....*....|....*....
gi 1843419856 443 AKSLTP---DNTVGEWQTVFYIAAAINVFGAIFFTLFAK 478
Cdd:COG2211 167 PPPLVAafgGDAALGYRLTALIFAVLGLLAFLLTFFGTK 205
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
293-478 |
4.42e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 42.56 E-value: 4.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 293 IVVAHFSYNWTFYTLLTLLPTYMKEiLRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRakwnfstlcvRRIFSLIGMI 372
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG----------RKRLLLLGLL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 373 GPAVFLVAAGFIGcdyslAVAFLTISTTLGGFCSSGFSINHL----DIAPS-YAGILLGITNTFATIPGMVGPVIAKSLT 447
Cdd:cd17325 70 LLAVSTLLFAFAT-----SYWQLLLARFLQGLASAAVWPAAMaliaDIAPPeERGRAMGIFSSAIGLGFLIGPLLGGLLA 144
|
170 180 190
....*....|....*....|....*....|.
gi 1843419856 448 pdnTVGEWQTVFYIAAAINVFGAIFFTLFAK 478
Cdd:cd17325 145 ---DALGYRAPFLVCAALALLALVLALLLLP 172
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
100-242 |
6.72e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.79 E-value: 6.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 100 KYQWDAETQGWILGSFFYGYIITQIP-GGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVlrALEGLGEGVT 178
Cdd:cd17330 204 RFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAA--AILAFGTGIV 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1843419856 179 FPAMHAMWSSWAPPLERSKLLSISYAAQLGTVISLPLSGIICYYMNWTYVFYFFG----TIGIFWFLL 242
Cdd:cd17330 282 FPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAagllLIALFLLSL 349
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
304-476 |
1.02e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.41 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 304 FYTLLTLLPTYMKEILRFNVQ--ENGFLSSLPYLGSWLCMILSGQAADnlraKWNfstlcvRRIFSLIGMIGpavflVAA 381
Cdd:cd17330 12 FGIVFPVLPFYVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSD----RYG------RKPVLLLSLAG-----SAV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 382 GFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIA----PSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVgewQT 457
Cdd:cd17330 77 SYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIAditdEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGY---AL 153
|
170
....*....|....*....
gi 1843419856 458 VFYIAAAINVFGAIFFTLF 476
Cdd:cd17330 154 PFLVAAALALLNLVLVLFF 172
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
109-473 |
1.23e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.02 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGeGVTFPAMHAMWSS 188
Cdd:cd17330 37 GLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWL--LFLARFLDGLT-GGNVSVAQAYIAD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 189 WAPPLERSKLLS-ISYAAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSdtpqkhkrishyekeyils 267
Cdd:cd17330 114 ITDEEERAKAFGiISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 268 slrnqlssqksvpwvpilkslPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLpylgSWLCMILSgQA 347
Cdd:cd17330 175 ---------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLAL----VGIAGILA-QL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 348 ADNLRAKWNFSTLCVRRIFSLIGMIGpavfLVAAGFIGcDYSLAVAFLTISTTLGGFCSSGF-SINHLDIAPSYAGILLG 426
Cdd:cd17330 229 LLIPRLAKRLGERKLLRLGLLLAIIG----LLLLPFAS-SVPLLVLAAAILAFGTGIVFPALsALLSKSVPSKEQGKAQG 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1843419856 427 ITNTFATIPGMVGPVIAKSLTpDNTVGEWqtVFYIAAAINVFGAIFF 473
Cdd:cd17330 304 IIQSLQSLARIIGPLLAGPLY-SFLGPGV--PFLLAAGLLLIALFLL 347
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
112-325 |
1.23e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 41.21 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 112 LGSFFYGYIITQIPG---GYVASKIGGK--MLLGFGILGTAVLTL-FTPIAADLGV-GPLIVL--RALEGLGEGVTFPAM 182
Cdd:cd17368 43 FATFGVGFFMRPIGAivlGAYADRIGRKpaMTLTLAIMALGTLLIaLAPTYATIGIaAPLLVLlaRLLQGFAAGGEVGGV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 183 HAMWSSWAPPLER---------SKLLSISYAAQLGTVISLPLSGIICYYMNWTYVFyFFGTIgIFWFLLWIWL-VSDTPQ 252
Cdd:cd17368 123 TAYLVEAAPPGRRgfytswqsaSQQVAIVAGALVGYLLSLTLTAEALAEWGWRIPF-FIGLL-IIPLGLWLRRsLEETEA 200
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1843419856 253 KHKRISHYEKEYILSSLRNqlssqksvPWVPILKSLPLWAIVVAhfsynwTFYTLLTLLPTYMKEILRFNVQE 325
Cdd:cd17368 201 FLERKARPTRRELFALLAN--------NRRIILLGMLLVAGSTV------TFYFTTVYTPTYAKTVLGLSARD 259
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
288-476 |
1.77e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.61 E-value: 1.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 288 LPLWAIVVAHFSYNWTFYTLLTLLPtYMKEILRFNVQENGFLSSLPYLGSWLCMILSGqaadnlrakwnfstLCVRRIFS 367
Cdd:COG0738 8 RALIAIYLLFFLWGFATALWGPLIP-ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAG--------------RLIDRFGY 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 368 LIGMIGpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGF--SINHL--DIAPSYAGILLGITNTFATIPGMVGPVIA 443
Cdd:COG0738 73 KRGLLL-GLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLdvAANPYvaALGPETAASRLNLLHAFFSLGALLGPLLG 151
|
170 180 190
....*....|....*....|....*....|...
gi 1843419856 444 KSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLF 476
Cdd:COG0738 152 GLLILLGLSLSWHLPYLILAVLLLLLALLFLRS 184
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
124-473 |
2.77e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.93 E-value: 2.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 124 IPGGYVASKIGGKMLLGFGILGTAVLTLFTpIAADLGVGPLIVLRALEGLGeGVTFPAMHAMWSSWAPPLERSKLLSISY 203
Cdd:cd17341 52 LPYGFLCDRFGGRRVFIASLLLLLIPLLAL-ALAVSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 204 AA-QLGTVIS----LPLSGIICY---YMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKhkrishyeKEYILSSLRnqlss 275
Cdd:cd17341 130 GAgNMGVAVSqllaPLIAGAIVFdggFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTG--------KASALEFLK----- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 276 qksvPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADnlraKW 355
Cdd:cd17341 197 ----VQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSD----RF 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 356 NFStlcVRRIFSLIGMIGPAVFLVAAGFIgcDYSLAVAFLTISTTLGGFCSSGF-SINHL--DIAPSYAGILLGITNTFA 432
Cdd:cd17341 269 GGR---RRLWWLFIVMTIGAALLSLSLPT--SGTNLVLFLALFVALGLGAGAGNgSVFRMvpFIFRRELGAVTGLVGAIG 343
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1843419856 433 TIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFF 473
Cdd:cd17341 344 GLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
109-271 |
3.06e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.90 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILGSFFYGYIITQIPGGYVASKIGG-KMLLGFGILGTAVLTLFTPIAADlgVGPLIVLRALEGLGEG--VTFPAMHAm 185
Cdd:cd17490 34 GIILGAYGISQMLLRIPLGILSDRIGKrKLFIIIGLLFTVLASLIMILFPS--PWGLLIARFLSGIAAAtwVSFTVLYA- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 186 wsSWAPPLERSKLLS-ISYAAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRIShyEKEY 264
Cdd:cd17490 111 --SYFPPDEAAKAMGlINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLT--ELKE 186
|
....*..
gi 1843419856 265 ILSSLRN 271
Cdd:cd17490 187 LLSVLKD 193
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
99-329 |
3.47e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 39.67 E-value: 3.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 99 KKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVT 178
Cdd:TIGR00710 33 ADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIET--LLVLRFVQAFGASAG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 179 FPAMHAMWSSWAPPLERSKLLSIsyaaqLGTVISLP------LSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQ 252
Cdd:TIGR00710 111 SVISQALVRDIYPGEELSRIYSI-----LMPVLALApavaplLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLP 185
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1843419856 253 KHKRIShyekeyilsslrnqlSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFL 329
Cdd:TIGR00710 186 YEARIQ---------------ISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLL 247
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
109-255 |
4.45e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 4.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 109 GWILG-SFFYGYIItQIPGGYVASKIGG-KMLLGFGILGTAVLTLFtpIAADLGVGPLIVLRALEGLGEGVTFPAMHAMW 186
Cdd:cd17370 37 GLIEGlAEALGSLL-RLFSGYLSDRTGKrKPLVILGYGLSALAKPL--LALAGSWQLVLLLRILERLGKGIRTPPRDALL 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1843419856 187 SSWAPPLERSKLLSISYAA-QLGTVISLPLSGIICYYMNWTY--VFYFFGTIGIFWFLLWIWLVSDTPQKHK 255
Cdd:cd17370 114 ADATPPSGRGKAFGLHRALdTLGAVLGPLLAALLLYLLGGNYrtIFLLAAIPALLALLILLFVVKEYPRPPK 185
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
102-476 |
5.27e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.21 E-value: 5.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 102 QWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTpiAADLGVGPLIVLRALEGLGEGVTFPA 181
Cdd:cd06180 30 GLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAM--ALTSGFAALLALRFLAGAASAFVFVF 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 182 MHAMWSSWAPPLERSKLLSISYAaqlGTVISLPLSGIICYYM-----NWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKR 256
Cdd:cd06180 108 GSNLVLHHATAAGRGHLIGLLFA---GVGLGIALSGLLVPAGlggglSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 257 IShyekeyilsslrnqlSSQKSVPWVpilksLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQEnGFLSSLPYLG 336
Cdd:cd06180 185 AS---------------AAESAPGLN-----RPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLA-GLLWSLFGLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 337 SWLCMILSGQAADNLRAKWNFS-TLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLaVAFLTISTTLGGfcssgfsinhlD 415
Cdd:cd06180 244 AVPSCFLWGALSDRWGTRRALAaNLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTF-MAITALVMALAR-----------E 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1843419856 416 IAPSYAGILLGITNTFATIPGMVGPVIAkSLTPDNTvGEWQTVFYIAAAINVFGAIFFTLF 476
Cdd:cd06180 312 LAPPAAPRALALMTASFGVGQILGPLLA-GWLADAT-GGFAPALILAAAALVVAALLALLV 370
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
136-472 |
5.60e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.10 E-value: 5.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 136 KMLLGFGILgTAVLTLFTPIAADLGVgpLIVLRALEGLGEGVtFP-AMHAMWSSWAPPLERSKLLSISYAAQLGTVISLP 214
Cdd:cd17504 62 KVLLIVLAI-YTAGSLLAAFAPNLPV--LIAGRALQGIGGAV-FPlAFALVREEFPPERVPVAQGILSATFGIGAGIGLP 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 215 LSGIICYYMNWTYVFYFFGTIGIFWFLLwiwlvsdtpqkhkrishyekeyilsslrnqlssqksVPWVPI--LKSLPLWA 292
Cdd:cd17504 138 LGGWIVQHLGWRWIFWTAAPVAVLLAAL------------------------------------VPLIDLrlLRRRNVLL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 293 IVVAHFSYNWTFYTLLTLLPTYMKE----ILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFstlcvrrifsL 368
Cdd:cd17504 182 ANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL----------L 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 369 IGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFsINHLDIA--PSYAGILLGITNTFATIPGMVGPVIA--- 443
Cdd:cd17504 252 IGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASL-PNIVVESvpPDRTGIATGMNTVLRTIGSAIGPAIAgai 330
|
330 340 350
....*....|....*....|....*....|....*.
gi 1843419856 444 -KSLTPDNTVGE------WQTVFYIAAAINVFGAIF 472
Cdd:cd17504 331 lTTYTVSITSGGvptegaYVLAFLIGAALALAALLL 366
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
110-470 |
7.41e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.55 E-value: 7.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 110 WILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIaADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSW 189
Cdd:cd17314 42 TAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSY-VFNSFPLSYACFVFIGAGTGILYGSAVLVTTQY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 190 APPLERSKLLSISYAAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSL 269
Cdd:cd17314 121 FPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 270 RnqlssqksvpwvpILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAAD 349
Cdd:cd17314 201 E-------------IFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKLMSIYGLFNAFGRLLWGIVAD 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 350 NLRAKwnFSTLCVRRIFSLIGMIgpaVFLVAAGFIGCDYSLAVAFLTISTtlGGFCSSGFSINHLDIAPSYAGILLGITN 429
Cdd:cd17314 268 FFGGR--LSTLSILLTILGLGLC---AFLFLLKMTPVGLVLTGSLLGFSY--GGLFTVYPATVSTVFGTESFATLYGILL 340
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1843419856 430 TFATIPGMVGPVIAKSLTpdNTVGEWQTVFYIAAAINVFGA 470
Cdd:cd17314 341 FAPAIGSILGPMLGAKFY--DRTPSYISAVYIYAVIVFLAS 379
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
290-478 |
8.08e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.71 E-value: 8.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 290 LWAIVVAhFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCvrrIFSLI 369
Cdd:COG2223 7 LLLATLA-FFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL---LLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843419856 370 GMIG------PAVFLVAAGFIGCdySLAVAFLTISTTLGGFcssgfsinhldIAPSYAGILLGITNTFatipGMVGPVIA 443
Cdd:COG2223 83 GLLLlalavsYWLLLLLGLLLGI--GGGGSFAVGIALVSKW-----------FPPDRRGLALGLAAGG----GNLGAAVA 145
|
170 180 190
....*....|....*....|....*....|....*..
gi 1843419856 444 KSLTP--DNTVGeWQTVFYIAAAINVFGAIFFTLFAK 478
Cdd:COG2223 146 AFLAPllIAAFG-WRNAFLILGILLLVVAVLAWLFLR 181
|
|
| |
