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Conserved domains on  [gi|1843978441|ref|NP_001369700|]
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interleukin-6 receptor subunit alpha isoform 6 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgC2_D1_IL-6RA cd20939
Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as ...
 34-110 1.11e-44

Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains; The members here are composed of the immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126). The IL-6RA ectodomain, which is highly modular, consisting of three domains (D1, D2, and D3). Interleukin-6 (IL-6) is a multifunctional cytokine that regulates the immune response, hemopoiesis, the acute phase response and inflammation. It is generated in an infectious lesion and sends out a warning signal to the entire body. IL-6 binds first to its cognate alpha-chain receptor (IL-6R), and then the IL-6/IL-6R complex which in turn induces homodimerization of gp130. As a result, a high-affinity functional receptor complex of IL-6, IL-6R and gp130 is formed, and subsequently the complex triggers a downstream signal cascade. Aberrant production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains. Unlike other Ig domain sets, the C2-set lacks the D strand.


:

Pssm-ID: 409533  Cd Length: 77  Bit Score: 151.27  E-value: 1.11e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1843978441  34 VLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLV 110
Cdd:cd20939     1 VLTSLPGASVTLTCPGVEPEDNATIHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLSDSGNYSCYRAGRPAGTVHLLV 77
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 118-213 1.74e-25

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


:

Pssm-ID: 401252  Cd Length: 96  Bit Score: 99.79  E-value: 1.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978441 118 QLSCFRKSPlSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAedfqEPCQYSQES--QKFSCQLAVPEGD-SSFYIVSMCV 194
Cdd:pfam09240   1 DLTCFIHNP-SNLSCEWKPGPNAPPDTNYVLYVRKSPLGPV----LQCQYYIRDdgTRIGCQFDDLEGLsSSFHQVYICV 75

                          90       100
                  ....*....|....*....|.
gi 1843978441 195 --ASSVGSKFSKTQTFQGCGI 213
Cdd:pfam09240  76 ngSSSAGPIRSSDQTFQLQNI 96
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 216-308 3.40e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978441 216 PDPPANITVTAVarNPRWLSVTWQDPHSWNSSFyrLRFELRYRAERSKTFTTWMVKDL-QHHCVIHDAWSGLRHVVQLRA 294
Cdd:cd00063     1 PSPPTNLRVTDV--TSTSVTLSWTPPEDDGGPI--TGYVVEYREKGSGDWKEVEVTPGsETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....
gi 1843978441 295 QEEFGQGEWSEWSP 308
Cdd:cd00063    77 VNGGGESPPSESVT 90
 
Name Accession Description Interval E-value
IgC2_D1_IL-6RA cd20939
Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as ...
 34-110 1.11e-44

Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains; The members here are composed of the immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126). The IL-6RA ectodomain, which is highly modular, consisting of three domains (D1, D2, and D3). Interleukin-6 (IL-6) is a multifunctional cytokine that regulates the immune response, hemopoiesis, the acute phase response and inflammation. It is generated in an infectious lesion and sends out a warning signal to the entire body. IL-6 binds first to its cognate alpha-chain receptor (IL-6R), and then the IL-6/IL-6R complex which in turn induces homodimerization of gp130. As a result, a high-affinity functional receptor complex of IL-6, IL-6R and gp130 is formed, and subsequently the complex triggers a downstream signal cascade. Aberrant production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409533  Cd Length: 77  Bit Score: 151.27  E-value: 1.11e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1843978441  34 VLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLV 110
Cdd:cd20939     1 VLTSLPGASVTLTCPGVEPEDNATIHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLSDSGNYSCYRAGRPAGTVHLLV 77
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 118-213 1.74e-25

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 99.79  E-value: 1.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978441 118 QLSCFRKSPlSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAedfqEPCQYSQES--QKFSCQLAVPEGD-SSFYIVSMCV 194
Cdd:pfam09240   1 DLTCFIHNP-SNLSCEWKPGPNAPPDTNYVLYVRKSPLGPV----LQCQYYIRDdgTRIGCQFDDLEGLsSSFHQVYICV 75

                          90       100
                  ....*....|....*....|.
gi 1843978441 195 --ASSVGSKFSKTQTFQGCGI 213
Cdd:pfam09240  76 ngSSSAGPIRSSDQTFQLQNI 96
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 216-308 3.40e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978441 216 PDPPANITVTAVarNPRWLSVTWQDPHSWNSSFyrLRFELRYRAERSKTFTTWMVKDL-QHHCVIHDAWSGLRHVVQLRA 294
Cdd:cd00063     1 PSPPTNLRVTDV--TSTSVTLSWTPPEDDGGPI--TGYVVEYREKGSGDWKEVEVTPGsETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....
gi 1843978441 295 QEEFGQGEWSEWSP 308
Cdd:cd00063    77 VNGGGESPPSESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 216-301 2.14e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978441  216 PDPPANITVTAVarNPRWLSVTWQDPHSWNSSFYRLRFELRYRaERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQ 295
Cdd:smart00060   1 PSPPSNLRVTDV--TSTSVTLSWEPPPDDGITGYIVGYRVEYR-EEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*.
gi 1843978441  296 EEFGQG 301
Cdd:smart00060  78 NGAGEG 83
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 30-97 3.81e-07

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 47.96  E-value: 3.81e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843978441  30 VARGVLTSLPGDSVTLTCPGVEPEDNATVHWvlRKPAAGSHPSRWAGMGRR------LLLRSVQLHDSGNYSCY 97
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTW--SKEGGTLIESLKVKHDNGrttqssLLISNVTKEDAGTYTCV 72
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 33-110 7.57e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.03  E-value: 7.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978441   33 GVLTSLPGDSVTLTCPgVEPEDNATVHWVLRKPAAGSHPSR----WAGMGRRLLLRSVQLHDSGNYSC---YRAGRPAGT 105
Cdd:smart00410   2 PSVTVKEGESVTLSCE-ASGSPPPEVTWYKQGGKLLAESGRfsvsRSGSTSTLTISNVTPEDSGTYTCaatNSSGSASSG 80


                   ....*
gi 1843978441  106 VHLLV 110
Cdd:smart00410  81 TTLTV 85
 
Name Accession Description Interval E-value
IgC2_D1_IL-6RA cd20939
Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as ...
 34-110 1.11e-44

Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains; The members here are composed of the immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126). The IL-6RA ectodomain, which is highly modular, consisting of three domains (D1, D2, and D3). Interleukin-6 (IL-6) is a multifunctional cytokine that regulates the immune response, hemopoiesis, the acute phase response and inflammation. It is generated in an infectious lesion and sends out a warning signal to the entire body. IL-6 binds first to its cognate alpha-chain receptor (IL-6R), and then the IL-6/IL-6R complex which in turn induces homodimerization of gp130. As a result, a high-affinity functional receptor complex of IL-6, IL-6R and gp130 is formed, and subsequently the complex triggers a downstream signal cascade. Aberrant production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409533  Cd Length: 77  Bit Score: 151.27  E-value: 1.11e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1843978441  34 VLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLV 110
Cdd:cd20939     1 VLTSLPGASVTLTCPGVEPEDNATIHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLSDSGNYSCYRAGRPAGTVHLLV 77
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 118-213 1.74e-25

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 99.79  E-value: 1.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978441 118 QLSCFRKSPlSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAedfqEPCQYSQES--QKFSCQLAVPEGD-SSFYIVSMCV 194
Cdd:pfam09240   1 DLTCFIHNP-SNLSCEWKPGPNAPPDTNYVLYVRKSPLGPV----LQCQYYIRDdgTRIGCQFDDLEGLsSSFHQVYICV 75

                          90       100
                  ....*....|....*....|.
gi 1843978441 195 --ASSVGSKFSKTQTFQGCGI 213
Cdd:pfam09240  76 ngSSSAGPIRSSDQTFQLQNI 96
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 216-308 3.40e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978441 216 PDPPANITVTAVarNPRWLSVTWQDPHSWNSSFyrLRFELRYRAERSKTFTTWMVKDL-QHHCVIHDAWSGLRHVVQLRA 294
Cdd:cd00063     1 PSPPTNLRVTDV--TSTSVTLSWTPPEDDGGPI--TGYVVEYREKGSGDWKEVEVTPGsETSYTLTGLKPGTEYEFRVRA 76

                          90
                  ....*....|....
gi 1843978441 295 QEEFGQGEWSEWSP 308
Cdd:cd00063    77 VNGGGESPPSESVT 90
Ig_Semaphorin_C cd04979
Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are ...
 35-112 2.03e-07

Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are composed of the immunoglobulin (Ig)-like domain in semaphorins. Semaphorins are transmembrane protein that have important roles in a variety of tissues. Functionally, semaphorins were initially characterized for their importance in the development of the nervous system and in axonal guidance. Later they have been found to be important for the formation and functioning of the cardiovascular, endocrine, gastrointestinal, hepatic, immune, musculoskeletal, renal, reproductive, and respiratory systems. Semaphorins function through binding to their receptors and transmembrane semaphorins also serves as receptors themselves. Although molecular mechanism of semaphorins is poorly understood, the Ig-like domains may be involved in ligand binding or dimerization.


Pssm-ID: 409368  Cd Length: 88  Bit Score: 48.61  E-value: 2.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978441  35 LTSLPGDSVTLTCPgvEPEDNATVHWVL-RKPAAGSHPSRWAGMGRR-LLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDV 112
Cdd:cd04979     6 ISVKEGDTVILSCS--VKSNNAPVTWIHnGKKVPRYRSPRLVLKTERgLLIRSAQEADAGVYECHSGERVLGSTLRSVTL 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 216-301 2.14e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978441  216 PDPPANITVTAVarNPRWLSVTWQDPHSWNSSFYRLRFELRYRaERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQ 295
Cdd:smart00060   1 PSPPSNLRVTDV--TSTSVTLSWEPPPDDGITGYIVGYRVEYR-EEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*.
gi 1843978441  296 EEFGQG 301
Cdd:smart00060  78 NGAGEG 83
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 30-97 3.81e-07

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 47.96  E-value: 3.81e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843978441  30 VARGVLTSLPGDSVTLTCPGVEPEDNATVHWvlRKPAAGSHPSRWAGMGRR------LLLRSVQLHDSGNYSCY 97
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTW--SKEGGTLIESLKVKHDNGrttqssLLISNVTKEDAGTYTCV 72
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 33-110 7.57e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.03  E-value: 7.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1843978441   33 GVLTSLPGDSVTLTCPgVEPEDNATVHWVLRKPAAGSHPSR----WAGMGRRLLLRSVQLHDSGNYSC---YRAGRPAGT 105
Cdd:smart00410   2 PSVTVKEGESVTLSCE-ASGSPPPEVTWYKQGGKLLAESGRfsvsRSGSTSTLTISNVTPEDSGTYTCaatNSSGSASSG 80


                   ....*
gi 1843978441  106 VHLLV 110
Cdd:smart00410  81 TTLTV 85
Ig_Sema3 cd05871
Immunoglobulin (Ig)-like domain of class III semaphorin Sema3; The members here are composed ...
 40-96 3.96e-05

Immunoglobulin (Ig)-like domain of class III semaphorin Sema3; The members here are composed of the immunoglobulin (Ig)-like domain of Sema3 and similar proteins. Semaphorins are classified based on structural features additional to the Sema domain. Sema3 is a Class III semaphorin that is secreted. It is a vertebrate class having a Sema domain, an Ig domain, a short basic domain. They have been shown to be axonal guidance cues and have a part in the regulation of the cardiovascular, immune, and respiratory systems. Sema3A, the prototype member of this class III subfamily, induces growth cone collapse and is an inhibitor of axonal sprouting. In perinatal rat cortex, it acts as a chemoattractant and functions to direct the orientated extension of apical dendrites. It may play a role, prior to the development of apical dendrites, in signaling the radial migration of newborn cortical neurons towards the upper layers. Sema3A selectively inhibits vascular endothelial growth factor receptor (VEGF)-induced angiogenesis and induces microvascular permeability. This group also includes Sema3B, -C, -D, -E, -G.


Pssm-ID: 409455  Cd Length: 92  Bit Score: 42.33  E-value: 3.96e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1843978441  40 GDSVTLTCPGVEPEdnATVHWVLRKPAaGSHPS------RWAGMGRRLLLRSVQLHDSGNYSC 96
Cdd:cd05871    12 GNSTFLECLPKSPQ--ATVKWLFQRGG-DQRKEevkseeRLIVTDRGLLLRSLQRSDAGVYTC 71
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 36-96 4.43e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.09  E-value: 4.43e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1843978441  36 TSLPGDSVTLTCpGVEPEDNATVHWVLRKPAAGSHPSRWA---GMGRRLLLRSVQLHDSGNYSC 96
Cdd:pfam13927  12 TVREGETVTLTC-EATGSPPPTITWYKNGEPISSGSTRSRslsGSNSTLTISNVTRSDAGTYTC 74
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 43-96 2.35e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.54  E-value: 2.35e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1843978441  43 VTLTCPgVEPEDNATVHWVL---RKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC 96
Cdd:cd00096     1 VTLTCS-ASGNPPPTITWYKngkPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTC 56
Ig2_IL1R-like cd05757
Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; ...
 44-96 9.82e-03

Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R; also known as cluster of differentiation (CD) 121). IL-1 alpha and IL-1 beta are cytokines which participate in the regulation of inflammation, immune responses, and hematopoiesis. These cytokines bind to the IL-1 receptor type 1 (IL1R1), which is activated on additional association with interleukin-1 receptor accessory protein (IL1RAP). IL-1 also binds a second receptor designated type II (IL1R2). Mature IL1R1 consists of three IG-like domains, a transmembrane domain, and a large cytoplasmic domain. Mature IL1R2 is organized similarly except that it has a short cytoplasmic domain. The latter does not initiate signal transduction. A naturally occurring cytokine IL-1RA (IL-1 receptor antagonist) is widely expressed and binds to IL-1 receptors, inhibiting the binding of IL-1 alpha and IL-1 beta. This group also contains ILIR-like 1 (IL1R1L) which maps to the same chromosomal location as IL1R1 and IL1R2.


Pssm-ID: 409415  Cd Length: 92  Bit Score: 35.38  E-value: 9.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1843978441  44 TLTCPGVEP----EDNATVHWVLR-KPAAGshPSRWAGMGRRLLLRSVQLHDSGNYSC 96
Cdd:cd05757    14 KITCPDLDDykneNVLPPIQWYKDcKPLQG--DKRFIPKGSKLLIQNVTEEDAGNYTC 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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