Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1858589277 105 KDPTFVCSGCSFLAKTPEGLSLHNATCHSGEASFVWNVAKPDNHVVVEQSI 155
Cdd:pfam18387   1 ADPSFVCVECGFLAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSL 51

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1858589277  621 PEQLRALESSFAQNPLPLDEELDRLRSETKMTRREIDSWFSERRKK 666
Cdd:smart00389  10 PEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1858589277 769 CKKTAQQRHLLRQLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQ 823
Cdd:cd00086     5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1858589277 105 KDPTFVCSGCSFLAKTPEGLSLHNATCHSGEASFVWNVAKPDNHVVVEQSI 155
Cdd:pfam18387   1 ADPSFVCVECGFLAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSL 51

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1858589277  497 YKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCR 550
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1858589277 621 PEQLRALESSFAQNPLPLDEELDRLRSETKMTRREIDSWFSERRKK 666
Cdd:cd00086     9 PEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAK 54

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1858589277  317 SFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQ 359
Cdd:smart00389  14 EELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1858589277 850 LQDYYMTHKMLYEEDLQNLCDKTQMSSQQVKQWFAEK 886
Cdd:pfam11569  14 LEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASR 50

Homeodomain;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1858589277 502 SHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRR 546
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52

Homeodomain;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1858589277 319 LKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQ 359
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1858589277 105 KDPTFVCSGCSFLAKTPEGLSLHNATCHSGEASFVWNVAKPDNHVVVEQSI 155
Cdd:pfam18387   1 ADPSFVCVECGFLAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSL 51

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1858589277  497 YKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRRYHCR 550
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1858589277 621 PEQLRALESSFAQNPLPLDEELDRLRSETKMTRREIDSWFSERRKK 666
Cdd:cd00086     9 PEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAK 54

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1858589277  317 SFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQ 359
Cdd:smart00389  14 EELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1858589277 850 LQDYYMTHKMLYEEDLQNLCDKTQMSSQQVKQWFAEK 886
Cdd:pfam11569  14 LEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASR 50

Homeodomain;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1858589277 502 SHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRKWFSDRR 546
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52

Homeodomain;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1858589277 319 LKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQ 359
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55