NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1858900822|ref|NP_001371295|]
View 

zinc finger protein 319 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-349 6.07e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 192 VTPAEQADKPYSCPICQKPFKHLSELSRHER--IHTGE--KPYKCT--LCDKSFSQSSHLVHHKRTHSSERPYKC--AVC 263
Cdd:COG5048   280 SSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNS 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 264 EKTFKHRSHLVRH--MYAHSGEHH--LFRCNV--CELHFKESSELLQHPCT--PSGERPFRCGECQKAFKRPSDLRQHER 335
Cdd:COG5048   360 SSKFSPLLNNEPPqsLQQYKDLKNdkKSETLSnsCIRNFKRDSNLSLHIIThlSFRPYNCKNPPCSKSFNRHYNLIPHKK 439

                         170
                  ....*....|....
gi 1858900822 336 THSAERPFKCDLCP 349
Cdd:COG5048   440 IHTNHAPLLCSILK 453
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 425-505 5.28e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 52.41  E-value: 5.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 425 ERPFKCPV--CNKAYKRASALQKHQL-AHCAAAEKPlrctlcerrffsSSEFVQHRCDPAREKPLKCPDCEKRFKYASDL 501
Cdd:COG5189   347 GKPYKCPVegCNKKYKNQNGLKYHMLhGHQNQKLHE------------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL 414


                  ....
gi 1858900822 502 QRHR 505
Cdd:COG5189   415 KYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
500-525 5.01e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.01e-05
                          10        20
                  ....*....|....*....|....*.
gi 1858900822 500 DLQRHRRVHTGEKPYKCPNCDKAFKQ 525
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 366-446 1.77e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 366 KTEEPFKCGL--CEKGFGQPSHLLYHQ---HVHTLETLFKCPVCQKGFDqsaellrhkclpgAAERPFKCPVCNKAYKRA 440
Cdd:COG5189   345 KDGKPYKCPVegCNKKYKNQNGLKYHMlhgHQNQKLHENPSPEKMNIFS-------------AKDKPYRCEVCDKRYKNL 411


                  ....*.
gi 1858900822 441 SALQKH 446
Cdd:COG5189   412 NGLKYH 417
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-349 6.07e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 192 VTPAEQADKPYSCPICQKPFKHLSELSRHER--IHTGE--KPYKCT--LCDKSFSQSSHLVHHKRTHSSERPYKC--AVC 263
Cdd:COG5048   280 SSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNS 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 264 EKTFKHRSHLVRH--MYAHSGEHH--LFRCNV--CELHFKESSELLQHPCT--PSGERPFRCGECQKAFKRPSDLRQHER 335
Cdd:COG5048   360 SSKFSPLLNNEPPqsLQQYKDLKNdkKSETLSnsCIRNFKRDSNLSLHIIThlSFRPYNCKNPPCSKSFNRHYNLIPHKK 439

                         170
                  ....*....|....
gi 1858900822 336 THSAERPFKCDLCP 349
Cdd:COG5048   440 IHTNHAPLLCSILK 453
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 425-505 5.28e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 52.41  E-value: 5.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 425 ERPFKCPV--CNKAYKRASALQKHQL-AHCAAAEKPlrctlcerrffsSSEFVQHRCDPAREKPLKCPDCEKRFKYASDL 501
Cdd:COG5189   347 GKPYKCPVegCNKKYKNQNGLKYHMLhGHQNQKLHE------------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL 414


                  ....
gi 1858900822 502 QRHR 505
Cdd:COG5189   415 KYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
500-525 5.01e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.01e-05
                          10        20
                  ....*....|....*....|....*.
gi 1858900822 500 DLQRHRRVHTGEKPYKCPNCDKAFKQ 525
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
216-241 1.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 1858900822 216 ELSRHERIHTGEKPYKCTLCDKSFSQ 241
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 366-446 1.77e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 366 KTEEPFKCGL--CEKGFGQPSHLLYHQ---HVHTLETLFKCPVCQKGFDqsaellrhkclpgAAERPFKCPVCNKAYKRA 440
Cdd:COG5189   345 KDGKPYKCPVegCNKKYKNQNGLKYHMlhgHQNQKLHENPSPEKMNIFS-------------AKDKPYRCEVCDKRYKNL 411


                  ....*.
gi 1858900822 441 SALQKH 446
Cdd:COG5189   412 NGLKYH 417
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-349 6.07e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 192 VTPAEQADKPYSCPICQKPFKHLSELSRHER--IHTGE--KPYKCT--LCDKSFSQSSHLVHHKRTHSSERPYKC--AVC 263
Cdd:COG5048   280 SSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNS 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 264 EKTFKHRSHLVRH--MYAHSGEHH--LFRCNV--CELHFKESSELLQHPCT--PSGERPFRCGECQKAFKRPSDLRQHER 335
Cdd:COG5048   360 SSKFSPLLNNEPPqsLQQYKDLKNdkKSETLSnsCIRNFKRDSNLSLHIIThlSFRPYNCKNPPCSKSFNRHYNLIPHKK 439

                         170
                  ....*....|....
gi 1858900822 336 THSAERPFKCDLCP 349
Cdd:COG5048   440 IHTNHAPLLCSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-524 1.57e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 191 TVTPAEQADKPYSCPICQKPFKHLSELSRHERIHTGEKPYKCTL--CDKSFSQSSHLVHHKRTHSSE-----------RP 257
Cdd:COG5048    23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNpsdlnskslplSN 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 258 YKCAVCEKTFKH---------RSHLVRHMYA-----------HSGEHHLFRCNVCELHFKESSELLQ------------- 304
Cdd:COG5048   103 SKASSSSLSSSSsnsndnnllSSHSLPPSSRdpqlpdllsisNLRNNPLPGNNSSSVNTPQSNSLHPplpanslskdpss 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 305 ------HPCTPSGERPFRCGECQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKTEEPFKCGLCEK 378
Cdd:COG5048   183 nlslliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 379 GFGQPSHLLYHQHVHTLE-------TLFKCPVCQKGFDQSAELLRHKCL---PGAAERPFKCPV--CNKAYKRASALQKH 446
Cdd:COG5048   263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnhSGESLKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 447 QLAH---CAAAEKPLRCTLCERRFF--SSSEFVQHRCDPAREKPLKC--PDCEKRFKYASDLQRHRRVHTGEKPYKCPN- 518
Cdd:COG5048   343 ILLHtsiSPAKEKLLNSSSKFSPLLnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNp 422


                  ....*..
gi 1858900822 519 -CDKAFK 524
Cdd:COG5048   423 pCSKSFN 429
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 425-505 5.28e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 52.41  E-value: 5.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 425 ERPFKCPV--CNKAYKRASALQKHQL-AHCAAAEKPlrctlcerrffsSSEFVQHRCDPAREKPLKCPDCEKRFKYASDL 501
Cdd:COG5189   347 GKPYKCPVegCNKKYKNQNGLKYHMLhGHQNQKLHE------------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL 414


                  ....
gi 1858900822 502 QRHR 505
Cdd:COG5189   415 KYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
500-525 5.01e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.01e-05
                          10        20
                  ....*....|....*....|....*.
gi 1858900822 500 DLQRHRRVHTGEKPYKCPNCDKAFKQ 525
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-418 5.85e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 5.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 206 ICQKPFKHLSELSRHERIHTGEKP--YKCTLCDKSFSQSSHLVHHKRTHSSER-PYKCAVCEKTFKHRSHLVRHMYAHSg 282
Cdd:COG5048   235 LSPKSLLSQSPSSLSSSDSSSSASesPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSVN- 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 283 ehhlfrcnvcelhfKESSELLQHPCTPSGerpfrcgeCQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYAL---- 358
Cdd:COG5048   314 --------------HSGESLKPFSCPYSL--------CGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnep 371

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1858900822 359 ---MRHRRTHKTEEPFKC--GLCEKGFGQPSHLLYHQHVHTLET--LFKCPVCQKGFDQSAELLRHK 418
Cdd:COG5048   372 pqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRpyNCKNPPCSKSFNRHYNLIPHK 438
zf-H2C2_2 pfam13465
Zinc-finger double domain;
216-241 1.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 1858900822 216 ELSRHERIHTGEKPYKCTLCDKSFSQ 241
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-549 8.44e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 8.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 228 KPYKCTLCDKSFSQSSHLVHHKRTHSSERPYKCAV--CEKTFKHRSHLVRHMYAHSGEHhlfrcnvceLHFKESSELLQH 305
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNP---------SDLNSKSLPLSN 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 306 PCTPSGERPFrcgeCQKAFKRPSDLRQHERTHSAERPFKCDLCP---MGFKQQYALMRHRRTHKTEEPFK-----CGLCE 377
Cdd:COG5048   103 SKASSSSLSS----SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSisnLRNNPLPGNNSSSVNTPQSNSLHpplpaNSLSK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 378 KGFGQPSHLLYHQHVHTLETLFKCPVCQK----GFDQSAELLRHKclPGAAERPFKCPVCNKAYKRASALQKHQLAHCAA 453
Cdd:COG5048   179 DPSSNLSLLISSNVSTSIPSSSENSPLSSsysiPSSSSDQNLENS--SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 454 AEKPLRCTLCERRFFSSS----EFVQHRcdpAREKPLKCPDCEKRFKYASDLQRHRR--VHTGE--KPYKCP--NCDKAF 523
Cdd:COG5048   257 ASESPRSSLPTASSQSSSpnesDSSSEK---GFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLF 333

                         330       340
                  ....*....|....*....|....*.
gi 1858900822 524 KQREHLNKHQGVHAREQQFKCVWCGE 549
Cdd:COG5048   334 SRNDALKRHILLHTSISPAKEKLLNS 359
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 255-338 8.92e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 8.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 255 ERPYKCAV--CEKTFKHRSHLVRHMYahsgEHHlfrcnvCELHFKESSELLQHPCTPSGERPFRCGECQKAFKRPSDLRQ 332
Cdd:COG5189   347 GKPYKCPVegCNKKYKNQNGLKYHML----HGH------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1858900822 333 HeRTHS 338
Cdd:COG5189   417 H-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 366-446 1.77e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 366 KTEEPFKCGL--CEKGFGQPSHLLYHQ---HVHTLETLFKCPVCQKGFDqsaellrhkclpgAAERPFKCPVCNKAYKRA 440
Cdd:COG5189   345 KDGKPYKCPVegCNKKYKNQNGLKYHMlhgHQNQKLHENPSPEKMNIFS-------------AKDKPYRCEVCDKRYKNL 411


                  ....*.
gi 1858900822 441 SALQKH 446
Cdd:COG5189   412 NGLKYH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 226-272 4.29e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 4.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1858900822 226 GEKPYKCTL--CDKSFSQSSHLVHHKRT-HSSE------------------RPYKCAVCEKTFK-------HRSH 272
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQklhenpspekmnifsakdKPYRCEVCDKRYKnlnglkyHRKH 420
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
89-532 6.34e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 6.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822  89 SSPHEHQCLAGHDRSFQCTQCLKIFHQATDLLEHQCVQAEQKPFVCGV--CKMGFSLLTSLAQHHSSH--SGLVKCSICE 164
Cdd:COG5048    19 TPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHhnNPSDLNSKSL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 165 KTYKpaeaaepatTAAPSLPAAPAPSTVTPAEQADKPYSCPICQKPFKHLSELSRHERIHtgeKPYKCTLCDKSFSQSSH 244
Cdd:COG5048    99 PLSN---------SKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNN---PLPGNNSSSVNTPQSNS 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 245 LVH-HKRTHSSERPYKCAVCE----KTFKHRSHLVRHMYAHSGEhhlfrcnvcelhfKESSELLQHPCTPSGERPfrCGE 319
Cdd:COG5048   167 LHPpLPANSLSKDPSSNLSLLissnVSTSIPSSSENSPLSSSYS-------------IPSSSSDQNLENSSSSLP--LTT 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 320 CQKAFKRPSDLRQHERTHSAERPFKCDLCPMGFKQQYALMRHRRTHKTEE-------PFKCGLCEKGFGQPSHLLYHQ-- 390
Cdd:COG5048   232 NSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLrs 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1858900822 391 HVHTLETL--FKCPV--CQKGFDQSAELLRHKCLPGAAeRPFKCP--VCNKAYKRASA---LQKHQLAHCAAAEKPLRCT 461
Cdd:COG5048   312 VNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSI-SPAKEKllNSSSKFSPLLNnepPQSLQQYKDLKNDKKSETL 390

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1858900822 462 L------CERRFFSSSEFVQHRCDpaREKPLKCPDCEKRFKYASDLQRHRRVHTgEKPYKCPNCDKAFKQREHLNKH 532
Cdd:COG5048   391 SnscirnFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 230-252 8.04e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.04e-03
                          10        20
                  ....*....|....*....|...
gi 1858900822 230 YKCTLCDKSFSQSSHLVHHKRTH 252
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH