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Conserved domains on  [gi|1862366452|ref|NP_001371666|]
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microtubule-associated protein 4 isoform 32 [Homo sapiens]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 967-996 1.54e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 1.54e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862366452  967 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 996
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 998-1027 2.46e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.46e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862366452  998 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 1027
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1029-1059 4.87e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 4.87e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862366452 1029 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1059
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 906-927 2.59e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.49  E-value: 2.59e-08
                           10        20
                   ....*....|....*....|..
gi 1862366452  906 DLKNVRSKVGSTENIKHQPGGG 927
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 575-893 1.01e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  575 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 653
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  654 CNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASglvPAAPPKRPAV 733
Cdd:PHA03247  2669 RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPAL---PAAPAPPAVP 2745

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  734 ASArpsILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSgskSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIK 813
Cdd:PHA03247  2746 AGP---ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL---TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  814 TEGKPAEVKKMTAKSVPADLSRPKSTSTSSmkktTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP 893
Cdd:PHA03247  2820 PAASPAGPLPPPTSAQPTAPPPPPGPPPPS----LPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 967-996 1.54e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 1.54e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862366452  967 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 996
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 998-1027 2.46e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.46e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862366452  998 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 1027
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1029-1059 4.87e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 4.87e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862366452 1029 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1059
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 906-927 2.59e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.49  E-value: 2.59e-08
                           10        20
                   ....*....|....*....|..
gi 1862366452  906 DLKNVRSKVGSTENIKHQPGGG 927
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 575-893 1.01e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  575 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 653
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  654 CNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASglvPAAPPKRPAV 733
Cdd:PHA03247  2669 RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPAL---PAAPAPPAVP 2745

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  734 ASArpsILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSgskSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIK 813
Cdd:PHA03247  2746 AGP---ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL---TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  814 TEGKPAEVKKMTAKSVPADLSRPKSTSTSSmkktTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP 893
Cdd:PHA03247  2820 PAASPAGPLPPPTSAQPTAPPPPPGPPPPS----LPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 768-956 7.51e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 40.33  E-value: 7.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  768 SAPASRSGSKSTQTVAKTttaaavasTGPSSRSPSTLLPKKPTAIKteGKPAEVKKMTAKSVPadlsrpkSTSTSSMKKT 847
Cdd:pfam17823   98 SEPATREGAADGAASRAL--------AAAASSSPSSAAQSLPAAIA--ALPSEAFSAPRAAAC-------RANASAAPRA 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  848 TTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSA--KPSSTTPR--LSRLATNTSAPDLKNVRSKVGsteNIKHQ 923
Cdd:pfam17823  161 AIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAAssAPATLTPArgISTAATATGHPAAGTALAAVG---NSSPA 237

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1862366452  924 PGGGRAKVEKKTEAAATTRKPESNAVTKTAGPI 956
Cdd:pfam17823  238 AGTVTAAVGTVTPAALATLAAAAGTVASAAGTI 270
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 967-996 1.54e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 1.54e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862366452  967 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 996
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 998-1027 2.46e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.46e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862366452  998 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 1027
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1029-1059 4.87e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 4.87e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862366452 1029 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1059
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 906-927 2.59e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.49  E-value: 2.59e-08
                           10        20
                   ....*....|....*....|..
gi 1862366452  906 DLKNVRSKVGSTENIKHQPGGG 927
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 575-893 1.01e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  575 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 653
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  654 CNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASglvPAAPPKRPAV 733
Cdd:PHA03247  2669 RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPAL---PAAPAPPAVP 2745

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  734 ASArpsILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSgskSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIK 813
Cdd:PHA03247  2746 AGP---ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL---TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  814 TEGKPAEVKKMTAKSVPADLSRPKSTSTSSmkktTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP 893
Cdd:PHA03247  2820 PAASPAGPLPPPTSAQPTAPPPPPGPPPPS----LPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST 2895
PHA03247 PHA03247
large tegument protein UL36; Provisional
 653-963 1.66e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  653 PCNSQPSELSSETSGIARPEEGRPVVSG--TGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPmslASGLVPAAPPKR 730
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD---PHPPPTVPPPER 2651

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  731 PAVASARPSILPSKDVKPKpiadAKAPEKRASPSKPaSAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPT 810
Cdd:PHA03247  2652 PRDDPAPGRVSRPRRARRL----GRAAQASSPPQRP-RRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPA 2726

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  811 AIKTEGKPAevkkmtaksvPADLSRPKSTstssmkktttlsgTAPAAGVVPSRVKATPMPSRPSTTpfidkKPTSAKPSS 890
Cdd:PHA03247  2727 AARQASPAL----------PAAPAPPAVP-------------AGPATPGGPARPARPPTTAGPPAP-----APPAAPAAG 2778

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1862366452  891 TTPRLSRLATNTSAPDLKNVRSKVGSTENIkhQPGGGRAKVEKKTEAAATTRKPESnAVTKTAGPIASAQKQP 963
Cdd:PHA03247  2779 PPRRLTRPAVASLSESRESLPSPWDPADPP--AAVLAPAAALPPAASPAGPLPPPT-SAQPTAPPPPPGPPPP 2848
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 653-945 1.55e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.75  E-value: 1.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  653 PCNSQPSELSSETS-GIARPEEGRPVVSGTGNDITTPPNkelpPSPEKKtkpaPTTIGGLNKKPmslaSGLVPAAPPKRp 731
Cdd:PTZ00449   524 PGDKEGEEGEHEDSkESDEPKEGGKPGETKEGEVGKKPG----PAKEHK----PSKIPTLSKKP----EFPKDPKHPKD- 590

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  732 avasarpsilPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPsSRSPSTLLPKKPTA 811
Cdd:PTZ00449   591 ----------PEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSP-ERPEGPKIIKSPKP 659

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  812 IKTEGKP--AEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPM---PSRPSTTPFIDKKPtsA 886
Cdd:PTZ00449   660 PKSPKPPfdPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRplpPKLPRDEEFPFEPI--G 737

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  887 KPSSTTPRLSRLATntsAPDLKNVRSKvgstENIKHQPGGGRAKVEKKTE-AAATTRKPE 945
Cdd:PTZ00449   738 DPDAEQPDDIEFFT---PPEEERTFFH----ETPADTPLPDILAEEFKEEdIHAETGEPD 790
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 727-888 1.60e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.75  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  727 PPKRPAvASARPsilpskdvkPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPS-----SRSP 801
Cdd:PTZ00449   510 PPEGPE-ASGLP---------PKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSkiptlSKKP 579

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  802 StlLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTL--SGTAPAAGVVPSRVKAtpmPSRPSTT--P 877
Cdd:PTZ00449   580 E--FPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRpeSPKSPKRPPPPQRPSS---PERPEGPkiI 654

                          170
                   ....*....|.
gi 1862366452  878 FIDKKPTSAKP 888
Cdd:PTZ00449   655 KSPKPPKSPKP 665
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 652-774 3.36e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 3.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  652 KPCNSQPSELSSETSGIARPEEGRPVVSgtgndittppnkelpPSPEKKTKPAPTTIGGLNKKPMslASGLVPAAPPKRP 731
Cdd:PRK14951   365 KPAAAAEAAAPAEKKTPARPEAAAPAAA---------------PVAQAAAAPAPAAAPAAAASAP--AAPPAAAPPAPVA 427

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1862366452  732 AVASARPSILPSKDVKPKPIADA----KAPEKRASPSKPASAPASRS 774
Cdd:PRK14951   428 APAAAAPAAAPAAAPAAVALAPAppaqAAPETVAIPVRVAPEPAVAS 474
PHA03247 PHA03247
large tegument protein UL36; Provisional
 665-901 4.55e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 4.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  665 TSGIARPEEGRPVVSGTGNDITTPPNKEL---------PPSPEKKTKPAPTTIGGLNKK-----PMSLASGLVPAAPPKR 730
Cdd:PHA03247  2763 TAGPPAPAPPAAPAAGPPRRLTRPAVASLsesreslpsPWDPADPPAAVLAPAAALPPAaspagPLPPPTSAQPTAPPPP 2842

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  731 PA-VASARP---SILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLP 806
Cdd:PHA03247  2843 PGpPPPSLPlggSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQ 2922

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  807 KKPTAIKTegkPAEVKKMTAKSVPADLSRPKSTSTSS-MKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPfidkkPTS 885
Cdd:PHA03247  2923 PPPPPQPQ---PPPPPPPRPQPPLAPTTDPAGAGEPSgAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS-----STP 2994

                          250
                   ....*....|....*.
gi 1862366452  886 AKPSSTTPRLSRLATN 901
Cdd:PHA03247  2995 PLTGHSLSRVSSWASS 3010
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 653-897 4.67e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 4.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  653 PCNSQPSELSSETSGIARPEEGRP--VVSGTGNDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASGLVPAAPPKR 730
Cdd:PHA03307   148 PAASPPAAGASPAAVASDAASSRQaaLPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRS 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  731 PAV--ASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAaavaSTGPSSRSPSTLlPKK 808
Cdd:PHA03307   228 AADdaGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASS----SSSPRERSPSPS-PSS 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  809 PTAIKTEGKPAEVKKMTAKSvPADLSRPKSTSTSSMKKTTTlSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKP 888
Cdd:PHA03307   303 PGSGPAPSSPRASSSSSSSR-ESSSSSTSSSSESSRGAAVS-PGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAA 380


                   ....*....
gi 1862366452  889 SSTTPRLSR 897
Cdd:PHA03307   381 SAGRPTRRR 389
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
703-964 5.21e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.99  E-value: 5.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  703 PAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASAR-------PSILPSKDVKPKPIADA-----KAPEKRASPskPASAP 770
Cdd:PRK07003   360 PAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASavpavtaVTGAAGAALAPKAAAAAaatraEAPPAAPAP--PATAD 437

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  771 ASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKmtAKSVPADLSRPKSTSTSSmkktttl 850
Cdd:PRK07003   438 RGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAF--EPAPRAAAPSAATPAAVP------- 508

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  851 sgtAPAAGVVPSRVKATPMPSRPSttpfidkkPTSAKPSSTTPRLSRLATNTSAP--DLKNVRSKVGSTeniKHQPGGGR 928
Cdd:PRK07003   509 ---DARAPAAASREDAPAAAAPPA--------PEARPPTPAAAAPAARAGGAAAAldVLRNAGMRVSSD---RGARAAAA 574

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1862366452  929 AKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPA 964
Cdd:PRK07003   575 AKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPP 610
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 768-956 7.51e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 40.33  E-value: 7.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  768 SAPASRSGSKSTQTVAKTttaaavasTGPSSRSPSTLLPKKPTAIKteGKPAEVKKMTAKSVPadlsrpkSTSTSSMKKT 847
Cdd:pfam17823   98 SEPATREGAADGAASRAL--------AAAASSSPSSAAQSLPAAIA--ALPSEAFSAPRAAAC-------RANASAAPRA 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862366452  848 TTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSA--KPSSTTPR--LSRLATNTSAPDLKNVRSKVGsteNIKHQ 923
Cdd:pfam17823  161 AIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAAssAPATLTPArgISTAATATGHPAAGTALAAVG---NSSPA 237

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1862366452  924 PGGGRAKVEKKTEAAATTRKPESNAVTKTAGPI 956
Cdd:pfam17823  238 AGTVTAAVGTVTPAALATLAAAAGTVASAAGTI 270
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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