NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1862756478|ref|NP_001371782|]
View 

microtubule-associated protein 4 isoform 85 [Homo sapiens]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
898-927 1.42e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.42e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862756478  898 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 927
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
929-958 2.27e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.27e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862756478  929 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 958
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
534-878 2.77e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.43  E-value: 2.77e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  534 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 612
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  613 CNSQPSELSSETSGiARPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTI 692
Cdd:PHA03247  2669 RLGRAAQASSPPQR-PRRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  693 GGLNKKPMSLASGLVPAAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTT 770
Cdd:PHA03247  2745 PAGPATPGGPARPARPPTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  771 TAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVV 844
Cdd:PHA03247  2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQ 2904
                          330       340       350
                   ....*....|....*....|....*....|....
gi 1862756478  845 PSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPR 878
Cdd:PHA03247  2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
960-990 4.58e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 4.58e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862756478  960 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 990
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
898-927 1.42e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.42e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862756478  898 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 927
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
929-958 2.27e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.27e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862756478  929 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 958
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
534-878 2.77e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.43  E-value: 2.77e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  534 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 612
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  613 CNSQPSELSSETSGiARPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTI 692
Cdd:PHA03247  2669 RLGRAAQASSPPQR-PRRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  693 GGLNKKPMSLASGLVPAAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTT 770
Cdd:PHA03247  2745 PAGPATPGGPARPARPPTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  771 TAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVV 844
Cdd:PHA03247  2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQ 2904
                          330       340       350
                   ....*....|....*....|....*....|....
gi 1862756478  845 PSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPR 878
Cdd:PHA03247  2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
960-990 4.58e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 4.58e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862756478  960 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 990
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
537-889 1.41e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.06  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  537 PLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTF----MISPE---TVTGTGKKCSLPAEEDSVLEklge 609
Cdd:pfam05109  425 PESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVstadVTSPTpagTTSGASPVTPSPSPRDNGTE---- 500
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  610 rkpcnSQPSELSSETSGIARPEegrPVVSGTGNDITTP-PNKELP-------------PSPEKKTKPLATTQPAKTST-- 673
Cdd:pfam05109  501 -----SKAPDMTSPTSAVTTPT---PNATSPTPAVTTPtPNATSPtlgktsptsavttPTPNATSPTPAVTTPTPNATip 572
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  674 SKAKTQPTSLPKQPAPT------------------TIGGLNKKPmslasglVPAAPPKRP--AVASARPSILPSK----D 729
Cdd:pfam05109  573 TLGKTSPTSAVTTPTPNatsptvgetspqanttnhTLGGTSSTP-------VVTSPPKNAtsAVTTGQHNITSSStssmS 645
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  730 VKPKPIADAKAPEK--RASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTG-PSSRSPSTLLPKKPTAIKTEGKPAEV- 805
Cdd:pfam05109  646 LRPSSISETLSPSTsdNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSsPAPRPGTTSQASGPGNSSTSTKPGEVn 725
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  806 -------KKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVvPSRVKATPMPSR--PSTTPFIDKKPTSAKPSSTT 876
Cdd:pfam05109  726 vtkgtppKNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGH-GARTSTEPTTDYggDSTTPRTRYNATTYLPPSTS 804
                          410
                   ....*....|...
gi 1862756478  877 PRLSRLATNTSAP 889
Cdd:pfam05109  805 SKLRPRWTFTSPP 817
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
898-927 1.42e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.51  E-value: 1.42e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862756478  898 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 927
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
929-958 2.27e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.27e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1862756478  929 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 958
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
534-878 2.77e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.43  E-value: 2.77e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  534 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 612
Cdd:PHA03247  2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  613 CNSQPSELSSETSGiARPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTI 692
Cdd:PHA03247  2669 RLGRAAQASSPPQR-PRRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  693 GGLNKKPMSLASGLVPAAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTT 770
Cdd:PHA03247  2745 PAGPATPGGPARPARPPTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  771 TAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVV 844
Cdd:PHA03247  2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQ 2904
                          330       340       350
                   ....*....|....*....|....*....|....
gi 1862756478  845 PSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPR 878
Cdd:PHA03247  2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
PHA03247 PHA03247
large tegument protein UL36; Provisional
612-889 3.09e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 3.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  612 PCNSQPSELSSETSGIARPEEGRPVVSG--TGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAP 689
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRD 2654
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  690 TTIGG---LNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDvkpkpIADAKAPEKRASPSKPASAPASRSGSKSTQTV 766
Cdd:PHA03247  2655 DPAPGrvsRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS-----LADPPPPPPTPEPAPHALVSATPLPPGPAAAR 2729
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  767 AKTTTAAAVASTGPSSRSPSTllPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTstssmkktttlsgtAPAAGVVPS 846
Cdd:PHA03247  2730 QASPALPAAPAPPAVPAGPAT--PGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT--------------RPAVASLSE 2793
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1862756478  847 RVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAP 889
Cdd:PHA03247  2794 SRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
960-990 4.58e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 4.58e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1862756478  960 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 990
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
627-884 7.77e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 7.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  627 IARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTS----LPKQPAPTTIGGLNKKPmSL 702
Cdd:PHA03247  2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESReslpSPWDPADPPAAVLAPAA-AL 2818
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  703 ASGLVPAAP-PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPS 781
Cdd:PHA03247  2819 PPAASPAGPlPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF 2898
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  782 SRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADlsRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTP 861
Cdd:PHA03247  2899 ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP--PPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR 2976
                          250       260
                   ....*....|....*....|....*
gi 1862756478  862 FI--DKKPTSAKPSSTTPRLSRLAT 884
Cdd:PHA03247  2977 FRvpQPAPSREAPASSTPPLTGHSL 3001
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
532-889 2.05e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.10  E-value: 2.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  532 AKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERK 611
Cdd:PHA03307    15 AEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLST 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  612 PCNSQPSELSSETSGIARPEEGRPvvsgtgndiTTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTt 691
Cdd:PHA03307    95 LAPASPAREGSPTPPGPSSPDPPP---------PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVAS- 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  692 iGGLNKKPMSLASGLVPAA-----PPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTV 766
Cdd:PHA03307   165 -DAASSRQAALPLSSPEETarapsSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSE 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  767 AKTTTAAAVASTGPSSRSPSTLLPKKPTAIktEGKPAEVKKMTAKSVPADLSR-----------PKSTSTSSMKKTTTLS 835
Cdd:PHA03307   244 SSGCGWGPENECPLPRPAPITLPTRIWEAS--GWNGPSSRPGPASSSSSPRERspspspsspgsGPAPSSPRASSSSSSS 321
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1862756478  836 GTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAP 889
Cdd:PHA03307   322 RESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAP 375
PHA03247 PHA03247
large tegument protein UL36; Provisional
619-896 1.87e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 1.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  619 ELSSETSGIARPEEGrPVVSGTGNDITTPPNKELPPSPE-----KKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPttig 693
Cdd:PHA03247  2542 ELASDDAGDPPPPLP-PAAPPAAPDRSVPPPRPAPRPSEpavtsRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---- 2616
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  694 glnkkpmslasgLVPAAPPKRPAVASARPSilPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAA 773
Cdd:PHA03247  2617 ------------LPPDTHAPDPPPPSPSPA--ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR 2682
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  774 AVASTGPSSRSPSTLLPKKPTAIKTegkPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVkaTPM 853
Cdd:PHA03247  2683 PRRRAARPTVGSLTSLADPPPPPPT---PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGP--ARP 2757
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1862756478  854 PSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRS 896
Cdd:PHA03247  2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
686-877 9.23e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.77  E-value: 9.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  686 QPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASAR-------PSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRS 758
Cdd:PRK07003   359 EPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASavpavtaVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADR 438
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  759 GSKSTQtvaktttaaavastgpssrSPSTLLPKKPTAIKTEGKPAEvkkmtAKSVPADLSRPKSTSTSSMKKTTTLSGTA 838
Cdd:PRK07003   439 GDDAAD-------------------GDAPVPAKANARASADSRCDE-----RDAQPPADSGSASAPASDAPPDAAFEPAP 494
                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1862756478  839 PAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP 877
Cdd:PRK07003   495 RAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEAR 533
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
537-889 1.41e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.06  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  537 PLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTF----MISPE---TVTGTGKKCSLPAEEDSVLEklge 609
Cdd:pfam05109  425 PESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVstadVTSPTpagTTSGASPVTPSPSPRDNGTE---- 500
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  610 rkpcnSQPSELSSETSGIARPEegrPVVSGTGNDITTP-PNKELP-------------PSPEKKTKPLATTQPAKTST-- 673
Cdd:pfam05109  501 -----SKAPDMTSPTSAVTTPT---PNATSPTPAVTTPtPNATSPtlgktsptsavttPTPNATSPTPAVTTPTPNATip 572
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  674 SKAKTQPTSLPKQPAPT------------------TIGGLNKKPmslasglVPAAPPKRP--AVASARPSILPSK----D 729
Cdd:pfam05109  573 TLGKTSPTSAVTTPTPNatsptvgetspqanttnhTLGGTSSTP-------VVTSPPKNAtsAVTTGQHNITSSStssmS 645
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  730 VKPKPIADAKAPEK--RASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTG-PSSRSPSTLLPKKPTAIKTEGKPAEV- 805
Cdd:pfam05109  646 LRPSSISETLSPSTsdNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSsPAPRPGTTSQASGPGNSSTSTKPGEVn 725
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  806 -------KKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVvPSRVKATPMPSR--PSTTPFIDKKPTSAKPSSTT 876
Cdd:pfam05109  726 vtkgtppKNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGH-GARTSTEPTTDYggDSTTPRTRYNATTYLPPSTS 804
                          410
                   ....*....|...
gi 1862756478  877 PRLSRLATNTSAP 889
Cdd:pfam05109  805 SKLRPRWTFTSPP 817
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
617-881 1.45e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.93  E-value: 1.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  617 PSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTK--------PLATTQPAKTSTSKAKTQPTSLPKQPA 688
Cdd:PHA03307   122 PPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAassrqaalPLSSPEETARAPSSPPAEPPPSTPPAA 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  689 PTTIGGLNKKPMSLASGLVPAAPPKRPAV--ASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTV 766
Cdd:PHA03307   202 ASPRPPRRSSPISASASSPAPAPGRSAADdaGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSR 281
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  767 AKTTTAaavaSTGPSSRSPSTLlPKKPTAIKTEGKPAEVKKMTAKSvPADLSRPKSTSTSSMKKTTTlSGTAPAAGVVPS 846
Cdd:PHA03307   282 PGPASS----SSSPRERSPSPS-PSSPGSGPAPSSPRASSSSSSSR-ESSSSSTSSSSESSRGAAVS-PGPSPSRSPSPS 354
                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1862756478  847 RVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSR 881
Cdd:PHA03307   355 RPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRR 389
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
624-889 7.40e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 7.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  624 TSGIARPEEGRPVVSGT--GNDITTPPNKELPPSPEKKTKPLATTQPA--KTSTSKAKTQPTSLPKQPAPTTIGGLNKKP 699
Cdd:PRK07003   363 TGGGAPGGGVPARVAGAvpAPGARAAAAVGASAVPAVTAVTGAAGAALapKAAAAAAATRAEAPPAAPAPPATADRGDDA 442
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  700 MSlasglVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTG 779
Cdd:PRK07003   443 AD-----GDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAS 517
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  780 PSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPST 859
Cdd:PRK07003   518 REDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALDVLRNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVP 597
                          250       260       270
                   ....*....|....*....|....*....|
gi 1862756478  860 TPFIDKKPTSAKPSSTTPRLSRLATNTSAP 889
Cdd:PRK07003   598 TPRARAATGDAPPNGAARAEQAAESRGAPP 627
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
711-872 2.27e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.98  E-value: 2.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  711 PPKRPAvASARPsilpskdvkPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPS-----SRSP 785
Cdd:PTZ00449   510 PPEGPE-ASGLP---------PKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSkiptlSKKP 579
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  786 StlLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTL--SGTAPAAGVVPSRVKAtpmPSRPSTT--P 861
Cdd:PTZ00449   580 E--FPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRpeSPKSPKRPPPPQRPSS---PERPEGPkiI 654
                          170
                   ....*....|.
gi 1862756478  862 FIDKKPTSAKP 872
Cdd:PTZ00449   655 KSPKPPKSPKP 665
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
612-887 2.71e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.98  E-value: 2.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  612 PCNSQPSELSSETS-GIARPEEGRPVVSGTGNDITTPPNkelPPSPEKKTK-PLATTQPAKTSTSKAKTQPTS--LPKQP 687
Cdd:PTZ00449   524 PGDKEGEEGEHEDSkESDEPKEGGKPGETKEGEVGKKPG---PAKEHKPSKiPTLSKKPEFPKDPKHPKDPEEpkKPKRP 600
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  688 APTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPA---------------S 752
Cdd:PTZ00449   601 RSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKppfdpkfkekfyddyL 680
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  753 APASRSGSKSTQTVAKTTTAAAVASTGPSS-----RSPSTLLPKKPTAIKTEGKPaeVKKMTAKSV-PADLSRPKSTSTS 826
Cdd:PTZ00449   681 DAAAKSKETKTTVVLDESFESILKETLPETpgtpfTTPRPLPPKLPRDEEFPFEP--IGDPDAEQPdDIEFFTPPEEERT 758
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1862756478  827 SMKKTttlSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP------------RLSRLATNTS 887
Cdd:PTZ00449   759 FFHET---PADTPLPDILAEEFKEEDIHAETGEPDEAMKRPDSPSEHEDKPpgdhpslpkkrhRLDGLALSTT 828
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
752-1042 2.78e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.83  E-value: 2.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  752 SAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTllpkkptaiKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKT 831
Cdd:pfam05109  459 TAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSP---------RDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTT 529
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  832 TTLSGTAPAAG-VVPSRVKATPMPSRPSTTPFIdkkpTSAKPSSTTPRLSRLATNtsapdlknvrSKVQIVSKKVSYSHI 910
Cdd:pfam05109  530 PTPNATSPTLGkTSPTSAVTTPTPNATSPTPAV----TTPTPNATIPTLGKTSPT----------SAVTTPTPNATSPTV 595
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  911 QSKCGSKDNIKHVPGGgnvqIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGG 990
Cdd:pfam05109  596 GETSPQANTTNHTLGG----TSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLT 671
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1862756478  991 AVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGD 1042
Cdd:pfam05109  672 SAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGE 723
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
597-889 4.46e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 4.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  597 PAEEDSVLEKLGERKPCNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKT-----KPLATTQPAKT 671
Cdd:pfam03154  151 PQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATsqppnQTQSTAAPHTL 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  672 STSKAKTQPTSLPK-----QPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKdVKPKPIADAKAPEKRAS 746
Cdd:pfam03154  231 IQQTPTLHPQRLPSphpplQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHP-VPPQPFPLTPQSSQSQV 309
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  747 PSKPASA-----------PASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAiKTEGKPAEVKKMTAKSVPA 815
Cdd:pfam03154  310 PPGPSPAapgqsqqrihtPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNP-QSHKHPPHLSGPSPFQMNS 388
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1862756478  816 DLSRPKSTST-SSMKKTTTLSGTAPAAGVVPsrvKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAP 889
Cdd:pfam03154  389 NLPPPPALKPlSSLSTHHPPSAHPPPLQLMP---QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQS 460
PHA03247 PHA03247
large tegument protein UL36; Provisional
516-854 4.71e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 4.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  516 PLAKDGVLTLANNVTPAkdvPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKkcs 595
Cdd:PHA03247  2686 RAARPTVGSLTSLADPP---PPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR--- 2759
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  596 lPAEEDSVLEKLGERKPCNSQPSELS---SETSGIARPEEGRPVVSGTGNDITTPPNKELPPS--PEKKTKPLATTQPAK 670
Cdd:PHA03247  2760 -PPTTAGPPAPAPPAAPAAGPPRRLTrpaVASLSESRESLPSPWDPADPPAAVLAPAAALPPAasPAGPLPPPTSAQPTA 2838
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  671 TSTSKAKTQPtSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDV------------KPKPIADA 738
Cdd:PHA03247  2839 PPPPPGPPPP-SLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESfalppdqperppQPQAPPPP 2917
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  739 KAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPkkptaikteGKPAEVKKMTAKSVPadlS 818
Cdd:PHA03247  2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP---------GRVAVPRFRVPQPAP---S 2985
                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1862756478  819 RPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMP 854
Cdd:PHA03247  2986 REAPASSTPPLTGHSLSRVSSWASSLALHEETDPPP 3021
PHA03378 PHA03378
EBNA-3B; Provisional
631-877 6.32e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 6.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  631 EEGRPVVSGTGNDITTPPNK----ELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGL 706
Cdd:PHA03378   549 ESDEPASTEPVHDQLLPAPGlgplQIQPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPL 628
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  707 VP-AAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASapasrsgskstqtvaktttaaavastgPSSRSP 785
Cdd:PHA03378   629 RPiPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQ---------------------------PSPTGA 681
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  786 STLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVK---ATPMPSRPSTTPF 862
Cdd:PHA03378   682 NTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARppaAAPGRARPPAAAP 761
                          250
                   ....*....|....*
gi 1862756478  863 IDKKPTSAKPSSTTP 877
Cdd:PHA03378   762 GRARPPAAAPGAPTP 776
PHA03247 PHA03247
large tegument protein UL36; Provisional
406-760 7.95e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 7.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  406 ARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPET 485
Cdd:PHA03247  2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  486 EVVLIKNVCLP-----PEMEVALTEDQVPALKTEAPLAKDGVLTLANNvTPAKDVPPLSETEATPVPIKDMEIAQTQKGI 560
Cdd:PHA03247  2747 GPATPGGPARParpptTAGPPAPAPPAAPAAGPPRRLTRPAVASLSES-RESLPSPWDPADPPAAVLAPAAALPPAASPA 2825
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  561 SEDSHLESLQDVGQSAAPTFMISPETVTGTgkkcSLPAEEdsvlekLGERKPCNSQPSELSSETSGIARpEEGRPVVSGT 640
Cdd:PHA03247  2826 GPLPPPTSAQPTAPPPPPGPPPPSLPLGGS----VAPGGD------VRRRPPSRSPAAKPAAPARPPVR-RLARPAVSRS 2894
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862756478  641 GNDITTPPNK-ELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGglnKKPMSLASGLVPAapPKRPAVAS 719
Cdd:PHA03247  2895 TESFALPPDQpERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD---PAGAGEPSGAVPQ--PWLGALVP 2969
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1862756478  720 ARPSILPSKDVKPKPIADAKAPekraSPSKPASAPASRSGS 760
Cdd:PHA03247  2970 GRVAVPRFRVPQPAPSREAPAS----STPPLTGHSLSRVSS 3006
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH