|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-95 |
6.18e-53 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
:
Pssm-ID: 436519 Cd Length: 95 Bit Score: 180.22 E-value: 6.18e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1864245115 81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
222-383 |
4.05e-46 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 163.63 E-value: 4.05e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159
|
....*..
gi 1864245115 377 NHFFSAQ 383
Cdd:pfam05729 160 RKYFSDE 166
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1527-1822 |
2.62e-36 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 144.16 E-value: 2.62e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1527 DLSHLLLNSSTLALLTHRLsqmtclQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE 1606
Cdd:COG5238 164 RLGLLAAISMAKALQNNSV------ETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1607 LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL--PQHLRVLHLPFSHLGPGGALSLAQALD 1684
Cdd:COG5238 238 LTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVNRIGDEGAIALAEGLQ 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1685 GSPHLEEISLAennlaggvlrfcmelpllrqidlvSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLP 1764
Cdd:COG5238 318 GNKTLHTLNLA------------------------YNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864245115 1765 QMGRLKRVDLEKNQITALGAWLLAEGLaQGSSIQVIRLWNNPIPCDMAQHLKSQEPRL 1822
Cdd:COG5238 374 GNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
173-530 |
1.22e-22 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
:
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 106.04 E-value: 1.22e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635 131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635 211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635 284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635 362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864245115 480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635 436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1413-1638 |
2.09e-20 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 94.34 E-value: 2.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1413 LAHCDLGAHHS-------LLVGQLMETCARLQQLSLSQVNLCEDddasSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHL 1485
Cdd:cd00116 53 LKELCLSLNETgriprglQSLLQGLTKGCGLQELDLSDNALGPD----GCGVLESLLRSSSLQELKLNNNGLGDRGLRLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1486 ASGLGHCHH-----------------------------LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1536
Cdd:cd00116 129 AKGLKDLPPaleklvlgrnrlegascealakalranrdLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1537 TLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRA-ATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGN 1615
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250 260
....*....|....*....|....
gi 1864245115 1616 SISSAGGVQLAESLV-LCRRLEEL 1638
Cdd:cd00116 289 KFGEEGAQLLAESLLePGNELESL 312
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
751-1069 |
5.59e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 82.53 E-value: 5.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238 69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238 147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238 221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245115 991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238 281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
|
|
| NLRC4_HD2 super family |
cl39284 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
514-628 |
7.71e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
The actual alignment was detected with superfamily member pfam17776:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 55.38 E-value: 7.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRW------VQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKREslksllDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1864245115 587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776 80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
|
|
| LRR super family |
cl34836 |
Leucine-rich repeat (LRR) protein [Transcription]; |
649-782 |
2.50e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
The actual alignment was detected with superfamily member COG4886:
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 45.69 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886 153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1864245115 729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1009-1336 |
4.36e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 44.65 E-value: 4.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1009 LDFSGNALGDEGAArlaQLLPGLGALQSLNLSENGLSLDAVLGLVRcfstlqwlfRLDISFESQHILLRGDKTSRDMWAT 1088
Cdd:cd00116 3 LSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLSLNETGRIPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1089 GSLPD-------------------FPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLE-LQLSCEFLS 1148
Cdd:cd00116 71 QSLLQgltkgcglqeldlsdnalgPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEkLVLGRNRLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1149 DQSLETLldclpqlpqlsllqlsqtglspkspfllANTLSLCPRVKKVDLR--SLHHATLH-----FRSNEEEEGVccGL 1221
Cdd:cd00116 151 GASCEAL----------------------------AKALRANRDLKELNLAnnGIGDAGIRalaegLKANCNLEVL--DL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1222 SANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPScprvreasvnlgseqsfrihfsrEDQAGKTLRL 1301
Cdd:cd00116 201 NNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLS-----------------------PNISLLTLSL 257
|
330 340 350
....*....|....*....|....*....|....*
gi 1864245115 1302 SECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQ 1336
Cdd:cd00116 258 SCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGE 292
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-95 |
6.18e-53 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 180.22 E-value: 6.18e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1864245115 81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
222-383 |
4.05e-46 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 163.63 E-value: 4.05e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159
|
....*..
gi 1864245115 377 NHFFSAQ 383
Cdd:pfam05729 160 RKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1527-1822 |
2.62e-36 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 144.16 E-value: 2.62e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1527 DLSHLLLNSSTLALLTHRLsqmtclQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE 1606
Cdd:COG5238 164 RLGLLAAISMAKALQNNSV------ETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1607 LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL--PQHLRVLHLPFSHLGPGGALSLAQALD 1684
Cdd:COG5238 238 LTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVNRIGDEGAIALAEGLQ 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1685 GSPHLEEISLAennlaggvlrfcmelpllrqidlvSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLP 1764
Cdd:COG5238 318 GNKTLHTLNLA------------------------YNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864245115 1765 QMGRLKRVDLEKNQITALGAWLLAEGLaQGSSIQVIRLWNNPIPCDMAQHLKSQEPRL 1822
Cdd:COG5238 374 GNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1493-1793 |
1.15e-32 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 130.17 E-value: 1.15e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1493 HHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSST--LALLTHRLSQMTCLQSLRLNRNSIGDVGCcHLS 1570
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLSDNALGPDGC-GVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1571 EALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE-LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPT 1649
Cdd:cd00116 102 ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1650 ALGLAQELP--QHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAggvlrfcmelpllrqidlvsckiDNQT 1727
Cdd:cd00116 182 IRALAEGLKanCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLT-----------------------DAGA 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245115 1728 AKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQ 1793
Cdd:cd00116 239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLE 304
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
173-530 |
1.22e-22 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 106.04 E-value: 1.22e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635 131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635 211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635 284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635 362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864245115 480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635 436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1413-1638 |
2.09e-20 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 94.34 E-value: 2.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1413 LAHCDLGAHHS-------LLVGQLMETCARLQQLSLSQVNLCEDddasSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHL 1485
Cdd:cd00116 53 LKELCLSLNETgriprglQSLLQGLTKGCGLQELDLSDNALGPD----GCGVLESLLRSSSLQELKLNNNGLGDRGLRLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1486 ASGLGHCHH-----------------------------LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1536
Cdd:cd00116 129 AKGLKDLPPaleklvlgrnrlegascealakalranrdLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1537 TLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRA-ATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGN 1615
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250 260
....*....|....*....|....
gi 1864245115 1616 SISSAGGVQLAESLV-LCRRLEEL 1638
Cdd:cd00116 289 KFGEEGAQLLAESLLePGNELESL 312
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1270-1658 |
2.89e-17 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 86.77 E-value: 2.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1270 PRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILlslvgrp 1349
Cdd:COG5238 156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEIL------- 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1350 aglfslrvqepwadrARVLSllevcaqasgsvteisisetqqqlcvqlefprqeENPeavalrlahcdlgahhsllvgql 1429
Cdd:COG5238 229 ---------------AEALK----------------------------------GNK----------------------- 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1430 metcaRLQQLSLSQVnlcedddasslllqslllslselktfrltssCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEG 1509
Cdd:COG5238 237 -----SLTTLDLSNN-------------------------------QIGDEGVIALAEALKNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1510 TKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQI 1589
Cdd:COG5238 281 AIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQI 360
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245115 1590 GDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLcRRLEELMLGCNALGDPTALGLAQELP 1658
Cdd:COG5238 361 GDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
751-1069 |
5.59e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 82.53 E-value: 5.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238 69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238 147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238 221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245115 991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238 281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
690-1069 |
9.65e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 68.15 E-value: 9.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 690 NLSFKSRKCGDAFAEALSRSLPTMgrlQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQL--SDQVVLNIVEVLP 767
Cdd:cd00116 2 QLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 768 HLPRLRKLDLSSNSICvstllclarvAVTCPTVrmlqareadlifllspptettAELQRAPDLQEsdgqrkgaqsrsltL 847
Cdd:cd00116 79 KGCGLQELDLSDNALG----------PDGCGVL---------------------ESLLRSSSLQE--------------L 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 848 RLQKCQLQVhDAEALIA--LLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAvsac 925
Cdd:cd00116 114 KLNNNGLGD-RGLRLLAkgLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEG---- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 926 wtlaelhislqhktvifmfaqepeeqkgpqeraafldslmLQMPSELplssRRMRLTHCGLQEKHLEQLCKALGGSCHLg 1005
Cdd:cd00116 189 ----------------------------------------LKANCNL----EVLDLNNNGLTDEGASALAETLASLKSL- 223
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1864245115 1006 hLHLDFSGNALGDEGAARLA-QLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:cd00116 224 -EVLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRG 287
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
514-628 |
7.71e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 55.38 E-value: 7.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRW------VQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKREslksllDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1864245115 587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776 80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
649-782 |
2.50e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 45.69 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886 153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1864245115 729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1551-1617 |
2.53e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 2.53e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245115 1551 LQSLRLNRNSIGDVGcchlSEALRAATSLEELDLSHNQIGdagvqhlaTILP----GLPELRKIDLSGNSI 1617
Cdd:pfam13855 3 LRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLLT--------TLSPgafsGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1009-1336 |
4.36e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 44.65 E-value: 4.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1009 LDFSGNALGDEGAArlaQLLPGLGALQSLNLSENGLSLDAVLGLVRcfstlqwlfRLDISFESQHILLRGDKTSRDMWAT 1088
Cdd:cd00116 3 LSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLSLNETGRIPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1089 GSLPD-------------------FPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLE-LQLSCEFLS 1148
Cdd:cd00116 71 QSLLQgltkgcglqeldlsdnalgPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEkLVLGRNRLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1149 DQSLETLldclpqlpqlsllqlsqtglspkspfllANTLSLCPRVKKVDLR--SLHHATLH-----FRSNEEEEGVccGL 1221
Cdd:cd00116 151 GASCEAL----------------------------AKALRANRDLKELNLAnnGIGDAGIRalaegLKANCNLEVL--DL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1222 SANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPScprvreasvnlgseqsfrihfsrEDQAGKTLRL 1301
Cdd:cd00116 201 NNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLS-----------------------PNISLLTLSL 257
|
330 340 350
....*....|....*....|....*....|....*
gi 1864245115 1302 SECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQ 1336
Cdd:cd00116 258 SCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGE 292
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
1519-1618 |
1.37e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 43.65 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1519 GKWMLKRLDLShlllNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVgcchLSEALRAATSLEELDLSHNQIGDAgvqhLA 1598
Cdd:PLN03150 416 GKWFIDGLGLD----NQGLRGFIPNDISKLRHLQSINLSGNSIRGN----IPPSLGSITSLEVLDLSYNSFNGS----IP 483
|
90 100
....*....|....*....|
gi 1864245115 1599 TILPGLPELRKIDLSGNSIS 1618
Cdd:PLN03150 484 ESLGQLTSLRILNLNGNSLS 503
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1577-1598 |
6.16e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 35.85 E-value: 6.16e-03
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
705-783 |
7.51e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 39.77 E-value: 7.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 705 ALSRSLptmgrlQMLGLAGSKITA-RGISHLVkalplcpQLKEVSFRDNQLSDqvVLNIVEVLPHLPRLRKLDLSSNSIC 783
Cdd:cd21340 117 ALSNSL------RVLNISGNNIDSlEPLAPLR-------NLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVC 181
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-95 |
6.18e-53 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 180.22 E-value: 6.18e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1864245115 81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
222-383 |
4.05e-46 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 163.63 E-value: 4.05e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159
|
....*..
gi 1864245115 377 NHFFSAQ 383
Cdd:pfam05729 160 RKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1527-1822 |
2.62e-36 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 144.16 E-value: 2.62e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1527 DLSHLLLNSSTLALLTHRLsqmtclQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE 1606
Cdd:COG5238 164 RLGLLAAISMAKALQNNSV------ETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1607 LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL--PQHLRVLHLPFSHLGPGGALSLAQALD 1684
Cdd:COG5238 238 LTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVNRIGDEGAIALAEGLQ 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1685 GSPHLEEISLAennlaggvlrfcmelpllrqidlvSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLP 1764
Cdd:COG5238 318 GNKTLHTLNLA------------------------YNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864245115 1765 QMGRLKRVDLEKNQITALGAWLLAEGLaQGSSIQVIRLWNNPIPCDMAQHLKSQEPRL 1822
Cdd:COG5238 374 GNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1493-1793 |
1.15e-32 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 130.17 E-value: 1.15e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1493 HHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSST--LALLTHRLSQMTCLQSLRLNRNSIGDVGCcHLS 1570
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLSDNALGPDGC-GVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1571 EALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE-LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPT 1649
Cdd:cd00116 102 ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1650 ALGLAQELP--QHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAggvlrfcmelpllrqidlvsckiDNQT 1727
Cdd:cd00116 182 IRALAEGLKanCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLT-----------------------DAGA 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245115 1728 AKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQ 1793
Cdd:cd00116 239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLE 304
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1483-1772 |
6.92e-32 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 131.07 E-value: 6.92e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1483 AHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIG 1562
Cdd:COG5238 170 AISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIG 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1563 DVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGC 1642
Cdd:COG5238 250 DEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAY 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1643 NALGDPTALGLAQELPQHLRV--LHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLagGVLRFcMELPLLRQIdlvs 1720
Cdd:COG5238 330 NGIGAQGAIALAKALQENTTLhsLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNI--GKQGA-EALIDALQT---- 402
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1864245115 1721 ckidNQTAKLLtssftscpalevilLSWNLLGDEAAAELAQVLPqmgRLKRV 1772
Cdd:COG5238 403 ----NRLHTLI--------------LDGNLIGAEAQQRLEQLLE---RIKSV 433
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1468-1684 |
4.17e-28 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 119.51 E-value: 4.17e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1468 KTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQ 1547
Cdd:COG5238 211 TTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQG 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1548 MTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAE 1627
Cdd:COG5238 291 NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAK 370
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245115 1628 SLVLCRRLEELMLGCNALGDPTALGLAQELpQHLRVLHLPFS--HLGPGGALSLAQALD 1684
Cdd:COG5238 371 YLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDgnLIGAEAQQRLEQLLE 428
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1478-1699 |
8.03e-28 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 116.30 E-value: 8.03e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1478 STEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGkWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRL 1556
Cdd:cd00116 66 IPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1557 NRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLE 1636
Cdd:cd00116 145 GRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLE 224
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245115 1637 ELMLGCNALGDPTALGLAQELP---QHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNL 1699
Cdd:cd00116 225 VLNLGDNNLTDAGAAALASALLspnISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKF 290
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
173-530 |
1.22e-22 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 106.04 E-value: 1.22e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635 131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635 211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635 284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635 362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864245115 480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635 436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1413-1638 |
2.09e-20 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 94.34 E-value: 2.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1413 LAHCDLGAHHS-------LLVGQLMETCARLQQLSLSQVNLCEDddasSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHL 1485
Cdd:cd00116 53 LKELCLSLNETgriprglQSLLQGLTKGCGLQELDLSDNALGPD----GCGVLESLLRSSSLQELKLNNNGLGDRGLRLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1486 ASGLGHCHH-----------------------------LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1536
Cdd:cd00116 129 AKGLKDLPPaleklvlgrnrlegascealakalranrdLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1537 TLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRA-ATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGN 1615
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250 260
....*....|....*....|....
gi 1864245115 1616 SISSAGGVQLAESLV-LCRRLEEL 1638
Cdd:cd00116 289 KFGEEGAQLLAESLLePGNELESL 312
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1489-1805 |
1.39e-18 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 90.38 E-value: 1.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1489 LGHCHHLEELDLSNNQfdeegtkalmrALEGKWMLKRLDLSHLLLNSstlalLTHRLSQMTCLQSLRLNRNSIGDvgcch 1568
Cdd:COG4886 92 LGDLTNLTELDLSGNE-----------ELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTD----- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1569 LSEALRAATSLEELDLSHNQIGDagvqhLATILPGLPELRKIDLSGNSISSaggvqLAESLVLCRRLEELMLGCNALGDp 1648
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD- 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1649 talgLAQELPQ--HLRVLHLPFSHlgpggaLSLAQALDGSPHLEEISLAENNLAGgvLRFCMELPLLRQIDLVSCKIDNQ 1726
Cdd:COG4886 220 ----LPEPLANltNLETLDLSNNQ------LTDLPELGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDL 287
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245115 1727 TAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNN 1805
Cdd:COG4886 288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1270-1658 |
2.89e-17 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 86.77 E-value: 2.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1270 PRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILlslvgrp 1349
Cdd:COG5238 156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEIL------- 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1350 aglfslrvqepwadrARVLSllevcaqasgsvteisisetqqqlcvqlefprqeENPeavalrlahcdlgahhsllvgql 1429
Cdd:COG5238 229 ---------------AEALK----------------------------------GNK----------------------- 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1430 metcaRLQQLSLSQVnlcedddasslllqslllslselktfrltssCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEG 1509
Cdd:COG5238 237 -----SLTTLDLSNN-------------------------------QIGDEGVIALAEALKNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1510 TKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQI 1589
Cdd:COG5238 281 AIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQI 360
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245115 1590 GDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLcRRLEELMLGCNALGDPTALGLAQELP 1658
Cdd:COG5238 361 GDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1550-1818 |
1.75e-16 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 82.79 E-value: 1.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1550 CLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIG--DAGVQHLATILPGLPELRKIDLSGNSISsAGGVQLAE 1627
Cdd:cd00116 24 CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALG-PDGCGVLE 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1628 SLVLCRRLEELMLGCNALGDptalglaqelpQHLRVLhlpfshlgpGGALslaqaLDGSPHLEEISLAENNLAGGvlrfC 1707
Cdd:cd00116 103 SLLRSSSLQELKLNNNGLGD-----------RGLRLL---------AKGL-----KDLPPALEKLVLGRNRLEGA----S 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1708 MElpllrqidlvsckidnQTAKLLTSSftscPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLL 1787
Cdd:cd00116 154 CE----------------ALAKALRAN----RDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASAL 213
|
250 260 270
....*....|....*....|....*....|.
gi 1864245115 1788 AEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQ 1818
Cdd:cd00116 214 AETLASLKSLEVLNLGDNNLTDAGAAALASA 244
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
751-1069 |
5.59e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 82.53 E-value: 5.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238 69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238 147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238 221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245115 991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238 281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
687-915 |
2.85e-14 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 77.14 E-value: 2.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 687 QIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVL 766
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 767 PHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFllspptETTAELqrAPDLQESDGQRkgaqsrslT 846
Cdd:COG5238 261 KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGD------EGAIAL--AEGLQGNKTLH--------T 324
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245115 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGV 915
Cdd:COG5238 325 LNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGA 393
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1482-1700 |
5.88e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 76.13 E-value: 5.88e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1482 LAHLASGLGHCHHLEELDLSNNQFDEegtkaLMRALEGKWMLKRLDLSHLLLNSstlalLTHRLSQMTCLQSLRLNRNSI 1561
Cdd:COG4886 148 LTDLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQL 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1562 GDvgcchLSEALRAATSLEELDLSHNQIGDAGVqhlatiLPGLPELRKIDLSGNSISSaggvqLAESLVLcRRLEELMLG 1641
Cdd:COG4886 218 TD-----LPEPLANLTNLETLDLSNNQLTDLPE------LGNLTNLEELDLSNNQLTD-----LPPLANL-TNLKTLDLS 280
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245115 1642 CNALGDP--TALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA 1700
Cdd:COG4886 281 NNQLTDLklKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
715-1052 |
1.41e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 75.21 E-value: 1.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 715 RLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVA 794
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 795 VTCPTVRmlqareadlifllspptettaelqrapdlqesdgqrkgaqsrslTLRLQKCQLQVHDAEALIALLQEGPHLEE 874
Cdd:COG5238 261 KNNTTVE--------------------------------------------TLYLSGNQIGAEGAIALAKALQGNTTLTS 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 875 VDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAVsacWTLAELHIslqhktvifmfaqepeeqkgp 954
Cdd:COG5238 297 LDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKAL---QENTTLHS--------------------- 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 955 qeraafldslmlqmpselplssrrmrlthcglqekhleqlckalggschlghlhLDFSGNALGDEGAARLAQLLPGLGAL 1034
Cdd:COG5238 353 ------------------------------------------------------LDLSDNQIGDEGAIALAKYLEGNTTL 378
|
330
....*....|....*...
gi 1864245115 1035 QSLNLSENGLSLDAVLGL 1052
Cdd:COG5238 379 RELNLGKNNIGKQGAEAL 396
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
690-1069 |
9.65e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 68.15 E-value: 9.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 690 NLSFKSRKCGDAFAEALSRSLPTMgrlQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQL--SDQVVLNIVEVLP 767
Cdd:cd00116 2 QLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 768 HLPRLRKLDLSSNSICvstllclarvAVTCPTVrmlqareadlifllspptettAELQRAPDLQEsdgqrkgaqsrsltL 847
Cdd:cd00116 79 KGCGLQELDLSDNALG----------PDGCGVL---------------------ESLLRSSSLQE--------------L 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 848 RLQKCQLQVhDAEALIA--LLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAvsac 925
Cdd:cd00116 114 KLNNNGLGD-RGLRLLAkgLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEG---- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 926 wtlaelhislqhktvifmfaqepeeqkgpqeraafldslmLQMPSELplssRRMRLTHCGLQEKHLEQLCKALGGSCHLg 1005
Cdd:cd00116 189 ----------------------------------------LKANCNL----EVLDLNNNGLTDEGASALAETLASLKSL- 223
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1864245115 1006 hLHLDFSGNALGDEGAARLA-QLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:cd00116 224 -EVLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRG 287
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
680-910 |
2.29e-11 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 68.28 E-value: 2.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 680 EALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVV 759
Cdd:COG5238 230 EALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGA 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 760 LNIVEVLPHLPRLRKLDLSSNSIcvstllclarvavtcptvrmlqaREADLIFLLspptettAELQRAPDLQesdgqrkg 839
Cdd:COG5238 310 IALAEGLQGNKTLHTLNLAYNGI-----------------------GAQGAIALA-------KALQENTTLH-------- 351
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245115 840 aqsrslTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAeAASQLHIARKLDLSNNGL 910
Cdd:COG5238 352 ------SLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALI-DALQTNRLHTLILDGNLI 415
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
661-893 |
7.37e-11 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 65.45 E-value: 7.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 661 REAPIHLDFDGCPLePHCPEAL--VGCGQienlsfksRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKAL 738
Cdd:cd00116 119 GLGDRGLRLLAKGL-KDLPPALekLVLGR--------NRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 739 PLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSIcvsTLLCLARVAvtcptvrmlqareadlifllsppt 818
Cdd:cd00116 190 KANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNL---TDAGAAALA------------------------ 242
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1864245115 819 ettaelqrapdlqesDGQRKGAQSRsLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEA 893
Cdd:cd00116 243 ---------------SALLSPNISL-LTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1575-1807 |
1.58e-10 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 65.58 E-value: 1.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1575 AATSLEELDLSHNQIGDAGVQHLATILPGLPElrkIDLSGNSISSAGGVQLAESLVLC-RRLEELMLGCNALGDPTALGL 1653
Cdd:COG5238 124 AKTLEDSLILYLALPRRINLIQVLKDPLGGNA---VHLLGLAARLGLLAAISMAKALQnNSVETVYLGCNQIGDEGIEEL 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1654 AQELPQH--LRVLHLPFSHLGPGGALSLAQALDGSPHLeeislaennlaggvlrfcmelpllRQIDLVsckiDNQtakll 1731
Cdd:COG5238 201 AEALTQNttVTTLWLKRNPIGDEGAEILAEALKGNKSL------------------------TTLDLS----NNQ----- 247
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245115 1732 tssftscpalevillswnlLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPI 1807
Cdd:COG5238 248 -------------------IGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRI 304
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1488-1638 |
1.77e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 62.88 E-value: 1.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1488 GLGHCHHLEELDLSNNQFDE-EGtkalmraLEGKWMLKRLDLSH--------LLLNSSTLALLTHrlsqmtCLQSLRLNR 1558
Cdd:cd21340 63 NLENLVNLKKLYLGGNRISVvEG-------LENLTNLEELHIENqrlppgekLTFDPRSLAALSN------SLRVLNISG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1559 NSIGDVgcchlsEALRAATSLEELDLSHNQIGDagVQHLATILPGLPELRKIDLSGNSISSagGVQLAESLVL-CRRLEE 1637
Cdd:cd21340 130 NNIDSL------EPLAPLRNLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVCK--KPKYRDKIILaSKSLEV 199
|
.
gi 1864245115 1638 L 1638
Cdd:cd21340 200 L 200
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
514-628 |
7.71e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 55.38 E-value: 7.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRW------VQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKREslksllDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1864245115 587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776 80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
666-914 |
4.49e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 53.90 E-value: 4.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 666 HLDFDGCPLEPHCPEALVGCGQI---ENLSFKSRKCGDAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLC 741
Cdd:cd00116 85 ELDLSDNALGPDGCGVLESLLRSsslQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRAN 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 742 PQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSIcvstllclarvavTCPTVRMLQAREADLIFLLspptett 821
Cdd:cd00116 165 RDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGL-------------TDEGASALAETLASLKSLE------- 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 822 aelqrapdlqesdgqrkgaqsrslTLRLQKCQLQVHDAEALI-ALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIA 900
Cdd:cd00116 225 ------------------------VLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESL 280
|
250
....*....|....
gi 1864245115 901 RKLDLSNNGLSVAG 914
Cdd:cd00116 281 LELDLRGNKFGEEG 294
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1526-1807 |
9.49e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 53.40 E-value: 9.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1526 LDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLP 1605
Cdd:COG4886 17 LLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1606 ELRKIDLSGNsissaggvqlaESLVLCRRLEELMLGCNALGDptalgLAQELPQ--HLRVLHLPFSHLGpggalSLAQAL 1683
Cdd:COG4886 97 NLTELDLSGN-----------EELSNLTNLESLDLSGNQLTD-----LPEELANltNLKELDLSNNQLT-----DLPEPL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1684 DGSPHLEEISLAENNLAGgvlrfcmelpllrqidlvsckidnqtaklLTSSFTSCPALEVILLSWNLLGDeaaaeLAQVL 1763
Cdd:COG4886 156 GNLTNLKSLDLSNNQLTD-----------------------------LPEELGNLTNLKELDLSNNQITD-----LPEPL 201
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1864245115 1764 PQMGRLKRVDLEKNQITALGawllaEGLAQGSSIQVIRLWNNPI 1807
Cdd:COG4886 202 GNLTNLEELDLSGNQLTDLP-----EPLANLTNLETLDLSNNQL 240
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1482-1675 |
3.79e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 51.47 E-value: 3.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1482 LAHLASGLGHCHHLEELDLSNNQFdeegtKALMRALEGKWMLKRLDLSHLLLnsSTLAllthRLSQMTCLQSLRLNRNSI 1561
Cdd:COG4886 194 ITDLPEPLGNLTNLEELDLSGNQL-----TDLPEPLANLTNLETLDLSNNQL--TDLP----ELGNLTNLEELDLSNNQL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1562 GDVGcchlseALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLG 1641
Cdd:COG4886 263 TDLP------PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336
|
170 180 190
....*....|....*....|....*....|....
gi 1864245115 1642 CNALGDPTALGLAQELPQHLRVLHLPFSHLGPGG 1675
Cdd:COG4886 337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
704-911 |
8.56e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 50.32 E-value: 8.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 704 EALSRSLPTMGRLQMLGLAGSKITargisHLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSIc 783
Cdd:COG4886 126 TDLPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQI- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 784 vSTL-LCLARvavtCPTVRMLQAREADLifllsppTETTAELQRAPDLQesdgqrkgaqsrslTLRLQKCQLQVhdaeal 862
Cdd:COG4886 195 -TDLpEPLGN----LTNLEELDLSGNQL-------TDLPEPLANLTNLE--------------TLDLSNNQLTD------ 242
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1864245115 863 IALLQEGPHLEEVDLSGNQLEDegcrlmAEAASQLHIARKLDLSNNGLS 911
Cdd:COG4886 243 LPELGNLTNLEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLT 285
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
845-1284 |
1.04e-05 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 49.66 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 845 LTLRLQKCQLQVHDAEALIALLQegpHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNN--GLSVAGVHCVLRAV 922
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLL---CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 923 SACWTLAELHISlqhktvifmfaqepeeqkgpqeRAAFLDSLMLQMPSELPLSS-RRMRLTHCGLQEKHLEQLCKALGG- 1000
Cdd:cd00116 78 TKGCGLQELDLS----------------------DNALGPDGCGVLESLLRSSSlQELKLNNNGLGDRGLRLLAKGLKDl 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1001 SCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDisfesqhillrgdk 1080
Cdd:cd00116 136 PPALEKLVL--GRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLD-------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1081 tsrdmwatgslpdfpaaakflgfrqrciprslcLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLp 1160
Cdd:cd00116 200 ---------------------------------LNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASAL- 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1161 qlpqlsllqlsqtglspkspfllantLSLCPRVKKVDLrslhhatlhfrsneeeegvccglSANLLGDSGLRCLLECLPQ 1240
Cdd:cd00116 246 --------------------------LSPNISLLTLSL-----------------------SCNDITDDGAKDLAEVLAE 276
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1864245115 1241 VPISGLLDLSHNSISQESALYLLETLpSCPRVREASVNLGSEQS 1284
Cdd:cd00116 277 KESLLELDLRGNKFGEEGAQLLAESL-LEPGNELESLWVKDDSF 319
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1489-1666 |
2.45e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 47.47 E-value: 2.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1489 LGHCHHLEELDLSNNQfdeegtkalmralegkwmLKRLDlshlllNSSTLALLTH------------RLSQMTCLQSLRL 1556
Cdd:cd21340 20 LSLCKNLKVLYLYDNK------------------ITKIE------NLEFLTNLTHlylqnnqiekieNLENLVNLKKLYL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1557 NRNSIGDVgcchlsEALRAATSLEELDLSHNQIgDAGVQHL---ATILPGLPELRKIDLSGNSISSaggvqlAESLVLCR 1633
Cdd:cd21340 76 GGNRISVV------EGLENLTNLEELHIENQRL-PPGEKLTfdpRSLAALSNSLRVLNISGNNIDS------LEPLAPLR 142
|
170 180 190
....*....|....*....|....*....|....
gi 1864245115 1634 RLEELMLGCNALGDPTAL-GLAQELPQhLRVLHL 1666
Cdd:cd21340 143 NLEQLDASNNQISDLEELlDLLSSWPS-LRELDL 175
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1523-1781 |
4.59e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 46.70 E-value: 4.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1523 LKRLdlSHLLLNSSTLALLtHRLSQMTCLQSLRLNRNSIGDVgcchlsEALRAATSLEELDLSHNQIgdagvqhlATI-- 1600
Cdd:cd21340 1 LKRI--THLYLNDKNITKI-DNLSLCKNLKVLYLYDNKITKI------ENLEFLTNLTHLYLQNNQI--------EKIen 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1601 LPGLPELRKIDLSGNSISSaggvqlAESLVLCRRLEELMLGCnalgdptalglaQELPQHLRVLHLPFSHLgpggalsla 1680
Cdd:cd21340 64 LENLVNLKKLYLGGNRISV------VEGLENLTNLEELHIEN------------QRLPPGEKLTFDPRSLA--------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1681 qaldgsphleeiSLAENnlaggvlrfcmelplLRQIDLVSCKIDNqtakllTSSFTSCPALEVILLSWNLLGDeaAAELA 1760
Cdd:cd21340 117 ------------ALSNS---------------LRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQISD--LEELL 161
|
250 260
....*....|....*....|.
gi 1864245115 1761 QVLPQMGRLKRVDLEKNQITA 1781
Cdd:cd21340 162 DLLSSWPSLRELDLTGNPVCK 182
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
716-911 |
5.25e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 47.62 E-value: 5.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 716 LQMLGLAGSKITargisHLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSICVstllcLARVAV 795
Cdd:COG4886 115 LESLDLSGNQLT-----DLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEELG 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 796 TCPTVRMLQAREADLifllsppTETTAELQRAPDLQEsdgqrkgaqsrsltLRLQKCQLQvhDAEALIALLqegPHLEEV 875
Cdd:COG4886 180 NLTNLKELDLSNNQI-------TDLPEPLGNLTNLEE--------------LDLSGNQLT--DLPEPLANL---TNLETL 233
|
170 180 190
....*....|....*....|....*....|....*.
gi 1864245115 876 DLSGNQLEDegcrlmAEAASQLHIARKLDLSNNGLS 911
Cdd:COG4886 234 DLSNNQLTD------LPELGNLTNLEELDLSNNQLT 263
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
649-782 |
2.50e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 45.69 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886 153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1864245115 729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1551-1617 |
2.53e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 2.53e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245115 1551 LQSLRLNRNSIGDVGcchlSEALRAATSLEELDLSHNQIGdagvqhlaTILP----GLPELRKIDLSGNSI 1617
Cdd:pfam13855 3 LRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLLT--------TLSPgafsGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1009-1336 |
4.36e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 44.65 E-value: 4.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1009 LDFSGNALGDEGAArlaQLLPGLGALQSLNLSENGLSLDAVLGLVRcfstlqwlfRLDISFESQHILLRGDKTSRDMWAT 1088
Cdd:cd00116 3 LSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLSLNETGRIPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1089 GSLPD-------------------FPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLE-LQLSCEFLS 1148
Cdd:cd00116 71 QSLLQgltkgcglqeldlsdnalgPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEkLVLGRNRLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1149 DQSLETLldclpqlpqlsllqlsqtglspkspfllANTLSLCPRVKKVDLR--SLHHATLH-----FRSNEEEEGVccGL 1221
Cdd:cd00116 151 GASCEAL----------------------------AKALRANRDLKELNLAnnGIGDAGIRalaegLKANCNLEVL--DL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1222 SANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPScprvreasvnlgseqsfrihfsrEDQAGKTLRL 1301
Cdd:cd00116 201 NNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLS-----------------------PNISLLTLSL 257
|
330 340 350
....*....|....*....|....*....|....*
gi 1864245115 1302 SECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQ 1336
Cdd:cd00116 258 SCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGE 292
|
|
| LRR_6 |
pfam13516 |
Leucine Rich repeat; |
1577-1598 |
6.48e-04 |
|
Leucine Rich repeat;
Pssm-ID: 463907 [Multi-domain] Cd Length: 24 Bit Score: 38.37 E-value: 6.48e-04
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
1519-1618 |
1.37e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 43.65 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1519 GKWMLKRLDLShlllNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVgcchLSEALRAATSLEELDLSHNQIGDAgvqhLA 1598
Cdd:PLN03150 416 GKWFIDGLGLD----NQGLRGFIPNDISKLRHLQSINLSGNSIRGN----IPPSLGSITSLEVLDLSYNSFNGS----IP 483
|
90 100
....*....|....*....|
gi 1864245115 1599 TILPGLPELRKIDLSGNSIS 1618
Cdd:PLN03150 484 ESLGQLTSLRILNLNGNSLS 503
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
650-782 |
1.98e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 42.61 E-value: 1.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 650 DLATLTNIlehreapIHLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITAr 729
Cdd:COG4886 131 ELANLTNL-------KELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD- 196
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1864245115 730 gishLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 197 ----LPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQL 240
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
680-772 |
3.35e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.08 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 680 EALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALpLCPQLKEVSFRDNQLSDQVV 759
Cdd:COG5238 342 KALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQ 420
|
90
....*....|...
gi 1864245115 760 LNIVEVLPHLPRL 772
Cdd:COG5238 421 QRLEQLLERIKSV 433
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
1577-1615 |
3.71e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.84 E-value: 3.71e-03
10 20 30
....*....|....*....|....*....|....*....
gi 1864245115 1577 TSLEELDLSHNQIGDAGvqhlatILPGLPELRKIDLSGN 1615
Cdd:pfam12799 1 PNLEVLDLSNNQITDIP------PLAKLPNLETLDLSGN 33
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1495-1780 |
5.24e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 41.76 E-value: 5.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1495 LEELDLSNNQFDEE-----GTKALMRALE--GKWMLKRLDLShlLLNSSTLALLT-----------HRLSQMTCLQSLRL 1556
Cdd:PLN00113 142 LETLDLSNNMLSGEipndiGSFSSLKVLDlgGNVLVGKIPNS--LTNLTSLEFLTlasnqlvgqipRELGQMKSLKWIYL 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1557 NRNSIGDvgccHLSEALRAATSLEELDLSHNQIgdagvqhLATILPGLPELRKID---LSGNSISSaggvQLAESLVLCR 1633
Cdd:PLN00113 220 GYNNLSG----EIPYEIGGLTSLNHLDLVYNNL-------TGPIPSSLGNLKNLQylfLYQNKLSG----PIPPSIFSLQ 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1634 RLEELMLGCNALGDPTALGLAQElpQHLRVLHLPFSHLG---PGGALSLaqaldgsPHLEEISLAENNLAGGVLRFCMEL 1710
Cdd:PLN00113 285 KLISLDLSDNSLSGEIPELVIQL--QNLEILHLFSNNFTgkiPVALTSL-------PRLQVLQLWSNKFSGEIPKNLGKH 355
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 1711 PLLRQIDLVSckiDNQTAKLLTSSFTSCPALEVILLSWNLLGdeaaaELAQVLPQMGRLKRVDLEKNQIT 1780
Cdd:PLN00113 356 NNLTVLDLST---NNLTGEIPEGLCSSGNLFKLILFSNSLEG-----EIPKSLGACRSLRRVRLQDNSFS 417
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1577-1598 |
6.16e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 35.85 E-value: 6.16e-03
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
705-783 |
7.51e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 39.77 E-value: 7.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245115 705 ALSRSLptmgrlQMLGLAGSKITA-RGISHLVkalplcpQLKEVSFRDNQLSDqvVLNIVEVLPHLPRLRKLDLSSNSIC 783
Cdd:cd21340 117 ALSNSL------RVLNISGNNIDSlEPLAPLR-------NLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVC 181
|
|
| |
