|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-95 |
6.20e-53 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
:
Pssm-ID: 436519 Cd Length: 95 Bit Score: 180.22 E-value: 6.20e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1864245113 81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
222-383 |
3.12e-46 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 164.02 E-value: 3.12e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159
|
....*..
gi 1864245113 377 NHFFSAQ 383
Cdd:pfam05729 160 RKYFSDE 166
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1497-1792 |
1.73e-36 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 144.55 E-value: 1.73e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1497 DLSHLLLNSSTLALLTHRLsqmtclQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE 1576
Cdd:COG5238 164 RLGLLAAISMAKALQNNSV------ETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1577 LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL--PQHLRVLHLPFSHLGPGGALSLAQALD 1654
Cdd:COG5238 238 LTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVNRIGDEGAIALAEGLQ 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1655 GSPHLEEISLAennlaggvlrfcmelpllrqidlvSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLP 1734
Cdd:COG5238 318 GNKTLHTLNLA------------------------YNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864245113 1735 QMGRLKRVDLEKNQITALGAWLLAEGLaQGSSIQVIRLWNNPIPCDMAQHLKSQEPRL 1792
Cdd:COG5238 374 GNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
173-530 |
7.91e-23 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
:
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 106.43 E-value: 7.91e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635 131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635 211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635 284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635 362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864245113 480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635 436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1383-1608 |
1.68e-20 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 94.73 E-value: 1.68e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1383 LAHCDLGAHHS-------LLVGQLMETCARLQQLSLSQVNLCEDddasSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHL 1455
Cdd:cd00116 53 LKELCLSLNETgriprglQSLLQGLTKGCGLQELDLSDNALGPD----GCGVLESLLRSSSLQELKLNNNGLGDRGLRLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1456 ASGLGHCHH-----------------------------LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1506
Cdd:cd00116 129 AKGLKDLPPaleklvlgrnrlegascealakalranrdLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1507 TLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRA-ATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGN 1585
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250 260
....*....|....*....|....
gi 1864245113 1586 SISSAGGVQLAESLV-LCRRLEEL 1608
Cdd:cd00116 289 KFGEEGAQLLAESLLePGNELESL 312
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
751-1069 |
4.23e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 82.92 E-value: 4.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238 69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238 147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238 221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245113 991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238 281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
|
|
| NLRC4_HD2 super family |
cl39284 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
514-628 |
7.88e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
The actual alignment was detected with superfamily member pfam17776:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 55.38 E-value: 7.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRW------VQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKREslksllDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1864245113 587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776 80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
|
|
| LRR super family |
cl34836 |
Leucine-rich repeat (LRR) protein [Transcription]; |
649-782 |
1.60e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
The actual alignment was detected with superfamily member COG4886:
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 46.08 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886 153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1864245113 729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1009-1373 |
7.05e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 40.80 E-value: 7.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1009 LDFSGNALGDEGAArlaQLLPGLGALQSLNLSENGLSLDAVLGLVRcfstlqwlfRLDISFESQHILLRGDKTSRDMWAT 1088
Cdd:cd00116 3 LSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLSLNETGRIPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1089 GSLPDfpaaakflGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDcpGPL-ELQLSCEFLSDQSLetlldclpqlpqlsl 1167
Cdd:cd00116 71 QSLLQ--------GLTKGCGLQELDLSDNALGPDGCGVLESLLRS--SSLqELKLNNNGLGDRGL--------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1168 lqlsqtglspksPFLLANTLSLCPRVKKVDLrslhhatlhfrsneeeegvccgfTGCSLSQEHVESLCWLLSKCKDLSQV 1247
Cdd:cd00116 126 ------------RLLAKGLKDLPPALEKLVL-----------------------GRNRLEGASCEALAKALRANRDLKEL 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1248 DLG----SEQSFR--IHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSlvGRPAG 1321
Cdd:cd00116 171 NLAnngiGDAGIRalAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALAS--ALLSP 248
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1864245113 1322 LFSLrvqepwadraRVLSLLEVCAQASGSVTEisiSETQQQLCVQLEFPRQE 1373
Cdd:cd00116 249 NISL----------LTLSLSCNDITDDGAKDL---AEVLAEKESLLELDLRG 287
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-95 |
6.20e-53 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 180.22 E-value: 6.20e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1864245113 81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
222-383 |
3.12e-46 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 164.02 E-value: 3.12e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159
|
....*..
gi 1864245113 377 NHFFSAQ 383
Cdd:pfam05729 160 RKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1497-1792 |
1.73e-36 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 144.55 E-value: 1.73e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1497 DLSHLLLNSSTLALLTHRLsqmtclQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE 1576
Cdd:COG5238 164 RLGLLAAISMAKALQNNSV------ETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1577 LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL--PQHLRVLHLPFSHLGPGGALSLAQALD 1654
Cdd:COG5238 238 LTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVNRIGDEGAIALAEGLQ 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1655 GSPHLEEISLAennlaggvlrfcmelpllrqidlvSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLP 1734
Cdd:COG5238 318 GNKTLHTLNLA------------------------YNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864245113 1735 QMGRLKRVDLEKNQITALGAWLLAEGLaQGSSIQVIRLWNNPIPCDMAQHLKSQEPRL 1792
Cdd:COG5238 374 GNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1463-1763 |
8.68e-33 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 130.55 E-value: 8.68e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1463 HHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSST--LALLTHRLSQMTCLQSLRLNRNSIGDVGCcHLS 1540
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLSDNALGPDGC-GVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1541 EALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE-LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPT 1619
Cdd:cd00116 102 ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1620 ALGLAQELP--QHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAggvlrfcmelpllrqidlvsckiDNQT 1697
Cdd:cd00116 182 IRALAEGLKanCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLT-----------------------DAGA 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245113 1698 AKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQ 1763
Cdd:cd00116 239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLE 304
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
173-530 |
7.91e-23 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 106.43 E-value: 7.91e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635 131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635 211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635 284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635 362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864245113 480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635 436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1383-1608 |
1.68e-20 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 94.73 E-value: 1.68e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1383 LAHCDLGAHHS-------LLVGQLMETCARLQQLSLSQVNLCEDddasSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHL 1455
Cdd:cd00116 53 LKELCLSLNETgriprglQSLLQGLTKGCGLQELDLSDNALGPD----GCGVLESLLRSSSLQELKLNNNGLGDRGLRLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1456 ASGLGHCHH-----------------------------LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1506
Cdd:cd00116 129 AKGLKDLPPaleklvlgrnrlegascealakalranrdLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1507 TLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRA-ATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGN 1585
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250 260
....*....|....*....|....
gi 1864245113 1586 SISSAGGVQLAESLV-LCRRLEEL 1608
Cdd:cd00116 289 KFGEEGAQLLAESLLePGNELESL 312
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1243-1628 |
3.91e-17 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 86.38 E-value: 3.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1243 DLSQVDLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILlslvgrpagl 1322
Cdd:COG5238 159 LGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEIL---------- 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1323 fslrvqepwadrARVLSllevcaqasgsvteisisetqqqlcvqlefprqeENPeavalrlahcdlgahhsllvgqlmet 1402
Cdd:COG5238 229 ------------AEALK----------------------------------GNK-------------------------- 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1403 caRLQQLSLSQVnlcedddasslllqslllslselktfrltssCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKA 1482
Cdd:COG5238 237 --SLTTLDLSNN-------------------------------QIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIA 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1483 LMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDA 1562
Cdd:COG5238 284 LAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDE 363
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245113 1563 GVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLcRRLEELMLGCNALGDPTALGLAQELP 1628
Cdd:COG5238 364 GAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
751-1069 |
4.23e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 82.92 E-value: 4.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238 69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238 147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238 221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245113 991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238 281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
745-1069 |
1.29e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 70.85 E-value: 1.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 745 KEVSFRDNQLSDQVVLnivEVLPHLPRLRKLDLSSNSICVSTLLCLARvavtcptvrMLQAREADLIFLLSpptetTAEL 824
Cdd:cd00116 1 LQLSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLS-----LNET 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 825 QRAPDLQESDGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQeGPHLEEVDLSGNQLEDEGCRLMAEAASQL-HIARKL 903
Cdd:cd00116 64 GRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLR-SSSLQELKLNNNGLGDRGLRLLAKGLKDLpPALEKL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 904 DLSNNGLSVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepeeQKGPQERAAFLDSLMLQMPSELplssRRMRLTH 983
Cdd:cd00116 143 VLGRNRLEGASCEALAKALRANRDLKELNLA----------------NNGIGDAGIRALAEGLKANCNL----EVLDLNN 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 984 CGLQEKHLEQLCKALGGSCHLghLHLDFSGNALGDEGAARLA-QLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWL 1062
Cdd:cd00116 203 NGLTDEGASALAETLASLKSL--EVLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESL 280
|
....*..
gi 1864245113 1063 FRLDISF 1069
Cdd:cd00116 281 LELDLRG 287
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
514-628 |
7.88e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 55.38 E-value: 7.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRW------VQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKREslksllDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1864245113 587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776 80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
649-782 |
1.60e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 46.08 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886 153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1864245113 729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1521-1587 |
1.91e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.97 E-value: 1.91e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245113 1521 LQSLRLNRNSIGDVGcchlSEALRAATSLEELDLSHNQIGdagvqhlaTILP----GLPELRKIDLSGNSI 1587
Cdd:pfam13855 3 LRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLLT--------TLSPgafsGLPSLRYLDLSGNRL 61
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
1489-1588 |
1.34e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 43.65 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1489 GKWMLKRLDLShlllNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVgcchLSEALRAATSLEELDLSHNQIGDAgvqhLA 1568
Cdd:PLN03150 416 GKWFIDGLGLD----NQGLRGFIPNDISKLRHLQSINLSGNSIRGN----IPPSLGSITSLEVLDLSYNSFNGS----IP 483
|
90 100
....*....|....*....|
gi 1864245113 1569 TILPGLPELRKIDLSGNSIS 1588
Cdd:PLN03150 484 ESLGQLTSLRILNLNGNSLS 503
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1547-1568 |
5.49e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 35.85 E-value: 5.49e-03
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
705-783 |
6.62e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.15 E-value: 6.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 705 ALSRSLptmgrlQMLGLAGSKITA-RGISHLVkalplcpQLKEVSFRDNQLSDqvVLNIVEVLPHLPRLRKLDLSSNSIC 783
Cdd:cd21340 117 ALSNSL------RVLNISGNNIDSlEPLAPLR-------NLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVC 181
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1009-1373 |
7.05e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.80 E-value: 7.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1009 LDFSGNALGDEGAArlaQLLPGLGALQSLNLSENGLSLDAVLGLVRcfstlqwlfRLDISFESQHILLRGDKTSRDMWAT 1088
Cdd:cd00116 3 LSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLSLNETGRIPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1089 GSLPDfpaaakflGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDcpGPL-ELQLSCEFLSDQSLetlldclpqlpqlsl 1167
Cdd:cd00116 71 QSLLQ--------GLTKGCGLQELDLSDNALGPDGCGVLESLLRS--SSLqELKLNNNGLGDRGL--------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1168 lqlsqtglspksPFLLANTLSLCPRVKKVDLrslhhatlhfrsneeeegvccgfTGCSLSQEHVESLCWLLSKCKDLSQV 1247
Cdd:cd00116 126 ------------RLLAKGLKDLPPALEKLVL-----------------------GRNRLEGASCEALAKALRANRDLKEL 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1248 DLG----SEQSFR--IHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSlvGRPAG 1321
Cdd:cd00116 171 NLAnngiGDAGIRalAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALAS--ALLSP 248
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1864245113 1322 LFSLrvqepwadraRVLSLLEVCAQASGSVTEisiSETQQQLCVQLEFPRQE 1373
Cdd:cd00116 249 NISL----------LTLSLSCNDITDDGAKDL---AEVLAEKESLLELDLRG 287
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-95 |
6.20e-53 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 180.22 E-value: 6.20e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1864245113 81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
222-383 |
3.12e-46 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 164.02 E-value: 3.12e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159
|
....*..
gi 1864245113 377 NHFFSAQ 383
Cdd:pfam05729 160 RKYFSDE 166
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1497-1792 |
1.73e-36 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 144.55 E-value: 1.73e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1497 DLSHLLLNSSTLALLTHRLsqmtclQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE 1576
Cdd:COG5238 164 RLGLLAAISMAKALQNNSV------ETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1577 LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL--PQHLRVLHLPFSHLGPGGALSLAQALD 1654
Cdd:COG5238 238 LTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVNRIGDEGAIALAEGLQ 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1655 GSPHLEEISLAennlaggvlrfcmelpllrqidlvSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLP 1734
Cdd:COG5238 318 GNKTLHTLNLA------------------------YNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864245113 1735 QMGRLKRVDLEKNQITALGAWLLAEGLaQGSSIQVIRLWNNPIPCDMAQHLKSQEPRL 1792
Cdd:COG5238 374 GNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1463-1763 |
8.68e-33 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 130.55 E-value: 8.68e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1463 HHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSST--LALLTHRLSQMTCLQSLRLNRNSIGDVGCcHLS 1540
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLSDNALGPDGC-GVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1541 EALRAATSLEELDLSHNQIGDAGVQHLATILPGLPE-LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPT 1619
Cdd:cd00116 102 ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1620 ALGLAQELP--QHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAggvlrfcmelpllrqidlvsckiDNQT 1697
Cdd:cd00116 182 IRALAEGLKanCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLT-----------------------DAGA 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245113 1698 AKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQ 1763
Cdd:cd00116 239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLE 304
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1453-1742 |
5.13e-32 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 131.45 E-value: 5.13e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1453 AHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIG 1532
Cdd:COG5238 170 AISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIG 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1533 DVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGC 1612
Cdd:COG5238 250 DEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAY 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1613 NALGDPTALGLAQELPQHLRV--LHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLagGVLRFcMELPLLRQIdlvs 1690
Cdd:COG5238 330 NGIGAQGAIALAKALQENTTLhsLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNI--GKQGA-EALIDALQT---- 402
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1864245113 1691 ckidNQTAKLLtssftscpalevilLSWNLLGDEAAAELAQVLPqmgRLKRV 1742
Cdd:COG5238 403 ----NRLHTLI--------------LDGNLIGAEAQQRLEQLLE---RIKSV 433
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1438-1654 |
3.53e-28 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 119.89 E-value: 3.53e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1438 KTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQ 1517
Cdd:COG5238 211 TTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQG 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1518 MTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAE 1597
Cdd:COG5238 291 NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAK 370
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245113 1598 SLVLCRRLEELMLGCNALGDPTALGLAQELpQHLRVLHLPFS--HLGPGGALSLAQALD 1654
Cdd:COG5238 371 YLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDgnLIGAEAQQRLEQLLE 428
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1448-1669 |
5.99e-28 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 116.69 E-value: 5.99e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1448 STEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGkWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRL 1526
Cdd:cd00116 66 IPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1527 NRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLE 1606
Cdd:cd00116 145 GRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLE 224
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245113 1607 ELMLGCNALGDPTALGLAQELP---QHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNL 1669
Cdd:cd00116 225 VLNLGDNNLTDAGAAALASALLspnISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKF 290
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
173-530 |
7.91e-23 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 106.43 E-value: 7.91e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635 131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635 211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635 284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635 362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864245113 480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635 436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1383-1608 |
1.68e-20 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 94.73 E-value: 1.68e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1383 LAHCDLGAHHS-------LLVGQLMETCARLQQLSLSQVNLCEDddasSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHL 1455
Cdd:cd00116 53 LKELCLSLNETgriprglQSLLQGLTKGCGLQELDLSDNALGPD----GCGVLESLLRSSSLQELKLNNNGLGDRGLRLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1456 ASGLGHCHH-----------------------------LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1506
Cdd:cd00116 129 AKGLKDLPPaleklvlgrnrlegascealakalranrdLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1507 TLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRA-ATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGN 1585
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250 260
....*....|....*....|....
gi 1864245113 1586 SISSAGGVQLAESLV-LCRRLEEL 1608
Cdd:cd00116 289 KFGEEGAQLLAESLLePGNELESL 312
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1459-1775 |
6.00e-19 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 91.53 E-value: 6.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1459 LGHCHHLEELDLSNNQfdeegtkalmrALEGKWMLKRLDLSHLLLNSstlalLTHRLSQMTCLQSLRLNRNSIGDvgcch 1538
Cdd:COG4886 92 LGDLTNLTELDLSGNE-----------ELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTD----- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1539 LSEALRAATSLEELDLSHNQIGDagvqhLATILPGLPELRKIDLSGNSISSaggvqLAESLVLCRRLEELMLGCNALGDp 1618
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD- 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1619 talgLAQELPQ--HLRVLHLPFSHlgpggaLSLAQALDGSPHLEEISLAENNLAGgvLRFCMELPLLRQIDLVSCKIDNQ 1696
Cdd:COG4886 220 ----LPEPLANltNLETLDLSNNQ------LTDLPELGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDL 287
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245113 1697 TAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNN 1775
Cdd:COG4886 288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1243-1628 |
3.91e-17 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 86.38 E-value: 3.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1243 DLSQVDLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILlslvgrpagl 1322
Cdd:COG5238 159 LGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEIL---------- 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1323 fslrvqepwadrARVLSllevcaqasgsvteisisetqqqlcvqlefprqeENPeavalrlahcdlgahhsllvgqlmet 1402
Cdd:COG5238 229 ------------AEALK----------------------------------GNK-------------------------- 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1403 caRLQQLSLSQVnlcedddasslllqslllslselktfrltssCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKA 1482
Cdd:COG5238 237 --SLTTLDLSNN-------------------------------QIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIA 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1483 LMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDA 1562
Cdd:COG5238 284 LAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDE 363
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245113 1563 GVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLcRRLEELMLGCNALGDPTALGLAQELP 1628
Cdd:COG5238 364 GAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1520-1788 |
1.58e-16 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 82.79 E-value: 1.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1520 CLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIG--DAGVQHLATILPGLPELRKIDLSGNSISsAGGVQLAE 1597
Cdd:cd00116 24 CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALG-PDGCGVLE 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1598 SLVLCRRLEELMLGCNALGDptalglaqelpQHLRVLhlpfshlgpGGALslaqaLDGSPHLEEISLAENNLAGGvlrfC 1677
Cdd:cd00116 103 SLLRSSSLQELKLNNNGLGD-----------RGLRLL---------AKGL-----KDLPPALEKLVLGRNRLEGA----S 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1678 MElpllrqidlvsckidnQTAKLLTSSftscPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLL 1757
Cdd:cd00116 154 CE----------------ALAKALRAN----RDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASAL 213
|
250 260 270
....*....|....*....|....*....|.
gi 1864245113 1758 AEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQ 1788
Cdd:cd00116 214 AETLASLKSLEVLNLGDNNLTDAGAAALASA 244
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
751-1069 |
4.23e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 82.92 E-value: 4.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238 69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238 147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238 221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245113 991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238 281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
687-915 |
2.28e-14 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 77.52 E-value: 2.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 687 QIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVL 766
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 767 PHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFllspptETTAELqrAPDLQESDGQRkgaqsrslT 846
Cdd:COG5238 261 KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGD------EGAIAL--AEGLQGNKTLH--------T 324
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245113 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGV 915
Cdd:COG5238 325 LNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGA 393
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1452-1670 |
3.30e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 76.90 E-value: 3.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1452 LAHLASGLGHCHHLEELDLSNNQFDEegtkaLMRALEGKWMLKRLDLSHLLLNSstlalLTHRLSQMTCLQSLRLNRNSI 1531
Cdd:COG4886 148 LTDLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQL 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1532 GDvgcchLSEALRAATSLEELDLSHNQIGDAGVqhlatiLPGLPELRKIDLSGNSISSaggvqLAESLVLcRRLEELMLG 1611
Cdd:COG4886 218 TD-----LPEPLANLTNLETLDLSNNQLTDLPE------LGNLTNLEELDLSNNQLTD-----LPPLANL-TNLKTLDLS 280
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245113 1612 CNALGDP--TALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA 1670
Cdd:COG4886 281 NNQLTDLklKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
715-1052 |
1.07e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 75.60 E-value: 1.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 715 RLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVA 794
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 795 VTCPTVRmlqareadlifllspptettaelqrapdlqesdgqrkgaqsrslTLRLQKCQLQVHDAEALIALLQEGPHLEE 874
Cdd:COG5238 261 KNNTTVE--------------------------------------------TLYLSGNQIGAEGAIALAKALQGNTTLTS 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 875 VDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAVsacWTLAELHIslqhktvifmfaqepeeqkgp 954
Cdd:COG5238 297 LDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKAL---QENTTLHS--------------------- 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 955 qeraafldslmlqmpselplssrrmrlthcglqekhleqlckalggschlghlhLDFSGNALGDEGAARLAQLLPGLGAL 1034
Cdd:COG5238 353 ------------------------------------------------------LDLSDNQIGDEGAIALAKYLEGNTTL 378
|
330
....*....|....*...
gi 1864245113 1035 QSLNLSENGLSLDAVLGL 1052
Cdd:COG5238 379 RELNLGKNNIGKQGAEAL 396
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
745-1069 |
1.29e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 70.85 E-value: 1.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 745 KEVSFRDNQLSDQVVLnivEVLPHLPRLRKLDLSSNSICVSTLLCLARvavtcptvrMLQAREADLIFLLSpptetTAEL 824
Cdd:cd00116 1 LQLSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLS-----LNET 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 825 QRAPDLQESDGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQeGPHLEEVDLSGNQLEDEGCRLMAEAASQL-HIARKL 903
Cdd:cd00116 64 GRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLR-SSSLQELKLNNNGLGDRGLRLLAKGLKDLpPALEKL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 904 DLSNNGLSVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepeeQKGPQERAAFLDSLMLQMPSELplssRRMRLTH 983
Cdd:cd00116 143 VLGRNRLEGASCEALAKALRANRDLKELNLA----------------NNGIGDAGIRALAEGLKANCNL----EVLDLNN 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 984 CGLQEKHLEQLCKALGGSCHLghLHLDFSGNALGDEGAARLA-QLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWL 1062
Cdd:cd00116 203 NGLTDEGASALAETLASLKSL--EVLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESL 280
|
....*..
gi 1864245113 1063 FRLDISF 1069
Cdd:cd00116 281 LELDLRG 287
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
680-910 |
1.97e-11 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 68.28 E-value: 1.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 680 EALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVV 759
Cdd:COG5238 230 EALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGA 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 760 LNIVEVLPHLPRLRKLDLSSNSIcvstllclarvavtcptvrmlqaREADLIFLLspptettAELQRAPDLQesdgqrkg 839
Cdd:COG5238 310 IALAEGLQGNKTLHTLNLAYNGI-----------------------GAQGAIALA-------KALQENTTLH-------- 351
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245113 840 aqsrslTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAeAASQLHIARKLDLSNNGL 910
Cdd:COG5238 352 ------SLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALI-DALQTNRLHTLILDGNLI 415
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
661-893 |
5.56e-11 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 65.84 E-value: 5.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 661 REAPIHLDFDGCPLePHCPEAL--VGCGQienlsfksRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKAL 738
Cdd:cd00116 119 GLGDRGLRLLAKGL-KDLPPALekLVLGR--------NRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 739 PLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSIcvsTLLCLARVAvtcptvrmlqareadlifllsppt 818
Cdd:cd00116 190 KANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNL---TDAGAAALA------------------------ 242
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1864245113 819 ettaelqrapdlqesDGQRKGAQSRsLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEA 893
Cdd:cd00116 243 ---------------SALLSPNISL-LTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1458-1608 |
1.31e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 63.27 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1458 GLGHCHHLEELDLSNNQFDE-EGtkalmraLEGKWMLKRLDLSH--------LLLNSSTLALLTHrlsqmtCLQSLRLNR 1528
Cdd:cd21340 63 NLENLVNLKKLYLGGNRISVvEG-------LENLTNLEELHIENqrlppgekLTFDPRSLAALSN------SLRVLNISG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1529 NSIGDVgcchlsEALRAATSLEELDLSHNQIGDagVQHLATILPGLPELRKIDLSGNSISSagGVQLAESLVL-CRRLEE 1607
Cdd:cd21340 130 NNIDSL------EPLAPLRNLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVCK--KPKYRDKIILaSKSLEV 199
|
.
gi 1864245113 1608 L 1608
Cdd:cd21340 200 L 200
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1545-1777 |
1.35e-10 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 65.58 E-value: 1.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1545 AATSLEELDLSHNQIGDAGVQHLATILPGLPElrkIDLSGNSISSAGGVQLAESLVLC-RRLEELMLGCNALGDPTALGL 1623
Cdd:COG5238 124 AKTLEDSLILYLALPRRINLIQVLKDPLGGNA---VHLLGLAARLGLLAAISMAKALQnNSVETVYLGCNQIGDEGIEEL 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1624 AQELPQH--LRVLHLPFSHLGPGGALSLAQALDGSPHLeeislaennlaggvlrfcmelpllRQIDLVsckiDNQtakll 1701
Cdd:COG5238 201 AEALTQNttVTTLWLKRNPIGDEGAEILAEALKGNKSL------------------------TTLDLS----NNQ----- 247
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245113 1702 tssftscpalevillswnlLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPI 1777
Cdd:COG5238 248 -------------------IGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRI 304
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
514-628 |
7.88e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 55.38 E-value: 7.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRW------VQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKREslksllDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1864245113 587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776 80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
845-1155 |
9.18e-08 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 55.82 E-value: 9.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 845 LTLRLQKCQLQVHDAEALIALLQegpHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNN--GLSVAGVHCVLRAV 922
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLL---CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 923 SACWTLAELHISlqhktvifmfaqepeeqkgpqeRAAFLDSLMLQMPSELPLSS-RRMRLTHCGLQEKHLEQLCKALGG- 1000
Cdd:cd00116 78 TKGCGLQELDLS----------------------DNALGPDGCGVLESLLRSSSlQELKLNNNGLGDRGLRLLAKGLKDl 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1001 SCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDIsfesqHILLRGDK 1080
Cdd:cd00116 136 PPALEKLVL--GRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDL-----NNNGLTDE 208
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864245113 1081 TSRDMWATgslpdfpaaakflgFRQRCIPRSLCLSECPLEPPSLTRLC-ATLKDCPGPLELQLSCEFLSDQSLETL 1155
Cdd:cd00116 209 GASALAET--------------LASLKSLEVLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDL 270
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
666-914 |
3.75e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 54.28 E-value: 3.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 666 HLDFDGCPLEPHCPEALVGCGQI---ENLSFKSRKCGDAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLC 741
Cdd:cd00116 85 ELDLSDNALGPDGCGVLESLLRSsslQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRAN 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 742 PQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSIcvstllclarvavTCPTVRMLQAREADLIFLLspptett 821
Cdd:cd00116 165 RDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGL-------------TDEGASALAETLASLKSLE------- 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 822 aelqrapdlqesdgqrkgaqsrslTLRLQKCQLQVHDAEALI-ALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIA 900
Cdd:cd00116 225 ------------------------VLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESL 280
|
250
....*....|....
gi 1864245113 901 RKLDLSNNGLSVAG 914
Cdd:cd00116 281 LELDLRGNKFGEEG 294
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1465-1777 |
5.78e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 54.17 E-value: 5.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1465 LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNsigdvgcchlsEALR 1544
Cdd:COG4886 42 LLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----------EELS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1545 AATSLEELDLSHNQIGDagvqhLATILPGLPELRKIDLSGNSISSaggvqlaeslvlcrrleelmlgcnalgdptalgla 1624
Cdd:COG4886 111 NLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTD----------------------------------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1625 qelpqhlrvLHLPFSHLgpggalslaqaldgsPHLEEISLAENNLAGgvlrfcmelpllrqidlvsckidnqtaklLTSS 1704
Cdd:COG4886 151 ---------LPEPLGNL---------------TNLKSLDLSNNQLTD-----------------------------LPEE 177
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864245113 1705 FTSCPALEVILLSWNLLGDeaaaeLAQVLPQMGRLKRVDLEKNQITALGawllaEGLAQGSSIQVIRLWNNPI 1777
Cdd:COG4886 178 LGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTDLP-----EPLANLTNLETLDLSNNQL 240
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1452-1645 |
2.37e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 52.24 E-value: 2.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1452 LAHLASGLGHCHHLEELDLSNNQFdeegtKALMRALEGKWMLKRLDLSHlllNS-STLAllthRLSQMTCLQSLRLNRNS 1530
Cdd:COG4886 194 ITDLPEPLGNLTNLEELDLSGNQL-----TDLPEPLANLTNLETLDLSN---NQlTDLP----ELGNLTNLEELDLSNNQ 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1531 IGDVGcchlseALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELML 1610
Cdd:COG4886 262 LTDLP------PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
|
170 180 190
....*....|....*....|....*....|....*
gi 1864245113 1611 GCNALGDPTALGLAQELPQHLRVLHLPFSHLGPGG 1645
Cdd:COG4886 336 TLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
704-911 |
4.67e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 51.09 E-value: 4.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 704 EALSRSLPTMGRLQMLGLAGSKITargisHLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSIc 783
Cdd:COG4886 126 TDLPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQI- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 784 vSTL-LCLARvavtCPTVRMLQAREADLifllsppTETTAELQRAPDLQesdgqrkgaqsrslTLRLQKCQLQVhdaeal 862
Cdd:COG4886 195 -TDLpEPLGN----LTNLEELDLSGNQL-------TDLPEPLANLTNLE--------------TLDLSNNQLTD------ 242
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1864245113 863 IALLQEGPHLEEVDLSGNQLEDegcrlmAEAASQLHIARKLDLSNNGLS 911
Cdd:COG4886 243 LPELGNLTNLEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLT 285
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1459-1636 |
1.91e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 47.86 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1459 LGHCHHLEELDLSNNQfdeegtkalmralegkwmLKRLDlshlllNSSTLALLTH------------RLSQMTCLQSLRL 1526
Cdd:cd21340 20 LSLCKNLKVLYLYDNK------------------ITKIE------NLEFLTNLTHlylqnnqiekieNLENLVNLKKLYL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1527 NRNSIGDVgcchlsEALRAATSLEELDLSHNQIgDAGVQHL---ATILPGLPELRKIDLSGNSISSaggvqlAESLVLCR 1603
Cdd:cd21340 76 GGNRISVV------EGLENLTNLEELHIENQRL-PPGEKLTfdpRSLAALSNSLRVLNISGNNIDS------LEPLAPLR 142
|
170 180 190
....*....|....*....|....*....|....
gi 1864245113 1604 RLEELMLGCNALGDPTAL-GLAQELPQhLRVLHL 1636
Cdd:cd21340 143 NLEQLDASNNQISDLEELlDLLSSWPS-LRELDL 175
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
716-911 |
3.15e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 48.39 E-value: 3.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 716 LQMLGLAGSKITargisHLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSICVstllcLARVAV 795
Cdd:COG4886 115 LESLDLSGNQLT-----DLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEELG 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 796 TCPTVRMLQAREADLifllsppTETTAELQRAPDLQEsdgqrkgaqsrsltLRLQKCQLQvhDAEALIALLqegPHLEEV 875
Cdd:COG4886 180 NLTNLKELDLSNNQI-------TDLPEPLGNLTNLEE--------------LDLSGNQLT--DLPEPLANL---TNLETL 233
|
170 180 190
....*....|....*....|....*....|....*.
gi 1864245113 876 DLSGNQLEDegcrlmAEAASQLHIARKLDLSNNGLS 911
Cdd:COG4886 234 DLSNNQLTD------LPELGNLTNLEELDLSNNQLT 263
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1493-1751 |
3.36e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 47.09 E-value: 3.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1493 LKRLdlSHLLLNSSTLALLtHRLSQMTCLQSLRLNRNSIGDVgcchlsEALRAATSLEELDLSHNQIgdagvqhlATI-- 1570
Cdd:cd21340 1 LKRI--THLYLNDKNITKI-DNLSLCKNLKVLYLYDNKITKI------ENLEFLTNLTHLYLQNNQI--------EKIen 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1571 LPGLPELRKIDLSGNSISSaggvqlAESLVLCRRLEELMLGCnalgdptalglaQELPQHLRVLHLPFSHLgpggalsla 1650
Cdd:cd21340 64 LENLVNLKKLYLGGNRISV------VEGLENLTNLEELHIEN------------QRLPPGEKLTFDPRSLA--------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1651 qaldgsphleeiSLAENnlaggvlrfcmelplLRQIDLVSCKIDNqtakllTSSFTSCPALEVILLSWNLLGDeaAAELA 1730
Cdd:cd21340 117 ------------ALSNS---------------LRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQISD--LEELL 161
|
250 260
....*....|....*....|.
gi 1864245113 1731 QVLPQMGRLKRVDLEKNQITA 1751
Cdd:cd21340 162 DLLSSWPSLRELDLTGNPVCK 182
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
649-782 |
1.60e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 46.08 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886 153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1864245113 729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1521-1587 |
1.91e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.97 E-value: 1.91e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245113 1521 LQSLRLNRNSIGDVGcchlSEALRAATSLEELDLSHNQIGdagvqhlaTILP----GLPELRKIDLSGNSI 1587
Cdd:pfam13855 3 LRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLLT--------TLSPgafsGLPSLRYLDLSGNRL 61
|
|
| LRR_6 |
pfam13516 |
Leucine Rich repeat; |
1547-1568 |
6.01e-04 |
|
Leucine Rich repeat;
Pssm-ID: 463907 [Multi-domain] Cd Length: 24 Bit Score: 38.76 E-value: 6.01e-04
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
1489-1588 |
1.34e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 43.65 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1489 GKWMLKRLDLShlllNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVgcchLSEALRAATSLEELDLSHNQIGDAgvqhLA 1568
Cdd:PLN03150 416 GKWFIDGLGLD----NQGLRGFIPNDISKLRHLQSINLSGNSIRGN----IPPSLGSITSLEVLDLSYNSFNGS----IP 483
|
90 100
....*....|....*....|
gi 1864245113 1569 TILPGLPELRKIDLSGNSIS 1588
Cdd:PLN03150 484 ESLGQLTSLRILNLNGNSLS 503
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
650-782 |
1.43e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 43.00 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 650 DLATLTNIlehreapIHLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITAr 729
Cdd:COG4886 131 ELANLTNL-------KELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD- 196
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1864245113 730 gishLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 197 ----LPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQL 240
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
1547-1585 |
2.91e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 37.22 E-value: 2.91e-03
10 20 30
....*....|....*....|....*....|....*....
gi 1864245113 1547 TSLEELDLSHNQIGDAGvqhlatILPGLPELRKIDLSGN 1585
Cdd:pfam12799 1 PNLEVLDLSNNQITDIP------PLAKLPNLETLDLSGN 33
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
680-772 |
3.09e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.08 E-value: 3.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 680 EALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALpLCPQLKEVSFRDNQLSDQVV 759
Cdd:COG5238 342 KALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQ 420
|
90
....*....|...
gi 1864245113 760 LNIVEVLPHLPRL 772
Cdd:COG5238 421 QRLEQLLERIKSV 433
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1465-1750 |
4.49e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 42.14 E-value: 4.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1465 LEELDLSNNQFDEE-----GTKALMRALE--GKWMLKRLDLShlLLNSSTLALLT-----------HRLSQMTCLQSLRL 1526
Cdd:PLN00113 142 LETLDLSNNMLSGEipndiGSFSSLKVLDlgGNVLVGKIPNS--LTNLTSLEFLTlasnqlvgqipRELGQMKSLKWIYL 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1527 NRNSIGDvgccHLSEALRAATSLEELDLSHNQIgdagvqhLATILPGLPELRKID---LSGNSISSaggvQLAESLVLCR 1603
Cdd:PLN00113 220 GYNNLSG----EIPYEIGGLTSLNHLDLVYNNL-------TGPIPSSLGNLKNLQylfLYQNKLSG----PIPPSIFSLQ 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1604 RLEELMLGCNALGDPTALGLAQElpQHLRVLHLPFSHLG---PGGALSLaqaldgsPHLEEISLAENNLAGGVLRFCMEL 1680
Cdd:PLN00113 285 KLISLDLSDNSLSGEIPELVIQL--QNLEILHLFSNNFTgkiPVALTSL-------PRLQVLQLWSNKFSGEIPKNLGKH 355
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1681 PLLRQIDLVSckiDNQTAKLLTSSFTSCPALEVILLSWNLLGdeaaaELAQVLPQMGRLKRVDLEKNQIT 1750
Cdd:PLN00113 356 NNLTVLDLST---NNLTGEIPEGLCSSGNLFKLILFSNSLEG-----EIPKSLGACRSLRRVRLQDNSFS 417
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1547-1568 |
5.49e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 35.85 E-value: 5.49e-03
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
705-783 |
6.62e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.15 E-value: 6.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 705 ALSRSLptmgrlQMLGLAGSKITA-RGISHLVkalplcpQLKEVSFRDNQLSDqvVLNIVEVLPHLPRLRKLDLSSNSIC 783
Cdd:cd21340 117 ALSNSL------RVLNISGNNIDSlEPLAPLR-------NLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVC 181
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1009-1373 |
7.05e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.80 E-value: 7.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1009 LDFSGNALGDEGAArlaQLLPGLGALQSLNLSENGLSLDAVLGLVRcfstlqwlfRLDISFESQHILLRGDKTSRDMWAT 1088
Cdd:cd00116 3 LSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLSLNETGRIPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1089 GSLPDfpaaakflGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDcpGPL-ELQLSCEFLSDQSLetlldclpqlpqlsl 1167
Cdd:cd00116 71 QSLLQ--------GLTKGCGLQELDLSDNALGPDGCGVLESLLRS--SSLqELKLNNNGLGDRGL--------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1168 lqlsqtglspksPFLLANTLSLCPRVKKVDLrslhhatlhfrsneeeegvccgfTGCSLSQEHVESLCWLLSKCKDLSQV 1247
Cdd:cd00116 126 ------------RLLAKGLKDLPPALEKLVL-----------------------GRNRLEGASCEALAKALRANRDLKEL 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245113 1248 DLG----SEQSFR--IHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSlvGRPAG 1321
Cdd:cd00116 171 NLAnngiGDAGIRalAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALAS--ALLSP 248
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1864245113 1322 LFSLrvqepwadraRVLSLLEVCAQASGSVTEisiSETQQQLCVQLEFPRQE 1373
Cdd:cd00116 249 NISL----------LTLSLSCNDITDDGAKDL---AEVLAEKESLLELDLRG 287
|
|
| |
