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Conserved domains on  [gi|1897358318|ref|NP_001373518|]
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SH2 domain-containing protein 3A isoform 8 [Homo sapiens]

Protein Classification

RasGEF domain-containing protein( domain architecture ID 940)

RasGEF domain-containing protein may function as a guanine nucleotide exchange factor for Ras-like small GTPases

CATH:  1.10.840.10
Gene Ontology:  GO:0005085|GO:0007264
PubMed:  10431174|7786285
SCOP:  4001268

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RasGEF super family cl02485
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
 110-261 9.01e-07

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


The actual alignment was detected with superfamily member cd00155:

Pssm-ID: 470590 [Multi-domain]  Cd Length: 237  Bit Score: 48.79  E-value: 9.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897358318 110 PLEERAAALRGLVELALALRpgAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRShteaALAFEQELKPLM--------- 180
Cdd:cd00155    70 NPKKRARLLSKFIQVAKHCR--ELNNFNSLMAIVSALSSSPISRLKKTWEVLSSK----LKKLFEELEELVdpsrnfkny 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897358318 181 -RALDEgagpCDPGEVALPHVAPMVRLLEGEEVAGP--LD------ESCERLLRTLHGARHMVRDAPKFRKVA--AQRLR 249
Cdd:cd00155   144 rKLLKS----VGPNPPCVPFLGVYLKDLTFLHEGNPdfLEgnlvnfEKRRKIAEILREIRQLQSNSYELNRDEdiLAFLW 219

                         170
                  ....*....|..
gi 1897358318 250 GFRPNPELREAL 261
Cdd:cd00155   220 KLLELILNEDEL 231
 
Name Accession Description Interval E-value
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
 110-261 9.01e-07

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087 [Multi-domain]  Cd Length: 237  Bit Score: 48.79  E-value: 9.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897358318 110 PLEERAAALRGLVELALALRpgAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRShteaALAFEQELKPLM--------- 180
Cdd:cd00155    70 NPKKRARLLSKFIQVAKHCR--ELNNFNSLMAIVSALSSSPISRLKKTWEVLSSK----LKKLFEELEELVdpsrnfkny 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897358318 181 -RALDEgagpCDPGEVALPHVAPMVRLLEGEEVAGP--LD------ESCERLLRTLHGARHMVRDAPKFRKVA--AQRLR 249
Cdd:cd00155   144 rKLLKS----VGPNPPCVPFLGVYLKDLTFLHEGNPdfLEgnlvnfEKRRKIAEILREIRQLQSNSYELNRDEdiLAFLW 219

                         170
                  ....*....|..
gi 1897358318 250 GFRPNPELREAL 261
Cdd:cd00155   220 KLLELILNEDEL 231
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
111-184 1.28e-06

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 48.40  E-value: 1.28e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1897358318  111 LEERAAALRGLVELALALRpgAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRShteaALAFEQELKPLMRALD 184
Cdd:smart00147  71 PKDRAELLSKFIQVAKHCR--ELNNFNSLMAIVSALSSSPISRLKKTWEKLPSK----YKKLFEELEELLSPER 138
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
 111-192 2.32e-04

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


Pssm-ID: 459872  Cd Length: 179  Bit Score: 41.04  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897358318 111 LEERAAALRGLVELALALRpgAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKP------LMRALD 184
Cdd:pfam00617  63 LKKRAKVIKKFIKIAEHCR--ELNNFNSLMAILSGLNSSPISRLKKTWELVSKKYKKTLEELEKLMSPsrnfknYREALS 140


                  ....*...
gi 1897358318 185 EGAGPCDP 192
Cdd:pfam00617 141 SASPPCIP 148
 
Name Accession Description Interval E-value
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
 110-261 9.01e-07

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087 [Multi-domain]  Cd Length: 237  Bit Score: 48.79  E-value: 9.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897358318 110 PLEERAAALRGLVELALALRpgAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRShteaALAFEQELKPLM--------- 180
Cdd:cd00155    70 NPKKRARLLSKFIQVAKHCR--ELNNFNSLMAIVSALSSSPISRLKKTWEVLSSK----LKKLFEELEELVdpsrnfkny 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897358318 181 -RALDEgagpCDPGEVALPHVAPMVRLLEGEEVAGP--LD------ESCERLLRTLHGARHMVRDAPKFRKVA--AQRLR 249
Cdd:cd00155   144 rKLLKS----VGPNPPCVPFLGVYLKDLTFLHEGNPdfLEgnlvnfEKRRKIAEILREIRQLQSNSYELNRDEdiLAFLW 219

                         170
                  ....*....|..
gi 1897358318 250 GFRPNPELREAL 261
Cdd:cd00155   220 KLLELILNEDEL 231
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
111-184 1.28e-06

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 48.40  E-value: 1.28e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1897358318  111 LEERAAALRGLVELALALRpgAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRShteaALAFEQELKPLMRALD 184
Cdd:smart00147  71 PKDRAELLSKFIQVAKHCR--ELNNFNSLMAIVSALSSSPISRLKKTWEKLPSK----YKKLFEELEELLSPER 138
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
 111-192 2.32e-04

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


Pssm-ID: 459872  Cd Length: 179  Bit Score: 41.04  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1897358318 111 LEERAAALRGLVELALALRpgAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKP------LMRALD 184
Cdd:pfam00617  63 LKKRAKVIKKFIKIAEHCR--ELNNFNSLMAILSGLNSSPISRLKKTWELVSKKYKKTLEELEKLMSPsrnfknYREALS 140


                  ....*...
gi 1897358318 185 EGAGPCDP 192
Cdd:pfam00617 141 SASPPCIP 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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