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Conserved domains on  [gi|1905532690|ref|NP_001373931|]
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NEDD4-binding protein 2-like 2 isoform 4 [Homo sapiens]

Protein Classification

ATP-binding protein( domain architecture ID 12153064)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain may function as an ATPase; similar to NEDD4-binding protein 2-like 1/2 (N4BP2L1 and N4BP2L2), whose functions are not clear

Gene Ontology:  GO:0005524
PubMed:  15037234|18208389

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 404-536 1.59e-19

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


:

Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 86.21  E-value: 1.59e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690  404 LILLRGLPGSGKTTLSRILLGQNrDGIVFSTDDYF-----HHQDGYRYNVNQLGDAHDWNQNRAKQAIDQGRsPVIIDNT 478
Cdd:pfam13671    1 LILLVGLPGSGKSTLARRLLEEL-GAVRLSSDDERkrlfgEGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDAT 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1905532690  479 NIQAWEMKPYVEVAIGKGYRVEFHEPETwwkfDPEELEKRNK---------HGVSRKKIAQMLDRYE 536
Cdd:pfam13671   79 NLRRDERARLLALAREYGVPVRIVVFEA----PEEVLRERLAararaggdpSDVPEEVLDRQKARFE 141
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 404-536 1.59e-19

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 86.21  E-value: 1.59e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690  404 LILLRGLPGSGKTTLSRILLGQNrDGIVFSTDDYF-----HHQDGYRYNVNQLGDAHDWNQNRAKQAIDQGRsPVIIDNT 478
Cdd:pfam13671    1 LILLVGLPGSGKSTLARRLLEEL-GAVRLSSDDERkrlfgEGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDAT 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1905532690  479 NIQAWEMKPYVEVAIGKGYRVEFHEPETwwkfDPEELEKRNK---------HGVSRKKIAQMLDRYE 536
Cdd:pfam13671   79 NLRRDERARLLALAREYGVPVRIVVFEA----PEEVLRERLAararaggdpSDVPEEVLDRQKARFE 141
COG4639 COG4639
Predicted kinase [General function prediction only];
404-536 3.69e-16

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 76.41  E-value: 3.69e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690  404 LILLRGLPGSGKTTLSRILLgqnRDGIVFSTDDyFHHQ--DGYRYNVNQlGDAHDWNQNRAKQAIDQGRsPVIIDNTNIQ 481
Cdd:COG4639      4 LVVLIGLPGSGKSTFARRLF---APTEVVSSDD-IRALlgGDENDQSAW-GDVFQLAHEIARARLRAGR-LTVVDATNLQ 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1905532690  482 AWEMKPYVEVAIGKGYRVE---FHEPEtwwkfdpEELEKRNK---HGVSRKKIAQMLDRYE 536
Cdd:COG4639     78 REARRRLLALARAYGALVVavvLDVPL-------EVCLARNAardRQVPEEVIRRMLRRLR 131
pseT PHA02530
polynucleotide kinase; Provisional
 404-520 8.48e-10

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 61.58  E-value: 8.48e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690  404 LILLRGLPGSGKTTLSRILLGQNRDGIVFSTDDY----FHHQ--DGYRYNVNQLGDAHDWNQNRAKQAIDQGRSpVIIDN 477
Cdd:PHA02530     4 IILTVGVPGSGKSTWAREFAAKNPKAVNVNRDDLrqslFGHGewGEYKFTKEKEDLVTKAQEAAALAALKSGKS-VIISD 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1905532690  478 TNIQAWEMKPYVEVAigKGYRVEFHepETWWKFDPEELEKRNK 520
Cdd:PHA02530    83 TNLNPERRRKWKELA--KELGAEFE--EKVFDVPVEELVKRNR 121
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 405-477 4.56e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.89  E-value: 4.56e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690   405 ILLRGLPGSGKTTLSRILLGQ----NRDGIVFSTDDYFHHQDGYRYNVNQLGDAHDWNQ-NRAKQAIDQGRSP----VII 475
Cdd:smart00382    5 ILIVGPPGSGKTTLARALARElgppGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGeLRLRLALALARKLkpdvLIL 84


                    ..
gi 1905532690   476 DN 477
Cdd:smart00382   85 DE 86
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 404-536 1.59e-19

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 86.21  E-value: 1.59e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690  404 LILLRGLPGSGKTTLSRILLGQNrDGIVFSTDDYF-----HHQDGYRYNVNQLGDAHDWNQNRAKQAIDQGRsPVIIDNT 478
Cdd:pfam13671    1 LILLVGLPGSGKSTLARRLLEEL-GAVRLSSDDERkrlfgEGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDAT 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1905532690  479 NIQAWEMKPYVEVAIGKGYRVEFHEPETwwkfDPEELEKRNK---------HGVSRKKIAQMLDRYE 536
Cdd:pfam13671   79 NLRRDERARLLALAREYGVPVRIVVFEA----PEEVLRERLAararaggdpSDVPEEVLDRQKARFE 141
COG4639 COG4639
Predicted kinase [General function prediction only];
404-536 3.69e-16

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 76.41  E-value: 3.69e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690  404 LILLRGLPGSGKTTLSRILLgqnRDGIVFSTDDyFHHQ--DGYRYNVNQlGDAHDWNQNRAKQAIDQGRsPVIIDNTNIQ 481
Cdd:COG4639      4 LVVLIGLPGSGKSTFARRLF---APTEVVSSDD-IRALlgGDENDQSAW-GDVFQLAHEIARARLRAGR-LTVVDATNLQ 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1905532690  482 AWEMKPYVEVAIGKGYRVE---FHEPEtwwkfdpEELEKRNK---HGVSRKKIAQMLDRYE 536
Cdd:COG4639     78 REARRRLLALARAYGALVVavvLDVPL-------EVCLARNAardRQVPEEVIRRMLRRLR 131
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
404-518 2.85e-11

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 63.01  E-value: 2.85e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690  404 LILLRGLPGSGKTTLSRIlLGQNRDGIVFSTD--------DYFHHQDGYRyNVNQLGDAHDWnqNRAKQAIDQGRSpVII 475
Cdd:COG0645      1 LILVCGLPGSGKSTLARA-LAERLGAVRLRSDvvrkrlfgAGLAPLERSP-EATARTYARLL--ALARELLAAGRS-VIL 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1905532690  476 DNTNIQAWEMKPYVEVAIGKGYRVEFHEPETwwkfDPEELEKR 518
Cdd:COG0645     76 DATFLRRAQREAFRALAEEAGAPFVLIWLDA----PEEVLRER 114
pseT PHA02530
polynucleotide kinase; Provisional
 404-520 8.48e-10

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 61.58  E-value: 8.48e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690  404 LILLRGLPGSGKTTLSRILLGQNRDGIVFSTDDY----FHHQ--DGYRYNVNQLGDAHDWNQNRAKQAIDQGRSpVIIDN 477
Cdd:PHA02530     4 IILTVGVPGSGKSTWAREFAAKNPKAVNVNRDDLrqslFGHGewGEYKFTKEKEDLVTKAQEAAALAALKSGKS-VIISD 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1905532690  478 TNIQAWEMKPYVEVAigKGYRVEFHepETWWKFDPEELEKRNK 520
Cdd:PHA02530    83 TNLNPERRRKWKELA--KELGAEFE--EKVFDVPVEELVKRNR 121
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 404-483 1.78e-06

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 49.73  E-value: 1.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690  404 LILLRGLPGSGKTTLSRILLGQ----NRDGIVFSTDDYFHHQdgyrYNVNQLGDAH-----DWNQNRAKQAIDQGRSpVI 474
Cdd:COG4088      6 LLILTGPPGSGKTTFAKALAQRlyaeGIAVALLHSDDFRRFL----VNESFPKETYeevveDVRTTTADNALDNGYS-VI 80


                   ....*....
gi 1905532690  475 IDNTNIQAW 483
Cdd:COG4088     81 VDGTFYYRS 89
Zeta_toxin pfam06414
Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is ...
 401-510 1.46e-05

Zeta toxin; This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid.


Pssm-ID: 428926  Cd Length: 192  Bit Score: 46.97  E-value: 1.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690  401 QKLLILLRGLPGSGKTTLSRIL---LGQNRDGIVFSTDDY--FH-------HQDGYRYNVNQLGDAHDWNQNRAKQAIDQ 468
Cdd:pfam06414   10 RPKAILLGGQPGAGKTELARALldeLGRQGNVVRIDPDDFreLHphyrelqAADPKTASEYTQPDASRWVEKLLQHAIEN 89

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1905532690  469 GRSpVIIDNTNIQAWEMKPYVEVAIGKGYRVEFH----EPETWWKF 510
Cdd:pfam06414   90 GYN-IILEGTLRSPDVAKKIARALKAAGYRVEVAavaaPPELSWLG 134
KTI12 pfam08433
Chromatin associated protein KTI12; This is a family of chromatin associated proteins which ...
 404-536 2.79e-05

Chromatin associated protein KTI12; This is a family of chromatin associated proteins which interact with the Elongator complex, a component of the elongating form of RNA polymerase II. The Elongator complex has histone acetyltransferase activity.


Pssm-ID: 400643  Cd Length: 269  Bit Score: 47.29  E-value: 2.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690  404 LILLRGLPGSGKTT----LSRILLGQNRDGIVFSTDDYFHHQDGYRyNVNQLGDAHDWNQNRAKQAIDQGRSpVIIDNTN 479
Cdd:pfam08433    1 LVLLTGLPSSGKSTrakqLAKYLEESNYDVIVISDESLGIEKDDYK-DSAKEKFLRGSLRSAVKRDLSKNTI-VIVDSLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1905532690  480 iqawemkpYVevaigKGYRVEFH-----------------EPETWWKFDPEELEkrnKHGVSRKKIAQMLDRYE 536
Cdd:pfam08433   79 --------YI-----KGFRYELYciakaarttycvihckaPLDLCRKWNEERGQ---KSRYPDELLDALIQRYE 136
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 403-457 5.69e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 42.52  E-value: 5.69e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1905532690  403 LLILLRGLPGSGKTTLSR---ILLGQNRdGIVFSTDDYFHHQDGY----RYNVNQLG-DAHDW 457
Cdd:COG0572      8 RIIGIAGPSGSGKTTFARrlaEQLGADK-VVVISLDDYYKDREHLpldeRGKPNFDHpEAFDL 69
AAA_18 pfam13238
AAA domain;
405-528 6.69e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 40.87  E-value: 6.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690  405 ILLRGLPGSGKTTLSRILlgQNRDGIVFSTDDYFHHQDGYRYNVNQLG-------DAHDWNQNRAKQAIDQGR-SPVIID 476
Cdd:pfam13238    1 ILITGTPGVGKTTLAKEL--SKRLGFGDNVRDLALENGLVLGDDPETReskrldeDKLDRLLDLLEENAALEEgGNLIID 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1905532690  477 NTNIQ--AWEMKPYVEVAIgkgyRVefhepetwwkfDPEELEKRNKH-GVSRKKI 528
Cdd:pfam13238   79 GHLAElePERAKDLVGIVL----RA-----------SPEELLERLEKrGYEEAKI 118
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 405-477 4.56e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.89  E-value: 4.56e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532690   405 ILLRGLPGSGKTTLSRILLGQ----NRDGIVFSTDDYFHHQDGYRYNVNQLGDAHDWNQ-NRAKQAIDQGRSP----VII 475
Cdd:smart00382    5 ILIVGPPGSGKTTLARALARElgppGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGeLRLRLALALARKLkpdvLIL 84


                    ..
gi 1905532690   476 DN 477
Cdd:smart00382   85 DE 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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