DEP domain-containing protein 4 isoform 7 [Homo sapiens]
Rho GTPase-activating protein( domain architecture ID 10138380)
Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
RhoGAP_BRCC3-like | cd04405 | RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ... |
233-462 | 1.57e-60 | ||||
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. : Pssm-ID: 239870 Cd Length: 235 Bit Score: 198.32 E-value: 1.57e-60
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DEP_DEPDC4 | cd04446 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a ... |
64-159 | 3.46e-43 | ||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function. : Pssm-ID: 239893 Cd Length: 95 Bit Score: 147.89 E-value: 3.46e-43
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Name | Accession | Description | Interval | E-value | ||||
RhoGAP_BRCC3-like | cd04405 | RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ... |
233-462 | 1.57e-60 | ||||
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. Pssm-ID: 239870 Cd Length: 235 Bit Score: 198.32 E-value: 1.57e-60
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DEP_DEPDC4 | cd04446 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a ... |
64-159 | 3.46e-43 | ||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function. Pssm-ID: 239893 Cd Length: 95 Bit Score: 147.89 E-value: 3.46e-43
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DEP | pfam00610 | Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ... |
75-160 | 3.14e-14 | ||||
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit. Pssm-ID: 459867 Cd Length: 71 Bit Score: 67.23 E-value: 3.14e-14
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DEP | smart00049 | Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ... |
75-136 | 9.21e-11 | ||||
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118). Pssm-ID: 214489 Cd Length: 77 Bit Score: 57.68 E-value: 9.21e-11
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Name | Accession | Description | Interval | E-value | ||||
RhoGAP_BRCC3-like | cd04405 | RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ... |
233-462 | 1.57e-60 | ||||
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. Pssm-ID: 239870 Cd Length: 235 Bit Score: 198.32 E-value: 1.57e-60
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DEP_DEPDC4 | cd04446 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a ... |
64-159 | 3.46e-43 | ||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function. Pssm-ID: 239893 Cd Length: 95 Bit Score: 147.89 E-value: 3.46e-43
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DEP | pfam00610 | Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ... |
75-160 | 3.14e-14 | ||||
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit. Pssm-ID: 459867 Cd Length: 71 Bit Score: 67.23 E-value: 3.14e-14
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DEP | cd04371 | DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ... |
62-137 | 3.80e-14 | ||||
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction. Pssm-ID: 239836 Cd Length: 81 Bit Score: 67.37 E-value: 3.80e-14
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DEP | smart00049 | Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ... |
75-136 | 9.21e-11 | ||||
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118). Pssm-ID: 214489 Cd Length: 77 Bit Score: 57.68 E-value: 9.21e-11
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DEP_BRCC3 | cd04447 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also ... |
62-160 | 4.95e-04 | ||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function. Pssm-ID: 239894 Cd Length: 92 Bit Score: 39.06 E-value: 4.95e-04
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DEP_1_DEP6 | cd04442 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins ... |
77-103 | 9.45e-04 | ||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown. Pssm-ID: 239889 [Multi-domain] Cd Length: 82 Bit Score: 37.95 E-value: 9.45e-04
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DEP_2_P-Rex | cd04440 | DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex ... |
68-134 | 3.12e-03 | ||||
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF activity is stimulated by phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3), a lipid second messenger, and the G beta-gamma subunits of heterotrimeric G proteins. The DEP domains are not involved in mediating these stimuli, but may be of importance for basal and stimulated levels Rac-GEF activity. Pssm-ID: 239887 Cd Length: 93 Bit Score: 36.83 E-value: 3.12e-03
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