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Conserved domains on  [gi|1908918796|ref|NP_001374141|]
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DEP domain-containing protein 4 isoform 11 [Homo sapiens]

Protein Classification

RhoGAP_BRCC3-like domain-containing protein( domain architecture ID 10138287)

RhoGAP_BRCC3-like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 58-286 1.75e-61

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239870  Cd Length: 235  Bit Score: 195.24  E-value: 1.75e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918796  58 DVWKEQTLLCLLQLIHLPFLDNILEP-PVKTQNLQLNKEEDlVITNTCLDRELIPSLCLPEIDNWLNAAIECLEYFPDQL 136
Cdd:cd04405     8 EIWKEQTLIRLLQLVGLPLLEELLDPaLVNPKHISYNMDPD-VYTSNYLDREVVKLFSKSQLDHWLLSAMDCLANWPDQL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918796 137 IVTVSQQLMQnrnEETRLNSQKKILFDVIAKYYAQERDCLLTDEYFDIHSGIIELLENEKRAEALEATQLYLRLLLLNIR 216
Cdd:cd04405    87 VVDVSRPLYS---QHDMLSGFKRLLFKTIAKYYGQLKEPLLTFHLFDIFVGILELLGNGKEEVALEALQLCLLLLPPASR 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918796 217 EELRRLLTFMAMASEPNAYKLQKQYDNKTVVLKTLAKSVLQAKSLLKVRAEQLVWFPLEYHSELFKVSLA 286
Cdd:cd04405   164 RELRRLLRFMARAAKNDMPRLHKEIENRMLVKQTFSRAILCSKDLDEGLADLLVLFLMDHHQDIFKVPGS 233
 
Name Accession Description Interval E-value
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 58-286 1.75e-61

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 195.24  E-value: 1.75e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918796  58 DVWKEQTLLCLLQLIHLPFLDNILEP-PVKTQNLQLNKEEDlVITNTCLDRELIPSLCLPEIDNWLNAAIECLEYFPDQL 136
Cdd:cd04405     8 EIWKEQTLIRLLQLVGLPLLEELLDPaLVNPKHISYNMDPD-VYTSNYLDREVVKLFSKSQLDHWLLSAMDCLANWPDQL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918796 137 IVTVSQQLMQnrnEETRLNSQKKILFDVIAKYYAQERDCLLTDEYFDIHSGIIELLENEKRAEALEATQLYLRLLLLNIR 216
Cdd:cd04405    87 VVDVSRPLYS---QHDMLSGFKRLLFKTIAKYYGQLKEPLLTFHLFDIFVGILELLGNGKEEVALEALQLCLLLLPPASR 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918796 217 EELRRLLTFMAMASEPNAYKLQKQYDNKTVVLKTLAKSVLQAKSLLKVRAEQLVWFPLEYHSELFKVSLA 286
Cdd:cd04405   164 RELRRLLRFMARAAKNDMPRLHKEIENRMLVKQTFSRAILCSKDLDEGLADLLVLFLMDHHQDIFKVPGS 233
 
Name Accession Description Interval E-value
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 58-286 1.75e-61

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 195.24  E-value: 1.75e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918796  58 DVWKEQTLLCLLQLIHLPFLDNILEP-PVKTQNLQLNKEEDlVITNTCLDRELIPSLCLPEIDNWLNAAIECLEYFPDQL 136
Cdd:cd04405     8 EIWKEQTLIRLLQLVGLPLLEELLDPaLVNPKHISYNMDPD-VYTSNYLDREVVKLFSKSQLDHWLLSAMDCLANWPDQL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918796 137 IVTVSQQLMQnrnEETRLNSQKKILFDVIAKYYAQERDCLLTDEYFDIHSGIIELLENEKRAEALEATQLYLRLLLLNIR 216
Cdd:cd04405    87 VVDVSRPLYS---QHDMLSGFKRLLFKTIAKYYGQLKEPLLTFHLFDIFVGILELLGNGKEEVALEALQLCLLLLPPASR 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918796 217 EELRRLLTFMAMASEPNAYKLQKQYDNKTVVLKTLAKSVLQAKSLLKVRAEQLVWFPLEYHSELFKVSLA 286
Cdd:cd04405   164 RELRRLLRFMARAAKNDMPRLHKEIENRMLVKQTFSRAILCSKDLDEGLADLLVLFLMDHHQDIFKVPGS 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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