NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1910601180|ref|NP_001374204|]
View 

doublecortin domain-containing protein 1 isoform 7 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_Ricin-like super family cl49609
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ...
 82-185 7.25e-47

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.


The actual alignment was detected with superfamily member cd23427:

Pssm-ID: 483949  Cd Length: 146  Bit Score: 162.86  E-value: 7.25e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  82 HQQFEYRDGQIISHAAPQLVLGVQGPNLRSGMEVVLVEKKSDGSHQRWIHQEDsrtFHLVSNP--DLVLAVSMTKTRNE- 158
Cdd:cd23427    37 LQQFVFEDGFISCCSNPNLVLGVQGSELGRGAEVVLVKKKPDDINQRWILRED---GHIMSKPnyDLVLTVSMPSTTPGd 113

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1910601180 159 ------VCGYPVIVQKYKPYNNGAANQKWHYMK 185
Cdd:cd23427   114 sssplsYIGCAVILQKYKGYSYGRANQKWHWDP 146
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 585-657 6.77e-41

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


:

Pssm-ID: 340679  Cd Length: 73  Bit Score: 143.59  E-value: 6.77e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1910601180 585 KRVWIYLNGGRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFKT 657
Cdd:cd17159     1 KRVLVYPNGGSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGEPFLT 73
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 330-467 1.69e-28

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


:

Pssm-ID: 340678  Cd Length: 73  Bit Score: 108.55  E-value: 1.69e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180 330 VKIIAYKNGDGY-RNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIftlrdlvlwaldesflqrdsekqkqdaa 408
Cdd:cd17158     1 VKILAYKNGEGRlRDGVLIIGSTFPGLLDQCTHRLGLARAARRLYTADGTLI---------------------------- 52

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1910601180 409 pvgkeqiiveknprmkvknrlfaksvtsdsldgidkslLTLILRNPIAIWVSCGEPFLP 467
Cdd:cd17158    53 --------------------------------------LTLILRYPIEVWVSCGEPFIP 73
 
Name Accession Description Interval E-value
beta-trefoil_Ricin_DCDC1 cd23427
ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein ...
 82-185 7.25e-47

ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein 1 (DCDC1) and similar proteins; DCDC1, also called doublecortin domain-containing 5 protein (DCDC5), is a microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. In addition to doublecortin-like domains, DCDC1 may also contain a ricin B-type lectin domain in the middle region. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a putative sugar-binding pocket.


Pssm-ID: 467305  Cd Length: 146  Bit Score: 162.86  E-value: 7.25e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  82 HQQFEYRDGQIISHAAPQLVLGVQGPNLRSGMEVVLVEKKSDGSHQRWIHQEDsrtFHLVSNP--DLVLAVSMTKTRNE- 158
Cdd:cd23427    37 LQQFVFEDGFISCCSNPNLVLGVQGSELGRGAEVVLVKKKPDDINQRWILRED---GHIMSKPnyDLVLTVSMPSTTPGd 113

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1910601180 159 ------VCGYPVIVQKYKPYNNGAANQKWHYMK 185
Cdd:cd23427   114 sssplsYIGCAVILQKYKGYSYGRANQKWHWDP 146
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 585-657 6.77e-41

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340679  Cd Length: 73  Bit Score: 143.59  E-value: 6.77e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1910601180 585 KRVWIYLNGGRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFKT 657
Cdd:cd17159     1 KRVLVYPNGGSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGEPFLT 73
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 330-467 1.69e-28

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340678  Cd Length: 73  Bit Score: 108.55  E-value: 1.69e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180 330 VKIIAYKNGDGY-RNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIftlrdlvlwaldesflqrdsekqkqdaa 408
Cdd:cd17158     1 VKILAYKNGEGRlRDGVLIIGSTFPGLLDQCTHRLGLARAARRLYTADGTLI---------------------------- 52

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1910601180 409 pvgkeqiiveknprmkvknrlfaksvtsdsldgidkslLTLILRNPIAIWVSCGEPFLP 467
Cdd:cd17158    53 --------------------------------------LTLILRYPIEVWVSCGEPFIP 73
Ricin_B_lectin pfam00652
Ricin-type beta-trefoil lectin domain;
80-181 2.00e-06

Ricin-type beta-trefoil lectin domain;


Pssm-ID: 395527 [Multi-domain]  Cd Length: 126  Bit Score: 47.53  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  80 HCH-----QQFEYRDGQIISHAAPQLVLGVQGPNlrSGMEVVLVEKKSDGSHQRWIHQEDSRT-FHLVSNpdLVLAVSMT 153
Cdd:pfam00652  30 PCHgsngnQLWTLTGDGTIRSVASDLCLDVGSTA--DGAKVVLWPCHPGNGNQRWRYDEDGTQiRNPQSG--KCLDVSGA 105

                          90       100
                  ....*....|....*....|....*...
gi 1910601180 154 KTRNEvcgyPVIVQKYkpyNNGAANQKW 181
Cdd:pfam00652 106 GTSNG----KVILWTC---DSGNPNQQW 126
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 325-387 2.28e-05

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 43.40  E-value: 2.28e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  325 THQKAVKIIAYKNGDGYRNG-KLIV----AGTFPMLLTECTEQLGL--ARAASKVYTKDGTPIFTLRDLV 387
Cdd:smart00537   1 SLVKPKRIRFYRNGDRFFKGvRLVVnrkrFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELE 70
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 581-659 9.32e-05

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 41.47  E-value: 9.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  581 QPNTKRVWIYLNGGRPEDG-----TYAWGKTISELLQDCSSRLKM--THPARALYTPSGEPIQSWDDIERDMVICVSMGH 653
Cdd:smart00537   2 LVKPKRIRFYRNGDRFFKGvrlvvNRKRFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTE 81


                   ....*.
gi 1910601180  654 GFKTPK 659
Cdd:smart00537  82 AFKKVD 87
RICIN smart00458
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.
 81-181 2.13e-04

Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.


Pssm-ID: 214672 [Multi-domain]  Cd Length: 118  Bit Score: 41.34  E-value: 2.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180   81 CH-----QQFEYRDGQIISHAAPQLVLGVQGPNlrsGMEVVLVEKKSDGSHQRWIHQEDSRTFHLVSNpdLVLAVSMTKT 155
Cdd:smart00458  24 CHgtggnQLWKLTSDGAIRIKDTDLCLTANGNT---GSTVTLYSCDGTNDNQYWEVNKDGTIRNPDSG--KCLDVKDGNT 98

                           90       100
                   ....*....|....*....|....*.
gi 1910601180  156 RNEVCGYPvivqkykpyNNGAANQKW 181
Cdd:smart00458  99 GTKVILWT---------CSGNPNQKW 115
 
Name Accession Description Interval E-value
beta-trefoil_Ricin_DCDC1 cd23427
ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein ...
 82-185 7.25e-47

ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein 1 (DCDC1) and similar proteins; DCDC1, also called doublecortin domain-containing 5 protein (DCDC5), is a microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. In addition to doublecortin-like domains, DCDC1 may also contain a ricin B-type lectin domain in the middle region. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a putative sugar-binding pocket.


Pssm-ID: 467305  Cd Length: 146  Bit Score: 162.86  E-value: 7.25e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  82 HQQFEYRDGQIISHAAPQLVLGVQGPNLRSGMEVVLVEKKSDGSHQRWIHQEDsrtFHLVSNP--DLVLAVSMTKTRNE- 158
Cdd:cd23427    37 LQQFVFEDGFISCCSNPNLVLGVQGSELGRGAEVVLVKKKPDDINQRWILRED---GHIMSKPnyDLVLTVSMPSTTPGd 113

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1910601180 159 ------VCGYPVIVQKYKPYNNGAANQKWHYMK 185
Cdd:cd23427   114 sssplsYIGCAVILQKYKGYSYGRANQKWHWDP 146
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 585-657 6.77e-41

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340679  Cd Length: 73  Bit Score: 143.59  E-value: 6.77e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1910601180 585 KRVWIYLNGGRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFKT 657
Cdd:cd17159     1 KRVLVYPNGGSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGEPFLT 73
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 330-467 1.69e-28

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340678  Cd Length: 73  Bit Score: 108.55  E-value: 1.69e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180 330 VKIIAYKNGDGY-RNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIftlrdlvlwaldesflqrdsekqkqdaa 408
Cdd:cd17158     1 VKILAYKNGEGRlRDGVLIIGSTFPGLLDQCTHRLGLARAARRLYTADGTLI---------------------------- 52

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1910601180 409 pvgkeqiiveknprmkvknrlfaksvtsdsldgidkslLTLILRNPIAIWVSCGEPFLP 467
Cdd:cd17158    53 --------------------------------------LTLILRYPIEVWVSCGEPFIP 73
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
 585-652 2.62e-24

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 96.57  E-value: 2.62e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1910601180 585 KRVWIYLNGGR-PEDGTYAWGK--TISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMG 652
Cdd:cd17072     1 VRLRVLKNGERdLERAVYVVGPdlELQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
 330-386 6.04e-17

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 75.77  E-value: 6.04e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180 330 VKIIAYKNGDG-YRNGKLIVAG--TFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDL 386
Cdd:cd17072     1 VRLRVLKNGERdLERAVYVVGPdlELQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDL 60
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 585-651 5.19e-16

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 73.03  E-value: 5.19e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1910601180 585 KRVWIYLNGGRPEDGTYAWGK-----TISELLQDCSSRLKM-THPARALYTPSGEPIQSWDDIERDMVICVSM 651
Cdd:cd01617     1 KRITVFRNGDKNFKGVKVLVKprrfrTFDQLLDELTEKLGLpTGGVRKLYTPSGKLVKSLSDLEDGESYVVCG 73
beta-trefoil_Ricin_GllA-1 cd23454
GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; ...
 82-181 2.40e-10

GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.


Pssm-ID: 467332 [Multi-domain]  Cd Length: 136  Bit Score: 58.87  E-value: 2.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  82 HQQFEYRDGQIIsHAAPQLVLGVQGPNLRSGMEVVLVEKKS--DGSHQRWIHQEDSrTFHLVSNPDLVLAVSMTKTRNev 159
Cdd:cd23454    39 SQLWRYDDGYLV-NKASGLVLDIQGGVVKSGTRLVQSPKKPskDANNQRWGLTADG-YIYLLSNPSLVLGIKGNETRE-- 114

                          90       100
                  ....*....|....*....|..
gi 1910601180 160 cGYPVIVQKYKPYNNgAANQKW 181
Cdd:cd23454   115 -GARVILQERKLQKD-ALNQRW 134
DCX_DCDC1 cd17155
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ...
 330-386 6.47e-10

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340675  Cd Length: 72  Bit Score: 55.86  E-value: 6.47e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1910601180 330 VKIIAYKNGDGYRNGKlIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDL 386
Cdd:cd17155     1 IKVTAFKNGTRDVFAK-VTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDI 56
DCX1_DCDC5 cd17156
Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 330-386 1.49e-08

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340676  Cd Length: 76  Bit Score: 51.91  E-value: 1.49e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1910601180 330 VKIIAYKNGDGYRNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDL 386
Cdd:cd17156     1 LRLRVLRNGEKDKNKAVTVVGEFQLFLERCTTALNLPFAARRLFDEKGKEHFTLKDL 57
beta-trefoil_Ricin-like cd00161
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ...
 82-181 1.62e-08

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.


Pssm-ID: 467293 [Multi-domain]  Cd Length: 134  Bit Score: 53.53  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  82 HQQFEYRD-----GQIIShAAPQLVLGVQGPNLRSGMEVVLVEkKSDGSHQRW-IHQEDSRTFHLVS-NPDLVLAVSMTK 154
Cdd:cd00161    37 NQQWTLTPvgdgyYTIRN-VASGKCLDVAGGSTANGANVQQWT-CNGGDNQQWrLEPVGDGYYRIVNkHSGKCLDVSGGS 114

                          90       100
                  ....*....|....*....|....*..
gi 1910601180 155 TRNevcGYPVIVQKYkpynNGAANQKW 181
Cdd:cd00161   115 TAN---GANVQQWTC----NGGANQQW 134
DCX3_DCDC5 cd17158
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 586-635 4.47e-08

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340678  Cd Length: 73  Bit Score: 50.39  E-value: 4.47e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1910601180 586 RVWIYLNG-GRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPI 635
Cdd:cd17158     2 KILAYKNGeGRLRDGVLIIGSTFPGLLDQCTHRLGLARAARRLYTADGTLI 52
DCX_DCDC1 cd17155
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ...
 586-656 1.88e-06

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340675  Cd Length: 72  Bit Score: 45.84  E-value: 1.88e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1910601180 586 RVWIYLNGGRPedgTYA--WGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFK 656
Cdd:cd17155     2 KVTAFKNGTRD---VFAkvTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGEPFK 71
Ricin_B_lectin pfam00652
Ricin-type beta-trefoil lectin domain;
80-181 2.00e-06

Ricin-type beta-trefoil lectin domain;


Pssm-ID: 395527 [Multi-domain]  Cd Length: 126  Bit Score: 47.53  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  80 HCH-----QQFEYRDGQIISHAAPQLVLGVQGPNlrSGMEVVLVEKKSDGSHQRWIHQEDSRT-FHLVSNpdLVLAVSMT 153
Cdd:pfam00652  30 PCHgsngnQLWTLTGDGTIRSVASDLCLDVGSTA--DGAKVVLWPCHPGNGNQRWRYDEDGTQiRNPQSG--KCLDVSGA 105

                          90       100
                  ....*....|....*....|....*...
gi 1910601180 154 KTRNEvcgyPVIVQKYkpyNNGAANQKW 181
Cdd:pfam00652 106 GTSNG----KVILWTC---DSGNPNQQW 126
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 330-387 4.63e-06

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 44.91  E-value: 4.63e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1910601180 330 VKIIAYKNGDGYRNGKLIV-----AGTFPMLLTECTEQLGL-ARAASKVYTKDGTPIFTLRDLV 387
Cdd:cd01617     1 KRITVFRNGDKNFKGVKVLvkprrFRTFDQLLDELTEKLGLpTGGVRKLYTPSGKLVKSLSDLE 64
beta-trefoil_Ricin-like cd00161
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ...
 93-183 7.39e-06

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.


Pssm-ID: 467293 [Multi-domain]  Cd Length: 134  Bit Score: 45.82  E-value: 7.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  93 ISHAAPQLVLGVQGPNLRSGMEVVLVEKkSDGSHQRW-IHQEDSRTFHLVS-NPDLVLAVSMTKTRNevcGYPVIVQKYk 170
Cdd:cd00161     5 IVNAASGKCLDVAGGSTANGAPVQQWTC-NGGANQQWtLTPVGDGYYTIRNvASGKCLDVAGGSTAN---GANVQQWTC- 79

                          90
                  ....*....|...
gi 1910601180 171 pynNGAANQKWHY 183
Cdd:cd00161    80 ---NGGDNQQWRL 89
DCX4_DCDC5 cd17159
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 331-386 9.88e-06

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340679  Cd Length: 73  Bit Score: 43.82  E-value: 9.88e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1910601180 331 KIIAYKNGDGYRNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDL 386
Cdd:cd17159     2 RVLVYPNGGSPERAVYAWGKSIEELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDI 57
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 325-387 2.28e-05

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 43.40  E-value: 2.28e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  325 THQKAVKIIAYKNGDGYRNG-KLIV----AGTFPMLLTECTEQLGL--ARAASKVYTKDGTPIFTLRDLV 387
Cdd:smart00537   1 SLVKPKRIRFYRNGDRFFKGvRLVVnrkrFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELE 70
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 581-659 9.32e-05

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 41.47  E-value: 9.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  581 QPNTKRVWIYLNGGRPEDG-----TYAWGKTISELLQDCSSRLKM--THPARALYTPSGEPIQSWDDIERDMVICVSMGH 653
Cdd:smart00537   2 LVKPKRIRFYRNGDRFFKGvrlvvNRKRFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTE 81


                   ....*.
gi 1910601180  654 GFKTPK 659
Cdd:smart00537  82 AFKKVD 87
RICIN smart00458
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.
 81-181 2.13e-04

Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.


Pssm-ID: 214672 [Multi-domain]  Cd Length: 118  Bit Score: 41.34  E-value: 2.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180   81 CH-----QQFEYRDGQIISHAAPQLVLGVQGPNlrsGMEVVLVEKKSDGSHQRWIHQEDSRTFHLVSNpdLVLAVSMTKT 155
Cdd:smart00458  24 CHgtggnQLWKLTSDGAIRIKDTDLCLTANGNT---GSTVTLYSCDGTNDNQYWEVNKDGTIRNPDSG--KCLDVKDGNT 98

                           90       100
                   ....*....|....*....|....*.
gi 1910601180  156 RNEVCGYPvivqkykpyNNGAANQKW 181
Cdd:smart00458  99 GTKVILWT---------CSGNPNQKW 115
DCX1_DCDC2_like cd17071
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and ...
 331-386 9.91e-04

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340591  Cd Length: 80  Bit Score: 38.36  E-value: 9.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1910601180 331 KIIAYKNGDGYRNGKLIV-----AGTFPMLLTECTEQLGLA-RAASKVYT-KDGTPIFTLRDL 386
Cdd:cd17071     2 IIVVYKNGDPFFPGKKFVvnerqVRTFDAFLNEVTSGIKAPfGAVRSIYTpTGGHRVKDLDSL 64
beta-trefoil_Ricin_GALNT3-like cd23435
ricin B-type lectin domain, beta-trefoil fold, found in the polypeptide ...
 80-181 1.16e-03

ricin B-type lectin domain, beta-trefoil fold, found in the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)-like subfamily; The GALNT3-like subfamily includes GALNT3, GALNT4, GALNT6 and GALNT12. They act as GalNAc transferases (EC 2.4.1.41) that catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. GALNT3 has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. It probably glycosylates fibronectin in vivo as well as FGF23. It plays a central role in phosphate homeostasis. GALNT4 shows highest activity towards Muc7, EA2 and Muc2, with a lower activity compared to GALNT2. It glycosylates 'Thr-57' of SELPLG. GALNT6 may participate in the synthesis of oncofetal fibronectin. It has activity toward Muc1a, Muc2, EA2 and fibronectin peptides. GALNT12 has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with non-glycosylated Muc2 and Muc7. It displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. It may play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. Members of this family comprise a glycosyltransferase region and a ricin B-type lectin domain. The glycosyltransferase region contains two conserved domains, domain A (also called GT1 motif) and domain B (also called Gal/GalNAc-T motif). This model corresponds to the ricin B-type lectin domain with a beta-trefoil fold, which are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.


Pssm-ID: 467313 [Multi-domain]  Cd Length: 128  Bit Score: 39.62  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  80 HCH-----QQFEY-RDGQIISHAAPQLVLGVQGPNlrsgmEVVLVEKKSDG----SHQRWIHQEDSRTFHLVSNpdLVLA 149
Cdd:cd23435    33 GCHglggnQYFEYtSKGEIRHNIGKELCLHASGSD-----EVILQHCTSKGkdvpPEQKWLFTQDGTIRNPASG--LCLH 105

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1910601180 150 VSMTKTRNEVCgypvivqkykpyNNGAANQKW 181
Cdd:cd23435   106 ASGYKVLLRTC------------NPSDDSQKW 125
DCX2_DCDC5 cd17157
Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 586-641 1.20e-03

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340677  Cd Length: 86  Bit Score: 38.48  E-value: 1.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1910601180 586 RVWIYLNG-GRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDI 641
Cdd:cd17157     2 RILVFKNGdGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEA 58
DCX2_DCDC5 cd17157
Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 330-386 1.72e-03

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340677  Cd Length: 86  Bit Score: 38.10  E-value: 1.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1910601180 330 VKIIAYKNGDGyRNGKLIVAG--TFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDL 386
Cdd:cd17157     1 RRILVFKNGDG-SEGYEIVADldEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEA 58
beta-trefoil_Ricin_EW29-like cd23449
ricin B-type lectin domain, beta-trefoil fold, found in Lumbricus terrestris 29-kDa ...
 93-186 2.81e-03

ricin B-type lectin domain, beta-trefoil fold, found in Lumbricus terrestris 29-kDa galactose-binding lectin (EW29) and similar proteins; EW29 is a galactose-binding lectin from the earthworm Lumbricus terrestris. It contains two ricin B-type lectin domains with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The second ricin B-type lectin domain may harbor two sugar-binding pockets in subdomains alpha and gamma. EW29 uses these two sugar-binding sites for its function as a single domain-type hemagglutinin.


Pssm-ID: 467327 [Multi-domain]  Cd Length: 128  Bit Score: 38.43  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180  93 ISHAAPQLVLGVQGPNLRSGMEVVLVEKK-SDGSHQRWIHQEDSRTFHLVSNpDLVLavsmtktrnEVCGYP-VIVQKYK 170
Cdd:cd23449     5 IKSKLNGKVLDVEGANAKPGAKVIMWEKKgGAEDNQLWYEDEVTGTIRSKLN-DFCL---------DASGDKgLILNPYD 74

                          90
                  ....*....|....*.
gi 1910601180 171 PYNNgaaNQKWHYMKN 186
Cdd:cd23449    75 PSNP---KQQWKISGN 87
beta-trefoil_Ricin_RIPs_II_rpt2 cd23444
second ricin B-type lectin domain, beta-trefoil fold, found in type II ribosome-inactivating ...
 115-181 4.87e-03

second ricin B-type lectin domain, beta-trefoil fold, found in type II ribosome-inactivating proteins (RIPs); Type II ribosome-inactivating proteins (RIPs) inhibit translation in eukaryotes by irreversibly inactivating the 28S rRNA and preventing the binding of elongation factor II to the ribosome. They consist of a catalytic A-chain which has rRNA N-glycosidase activity and a lectin B-chain containing two ricin B-type lectin domains with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The lectin chain facilitates the internalization of the catalytic chain on binding to the cell surface. The two chains are connected by a disulfide bridge. This model corresponds to the second ricin B-type lectin domain. Members of this family includes Ricinus communis ricin, bitter gourd (Momordica charantia) seed lectin (BGSL), snake gourd (Trichosanthes anguina) seed lectin (SGSL), Sambucus ebulus ebulin I, Sambucus nigra nigrin b (also known as agglutinin V or SNAV), SNAI (also known as agglutinin I), SNAI' and SNAIf, Abrus precatorius abrin (ABR) and agglutinin-I (AAG), and Viscum album beta-galactoside-specific lectins 1-4 (also known as mistletoe lectins or MLs).


Pssm-ID: 467322 [Multi-domain]  Cd Length: 122  Bit Score: 37.64  E-value: 4.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1910601180 115 VVLVEKKSDGSHQRWIHQEDSRTFHLVSnpDLVLAVSmtktRNEVCGYPVIVQKYkpynNGAANQKW 181
Cdd:cd23444    64 IIVVLSCSGSSGQRWVFRNDGTILNLYT--GLVMDVK----ESDPSLKQIILWPA----TGGPNQQW 120
RICIN smart00458
Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.
 93-186 5.58e-03

Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication.


Pssm-ID: 214672 [Multi-domain]  Cd Length: 118  Bit Score: 37.49  E-value: 5.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910601180   93 ISHAAPQLVLGVQGPNLRsgmeVVLVEKKSDGSHQRWIHQEDSRTFHLvsNPDLVLAVSMTKtrnevcgyPVIVQKYkPY 172
Cdd:smart00458   1 IISGNTGKCLDVNGNKNP----VGLFDCHGTGGNQLWKLTSDGAIRIK--DTDLCLTANGNT--------GSTVTLY-SC 65

                           90
                   ....*....|....
gi 1910601180  173 NNGAANQKWHYMKN 186
Cdd:smart00458  66 DGTNDNQYWEVNKD 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH