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Conserved domains on  [gi|1917203551|ref|NP_001374972|]
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replication initiator 1 isoform 5 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 13416201)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
289-596 1.52e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 289 DRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIHTGEKPY-PCKECGRRFRHKPNLLS 365
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 366 HSKIHKRSEGSAQAAPGPGSPQ------------------LPAGPQESAAEPTPA---VPLKPAQEPPPGAPPEHPQDPI 424
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSrdpqlpdllsisnlrnnpLPGNNSSSVNTPQSNslhPPLPANSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 425 EAPPSLYS--CDDCGRSFRLERFLRAHQRQHTGERPFTCAECgkNFGKKTHLVAHSRVH--SGERPFACEECGR------ 494
Cdd:COG5048   191 NVSTSIPSssENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSlsSSDSSSSASESPRsslpta 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 495 RFSQGSHLAAHRRDH-APDRPFVCPDCGKAFRHKPYLAAHRR--IHTGE--KPYVCP--DCGKAFSQKSNLVSHRRIHTG 567
Cdd:COG5048   269 SSQSSSPNESDSSSEkGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTS 348

                         330       340
                  ....*....|....*....|....*....
gi 1917203551 568 ERPYACPDCDRSFSQKSNLITHRKSHIRD 596
Cdd:COG5048   349 ISPAKEKLLNSSSKFSPLLNNEPPQSLQQ 377
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
194-368 8.90e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 8.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 194 HSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICG--NCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPR 271
Cdd:COG5048   283 EKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSK 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 272 PRG-----RPAVTAPRPGGDAvDRPFQCA--CCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIH 342
Cdd:COG5048   363 FSPllnnePPQSLQQYKDLKN-DKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIH 441

                         170       180
                  ....*....|....*....|....*.
gi 1917203551 343 TgEKPYPCKECGRRFRHKPNLLSHSK 368
Cdd:COG5048   442 T-NHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
289-596 1.52e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 289 DRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIHTGEKPY-PCKECGRRFRHKPNLLS 365
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 366 HSKIHKRSEGSAQAAPGPGSPQ------------------LPAGPQESAAEPTPA---VPLKPAQEPPPGAPPEHPQDPI 424
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSrdpqlpdllsisnlrnnpLPGNNSSSVNTPQSNslhPPLPANSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 425 EAPPSLYS--CDDCGRSFRLERFLRAHQRQHTGERPFTCAECgkNFGKKTHLVAHSRVH--SGERPFACEECGR------ 494
Cdd:COG5048   191 NVSTSIPSssENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSlsSSDSSSSASESPRsslpta 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 495 RFSQGSHLAAHRRDH-APDRPFVCPDCGKAFRHKPYLAAHRR--IHTGE--KPYVCP--DCGKAFSQKSNLVSHRRIHTG 567
Cdd:COG5048   269 SSQSSSPNESDSSSEkGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTS 348

                         330       340
                  ....*....|....*....|....*....
gi 1917203551 568 ERPYACPDCDRSFSQKSNLITHRKSHIRD 596
Cdd:COG5048   349 ISPAKEKLLNSSSKFSPLLNNEPPQSLQQ 377
zf-H2C2_2 pfam13465
Zinc-finger double domain;
557-582 1.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.90e-04
                          10        20
                  ....*....|....*....|....*.
gi 1917203551 557 NLVSHRRIHTGERPYACPDCDRSFSQ 582
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-368 8.90e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 8.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 194 HSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICG--NCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPR 271
Cdd:COG5048   283 EKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSK 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 272 PRG-----RPAVTAPRPGGDAvDRPFQCA--CCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIH 342
Cdd:COG5048   363 FSPllnnePPQSLQQYKDLKN-DKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIH 441

                         170       180
                  ....*....|....*....|....*.
gi 1917203551 343 TgEKPYPCKECGRRFRHKPNLLSHSK 368
Cdd:COG5048   442 T-NHAPLLCSILKSFRRDLDLSNHGK 466
PHA00733 PHA00733
hypothetical protein
 570-623 9.53e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 9.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1917203551 570 PYACPDCDRSFSQKSNLithrKSHIR--DGAFCCAICGQTFDDEERLLAHQ-KKHDV 623
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSL----KQHIRytEHSKVCPVCGKEFRNTDSTLDHVcKKHNI 125
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
289-596 1.52e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 289 DRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIHTGEKPY-PCKECGRRFRHKPNLLS 365
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 366 HSKIHKRSEGSAQAAPGPGSPQ------------------LPAGPQESAAEPTPA---VPLKPAQEPPPGAPPEHPQDPI 424
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSrdpqlpdllsisnlrnnpLPGNNSSSVNTPQSNslhPPLPANSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 425 EAPPSLYS--CDDCGRSFRLERFLRAHQRQHTGERPFTCAECgkNFGKKTHLVAHSRVH--SGERPFACEECGR------ 494
Cdd:COG5048   191 NVSTSIPSssENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSlsSSDSSSSASESPRsslpta 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 495 RFSQGSHLAAHRRDH-APDRPFVCPDCGKAFRHKPYLAAHRR--IHTGE--KPYVCP--DCGKAFSQKSNLVSHRRIHTG 567
Cdd:COG5048   269 SSQSSSPNESDSSSEkGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTS 348

                         330       340
                  ....*....|....*....|....*....
gi 1917203551 568 ERPYACPDCDRSFSQKSNLITHRKSHIRD 596
Cdd:COG5048   349 ISPAKEKLLNSSSKFSPLLNNEPPQSLQQ 377
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
318-621 4.07e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 4.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 318 RPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFR----------------HKPNLLSHSKIHKRSEGSAQAAP 381
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsrplelsrhlrthhnNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 382 GPGS-------------------PQLP---------------------AGPQESAAEPtPAVPLKPAQEPPPGAPPEHPQ 421
Cdd:COG5048   112 SSSSnsndnnllsshslppssrdPQLPdllsisnlrnnplpgnnsssvNTPQSNSLHP-PLPANSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 422 DPIEAPPSLYSCDDCGRS-------------------------FRLERFLRAHQRQHTGER--PFTCAECGKNFGKKTHL 474
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSysipssssdqnlensssslplttnsQLSPKSLLSQSPSSLSSSdsSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 475 VAHSRVHSGER-------PFACEECGRRFSQGSHLAAHRR--DH--APDRPFVCP--DCGKAFRHKPYLAAHRRIHTGEK 541
Cdd:COG5048   271 QSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPysLCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 542 PYVCP--DCGKAFSQKSN-----LVSHRRIHTGERPYAC--PDCDRSFSQKSNLITHRKSHIRDGAFCC--AICGQTFDD 610
Cdd:COG5048   351 PAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNR 430

                         410
                  ....*....|.
gi 1917203551 611 EERLLAHQKKH 621
Cdd:COG5048   431 HYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-596 1.21e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 310 HRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFRHKPNLLSHSKIHKRSEgSAQAAPGPGSPQLP 389
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS-SSSASESPRSSLPT 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 390 AGPQESAAEPTPAVPLKpaqepppgappehpqdpieAPPSLYSCDDCGRSFRLERFLRAHQRQ--HTGE--RPFTCAE-- 463
Cdd:COG5048   268 ASSQSSSPNESDSSSEK-------------------GFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYsl 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 464 CGKNFGKKTHLVAHSRVHSGERPFAC--EECGRRFSQGSH-----LAAHRRDHAPDRPFVC--PDCGKAFRHKPYLAAHR 534
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHI 408

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1917203551 535 RIHTGEKPYVC--PDCGKAFSQKSNLVSHRRIHTGERPYACPDCDRSFSQKsnlitHRKSHIRD 596
Cdd:COG5048   409 ITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL-----DLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
291-480 4.52e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 291 PFQCACCGKRFRHKPNLIAHRR--VHTGE--RPHQCPE--CGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFRHKPNLl 364
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL- 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 365 shskiHKRSEGSAQAAPGP--GSPQLPAGPQESAAEPTPAVPLKpaqepppgappeHPQDPIEAPPSLYSCDDCGRSFRL 442
Cdd:COG5048   368 -----NNEPPQSLQQYKDLknDKKSETLSNSCIRNFKRDSNLSL------------HIITHLSFRPYNCKNPPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1917203551 443 ERFLRAHQRQHTGERPFTCAECGKNFGKKtHLVAHSRV 480
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKSFRRDL-DLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
557-582 1.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.90e-04
                          10        20
                  ....*....|....*....|....*.
gi 1917203551 557 NLVSHRRIHTGERPYACPDCDRSFSQ 582
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
529-554 2.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.55e-04
                          10        20
                  ....*....|....*....|....*.
gi 1917203551 529 YLAAHRRIHTGEKPYVCPDCGKAFSQ 554
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
334-359 3.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.52e-04
                          10        20
                  ....*....|....*....|....*.
gi 1917203551 334 YLTSHRRIHTGEKPYPCKECGRRFRH 359
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
306-331 4.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.16e-04
                          10        20
                  ....*....|....*....|....*.
gi 1917203551 306 NLIAHRRVHTGERPHQCPECGKRFTN 331
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 543-565 6.51e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 6.51e-04
                          10        20
                  ....*....|....*....|...
gi 1917203551 543 YVCPDCGKAFSQKSNLVSHRRIH 565
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 571-593 2.26e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.26e-03
                          10        20
                  ....*....|....*....|...
gi 1917203551 571 YACPDCDRSFSQKSNLITHRKSH 593
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 320-342 4.82e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.82e-03
                          10        20
                  ....*....|....*....|...
gi 1917203551 320 HQCPECGKRFTNKPYLTSHRRIH 342
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 515-537 6.66e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.66e-03
                          10        20
                  ....*....|....*....|...
gi 1917203551 515 FVCPDCGKAFRHKPYLAAHRRIH 537
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-368 8.90e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 8.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 194 HSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICG--NCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPR 271
Cdd:COG5048   283 EKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSK 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203551 272 PRG-----RPAVTAPRPGGDAvDRPFQCA--CCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIH 342
Cdd:COG5048   363 FSPllnnePPQSLQQYKDLKN-DKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIH 441

                         170       180
                  ....*....|....*....|....*.
gi 1917203551 343 TgEKPYPCKECGRRFRHKPNLLSHSK 368
Cdd:COG5048   442 T-NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-468 9.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.26e-03
                          10        20
                  ....*....|....*....|...
gi 1917203551 446 LRAHQRQHTGERPFTCAECGKNF 468
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
PHA00733 PHA00733
hypothetical protein
 570-623 9.53e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 9.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1917203551 570 PYACPDCDRSFSQKSNLithrKSHIR--DGAFCCAICGQTFDDEERLLAHQ-KKHDV 623
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSL----KQHIRytEHSKVCPVCGKEFRNTDSTLDHVcKKHNI 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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