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Conserved domains on  [gi|1933851641|ref|NP_001375421|]
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huntingtin isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3652 pfam12372
Huntingtin protein region; This domain family is found in eukaryotes, and is approximately 40 ...
 1513-1553 2.78e-16

Huntingtin protein region; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam02985. This family is in the middle region of the Huntingtin protein associated with Huntington's disease. The protein is of unknown function, however it is known that a polyglutamine (CAG) repeat in the gene coding for it results in the development of Huntington's disease.


:

Pssm-ID: 463554  Cd Length: 41  Bit Score: 74.79  E-value: 2.78e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1933851641 1513 QIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLR 1553
Cdd:pfam12372    1 AIIGQPRIIQLCDGLMASGQPAVRHEIPALRPILQDTFFYR 41
HEAT COG1413
HEAT repeat [General function prediction only];
805-934 7.42e-03

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.23  E-value: 7.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933851641  805 ADCIPLLRKTLKDESSVTCKLACTAVrncvmslcsssySELGLQLIIDVL--TLRNSSyWLVRTELLETLAEIDFR---- 878
Cdd:COG1413     15 PAAVPALIAALADEDPDVRAAAARAL------------GRLGDPRAVPALleALKDPD-PEVRAAAAEALGRIGDPeavp 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1933851641  879 -LVSFLEAKAENLHRGAhhYTGLLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRL 934
Cdd:COG1413     82 aLIAALKDEDPEVRRAA--AEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGRL 136
 
Name Accession Description Interval E-value
DUF3652 pfam12372
Huntingtin protein region; This domain family is found in eukaryotes, and is approximately 40 ...
 1513-1553 2.78e-16

Huntingtin protein region; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam02985. This family is in the middle region of the Huntingtin protein associated with Huntington's disease. The protein is of unknown function, however it is known that a polyglutamine (CAG) repeat in the gene coding for it results in the development of Huntington's disease.


Pssm-ID: 463554  Cd Length: 41  Bit Score: 74.79  E-value: 2.78e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1933851641 1513 QIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLR 1553
Cdd:pfam12372    1 AIIGQPRIIQLCDGLMASGQPAVRHEIPALRPILQDTFFYR 41
HEAT COG1413
HEAT repeat [General function prediction only];
805-934 7.42e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.23  E-value: 7.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933851641  805 ADCIPLLRKTLKDESSVTCKLACTAVrncvmslcsssySELGLQLIIDVL--TLRNSSyWLVRTELLETLAEIDFR---- 878
Cdd:COG1413     15 PAAVPALIAALADEDPDVRAAAARAL------------GRLGDPRAVPALleALKDPD-PEVRAAAAEALGRIGDPeavp 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1933851641  879 -LVSFLEAKAENLHRGAhhYTGLLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRL 934
Cdd:COG1413     82 aLIAALKDEDPEVRRAA--AEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGRL 136
 
Name Accession Description Interval E-value
DUF3652 pfam12372
Huntingtin protein region; This domain family is found in eukaryotes, and is approximately 40 ...
 1513-1553 2.78e-16

Huntingtin protein region; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam02985. This family is in the middle region of the Huntingtin protein associated with Huntington's disease. The protein is of unknown function, however it is known that a polyglutamine (CAG) repeat in the gene coding for it results in the development of Huntington's disease.


Pssm-ID: 463554  Cd Length: 41  Bit Score: 74.79  E-value: 2.78e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1933851641 1513 QIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLR 1553
Cdd:pfam12372    1 AIIGQPRIIQLCDGLMASGQPAVRHEIPALRPILQDTFFYR 41
HEAT COG1413
HEAT repeat [General function prediction only];
805-934 7.42e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.23  E-value: 7.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933851641  805 ADCIPLLRKTLKDESSVTCKLACTAVrncvmslcsssySELGLQLIIDVL--TLRNSSyWLVRTELLETLAEIDFR---- 878
Cdd:COG1413     15 PAAVPALIAALADEDPDVRAAAARAL------------GRLGDPRAVPALleALKDPD-PEVRAAAAEALGRIGDPeavp 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1933851641  879 -LVSFLEAKAENLHRGAhhYTGLLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRL 934
Cdd:COG1413     82 aLIAALKDEDPEVRRAA--AEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGRL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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