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Conserved domains on  [gi|1959220892|ref|NP_001378880|]
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inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 9 [Homo sapiens]

Protein Classification

ubiquitin carboxyl-terminal hydrolase family protein( domain architecture ID 913)

ubiquitin carboxyl-terminal hydrolase family protein is a C19 family peptidase that may deubiquitinate polyubiquitinated target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_C19 super family cl02553
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 32-128 2.81e-10

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


The actual alignment was detected with superfamily member pfam00443:

Pssm-ID: 470612 [Multi-domain]  Cd Length: 310  Bit Score: 63.23  E-value: 2.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959220892   32 GLSNePGqNSCFLNSALQVLWHLDIFRRSFRQLTTHKC----MGDSCIFCALKGIFNQFQC-SSEKVLPSDTLRSALAKT 106
Cdd:pfam00443    2 GLVN-LG-NTCYMNSVLQSLFSIPPFRDYLLRISPLSEdsryNKDINLLCALRDLFKALQKnSKSSSVSPKMFKKSLGKL 79

                           90       100
                   ....*....|....*....|..
gi 1959220892  107 FQDeqrFQLGIMDDAAECFLFF 128
Cdd:pfam00443   80 NPD---FSGYKQQDAQEFLLFL 98
 
Name Accession Description Interval E-value
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
32-128 2.81e-10

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 63.23  E-value: 2.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959220892   32 GLSNePGqNSCFLNSALQVLWHLDIFRRSFRQLTTHKC----MGDSCIFCALKGIFNQFQC-SSEKVLPSDTLRSALAKT 106
Cdd:pfam00443    2 GLVN-LG-NTCYMNSVLQSLFSIPPFRDYLLRISPLSEdsryNKDINLLCALRDLFKALQKnSKSSSVSPKMFKKSLGKL 79

                           90       100
                   ....*....|....*....|..
gi 1959220892  107 FQDeqrFQLGIMDDAAECFLFF 128
Cdd:pfam00443   80 NPD---FSGYKQQDAQEFLLFL 98
Peptidase_C19E cd02661
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 32-128 4.18e-06

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239126 [Multi-domain]  Cd Length: 304  Bit Score: 50.35  E-value: 4.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959220892   32 GLSNePGqNSCFLNSALQVLWH---LDIFRRSfRQLTTHKCMGDSCIFCALKGIFNQFQCSSEKVLPSDTLRSALAktfQ 108
Cdd:cd02661      3 GLQN-LG-NTCFLNSVLQCLTHtppLANYLLS-REHSKDCCNEGFCMMCALEAHVERALASSGPGSAPRIFSSNLK---Q 76

                           90       100
                   ....*....|....*....|
gi 1959220892  109 DEQRFQLGIMDDAAEcFLFF 128
Cdd:cd02661     77 ISKHFRIGRQEDAHE-FLRY 95
 
Name Accession Description Interval E-value
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
32-128 2.81e-10

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 63.23  E-value: 2.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959220892   32 GLSNePGqNSCFLNSALQVLWHLDIFRRSFRQLTTHKC----MGDSCIFCALKGIFNQFQC-SSEKVLPSDTLRSALAKT 106
Cdd:pfam00443    2 GLVN-LG-NTCYMNSVLQSLFSIPPFRDYLLRISPLSEdsryNKDINLLCALRDLFKALQKnSKSSSVSPKMFKKSLGKL 79

                           90       100
                   ....*....|....*....|..
gi 1959220892  107 FQDeqrFQLGIMDDAAECFLFF 128
Cdd:pfam00443   80 NPD---FSGYKQQDAQEFLLFL 98
Peptidase_C19E cd02661
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 32-128 4.18e-06

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239126 [Multi-domain]  Cd Length: 304  Bit Score: 50.35  E-value: 4.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959220892   32 GLSNePGqNSCFLNSALQVLWH---LDIFRRSfRQLTTHKCMGDSCIFCALKGIFNQFQCSSEKVLPSDTLRSALAktfQ 108
Cdd:cd02661      3 GLQN-LG-NTCFLNSVLQCLTHtppLANYLLS-REHSKDCCNEGFCMMCALEAHVERALASSGPGSAPRIFSSNLK---Q 76

                           90       100
                   ....*....|....*....|
gi 1959220892  109 DEQRFQLGIMDDAAEcFLFF 128
Cdd:cd02661     77 ISKHFRIGRQEDAHE-FLRY 95
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 32-199 1.39e-05

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 48.25  E-value: 1.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959220892   32 GLSNEPgqNSCFLNSALQVLWH------------LDIFRRSFRQLTTHKCMGDSCIfCALKGIF-----NQFQCSS---- 90
Cdd:cd02257      1 GLNNLG--NTCYLNSVLQALFSeqqdahefllflLDKLHEELKKSSKRTSDSSSLK-SLIHDLFggkleSTIVCLEcghe 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959220892   91 ---------------EKVLPSDTLRSALAKTFQDEQ-----------------------------------RFQLG---- 116
Cdd:cd02257     78 svstepelflslplpVKGLPQVSLEDCLEKFFKEEIlegdncykcekkkkqeatkrlkikklppvliihlkRFSFNedgt 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959220892  117 -----------IMDDAAECFLFFRVTDDRAKQSELY-LVGMICYYGK-----HYSTFFFQTKIRKWMYFDDAHVKEIgpK 179
Cdd:cd02257    158 keklntkvsfpLELDLSPYLSEGEKDSDSDNGSYKYeLVAVVVHSGTsadsgHYVAYVKDPSDGKWYKFNDDKVTEV--S 235

                          250       260
                   ....*....|....*....|
gi 1959220892  180 WKDVVTKCIKGHyQPLLLLY 199
Cdd:cd02257    236 EEEVLEFGSLSS-SAYILFY 254
Peptidase_C19D cd02660
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-92 6.67e-04

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239125 [Multi-domain]  Cd Length: 328  Bit Score: 43.52  E-value: 6.67e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1959220892   40 NSCFLNSALQVLWHLDIFRRSF----RQLTTHKCMGDSCIFCALKGIFNQFQCSSEK 92
Cdd:cd02660      8 ATCFMNVILQALLHNPLLRNYFlsdrHSCTCLSCSPNSCLSCAMDEIFQEFYYSGDR 64
Peptidase_C19A cd02657
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 40-125 1.30e-03

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239122 [Multi-domain]  Cd Length: 305  Bit Score: 42.70  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959220892   40 NSCFLNSALQVLWHLDIFR---RSFRQLTTHKCMGDSCIFCALKGIFNQFQCSSEKVLPS---DTLRsALAKTFQDEQRF 113
Cdd:cd02657      7 NTCYLNSTLQCLRSVPELRdalKNYNPARRGANQSSDNLTNALRDLFDTMDKKQEPVPPIeflQLLR-MAFPQFAEKQNQ 85

                           90
                   ....*....|..
gi 1959220892  114 QLGIMDDAAECF 125
Cdd:cd02657     86 GGYAQQDAEECW 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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