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Conserved domains on  [gi|1972711434|ref|NP_001378986|]
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janus kinase and microtubule-interacting protein 3 isoform n [Homo sapiens]

Protein Classification

SMC_prok_B and JAKMIP_CC3 domain-containing protein( domain architecture ID 13531091)

SMC_prok_B and JAKMIP_CC3 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
JAKMIP_CC3 pfam16034
JAKMIP CC3 domain; This domain is found at the C-terminus of proteins belonging to the JAKMIP ...
357-553 6.97e-85

JAKMIP CC3 domain; This domain is found at the C-terminus of proteins belonging to the JAKMIP family (Janus kinase and microtubule-interacting proteins) and is predicted to be a coiled coil. It interacts with the Janus family kinases Tyk2 and Jak1.


:

Pssm-ID: 464986 [Multi-domain]  Cd Length: 199  Bit Score: 267.52  E-value: 6.97e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 357 ERDKLLRFRKQRKKMAKLPKP-VVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTM 435
Cdd:pfam16034   1 ERDKLIRARKQRRKEKKKKLRdMVVETFFGYDEEASVDSETSSLSYNTDRTDSTPATPDEDLDEGVAAEEAELRFRQLTR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 436 EYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQM 515
Cdd:pfam16034  81 EYQALQRAYALLQEQSGGTLDAEREAKTREQLQAELRRAQSRIEDLESALAQKGQDSKWVEEKQALIRRNQELVEKIRIM 160
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1972711434 516 ETEEARLRHEVQDARDQNELLEFRILELEERERKSPAI 553
Cdd:pfam16034 161 EQEEGRLKNEIQDARDQNELLEFRILELEERERRSPAI 198
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
26-547 4.71e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.50  E-value: 4.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  26 EDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTELKTKLHEEKmKELQAVRETlLRQHEAELLRV 105
Cdd:COG1196   223 KELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELE-LELEEAQAE-EYELLAELARL 300
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 106 IKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAE 185
Cdd:COG1196   301 EQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE 380
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 186 IRSVYHLHQEEITRI--KKECEREIRRLEQQLDEKDARRFQLKIAELSAIIRKLEDRNAL---LSEERNELLKRVREAES 260
Cdd:COG1196   381 LEELAEELLEALRAAaeLAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEeeaLEEAAEEEAELEEEEEA 460
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 261 QYKPLLDKNKRLSRKNEDLSHALR-RMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLI 339
Cdd:COG1196   461 LLELLAELLEEAALLEAALAELLEeLAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 340 DELSKTLETAGYVKSVLERDKLLRFRKQRK--KMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDL 417
Cdd:COG1196   541 EAALAAALQNIVVEDDEVAAAAIEYLKAAKagRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGD 620
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 418 EEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQgqdmkwIEE 497
Cdd:COG1196   621 TLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEE------ELE 694
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 1972711434 498 KQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERE 547
Cdd:COG1196   695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEE 744
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
423-749 6.02e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.48  E-value: 6.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 423 KEETELRFRQLTMEYQALQRAYALLQEQVG-GTLDAEREVKTREQLQAEVQRAQARIEDLEKALAE-QGQDMKWIEEKQA 500
Cdd:COG1196   220 EELKELEAELLLLKLRELEAELEELEAELEeLEAELEELEAELAELEAELEELRLELEELELELEEaQAEEYELLAELAR 299
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 501 LYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERErkspaisfhhtpfvdgksplqvyceaegvtdiv 580
Cdd:COG1196   300 LEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEEL--------------------------------- 346
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 581 vAELMKKLDilgdnanltnEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQA 660
Cdd:COG1196   347 -EEAEEELE----------EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLER 415
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 661 LDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQwKRQVMSELRERDAQILRERMELLQLAQQRIKELE 740
Cdd:COG1196   416 LERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEA-LLELLAELLEEAALLEAALAELLEELAEAAARLL 494

                  ....*....
gi 1972711434 741 ERIEAQKRQ 749
Cdd:COG1196   495 LLLEAEADY 503
 
Name Accession Description Interval E-value
JAKMIP_CC3 pfam16034
JAKMIP CC3 domain; This domain is found at the C-terminus of proteins belonging to the JAKMIP ...
357-553 6.97e-85

JAKMIP CC3 domain; This domain is found at the C-terminus of proteins belonging to the JAKMIP family (Janus kinase and microtubule-interacting proteins) and is predicted to be a coiled coil. It interacts with the Janus family kinases Tyk2 and Jak1.


Pssm-ID: 464986 [Multi-domain]  Cd Length: 199  Bit Score: 267.52  E-value: 6.97e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 357 ERDKLLRFRKQRKKMAKLPKP-VVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTM 435
Cdd:pfam16034   1 ERDKLIRARKQRRKEKKKKLRdMVVETFFGYDEEASVDSETSSLSYNTDRTDSTPATPDEDLDEGVAAEEAELRFRQLTR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 436 EYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQM 515
Cdd:pfam16034  81 EYQALQRAYALLQEQSGGTLDAEREAKTREQLQAELRRAQSRIEDLESALAQKGQDSKWVEEKQALIRRNQELVEKIRIM 160
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1972711434 516 ETEEARLRHEVQDARDQNELLEFRILELEERERKSPAI 553
Cdd:pfam16034 161 EQEEGRLKNEIQDARDQNELLEFRILELEERERRSPAI 198
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
26-547 4.71e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.50  E-value: 4.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  26 EDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTELKTKLHEEKmKELQAVRETlLRQHEAELLRV 105
Cdd:COG1196   223 KELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELE-LELEEAQAE-EYELLAELARL 300
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 106 IKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAE 185
Cdd:COG1196   301 EQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE 380
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 186 IRSVYHLHQEEITRI--KKECEREIRRLEQQLDEKDARRFQLKIAELSAIIRKLEDRNAL---LSEERNELLKRVREAES 260
Cdd:COG1196   381 LEELAEELLEALRAAaeLAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEeeaLEEAAEEEAELEEEEEA 460
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 261 QYKPLLDKNKRLSRKNEDLSHALR-RMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLI 339
Cdd:COG1196   461 LLELLAELLEEAALLEAALAELLEeLAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 340 DELSKTLETAGYVKSVLERDKLLRFRKQRK--KMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDL 417
Cdd:COG1196   541 EAALAAALQNIVVEDDEVAAAAIEYLKAAKagRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGD 620
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 418 EEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQgqdmkwIEE 497
Cdd:COG1196   621 TLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEE------ELE 694
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 1972711434 498 KQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERE 547
Cdd:COG1196   695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEE 744
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
27-746 7.12e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.85  E-value: 7.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434   27 DLRAKLTDIQIELQ--QEKSKVSKVEREKNQELRQVREHEQHKTAV-----LLTELKTKLHEEKMKELQAVRETL-LRQH 98
Cdd:TIGR02168  217 ELKAELRELELALLvlRLEELREELEELQEELKEAEEELEELTAELqeleeKLEELRLEVSELEEEIEELQKELYaLANE 296
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434   99 EAELLRVIKIKDNENQRLQALLSALRDGGPE-KVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQ 177
Cdd:TIGR02168  297 ISRLEQQKQILRERLANLERQLEELEAQLEElESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEE 376
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  178 ADKiKAAEIRSVYHLHQEEITRIKKECER-----------------EIRRLEQQLDEKDARRFQLKIAELSAIIRKLEDR 240
Cdd:TIGR02168  377 LEE-QLETLRSKVAQLELQIASLNNEIERlearlerledrrerlqqEIEELLKKLEEAELKELQAELEELEEELEELQEE 455
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  241 NALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDqSQ 320
Cdd:TIGR02168  456 LERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVD-EG 534
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  321 DEREVDflklqIVEQQNLIDELSKTLETAGYVKSVLERDKLLRfrkqrkkMAKLPKPVVVETFFGYDEEASLESDGSSVS 400
Cdd:TIGR02168  535 YEAAIE-----AALGGRLQAVVVENLNAAKKAIAFLKQNELGR-------VTFLPLDSIKGTEIQGNDREILKNIEGFLG 602
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  401 YQTDRTDQTP------------CTPDDDLEEGMA-KEETELRFRQLTMEYQALQRAYALLQ---EQVGGTLDAEREVktr 464
Cdd:TIGR02168  603 VAKDLVKFDPklrkalsyllggVLVVDDLDNALElAKKLRPGYRIVTLDGDLVRPGGVITGgsaKTNSSILERRREI--- 679
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  465 EQLQAEVQRAQARIEDLEKALAE---QGQDMKwiEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRIL 541
Cdd:TIGR02168  680 EELEEKIEELEEKIAELEKALAElrkELEELE--EELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELT 757
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  542 ELEERERKSpaisfhhtpfvdgKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVvviQARTVLTLAEKWLQQ 621
Cdd:TIGR02168  758 ELEAEIEEL-------------EERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALD---ELRAELTLLNEEAAN 821
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  622 IEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKV 701
Cdd:TIGR02168  822 LRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSE 901
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*
gi 1972711434  702 AVEQWKRQVMSELRERDAqiLRERMELLQLAQQRIKELEERIEAQ 746
Cdd:TIGR02168  902 ELRELESKRSELRRELEE--LREKLAQLELRLEGLEVRIDNLQER 944
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
423-749 6.02e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.48  E-value: 6.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 423 KEETELRFRQLTMEYQALQRAYALLQEQVG-GTLDAEREVKTREQLQAEVQRAQARIEDLEKALAE-QGQDMKWIEEKQA 500
Cdd:COG1196   220 EELKELEAELLLLKLRELEAELEELEAELEeLEAELEELEAELAELEAELEELRLELEELELELEEaQAEEYELLAELAR 299
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 501 LYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERErkspaisfhhtpfvdgksplqvyceaegvtdiv 580
Cdd:COG1196   300 LEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEEL--------------------------------- 346
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 581 vAELMKKLDilgdnanltnEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQA 660
Cdd:COG1196   347 -EEAEEELE----------EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLER 415
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 661 LDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQwKRQVMSELRERDAQILRERMELLQLAQQRIKELE 740
Cdd:COG1196   416 LERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEA-LLELLAELLEEAALLEAALAELLEELAEAAARLL 494

                  ....*....
gi 1972711434 741 ERIEAQKRQ 749
Cdd:COG1196   495 LLLEAEADY 503
PTZ00121 PTZ00121
MAEBL; Provisional
41-287 5.01e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 5.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434   41 QEKSKVS---KVEREKNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAvretllRQHEAELLRVIKIKDNENQRLQ 117
Cdd:PTZ00121  1561 EEKKKAEeakKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEA------KKAEEAKIKAEELKKAEEEKKK 1634
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  118 alLSALRDGGPEKVKTVllseakEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLviQADKIKAAEIRSVYHLHQEEI 197
Cdd:PTZ00121  1635 --VEQLKKKEAEEKKKA------EELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKA--EEDEKKAAEALKKEAEEAKKA 1704
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  198 TRIKKECEREIRRLEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSE-ERNELLKRVREAESQYKPLLDKNKRLSRKN 276
Cdd:PTZ00121  1705 EELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEeEKKKIAHLKKEEEKKAEEIRKEKEAVIEEE 1784
                          250
                   ....*....|.
gi 1972711434  277 EDLSHALRRME 287
Cdd:PTZ00121  1785 LDEEDEKRRME 1795
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
424-548 2.71e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 2.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  424 EETELRFRQLTMEYQALQRAYALLQEQvggtLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWI----EEKQ 499
Cdd:COG4913    620 AELEEELAEAEERLEALEAELDALQER----REALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDDLaaleEQLE 695
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1972711434  500 ALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERER 548
Cdd:COG4913    696 ELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLAR 744
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
423-747 3.07e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 3.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  423 KEETELRFRQLTMEYQALQRAYALLQEQVggtldaEREVKTREQLQAEVQRAQARIEDLEKALAEQGqdmkwiEEKQALY 502
Cdd:TIGR02168  220 AELRELELALLVLRLEELREELEELQEEL------KEAEEELEELTAELQELEEKLEELRLEVSELE------EEIEELQ 287
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  503 RRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAISfhhTPFVDGKSPLQVYCEAEgvtdivVA 582
Cdd:TIGR02168  288 KELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEEL---AELEEKLEELKEELESL------EA 358
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  583 ELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEkwlQQIEETEAALQRkmvdLESEKELFSKQKGYLDEELDYRKQALD 662
Cdd:TIGR02168  359 ELEELEAELEELESRLEELEEQLETLRSKVAQLE---LQIASLNNEIER----LEARLERLEDRRERLQQEIEELLKKLE 431
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  663 QANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQvmseLRERDAQILRERMELLQLAQQRIKELEER 742
Cdd:TIGR02168  432 EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALD----AAERELAQLQARLDSLERLQENLEGFSEG 507

                   ....*
gi 1972711434  743 IEAQK 747
Cdd:TIGR02168  508 VKALL 512
 
Name Accession Description Interval E-value
JAKMIP_CC3 pfam16034
JAKMIP CC3 domain; This domain is found at the C-terminus of proteins belonging to the JAKMIP ...
357-553 6.97e-85

JAKMIP CC3 domain; This domain is found at the C-terminus of proteins belonging to the JAKMIP family (Janus kinase and microtubule-interacting proteins) and is predicted to be a coiled coil. It interacts with the Janus family kinases Tyk2 and Jak1.


Pssm-ID: 464986 [Multi-domain]  Cd Length: 199  Bit Score: 267.52  E-value: 6.97e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 357 ERDKLLRFRKQRKKMAKLPKP-VVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEETELRFRQLTM 435
Cdd:pfam16034   1 ERDKLIRARKQRRKEKKKKLRdMVVETFFGYDEEASVDSETSSLSYNTDRTDSTPATPDEDLDEGVAAEEAELRFRQLTR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 436 EYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQM 515
Cdd:pfam16034  81 EYQALQRAYALLQEQSGGTLDAEREAKTREQLQAELRRAQSRIEDLESALAQKGQDSKWVEEKQALIRRNQELVEKIRIM 160
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1972711434 516 ETEEARLRHEVQDARDQNELLEFRILELEERERKSPAI 553
Cdd:pfam16034 161 EQEEGRLKNEIQDARDQNELLEFRILELEERERRSPAI 198
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
26-547 4.71e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.50  E-value: 4.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  26 EDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTELKTKLHEEKmKELQAVRETlLRQHEAELLRV 105
Cdd:COG1196   223 KELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELE-LELEEAQAE-EYELLAELARL 300
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 106 IKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAE 185
Cdd:COG1196   301 EQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE 380
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 186 IRSVYHLHQEEITRI--KKECEREIRRLEQQLDEKDARRFQLKIAELSAIIRKLEDRNAL---LSEERNELLKRVREAES 260
Cdd:COG1196   381 LEELAEELLEALRAAaeLAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEeeaLEEAAEEEAELEEEEEA 460
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 261 QYKPLLDKNKRLSRKNEDLSHALR-RMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLI 339
Cdd:COG1196   461 LLELLAELLEEAALLEAALAELLEeLAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 340 DELSKTLETAGYVKSVLERDKLLRFRKQRK--KMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDL 417
Cdd:COG1196   541 EAALAAALQNIVVEDDEVAAAAIEYLKAAKagRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGD 620
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 418 EEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQgqdmkwIEE 497
Cdd:COG1196   621 TLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEE------ELE 694
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 1972711434 498 KQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERE 547
Cdd:COG1196   695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEE 744
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
27-746 7.12e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.85  E-value: 7.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434   27 DLRAKLTDIQIELQ--QEKSKVSKVEREKNQELRQVREHEQHKTAV-----LLTELKTKLHEEKMKELQAVRETL-LRQH 98
Cdd:TIGR02168  217 ELKAELRELELALLvlRLEELREELEELQEELKEAEEELEELTAELqeleeKLEELRLEVSELEEEIEELQKELYaLANE 296
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434   99 EAELLRVIKIKDNENQRLQALLSALRDGGPE-KVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQ 177
Cdd:TIGR02168  297 ISRLEQQKQILRERLANLERQLEELEAQLEElESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEE 376
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  178 ADKiKAAEIRSVYHLHQEEITRIKKECER-----------------EIRRLEQQLDEKDARRFQLKIAELSAIIRKLEDR 240
Cdd:TIGR02168  377 LEE-QLETLRSKVAQLELQIASLNNEIERlearlerledrrerlqqEIEELLKKLEEAELKELQAELEELEEELEELQEE 455
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  241 NALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDqSQ 320
Cdd:TIGR02168  456 LERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVD-EG 534
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  321 DEREVDflklqIVEQQNLIDELSKTLETAGYVKSVLERDKLLRfrkqrkkMAKLPKPVVVETFFGYDEEASLESDGSSVS 400
Cdd:TIGR02168  535 YEAAIE-----AALGGRLQAVVVENLNAAKKAIAFLKQNELGR-------VTFLPLDSIKGTEIQGNDREILKNIEGFLG 602
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  401 YQTDRTDQTP------------CTPDDDLEEGMA-KEETELRFRQLTMEYQALQRAYALLQ---EQVGGTLDAEREVktr 464
Cdd:TIGR02168  603 VAKDLVKFDPklrkalsyllggVLVVDDLDNALElAKKLRPGYRIVTLDGDLVRPGGVITGgsaKTNSSILERRREI--- 679
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  465 EQLQAEVQRAQARIEDLEKALAE---QGQDMKwiEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRIL 541
Cdd:TIGR02168  680 EELEEKIEELEEKIAELEKALAElrkELEELE--EELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELT 757
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  542 ELEERERKSpaisfhhtpfvdgKSPLQVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVvviQARTVLTLAEKWLQQ 621
Cdd:TIGR02168  758 ELEAEIEEL-------------EERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALD---ELRAELTLLNEEAAN 821
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  622 IEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKV 701
Cdd:TIGR02168  822 LRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSE 901
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*
gi 1972711434  702 AVEQWKRQVMSELRERDAqiLRERMELLQLAQQRIKELEERIEAQ 746
Cdd:TIGR02168  902 ELRELESKRSELRRELEE--LREKLAQLELRLEGLEVRIDNLQER 944
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
26-547 1.95e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.02  E-value: 1.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  26 EDLRAKLTDIQIELQQEKSKVskveREKNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRV 105
Cdd:COG1196   256 EELEAELAELEAELEELRLEL----EELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEE 331
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 106 IKIKDNENQRLQALLSALRdggpekvktvllsEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAE 185
Cdd:COG1196   332 LEELEEELEELEEELEEAE-------------EELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 186 IRSVYHLHQEEITRIKKECEREIRRLEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPL 265
Cdd:COG1196   399 AAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAA 478
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 266 LDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLK-LQIVEQQNLIDELSK 344
Cdd:COG1196   479 LAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAaLAAALQNIVVEDDEV 558
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 345 TLETAGYVKS-VLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQ-TPCTPDDDLEEGMA 422
Cdd:COG1196   559 AAAAIEYLKAaKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLgRTLVAARLEAALRR 638
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 423 KEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALY 502
Cdd:COG1196   639 AVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLE 718
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1972711434 503 RRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERE 547
Cdd:COG1196   719 EELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLE 763
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
423-749 6.02e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.48  E-value: 6.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 423 KEETELRFRQLTMEYQALQRAYALLQEQVG-GTLDAEREVKTREQLQAEVQRAQARIEDLEKALAE-QGQDMKWIEEKQA 500
Cdd:COG1196   220 EELKELEAELLLLKLRELEAELEELEAELEeLEAELEELEAELAELEAELEELRLELEELELELEEaQAEEYELLAELAR 299
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 501 LYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERErkspaisfhhtpfvdgksplqvyceaegvtdiv 580
Cdd:COG1196   300 LEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEEL--------------------------------- 346
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 581 vAELMKKLDilgdnanltnEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQA 660
Cdd:COG1196   347 -EEAEEELE----------EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLER 415
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 661 LDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQwKRQVMSELRERDAQILRERMELLQLAQQRIKELE 740
Cdd:COG1196   416 LERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEA-LLELLAELLEEAALLEAALAELLEELAEAAARLL 494

                  ....*....
gi 1972711434 741 ERIEAQKRQ 749
Cdd:COG1196   495 LLLEAEADY 503
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
158-751 1.25e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 55.33  E-value: 1.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 158 ISELKGAKRQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKK---ECEREIRRLEQQLDEKDARrfqlkIAELSAII 234
Cdd:COG1196   202 LEPLERQAEKAERYRELKEELKELEAELLLLKLRELEAELEELEAeleELEAELEELEAELAELEAE-----LEELRLEL 276
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 235 RKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRP---- 310
Cdd:COG1196   277 EELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEEleea 356
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 311 -SSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQRKKMAKlpkpvvvetffgyDEE 389
Cdd:COG1196   357 eAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLE-------------EEL 423
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 390 ASLESDGSSVSYQTDRTDQTpctpddDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQA 469
Cdd:COG1196   424 EELEEALAELEEEEEEEEEA------LEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLL 497
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 470 EVQR-AQARIEDLEKALAEQGQDMKWIEEkqALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERER 548
Cdd:COG1196   498 EAEAdYEGFLEGVKAALLLAGLRGLAGAV--AVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRAT 575
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 549 KSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAELMKKLDILGDNAnltneeqVVVIQARTVLTLAEKWLQQIEETEAA 628
Cdd:COG1196   576 FLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTL-------LGRTLVAARLEAALRRAVTLAGRLRE 648
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 629 LQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQwKR 708
Cdd:COG1196   649 VTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEA-LE 727
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 1972711434 709 QVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIK 751
Cdd:COG1196   728 EQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELE 770
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
50-751 4.83e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 53.53  E-value: 4.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434   50 EREKNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAVRETLlRQHEAELLRVIKIKDNENQRLQALLSALRDGGPE 129
Cdd:TIGR02169  252 ELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKI-GELEAEIASLERSIAEKERELEDAEERLAKLEAE 330
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  130 KVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKgakrQVEEALTLVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIR 209
Cdd:TIGR02169  331 IDKLLAEIEELEREIEEERKRRDKLTEEYAELK----EELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKR 406
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  210 RLEQQLDEKdaRRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENK 289
Cdd:TIGR02169  407 ELDRLQEEL--QRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKE 484
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  290 LKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLETAG-------YVKSVLERDKLL 362
Cdd:TIGR02169  485 LSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAgnrlnnvVVEDDAVAKEAI 564
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  363 RFRKQRK----------KMAKLPKPVVVETFFGYDEEA----SLESDGSSVSYQTDRTDQTPctpdDDLEEGmakEETEL 428
Cdd:TIGR02169  565 ELLKRRKagratflplnKMRDERRDLSILSEDGVIGFAvdlvEFDPKYEPAFKYVFGDTLVV----EDIEAA---RRLMG 637
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  429 RFRQLTMEYQALQRAYALlqeqVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEekQALYRRNQEL 508
Cdd:TIGR02169  638 KYRMVTLEGELFEKSGAM----TGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIE--NRLDELSQEL 711
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  509 VEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAIsfhhtpfvdgKSPLQvycEAEGVTDIVVAELMKKL 588
Cdd:TIGR02169  712 SDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENV----------KSELK---ELEARIEELEEDLHKLE 778
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  589 DILGDNANLTNEEQVVVIQARtvLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHI 668
Cdd:TIGR02169  779 EALNDLEARLSHSRIPEIQAE--LSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEI 856
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  669 LELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQvMSELRERdaqiLRERMELLQLAQQRIKELEERIEAQKR 748
Cdd:TIGR02169  857 ENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQ-LRELERK----IEELEAQIEKKRKRLSELKAKLEALEE 931

                   ...
gi 1972711434  749 QIK 751
Cdd:TIGR02169  932 ELS 934
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
209-771 6.01e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 6.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 209 RRLEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMEN 288
Cdd:COG1196   216 RELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLA 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 289 KLkfvtqENIEMRQRAGIIRRPSSLNDLDQSQDEREVdfLKLQIVEQQNLIDELSKTLETAgyvksvlerdkLLRFRKQR 368
Cdd:COG1196   296 EL-----ARLEQDIARLEERRRELEERLEELEEELAE--LEEELEELEEELEELEEELEEA-----------EEELEEAE 357
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 369 KKMAKLpkpvvvetffgydEEASLESDGSSVSYQTDRTDQTpctpDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQ 448
Cdd:COG1196   358 AELAEA-------------EEALLEAEAELAEAEEELEELA----EELLEALRAAAELAAQLEELEEAEEALLERLERLE 420
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 449 EQVGGTLDAEREVktREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRHEVQD 528
Cdd:COG1196   421 EELEELEEALAEL--EEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLE 498
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 529 ARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVY-CEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQ 607
Cdd:COG1196   499 AEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALeAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLP 578
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 608 ARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKV 687
Cdd:COG1196   579 LDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA 658
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 688 AELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEKFLFLFLFFSLA 767
Cdd:COG1196   659 GGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELL 738

                  ....
gi 1972711434 768 FILW 771
Cdd:COG1196   739 EELL 742
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
26-523 1.31e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.70  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  26 EDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRV 105
Cdd:COG1196   347 EEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL 426
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 106 IKIKDNENQRLQALLSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKIKAAE 185
Cdd:COG1196   427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGF 506
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 186 IRSVYHLHQEEITRIKKECEREIRRLEQQLDEKDArrfqlkiAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPL 265
Cdd:COG1196   507 LEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALE-------AALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPL 579
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 266 LDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKT 345
Cdd:COG1196   580 DKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAG 659
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 346 LETAGYVKSVLERDKLLRFRKQRKKMAKLpkpvvvetffgYDEEASLESDGSSVSYQTDRTDQtpctpDDDLEEGMAKEE 425
Cdd:COG1196   660 GSLTGGSRRELLAALLEAEAELEELAERL-----------AEEELELEEALLAEEEEERELAE-----AEEERLEEELEE 723
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 426 TELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEK--ALAeqgqdmkwIEEKQALYR 503
Cdd:COG1196   724 EALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEALGPvnLLA--------IEEYEELEE 795
                         490       500
                  ....*....|....*....|
gi 1972711434 504 RNQELVEKIKQMETEEARLR 523
Cdd:COG1196   796 RYDFLSEQREDLEEARETLE 815
PTZ00121 PTZ00121
MAEBL; Provisional
41-287 5.01e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 5.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434   41 QEKSKVS---KVEREKNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAvretllRQHEAELLRVIKIKDNENQRLQ 117
Cdd:PTZ00121  1561 EEKKKAEeakKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEA------KKAEEAKIKAEELKKAEEEKKK 1634
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  118 alLSALRDGGPEKVKTVllseakEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLviQADKIKAAEIRSVYHLHQEEI 197
Cdd:PTZ00121  1635 --VEQLKKKEAEEKKKA------EELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKA--EEDEKKAAEALKKEAEEAKKA 1704
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  198 TRIKKECEREIRRLEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSE-ERNELLKRVREAESQYKPLLDKNKRLSRKN 276
Cdd:PTZ00121  1705 EELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEeEKKKIAHLKKEEEKKAEEIRKEKEAVIEEE 1784
                          250
                   ....*....|.
gi 1972711434  277 EDLSHALRRME 287
Cdd:PTZ00121  1785 LDEEDEKRRME 1795
PTZ00121 PTZ00121
MAEBL; Provisional
1-309 1.37e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434    1 MSKRGMSSRAKGDKAEALAALQAANEDLR-AKLTDIQIELQQEKSKVSKVEREKNQELR---QVREHEQHKTAVLLTELK 76
Cdd:PTZ00121  1488 AKKKAEEAKKKADEAKKAAEAKKKADEAKkAEEAKKADEAKKAEEAKKADEAKKAEEKKkadELKKAEELKKAEEKKKAE 1567
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434   77 TKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQAllSALRDGGPEKVKTVLLSEAkEEAKKGFEVEKVKMQQ 156
Cdd:PTZ00121  1568 EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKA--EEAKKAEEAKIKAEELKKA-EEEKKKVEQLKKKEAE 1644
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  157 EISELKGAKRQVEEaltlviqaDKIKAAEIRSVYHLHQEEITRIKKECEREIRRLEQQLDEKDARRfqlKIAELsaiiRK 236
Cdd:PTZ00121  1645 EKKKAEELKKAEEE--------NKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAK---KAEEL----KK 1709
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1972711434  237 LEdrnallsEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENKLKFVTQENIEMRQRAGIIRR 309
Cdd:PTZ00121  1710 KE-------AEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRK 1775
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
26-264 1.99e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  26 EDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVREHEQhktAVLLTELKTKLHEEKMKELQAVretlLRQHEAELLRV 105
Cdd:COG4942    23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER---RIAALARRIRALEQELAALEAE----LAELEKEIAEL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 106 IKIKDNENQRLQALLSAL-RDGGPEKVKTVLLSEAKEEAkkgfevekVKMQQEISELKGAKRQVEEALTLVIQADKIKAA 184
Cdd:COG4942    96 RAELEAQKEELAELLRALyRLGRQPPLALLLSPEDFLDA--------VRRLQYLKYLAPARREQAEELRADLAELAALRA 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 185 EIRSvyhlHQEEITRIKKECEREIRRLEQQLDEKdarrfQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKP 264
Cdd:COG4942   168 ELEA----ERAELEALLAELEEERAALEALKAER-----QKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
424-548 2.71e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 2.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  424 EETELRFRQLTMEYQALQRAYALLQEQvggtLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWI----EEKQ 499
Cdd:COG4913    620 AELEEELAEAEERLEALEAELDALQER----REALQRLAEYSWDEIDVASAEREIAELEAELERLDASSDDLaaleEQLE 695
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1972711434  500 ALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERER 548
Cdd:COG4913    696 ELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLAR 744
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
423-747 3.07e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 3.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  423 KEETELRFRQLTMEYQALQRAYALLQEQVggtldaEREVKTREQLQAEVQRAQARIEDLEKALAEQGqdmkwiEEKQALY 502
Cdd:TIGR02168  220 AELRELELALLVLRLEELREELEELQEEL------KEAEEELEELTAELQELEEKLEELRLEVSELE------EEIEELQ 287
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  503 RRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAISfhhTPFVDGKSPLQVYCEAEgvtdivVA 582
Cdd:TIGR02168  288 KELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEEL---AELEEKLEELKEELESL------EA 358
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  583 ELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEkwlQQIEETEAALQRkmvdLESEKELFSKQKGYLDEELDYRKQALD 662
Cdd:TIGR02168  359 ELEELEAELEELESRLEELEEQLETLRSKVAQLE---LQIASLNNEIER----LEARLERLEDRRERLQQEIEELLKKLE 431
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  663 QANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQvmseLRERDAQILRERMELLQLAQQRIKELEER 742
Cdd:TIGR02168  432 EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALD----AAERELAQLQARLDSLERLQENLEGFSEG 507

                   ....*
gi 1972711434  743 IEAQK 747
Cdd:TIGR02168  508 VKALL 512
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
136-347 3.46e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 3.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  136 LSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEAltlvIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRLEQ-- 213
Cdd:TIGR02169  203 LRREREKAERYQALLKEKREYEGYELLKEKEALERQ----KEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEEln 278
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  214 ----QLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRMENK 289
Cdd:TIGR02169  279 kkikDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEE 358
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1972711434  290 LKFVTQENIEMRQRAGIIRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSKTLE 347
Cdd:TIGR02169  359 YAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQ 416
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
456-545 4.07e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 40.61  E-value: 4.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 456 DAEREVKTRE--QLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELV----EKIKQMETEEARLRHEVQDA 529
Cdd:COG2433   405 ERELTEEEEEirRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEERREirkdREISRLDREIERLERELEEE 484
                          90
                  ....*....|....*.
gi 1972711434 530 RDQNELLEFRILELEE 545
Cdd:COG2433   485 RERIEELKRKLERLKE 500
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
416-750 4.70e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.52  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 416 DLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGgtlDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWI 495
Cdd:COG4717   113 ELREELEKLEKLLQLLPLYQELEALEAELAELPERLE---ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLA 189
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 496 EEKQA--LYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKS------PAISFHHTPFVDGKSPL 567
Cdd:COG4717   190 TEEELqdLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKearlllLIAAALLALLGLGGSLL 269
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 568 QVYCEAEGVTDIVVAELMKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIeeteaaLQRKMVDLESEKELFSKQK 647
Cdd:COG4717   270 SLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEEL------LAALGLPPDLSPEELLELL 343
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 648 GYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSE-----EEREKLKVAVEQWKRQVMSELRER----D 718
Cdd:COG4717   344 DRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAaleqaEEYQELKEELEELEEQLEELLGELeellE 423
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1972711434 719 AQILRERMELLQLAQQRIKELEERIEAQKRQI 750
Cdd:COG4717   424 ALDEEELEEELEELEEELEELEEELEELREEL 455
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
136-302 7.40e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 39.84  E-value: 7.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 136 LSEAKEEAKKGFEVEKVKmqqeISELKGAkrQVEEALTLVIQADKikaAEIRSVYHLHQEEITRIKKECEREIRRLEQQL 215
Cdd:COG2433   352 FERVEKKVPPDVDRDEVK----ARVIRGL--SIEEALEELIEKEL---PEEEPEAEREKEHEERELTEEEEEIRRLEEQV 422
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 216 D--EKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRVREAesqykplldknKRLSRKNEDLSHALRRMENKLKFV 293
Cdd:COG2433   423 ErlEAEVEELEAELEEKDERIERLERELSEARSEERREIRKDREI-----------SRLDREIERLERELEEERERIEEL 491

                  ....*....
gi 1972711434 294 TQENIEMRQ 302
Cdd:COG2433   492 KRKLERLKE 500
PTZ00121 PTZ00121
MAEBL; Provisional
50-549 8.56e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 8.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434   50 EREKNQELRQVREHEQHKTAVLLTELKTKLHEEKMKELQAVRETllRQHEAELLRVIKIKDNENQRlqallsALRDGGPE 129
Cdd:PTZ00121  1192 ELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEA--KKDAEEAKKAEEERNNEEIR------KFEEARMA 1263
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  130 KVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGA--KRQVEEALTLViqADKIKAAEIRSVYHLHQEEITRIKKECERE 207
Cdd:PTZ00121  1264 HFARRQAAIKAEEARKADELKKAEEKKKADEAKKAeeKKKADEAKKKA--EEAKKADEAKKKAEEAKKKADAAKKKAEEA 1341
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  208 IRRLEQQLDEKDARRFQLKIAELSAIIRKLEDRNAllsEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLshalrrme 287
Cdd:PTZ00121  1342 KKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEA---KKKADAAKKKAEEKKKADEAKKKAEEDKKKADEL-------- 1410
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  288 NKLKFVTQENIEMRQRAGIIRRPSSLNdlDQSQDEREVDFLKLQiVEQQNLIDELSKTLETAGYVKSVLERDKLLRFRKQ 367
Cdd:PTZ00121  1411 KKAAAAKKKADEAKKKAEEKKKADEAK--KKAEEAKKADEAKKK-AEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADE 1487
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  368 RKKMAKLPKPVVVETffGYDEEASLESDGSSVSYQTDRTDQTPCTPDDDLEEGMAKEET-----ELRFRQLTMEYQALQR 442
Cdd:PTZ00121  1488 AKKKAEEAKKKADEA--KKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEkkkadELKKAEELKKAEEKKK 1565
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  443 AYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQEL---VEKIKQMETEE 519
Cdd:PTZ00121  1566 AEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEkkkVEQLKKKEAEE 1645
                          490       500       510
                   ....*....|....*....|....*....|
gi 1972711434  520 ARLRHEVQDARDQNELLEFRILELEERERK 549
Cdd:PTZ00121  1646 KKKAEELKKAEEENKIKAAEEAKKAEEDKK 1675
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
31-298 8.74e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 39.53  E-value: 8.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434  31 KLTDIQIELQQEKSKVSKVEREKNQELRQVREHEqhkTAVLLTELKTKlhEEKMKELqavrETLLRQHEAELLRVIKIKD 110
Cdd:PRK05771   61 KLRSYLPKLNPLREEKKKVSVKSLEELIKDVEEE---LEKIEKEIKEL--EEEISEL----ENEIKELEQEIERLEPWGN 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 111 nenqrLQALLSALRDGGPEKVKTVLLSEAKEEAKKgfEVEKVKMQQEISELKGAKrqveealTLVIQADKIKAAEIrsvy 190
Cdd:PRK05771  132 -----FDLDLSLLLGFKYVSVFVGTVPEDKLEELK--LESDVENVEYISTDKGYV-------YVVVVVLKELSDEV---- 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972711434 191 hlhqeeitrikkecEREIRRLEqqldekdARRFQLK-IAELSAIIRKLEDRNALLSEERNELLKRVREAESQYkplldkN 269
Cdd:PRK05771  194 --------------EEELKKLG-------FERLELEeEGTPSELIREIKEELEEIEKERESLLEELKELAKKY------L 246
                         250       260
                  ....*....|....*....|....*....
gi 1972711434 270 KRLSRKNEDLSHALRRMENKLKFVTQENI 298
Cdd:PRK05771  247 EELLALYEYLEIELERAEALSKFLKTDKT 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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