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Conserved domains on  [gi|1972290753|ref|NP_001380002|]
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BAG domain-containing protein [Caenorhabditis elegans]

Protein Classification

BAG family molecular chaperone regulator( domain architecture ID 10644980)

BAG (Bcl-2 associated athanogene) family molecular chaperone regulator which may function as a co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses; similar to Homo sapiens BAG family molecular chaperone regulators

CATH:  1.20.58.120
Gene Ontology:  GO:0051087|GO:0006457
PubMed:  12406544
SCOP:  4002965

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 369-449 9.63e-18

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


:

Pssm-ID: 214591  Cd Length: 79  Bit Score: 77.73  E-value: 9.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972290753  369 ALEDATLMIDEVGEMMHSNIEKAKLCLQTYMNACSYEETAGATCQNFLKIIIQCaaDDQKRIKRRLENLMSQIENAERTK 448
Cdd:smart00264   1 SIKKINEVLDEVQKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGC--EDIREARKRLVRLIQNLLNALDSK 78


                   .
gi 1972290753  449 A 449
Cdd:smart00264  79 K 79
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 274-451 4.29e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 4.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972290753  274 KLQRNQSVVDFNAKTiVTLDKIELQVEQLRKKAAELEMEKEQILRSLGEISVhncmfKLEECDReEIEAITDRLtKRTKT 353
Cdd:TIGR02168  245 QEELKEAEEELEELT-AELQELEEKLEELRLEVSELEEEIEELQKELYALAN-----EISRLEQ-QKQILRERL-ANLER 316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972290753  354 VQVVVETPRNEEQKKALEDATLMIDevgemmhsnIEKAKLCLQTYMNACSYE-ETAGATCQNFLKIIIQC------AADD 426
Cdd:TIGR02168  317 QLEELEAQLEELESKLDELAEELAE---------LEEKLEELKEELESLEAElEELEAELEELESRLEELeeqletLRSK 387

                          170       180
                   ....*....|....*....|....*
gi 1972290753  427 QKRIKRRLENLMSQIENAERTKADL 451
Cdd:TIGR02168  388 VAQLELQIASLNNEIERLEARLERL 412
 
Name Accession Description Interval E-value
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 369-449 9.63e-18

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 77.73  E-value: 9.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972290753  369 ALEDATLMIDEVGEMMHSNIEKAKLCLQTYMNACSYEETAGATCQNFLKIIIQCaaDDQKRIKRRLENLMSQIENAERTK 448
Cdd:smart00264   1 SIKKINEVLDEVQKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGC--EDIREARKRLVRLIQNLLNALDSK 78


                   .
gi 1972290753  449 A 449
Cdd:smart00264  79 K 79
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 274-451 4.29e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 4.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972290753  274 KLQRNQSVVDFNAKTiVTLDKIELQVEQLRKKAAELEMEKEQILRSLGEISVhncmfKLEECDReEIEAITDRLtKRTKT 353
Cdd:TIGR02168  245 QEELKEAEEELEELT-AELQELEEKLEELRLEVSELEEEIEELQKELYALAN-----EISRLEQ-QKQILRERL-ANLER 316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972290753  354 VQVVVETPRNEEQKKALEDATLMIDevgemmhsnIEKAKLCLQTYMNACSYE-ETAGATCQNFLKIIIQC------AADD 426
Cdd:TIGR02168  317 QLEELEAQLEELESKLDELAEELAE---------LEEKLEELKEELESLEAElEELEAELEELESRLEELeeqletLRSK 387

                          170       180
                   ....*....|....*....|....*
gi 1972290753  427 QKRIKRRLENLMSQIENAERTKADL 451
Cdd:TIGR02168  388 VAQLELQIASLNNEIERLEARLERL 412
 
Name Accession Description Interval E-value
BAG smart00264
BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated ...
 369-449 9.63e-18

BAG domains, present in regulator of Hsp70 proteins; BAG domains, present in Bcl-2-associated athanogene 1 and silencer of death domains


Pssm-ID: 214591  Cd Length: 79  Bit Score: 77.73  E-value: 9.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972290753  369 ALEDATLMIDEVGEMMHSNIEKAKLCLQTYMNACSYEETAGATCQNFLKIIIQCaaDDQKRIKRRLENLMSQIENAERTK 448
Cdd:smart00264   1 SIKKINEVLDEVQKKIEKEVQVADGKKDDKEYLRLSEELMKLLLKLDSVDVEGC--EDIREARKRLVRLIQNLLNALDSK 78


                   .
gi 1972290753  449 A 449
Cdd:smart00264  79 K 79
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 274-451 4.29e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 4.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972290753  274 KLQRNQSVVDFNAKTiVTLDKIELQVEQLRKKAAELEMEKEQILRSLGEISVhncmfKLEECDReEIEAITDRLtKRTKT 353
Cdd:TIGR02168  245 QEELKEAEEELEELT-AELQELEEKLEELRLEVSELEEEIEELQKELYALAN-----EISRLEQ-QKQILRERL-ANLER 316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972290753  354 VQVVVETPRNEEQKKALEDATLMIDevgemmhsnIEKAKLCLQTYMNACSYE-ETAGATCQNFLKIIIQC------AADD 426
Cdd:TIGR02168  317 QLEELEAQLEELESKLDELAEELAE---------LEEKLEELKEELESLEAElEELEAELEELESRLEELeeqletLRSK 387

                          170       180
                   ....*....|....*....|....*
gi 1972290753  427 QKRIKRRLENLMSQIENAERTKADL 451
Cdd:TIGR02168  388 VAQLELQIASLNNEIERLEARLERL 412
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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