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Conserved domains on  [gi|1973972391|ref|NP_001380297|]
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CCR4-NOT transcription complex subunit 10 isoform 6 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TPR super family cl33886
Tetratricopeptide (TPR) repeat [General function prediction only];
248-404 6.75e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


The actual alignment was detected with superfamily member COG0457:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973972391 248 NSAPSLFLKSNFEYLRGNYRKAVKLLNSSnIAEHPGFMKTgeclrcmfWNNLGCIHFAMSKHNLGIFYFKKALQENDNVc 327
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKA-LELDPDDAEA--------LYNLGLAYLRLGRYEEALADYEQALELDPDD- 75
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1973972391 328 aqlsagstdpgkkfsgrpmctlltnkrYELLYNCGIQLLHIGRPLAAFECLIEAVQVYHANPRLWLRLAECCIAANK 404
Cdd:COG0457    76 ---------------------------AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
248-404 6.75e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973972391 248 NSAPSLFLKSNFEYLRGNYRKAVKLLNSSnIAEHPGFMKTgeclrcmfWNNLGCIHFAMSKHNLGIFYFKKALQENDNVc 327
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKA-LELDPDDAEA--------LYNLGLAYLRLGRYEEALADYEQALELDPDD- 75
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1973972391 328 aqlsagstdpgkkfsgrpmctlltnkrYELLYNCGIQLLHIGRPLAAFECLIEAVQVYHANPRLWLRLAECCIAANK 404
Cdd:COG0457    76 ---------------------------AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
248-404 6.75e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973972391 248 NSAPSLFLKSNFEYLRGNYRKAVKLLNSSnIAEHPGFMKTgeclrcmfWNNLGCIHFAMSKHNLGIFYFKKALQENDNVc 327
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKA-LELDPDDAEA--------LYNLGLAYLRLGRYEEALADYEQALELDPDD- 75
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1973972391 328 aqlsagstdpgkkfsgrpmctlltnkrYELLYNCGIQLLHIGRPLAAFECLIEAVQVYHANPRLWLRLAECCIAANK 404
Cdd:COG0457    76 ---------------------------AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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