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Conserved domains on  [gi|1989874324|ref|NP_001380490|]
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myocyte-specific enhancer factor 2A isoform 14 [Homo sapiens]

Protein Classification

MADS-box domain-containing protein( domain architecture ID 734)

MADS (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor)-box domain-containing protein functions as a transcription factor and may be involved in various important aspects of development and differentiation

CATH:  3.40.1810.10
Gene Ontology:  GO:0003700|GO:0046983
PubMed:  8875863|29802068|12949148
SCOP:  4001594

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADS super family cl00109
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 2-20 7.63e-04

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


The actual alignment was detected with superfamily member smart00432:

Pssm-ID: 469617 [Multi-domain]  Cd Length: 59  Bit Score: 36.77  E-value: 7.63e-04
                           10
                   ....*....|....*....
gi 1989874324    2 GRKKIQITRIMDERNRQNT 20
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVT 19
 
Name Accession Description Interval E-value
MADS smart00432
MADS domain;
2-20 7.63e-04

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 36.77  E-value: 7.63e-04
                           10
                   ....*....|....*....
gi 1989874324    2 GRKKIQITRIMDERNRQNT 20
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVT 19
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 2-20 3.48e-03

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 35.22  E-value: 3.48e-03
                          10
                  ....*....|....*....
gi 1989874324   2 GRKKIQITRIMDERNRQNT 20
Cdd:cd00265     1 GRGKIEIKRIENSTNRQVT 19
 
Name Accession Description Interval E-value
MADS smart00432
MADS domain;
2-20 7.63e-04

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 36.77  E-value: 7.63e-04
                           10
                   ....*....|....*....
gi 1989874324    2 GRKKIQITRIMDERNRQNT 20
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVT 19
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 2-20 3.48e-03

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 35.22  E-value: 3.48e-03
                          10
                  ....*....|....*....
gi 1989874324   2 GRKKIQITRIMDERNRQNT 20
Cdd:cd00265     1 GRGKIEIKRIENSTNRQVT 19
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 2-20 6.67e-03

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 34.03  E-value: 6.67e-03
                          10
                  ....*....|....*....
gi 1989874324   2 GRKKIQITRIMDERNRQNT 20
Cdd:cd00120     1 GRGKIEIKRIENKTSRQVT 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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