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Conserved domains on  [gi|1992515673|ref|NP_001380535|]
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apolipoprotein L3 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ApoL super family cl20075
Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central ...
 1-191 2.72e-91

Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.


The actual alignment was detected with superfamily member pfam05461:

Pssm-ID: 461657  Cd Length: 298  Bit Score: 269.14  E-value: 2.72e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992515673   1 MSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSL 80
Cdd:pfam05461 102 LTILGLALAPVTAGGSLVLSATGLGLGAAAAVTGVSTSIVEHSSNSSAEAEASRLVSTSTDKLKVVAEVLGGITPKVLSL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992515673  81 LNNYYEATQTIGSEIRAIRQARARARL------PVTTWRISAGSGGQAERTIAGTTRAVSRGARILSATTSGIFLALDVV 154
Cdd:pfam05461 182 ALDCIQVLKGIGKNIRAIRLAKANPRLvasakrFMTTGRISAQSGKQVQRAFGGTALAMSKGARIMGAATAGVFLLLDVV 261

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1992515673 155 NLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQ 191
Cdd:pfam05461 262 SLVKESKHLHEGAKSESAEELRQQAQELEEKLEELTQ 298
 
Name Accession Description Interval E-value
ApoL pfam05461
Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central ...
 1-191 2.72e-91

Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.


Pssm-ID: 461657  Cd Length: 298  Bit Score: 269.14  E-value: 2.72e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992515673   1 MSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSL 80
Cdd:pfam05461 102 LTILGLALAPVTAGGSLVLSATGLGLGAAAAVTGVSTSIVEHSSNSSAEAEASRLVSTSTDKLKVVAEVLGGITPKVLSL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992515673  81 LNNYYEATQTIGSEIRAIRQARARARL------PVTTWRISAGSGGQAERTIAGTTRAVSRGARILSATTSGIFLALDVV 154
Cdd:pfam05461 182 ALDCIQVLKGIGKNIRAIRLAKANPRLvasakrFMTTGRISAQSGKQVQRAFGGTALAMSKGARIMGAATAGVFLLLDVV 261

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1992515673 155 NLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQ 191
Cdd:pfam05461 262 SLVKESKHLHEGAKSESAEELRQQAQELEEKLEELTQ 298
 
Name Accession Description Interval E-value
ApoL pfam05461
Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central ...
 1-191 2.72e-91

Apolipoprotein L; Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.


Pssm-ID: 461657  Cd Length: 298  Bit Score: 269.14  E-value: 2.72e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992515673   1 MSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSL 80
Cdd:pfam05461 102 LTILGLALAPVTAGGSLVLSATGLGLGAAAAVTGVSTSIVEHSSNSSAEAEASRLVSTSTDKLKVVAEVLGGITPKVLSL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992515673  81 LNNYYEATQTIGSEIRAIRQARARARL------PVTTWRISAGSGGQAERTIAGTTRAVSRGARILSATTSGIFLALDVV 154
Cdd:pfam05461 182 ALDCIQVLKGIGKNIRAIRLAKANPRLvasakrFMTTGRISAQSGKQVQRAFGGTALAMSKGARIMGAATAGVFLLLDVV 261

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1992515673 155 NLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQ 191
Cdd:pfam05461 262 SLVKESKHLHEGAKSESAEELRQQAQELEEKLEELTQ 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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