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Conserved domains on  [gi|2017363570|ref|NP_001380863|]
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POU domain, class 2, transcription factor 2 isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
288-362 9.18e-47

Found in Pit-Oct-Unc transcription factors;


:

Pssm-ID: 197673  Cd Length: 75  Bit Score: 159.91  E-value: 9.18e-47
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017363570  288 EEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAE 362
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
391-447 2.02e-21

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.94  E-value: 2.02e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2017363570 391 RKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKR 447
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
POU2F1_C super family cl44948
POU domain, class 2, transcription factor 1 C-terminal; This domain represents the C-terminal ...
 565-641 5.83e-20

POU domain, class 2, transcription factor 1 C-terminal; This domain represents the C-terminal region of the POU domain, class 2 subfamily, transcription factor 1, which is localized adjacent to the homeobox domain. This transcription factor activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins.


The actual alignment was detected with superfamily member pfam19536:

Pssm-ID: 437368  Cd Length: 284  Bit Score: 90.69  E-value: 5.83e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2017363570 565 GLSSGLSPALMSNNPLATIQALASGGTLPLTSLDGSGNLVLgAAGAAPGSPGLVTSPLFLNHAGLPLLSTPPgVGLV 641
Cdd:pfam19536 173 GLGGALSPALMSNSTLATIQALASSGTLPITSLDGSGNLLF-ANTSAGGTPNLVTAPLFLNPQNLSLLTSNP-VSLV 247
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
288-362 9.18e-47

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 159.91  E-value: 9.18e-47
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017363570  288 EEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAE 362
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
292-362 9.47e-42

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 145.88  E-value: 9.47e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017363570 292 DLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAE 362
Cdd:pfam00157   2 NLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
391-447 2.02e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.94  E-value: 2.02e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2017363570 391 RKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKR 447
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
POU2F1_C pfam19536
POU domain, class 2, transcription factor 1 C-terminal; This domain represents the C-terminal ...
 565-641 5.83e-20

POU domain, class 2, transcription factor 1 C-terminal; This domain represents the C-terminal region of the POU domain, class 2 subfamily, transcription factor 1, which is localized adjacent to the homeobox domain. This transcription factor activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins.


Pssm-ID: 437368  Cd Length: 284  Bit Score: 90.69  E-value: 5.83e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2017363570 565 GLSSGLSPALMSNNPLATIQALASGGTLPLTSLDGSGNLVLgAAGAAPGSPGLVTSPLFLNHAGLPLLSTPPgVGLV 641
Cdd:pfam19536 173 GLGGALSPALMSNSTLATIQALASSGTLPITSLDGSGNLLF-ANTSAGGTPNLVTAPLFLNPQNLSLLTSNP-VSLV 247
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 390-446 5.67e-17

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 75.36  E-value: 5.67e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2017363570  390 RRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEK 446
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 391-447 1.05e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 74.59  E-value: 1.05e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2017363570 391 RKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKR 447
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
331-449 1.82e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.84  E-value: 1.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363570 331 QTTISRFEALNLSFKNMCKLkpllEKWLNDAETMSVDSSLpspnqlsSPSLGFDGLPGRRRKKRTSIETNVrfaLEKSFL 410
Cdd:COG5576     6 MQPLSALESQRMPQIRTIKT----TKNKREVEAADSEMKL-------ERKQDGSSPPKSKRRRTTDEQLMV---LEREFE 71

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2017363570 411 ANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRIN 449
Cdd:COG5576    72 INPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
288-362 9.18e-47

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 159.91  E-value: 9.18e-47
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2017363570  288 EEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAE 362
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
292-362 9.47e-42

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 145.88  E-value: 9.47e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017363570 292 DLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAE 362
Cdd:pfam00157   2 NLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
391-447 2.02e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.94  E-value: 2.02e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2017363570 391 RKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKR 447
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
POU2F1_C pfam19536
POU domain, class 2, transcription factor 1 C-terminal; This domain represents the C-terminal ...
 565-641 5.83e-20

POU domain, class 2, transcription factor 1 C-terminal; This domain represents the C-terminal region of the POU domain, class 2 subfamily, transcription factor 1, which is localized adjacent to the homeobox domain. This transcription factor activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins.


Pssm-ID: 437368  Cd Length: 284  Bit Score: 90.69  E-value: 5.83e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2017363570 565 GLSSGLSPALMSNNPLATIQALASGGTLPLTSLDGSGNLVLgAAGAAPGSPGLVTSPLFLNHAGLPLLSTPPgVGLV 641
Cdd:pfam19536 173 GLGGALSPALMSNSTLATIQALASSGTLPITSLDGSGNLLF-ANTSAGGTPNLVTAPLFLNPQNLSLLTSNP-VSLV 247
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 390-446 5.67e-17

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 75.36  E-value: 5.67e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2017363570  390 RRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEK 446
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 391-447 1.05e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 74.59  E-value: 1.05e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2017363570 391 RKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKR 447
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
331-449 1.82e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.84  E-value: 1.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363570 331 QTTISRFEALNLSFKNMCKLkpllEKWLNDAETMSVDSSLpspnqlsSPSLGFDGLPGRRRKKRTSIETNVrfaLEKSFL 410
Cdd:COG5576     6 MQPLSALESQRMPQIRTIKT----TKNKREVEAADSEMKL-------ERKQDGSSPPKSKRRRTTDEQLMV---LEREFE 71

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2017363570 411 ANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRIN 449
Cdd:COG5576    72 INPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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