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Conserved domains on  [gi|2021882773|ref|NP_001381097|]
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eukaryotic translation initiation factor 3 subunit I isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-299 1.98e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.82  E-value: 1.98e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773   5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETG 84
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  85 KQLALLK-TNSAVRTCGFDFGGNIIMF-STDKQmgyqcfVSFFDLRDPSQIDnnepymKIPCNDSKITSAVWGPLGECII 162
Cdd:COG2319   195 KLLRTLTgHTGAVRSVAFSPDGKLLASgSADGT------VRLWDLATGKLLR------TLTGHSGSVRSVAFSPDGRLLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 163 AGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFR-TERPVNSAALSPNY 241
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDG 342

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2021882773 242 DHVVLGGGQEAmdvtttstrigkfeARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKR 299
Cdd:COG2319   343 KTLASGSDDGT--------------VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT 386
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-299 1.98e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.82  E-value: 1.98e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773   5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETG 84
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  85 KQLALLK-TNSAVRTCGFDFGGNIIMF-STDKQmgyqcfVSFFDLRDPSQIDnnepymKIPCNDSKITSAVWGPLGECII 162
Cdd:COG2319   195 KLLRTLTgHTGAVRSVAFSPDGKLLASgSADGT------VRLWDLATGKLLR------TLTGHSGSVRSVAFSPDGRLLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 163 AGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFR-TERPVNSAALSPNY 241
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDG 342

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2021882773 242 DHVVLGGGQEAmdvtttstrigkfeARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKR 299
Cdd:COG2319   343 KTLASGSDDGT--------------VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT 386
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-299 6.17e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 6.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773   6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGK 85
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  86 QLALLKT-NSAVRTCgfdfggniiMFSTDKQM----GYQCFVSFFDLRDPSQIdnnepyMKIPCNDSKITSAVWGPLGEC 160
Cdd:cd00200    85 CVRTLTGhTSYVSSV---------AFSPDGRIlsssSRDKTIKVWDVETGKCL------TTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 161 IIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRT-ERPVNSAALSP 239
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 240 NYDHVVLGggqeAMDVTTtstrigkfeaRFFHLAFEEEFGRVKGHFGPINSVAFHPDGKR 299
Cdd:cd00200   230 DGYLLASG----SEDGTI----------RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275
WD40 pfam00400
WD domain, G-beta repeat;
42-80 2.05e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 2.05e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2021882773  42 GERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWD 80
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-80 2.29e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 2.29e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2021882773   41 NGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWD 80
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 31-216 1.59e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  31 DPIVNVWySVNGERLGTYMG-HTGAVWCVD-ADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGF--DFGGN 106
Cdd:PLN00181  554 EGVVQVW-DVARSQLVTEMKeHEKRVWSIDySSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpsESGRS 632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 107 IIMFSTDKQmgyqcfVSFFDLRDPsqidnnepymKIPCndskitsavwgplgeCIIAGhesgelnqysaksgevlvnvke 186
Cdd:PLN00181  633 LAFGSADHK------VYYYDLRNP----------KLPL---------------CTMIG---------------------- 659

                         170       180       190
                  ....*....|....*....|....*....|
gi 2021882773 187 HSRQINDIQLSrDMTMFVTASKDNTAKLFD 216
Cdd:PLN00181  660 HSKTVSYVRFV-DSSTLVSSSTDNTLKLWD 688
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-299 1.98e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.82  E-value: 1.98e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773   5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETG 84
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  85 KQLALLK-TNSAVRTCGFDFGGNIIMF-STDKQmgyqcfVSFFDLRDPSQIDnnepymKIPCNDSKITSAVWGPLGECII 162
Cdd:COG2319   195 KLLRTLTgHTGAVRSVAFSPDGKLLASgSADGT------VRLWDLATGKLLR------TLTGHSGSVRSVAFSPDGRLLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 163 AGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFR-TERPVNSAALSPNY 241
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDG 342

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2021882773 242 DHVVLGGGQEAmdvtttstrigkfeARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKR 299
Cdd:COG2319   343 KTLASGSDDGT--------------VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT 386
WD40 COG2319
WD40 repeat [General function prediction only];
6-299 2.91e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.96  E-value: 2.91e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773   6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGK 85
Cdd:COG2319    74 LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  86 QLALLKTNSAVRTCgfdfggniIMFSTDKQM----GYQCFVSFFDLRDPSQIDNnepymkIPCNDSKITSAVWGPLGECI 161
Cdd:COG2319   154 LLRTLTGHSGAVTS--------VAFSPDGKLlasgSDDGTVRLWDLATGKLLRT------LTGHTGAVRSVAFSPDGKLL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 162 IAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRT-ERPVNSAALSPN 240
Cdd:COG2319   220 ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPD 299

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2021882773 241 YDHVVLGGGqeamDVTttstrigkfeARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKR 299
Cdd:COG2319   300 GKLLASGSD----DGT----------VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKT 344
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-299 6.17e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 6.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773   6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGK 85
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  86 QLALLKT-NSAVRTCgfdfggniiMFSTDKQM----GYQCFVSFFDLRDPSQIdnnepyMKIPCNDSKITSAVWGPLGEC 160
Cdd:cd00200    85 CVRTLTGhTSYVSSV---------AFSPDGRIlsssSRDKTIKVWDVETGKCL------TTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 161 IIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRT-ERPVNSAALSP 239
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 240 NYDHVVLGggqeAMDVTTtstrigkfeaRFFHLAFEEEFGRVKGHFGPINSVAFHPDGKR 299
Cdd:cd00200   230 DGYLLASG----SEDGTI----------RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275
WD40 COG2319
WD40 repeat [General function prediction only];
5-299 2.93e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.87  E-value: 2.93e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773   5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETG 84
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  85 KQLALLK-TNSAVRTCGFDFGGNIIMF-STDKQmgyqcfVSFFDLRDPSQIDNnepymkIPCNDSKITSAVWGPLGECII 162
Cdd:COG2319   111 LLLRTLTgHTGAVRSVAFSPDGKTLASgSADGT------VRLWDLATGKLLRT------LTGHSGAVTSVAFSPDGKLLA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 163 AGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRT-ERPVNSAALSPNY 241
Cdd:COG2319   179 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDG 258

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2021882773 242 DHVVLGGGqeamDVTttstrigkfeARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKR 299
Cdd:COG2319   259 RLLASGSA----DGT----------VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL 302
WD40 COG2319
WD40 repeat [General function prediction only];
6-249 2.67e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.17  E-value: 2.67e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773   6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGK 85
Cdd:COG2319   158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  86 QLALLKT-NSAVRTCGFDFGGNIIMF-STDKQmgyqcfVSFFDLRDPSQIDnnepymKIPCNDSKITSAVWGPLGECIIA 163
Cdd:COG2319   238 LLRTLTGhSGSVRSVAFSPDGRLLASgSADGT------VRLWDLATGELLR------TLTGHSGGVNSVAFSPDGKLLAS 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 164 GHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRT-ERPVNSAALSPNYD 242
Cdd:COG2319   306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGR 385


                  ....*..
gi 2021882773 243 HVVLGGG 249
Cdd:COG2319   386 TLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-245 2.04e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 2.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773   6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGK 85
Cdd:cd00200    47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  86 QLALLKT-NSAVRTCGFDFGGNIIM-FSTDKQmgyqcfVSFFDLRdpsqidNNEPYMKIPCNDSKITSAVWGPLGECIIA 163
Cdd:cd00200   127 CLTTLRGhTDWVNSVAFSPDGTFVAsSSQDGT------IKLWDLR------TGKCVATLTGHTGEVNSVAFSPDGEKLLS 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 164 GHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFR-TERPVNSAALSPNYD 242
Cdd:cd00200   195 SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGK 274


                  ...
gi 2021882773 243 HVV 245
Cdd:cd00200   275 RLA 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-298 1.87e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.81  E-value: 1.87e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  45 LGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNS-AVRTCGF-DFGGNIIMFSTDKQmgyqcfV 122
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgPVRDVAAsADGTYLASGSSDKT------I 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 123 SFFDLRDPSQIDnnepymKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTM 202
Cdd:cd00200    76 RLWDLETGECVR------TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 203 FVTASKDNTAKLFDSTTLEHQKTFRT-ERPVNSAALSPNYDHVVLGGGqeamDVTttstrigkfeARFFHLAFEEEFGRV 281
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSS----DGT----------IKLWDLSTGKCLGTL 215

                         250
                  ....*....|....*..
gi 2021882773 282 KGHFGPINSVAFHPDGK 298
Cdd:cd00200   216 RGHENGVNSVAFSPDGY 232
WD40 COG2319
WD40 repeat [General function prediction only];
6-219 9.99e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 9.99e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773   6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDadW--DTKHVLTGSADNSCRLWDCET 83
Cdd:COG2319   200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA--FspDGRLLASGSADGTVRLWDLAT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  84 GKQLALLKT-NSAVRTCGFDFGGNIIMFSTDKQMgyqcfVSFFDLRDPSQIDNNEPYmkipcnDSKITSAVWGPLGECII 162
Cdd:COG2319   278 GELLRTLTGhSGGVNSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGH------TGAVRSVAFSPDGKTLA 346

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2021882773 163 AGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTT 219
Cdd:COG2319   347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-216 4.62e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 4.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773   6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGK 85
Cdd:cd00200   131 LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  86 QLALLktnsavrtcgfdfggniimfstdkqmgyqcfvsffdlrdpsqidnnepymkiPCNDSKITSAVWGPLGECIIAGH 165
Cdd:cd00200   211 CLGTL----------------------------------------------------RGHENGVNSVAFSPDGYLLASGS 238

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2021882773 166 ESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFD 216
Cdd:cd00200   239 EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
5-108 1.24e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 1.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773   5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETG 84
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG 362

                          90       100
                  ....*....|....*....|....*
gi 2021882773  85 KQLALLKTNS-AVRTCGFDFGGNII 108
Cdd:COG2319   363 ELLRTLTGHTgAVTSVAFSPDGRTL 387
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-80 1.21e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 1.21e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2021882773   5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWD 80
Cdd:cd00200   214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
42-80 2.05e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 2.05e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2021882773  42 GERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWD 80
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-80 2.29e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 2.29e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2021882773   41 NGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWD 80
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-216 1.52e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2021882773  177 SGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFD 216
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 31-216 1.59e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773  31 DPIVNVWySVNGERLGTYMG-HTGAVWCVD-ADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGF--DFGGN 106
Cdd:PLN00181  554 EGVVQVW-DVARSQLVTEMKeHEKRVWSIDySSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpsESGRS 632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2021882773 107 IIMFSTDKQmgyqcfVSFFDLRDPsqidnnepymKIPCndskitsavwgplgeCIIAGhesgelnqysaksgevlvnvke 186
Cdd:PLN00181  633 LAFGSADHK------VYYYDLRNP----------KLPL---------------CTMIG---------------------- 659

                         170       180       190
                  ....*....|....*....|....*....|
gi 2021882773 187 HSRQINDIQLSrDMTMFVTASKDNTAKLFD 216
Cdd:PLN00181  660 HSKTVSYVRFV-DSSTLVSSSTDNTLKLWD 688
WD40 pfam00400
WD domain, G-beta repeat;
178-216 8.53e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 8.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2021882773 178 GEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFD 216
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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