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Conserved domains on  [gi|2025113594|ref|NP_001381258|]
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transcriptional coactivator YAP1 2 [Rattus norvegicus]

Protein Classification

transcriptional coactivator YAP1( domain architecture ID 10078884)

transcriptional coactivator YAP1 can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis

CATH:  2.20.70.10
Gene Ontology:  GO:0005515
PubMed:  22201747|9029943|7641887
SCOP:  3001621

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 213-245 6.62e-11

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


:

Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 56.84  E-value: 6.62e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2025113594  213 PLPDGWEQAMTQDGEVYYINHKNKTTSWLDPRL 245
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPRE 33
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 156-185 1.02e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


:

Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 56.38  E-value: 1.02e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 2025113594 156 PAGWEMAKTSSGQRYFLNHNDQTTTWQDPR 185
Cdd:cd00201     1 PPGWEERWDPDGRVYYYNHNTKETQWEDPR 30
 
Name Accession Description Interval E-value
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 213-245 6.62e-11

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 56.84  E-value: 6.62e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2025113594  213 PLPDGWEQAMTQDGEVYYINHKNKTTSWLDPRL 245
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPRE 33
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 214-243 9.43e-11

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 56.36  E-value: 9.43e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 2025113594 214 LPDGWEQAMTQDGEVYYINHKNKTTSWLDP 243
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 156-185 1.02e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 56.38  E-value: 1.02e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 2025113594 156 PAGWEMAKTSSGQRYFLNHNDQTTTWQDPR 185
Cdd:cd00201     1 PPGWEERWDPDGRVYYYNHNTKETQWEDPR 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 215-245 1.05e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 56.38  E-value: 1.05e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2025113594 215 PDGWEQAMTQDGEVYYINHKNKTTSWLDPRL 245
Cdd:cd00201     1 PPGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 154-185 1.60e-10

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 55.68  E-value: 1.60e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2025113594  154 PLPAGWEMAKTSSGQRYFLNHNDQTTTWQDPR 185
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPR 32
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 155-184 1.93e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.51  E-value: 1.93e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 2025113594 155 LPAGWEMAKTSSGQRYFLNHNDQTTTWQDP 184
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
155-253 2.91e-07

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 53.23  E-value: 2.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025113594 155 LPAGWEMAKTSSGQRYFLNHNDQTTTWQDPRkamlSQLNVPTSASPAVPQTLMN----SASGPLPDGWEQAMTQDGEVYY 230
Cdd:COG5021   388 KPTGWSSSIEDLGQFLFSDFLTSSSTYEDLR----REQLGRESDESFYVASNVQqqraSREGPLLSGWKTRLNNLYRFYF 463

                          90       100
                  ....*....|....*....|...
gi 2025113594 231 INHKNKTTSWLDPRLDPRFAMNQ 253
Cdd:COG5021   464 VEHRKKTLTKNDSRLGSFISLNK 486
 
Name Accession Description Interval E-value
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 213-245 6.62e-11

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 56.84  E-value: 6.62e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2025113594  213 PLPDGWEQAMTQDGEVYYINHKNKTTSWLDPRL 245
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPRE 33
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 214-243 9.43e-11

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 56.36  E-value: 9.43e-11
                          10        20        30
                  ....*....|....*....|....*....|
gi 2025113594 214 LPDGWEQAMTQDGEVYYINHKNKTTSWLDP 243
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 156-185 1.02e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 56.38  E-value: 1.02e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 2025113594 156 PAGWEMAKTSSGQRYFLNHNDQTTTWQDPR 185
Cdd:cd00201     1 PPGWEERWDPDGRVYYYNHNTKETQWEDPR 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 215-245 1.05e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 56.38  E-value: 1.05e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2025113594 215 PDGWEQAMTQDGEVYYINHKNKTTSWLDPRL 245
Cdd:cd00201     1 PPGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 154-185 1.60e-10

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 55.68  E-value: 1.60e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2025113594  154 PLPAGWEMAKTSSGQRYFLNHNDQTTTWQDPR 185
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPR 32
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 155-184 1.93e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.51  E-value: 1.93e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 2025113594 155 LPAGWEMAKTSSGQRYFLNHNDQTTTWQDP 184
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
155-253 2.91e-07

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 53.23  E-value: 2.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025113594 155 LPAGWEMAKTSSGQRYFLNHNDQTTTWQDPRkamlSQLNVPTSASPAVPQTLMN----SASGPLPDGWEQAMTQDGEVYY 230
Cdd:COG5021   388 KPTGWSSSIEDLGQFLFSDFLTSSSTYEDLR----REQLGRESDESFYVASNVQqqraSREGPLLSGWKTRLNNLYRFYF 463

                          90       100
                  ....*....|....*....|...
gi 2025113594 231 INHKNKTTSWLDPRLDPRFAMNQ 253
Cdd:COG5021   464 VEHRKKTLTKNDSRLGSFISLNK 486
PRP40 COG5104
Splicing factor [RNA processing and modification];
159-243 1.12e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 44.69  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2025113594 159 WEMAKTSSGQRYFLNHNDQTTTWQDPRKamlsqlnvptsaspavpqtLMNSASGPLP-DGWEQAMTQDGEVYYINHKNKT 237
Cdd:COG5104    17 WEELKAPDGRIYYYNKRTGKSSWEKPKE-------------------LLKGSEEDLDvDPWKECRTADGKVYYYNSITRE 77


                  ....*.
gi 2025113594 238 TSWLDP 243
Cdd:COG5104    78 SRWKIP 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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