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Conserved domains on  [gi|2032329410|ref|NP_001381701|]
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COP9 signalosome complex subunit 1 isoform 17 [Homo sapiens]

Protein Classification

COP9 signalosome complex subunit 1( domain architecture ID 10566214)

The COP9 signalosome subunit 1 (CSN1) is an essential component of the CSN complex and is involved in the deubiquitination of target proteins which helps to regulate the stability and activity of a variety of proteins involved in different cellular pathways

Gene Ontology:  GO:0000338|GO:0008180|GO:2000434
PubMed:  27029275|9644972
SCOP:  4000147

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
107-288 8.65e-68

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


:

Pssm-ID: 431387  Cd Length: 174  Bit Score: 214.36  E-value: 8.65e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 107 DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVI 186
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 187 KVSVYLQNWSHVLSYVSKAESTPEIAERGERdsqtqaiLTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDfPELLSPS 266
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGDWER-------RNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS-TELISYE 152
                         170       180
                  ....*....|....*....|..
gi 2032329410 267 NVAIYGGLCALATFDRQELQRN 288
Cdd:pfam10602 153 DVAVYGVLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
303-407 1.52e-22

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


:

Pssm-ID: 460195  Cd Length: 105  Bit Score: 91.89  E-value: 1.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 303 PQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDE 382
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 2032329410 383 LTQLILEGLISARVDSHSKILYARD 407
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
107-288 8.65e-68

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 214.36  E-value: 8.65e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 107 DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVI 186
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 187 KVSVYLQNWSHVLSYVSKAESTPEIAERGERdsqtqaiLTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDfPELLSPS 266
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGDWER-------RNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS-TELISYE 152
                         170       180
                  ....*....|....*....|..
gi 2032329410 267 NVAIYGGLCALATFDRQELQRN 288
Cdd:pfam10602 153 DVAVYGVLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
303-407 1.52e-22

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 91.89  E-value: 1.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 303 PQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDE 382
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 2032329410 383 LTQLILEGLISARVDSHSKILYARD 407
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
RPN7 COG5187
26S proteasome regulatory complex component, contains PCI domain [Posttranslational ...
147-445 4.36e-18

26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227514 [Multi-domain]  Cd Length: 412  Bit Score: 86.12  E-value: 4.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 147 DLGDHYLDCGDLSNALKCYSRA--RDYCTSAKhvINMCLNVIKVSVYLQNWSHVLSYVSKAEStpeIAERG---ERDSqt 221
Cdd:COG5187   120 NIAEYYCQIMDIQNGFEWMRRLmrDAMSTGLK--IDVFLCKIRLGLIYGDRKVVEESLEVADD---IIEKGgdwERRN-- 192
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 222 qailtKLKCAAGLAELAARKYKQAAKCLL--LASFDHCdfpELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFklfL 299
Cdd:COG5187   193 -----RYKVYKGIFKMMRRNFKEAAILLSdiLPTFESS---ELISYSRAVRYAIFCGLLRLERRDIKTKILDSPEV---L 261
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 300 ELEPQ------VRDIIFKFYESKYASCLKMLDEMKDNLLL-DMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAF 372
Cdd:COG5187   262 DVIGSseklgsLVQLATSLYECDYGGDFMNLLYLFCNSLQdDVFLGRHVDLFVREMRRRVYAQLLESYRLLSLESMAQTF 341
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2032329410 373 NTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMlrAAVLRNQIHV 445
Cdd:COG5187   342 GVSVEYVDRDLGEFIPEGRLNCVIDRVNGVVETNRPDEKNQQYSSVVKQGDDLLRKLQKYV--ATVMRGAFKV 412
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
339-422 1.03e-15

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 72.27  E-value: 1.03e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410  339 PHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRS----TT 414
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRseplAQ 80

                   ....*...
gi 2032329410  415 FEKSLLMG 422
Cdd:smart00088  81 FAETLKKL 88
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
107-288 8.65e-68

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 214.36  E-value: 8.65e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 107 DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVI 186
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 187 KVSVYLQNWSHVLSYVSKAESTPEIAERGERdsqtqaiLTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDfPELLSPS 266
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGDWER-------RNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS-TELISYE 152
                         170       180
                  ....*....|....*....|..
gi 2032329410 267 NVAIYGGLCALATFDRQELQRN 288
Cdd:pfam10602 153 DVAVYGVLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
303-407 1.52e-22

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 91.89  E-value: 1.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 303 PQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDE 382
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 2032329410 383 LTQLILEGLISARVDSHSKILYARD 407
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
RPN7 COG5187
26S proteasome regulatory complex component, contains PCI domain [Posttranslational ...
147-445 4.36e-18

26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227514 [Multi-domain]  Cd Length: 412  Bit Score: 86.12  E-value: 4.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 147 DLGDHYLDCGDLSNALKCYSRA--RDYCTSAKhvINMCLNVIKVSVYLQNWSHVLSYVSKAEStpeIAERG---ERDSqt 221
Cdd:COG5187   120 NIAEYYCQIMDIQNGFEWMRRLmrDAMSTGLK--IDVFLCKIRLGLIYGDRKVVEESLEVADD---IIEKGgdwERRN-- 192
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 222 qailtKLKCAAGLAELAARKYKQAAKCLL--LASFDHCdfpELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFklfL 299
Cdd:COG5187   193 -----RYKVYKGIFKMMRRNFKEAAILLSdiLPTFESS---ELISYSRAVRYAIFCGLLRLERRDIKTKILDSPEV---L 261
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410 300 ELEPQ------VRDIIFKFYESKYASCLKMLDEMKDNLLL-DMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAF 372
Cdd:COG5187   262 DVIGSseklgsLVQLATSLYECDYGGDFMNLLYLFCNSLQdDVFLGRHVDLFVREMRRRVYAQLLESYRLLSLESMAQTF 341
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2032329410 373 NTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMlrAAVLRNQIHV 445
Cdd:COG5187   342 GVSVEYVDRDLGEFIPEGRLNCVIDRVNGVVETNRPDEKNQQYSSVVKQGDDLLRKLQKYV--ATVMRGAFKV 412
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
339-422 1.03e-15

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 72.27  E-value: 1.03e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2032329410  339 PHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRS----TT 414
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRseplAQ 80

                   ....*...
gi 2032329410  415 FEKSLLMG 422
Cdd:smart00088  81 FAETLKKL 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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