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Conserved domains on  [gi|2035341177|ref|NP_001381840|]
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latent-transforming growth factor beta-binding protein 1 isoform 12 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 362-403 7.23e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 63.84  E-value: 7.23e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2035341177  362 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 403
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 990-1032 4.11e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.13  E-value: 4.11e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341177  990 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 1032
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1166-1208 2.41e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.82  E-value: 2.41e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341177 1166 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1208
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
833-874 4.04e-08

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.32  E-value: 4.04e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   833 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 874
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
751-791 1.19e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.19e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   751 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 791
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
710-741 3.42e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 3.42e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2035341177   710 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 741
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
875-916 9.04e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 9.04e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   875 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFqapQDGQGCV 916
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
669-708 1.54e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.54e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2035341177   669 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 708
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
300-330 3.68e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.68e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2035341177   300 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 330
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
546-587 4.75e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.75e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2035341177   546 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 587
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
792-822 7.33e-05

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.07  E-value: 7.33e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341177  792 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 822
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1293-1327 3.23e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.23e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2035341177  1293 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1327
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
588-628 6.69e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 6.69e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   588 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 628
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 241-276 9.13e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 38.41  E-value: 9.13e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2035341177  241 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 276
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 629-662 5.15e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 5.15e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2035341177  629 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 662
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 362-403 7.23e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 63.84  E-value: 7.23e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2035341177  362 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 403
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 990-1032 4.11e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.13  E-value: 4.11e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341177  990 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 1032
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1166-1208 2.41e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.82  E-value: 2.41e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341177 1166 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1208
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
833-874 4.04e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.32  E-value: 4.04e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   833 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 874
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 833-874 2.44e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 2.44e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2035341177  833 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 874
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
751-791 1.19e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.19e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   751 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 791
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
710-741 3.42e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 3.42e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2035341177   710 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 741
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 751-791 3.83e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 3.83e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2035341177  751 DIDECQHRHLC-AHGQCRNTEGSFQCVCDQGYRasglGDHCE 791
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 710-742 7.53e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 7.53e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2035341177  710 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 742
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
875-916 9.04e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 9.04e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   875 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFqapQDGQGCV 916
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
669-708 1.54e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.54e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2035341177   669 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 708
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 875-907 2.89e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.89e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2035341177  875 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 907
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
300-330 3.68e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.68e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2035341177   300 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 330
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
546-587 4.75e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.75e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2035341177   546 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 587
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
792-822 7.33e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.07  E-value: 7.33e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341177  792 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 822
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 669-700 9.49e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 9.49e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2035341177  669 DVDECLEPNVCAN-GDCSNLEGSYMCSCHKGYT 700
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 300-330 1.24e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.24e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341177  300 DINECQLQGVCPN-GECLNTMGSYRCTCKIGF 330
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
792-832 1.33e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.33e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   792 DINECLEDkSVCQRG-DCINTAGSYDCTCPDGFQldDNKTCQ 832
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
546-576 2.90e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 2.90e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341177  546 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 576
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1293-1327 3.23e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.23e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2035341177  1293 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1327
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 546-587 5.46e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 5.46e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2035341177  546 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 587
Cdd:cd00054      1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
588-628 6.69e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 6.69e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   588 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 628
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1293-1327 9.02e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 9.02e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2035341177 1293 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1327
Cdd:cd00054      1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 241-276 9.13e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 38.41  E-value: 9.13e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2035341177  241 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 276
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 792-832 1.74e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.74e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2035341177  792 DINEClEDKSVCQR-GDCINTAGSYDCTCPDGFQLddnKTCQ 832
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG---RNCE 38
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 857-878 2.61e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.62  E-value: 2.61e-03
                           10        20
                   ....*....|....*....|..
gi 2035341177  857 HCVCQQGFSISADGRTCEDIDE 878
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA pfam07645
Calcium-binding EGF domain;
875-905 3.10e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.10e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341177  875 DIDECVNNT-VCDSHGFCDNTAGSFRCLCYQG 905
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1293-1326 3.52e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2035341177 1293 DVNECDELNNrmsLC-KNAKCINTDGSYKCLCLPG 1326
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 588-620 4.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 4.49e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2035341177  588 DVDECLRPDVCGEGH-CVNTVGAFRCEyCDSGYR 620
Cdd:cd00054      1 DIDECASGNPCQNGGtCVNTVGSYRCS-CPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 629-662 5.15e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 5.15e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2035341177  629 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 662
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
300-329 5.81e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 5.81e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341177  300 DINEC-QLQGVCP-NGECLNTMGSYRCTCKIG 329
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 362-403 7.23e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 63.84  E-value: 7.23e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2035341177  362 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 403
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 990-1032 4.11e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.13  E-value: 4.11e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341177  990 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 1032
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1166-1208 2.41e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.82  E-value: 2.41e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341177 1166 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1208
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
833-874 4.04e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.32  E-value: 4.04e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   833 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 874
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 833-874 2.44e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 2.44e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2035341177  833 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 874
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
751-791 1.19e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.19e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   751 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 791
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
710-741 3.42e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 3.42e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2035341177   710 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 741
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 751-791 3.83e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 3.83e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2035341177  751 DIDECQHRHLC-AHGQCRNTEGSFQCVCDQGYRasglGDHCE 791
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 710-742 7.53e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 7.53e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2035341177  710 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 742
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
875-916 9.04e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 9.04e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   875 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFqapQDGQGCV 916
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
669-708 1.54e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.54e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2035341177   669 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 708
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 875-907 2.89e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.89e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2035341177  875 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 907
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
300-330 3.68e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.68e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2035341177   300 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 330
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
546-587 4.75e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.75e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2035341177   546 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 587
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
792-822 7.33e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.07  E-value: 7.33e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341177  792 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 822
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 669-700 9.49e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 9.49e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2035341177  669 DVDECLEPNVCAN-GDCSNLEGSYMCSCHKGYT 700
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 300-330 1.24e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.24e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341177  300 DINECQLQGVCPN-GECLNTMGSYRCTCKIGF 330
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
792-832 1.33e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.33e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   792 DINECLEDkSVCQRG-DCINTAGSYDCTCPDGFQldDNKTCQ 832
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
546-576 2.90e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 2.90e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341177  546 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 576
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1293-1327 3.23e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.23e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2035341177  1293 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1327
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 546-587 5.46e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 5.46e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2035341177  546 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 587
Cdd:cd00054      1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
588-628 6.69e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 6.69e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341177   588 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 628
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1293-1327 9.02e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 9.02e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2035341177 1293 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1327
Cdd:cd00054      1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 241-276 9.13e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 38.41  E-value: 9.13e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2035341177  241 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 276
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 792-832 1.74e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.74e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2035341177  792 DINEClEDKSVCQR-GDCINTAGSYDCTCPDGFQLddnKTCQ 832
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG---RNCE 38
EGF smart00181
Epidermal growth factor-like domain;
713-743 2.00e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.11  E-value: 2.00e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2035341177   713 ECQQGNLCVNGQCKNTEGSFRCTCGQGYQLS 743
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGD 31
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 857-878 2.61e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.62  E-value: 2.61e-03
                           10        20
                   ....*....|....*....|..
gi 2035341177  857 HCVCQQGFSISADGRTCEDIDE 878
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF smart00181
Epidermal growth factor-like domain;
754-782 3.02e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.73  E-value: 3.02e-03
                            10        20
                    ....*....|....*....|....*....
gi 2035341177   754 ECQHRHLCAHGQCRNTEGSFQCVCDQGYR 782
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
EGF_CA pfam07645
Calcium-binding EGF domain;
875-905 3.10e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.10e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341177  875 DIDECVNNT-VCDSHGFCDNTAGSFRCLCYQG 905
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
303-335 3.27e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.34  E-value: 3.27e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2035341177   303 ECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPT 335
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1293-1326 3.52e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2035341177 1293 DVNECDELNNrmsLC-KNAKCINTDGSYKCLCLPG 1326
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 588-620 4.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 4.49e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2035341177  588 DVDECLRPDVCGEGH-CVNTVGAFRCEyCDSGYR 620
Cdd:cd00054      1 DIDECASGNPCQNGGtCVNTVGSYRCS-CPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 629-662 5.15e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 5.15e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2035341177  629 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 662
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 836-865 5.34e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 5.34e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2035341177  836 ECEHPGLCGPQGECLNTEGSFHCVCQQGFS 865
Cdd:cd00053      1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYT 30
EGF_CA pfam07645
Calcium-binding EGF domain;
300-329 5.81e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 5.81e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341177  300 DINEC-QLQGVCP-NGECLNTMGSYRCTCKIG 329
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
672-700 6.13e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.57  E-value: 6.13e-03
                            10        20
                    ....*....|....*....|....*....
gi 2035341177   672 ECLEPNVCANGDCSNLEGSYMCSCHKGYT 700
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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