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Conserved domains on  [gi|2035341174|ref|NP_001381845|]
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latent-transforming growth factor beta-binding protein 1 isoform 17 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 281-322 9.23e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 63.84  E-value: 9.23e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2035341174  281 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 322
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 952-994 5.25e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 55.75  E-value: 5.25e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341174  952 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 994
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1128-1170 3.09e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.82  E-value: 3.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341174 1128 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1170
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
795-836 5.69e-08

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.94  E-value: 5.69e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   795 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 836
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
713-753 1.62e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.62e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   713 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 753
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
672-703 4.64e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 4.64e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2035341174   672 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 703
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
837-878 1.18e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.18e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   837 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFqapQDGQGCV 878
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
631-670 2.10e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.10e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2035341174   631 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 670
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
219-249 4.75e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.75e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2035341174   219 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 249
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
508-549 6.71e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 6.71e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2035341174   508 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 549
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
754-784 9.10e-05

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 9.10e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341174  754 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 784
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 335-461 3.35e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 3.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035341174  335 RRRPIHHHVGKGPVfvkPKNTQPVAKsthPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPG 414
Cdd:PHA03247  2878 PARPPVRRLARPAV---SRSTESFAL---PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2035341174  415 QPQLSPGISTI---HLHP-QFPVVIEKTSPPVPVEVAPEASTSSASQVIAP 461
Cdd:PHA03247  2952 AGEPSGAVPQPwlgALVPgRVAVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
EGF_CA smart00179
Calcium-binding EGF-like domain;
1255-1289 4.22e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 4.22e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2035341174  1255 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1289
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
550-590 8.90e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 8.90e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   550 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 590
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 160-195 1.06e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 38.03  E-value: 1.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2035341174  160 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 195
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 591-624 6.60e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.60e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2035341174  591 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 624
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 281-322 9.23e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 63.84  E-value: 9.23e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2035341174  281 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 322
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 952-994 5.25e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 55.75  E-value: 5.25e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341174  952 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 994
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1128-1170 3.09e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.82  E-value: 3.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341174 1128 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1170
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
795-836 5.69e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.94  E-value: 5.69e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   795 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 836
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 795-836 3.34e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 3.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2035341174  795 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 836
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
713-753 1.62e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.62e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   713 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 753
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
672-703 4.64e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 4.64e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2035341174   672 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 703
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 713-753 5.19e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.19e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2035341174  713 DIDECQHRHLC-AHGQCRNTEGSFQCVCDQGYRasglGDHCE 753
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 672-704 1.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2035341174  672 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 704
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
837-878 1.18e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.18e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   837 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFqapQDGQGCV 878
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
631-670 2.10e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.10e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2035341174   631 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 670
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 837-869 3.52e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.52e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2035341174  837 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 869
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
219-249 4.75e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.75e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2035341174   219 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 249
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
508-549 6.71e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 6.71e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2035341174   508 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 549
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
754-784 9.10e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 9.10e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341174  754 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 784
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 631-662 1.21e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.21e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2035341174  631 DVDECLEPNVCAN-GDCSNLEGSYMCSCHKGYT 662
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 219-249 1.60e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.60e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341174  219 DINECQLQGVCPN-GECLNTMGSYRCTCKIGF 249
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
754-794 1.76e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.76e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   754 DINECLEDkSVCQRG-DCINTAGSYDCTCPDGFQldDNKTCQ 794
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGYT--DGRNCE 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 335-461 3.35e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 3.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035341174  335 RRRPIHHHVGKGPVfvkPKNTQPVAKsthPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPG 414
Cdd:PHA03247  2878 PARPPVRRLARPAV---SRSTESFAL---PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2035341174  415 QPQLSPGISTI---HLHP-QFPVVIEKTSPPVPVEVAPEASTSSASQVIAP 461
Cdd:PHA03247  2952 AGEPSGAVPQPwlgALVPgRVAVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
EGF_CA pfam07645
Calcium-binding EGF domain;
508-538 3.43e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 3.43e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341174  508 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 538
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1255-1289 4.22e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 4.22e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2035341174  1255 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1289
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 508-549 7.42e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 7.42e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2035341174  508 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 549
Cdd:cd00054      1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
550-590 8.90e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 8.90e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   550 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 590
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 160-195 1.06e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 38.03  E-value: 1.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2035341174  160 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 195
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1255-1289 1.17e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.17e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2035341174 1255 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1289
Cdd:cd00054      1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 754-788 2.25e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.25e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2035341174  754 DINEClEDKSVCQR-GDCINTAGSYDCTCPDGFQLD 788
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTGR 35
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 819-840 3.08e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.23  E-value: 3.08e-03
                           10        20
                   ....*....|....*....|..
gi 2035341174  819 HCVCQQGFSISADGRTCEDIDE 840
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA pfam07645
Calcium-binding EGF domain;
837-867 3.70e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 3.70e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341174  837 DIDECVNNT-VCDSHGFCDNTAGSFRCLCYQG 867
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1255-1288 4.21e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2035341174 1255 DVNECDELNNrmsLC-KNAKCINTDGSYKCLCLPG 1288
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 550-582 5.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 5.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2035341174  550 DVDECLRPDVCGEGH-CVNTVGAFRCEyCDSGYR 582
Cdd:cd00054      1 DIDECASGNPCQNGGtCVNTVGSYRCS-CPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 591-624 6.60e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.60e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2035341174  591 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 624
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
219-248 7.02e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 7.02e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341174  219 DINEC-QLQGVCP-NGECLNTMGSYRCTCKIG 248
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 281-322 9.23e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 63.84  E-value: 9.23e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2035341174  281 QCMHPLSVHLTKQLCCC-SVGKAWGPHCEKCPLPGTAAFKEIC 322
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 952-994 5.25e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 55.75  E-value: 5.25e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341174  952 CDNVLAPNVTKQECCCTS-GVGWGDNCEifPCPVLGTAEFTEMC 994
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1128-1170 3.09e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.82  E-value: 3.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341174 1128 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPLKDSDDYAQLC 1170
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
795-836 5.69e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.94  E-value: 5.69e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   795 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisaDGRTCE 836
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 795-836 3.34e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 3.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2035341174  795 DINECEHPGLCGPQGECLNTEGSFHCVCQQGFSisadGRTCE 836
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
713-753 1.62e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.62e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   713 DIDECQHRHLCAHG-QCRNTEGSFQCVCDQGYRAsglGDHCE 753
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
672-703 4.64e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 4.64e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2035341174   672 DIDECQQGNLCVNG-QCKNTEGSFRCTCGQGYQ 703
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 713-753 5.19e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.19e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2035341174  713 DIDECQHRHLC-AHGQCRNTEGSFQCVCDQGYRasglGDHCE 753
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 672-704 1.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2035341174  672 DIDECQQGNLCVN-GQCKNTEGSFRCTCGQGYQL 704
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
837-878 1.18e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.18e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   837 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFqapQDGQGCV 878
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
631-670 2.10e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.10e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2035341174   631 DVDECLEPNVCANG-DCSNLEGSYMCSCHKGYTrtpDHKHC 670
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 837-869 3.52e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.52e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2035341174  837 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 869
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
219-249 4.75e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.75e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2035341174   219 DINECQLQGVCPNG-ECLNTMGSYRCTCKIGF 249
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
508-549 6.71e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 6.71e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2035341174   508 DIDECTQVqHLCSQG-RCENTEGSFLCICPAGFmasEEGTNCI 549
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
754-784 9.10e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 9.10e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341174  754 DINECLEDKSVCQR-GDCINTAGSYDCTCPDG 784
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 631-662 1.21e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.21e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2035341174  631 DVDECLEPNVCAN-GDCSNLEGSYMCSCHKGYT 662
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 219-249 1.60e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.60e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341174  219 DINECQLQGVCPN-GECLNTMGSYRCTCKIGF 249
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
754-794 1.76e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.76e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   754 DINECLEDkSVCQRG-DCINTAGSYDCTCPDGFQldDNKTCQ 794
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGYT--DGRNCE 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 335-461 3.35e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 3.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035341174  335 RRRPIHHHVGKGPVfvkPKNTQPVAKsthPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPG 414
Cdd:PHA03247  2878 PARPPVRRLARPAV---SRSTESFAL---PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2035341174  415 QPQLSPGISTI---HLHP-QFPVVIEKTSPPVPVEVAPEASTSSASQVIAP 461
Cdd:PHA03247  2952 AGEPSGAVPQPwlgALVPgRVAVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
EGF_CA pfam07645
Calcium-binding EGF domain;
508-538 3.43e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 3.43e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341174  508 DIDECTQVQHLCSQ-GRCENTEGSFLCICPAG 538
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1255-1289 4.22e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 4.22e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2035341174  1255 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1289
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 508-549 7.42e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 7.42e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2035341174  508 DIDECTQvQHLCS-QGRCENTEGSFLCICPAGFmaseEGTNCI 549
Cdd:cd00054      1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
550-590 8.90e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 8.90e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2035341174   550 DVDECLRPDVCGEG-HCVNTVGAFRCEyCDSGYrmTQRGRCE 590
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY--TDGRNCE 39
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 160-195 1.06e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 38.03  E-value: 1.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2035341174  160 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKPS 195
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1255-1289 1.17e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.17e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2035341174 1255 DVNECDELNNrmslCKN-AKCINTDGSYKCLCLPGY 1289
Cdd:cd00054      1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 754-788 2.25e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.25e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2035341174  754 DINEClEDKSVCQR-GDCINTAGSYDCTCPDGFQLD 788
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTGR 35
EGF smart00181
Epidermal growth factor-like domain;
675-705 2.43e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.73  E-value: 2.43e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2035341174   675 ECQQGNLCVNGQCKNTEGSFRCTCGQGYQLS 705
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGD 31
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 819-840 3.08e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.23  E-value: 3.08e-03
                           10        20
                   ....*....|....*....|..
gi 2035341174  819 HCVCQQGFSISADGRTCEDIDE 840
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF smart00181
Epidermal growth factor-like domain;
716-744 3.64e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.34  E-value: 3.64e-03
                            10        20
                    ....*....|....*....|....*....
gi 2035341174   716 ECQHRHLCAHGQCRNTEGSFQCVCDQGYR 744
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
EGF_CA pfam07645
Calcium-binding EGF domain;
837-867 3.70e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 3.70e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341174  837 DIDECVNNT-VCDSHGFCDNTAGSFRCLCYQG 867
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
222-254 3.98e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.34  E-value: 3.98e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2035341174   222 ECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPT 254
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1255-1288 4.21e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.21e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2035341174 1255 DVNECDELNNrmsLC-KNAKCINTDGSYKCLCLPG 1288
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 502-545 5.10e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.06  E-value: 5.10e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2035341174  502 QQRKCVDIDECTQVQHLCSQGrCENTEGSFLCICPAGFMASEEG 545
Cdd:cd01475    180 QGKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 550-582 5.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 5.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2035341174  550 DVDECLRPDVCGEGH-CVNTVGAFRCEyCDSGYR 582
Cdd:cd00054      1 DIDECASGNPCQNGGtCVNTVGSYRCS-CPPGYT 33
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 798-827 6.45e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.53  E-value: 6.45e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2035341174  798 ECEHPGLCGPQGECLNTEGSFHCVCQQGFS 827
Cdd:cd00053      1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYT 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 591-624 6.60e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.60e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2035341174  591 DIDECLNPSTC-PDEQCVNSPGSYQCVpCTEGFRG 624
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
219-248 7.02e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 7.02e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2035341174  219 DINEC-QLQGVCP-NGECLNTMGSYRCTCKIG 248
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
634-662 7.33e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.57  E-value: 7.33e-03
                            10        20
                    ....*....|....*....|....*....
gi 2035341174   634 ECLEPNVCANGDCSNLEGSYMCSCHKGYT 662
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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