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Conserved domains on  [gi|2036579292|ref|NP_001381885|]
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speedy protein E4 [Homo sapiens]

Protein Classification

Spy1 domain-containing protein( domain architecture ID 10568376)

Spy1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spy1 pfam11357
Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which ...
 104-233 1.79e-87

Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.


:

Pssm-ID: 463263  Cd Length: 131  Bit Score: 254.86  E-value: 1.79e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2036579292 104 EHHEAFNRLLGDPVVQKFLAWDKDLRVSDKYLLAMVIAYFSRAGLFSWQYQRIHFFLALYLASDMEEDNQAPKQDIFSFL 183
Cdd:pfam11357   1 EEMEAFFRLLEDPVIQDFLAWDKCLRVSDKYLLAMVFAYFKRAGLFSWEYTRINFFLALYLANDMEEDEEEPKYEIFPWA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2036579292 184 YGKNY-SQRPLFHKLRYQLLCSMRWRTWVSPEEMEEIQAYDPEHWVWARDR 233
Cdd:pfam11357  81 LGENWrDQYPLFLKLRDQLWARMGYRAAVSRECCEEIMAIDPEHWVWQRDR 131
 
Name Accession Description Interval E-value
Spy1 pfam11357
Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which ...
 104-233 1.79e-87

Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.


Pssm-ID: 463263  Cd Length: 131  Bit Score: 254.86  E-value: 1.79e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2036579292 104 EHHEAFNRLLGDPVVQKFLAWDKDLRVSDKYLLAMVIAYFSRAGLFSWQYQRIHFFLALYLASDMEEDNQAPKQDIFSFL 183
Cdd:pfam11357   1 EEMEAFFRLLEDPVIQDFLAWDKCLRVSDKYLLAMVFAYFKRAGLFSWEYTRINFFLALYLANDMEEDEEEPKYEIFPWA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2036579292 184 YGKNY-SQRPLFHKLRYQLLCSMRWRTWVSPEEMEEIQAYDPEHWVWARDR 233
Cdd:pfam11357  81 LGENWrDQYPLFLKLRDQLWARMGYRAAVSRECCEEIMAIDPEHWVWQRDR 131
 
Name Accession Description Interval E-value
Spy1 pfam11357
Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which ...
 104-233 1.79e-87

Cell cycle regulatory protein; Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.


Pssm-ID: 463263  Cd Length: 131  Bit Score: 254.86  E-value: 1.79e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2036579292 104 EHHEAFNRLLGDPVVQKFLAWDKDLRVSDKYLLAMVIAYFSRAGLFSWQYQRIHFFLALYLASDMEEDNQAPKQDIFSFL 183
Cdd:pfam11357   1 EEMEAFFRLLEDPVIQDFLAWDKCLRVSDKYLLAMVFAYFKRAGLFSWEYTRINFFLALYLANDMEEDEEEPKYEIFPWA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2036579292 184 YGKNY-SQRPLFHKLRYQLLCSMRWRTWVSPEEMEEIQAYDPEHWVWARDR 233
Cdd:pfam11357  81 LGENWrDQYPLFLKLRDQLWARMGYRAAVSRECCEEIMAIDPEHWVWQRDR 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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