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Conserved domains on  [gi|2072749947|ref|NP_001382563|]
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testis-expressed protein 30 [Rattus norvegicus]

Protein Classification

COG3571 superfamily protein( domain architecture ID 1903980)

COG3571 superfamily protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3571 super family cl43903
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
31-220 7.02e-33

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


The actual alignment was detected with superfamily member COG3571:

Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 117.67  E-value: 7.02e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  31 GIILTHGASGDMNLPHLMSLASHLASHGFFCLRFtckglNIVHRIK-------------AYKAVLNYLKTsgeyKLAG-- 95
Cdd:COG3571    11 TLLLAHGAGAGMDSPFMVALAEALAAAGIAVARF-----EFPYMVAgrrppdrapvldaAWRAVIAALRA----RLAGlp 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  96 VFLGGRSMGSRAAasvmCHTEldDADDFVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEKVA 175
Cdd:COG3571    82 LVIGGKSMGGRVA----SMLA--AEGGGAAGLVCLGYPFHPPGKPEKLRTEHLADLTVPTLIVQGERDPFGTPEEVAGYP 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2072749947 176 qkMQAPSKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQEIT 220
Cdd:COG3571   156 --LPPAIELVWLPGGDHDLKPRkrsGRTQEDHLAAAADAVAAWLARLL 201
 
Name Accession Description Interval E-value
COG3571 COG3571
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
31-220 7.02e-33

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 117.67  E-value: 7.02e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  31 GIILTHGASGDMNLPHLMSLASHLASHGFFCLRFtckglNIVHRIK-------------AYKAVLNYLKTsgeyKLAG-- 95
Cdd:COG3571    11 TLLLAHGAGAGMDSPFMVALAEALAAAGIAVARF-----EFPYMVAgrrppdrapvldaAWRAVIAALRA----RLAGlp 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  96 VFLGGRSMGSRAAasvmCHTEldDADDFVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEKVA 175
Cdd:COG3571    82 LVIGGKSMGGRVA----SMLA--AEGGGAAGLVCLGYPFHPPGKPEKLRTEHLADLTVPTLIVQGERDPFGTPEEVAGYP 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2072749947 176 qkMQAPSKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQEIT 220
Cdd:COG3571   156 --LPPAIELVWLPGGDHDLKPRkrsGRTQEDHLAAAADAVAAWLARLL 201
Abhydrolase_11 pfam20408
Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta ...
 32-217 2.14e-26

Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta hydrolase superfamily. Although proteins in this family are uncharacterized they are likely to have an enzymatic activity.


Pssm-ID: 466557 [Multi-domain]  Cd Length: 193  Bit Score: 100.74  E-value: 2.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  32 IILTHGASGDMNLPHLMSLASHLASHGFFCLRFT--------CKG-------LNIVhrIKAYKAVLNYLKTSGeyklAGV 96
Cdd:pfam20408   5 LLLAHGAGAGMDSPFMQAMAAALAARGIAVVRFNfpymqrrrRTGkrrppdrAPKL--LEAFRAVIAALRGPD----LPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  97 FLGGRSMGSRAAASVmchteLDDADdfVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEkvAQ 176
Cdd:pfam20408  79 FIGGKSMGGRVASLL-----ADDSG--VKGVIALGYPFHPPGKPEKLRLEHLPDLTCPTLILQGERDPFGNREEVA--AY 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2072749947 177 KMQAPSKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQ 217
Cdd:pfam20408 150 PLPDNVSLHWLEDGDHDFKPRkrsGLTHEQNLQEAADAIAAFIA 193
 
Name Accession Description Interval E-value
COG3571 COG3571
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
31-220 7.02e-33

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 442792 [Multi-domain]  Cd Length: 202  Bit Score: 117.67  E-value: 7.02e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  31 GIILTHGASGDMNLPHLMSLASHLASHGFFCLRFtckglNIVHRIK-------------AYKAVLNYLKTsgeyKLAG-- 95
Cdd:COG3571    11 TLLLAHGAGAGMDSPFMVALAEALAAAGIAVARF-----EFPYMVAgrrppdrapvldaAWRAVIAALRA----RLAGlp 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  96 VFLGGRSMGSRAAasvmCHTEldDADDFVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEKVA 175
Cdd:COG3571    82 LVIGGKSMGGRVA----SMLA--AEGGGAAGLVCLGYPFHPPGKPEKLRTEHLADLTVPTLIVQGERDPFGTPEEVAGYP 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2072749947 176 qkMQAPSKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQEIT 220
Cdd:COG3571   156 --LPPAIELVWLPGGDHDLKPRkrsGRTQEDHLAAAADAVAAWLARLL 201
Abhydrolase_11 pfam20408
Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta ...
 32-217 2.14e-26

Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta hydrolase superfamily. Although proteins in this family are uncharacterized they are likely to have an enzymatic activity.


Pssm-ID: 466557 [Multi-domain]  Cd Length: 193  Bit Score: 100.74  E-value: 2.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  32 IILTHGASGDMNLPHLMSLASHLASHGFFCLRFT--------CKG-------LNIVhrIKAYKAVLNYLKTSGeyklAGV 96
Cdd:pfam20408   5 LLLAHGAGAGMDSPFMQAMAAALAARGIAVVRFNfpymqrrrRTGkrrppdrAPKL--LEAFRAVIAALRGPD----LPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  97 FLGGRSMGSRAAASVmchteLDDADdfVRGLICISYPLHHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEkvAQ 176
Cdd:pfam20408  79 FIGGKSMGGRVASLL-----ADDSG--VKGVIALGYPFHPPGKPEKLRLEHLPDLTCPTLILQGERDPFGNREEVA--AY 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2072749947 177 KMQAPSKIHWIEKANHSMAVK---GRSTNDVFKEINTQILFWIQ 217
Cdd:pfam20408 150 PLPDNVSLHWLEDGDHDFKPRkrsGLTHEQNLQEAADAIAAFIA 193
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
1-194 8.39e-12

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 62.33  E-value: 8.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947   1 MSHTEVKLKIPFGNKLlDAVCLVPNKNIAYGIILTHGASGDMNlpHLMSLASHLASHGFFCLRF-------TCKGLNIVH 73
Cdd:COG2267     1 MTRRLVTLPTRDGLRL-RGRRWRPAGSPRGTVVLVHGLGEHSG--RYAELAEALAAAGYAVLAFdlrghgrSDGPRGHVD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  74 RIKAY----KAVLNYLKTSGEYKlagVFLGGRSMGSRAAASVmchteLDDADDFVRGLICIS-----YPLHHPKQQHkLR 144
Cdd:COG2267    78 SFDDYvddlRAALDALRARPGLP---VVLLGHSMGGLIALLY-----AARYPDRVAGLVLLApayraDPLLGPSARW-LR 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2072749947 145 D----EDLFRIKDPVLFVSGSADEMCEKNLLEKVAQKMQAPSKIHWIEKANHSM 194
Cdd:COG2267   149 AlrlaEALARIDVPVLVLHGGADRVVPPEAARRLAARLSPDVELVLLPGARHEL 202
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
32-208 1.21e-08

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 53.48  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  32 IILTHGASGDMNlPHLMSLASHLASHGFFCLRF------TCKGLNIVHRIKAYKAVLNYLKTSGEYKLAGVFLGGRSMGS 105
Cdd:COG1506    26 VVYVHGGPGSRD-DSFLPLAQALASRGYAVLAPdyrgygESAGDWGGDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947 106 RAAASVMCHTelddaDDFVRGLICIS------------YPLHHPKQQHKLRDEDLF----------RIKDPVLFVSGSAD 163
Cdd:COG1506   105 YMALLAAARH-----PDRFKAAVALAgvsdlrsyygttREYTERLMGGPWEDPEAYaarsplayadKLKTPLLLIHGEAD 179

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2072749947 164 EMCEKNLLEKVAQKMQA---PSKIHWIEKANHSMAvkGRSTNDVFKEI 208
Cdd:COG1506   180 DRVPPEQAERLYEALKKagkPVELLVYPGEGHGFS--GAGAPDYLERI 225
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
17-192 1.32e-08

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 52.86  E-value: 1.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  17 LDAVCLVPNKNIAYGIILTH---GASGDMNLPHLMSLASHLASHGFFCLRF----TCK--GlnivhrikAY--------- 78
Cdd:COG2945    11 LEGRLDLPEGPPRGVALILHphpLFGGTMDNKVVYTLARALVAAGFAVLRFnfrgVGRseG--------EFdegrgeldd 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  79 -KAVLNYLKTSGeykLAGVFLGGRSMGSRAAASVMChtelddADDFVRGLICISYPLHHpkqqhkLRDEDLFRIKDPVLF 157
Cdd:COG2945    83 aAAALDWLRAQN---PLPLWLAGFSFGAYVALQLAM------RLPEVEGLILVAPPVNR------YDFSFLAPCPAPTLV 147

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2072749947 158 VSGSADEMCEKNLLEKVAQKMQAPSKIHWIEKANH 192
Cdd:COG2945   148 IHGEQDEVVPPAEVLDWARPLSPPLPVVVVPGADH 182
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
31-203 2.76e-08

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 52.28  E-value: 2.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  31 GIILTHGASGdMNlPHLMSLASHLASHGFFCL---RFTCKG--------------LNIVHRIKAYKAVLNYLKTSGEYKL 93
Cdd:COG0412    31 GVVVLHEIFG-LN-PHIRDVARRLAAAGYVVLapdLYGRGGpgddpdearalmgaLDPELLAADLRAALDWLKAQPEVDA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  94 AGVFLGGRSMGSRAAASVMCHTELDDAddfvrgliCISYplhHPKQQHKLRDEDLFRIKDPVLFVSGSADEMCEKNLLEK 173
Cdd:COG0412   109 GRVGVVGFCFGGGLALLAAARGPDLAA--------AVSF---YGGLPADDLLDLAARIKAPVLLLYGEKDPLVPPEQVAA 177

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2072749947 174 VAQKMQA---PSKIHWIEKANHSMAVKGRSTND 203
Cdd:COG0412   178 LEAALAAagvDVELHVYPGAGHGFTNPGRPRYD 210
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
30-221 3.33e-06

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 46.47  E-value: 3.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  30 YGIILTHGASGDMNlpHLMSLASHLASHGFFCLRFTCKG--------LNIVHR--IKAYKAVLNYLKTSGEYklagVFLG 99
Cdd:COG1647    16 KGVLLLHGFTGSPA--EMRPLAEALAKAGYTVYAPRLPGhgtspedlLKTTWEdwLEDVEEAYEILKAGYDK----VIVI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947 100 GRSMGS----RAAASvmchtelddaDDFVRGLICIS------------------------------------------YP 133
Cdd:COG1647    90 GLSMGGllalLLAAR----------YPDVAGLVLLSpalkiddpsapllpllkylarslrgigsdiedpevaeyaydrTP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947 134 LHHPKQQHKLRDE---DLFRIKDPVLFVSGSADEMCEKNLLEKVAQKMQAPSK-IHWIEKANHSMAVkGRSTNDVFKEIN 209
Cdd:COG1647   160 LRALAELQRLIREvrrDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKeLVWLEDSGHVITL-DKDREEVAEEIL 238

                         250
                  ....*....|..
gi 2072749947 210 TqilfWIQEITE 221
Cdd:COG1647   239 D----FLERLAA 246
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
32-215 2.21e-05

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 44.33  E-value: 2.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  32 IILTHGASGDMNLphLMSLASHLASHGFFC-------------------LRFTCKGLNIVHRIKAYKAVLNYLKTSGEYK 92
Cdd:COG4188    65 VVLSHGLGGSREG--YAYLAEHLASHGYVVaapdhpgsnaadlsaaldgLADALDPEELWERPLDLSFVLDQLLALNKSD 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  93 --LAG------VFLGGRSMGSRAAASVMCHT----ELDDADDFVRGLICISYPLHHPKQQhkLRD--------------- 145
Cdd:COG4188   143 ppLAGrldldrIGVIGHSLGGYTALALAGARldfaALRQYCGKNPDLQCRALDLPRLAYD--LRDprikavvalapggsg 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947 146 ----EDLFRIKDPVLFVSGSADEMcEKNLLE--KVAQKMQAPSK-IHWIEKANHSM---------------AVKGRSTND 203
Cdd:COG4188   221 lfgeEGLAAITIPVLLVAGSADDV-TPAPDEqiRPFDLLPGADKyLLTLEGATHFSfldpctpgaailpepDPPGPDRAA 299

                         250
                  ....*....|...
gi 2072749947 204 VFKEINTQIL-FW 215
Cdd:COG4188   300 IHEYLNALSLaFF 312
DLH pfam01738
Dienelactone hydrolase family;
79-200 4.31e-04

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 40.03  E-value: 4.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2072749947  79 KAVLNYLKTSGEYKLAGVFLGGRSMGSRAAASVMCHTELDDAddfvrgliCISYPLHHPKQQHKLRDedlfRIKDPVLFV 158
Cdd:pfam01738  81 EAAVNYLKSQPEVSPKKVGVVGYCMGGALAVLLAAKGPLVDA--------AVGFYGVGPEPPLIEAP----DIKAPILFH 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2072749947 159 SGSADEMCEKNLLEKVAQKM---QAPSKIHWIEKANHSMAVKGRS 200
Cdd:pfam01738 149 FGEEDHFVPADSRELIEEALkaaNVDHQIHSYPGAGHAFANDSRP 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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