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Conserved domains on  [gi|4557543|ref|NP_001384|]
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extracellular matrix protein 2 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
316-673 1.25e-25

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 1.25e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  316 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitssgigpkAFKLLKKL 395
Cdd:COG4886  45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  396 MRLNMDGNNLIQIPSQLPS--TLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGK 473
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  474 NKFRIIPQGLPG--SIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 551
Cdd:COG4886 192 NQITDLPEPLGNltNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  552 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE 629
Cdd:COG4886 245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 4557543  630 MKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIK 673
Cdd:COG4886 321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 7.24e-15

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 69.38  E-value: 7.24e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4557543    103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
Amnionless super family cl28792
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 116-211 1.09e-04

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


The actual alignment was detected with superfamily member pfam14828:

Pssm-ID: 464340  Cd Length: 449  Bit Score: 45.07  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543    116 WSPEPC---TTCLCSDGRVLcdETMCH--PQRCPQT-----VIPEGECCPVCSATVSysllsgiaLNDRNEFSGDSSEQR 185
Cdd:pfam14828 186 VGPEACsdpSGCGCGNDENL--ERICAnvLQRCPPPhclspLRPEGHCCDVCGAIVS--------LDYSSCFDLQTYRAR 255

                          90       100       110
                  ....*....|....*....|....*....|.
gi 4557543    186 eptnLLHKQLPPP-----QVGMDRIVRKEAL 211
Cdd:pfam14828 256 ----LRHLFLALPkykgvQLAVSKVGKDQRL 282
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
316-673 1.25e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 1.25e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  316 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitssgigpkAFKLLKKL 395
Cdd:COG4886  45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  396 MRLNMDGNNLIQIPSQLPS--TLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGK 473
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  474 NKFRIIPQGLPG--SIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 551
Cdd:COG4886 192 NQITDLPEPLGNltNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  552 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE 629
Cdd:COG4886 245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 4557543  630 MKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIK 673
Cdd:COG4886 321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
320-572 1.16e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.36  E-value: 1.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   320 CSLSYRTISCINAM-LTQIPPLTAPQITSLELTGNSIASIPDeafNGLPNLERLDLSKNNITSSgigPKAfkLLKKLMRL 398
Cdd:PRK15370 175 CLKNNKTELRLKILgLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLTSI---PAT--LPDTIQEM 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   399 NMDGNNLIQIPSQLPSTLEELKVNENNLQAIdEESLSDlnQLVTLELEGNNLS-----------EANV--NPLAFKPLK- 464
Cdd:PRK15370 247 ELSINRITELPERLPSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRtlpahlpsgitHLNVqsNSLTALPETl 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   465 --SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEIcfnhtrkinvivlrynkieenrIAPlawinqeNLESIDL 542
Cdd:PRK15370 324 ppGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPET----------------------LPP-------TITTLDV 374

                        250       260       270
                 ....*....|....*....|....*....|
gi 4557543   543 SYNKLYHVPSYLPKSLLHLVLLGNQIERIP 572
Cdd:PRK15370 375 SRNALTNLPENLPAALQIMQASRNNLVRLP 404
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 7.24e-15

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 69.38  E-value: 7.24e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4557543    103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
LRR_8 pfam13855
Leucine rich repeat;
343-405 1.05e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 1.05e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4557543    343 PQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSsgIGPKAFKLLKKLMRLNMDGNNL 405
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
VWC smart00214
von Willebrand factor (vWF) type C domain;
103-157 2.08e-12

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 62.53  E-value: 2.08e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 4557543     103 CLVKGITMYNKAVWSPEPCTTCLCSDGR-VLCDETMCHP-QRCPQ--TVIPEGECCPVC 157
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNpeRVKPPGECCPRC 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 334-504 3.59e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.49  E-value: 3.59e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  334 LTQIPPL-TAPQITSLELTGNSIASIpdEAFNGLPNLERLDLSKNNITSsgigpkafklLKKLMRLNMdgnnliqipsql 412
Cdd:cd21340  36 ITKIENLeFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISV----------VEGLENLTN------------ 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  413 pstLEELKVNENNLQ-----AIDEESLSDL-NQLVTLELEGNNLSEanvnplafkpLKSLAYLRlgknkfriipqglpgS 486
Cdd:cd21340  92 ---LEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNIDS----------LEPLAPLR---------------N 143

                       170
                ....*....|....*...
gi 4557543  487 IEELYLENNQIEEITEIC 504
Cdd:cd21340 144 LEQLDASNNQISDLEELL 161
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 116-211 1.09e-04

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 45.07  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543    116 WSPEPC---TTCLCSDGRVLcdETMCH--PQRCPQT-----VIPEGECCPVCSATVSysllsgiaLNDRNEFSGDSSEQR 185
Cdd:pfam14828 186 VGPEACsdpSGCGCGNDENL--ERICAnvLQRCPPPhclspLRPEGHCCDVCGAIVS--------LDYSSCFDLQTYRAR 255

                          90       100       110
                  ....*....|....*....|....*....|.
gi 4557543    186 eptnLLHKQLPPP-----QVGMDRIVRKEAL 211
Cdd:pfam14828 256 ----LRHLFLALPkykgvQLAVSKVGKDQRL 282
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
316-673 1.25e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 1.25e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  316 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitssgigpkAFKLLKKL 395
Cdd:COG4886  45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  396 MRLNMDGNNLIQIPSQLPS--TLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGK 473
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  474 NKFRIIPQGLPG--SIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 551
Cdd:COG4886 192 NQITDLPEPLGNltNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  552 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE 629
Cdd:COG4886 245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 4557543  630 MKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIK 673
Cdd:COG4886 321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
337-674 1.02e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.25  E-value: 1.02e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  337 IPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTL 416
Cdd:COG4886  13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  417 EELKvNENNLQAIDEESLSDLNQLVTLELEGNNLSEAnvnPLAFKPLKSLAYLRLGKNKFRIIPQGLPG--SIEELYLEN 494
Cdd:COG4886  93 GDLT-NLTELDLSGNEELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSN 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  495 NQIEEITEICFNHTrKINVIVLRYNKIEEnriAPLAWINQENLESIDLSYNKLYHVPSYLP--KSLLHLVLLGNQIERIP 572
Cdd:COG4886 169 NQLTDLPEELGNLT-NLKELDLSNNQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  573 GyvFGHMePGLEYLYLSFNKLADdgmdrVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEIC 652
Cdd:COG4886 245 E--LGNL-TNLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                       330       340
                ....*....|....*....|..
gi 4557543  653 NAEEDDDSNLEHLHLENNYIKI 674
Cdd:COG4886 317 LLLLTTLLLLLLLLKGLLVTLT 338
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
325-624 8.44e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 8.44e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  325 RTISCINAMLTQIPPLTA--PQITSLELTGNSIASIPDEaFNGLPNLERLDLSKNNITSsgIgPKAFKLLKKLMRLNMDG 402
Cdd:COG4886 116 ESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTD--L-PEELGNLTNLKELDLSN 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  403 NNLIQIPSQL--PSTLEELKVNENNLQAIDEEsLSDLNQLVTLELEGNNLSEANvnplAFKPLKSLAYLRLGKNKFRIIP 480
Cdd:COG4886 192 NQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLP 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  481 QGLP-GSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLL 559
Cdd:COG4886 267 PLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4557543  560 HLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIP 624
Cdd:COG4886 347 LALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
372-679 2.31e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 2.31e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  372 LDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLS 451
Cdd:COG4886   4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  452 EANVNPLAFKPLKSLAYLRLGKNKfriiPQGLPGSIEELYLENNQIEEITEicfnhtrkinvivlrynkieenRIAPLaw 531
Cdd:COG4886  84 LLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPE----------------------ELANL-- 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  532 inqENLESIDLSYNKLYHVPSYLP--KSLLHLVLLGNQIERIPGyVFGHMePGLEYLYLSFNKLADDGMdrvSFYGAyHS 609
Cdd:COG4886 136 ---TNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNL-TNLKELDLSNNQITDLPE---PLGNL-TN 206

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  610 LRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNIlpEEICNAeedddSNLEHLHLENNyiKIREIPS 679
Cdd:COG4886 207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL--PELGNL-----TNLEELDLSNN--QLTDLPP 267
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
320-572 1.16e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.36  E-value: 1.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   320 CSLSYRTISCINAM-LTQIPPLTAPQITSLELTGNSIASIPDeafNGLPNLERLDLSKNNITSSgigPKAfkLLKKLMRL 398
Cdd:PRK15370 175 CLKNNKTELRLKILgLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLTSI---PAT--LPDTIQEM 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   399 NMDGNNLIQIPSQLPSTLEELKVNENNLQAIdEESLSDlnQLVTLELEGNNLS-----------EANV--NPLAFKPLK- 464
Cdd:PRK15370 247 ELSINRITELPERLPSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRtlpahlpsgitHLNVqsNSLTALPETl 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   465 --SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEIcfnhtrkinvivlrynkieenrIAPlawinqeNLESIDL 542
Cdd:PRK15370 324 ppGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPET----------------------LPP-------TITTLDV 374

                        250       260       270
                 ....*....|....*....|....*....|
gi 4557543   543 SYNKLYHVPSYLPKSLLHLVLLGNQIERIP 572
Cdd:PRK15370 375 SRNALTNLPENLPAALQIMQASRNNLVRLP 404
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 7.24e-15

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 69.38  E-value: 7.24e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4557543    103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
314-571 8.63e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.20  E-value: 8.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   314 LRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEafngLPN-LERLDLSKNNITSSgigPKafKLL 392
Cdd:PRK15370 212 KSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPER----LPSaLQSLDLFHNKISCL---PE--NLP 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   393 KKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNqlvTLELEGNNLSEAnvnPLAFKPlkSLAYLRLG 472
Cdd:PRK15370 283 EELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLK---TLEAGENALTSL---PASLPP--ELQVLDVS 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   473 KNKFRIIPQGLPGSIEELYLENNQIEEITEicfnhtrkiNVivlrynkieenriaPLAwinqenLESIDLSYNKLyhvpS 552
Cdd:PRK15370 355 KNQITVLPETLPPTITTLDVSRNALTNLPE---------NL--------------PAA------LQIMQASRNNL----V 401

                        250
                 ....*....|....*....
gi 4557543   553 YLPKSLLHLVLLGNQIERI 571
Cdd:PRK15370 402 RLPESLPHFRGEGPQPTRI 420
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
393-633 2.43e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 76.66  E-value: 2.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   393 KKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIdEESLSDLNQLvtLELEGNNLSEANVN-PLAFKPL-------- 463
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSI-PATLPDTIQE--MELSINRITELPERlPSALQSLdlfhnkis 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   464 -------KSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEicfnhTRKINVIVLrynKIEENRIAPLAWINQEN 536
Cdd:PRK15370 276 clpenlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE-----TLPPGLKTL---EAGENALTSLPASLPPE 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   537 LESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPgyvfGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLD 616
Cdd:PRK15370 348 LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLP----ENLPAALQIMQASRNNLVRLPESLPHFRGEGPQPTRIIVE 423

                        250
                 ....*....|....*..
gi 4557543   617 HNDLKSipPGIQEMKAL 633
Cdd:PRK15370 424 YNPFSE--RTIQNMQRL 438
LRR_8 pfam13855
Leucine rich repeat;
343-405 1.05e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 1.05e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4557543    343 PQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSsgIGPKAFKLLKKLMRLNMDGNNL 405
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
VWC smart00214
von Willebrand factor (vWF) type C domain;
103-157 2.08e-12

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 62.53  E-value: 2.08e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 4557543     103 CLVKGITMYNKAVWSPEPCTTCLCSDGR-VLCDETMCHP-QRCPQ--TVIPEGECCPVC 157
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNpeRVKPPGECCPRC 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
391-651 9.76e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.10  E-value: 9.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   391 LLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEeslsdlnqlvtlELEGNnlseanvnplafkpLKSLaYLR 470
Cdd:PRK15370 176 LKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPE------------NLQGN--------------IKTL-YAN 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   471 lgKNKFRIIPQGLPGSIEELYLENNQIEEITEicfNHTRKINVIVLRYNKieenrIAPLAWINQENLESIDLSYNKLYHV 550
Cdd:PRK15370 229 --SNQLTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNK-----ISCLPENLPEELRYLSVYDNSIRTL 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   551 PSYLPKSLLHLVLLGNQIERIPGYvfghMEPGLEYLYLSFNKLA-------------DDGMDRVSFYGAY--HSLRELFL 615
Cdd:PRK15370 299 PAHLPSGITHLNVQSNSLTALPET----LPPGLKTLEAGENALTslpaslppelqvlDVSKNQITVLPETlpPTITTLDV 374

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 4557543   616 DHNDLKSIPPGIQemKALHFLRLNNNKIRNiLPEEI 651
Cdd:PRK15370 375 SRNALTNLPENLP--AALQIMQASRNNLVR-LPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 331-667 1.57e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.48  E-value: 1.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   331 NAMLTQIPP--LTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITssGIGPKAFKLLKKLMRLNMDGNNLI-Q 407
Cdd:PLN00113 270 NKLSGPIPPsiFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT--GKIPVALTSLPRLQVLQLWSNKFSgE 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   408 IPSQL--PSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLsEANVnPLAFKPLKSLAYLRLGKNKFRiipQGLPG 485
Cdd:PLN00113 348 IPKNLgkHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSL-EGEI-PKSLGACRSLRRVRLQDNSFS---GELPS 422

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   486 SIEELYLennqieeiteicfnhtrkINVIVLRYNKIEeNRIAPLAWiNQENLESIDLSYNKLY-HVP-SYLPKSLLHLVL 563
Cdd:PLN00113 423 EFTKLPL------------------VYFLDISNNNLQ-GRINSRKW-DMPSLQMLSLARNKFFgGLPdSFGSKRLENLDL 482

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   564 LGNQIERIPGYVFGHMePGLEYLYLSFNKLADDGMDRVSfygAYHSLRELFLDHNDLK-SIPPGIQEMKALHFLRLNNNK 642
Cdd:PLN00113 483 SRNQFSGAVPRKLGSL-SELMQLKLSENKLSGEIPDELS---SCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQ 558

                        330       340
                 ....*....|....*....|....*
gi 4557543   643 IRNILPEEICNAEEDDDSNLEHLHL 667
Cdd:PLN00113 559 LSGEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 344-670 2.29e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 2.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   344 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNItSSGIGPKAFKLLKKLMRLNMDGNNLI-QIPSQLPSTLEELKVN 422
Cdd:PLN00113  70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLS 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   423 ENNLQAIDEESLSDLNQLVTLELEGNNLSeaNVNPLAFKPLKSLAYLRLGKNKFriiPQGLPGSIEELylennqieeite 502
Cdd:PLN00113 149 NNMLSGEIPNDIGSFSSLKVLDLGGNVLV--GKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQM------------ 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   503 icfnhtRKINVIVLRYNKIE---ENRIAPLAWINQenlesIDLSYNKLyhvPSYLPKSLLHLvllgnqieripgyvfghm 579
Cdd:PLN00113 212 ------KSLKWIYLGYNNLSgeiPYEIGGLTSLNH-----LDLVYNNL---TGPIPSSLGNL------------------ 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   580 ePGLEYLYLSFNKLADdgmdrvsfygayhslrelfldhndlkSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEeddd 659
Cdd:PLN00113 260 -KNLQYLFLYQNKLSG--------------------------PIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQ---- 308

                        330
                 ....*....|.
gi 4557543   660 sNLEHLHLENN 670
Cdd:PLN00113 309 -NLEILHLFSN 318
LRR_8 pfam13855
Leucine rich repeat;
367-450 2.69e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 2.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543    367 PNLERLDLSKNNITSsgIGPKAFKLLKKLMRLNMdgnnliqipsqlpstleelkvNENNLQAIDEESLSDLNQLVTLELE 446
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDL---------------------SNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 4557543    447 GNNL 450
Cdd:pfam13855  58 GNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
312-572 2.85e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 60.56  E-value: 2.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   312 GTLRLPSGCSLSYRTISCINAMLTQIPPLtAPQITSLELTGNSIASIPDEAfnglPNLERLDLSKNNITSSGIGPKAfkl 391
Cdd:PRK15387 212 GLTTLPDCLPAHITTLVIPDNNLTSLPAL-PPELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHLPALPSG--- 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   392 lkkLMRLNMDGNNLIQIPSqLPSTLEELKVNENNLQaideeSLSDL-NQLVTLELEGNNLSEANVNPlafkplKSLAYLR 470
Cdd:PRK15387 284 ---LCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLA-----SLPALpSELCKLWAYNNQLTSLPTLP------SGLQELS 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   471 LGKNKFRIIPQgLPGSIEELYLENNQIEEITEICFNHTRKInvivlrynkIEENRIAPLAWINQEnLESIDLSYNKLYHV 550
Cdd:PRK15387 349 VSDNQLASLPT-LPSELYKLWAYNNRLTSLPALPSGLKELI---------VSGNRLTSLPVLPSE-LKELMVSGNRLTSL 417

                        250       260
                 ....*....|....*....|..
gi 4557543   551 PsYLPKSLLHLVLLGNQIERIP 572
Cdd:PRK15387 418 P-MLPSGLLSLSVYRNQLTRLP 438
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 334-504 3.59e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.49  E-value: 3.59e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  334 LTQIPPL-TAPQITSLELTGNSIASIpdEAFNGLPNLERLDLSKNNITSsgigpkafklLKKLMRLNMdgnnliqipsql 412
Cdd:cd21340  36 ITKIENLeFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISV----------VEGLENLTN------------ 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  413 pstLEELKVNENNLQ-----AIDEESLSDL-NQLVTLELEGNNLSEanvnplafkpLKSLAYLRlgknkfriipqglpgS 486
Cdd:cd21340  92 ---LEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNIDS----------LEPLAPLR---------------N 143

                       170
                ....*....|....*...
gi 4557543  487 IEELYLENNQIEEITEIC 504
Cdd:cd21340 144 LEQLDASNNQISDLEELL 161
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 343-547 8.48e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.26  E-value: 8.48e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  343 PQITSLELTGNSI----ASIPDEAFNGLPNLERLDLSKNNITSSGIGP--KAFKLLKKLMRLNMDGNNL-----IQIPSQ 411
Cdd:COG5238 208 TTVTTLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIGDEGVIAlaEALKNNTTVETLYLSGNQIgaegaIALAKA 287

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  412 L--PSTLEELKVNENNLQaiDE------ESLSDLNQLVTLELEGNNLSEANVNPL--AFKPLKSLAYLRLGKNKfrIIPQ 481
Cdd:COG5238 288 LqgNTTLTSLDLSVNRIG--DEgaialaEGLQGNKTLHTLNLAYNGIGAQGAIALakALQENTTLHSLDLSDNQ--IGDE 363

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4557543  482 GLPGSIEelYLENNQieeiteicfnHTRKINvivLRYNKI-EENRIAPLAWINQENLESIDLSYNKL 547
Cdd:COG5238 364 GAIALAK--YLEGNT----------TLRELN---LGKNNIgKQGAEALIDALQTNRLHTLILDGNLI 415
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
398-679 4.94e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 56.32  E-value: 4.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   398 LNMDGNNLIQIPSQLPSTLEELKVNENNLQaideeSLSDL-NQLVTLELEGNNLSEANV------------NPLAFKPL- 463
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLT-----SLPALpPELRTLEVSGNQLTSLPVlppgllelsifsNPLTHLPAl 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   464 -KSLAYLRLGKNKFRIIPQgLPGSIEELYLENNQIEEI----TEICfnhtrkinvIVLRYNkieeNRIAPLAWInQENLE 538
Cdd:PRK15387 281 pSGLCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLASLpalpSELC---------KLWAYN----NQLTSLPTL-PSGLQ 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   539 SIDLSYNKLYHVPSyLPKSLLHLVLLGNQIERIPGyvfghMEPGLEYLYLSFNKLaddgmdrVSFYGAYHSLRELFLDHN 618
Cdd:PRK15387 346 ELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLPA-----LPSGLKELIVSGNRL-------TSLPVLPSELKELMVSGN 412

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4557543   619 DLKSIPPGIQEMKALHFLRlnNNKIRniLPEEICNAEEDDDSNLEHLHLENNYIK-IREIPS 679
Cdd:PRK15387 413 RLTSLPMLPSGLLSLSVYR--NQLTR--LPESLIHLSSETTVNLEGNPLSERTLQaLREITS 470
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
316-455 1.63e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 1.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   316 LPSGCSlsyrTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAfngLPNLERLDLSKNNITssgIGPKAfkLLKKL 395
Cdd:PRK15370 302 LPSGIT----HLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQIT---VLPET--LPPTI 369

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4557543   396 MRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDE---ESLSDLNQLVTLELEGNNLSEANV 455
Cdd:PRK15370 370 TTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPEslpHFRGEGPQPTRIIVEYNPFSERTI 432
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 334-673 2.01e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.03  E-value: 2.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  334 LTQIPPLTAPQITSLEltGNSIASIPDEAFNGLPNLERldlSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQlp 413
Cdd:COG5238  15 LLSANPATTEQSELTK--RATIVNLRSYHLHGGAILLA---RYLQSRSSITQYLRFEGQGDPGLNPVALEKAAEAFPT-- 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  414 stlEELKVNENNLQAIDEESLSDLNQLVT-----LELEGNNLSEANVNPLA-----------FKPLKSLAYLRLGKNKFR 477
Cdd:COG5238  88 ---QLLVVDWEGAEEVSPVALAETATAVAtpppdLRRIMAKTLEDSLILYLalprrinliqvLKDPLGGNAVHLLGLAAR 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  478 I--------IPQGLPGSIEELYLENNQIEE--ITEICfNHTRK---INVIVLRYNKIEENRIAPLAWINQEN--LESIDL 542
Cdd:COG5238 165 LgllaaismAKALQNNSVETVYLGCNQIGDegIEELA-EALTQnttVTTLWLKRNPIGDEGAEILAEALKGNksLTTLDL 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  543 SYNK-----LYHVPSYL--PKSLLHLVLLGNQIEripgyvfghmEPGLEYL--YLSFNKladdgmdrvsfygayhSLREL 613
Cdd:COG5238 244 SNNQigdegVIALAEALknNTTVETLYLSGNQIG----------AEGAIALakALQGNT----------------TLTSL 297

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4557543  614 FLDHNDL-----KSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEdDDSNLEHLHLENNYIK 673
Cdd:COG5238 298 DLSVNRIgdegaIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQ-ENTTLHSLDLSDNQIG 361
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 490-672 8.84e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 8.84e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  490 LYLENNQIEEITEicFNHTRKINVIVLRYNKIEenRIaplawinqENLESIdlsynklyhvpsylpKSLLHLVLLGNQIE 569
Cdd:cd21340   7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKIT--KI--------ENLEFL---------------TNLTHLYLQNNQIE 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  570 RIPGyvFGHMePGLEYLYLSFNKLAddgmdRVSFYGAYHSLRELFLDHNDLksiPPGiQEM-----------KALHFLRL 638
Cdd:cd21340  60 KIEN--LENL-VNLKKLYLGGNRIS-----VVEGLENLTNLEELHIENQRL---PPG-EKLtfdprslaalsNSLRVLNI 127

                       170       180       190
                ....*....|....*....|....*....|....
gi 4557543  639 NNNKIRNILPEEICnaeedddSNLEHLHLENNYI 672
Cdd:cd21340 128 SGNNIDSLEPLAPL-------RNLEQLDASNNQI 154
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
316-458 3.28e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.55  E-value: 3.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   316 LPSGcslsYRTISCINAMLTQIPPLTApQITSLELTGNSIASIPdeafnGLPN-LERLDLSKNNITSSGIGPKAfklLKK 394
Cdd:PRK15387 340 LPSG----LQELSVSDNQLASLPTLPS-ELYKLWAYNNRLTSLP-----ALPSgLKELIVSGNRLTSLPVLPSE---LKE 406

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4557543   395 LMrlnMDGNNLIQIPsQLPSTLEELKVNENNLQAIdEESLSDLNQLVTLELEGNNLSEANVNPL 458
Cdd:PRK15387 407 LM---VSGNRLTSLP-MLPSGLLSLSVYRNQLTRL-PESLIHLSSETTVNLEGNPLSERTLQAL 465
LRR_8 pfam13855
Leucine rich repeat;
536-593 4.71e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.71e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4557543    536 NLESIDLSYNKLYHVPSYLPKSLLHLVLL---GNQIERIPGYVFGHMePGLEYLYLSFNKL 593
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLdlsNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
414-476 5.90e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 5.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4557543    414 STLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEanVNPLAFKPLKSLAYLRLGKNKF 476
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
557-620 7.54e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 7.54e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4557543    557 SLLHLVLLGNQIERIPGYVFGHMePGLEYLYLSFNKLadDGMDRVSFYGaYHSLRELFLDHNDL 620
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGL-SNLKVLDLSNNLL--TTLSPGAFSG-LPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 318-547 7.68e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 7.68e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  318 SGCSLSYRTISCINAMLTQIPPLTapqitSLELTGNSIASIPD------EAFNGLPNLERLDLSKNNITSSGIGPkaFKL 391
Cdd:cd00116  31 EGNTLGEEAAKALASALRPQPSLK-----ELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGV--LES 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  392 LkklmrlnmdgnnliqipsQLPSTLEELKVNENNLQ----AIDEESLSDLN-QLVTLELEGNNLSEANVNPLA--FKPLK 464
Cdd:cd00116 104 L------------------LRSSSLQELKLNNNGLGdrglRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAkaLRANR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  465 SLAYLRLGKNK-----FRIIPQGLPGS--IEELYLENNQIEE----ITEICFNHTRKINVIVLRYNKIEENRIAPLAWIN 533
Cdd:cd00116 166 DLKELNLANNGigdagIRALAEGLKANcnLEVLDLNNNGLTDegasALAETLASLKSLEVLNLGDNNLTDAGAAALASAL 245

                       250
                ....*....|....*..
gi 4557543  534 QEN---LESIDLSYNKL 547
Cdd:cd00116 246 LSPnisLLTLSLSCNDI 262
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 492-694 7.88e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 7.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  492 LENNQIEEITEICFNHTRKINVIVlrynkieenRIAPLAWINQENLESIDLSYNKLYH-----VPSYLPKSLL-HLVL-- 563
Cdd:cd00116  47 LRPQPSLKELCLSLNETGRIPRGL---------QSLLQGLTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLqELKLnn 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  564 --LGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVS-FYGAYHSLRELFLDHNDLKsiPPGI----QEMKA---L 633
Cdd:cd00116 118 ngLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAkALRANRDLKELNLANNGIG--DAGIralaEGLKAncnL 195

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4557543  634 HFLRLNNNKIRNILPEEICNAEEDDDSnLEHLHLENNyiKIREIPSYTFSCIRSYSSIVLK 694
Cdd:cd00116 196 EVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDN--NLTDAGAAALASALLSPNISLL 253
LRR_8 pfam13855
Leucine rich repeat;
581-643 2.81e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.81e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4557543    581 PGLEYLYLSFNKLadDGMDRVSFYGAyHSLRELFLDHNDLKSIPPG-IQEMKALHFLRLNNNKI 643
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLDDGAFKGL-SNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 342-645 4.61e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.32  E-value: 4.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  342 APQITSLELTGNSI-----ASIPDEAFNGLPNLERLDLSKNNITSSGIgpkafKLLKKLMRLNmdgnnliqipsqlpSTL 416
Cdd:COG5238 150 PLGGNAVHLLGLAArlgllAAISMAKALQNNSVETVYLGCNQIGDEGI-----EELAEALTQN--------------TTV 210

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  417 EELKVNENNlqaIDEES-------LSDLNQLVTLELEGNNLSEANVNPLAfkplkslAYLRLGKNkfriipqglpgsIEE 489
Cdd:COG5238 211 TTLWLKRNP---IGDEGaeilaeaLKGNKSLTTLDLSNNQIGDEGVIALA-------EALKNNTT------------VET 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  490 LYLENNQIEEITEICFNHTRKINvIVLRYNKIEENRIAPLAWIN-----QEN--LESIDLSYNKLyhvpsylpksllhlv 562
Cdd:COG5238 269 LYLSGNQIGAEGAIALAKALQGN-TTLTSLDLSVNRIGDEGAIAlaeglQGNktLHTLNLAYNGI--------------- 332

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  563 llGNQ-IERIPGYVFGHmePGLEYLYLSFNKLADDGMDRVSFYGAYH-SLRELFLDHNDL-----KSIPPGIQEMKaLHF 635
Cdd:COG5238 333 --GAQgAIALAKALQEN--TTLHSLDLSDNQIGDEGAIALAKYLEGNtTLRELNLGKNNIgkqgaEALIDALQTNR-LHT 407

                       330
                ....*....|
gi 4557543  636 LRLNNNKIRN 645
Cdd:COG5238 408 LILDGNLIGA 417
LRR_8 pfam13855
Leucine rich repeat;
486-547 4.78e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 4.78e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4557543    486 SIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIeeNRIAPLAWINQENLESIDLSYNKL 547
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 116-211 1.09e-04

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 45.07  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543    116 WSPEPC---TTCLCSDGRVLcdETMCH--PQRCPQT-----VIPEGECCPVCSATVSysllsgiaLNDRNEFSGDSSEQR 185
Cdd:pfam14828 186 VGPEACsdpSGCGCGNDENL--ERICAnvLQRCPPPhclspLRPEGHCCDVCGAIVS--------LDYSSCFDLQTYRAR 255

                          90       100       110
                  ....*....|....*....|....*....|.
gi 4557543    186 eptnLLHKQLPPP-----QVGMDRIVRKEAL 211
Cdd:pfam14828 256 ----LRHLFLALPkykgvQLAVSKVGKDQRL 282
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 342-476 1.92e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 1.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  342 APQITSLELTGNSIASIPDE----AFNGLPNLERLDLSKNNITSSGIGP--KAFKLLKKLMRLNMDGNN--------LIQ 407
Cdd:cd00116 136 PPALEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNLEVLDLNNNGltdegasaLAE 215

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4557543  408 IPSQLPStLEELKVNENNL-----QAIDEESLSDLNQLVTLELEGNNLSEANVNPLA--FKPLKSLAYLRLGKNKF 476
Cdd:cd00116 216 TLASLKS-LEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAevLAEKESLLELDLRGNKF 290
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
103-143 2.16e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 39.85  E-value: 2.16e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 4557543     103 CLVKGITMYNKAVWSpEPCTTCLCSDGRVLCDETMCHPQRC 143
Cdd:smart00215   1 CWNNGSYYPPGAKWD-DDCNRCTCLNGRVSCTKVWCGPKPC 40
LRR_8 pfam13855
Leucine rich repeat;
609-672 4.07e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 4.07e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4557543    609 SLRELFLDHNDLKSIPPGI-QEMKALHFLRLNNNKIRNILPEEIcnaeeDDDSNLEHLHLENNYI 672
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAF-----SGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 463-676 1.35e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  463 LKSLAYLRL-GKNKFRIIPQGLPGSIEELYLENNQIEEITEicFNHTRKINVIVLRYNKIEenRIaplawinqENLESId 541
Cdd:cd21340   1 LKRITHLYLnDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIE--KI--------ENLENL- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  542 lsynklyhvpsylpKSLLHLVLLGNQIERIPGyvfghME--PGLEYLYLSFNKLADDGM---DRVSFYGAYHSLRELFLD 616
Cdd:cd21340  68 --------------VNLKKLYLGGNRISVVEG-----LEnlTNLEELHIENQRLPPGEKltfDPRSLAALSNSLRVLNIS 128

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4557543  617 HNDLKSIPPgIQEMKALHFLRLNNNKIRNIlpEEICNAEEdDDSNLEHLHLENNYI----KIRE 676
Cdd:cd21340 129 GNNIDSLEP-LAPLRNLEQLDASNNQISDL--EELLDLLS-SWPSLRELDLTGNPVckkpKYRD 188
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 416-643 1.60e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 1.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  416 LEELKVNENNLqaiDEESLSDL-------NQLVTLELEGNNLSEANVN----PLAFKPLKSLAYLRLGKNKFRIIPQGL- 483
Cdd:cd00116  25 LQVLRLEGNTL---GEEAAKALasalrpqPSLKELCLSLNETGRIPRGlqslLQGLTKGCGLQELDLSDNALGPDGCGVl 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  484 -----PGSIEELYLENNQIEE-----ITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQEN--LESIDLSYNKLYH-- 549
Cdd:cd00116 102 esllrSSSLQELKLNNNGLGDrglrlLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANrdLKELNLANNGIGDag 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  550 VPSYLP-----KSLLHLVLLGNQIERIPGYVFGHM---EPGLEYLYLSFNKLADDGMDRV--SFYGAYHSLRELFLDHND 619
Cdd:cd00116 182 IRALAEglkanCNLEVLDLNNNGLTDEGASALAETlasLKSLEVLNLGDNNLTDAGAAALasALLSPNISLLTLSLSCND 261

                       250       260
                ....*....|....*....|....*....
gi 4557543  620 L-----KSIPPGIQEMKALHFLRLNNNKI 643
Cdd:cd00116 262 ItddgaKDLAEVLAEKESLLELDLRGNKF 290
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 343-420 1.82e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 1.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  343 PQITSLELTGNSI----ASIPDEAFNGLPNLERLDLSKNNITSSGigpkAFKLLK-----KLMRLNMDGNNL-IQIPSQL 412
Cdd:COG5238 348 TTLHSLDLSDNQIgdegAIALAKYLEGNTTLRELNLGKNNIGKQG----AEALIDalqtnRLHTLILDGNLIgAEAQQRL 423


                ....*...
gi 4557543  413 PSTLEELK 420
Cdd:COG5238 424 EQLLERIK 431
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 343-382 1.91e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 4557543    343 PQITSLELTGNSIASIPdeAFNGLPNLERLDLSKNNITSS 382
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITD 38
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 361-453 2.81e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 2.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543  361 EAFNGLPNLERLDLSKNNITSSGIG--PKAFKLLKKLMRLNMDGNNLIQIP-----SQLPS---TLEELKVNENNLQAID 430
Cdd:cd00116 187 EGLKANCNLEVLDLNNNGLTDEGASalAETLASLKSLEVLNLGDNNLTDAGaaalaSALLSpniSLLTLSLSCNDITDDG 266

                        90       100
                ....*....|....*....|....*..
gi 4557543  431 EESL----SDLNQLVTLELEGNNLSEA 453
Cdd:cd00116 267 AKDLaevlAEKESLLELDLRGNKFGEE 293
PLN03150 PLN03150
hypothetical protein; Provisional
 347-416 3.81e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 3.81e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557543   347 SLELTGNSIASIPDEAFNGLPNLERLDLSKNNItsSGIGPKAFKLLKKLMRLNMDGNNLiqiPSQLPSTL 416
Cdd:PLN03150 446 SINLSGNSIRGNIPPSLGSITSLEVLDLSYNSF--NGSIPESLGQLTSLRILNLNGNSL---SGRVPAAL 510
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 367-414 6.24e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 6.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 4557543    367 PNLERLDLSKNNITSSGigpkAFKLLKKLMRLNMDGNNLIQIPSQLPS 414
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP----PLAKLPNLETLDLSGNNKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 609-646 9.54e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 9.54e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4557543    609 SLRELFLDHNDLKSIPPgIQEMKALHFLRL-NNNKIRNI 646
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP-LAKLPNLETLDLsGNNKITDL 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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