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Conserved domains on  [gi|2172664122|ref|NP_001386109|]
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WD repeat-containing protein 75 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
19-315 1.22e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122  19 RRAVFSVDSKYIFCVSGD-FIKVYSTATEECVHILRGHKHVVSGILINPNNHLqLYSCSFDGTIKLWDYLDGILIKTFTV 97
Cdd:COG2319   124 RSVAFSPDGKTLASGSADgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122  98 gpklHALFIpahaEDTVFltinkeDPDIFQLVS------VKLpkstsRNVEAKELTFVLDYINKSPKSIAFGNEGEYVAA 171
Cdd:COG2319   203 ----HTGAV----RSVAF------SPDGKLLASgsadgtVRL-----WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 172 V-RDFYLSVYFLKKKKtCNFTLPSTKNKKNArnkftcVACHPKEDCIASGHMDGKIRLWRnfhddkLYTYTCLHW---HH 247
Cdd:COG2319   264 GsADGTVRLWDLATGE-LLRTLTGHSGGVNS------VAFSPDGKLLASGSDDGTVRLWD------LATGKLLRTltgHT 330

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2172664122 248 DMVMDLAFTVTGTSLLSGGQECVLVEWRDGSEKNKEFLPRLGSAIEHISVSPAGDLFCTSHSDNKITV 315
Cdd:COG2319   331 GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
206-527 2.30e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 2.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 206 TCVACHPKEDCIASGHMDGKIRLWRNFHDDKLYTytcLHWHHDMVMDLAFTVTGTSLLSGGQECVLVEWRDGSEKNKEFL 285
Cdd:COG2319   124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT---LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 286 PRLGSAIEHISVSPAGDLFCTSHSDNKITVIhrNLDASAVIQGLVKDRSISTGLMVDPRTKALVLNGKPGHLQFYSLQSD 365
Cdd:COG2319   201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 366 KQLYNLDIIQQEyindqgliqieLTKAAFGCSGSWLATVEQRQenenelelQMKLWNYSKKTQGFVLNtkismPHDDHIT 445
Cdd:COG2319   279 ELLRTLTGHSGG-----------VNSVAFSPDGKLLASGSDDG--------TVRLWDLATGKLLRTLT-----GHTGAVR 334

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 446 ALCFNNAENYekpiLVTASRDGHFKVWVLTDDSDIYKkaigwtcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 524
Cdd:COG2319   335 SVAFSPDGKT----LASGSDDGTVRLWDLATGELLRT--------LTG--HTGAVTSVAFSPDGRTLASgSADGTVRLWD 400


                  ...
gi 2172664122 525 SET 527
Cdd:COG2319   401 LAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
19-315 1.22e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122  19 RRAVFSVDSKYIFCVSGD-FIKVYSTATEECVHILRGHKHVVSGILINPNNHLqLYSCSFDGTIKLWDYLDGILIKTFTV 97
Cdd:COG2319   124 RSVAFSPDGKTLASGSADgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122  98 gpklHALFIpahaEDTVFltinkeDPDIFQLVS------VKLpkstsRNVEAKELTFVLDYINKSPKSIAFGNEGEYVAA 171
Cdd:COG2319   203 ----HTGAV----RSVAF------SPDGKLLASgsadgtVRL-----WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 172 V-RDFYLSVYFLKKKKtCNFTLPSTKNKKNArnkftcVACHPKEDCIASGHMDGKIRLWRnfhddkLYTYTCLHW---HH 247
Cdd:COG2319   264 GsADGTVRLWDLATGE-LLRTLTGHSGGVNS------VAFSPDGKLLASGSDDGTVRLWD------LATGKLLRTltgHT 330

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2172664122 248 DMVMDLAFTVTGTSLLSGGQECVLVEWRDGSEKNKEFLPRLGSAIEHISVSPAGDLFCTSHSDNKITV 315
Cdd:COG2319   331 GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-313 3.50e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 3.50e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122  23 FSVDSKYIFCVSGD-FIKVYSTATEECVHILRGHKHVVSGILINPNNHlQLYSCSFDGTIKLWDYLDGILIKTFTvgpkl 101
Cdd:cd00200    17 FSPDGKLLATGSGDgTIKVWDLETGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETGECVRTLT----- 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 102 halfipAHAEDTVFLTINKEDpdifQLVSvklpkSTSR-------NVEAKELTFVLDYINKSPKSIAFGNEGEYVA-AVR 173
Cdd:cd00200    91 ------GHTSYVSSVAFSPDG----RILS-----SSSRdktikvwDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAsSSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 174 DFYLSVYFLKKKKTC-NFTLPStknkknarNKFTCVACHPKEDCIASGHMDGKIRLWRNFHDDKLYTYTClhwHHDMVMD 252
Cdd:cd00200   156 DGTIKLWDLRTGKCVaTLTGHT--------GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---HENGVNS 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2172664122 253 LAFTVTGTSLLSGGQECVLVEWRDGSEKNKEFLPRLGSAIEHISVSPAGDLFCTSHSDNKI 313
Cdd:cd00200   225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
206-527 2.30e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 2.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 206 TCVACHPKEDCIASGHMDGKIRLWRNFHDDKLYTytcLHWHHDMVMDLAFTVTGTSLLSGGQECVLVEWRDGSEKNKEFL 285
Cdd:COG2319   124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT---LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 286 PRLGSAIEHISVSPAGDLFCTSHSDNKITVIhrNLDASAVIQGLVKDRSISTGLMVDPRTKALVLNGKPGHLQFYSLQSD 365
Cdd:COG2319   201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 366 KQLYNLDIIQQEyindqgliqieLTKAAFGCSGSWLATVEQRQenenelelQMKLWNYSKKTQGFVLNtkismPHDDHIT 445
Cdd:COG2319   279 ELLRTLTGHSGG-----------VNSVAFSPDGKLLASGSDDG--------TVRLWDLATGKLLRTLT-----GHTGAVR 334

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 446 ALCFNNAENYekpiLVTASRDGHFKVWVLTDDSDIYKkaigwtcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 524
Cdd:COG2319   335 SVAFSPDGKT----LASGSDDGTVRLWDLATGELLRT--------LTG--HTGAVTSVAFSPDGRTLASgSADGTVRLWD 400


                  ...
gi 2172664122 525 SET 527
Cdd:COG2319   401 LAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 206-534 2.37e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 2.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 206 TCVACHPKEDCIASGHMDGKIRLWRNFHDDKLYTYTClhwHHDMVMDLAFTVTGTSLLSGGQE-CVLVEWRDGSEKNKEF 284
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDkTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 285 LprlG--SAIEHISVSPAGDLFCTSHSDNKITVIHrnldasaviqglvkdrsistglmVDPRTKALVLNGKPGHLQFYSL 362
Cdd:cd00200    90 T---GhtSYVSSVAFSPDGRILSSSSRDKTIKVWD-----------------------VETGKCLTTLRGHTDWVNSVAF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 363 QSDKQlynldiiqqeyindqgliqieltkaaFGCSGSWLATVeqrqenenelelqmKLWNyskkTQGFVLNTKISMpHDD 442
Cdd:cd00200   144 SPDGT--------------------------FVASSSQDGTI--------------KLWD----LRTGKCVATLTG-HTG 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 443 HITALCFNNAENyekpILVTASRDGHFKVWVLTDDSdiykkaigWTCDFVGsyHKYQATNCCFSEDGSLLAVSFEEIVT- 521
Cdd:cd00200   179 EVNSVAFSPDGE----KLLSSSSDGTIKLWDLSTGK--------CLGTLRG--HENGVNSVAFSPDGYLLASGSEDGTIr 244

                         330
                  ....*....|...
gi 2172664122 522 IWDSETWELKCTF 534
Cdd:cd00200   245 VWDLRTGECVQTL 257
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 45-85 3.62e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.62e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2172664122   45 TEECVHILRGHKHVVSGILINPNNHLqLYSCSFDGTIKLWD 85
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
47-85 3.97e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 3.97e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2172664122  47 ECVHILRGHKHVVSGILINPNNHLqLYSCSFDGTIKLWD 85
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
19-315 1.22e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122  19 RRAVFSVDSKYIFCVSGD-FIKVYSTATEECVHILRGHKHVVSGILINPNNHLqLYSCSFDGTIKLWDYLDGILIKTFTV 97
Cdd:COG2319   124 RSVAFSPDGKTLASGSADgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122  98 gpklHALFIpahaEDTVFltinkeDPDIFQLVS------VKLpkstsRNVEAKELTFVLDYINKSPKSIAFGNEGEYVAA 171
Cdd:COG2319   203 ----HTGAV----RSVAF------SPDGKLLASgsadgtVRL-----WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 172 V-RDFYLSVYFLKKKKtCNFTLPSTKNKKNArnkftcVACHPKEDCIASGHMDGKIRLWRnfhddkLYTYTCLHW---HH 247
Cdd:COG2319   264 GsADGTVRLWDLATGE-LLRTLTGHSGGVNS------VAFSPDGKLLASGSDDGTVRLWD------LATGKLLRTltgHT 330

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2172664122 248 DMVMDLAFTVTGTSLLSGGQECVLVEWRDGSEKNKEFLPRLGSAIEHISVSPAGDLFCTSHSDNKITV 315
Cdd:COG2319   331 GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-313 3.50e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 3.50e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122  23 FSVDSKYIFCVSGD-FIKVYSTATEECVHILRGHKHVVSGILINPNNHlQLYSCSFDGTIKLWDYLDGILIKTFTvgpkl 101
Cdd:cd00200    17 FSPDGKLLATGSGDgTIKVWDLETGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETGECVRTLT----- 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 102 halfipAHAEDTVFLTINKEDpdifQLVSvklpkSTSR-------NVEAKELTFVLDYINKSPKSIAFGNEGEYVA-AVR 173
Cdd:cd00200    91 ------GHTSYVSSVAFSPDG----RILS-----SSSRdktikvwDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAsSSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 174 DFYLSVYFLKKKKTC-NFTLPStknkknarNKFTCVACHPKEDCIASGHMDGKIRLWRNFHDDKLYTYTClhwHHDMVMD 252
Cdd:cd00200   156 DGTIKLWDLRTGKCVaTLTGHT--------GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---HENGVNS 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2172664122 253 LAFTVTGTSLLSGGQECVLVEWRDGSEKNKEFLPRLGSAIEHISVSPAGDLFCTSHSDNKI 313
Cdd:cd00200   225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-371 1.08e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.31  E-value: 1.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122  48 CVHILRGHKHVVSGILINPNNHLqLYSCSFDGTIKLWDYLDGILIKTFTVgpklHALFIpahaedtvfltinkedpdifq 127
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTLKG----HTGPV--------------------- 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 128 lvsvklpkstsrnveakeltfvldyinkspKSIAFGNEGEYVAAV-RDFYLSVYFLKKKKtCNFTLpstknkKNARNKFT 206
Cdd:cd00200    55 ------------------------------RDVAASADGTYLASGsSDKTIRLWDLETGE-CVRTL------TGHTSYVS 97

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 207 CVACHPKEDCIASGHMDGKIRLWRNFHDDKLYTYTClhwHHDMVMDLAFTVTGTSLLSGGQECVLVEWRDGSEKNKEFLP 286
Cdd:cd00200    98 SVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG---HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT 174

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 287 RLGSAIEHISVSPAGDLFCTSHSDNKITVIhrNLDASAVIQGLVKDRSISTGLMVDPRTKALVLNGKPGHLQFYSLQSDK 366
Cdd:cd00200   175 GHTGEVNSVAFSPDGEKLLSSSSDGTIKLW--DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252


                  ....*
gi 2172664122 367 QLYNL 371
Cdd:cd00200   253 CVQTL 257
WD40 COG2319
WD40 repeat [General function prediction only];
13-472 1.38e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 1.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122  13 GSRLNFRRAVFSVDSKYIFCVSGDF-IKVYSTATEECVHILRGHKHVVSGILINPNNHLqLYSCSFDGTIKLWDYLDGIL 91
Cdd:COG2319    76 GHTAAVLSVAFSPDGRLLASASADGtVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122  92 IKTFTvgpklhalfipAHAedtvfltinkedpdifqlvsvklpkstsrnveakeltfvlDYINkspkSIAFGNEGEYVAA 171
Cdd:COG2319   155 LRTLT-----------GHS----------------------------------------GAVT----SVAFSPDGKLLAS 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 172 V-RDFYLSVYFLKKKKtCNFTLPSTKNKknarnkFTCVACHPKEDCIASGHMDGKIRLWRnfhddkLYTYTCLH---WHH 247
Cdd:COG2319   180 GsDDGTVRLWDLATGK-LLRTLTGHTGA------VRSVAFSPDGKLLASGSADGTVRLWD------LATGKLLRtltGHS 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 248 DMVMDLAFTVTGTSLLSGGQECVLVEWRDGSEKNKEFLPRLGSAIEHISVSPAGDLFCTSHSDNKITVIhrNLDASAVIQ 327
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLR 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 328 GLvkdrsistglmvdprtkalvlngkPGHlqfyslqsdkqlynldiiqqeyindqgliQIELTKAAFGCSGSWLATVEQR 407
Cdd:COG2319   325 TL------------------------TGH-----------------------------TGAVRSVAFSPDGKTLASGSDD 351

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2172664122 408 QenenelelQMKLWNYSKKTQGFVLNTkismpHDDHITALCFNNAENYekpiLVTASRDGHFKVW 472
Cdd:COG2319   352 G--------TVRLWDLATGELLRTLTG-----HTGAVTSVAFSPDGRT----LASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-230 7.29e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.00  E-value: 7.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122  23 FSVDSKYIFCVSGDF-IKVYSTATEECVHILRGHKHVVSGILINPNNHLqLYSCSFDGTIKLWDYLDGILIKTFTvGPKL 101
Cdd:cd00200   101 FSPDGRILSSSSRDKtIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF-VASSSQDGTIKLWDLRTGKCVATLT-GHTG 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 102 HALFIPAHAEDTVFL------TINKEDPDIFQLVsvklpkstsrnveaKELTFVLDYINkspkSIAFGNEGEYVA-AVRD 174
Cdd:cd00200   179 EVNSVAFSPDGEKLLssssdgTIKLWDLSTGKCL--------------GTLRGHENGVN----SVAFSPDGYLLAsGSED 240

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2172664122 175 FYLSVYFLKKKKtCNFTLPSTKnkknarNKFTCVACHPKEDCIASGHMDGKIRLWR 230
Cdd:cd00200   241 GTIRVWDLRTGE-CVQTLSGHT------NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
206-527 2.30e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 2.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 206 TCVACHPKEDCIASGHMDGKIRLWRNFHDDKLYTytcLHWHHDMVMDLAFTVTGTSLLSGGQECVLVEWRDGSEKNKEFL 285
Cdd:COG2319   124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT---LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 286 PRLGSAIEHISVSPAGDLFCTSHSDNKITVIhrNLDASAVIQGLVKDRSISTGLMVDPRTKALVLNGKPGHLQFYSLQSD 365
Cdd:COG2319   201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 366 KQLYNLDIIQQEyindqgliqieLTKAAFGCSGSWLATVEQRQenenelelQMKLWNYSKKTQGFVLNtkismPHDDHIT 445
Cdd:COG2319   279 ELLRTLTGHSGG-----------VNSVAFSPDGKLLASGSDDG--------TVRLWDLATGKLLRTLT-----GHTGAVR 334

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 446 ALCFNNAENYekpiLVTASRDGHFKVWVLTDDSDIYKkaigwtcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 524
Cdd:COG2319   335 SVAFSPDGKT----LASGSDDGTVRLWDLATGELLRT--------LTG--HTGAVTSVAFSPDGRTLASgSADGTVRLWD 400


                  ...
gi 2172664122 525 SET 527
Cdd:COG2319   401 LAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
208-546 1.08e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 1.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 208 VACHPKEDCIASGHMDGKIRLWRnfhDDKLYTYTCLHWHHDMVMDLAFTVTGTSLLSGGQECVLVEWRDGSEKNKEFLPR 287
Cdd:COG2319    84 VAFSPDGRLLASASADGTVRLWD---LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 288 LGSAIEHISVSPAGDLFCTSHSDNkiTVIHRNLDASAVIQGLVKDRSISTGLMVDPRTKALVLNGKPGHLQFYSLQSDKQ 367
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDG--TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 368 LYNLDIiQQEYINDqgliqieltkAAFgcS--GSWLATVEQRQenenelelQMKLWNYSKKTQGFVLNTkismpHDDHIT 445
Cdd:COG2319   239 LRTLTG-HSGSVRS----------VAF--SpdGRLLASGSADG--------TVRLWDLATGELLRTLTG-----HSGGVN 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 446 ALCFNNAENYekpiLVTASRDGHFKVWvltddsDIYKKAIGWTcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 524
Cdd:COG2319   293 SVAFSPDGKL----LASGSDDGTVRLW------DLATGKLLRT--LTG--HTGAVRSVAFSPDGKTLASgSDDGTVRLWD 358

                         330       340
                  ....*....|....*....|..
gi 2172664122 525 SETWELKCTFCQRAGKIRHLCF 546
Cdd:COG2319   359 LATGELLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
217-569 6.04e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 6.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 217 IASGHMDGKIRLWRNFHDDKLYTytcLHWHHDMVMDLAFTVTGTSLLSGGQECVLVEWRDGSEKNKEFLPRLGSAIEHIS 296
Cdd:COG2319     9 LAAASADLALALLAAALGALLLL---LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 297 VSPAGDLFCTSHSDNKITVihRNLDASAVIQGLVKDRSISTGLMVDPRTKALVLNGKPGHLQFYSLQSDKQLYNLDIiQQ 376
Cdd:COG2319    86 FSPDGRLLASASADGTVRL--WDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG-HS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 377 EYINDqgliqieltkAAFGCSGSWLATVEQRQenenelelQMKLWNYSKKTQGFVLNtkismPHDDHITALCFNnaenye 456
Cdd:COG2319   163 GAVTS----------VAFSPDGKLLASGSDDG--------TVRLWDLATGKLLRTLT-----GHTGAVRSVAFS------ 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 457 kP---ILVTASRDGHFKVWvltddsDIYKKAIGWTcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWDSETWELKC 532
Cdd:COG2319   214 -PdgkLLASGSADGTVRLW------DLATGKLLRT--LTG--HSGSVRSVAFSPDGRLLASgSADGTVRLWDLATGELLR 282

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2172664122 533 TFCQRAGKIRHLCF---GRltcskYLLGTTENNLLCCWNL 569
Cdd:COG2319   283 TLTGHSGGVNSVAFspdGK-----LLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-96 4.85e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 4.85e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2172664122  19 RRAVFSVDSKYIFCVSGD-FIKVYSTATEECVHILRGHKHVVSGILINPNNHLqLYSCSFDGTIKLWDYLDGILIKTFT 96
Cdd:cd00200   181 NSVAFSPDGEKLLSSSSDgTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-LASGSEDGTIRVWDLRTGECVQTLS 258
WD40 COG2319
WD40 repeat [General function prediction only];
19-85 1.82e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 1.82e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2172664122  19 RRAVFSVDSKYIFCVSGD-FIKVYSTATEECVHILRGHKHVVSGILINPNNHLqLYSCSFDGTIKLWD 85
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDgTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT-LASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 206-534 2.37e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 2.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 206 TCVACHPKEDCIASGHMDGKIRLWRNFHDDKLYTYTClhwHHDMVMDLAFTVTGTSLLSGGQE-CVLVEWRDGSEKNKEF 284
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDkTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 285 LprlG--SAIEHISVSPAGDLFCTSHSDNKITVIHrnldasaviqglvkdrsistglmVDPRTKALVLNGKPGHLQFYSL 362
Cdd:cd00200    90 T---GhtSYVSSVAFSPDGRILSSSSRDKTIKVWD-----------------------VETGKCLTTLRGHTDWVNSVAF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 363 QSDKQlynldiiqqeyindqgliqieltkaaFGCSGSWLATVeqrqenenelelqmKLWNyskkTQGFVLNTKISMpHDD 442
Cdd:cd00200   144 SPDGT--------------------------FVASSSQDGTI--------------KLWD----LRTGKCVATLTG-HTG 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 443 HITALCFNNAENyekpILVTASRDGHFKVWVLTDDSdiykkaigWTCDFVGsyHKYQATNCCFSEDGSLLAVSFEEIVT- 521
Cdd:cd00200   179 EVNSVAFSPDGE----KLLSSSSDGTIKLWDLSTGK--------CLGTLRG--HENGVNSVAFSPDGYLLASGSEDGTIr 244

                         330
                  ....*....|...
gi 2172664122 522 IWDSETWELKCTF 534
Cdd:cd00200   245 VWDLRTGECVQTL 257
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-85 3.37e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 3.37e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2172664122  22 VFSVDSKYIFCVSGDF-IKVYSTATEECVHILRGHKHVVSGILINPNNHlQLYSCSFDGTIKLWD 85
Cdd:cd00200   226 AFSPDGYLLASGSEDGtIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 45-85 3.62e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.62e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2172664122   45 TEECVHILRGHKHVVSGILINPNNHLqLYSCSFDGTIKLWD 85
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
47-85 3.97e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 3.97e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2172664122  47 ECVHILRGHKHVVSGILINPNNHLqLYSCSFDGTIKLWD 85
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 295-574 2.67e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 2.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 295 ISVSPAGDLFCTSHSDNKITVIhrNLDASAVIQGLVKDRSISTGLMVDPRTKALVLNGKPGHLQFYSLQSDKQLYNL--- 371
Cdd:cd00200    15 VAFSPDGKLLATGSGDGTIKVW--DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLtgh 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 372 --DIIQQEYINDQGLIqieltkaafgCSGSWLATVeqrqenenelelqmKLWNYSKKTQGFVLNTkismpHDDHITALCF 449
Cdd:cd00200    93 tsYVSSVAFSPDGRIL----------SSSSRDKTI--------------KVWDVETGKCLTTLRG-----HTDWVNSVAF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 450 NNaenyEKPILVTASRDGHFKVWVLTDDSDIYKkaigwtcdFVGsyHKYQATNCCFSEDGSLLAVSFEE-IVTIWDSETW 528
Cdd:cd00200   144 SP----DGTFVASSSQDGTIKLWDLRTGKCVAT--------LTG--HTGEVNSVAFSPDGEKLLSSSSDgTIKLWDLSTG 209

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2172664122 529 ELKCTFCQRAGKIRHLCFgrLTCSKYLLGTTENNLLCCWNLLSCSM 574
Cdd:cd00200   210 KCLGTLRGHENGVNSVAF--SPDGYLLASGSEDGTIRVWDLRTGEC 253
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 440-571 1.02e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2172664122 440 HDDHITALCFNNAENYekpiLVTASRDGHFKVWVLTDDSDIYKkaigwtcdFVGSYHKYQATNCCfSEDGSLLAVSFEEI 519
Cdd:cd00200     8 HTGGVTCVAFSPDGKL----LATGSGDGTIKVWDLETGELLRT--------LKGHTGPVRDVAAS-ADGTYLASGSSDKT 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2172664122 520 VTIWDSETWELKCTFCQRAGKIRHLCFgrLTCSKYLLGTTENNLLCCWNLLS 571
Cdd:cd00200    75 IRLWDLETGECVRTLTGHTSYVSSVAF--SPDGRILSSSSRDKTIKVWDVET 124
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 206-229 4.22e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 4.22e-03
                           10        20
                   ....*....|....*....|....
gi 2172664122  206 TCVACHPKEDCIASGHMDGKIRLW 229
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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