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Conserved domains on  [gi|2173616070|ref|NP_001386224|]
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WD repeat-containing protein 53 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-273 4.22e-29

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 4.22e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070   6 TGGHSSSILCLNASKDGLVASGGEGGDLVAWGEDGTPVGHMQLEGADDVTSIVFSASCPTKLYASHGESISVLDVRSlKG 85
Cdd:COG2319    33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070  86 CLDHFHVNEEEINCLSLNETESLLASADDSGAIKILDLEKKKVTRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWS 165
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWD 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070 166 LQKARPVWitnlqedeteETEGPQTPgrllnpalAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCERELgfKGHTLGVS 245
Cdd:COG2319   191 LATGKLLR----------TLTGHTGA--------VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL--TGHSGSVR 250

                         250       260
                  ....*....|....*....|....*...
gi 2173616070 246 QVCFLPESHLLLTGGNDGKIRLWDVSGK 273
Cdd:COG2319   251 SVAFSPDGRLLASGSADGTVRLWDLATG 278
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-273 4.22e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 4.22e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070   6 TGGHSSSILCLNASKDGLVASGGEGGDLVAWGEDGTPVGHMQLEGADDVTSIVFSASCPTKLYASHGESISVLDVRSlKG 85
Cdd:COG2319    33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070  86 CLDHFHVNEEEINCLSLNETESLLASADDSGAIKILDLEKKKVTRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWS 165
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWD 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070 166 LQKARPVWitnlqedeteETEGPQTPgrllnpalAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCERELgfKGHTLGVS 245
Cdd:COG2319   191 LATGKLLR----------TLTGHTGA--------VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL--TGHSGSVR 250

                         250       260
                  ....*....|....*....|....*...
gi 2173616070 246 QVCFLPESHLLLTGGNDGKIRLWDVSGK 273
Cdd:COG2319   251 SVAFSPDGRLLASGSADGTVRLWDLATG 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-269 3.02e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 3.02e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070   8 GHSSSILCLNASKDG-LVASGGEGGDLVAWgEDGTPVGHMQLEG-ADDVTSIVFSASCPTKLYASHGESISVLDVRSLKg 85
Cdd:cd00200    49 GHTGPVRDVAASADGtYLASGSSDKTIRLW-DLETGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK- 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070  86 CLDHFHVNEEEINCLSLNETESLLASADDSGAIKILDLEKKKVTRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWS 165
Cdd:cd00200   127 CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWD 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070 166 LQKARpvWITNLQEDEteetegpqtpgrllnpALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCERELgfKGHTLGVS 245
Cdd:cd00200   206 LSTGK--CLGTLRGHE----------------NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL--SGHTNSVT 265

                         250       260
                  ....*....|....*....|....
gi 2173616070 246 QVCFLPESHLLLTGGNDGKIRLWD 269
Cdd:cd00200   266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-269 8.53e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 8.53e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2173616070  237 FKGHTLGVSQVCFLPESHLLLTGGNDGKIRLWD 269
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
237-269 5.06e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 5.06e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2173616070 237 FKGHTLGVSQVCFLPESHLLLTGGNDGKIRLWD 269
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-273 4.22e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 4.22e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070   6 TGGHSSSILCLNASKDGLVASGGEGGDLVAWGEDGTPVGHMQLEGADDVTSIVFSASCPTKLYASHGESISVLDVRSlKG 85
Cdd:COG2319    33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070  86 CLDHFHVNEEEINCLSLNETESLLASADDSGAIKILDLEKKKVTRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWS 165
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWD 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070 166 LQKARPVWitnlqedeteETEGPQTPgrllnpalAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCERELgfKGHTLGVS 245
Cdd:COG2319   191 LATGKLLR----------TLTGHTGA--------VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL--TGHSGSVR 250

                         250       260
                  ....*....|....*....|....*...
gi 2173616070 246 QVCFLPESHLLLTGGNDGKIRLWDVSGK 273
Cdd:COG2319   251 SVAFSPDGRLLASGSADGTVRLWDLATG 278
WD40 COG2319
WD40 repeat [General function prediction only];
8-272 4.80e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 4.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070   8 GHSSSILCLNASKDG-LVASGGEGGDLVAWG-EDGTPVGhmQLEG-ADDVTSIVFSASCPTKLYASHGESISVLDVRSLK 84
Cdd:COG2319   118 GHTGAVRSVAFSPDGkTLASGSADGTVRLWDlATGKLLR--TLTGhSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070  85 gCLDHFHVNEEEINCLSLNETESLLASADDSGAIKILDLEKKKVTRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLW 164
Cdd:COG2319   196 -LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSADGTVRLW 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070 165 SLQKARPV--------WITNLQ------------EDETEETEGPQTpGRLLNPALAHSISVASC-----GNIFSCGAEDG 219
Cdd:COG2319   274 DLATGELLrtltghsgGVNSVAfspdgkllasgsDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVafspdGKTLASGSDDG 352

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2173616070 220 KVRIFRVMGVKCERELgfKGHTLGVSQVCFLPESHLLLTGGNDGKIRLWDVSG 272
Cdd:COG2319   353 TVRLWDLATGELLRTL--TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
8-271 7.02e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 7.02e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070   8 GHSSSILCLNASKDG-LVASGGEGGDLVAWGEDGTPVGHMQLEGADDVTSIVFSASCPTKLYASHGESISVLDVRSLKgC 86
Cdd:COG2319    76 GHTAAVLSVAFSPDGrLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-L 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070  87 LDHFHVNEEEINCLSLNETESLLASADDSGAIKILDLEKKKVTRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWSL 166
Cdd:COG2319   155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDL 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070 167 QKARPVWITNLQEDEteetegpqtpgrllnpalAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCERELGfkGHTLGVSQ 246
Cdd:COG2319   234 ATGKLLRTLTGHSGS------------------VRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNS 293

                         250       260
                  ....*....|....*....|....*
gi 2173616070 247 VCFLPESHLLLTGGNDGKIRLWDVS 271
Cdd:COG2319   294 VAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-269 3.02e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 3.02e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070   8 GHSSSILCLNASKDG-LVASGGEGGDLVAWgEDGTPVGHMQLEG-ADDVTSIVFSASCPTKLYASHGESISVLDVRSLKg 85
Cdd:cd00200    49 GHTGPVRDVAASADGtYLASGSSDKTIRLW-DLETGECVRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK- 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070  86 CLDHFHVNEEEINCLSLNETESLLASADDSGAIKILDLEKKKVTRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWS 165
Cdd:cd00200   127 CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWD 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070 166 LQKARpvWITNLQEDEteetegpqtpgrllnpALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCERELgfKGHTLGVS 245
Cdd:cd00200   206 LSTGK--CLGTLRGHE----------------NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL--SGHTNSVT 265

                         250       260
                  ....*....|....*....|....
gi 2173616070 246 QVCFLPESHLLLTGGNDGKIRLWD 269
Cdd:cd00200   266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-270 7.59e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 7.59e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070   8 GHSSSILCLNASKDG-LVASGGEGGDLVAWG-EDG----TPVGHmqlegADDVTSIVFSAScpTKLYASHGE--SISVLD 79
Cdd:cd00200     7 GHTGGVTCVAFSPDGkLLATGSGDGTIKVWDlETGellrTLKGH-----TGPVRDVAASAD--GTYLASGSSdkTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070  80 VRSLKgCLDHFHVNEEEINCLSLNETESLLASADDSGAIKILDLEKKKVTRSLKRHSNICSSVAFRPQrPQSLVSCGLDM 159
Cdd:cd00200    80 LETGE-CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070 160 QVMLWSLQKARPVWItnlqedeteetegpqtpgrllnpALAHSISVASC-----GNIFSCGAEDGKVRIFRVMGVKCERE 234
Cdd:cd00200   158 TIKLWDLRTGKCVAT-----------------------LTGHTGEVNSVafspdGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2173616070 235 LgfKGHTLGVSQVCFLPESHLLLTGGNDGKIRLWDV 270
Cdd:cd00200   215 L--RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 44-278 6.14e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 6.14e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070  44 GHMqlegaDDVTSIVFSASCPTKLYASHGESISVLDVRSLKgCLDHFHVNEEEIN-CLSLNETESLLASADDsGAIKILD 122
Cdd:cd00200     7 GHT-----GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRdVAASADGTYLASGSSD-KTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070 123 LEKKKVTRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWSLQKARPVwiTNLQedeteeteGPQTPGRllnpalahS 202
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCL--TTLR--------GHTDWVN--------S 140

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2173616070 203 ISVASCGNIFSCGAEDGKVRIFRVMGVKCERElgFKGHTLGVSQVCFLPESHLLLTGGNDGKIRLWDVSGKMEKQQ 278
Cdd:cd00200   141 VAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT--LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214
WD40 COG2319
WD40 repeat [General function prediction only];
16-272 5.96e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 5.96e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070  16 LNASKDGLVASGGEGGDLVAWGEDGTPVGHMQLEGADDVTSIVFSAScPTKLYASHGESISVLDVRSLKGCLDHFHVNEE 95
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPD-GARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070  96 EINCLSLNETESLLASADDSGAIKILDLEKKKVTRSLKRHSNICSSVAFRPQRpQSLVSCGLDMQVMLWSLQKarpvwit 175
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLAT------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070 176 nlqedeteetegpqtpGRLLNPALAHSISVASC-----GNIFSCGAEDGKVRIFRVMGVKCERELgfKGHTLGVSQVCFL 250
Cdd:COG2319   152 ----------------GKLLRTLTGHSGAVTSVafspdGKLLASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFS 213

                         250       260
                  ....*....|....*....|..
gi 2173616070 251 PESHLLLTGGNDGKIRLWDVSG 272
Cdd:COG2319   214 PDGKLLASGSADGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 129-285 3.57e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.06  E-value: 3.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070 129 TRSLKRHSNICSSVAFRPQrPQSLVSCGLDMQVMLWSLQKarpvwitnlQEDETEETEGPQTPGRLLnpALAHSISVASC 208
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLET---------GELLRTLKGHTGPVRDVA--ASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2173616070 209 GNifscgaeDGKVRIFRVMGVKCERElgFKGHTLGVSQVCFLPESHLLLTGGNDGKIRLWDVSGKMEKQ----QKSPVKH 284
Cdd:cd00200    70 SS-------DKTIRLWDLETGECVRT--LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTtlrgHTDWVNS 140


                  .
gi 2173616070 285 I 285
Cdd:cd00200   141 V 141
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-269 8.53e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 8.53e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2173616070  237 FKGHTLGVSQVCFLPESHLLLTGGNDGKIRLWD 269
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
237-269 5.06e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 5.06e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2173616070 237 FKGHTLGVSQVCFLPESHLLLTGGNDGKIRLWD 269
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 125-165 3.49e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 3.49e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2173616070  125 KKKVTRSLKRHSNICSSVAFRPQRPQsLVSCGLDMQVMLWS 165
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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