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Conserved domains on  [gi|47078235|ref|NP_001486|]
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GDNF family receptor alpha-2 isoform a preproprotein [Homo sapiens]

Protein Classification

GDNF family receptor alpha( domain architecture ID 10658249)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF, the glial cell line-derived neurotrophic factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 251-347 1.39e-23

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 94.13  E-value: 1.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235   251 CLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPadNYQACLGSYagmigfDMTPNYVDSSPTgiVVSPWCSCRGSGN 330
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP--NPARCLRAY------RMTPNYVDNLGT--SLLLWCTCKGSGN 70

                          90
                  ....*....|....*..
gi 47078235   331 MEEECEKFLRDFTENPC 347
Cdd:pfam02351  71 QDEECEEFRRNFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 161-241 2.10e-18

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 79.88  E-value: 2.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235   161 CLDAAKACNLNDNCKKLRSSYISICNREISPTERC-NRRKCHKALRQFFDRVPSEYTYRMLFCSC-----QDQACAERRR 234
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCpNPARCLRAYRMTPNYVDNLGTSLLLWCTCkgsgnQDEECEEFRR 80


                  ....*..
gi 47078235   235 QTILPSC 241
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 40-113 1.05e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 49.56  E-value: 1.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235     40 CVRANELCAAESNCSSR-YRTLRQCLAGRDR-NTMLANKECQAALEVLQESPLYD--------CRCKRgmKKELQCLQIY 109
Cdd:smart00907   1 CLEALKACELDPVCRSRlADYLSACSPSPSSsCPGENSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEECLEFR 78


                   ....
gi 47078235    110 WSIH 113
Cdd:smart00907  79 RLFH 82
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 251-347 1.39e-23

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 94.13  E-value: 1.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235   251 CLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPadNYQACLGSYagmigfDMTPNYVDSSPTgiVVSPWCSCRGSGN 330
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP--NPARCLRAY------RMTPNYVDNLGT--SLLLWCTCKGSGN 70

                          90
                  ....*....|....*..
gi 47078235   331 MEEECEKFLRDFTENPC 347
Cdd:pfam02351  71 QDEECEEFRRNFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 161-241 2.10e-18

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 79.88  E-value: 2.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235   161 CLDAAKACNLNDNCKKLRSSYISICNREISPTERC-NRRKCHKALRQFFDRVPSEYTYRMLFCSC-----QDQACAERRR 234
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCpNPARCLRAYRMTPNYVDNLGTSLLLWCTCkgsgnQDEECEEFRR 80


                  ....*..
gi 47078235   235 QTILPSC 241
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 251-347 2.04e-17

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 76.91  E-value: 2.04e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235    251 CLDLRGVCRTDHLCRSRLADFHANCRASYQtvTSCPADNYQACLGSYAGMigfDMTPNYVDSSptgiVVSPWCSCRgsGN 330
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPS--SSCPGENSEACLRAYCGL---ALRPFYDDNS----SVLLFCTCA--GN 69

                           90
                   ....*....|....*..
gi 47078235    331 MEEECEKFLRDFTENPC 347
Cdd:smart00907  70 RDEECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 161-241 9.48e-16

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 72.29  E-value: 9.48e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235    161 CLDAAKACNLNDNCKKLRSSYISICNREISP------TERCNRRKCHKALRQFFDRvpseYTYRMLFCSCQ---DQACAE 231
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSscpgenSEACLRAYCGLALRPFYDD----NSSVLLFCTCAgnrDEECLE 76

                           90
                   ....*....|
gi 47078235    232 RRRQTILPSC 241
Cdd:smart00907  77 FRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 40-113 1.05e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 49.56  E-value: 1.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235     40 CVRANELCAAESNCSSR-YRTLRQCLAGRDR-NTMLANKECQAALEVLQESPLYD--------CRCKRgmKKELQCLQIY 109
Cdd:smart00907   1 CLEALKACELDPVCRSRlADYLSACSPSPSSsCPGENSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEECLEFR 78


                   ....
gi 47078235    110 WSIH 113
Cdd:smart00907  79 RLFH 82
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 40-113 2.85e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 48.30  E-value: 2.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235    40 CVRANELCAAESNCSSRYRT-LRQCLAGRDR-NTMLANKECQAALEVLQE-------SPLYDCRCKRGMKKELQCLQIYW 110
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADfQSNCQPSPEScSGCPNPARCLRAYRMTPNyvdnlgtSLLLWCTCKGSGNQDEECEEFRR 80


                  ...
gi 47078235   111 SIH 113
Cdd:pfam02351  81 NFT 83
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 251-347 1.39e-23

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 94.13  E-value: 1.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235   251 CLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPadNYQACLGSYagmigfDMTPNYVDSSPTgiVVSPWCSCRGSGN 330
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP--NPARCLRAY------RMTPNYVDNLGT--SLLLWCTCKGSGN 70

                          90
                  ....*....|....*..
gi 47078235   331 MEEECEKFLRDFTENPC 347
Cdd:pfam02351  71 QDEECEEFRRNFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 161-241 2.10e-18

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 79.88  E-value: 2.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235   161 CLDAAKACNLNDNCKKLRSSYISICNREISPTERC-NRRKCHKALRQFFDRVPSEYTYRMLFCSC-----QDQACAERRR 234
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCpNPARCLRAYRMTPNYVDNLGTSLLLWCTCkgsgnQDEECEEFRR 80


                  ....*..
gi 47078235   235 QTILPSC 241
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 251-347 2.04e-17

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 76.91  E-value: 2.04e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235    251 CLDLRGVCRTDHLCRSRLADFHANCRASYQtvTSCPADNYQACLGSYAGMigfDMTPNYVDSSptgiVVSPWCSCRgsGN 330
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPS--SSCPGENSEACLRAYCGL---ALRPFYDDNS----SVLLFCTCA--GN 69

                           90
                   ....*....|....*..
gi 47078235    331 MEEECEKFLRDFTENPC 347
Cdd:smart00907  70 RDEECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 161-241 9.48e-16

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 72.29  E-value: 9.48e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235    161 CLDAAKACNLNDNCKKLRSSYISICNREISP------TERCNRRKCHKALRQFFDRvpseYTYRMLFCSCQ---DQACAE 231
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSscpgenSEACLRAYCGLALRPFYDD----NSSVLLFCTCAgnrDEECLE 76

                           90
                   ....*....|
gi 47078235    232 RRRQTILPSC 241
Cdd:smart00907  77 FRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 40-113 1.05e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 49.56  E-value: 1.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235     40 CVRANELCAAESNCSSR-YRTLRQCLAGRDR-NTMLANKECQAALEVLQESPLYD--------CRCKRgmKKELQCLQIY 109
Cdd:smart00907   1 CLEALKACELDPVCRSRlADYLSACSPSPSSsCPGENSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEECLEFR 78


                   ....
gi 47078235    110 WSIH 113
Cdd:smart00907  79 RLFH 82
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 40-113 2.85e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 48.30  E-value: 2.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47078235    40 CVRANELCAAESNCSSRYRT-LRQCLAGRDR-NTMLANKECQAALEVLQE-------SPLYDCRCKRGMKKELQCLQIYW 110
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADfQSNCQPSPEScSGCPNPARCLRAYRMTPNyvdnlgtSLLLWCTCKGSGNQDEECEEFRR 80


                  ...
gi 47078235   111 SIH 113
Cdd:pfam02351  81 NFT 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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