NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4504683|ref|NP_001548|]
View 

C-X-C chemokine receptor type 2 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606911)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
49-325 3.48e-148

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


:

Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 419.37  E-value: 3.48e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15178   1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVKGWIFGTFMCKLVSLLQEA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVS-PACYEDMGNNTAN- 206
Cdd:cd15178  81 NFYSGILLLACISVDRYLAIVHATRALTQKRHLVKFVCAGVWLLSLLLSLPALLNRDAFKPPNSGrTVCYENLGNESADk 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETC 286
Cdd:cd15178 161 WRVVLRILRHTLGFLLPLVVMLFCYGFTIKTLLQTRSFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMRTKLITETC 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4504683  287 ERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15178 241 ELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
 
Name Accession Description Interval E-value
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
49-325 3.48e-148

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 419.37  E-value: 3.48e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15178   1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVKGWIFGTFMCKLVSLLQEA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVS-PACYEDMGNNTAN- 206
Cdd:cd15178  81 NFYSGILLLACISVDRYLAIVHATRALTQKRHLVKFVCAGVWLLSLLLSLPALLNRDAFKPPNSGrTVCYENLGNESADk 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETC 286
Cdd:cd15178 161 WRVVLRILRHTLGFLLPLVVMLFCYGFTIKTLLQTRSFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMRTKLITETC 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4504683  287 ERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15178 241 ELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
65-314 1.73e-48

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 164.01  E-value: 1.73e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683     65 GNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFYSGILLLACIS 141
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVAdLLFSLLTLPFWLVYYLNHgdWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683    142 VDRYLAIVHATRTLT-QKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVS-PACYEDMGNNTANWRmLLRILPQSFG 219
Cdd:pfam00001  81 IDRYLAIVHPLRYKRrRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNvTVCFIDFPEDLSKPV-SYTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683    220 FIVPLLIMLFCYGFTLRTLFKAHM--------GQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRtqviqeTCERRNH 291
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASkqkssertQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLAL------DCELSRL 233
                         250       260
                  ....*....|....*....|...
gi 4504683    292 IDRALDATEILGILHSCLNPLIY 314
Cdd:pfam00001 234 LDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
23-321 2.03e-41

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 148.00  E-value: 2.03e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683    23 YSYSSTLPPFLLDAAPCEPESL-EINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVgRSVTDVYLLNLALADLLFALTL 101
Cdd:PHA03087  14 TTDYYYDTYYDEDYADCDLNIGyDTNSTILIVVYSTIFFFGLVGNIIVIYVLTKTKI-KTPMDIYLLNLAVSDLLFVMTL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   102 PIWAA-SKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWgLSLLLALP 179
Cdd:PHA03087  93 PFQIYyYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYgYIVSLVIW-IISIIETT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   180 VLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQK-HRAMRVIFAVVL 258
Cdd:PHA03087 172 PILFVYTTKKDHETLICCMFYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKILITLKGINKSKKnKKAIKLVLIIVI 251
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504683   259 IFLLCWLPYNLVLLAdTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKF 321
Cdd:PHA03087 252 LFVIFWLPFNVSVFV-YSLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFF 313
 
Name Accession Description Interval E-value
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
49-325 3.48e-148

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 419.37  E-value: 3.48e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15178   1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVKGWIFGTFMCKLVSLLQEA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVS-PACYEDMGNNTAN- 206
Cdd:cd15178  81 NFYSGILLLACISVDRYLAIVHATRALTQKRHLVKFVCAGVWLLSLLLSLPALLNRDAFKPPNSGrTVCYENLGNESADk 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETC 286
Cdd:cd15178 161 WRVVLRILRHTLGFLLPLVVMLFCYGFTIKTLLQTRSFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMRTKLITETC 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4504683  287 ERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15178 241 ELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
49-325 1.97e-104

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 308.37  E-value: 1.97e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd14984   1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAADGWVFGSFLCKLVSALYTI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTL-TQKRYLVKFICLSIWGLSLLLALPVLLFRrTVYSSNVSPACYEDMGNNTAN- 206
Cdd:cd14984  81 NFYSGILFLACISIDRYLAIVHAVSALrARTLLHGKLTCLGVWALALLLSLPEFIFS-QVSEENGSSICSYDYPEDTATt 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETC 286
Cdd:cd14984 160 WKTLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRARNHKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQLLGIISRSC 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4504683  287 ERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14984 240 ELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
50-322 9.32e-81

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 248.07  E-value: 9.32e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15180   2 FLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHGWIFGTGLCKLAGAVFKIN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTLTQKR-YLVKFICLSIWGLSLLLALPVLLFRRTVYSSN-VSPACYEDMGNNTANW 207
Cdd:cd15180  82 FYCGIFLLACISFDRYLSIVHAVQMYSRKKpMLVHLSCLIVWLFCLLLSIPDFIFLEATKDPRqNKTECVHNFPQSDTYW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMG-QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETC 286
Cdd:cd15180 162 WLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRSSQGfQKQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVLDRNC 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4504683  287 ERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15180 242 GTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFR 277
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
50-325 5.34e-68

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 215.38  E-value: 5.34e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15181   2 FIPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAGWVFGTFLCKLVGAIHKLN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTLTQKRYL-VKFICLSIWGLSLLLALPVLLFRR--TVYSSNVSPACYEDMGNNTAN 206
Cdd:cd15181  82 FYCSSLLLACISVDRYLAIVHAIHSYRHRRLRsVHLTCGSIWLVCFLLSLPNLVFLEveTSTNANRTSCSFHQYGIHESN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMG-QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQET 285
Cdd:cd15181 162 WWLTSRFLYHVVGFFLPLLIMGYCYATIVVTLCQSSRRlQKQKAIRVAILVTLVFCLCWLPYNIVIFLDTLDDLKAVVKN 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4504683  286 CERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15181 242 CKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
50-322 8.34e-66

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 209.61  E-value: 8.34e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15172   2 FVPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYEAHQWIFGNFSCKLLRGIYAIN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATR-------TLTQKRYlvkfICLSIWGLSLLLALPVLLF-RRTVYSSNVSPACYE--D 199
Cdd:cd15172  82 FYSGMLLLACISVDRYIAIVQATKsfrlrsrTLAYSKL----ICAAVWLLAILISLPTFIFsEVYDFGLEEQYVCEPkyP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  200 MGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRT 279
Cdd:cd15172 158 KNSTAIMWKLLVLSLQVSLGFFIPLLVMIFCYSFIIKTLLQAQNSQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEAINLG 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  280 QviQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15172 238 E--QQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFR 278
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
49-325 2.47e-63

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 203.44  E-value: 2.47e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15174   1 YFLPPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAASSGWVFGTFLCKVVNSMYKI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATR--TLTQKRYLV-KFICLSIWGLSLLLALPVLLFRRT--VYSSNVSPACYEDMGNN 203
Cdd:cd15174  81 NFYSCMLLLTCISVDRYIAIVQATKahNSKNKRLLYsKLVCFFVWLLSTILSLPEILFSQSkeEESVTTCTMVYPSNESN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  204 taNWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQ 283
Cdd:cd15174 161 --RFKVAVLALKVTVGFFLPFVVMVICYTLIIHTLLQAKRFQKHKALKVIIAVVTVFVLSQLPYNSILLIKTINAYNITI 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  284 ETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15174 239 TDCATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKDL 280
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
50-322 3.30e-60

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 194.99  E-value: 3.30e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15179   2 FLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAANWYFGNFLCKAVHVIYTVN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWGLSLLLALPVLLFRRtVYSSNVSPACYEDMGNNT-ANW 207
Cdd:cd15179  82 LYSSVLILAFISLDRYLAIVHATNSQRPRKLLAeKVVYVGVWLPALLLTVPDLVFAK-VSELDDRYICDRIYPEDTfELW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCE 287
Cdd:cd15179 161 VVAFRFQHILVGLVLPGLVILTCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDTFMLLEIIKQSCE 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 4504683  288 RRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15179 241 MEQTVHKWISITEALAFFHCCLNPILYAFLGAKFK 275
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
50-325 1.78e-58

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 190.75  E-value: 1.78e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15175   2 FLPAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASAAKKWVFGEEMCKAVYCLYKMS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHAT---RTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVsPACyEDMGNNTAN 206
Cdd:cd15175  82 FFSGMLLLMCISIDRYFAIVQAAsahRHRSRAVFISKVSSLGVWVLAFILSIPELLYSGVNNNDGN-GTC-SIFTNNKQT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETC 286
Cdd:cd15175 160 LSVKIQISQMVLGFLVPLVVMSFCYSVIIKTLLQARNFEKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFKGNTTDC 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4504683  287 ERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15175 240 DYSKNLDFALDVTYSLACFRCCLNPFLYAFIGVKFRNDL 278
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
49-322 1.05e-56

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 186.10  E-value: 1.05e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15176   1 LFLPVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAVNGWVLGTAMCKITSALYTM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKfICLSIWGLSLLLALPVLLFrRTVYSSNVSPACY----EDMGNNT 204
Cdd:cd15176  81 NFSCGMQFLACISVDRYVAITKATSRQFTGKHCWI-VCLCVWLLAILLSIPDLVF-STVRENSDRYRCLpvfpPSLVTSA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 anwRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQE 284
Cdd:cd15176 159 ---KATIQILEVLLGFVLPFLVMVFCYSRVARALSRTPNVKKSRALKVLLAVVGVFIVTQLPYNVVKFYRAIDVIYLLIT 235
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4504683  285 TCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15176 236 DCSMSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
50-322 1.64e-52

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 174.86  E-value: 1.64e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15182   2 FLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYHSSGWIFGEILCKAVTSIFYIG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTL-TQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDmgnntaNWR 208
Cdd:cd15182  82 FYSSILFLTLMTIDRYLAVVHPLSALrSRKLRYASLVSVAVWVISILASLPELILSTVMKSDEDGSLCEYS------SIK 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  209 MLLRILPQSFG-FIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQetCE 287
Cdd:cd15182 156 WKLGYYYQQNLfFLIPLGIIVYCYVRILQTLMRTRTMRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSLKDLTIPI--CE 233
                       250       260       270
                ....*....|....*....|....*....|....*
gi 4504683  288 RRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15182 234 CSKQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFR 268
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
50-325 2.32e-52

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 174.97  E-value: 2.32e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLV-ILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15188   2 FLPVFYTLVFLLGLAGNLLLFVVlLLYVPKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVAWHWVFGSFLCKFVSTLYTI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHAT---RTLTQKRYLVkfICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTA 205
Cdd:cd15188  82 NFYSGIFFVSCMSLDKYLEIVHAQsphRLRTRRKSLL--VLVAVWVLSIALSVPDMVFVQTHHTNNGVWVCHADYGGHHT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQeT 285
Cdd:cd15188 160 IWKLVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRPPGQGRALRFVAALVVVFFVLWFPYNLTLFLHSLQDLHVIG-N 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4504683  286 CERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15188 239 CERSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFRLYL 278
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
54-322 9.77e-52

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 173.42  E-value: 9.77e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSG 133
Cdd:cd15177   6 VYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETLQGWIFGNAMCKLIQGLYAINFYSG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  134 ILLLACISVDRYLAIVHAT---RTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSpAC---YEDMGNNTAnw 207
Cdd:cd15177  86 FLFLTCISVDRYVVIVRATsahRLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELS-SCrmiFPEVVSRTV-- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCE 287
Cdd:cd15177 163 KGATALTQVVLGFAIPLIVMAVCYAAIGRTLLAARGWERHRALRVIAALVVAFVLFQLPYSVVLLLDTADLLATLELSCS 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 4504683  288 RRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15177 243 QSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFR 277
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
49-323 2.90e-49

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 167.06  E-value: 2.90e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAA--SKVNGWIFGTFLCKVVSLLK 126
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYyyLNGGWWPFGDFLCRLTGLLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHA--TRTLTQKRYLVKfICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNT 204
Cdd:cd14982  81 YINMYGSILFLTCISVDRYLAVVHPlkSRRLRRKRYAVG-VCAGVWILVLVASVPLLLLRSTIAKENNSTTCFEFLSEWL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWrMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK-----AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRT 279
Cdd:cd14982 160 ASA-APIVLIALVVGFLIPLLIILVCYSLIIRALRRrskqsQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVRL 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4504683  280 QVIQEtCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd14982 239 SFIAD-CSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRK 281
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
65-314 1.73e-48

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 164.01  E-value: 1.73e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683     65 GNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFYSGILLLACIS 141
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVAdLLFSLLTLPFWLVYYLNHgdWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683    142 VDRYLAIVHATRTLT-QKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVS-PACYEDMGNNTANWRmLLRILPQSFG 219
Cdd:pfam00001  81 IDRYLAIVHPLRYKRrRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNvTVCFIDFPEDLSKPV-SYTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683    220 FIVPLLIMLFCYGFTLRTLFKAHM--------GQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRtqviqeTCERRNH 291
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASkqkssertQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLAL------DCELSRL 233
                         250       260
                  ....*....|....*....|...
gi 4504683    292 IDRALDATEILGILHSCLNPLIY 314
Cdd:pfam00001 234 LDKALSVTLWLAYVNSCLNPIIY 256
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
50-322 2.26e-48

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 164.47  E-value: 2.26e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd14985   2 VIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQydWPFGAFLCKVSSYVIS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWGLSLLLALPVLLFR--RTVYSSNVsPACYEDMgnNT 204
Cdd:cd14985  82 VNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQaRVTCALIWVVACLLSLPTFLLRslQAIENLNK-TACIMLY--PH 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKH------RAMRVIFAVVLIFLLCWLPYNLVLLADTLMR 278
Cdd:cd14985 159 EAWHFGLSLELNILGFVLPLLIILTCYFHIARSLRKRYERTGKngrkrrKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQ 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4504683  279 TQVIQEtCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd14985 239 LGAIRP-CFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFR 281
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
49-322 2.38e-48

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 164.17  E-value: 2.38e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15173   1 YFLPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAAHEWIFGTVMCKITNGLYTI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQ---KRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVspacYEDMGNNTA 205
Cdd:cd15173  81 NLYSSMLILTCITVDRFIVIVQATKAHNChakKMRWGKVVCTLVWVISLLLSLPQFIYSEVRNLSSK----ICSMVYPPD 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLladtLMRTQVIQET 285
Cdd:cd15173 157 AIEVVVNIIQMTVGFFLPLLAMIICYSVIIKTLLHAKGFQKHKSLKIIFVVVAVFILTQLPYNIMK----LIRTLHIENT 232
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4504683  286 CErrNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15173 233 DS--TNFKYAILITEAIAYLHACLNPILYAFVGVKFR 267
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
50-325 5.85e-48

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 163.43  E-value: 5.85e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15187   2 FLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLLDQWVFGNAMCKIVSGAYYIG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWGLSLLLALPVLLFRRTVYSSNVSpACYEDMGNNTANWR 208
Cdd:cd15187  82 FYSSMFFITLMSIDRYLAIVHAVYALKVRTASHgTILSLALWLVAILASVPLLVFYQVASEDGRL-QCIPFYPGQGNSWK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  209 MLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLmRTQVIQETCER 288
Cdd:cd15187 161 VFTNFEVNILGLLIPFSILIFCYHNILRNLRRCHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSL-HSLHIIDGCQN 239
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4504683  289 RNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15187 240 SQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKKHL 276
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
54-322 6.31e-48

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 163.39  E-value: 6.31e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSG 133
Cdd:cd15184   6 LYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNAMCKLLTGLYHIGFFSG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  134 ILLLACISVDRYLAIVHATRTLtQKRYLVKFICLSI--WGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLL 211
Cdd:cd15184  86 IFFIILLTIDRYLAIVHAVFAL-KARTVTFGVVTSVvtWVVAVFASLPGIIFTKSQKEGSHYTCSPHFPPSQYQFWKNFQ 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  212 RILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQK-HRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIqETCERRN 290
Cdd:cd15184 165 TLKMNILGLVLPLLVMIICYSGILKTLLRCRNEKKrHKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGL-NNCSSSN 243
                       250       260       270
                ....*....|....*....|....*....|..
gi 4504683  291 HIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15184 244 RLDQAMQVTETLGMTHCCINPVIYAFVGEKFR 275
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
50-325 2.22e-45

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 156.53  E-value: 2.22e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15186   2 FLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLINEWGLHNAMCKLTTAFFFIG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTLTQKRYLVKF-ICLSIWGLSLLLALPVLLFRRTVYSSnvspaCYEDMGNNTAN-W 207
Cdd:cd15186  82 FFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVtISLGVWAAAILVAVPQFMFTKMKENE-----CLGDYPEVLQEiW 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLmRTQVIQETCE 287
Cdd:cd15186 157 PVLRNVELNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETL-KLYDFFPSCD 235
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4504683  288 RRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15186 236 MKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFRRYL 273
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
51-322 9.56e-44

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 152.59  E-value: 9.56e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEV 128
Cdd:cd15192   3 IPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEyhWPFGNFLCKIASALVSF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWGLSLLLALPVLLFRRTVYSSNVS-PACYEDMGNNTAN 206
Cdd:cd15192  83 NLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVaRVTCIVIWLLAGVASLPAIIHRDVFFIENTNiTVCAFHYPSQNST 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHR-----AMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQV 281
Cdd:cd15192 163 LLVGLGLMKNLLGFLIPFLIILTCYTLIGKALKKAYEIQRNKprndeIFKMIMAVVLFFFFCWIPHQIFTFLDVLIQLKV 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4504683  282 IQEtCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15192 243 IQD-CHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFR 282
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
23-321 2.03e-41

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 148.00  E-value: 2.03e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683    23 YSYSSTLPPFLLDAAPCEPESL-EINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVgRSVTDVYLLNLALADLLFALTL 101
Cdd:PHA03087  14 TTDYYYDTYYDEDYADCDLNIGyDTNSTILIVVYSTIFFFGLVGNIIVIYVLTKTKI-KTPMDIYLLNLAVSDLLFVMTL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   102 PIWAA-SKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWgLSLLLALP 179
Cdd:PHA03087  93 PFQIYyYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYgYIVSLVIW-IISIIETT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   180 VLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQK-HRAMRVIFAVVL 258
Cdd:PHA03087 172 PILFVYTTKKDHETLICCMFYNNKTMNWKLFINFEINIIGMLIPLTILLYCYSKILITLKGINKSKKnKKAIKLVLIIVI 251
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504683   259 IFLLCWLPYNLVLLAdTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKF 321
Cdd:PHA03087 252 LFVIFWLPFNVSVFV-YSLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFF 313
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
50-325 5.52e-41

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 144.97  E-value: 5.52e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAA-SKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15185   2 FLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHyVRWNNWVFGHGMCKLLSGFYYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSI-WGLSLLLALPVLLFRRTVYSSNV---SPACYEDmgnNT 204
Cdd:cd15185  82 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIItWGLAVLAALPEFIFYETQELFEEflcSPLYPED---TE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLmRTQVIQE 284
Cdd:cd15185 159 DSWKRFHALRMNIFGLALPLLIMVICYTGIIKTLLRCPSKKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAF-QSIFFET 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4504683  285 TCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15185 238 DCERSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-322 8.88e-40

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 142.22  E-value: 8.88e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   58 VFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVN--GWIFGTFLCKVVSLLKEVNFYSGIL 135
Cdd:cd15189  10 LCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNqfNWPFGELLCRVVNGVIKVNLYTSIY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  136 LLACISVDRYLAIVH--ATRTLTQKRYlVKFICLSIWGLSLLLALPVLLFRRTV-YSSNVSPACYEDMGNntANWRMLLR 212
Cdd:cd15189  90 LLVMISQDRYLALVKtmAARRLRRRRY-AKLICVLIWVVGLLLSIPTFLLRKIKaIPDLNITACVLLYPH--EAWHFAHI 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  213 ILPQSFGFIVPLLIMLFCYGFTLRTLFKAHM------GQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQEtC 286
Cdd:cd15189 167 VLLNIVGFLLPLLVITFCNYNILQALRTREEstrcedRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLFDVGVLDE-C 245
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4504683  287 ERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15189 246 FWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFR 281
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
50-325 2.22e-39

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 141.04  E-value: 2.22e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15191   2 AIPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGynWLFGSVMCKICGSLLT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVS-PACYEDMGNNT-A 205
Cdd:cd15191  82 LNLFASIFFITCMSVDRYLAVVYPLRSQRRRSWQARLVCLLVWVLACLSSLPTFYFRDTYYIEELGvNACIMAFPNEKyA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKA-----HMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQ 280
Cdd:cd15191 162 QWSAGLALMKNTLGFLIPLIVIATCYFGIGRHLLKTkgfgkNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDALARMG 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4504683  281 VIqETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15191 242 VI-NNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
49-325 6.71e-39

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 139.89  E-value: 6.71e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV--NGWIFGTFLCKVVSLLK 126
Cdd:cd14987   1 YTLSFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVqhNQWPMGEFTCKITHLIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWGLSLLLALPVLLFRRTVYS-SNVSPACYEDMG-NN 203
Cdd:cd14987  81 SINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVrRIICVLVWLLAFVASLPDTYFLKTVTSpSNNETYCRSFYPeES 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  204 TANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQ 283
Cdd:cd14987 161 FKEWLIGMELVSIVLGFVIPFPIIAVFYFLLARAISASSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDILSFLHLIP 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  284 ETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14987 241 FSCQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYRYEL 282
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-322 1.62e-38

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 139.51  E-value: 1.62e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   39 CEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRV-GRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFG 115
Cdd:cd15190   1 CDYTEWKPSYALIPVIYMLVFVLGLSGNGLVLWTVFRSKRkRRRSADTFIANLALADLTFVVTLPLWAVYTALGyhWPFG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  116 TFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHA-TRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTV-YSSNVS 193
Cdd:cd15190  81 SFLCKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSlASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSdLEGTNK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  194 PACYEDMGNNTAN-----WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTL-------FKAHMGQKHRAMRVIFAVVLIFL 261
Cdd:cd15190 161 VICDMDYSGVVSNesewaWIAGLGLSSTVLGFLLPFLIMLTCYFFIGRTVarhfsklRRKEDKKKRRLLKIIITLVVTFA 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504683  262 LCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15190 241 LCWLPFHLVKTLYALMYLGILPFSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFR 301
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
57-322 1.84e-38

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 138.75  E-value: 1.84e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   57 LVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFYSGI 134
Cdd:cd15381   9 IIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGfnWPFGEFLCKSVNAVIYMNLYSSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  135 LLLACISVDRYLAIVHaTRTLTQKR--YLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVS-PACYEDMGNntANWRMLL 211
Cdd:cd15381  89 YFLMMVSIDRYLALVK-TMSSGRMRrpACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNiTACVLDYPS--EGWHVAL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  212 RILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQ------KHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIqET 285
Cdd:cd15381 166 NILLNVVGFLIPLSIITFCSTQIIQVLRNNKMQKfkeiqtERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKLGLI-SG 244
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4504683  286 CERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15381 245 CRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFR 281
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
54-322 2.86e-38

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 138.08  E-value: 2.86e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVNFYS 132
Cdd:cd15183   6 LYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDdWIFGDAMCKFLSGFYYLGLYS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  133 GILLLACISVDRYLAIVHATRTLTQKRYLVKFI-CLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLL 211
Cdd:cd15183  86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIItSIITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKSLIRWKRFQ 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  212 RILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLAdTLMRTQVIQETCERRNH 291
Cdd:cd15183 166 ALKLNLLGLILPLLVMIICYTGIINILLRRPNEKKAKAVRLIFVITLLFFLLWTPYNLAAFV-SAFQDVLFTPSCEQSQQ 244
                       250       260       270
                ....*....|....*....|....*....|.
gi 4504683  292 IDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15183 245 LDLALQVTEVIAYTHCCVNPVIYVFVGERFR 275
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
50-323 1.80e-37

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 136.03  E-value: 1.80e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15193   2 YIPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGgqWLFGEGLCKLSSFIIA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIV--HATRTLTQKRYLVKfICLSIWGLSLLLALPVLLFRRTVYSSnvspACYEDMGNNTA 205
Cdd:cd15193  82 VNRCSSILFLTGMSVDRYLAVVklLDSRPLRTRRCALI-TCCIIWAVSLVLGIPSLVYRNLINES----VCVEDSSSRFF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILpqsFGFIVPLLIMLFCYGFTLRTLFK-----AHMGQK-HRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRT 279
Cdd:cd15193 157 QGISLATLF---LTFVLPLIVILFCYCSILVRLRRhfhgaKRTGRRrRNSLRIVFAIVTAFVLSWLPFNTLKAVRLLLEL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4504683  280 QVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15193 234 GGGVLPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
50-322 2.21e-37

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 135.89  E-value: 2.21e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVIL-YSRVgRSVTDVYLLNLALADLLFALTLPIWAAS-KVNGWIFGTFLCKVVSLLKE 127
Cdd:cd14970   2 VIPAVYSVVCVVGLTGNSLVIYVILrYSKM-KTVTNIYILNLAVADELFLLGLPFLATSyLLGYWPFGEVMCKIVLSVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTAN 206
Cdd:cd14970  81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKaKLVSLCVWALSLVLGLPVIIFARTLQEEGGTISCNLQWPDPPDY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTL------FKAHMGQKHRAM----RVIFAVVLIFLLCWLPY---NLVLLA 273
Cdd:cd14970 161 WGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLrssrnlSTSGAREKRRARrkvtRLVLVVVAVFVVCWLPFhvfQIVRLL 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4504683  274 DTLMRTQVIQETcerrnhidraLDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd14970 241 IDPPETLTVVGV----------FLFCIALSYANSCLNPILYAFLDENFR 279
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
52-322 2.26e-35

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 130.11  E-value: 2.26e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVmLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVN 129
Cdd:cd14974   4 LVLYALIFLLGLPGNGLV-IWVAGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGhhWPFGSVLCKLNSFVISLN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTLTQKR-YLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYE-----DMGNN 203
Cdd:cd14974  83 MFASVFLLTAISLDRCLLVLHPVWAQNHRTvRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTcvedyDLRRS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  204 TANWRMLLRILpqsFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLmrtqviq 283
Cdd:cd14974 163 RHKALTVIRFL---CGFLLPLLIIAICYSVIAVKLRRKRLAKSSKPLRVLLAVVVAFFLCWLPYHVFALLELV------- 232
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4504683  284 ETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd14974 233 AAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFR 271
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
49-322 4.30e-35

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 130.79  E-value: 4.30e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683    49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVgRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:PHA02834  29 YFVIVFYILLFIFGLIGNVLVIAVLIVKRF-MFVVDVYLFNIAMSDLMLVFSFPFIIHNDLNEWIFGEFMCKLVLGVYFV 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTAnWR 208
Cdd:PHA02834 108 GFFSNMFFVTLISIDRYILVVNATKIKNKSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQCIFNDYHENFS-WS 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   209 MLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCER 288
Cdd:PHA02834 187 AFFNFEINIFGIVIPLIILIYCYSKILYTLKNCKNKNKTRSIKIILTVVTFTVVFWVPFNIVLFINSLQSVGLIDIGCYH 266
                        250       260       270
                 ....*....|....*....|....*....|....
gi 4504683   289 RNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:PHA02834 267 FKKIVYSIDIAELISFVHCCVNPIIYAFVGKNFK 300
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
52-316 2.13e-34

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 127.79  E-value: 2.13e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVN 129
Cdd:cd00637   2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVAdLLVGLLVIPFSLVSLLLGrWWFGDALCKLLGFLQSVS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATR-TLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWR 208
Cdd:cd00637  82 LLASILTLTAISVDRYLAIVHPLRyRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKAY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  209 MLLRILpqsFGFIVPLLIMLFCYGFTLRTLFK---------------AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLA 273
Cdd:cd00637 162 TIFLFV---LLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrrRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLL 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  274 DTLMRTQViqetcerrNHIDRALDATEILGILHSCLNPLIYAF 316
Cdd:cd00637 239 DVFGPDPS--------PLPRILYFLALLLAYLNSAINPIIYAF 273
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
49-322 1.12e-33

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 125.89  E-value: 1.12e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLK 126
Cdd:cd15168   1 IFLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGdhWIFGDFMCKLVRFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLT-QKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSpACYEDMGNNTA 205
Cdd:cd15168  81 YFNLYGSILFLTCISVHRYLGICHPLRSLGkLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRT-TCYDTTSPEEL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK-----AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQ 280
Cdd:cd15168 160 NDYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRklgegVTSALRRKSIRLVIIVLALFAVCFLPFHVTRTINLAARLL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  281 VIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15168 240 SGTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFR 281
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
49-325 8.37e-33

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 123.86  E-value: 8.37e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLK 126
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVAdLLVSLFCMPLTLLENVyRPWVFGEVLCKAVPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVH---ATRTLTQKRylVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPA------CY 197
Cdd:cd14993  81 GVSVSASVLTLVAISIDRYLAICYplkARRVSTKRR--ARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPGtitiyiCT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  198 EDMGnnTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKA----------------HMGQKHRAMRVIFAVVLIFL 261
Cdd:cd14993 159 EDWP--SPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRkppgdrgsanstssrrILRSKKKVARMLIVVVVLFA 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504683  262 LCWLPYNLVllaDTLMRTQvIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14993 237 LSWLPYYVL---SILLDFG-PLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
61-322 5.35e-32

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 121.44  E-value: 5.35e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   61 LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVN--GWIFGTFLCKVVSLLKEVNFYSGILLLA 138
Cdd:cd15380  13 FGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNqfNWPFGNFLCRVISGVIKANLFISIFLVV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  139 CISVDRYLAIVHA-TRTLTQKRYLVKFICLSIWGLSLLLALPVLLFR--RTVYSSNVSpACYEDMgnNTANWRMLLRILP 215
Cdd:cd15380  93 AISQDRYRTLVHTmTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRsvKHVPDLNIS-ACILLF--PHEAWHFARRVEL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  216 QSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHR--------AMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQEtCE 287
Cdd:cd15380 170 NIVGFLLPLAAIVFFNFHIIASLRERTEESRKRcgglkdtkATRLILTLVLMFLVCWTPYHFFAFLDFLFQVEVIQG-CF 248
                       250       260       270
                ....*....|....*....|....*....|....*
gi 4504683  288 RRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15380 249 WEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
50-329 9.49e-32

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 123.58  E-value: 9.49e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683    50 FVVIIYALVFLLSLLGNSLVMLVILYSRVgRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN 129
Cdd:PHA02638 100 YIKIFYIIIFILGLFGNAAIIMILFCKKI-KTITDIYIFNLAISDLIFVIDFPFIIYNEFDQWIFGDFMCKVISASYYIG 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   130 FYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFI-CLSIWGLSLLLALPVLLF---RRTVYSSNVSP------ACYED 199
Cdd:PHA02638 179 FFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIIlCIISWILSLIITSPAYFIfeaSNIIFSAQDSNetisnyQCTLI 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   200 MGNNTANWRMLLRILP---QSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:PHA02638 259 EDNEKNNISFLGRILQfeiNILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKSIIIVSIIIICSLICWIPLNIVILFATM 338
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504683   277 MRTQ----VIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKIL 329
Cdd:PHA02638 339 YSFKgfnsIISEHICGFIKLGYAMMLAEAISLTHCCINPLIYTLIGENFRMHLLMIF 395
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
50-322 1.30e-31

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 120.25  E-value: 1.30e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYsRVGRSVTDVYLLNLALADLLFALTLPI---WAASKVNgWIFGTFLCKVVSLLK 126
Cdd:cd15116   2 LSMVIYSVVFVLGVLGNGLVIFITGF-KMKKTVNTVWFLNLAVADFLFTFFLPFsiaYTAMDFH-WPFGRFMCKLNSFLL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLTQKRY-LVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSP-ACYED---MG 201
Cdd:cd15116  80 FLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVrLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKiICFNNfslSG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  202 NNTANWRMLLRILPQS--------FGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLA 273
Cdd:cd15116 160 DNSSPEVNQLRNMRHQvmtitrflLGFLIPFTIIICCYAAIVLKLKRNRLAKSSKPFKIIAAVIVTFFLCWAPYHILNLL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4504683  274 DtLMRTQVIQETcerrnhIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15116 240 E-MEATRSPASV------FKIGLPITSSLAFINSCLNPILYVFMGQDFK 281
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
53-324 4.15e-31

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 119.10  E-value: 4.15e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAAS-KVNGWIFGTFLCKVVSLLKEVNFY 131
Cdd:cd15093   5 CIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASnALRHWPFGSVLCRLVLSVDGINMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  132 SGILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRML 210
Cdd:cd15093  85 TSIFCLTVMSVDRYLAVVHPIKSARWRRPRVaKVVNLAVWVASLLVILPVVVFAGTRENQDGSSACNMQWPEPAAAWSAG 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  211 LRILPQSFGFIVPLLIMLFCYGFTLRTL----FKAHMGQKHRA----MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVI 282
Cdd:cd15093 165 FIIYTFVLGFLLPLLIICLCYLLIVIKVksagLRAGWQQRKRSerkvTRMVVMVVVVFVICWLPFYVLQLVNVFVQLPET 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  283 QEtcerrnhIDRALDATEILGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd15093 245 PA-------LVGVYHFVVILSYANSCANPILYGFLSDNFKKS 279
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
51-325 1.45e-30

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 117.60  E-value: 1.45e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLViLYSRVGR---SVTDVYLLNLALADLLFALTLPIWAASKV--NGWIFGTFLCKVVSLL 125
Cdd:cd14976   3 VSVVYMVVFTVGLLGNLLVLYL-LKSNKKLrqqSESNKFVFNLALTDLIFVLTLPFWAVEYAldFVWPFGTAMCKVVRYV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  126 KEVNFYSGILLLACISVDRYLAIVHATRTL-TQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACY-----ED 199
Cdd:cd14976  82 TKLNMYSSIFFLTALSVTRYIAVARALKHGwIRKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSVNHTLCLlrfpkNS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  200 MGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRV---IFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd14976 162 SVTRWYNWLGMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSKRRKSRVtksVFIVVLSFFICWLPNQALSLWSAL 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4504683  277 MRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14976 242 IKFDDVPFSDAFFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
55-325 2.01e-30

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 117.12  E-value: 2.01e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   55 YALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFYS 132
Cdd:cd15161   7 YILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGnhWPFGEVPCRLAGFLFYLNMYA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  133 GILLLACISVDRYLAIVHATRTLTQKRYL-VKFICLSIWGLSLLLALPVLLFRRTVyssnvspacyedMGNNTANWRMLL 211
Cdd:cd15161  87 SLYFLACISVDRFLAIVHPVKSMKIRKPLyAHVVCGFLWVIVTVAMAPLLVSPQTV------------EVNNTTVCLQLY 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  212 R-------ILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKH---RAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQV 281
Cdd:cd15161 155 RekasrgaLVSLAVAFTIPFVTTVTCYLLIIRSLRTGKREEKPlkdKAIKMIILVLTIFLICFVPYHISRYIYILSHNGA 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4504683  282 iQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15161 235 -GASCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
53-325 2.66e-29

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 114.25  E-value: 2.66e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVN-GWIFGTFLCKVVSLLKEVNFY 131
Cdd:cd15155   5 AVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNrHWPFGDSLCKISGTAFLTNIY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  132 SGILLLACISVDRYLAIVHATRTLT-QKRYLVKFICLSIWGLSLLLALPVLLFrRTVYSSNVSPACYEdmGNNTANWRML 210
Cdd:cd15155  85 GSMLFLTCISVDRFLAIVYPFRSRTiRTRRNSAIVCAGVWILVLSGGISASLF-STTNVSNTSTTCFE--GFSKSIWKTY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  211 LR---ILPQSFGFIVPLLIMLFCYGFTLRTLFK----AHMG-QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVI 282
Cdd:cd15155 162 LSkitIFIEVVGFIIPLLLNLTCSSLVLRTLRKpatlSQIGtNKEKVLKMILVHVAIFVVCFVPYNSILFLYALVRSQAI 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  283 QeTCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15155 242 A-NCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
50-325 3.43e-29

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 114.06  E-value: 3.43e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYsRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15117   2 LSLVIYSSAFVLGTLGNGLVIWVTGF-RMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGfhWPFGWFLCKLYSTLVV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRY-LVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSpACYEDMG--NNT 204
Cdd:cd15117  81 FNLFASVFLLTLISLDRCVSVLWPVWARNHRTPaRAALVAVGAWLLALALSGPHLVFRDTRKENGCT-HCYLNFDpwNET 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 A-NWRMLLRILPQSF----------GFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLla 273
Cdd:cd15117 160 AeDPVLWLETVVQRLsaqvitrfvlGFLVPLVIIGGCYGLIAARLWREGWVHSSRPFRVLTAVVAAFFLCWFPFHLVS-- 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4504683  274 dtLMRTQVIQETCERRNHIDRALD-ATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15117 238 --LLELVVILNQKEDLNPLLILLLpLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
50-316 5.47e-29

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 113.41  E-value: 5.47e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15194   2 FLPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLgpWRSGSFLCKGSSYIIS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRT-LTQKRYLVKFICLSIWgLSLLLALPVLLFRRTVYSSNVSPACYEDMGNN-TA 205
Cdd:cd15194  82 VNMYCSVFLLTCMSLDRYLAIVLPLVSrKFRTKHNAKVCCTCVW-MLSCLLGLPTLLSRELKKYEEKEYCNEDAGTPsKV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRIlpqsFGFIVPLLIMLFCYGFTLRTL------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRT 279
Cdd:cd15194 161 IFSLVSLI----VAFFLPLLSILTCYCTIIWKLchhyqkSGKHQKKLRKSIKIVFIVVAAFVFSWMPFNLFKALAIASGL 236
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4504683  280 QViQETCERRNHIDRALDATEILGILHSCLNPLIYAF 316
Cdd:cd15194 237 QV-EVTCLPYTLAQLGMEVSAPLAFANSCANPFIYYF 272
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
51-322 6.18e-29

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 113.28  E-value: 6.18e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVG--RSVTDVYLLNLALADLLFALTLPIWAAS--KVNGWIFGTFLCKVVSLLK 126
Cdd:cd15098   3 VPVVFGLIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATiySLPEWVFGAFMCKFVHYFF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLT-QKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPA--CYEDMGNn 203
Cdd:cd15098  83 TVSMLVSIFTLVAMSVDRYIAVVHSRTSSSlRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTASNQtfCWENWPE- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  204 tANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLF-------KAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd15098 162 -KQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHkklknmsKKSERSKKKTAQTVLVVVVVFGISWLPHHIIHLWVEF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4504683  277 MRTQVIQETCERRnhidralDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15098 241 GDFPLTQASFVLR-------ITAHCLAYANSCVNPIIYAFLSENFR 279
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
50-322 2.94e-28

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 111.16  E-value: 2.94e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEV 128
Cdd:cd15970   2 LISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRhWPFGSLLCRLVLSVDAI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANW 207
Cdd:cd15970  82 NMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVaKMVNLGVWVFSILVILPIIIFSNTAPNSDGSVACNMQMPEPSQRW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFGFIVPLLIMLFCYGFTLRTL----FKAHMGQKHRAMR----VIFAVVLIFLLCWLPYNLVLLADTLMrt 279
Cdd:cd15970 162 LAVFVVYTFLMGFLLPVIAICLCYILIIVKMrvvaLKAGWQQRKRSERkitlMVMMVVTVFVICWMPFYVVQLVSVFV-- 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  280 qviqetcerRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15970 240 ---------GQHDATVSQLSVILGYANSCANPILYGFLSDNFK 273
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
49-324 9.29e-28

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 109.86  E-value: 9.29e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAAS--KVNGWIFGTFLCKVVSLLK 126
Cdd:cd14971   1 WIVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATiyPLPGWVFGDFMCKFVHYFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTL---TQKRYLVkfICLSIWGLSLLLAL-PVLLFRRTVYSSNVSPACYEDMGN 202
Cdd:cd14971  81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLhirTPRNALA--ASGCIWVVSLAVAApVLALHRLRNYTPGNRTVCSEAWPS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  203 NTANWRMLLRILpqSFGFIVPLLIMLFCYGFTLRTLFKAHMGQ---------KHRAMRVIFAVVLIFLLCWLPYNLVLLA 273
Cdd:cd14971 159 RAHRRAFALCTF--LFGYLLPLLLICVCYAAMLRHLWRVAVRPvlsegsrraKRKVTRLVLVVVVLFAACWGPIHAILLL 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4504683  274 DTLmrtqviqetceRRNHIDRALDATEI----LGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd14971 237 VAL-----------GPFPLTYATYALRIwahcLAYSNSAVNPVLYAFLSEHFRKA 280
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
54-325 1.38e-27

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 109.45  E-value: 1.38e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFY 131
Cdd:cd15158   6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKgqWLFGDFLCRISSYALYVNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  132 SGILLLACISVDRYLAIVHATRTL---TQKRylVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSpACYEDMGNNTANWR 208
Cdd:cd15158  86 CSIYFMTAMSFTRFLAIVFPVQNLnlvTVKK--ARIVCVGIWIFVTLTSSPFLMSGSHDTETNKT-KCFEPPQSNQQLTK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  209 ML-LRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKH------RAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQV 281
Cdd:cd15158 163 LLvLNYISLVVGFIIPFLVILICYAMIIRTLLKNTMKARKqqssrkKAIRMIIIVLLAFLVSFMPYHIQRTIHLHFLSRK 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4504683  282 iQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15158 243 -DSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRRL 285
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
53-325 1.46e-27

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 109.42  E-value: 1.46e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYsRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNF 130
Cdd:cd15114   5 VLYAVVFLVGVPGNALVAWVTGF-EAKRSVNAVWFLNLAVADLLCCLSLPILAVPIAQDghWPFGAAACKLLPSLILLNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATRTLTQKR-YLVKFICLSIWGLSLLLALPVLLFRRTV---YSSNVspACYEDMGNNTAN 206
Cdd:cd15114  84 YASVLLLTAISADRCLLVLRPVWCQNHRRaRLAWIACGAAWLLALLLTVPSFIYRRIHqehFPEKT--VCVVDYGGSTGV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLlRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLadtlmrtqVIQETC 286
Cdd:cd15114 162 EWAV-AIIRFLLGFLGPLVVIASCHGVLLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYHVVGL--------IIAASA 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  287 ERRNHIDRALDATEI---LGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15114 233 PNSRLLANALKADPLtvsLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
52-325 3.24e-27

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 108.70  E-value: 3.24e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVNF 130
Cdd:cd15154   4 LVGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHyWPFGNFLCQFSGSIFQMNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWGLSLLLALPVLLFRRT---VYSSNVSPACYEDMGNNTAN 206
Cdd:cd15154  84 YGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVaRLLCLAVWALILGGSVPAAIVHSSsdcLLHGEKVYRCFESFSDNDWK 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVL---IFLLCWLPYNLVLLADTLMRTQVIQ 283
Cdd:cd15154 164 GLLPLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQGRRRKTVRLLLVnlvIFLICFVPYNTTLAVYGLLRANLVE 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  284 ETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15154 244 DTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
50-322 3.24e-27

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 108.74  E-value: 3.24e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15921   2 FYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNshWPFGDIACRIILYVLY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTL-TQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSpACYEdMGNNTAN 206
Cdd:cd15921  82 VNMYSSIYFLTALSVFRYLALVWPYLYLrVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGST-RCLE-LAHDAVD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK------AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADtLMRTQ 280
Cdd:cd15921 160 KLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKpspalgRTRPSRRKACALIIISLGIFLVCFLPYHIVRTIH-LITER 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  281 VIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15921 239 QIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFR 280
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
49-322 1.54e-26

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 106.61  E-value: 1.54e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASK--VNGWIFGTFLCKVVSLLK 126
Cdd:cd15096   1 IVVPVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDyvLPTWPFGDVWCKIVQYLV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLT--QKRYLVKFIClSIWGLSLLLALPVLLFRRTVYSSNVSPACYedMGNNT 204
Cdd:cd15096  81 YVTAYASVYTLVLMSLDRYLAVVHPITSMSirTERNTLIAIV-GIWIVILVANIPVLFLHGVVSYGFSSEAYS--YCTFL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILPQSF---GFIVPLLIMLFCYGFTLRTLFKAHMG----------QKHRAMRVIFAVVLIFLLCWLPYNLVL 271
Cdd:cd15096 158 TEVGTAAQTFFTSFflfSYLIPLTLICVLYMLMLRRLRRQKSPggrrsaesqrGKRRVTRLVVVVVVVFAICWLPIHIIL 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504683  272 LADTLMR------TQVIQETCerrnhidraldatEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15096 238 LLKYYGVlpetvlYVVIQILS-------------NCLAYGNSCVNPILYAFLSQNFR 281
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
49-322 1.56e-26

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 106.60  E-value: 1.56e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAAS-KVNGWIFGTFLCKVVSLLK 126
Cdd:cd15095   1 WLVPLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTdLAFLVCCVPFTAALyATPSWVFGDFMCKFVNYMM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTL-TQKRYLVKFICLSIWGLSLLLALPVLLFRRTV--YSSNVSPACYEDMGNN 203
Cdd:cd15095  81 QVTVQATCLTLTALSVDRYYAIVHPIRSLrFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEegYWYGPQTYCREVWPSK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  204 TANWRMLLRILPQSfgFIVPLLIMLFCYGFTLRTLFKA--------------HMGQKHRAMRVIFAVVLIFLLCWLPYNL 269
Cdd:cd15095 161 AFQKAYMIYTVLLT--YVIPLAIIAVCYGLILRRLWRRsvdgnnqseqlserALRQKRKVTRMVIVVVVLFAICWLPNHV 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504683  270 VLLADTLmrtqviqetcERRNHIDRALDATEILGIL----HSCLNPLIYAFIGQKFR 322
Cdd:cd15095 239 LNLWQRF----------DPNFPETYATYALKIAALClsyaNSAVNPFVYAFMGENFR 285
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
51-318 2.68e-26

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 106.03  E-value: 2.68e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVN 129
Cdd:cd14975   3 GCTLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGtWDFGLAACKGCVYVCAVS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVH--ATRTLTQKRYLVKfICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEdmgNNTANW 207
Cdd:cd14975  83 MYASVFLITLMSLERFLAVSRpfVSQGWRAKALAHK-VLAIIWLLAVLLATPVIAFRHVEETVENGMCKYR---HYSDGQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCE 287
Cdd:cd14975 159 LVFHLLLETVVGFAVPFTAVVLCYSCLLRRLRRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSELIGGSKMAG 238
                       250       260       270
                ....*....|....*....|....*....|..
gi 4504683  288 RRNHIDRALDATEI-LGILHSCLNPLIYAFIG 318
Cdd:cd14975 239 TLGKVAEAGRPIAGaLAFLSSSINPLLYAFAA 270
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
49-322 3.27e-26

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 105.54  E-value: 3.27e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLK 126
Cdd:cd15160   1 IFLPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHhnWTFGPLSCKVVGFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHA--TRTLTQKRYLVKfICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYED--MGN 202
Cdd:cd15160  81 YTNIYASIGFLCCIAVDRYLAVVHPlrFRGLRTRRFALK-VSASIWVLELGTHSVFLGHDELFRDEPNHTLCYEKypMEG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  203 NTANWRMlLRILpqsFGFIVPLLIMLFCYGFTLRTLFKAH---MGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTlMRT 279
Cdd:cd15160 160 WQASYNY-ARFL---VGFLIPLSLILFFYRRVLRAVRQSPsleREEKRKIIGLLLSIVVIFLLCFLPYHVVLLVRS-VIE 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  280 QVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15160 235 LVQNGLCGFEKRVFTAYQISLCLTSLNCVADPILYIFVTEDVR 277
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
50-324 3.58e-26

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 105.63  E-value: 3.58e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15968   2 LLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRdrWLFGDFMCRLVRFLFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQK-RYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSpACYEDMGNNTAN 206
Cdd:cd15968  82 FNLYGSILFLTCISVHRYLGICHPMRPWHKEtRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRT-VCYDLAPPALFP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMG-------QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRT 279
Cdd:cd15968 161 HYVPYGMALTVSGFLLPFSIILWCYCLVVRTLCRTLGPaeppaqaRRRKSIRTIVTVTLLFALCFLPFHITRTIYLAVRV 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4504683  280 QViQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd15968 241 TP-GVPCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKFGRR 284
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
54-322 7.05e-26

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 104.84  E-value: 7.05e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFY 131
Cdd:cd15088   6 VFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDgqWYFGEVMCKIITALDANNQF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  132 SGILLLACISVDRYLAIVHATRTLT-QKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNT-ANWRM 209
Cdd:cd15088  86 TSTYILTAMSVDRYLAVVHPIRSTKyRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTFCYVSLPSPDdLYWFT 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  210 LLRILpqsFGFIVPLLIMLFCYGFTLRTLFK-------AHMGQKH-RAMRVIFAVVLIFLLCWLPYNLVlladtlmrtQV 281
Cdd:cd15088 166 IYHFI---LGFAVPLVVITVCYILILHRLARgvapgnqSHGSSRTkRVTKMVILIVVVFIVCWLPFHVV---------QL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  282 IQETCERRNH-IDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15088 234 VNLAMNRPTLaFEVAYFLSICLGYANSCLNPFVYILVSENFR 275
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
54-316 1.35e-25

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 104.16  E-value: 1.35e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLKEVNFYS 132
Cdd:cd15156   6 VFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVqRNWPFGDLLCKISVTLFYTNMYG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  133 GILLLACISVDRYLAIVHA--TRTLTQKRYlVKFICLSIWGLSLLLALPVLLFRRT-VYSSNVSPACYEDMGNNTanWRM 209
Cdd:cd15156  86 SILFLTCISVDRFLAIVYPfrSKTLRTKRN-AKIVCAAVWLTVLAGSLPASFFQSTnNQLNNNSETCFENFSSKT--WKT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  210 LLR---ILPQSFGFIVPLLIMLFCYGFTLRTLFKA-----HMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQV 281
Cdd:cd15156 163 YLSkivIFIEIVGFFIPLILNVTCSTMVLKTLRRPntlsrSKLNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVRTQT 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 4504683  282 IQeTCERRNHIDRALDATEILGILHSCLNPLIYAF 316
Cdd:cd15156 243 FK-NCSVVAAVRTMYPITLCIAVSNCCFDPIVYYF 276
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
49-316 1.55e-25

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 103.97  E-value: 1.55e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLK 126
Cdd:cd15159   1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGfdWPFGDWLCRLTALLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHaTRTLTQKRYL--VKFICLSIWGlSLLLALPVLLFRRTVYSSNVSPACYEdMGNNT 204
Cdd:cd15159  81 YINTYAGVNFMTCLSVDRYIAVVH-PLRRHRLRKVkvVRYICVFVWV-LVFLQTLPLLFMPMTKEMGGRITCME-YPNFE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILPQSF-GFIVPLLIMLFCYGFTLRTLFKA--------HMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLaDT 275
Cdd:cd15159 158 KIKRLPLILLGACViGFGVPVGIILFCYSQITLKLCRTakenplteKSGHHKKACNVILLVLLVFVVCFSPYHLNII-QF 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4504683  276 LMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAF 316
Cdd:cd15159 237 MIRKLLYQPSCSELKAFKISLQITVCLMNLNCCLDPFIYFF 277
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
54-321 2.20e-25

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 103.62  E-value: 2.20e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAA--SKVNGWIFGTFLCKVVSLLKEVNFY 131
Cdd:cd15967   6 VYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVyyLKGRKWIFGQVFCKITRFCFNLNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  132 SGILLLACISVDRYLAIVHATRTLTQ-KRYLVKFICLSIWGLSLLLALPVLLFRRTvysSNVSPACYEDMGNNTANWRML 210
Cdd:cd15967  86 GSIGFLTCISVYRYLAIVHPMRVMGRiTTTHSVVISALVWLLVVIQSLPDLFFSKT---NSNGTKCFDTTFNDYLESYLT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  211 LRILPQSFGFIVPLLIMLFCYGFTLRTLF-KAHM--GQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCE 287
Cdd:cd15967 163 YSLGWTVTGFVIPLLIILGCYGHVVVVLCrNNNVdkGLKQRCLKLVIILIVLFSVCYIPYHVFRNLNLLSRILQKQGSCT 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 4504683  288 R-RNHIDRALDATEILGILHSCLNPLIYAFIGQKF 321
Cdd:cd15967 243 QwFRGIYIAHQVSRGLVCLNSALNPLVYLMGSEDI 277
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
54-323 4.06e-25

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 102.63  E-value: 4.06e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAAS-KVNGWIFGTFLCKVVSLLKEVNFYS 132
Cdd:cd15973   6 IYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASaALQHWPFGSAMCRTVLSVDGINMFT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  133 GILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACyeDMGNNTANWRMLL 211
Cdd:cd15973  86 SVFCLTVLSVDRYIAVVHPLRAARYRRPTVaKMINICVWILSLLVISPIIIFADTATRKGQAVAC--NLIWPHPAWSAAF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  212 RILPQSFGFIVPLLIMLFCY--------GFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMrtqviq 283
Cdd:cd15973 164 VIYTFLLGFLLPVLAIGLCYiliigkmrAVALKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNLFL------ 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4504683  284 etcerrNHIDRALD-ATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15973 238 ------PRLDATVNhASLILSYANSCANPILYGFLSDNFRR 272
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
51-324 6.32e-25

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 102.21  E-value: 6.32e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSR-VGRSVTDVYLLNLALADLLFALTLPIWAAS--KVNGWIFGTFLCKVVSLLKE 127
Cdd:cd15097   3 VPVVFSLIFLLGTVGNSLVLAVLLRSGqSGHNTTNLFILNLSVADLCFILFCVPFQATiySLEGWVFGSFLCKAVHFFIY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHA--TRTLTQKRYLVKFICLsIWGLSLLLALPVLLFRRTVYSSNvSPACyedMGNNTA 205
Cdd:cd15097  83 LTMYASSFTLAAVSVDRYLAIRYPlrSRELRTPRNAVAAIAL-IWGLSLLFAGPYLSYYDLIDYAN-STVC---MPGWEE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKA---------HMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd15097 158 ARRKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAvdpleamseSKRAKRKVTKMIIIVTALFCLCWLPHHVVILCYLY 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4504683  277 MRTQVIQETCERRNhidraldATEILGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd15097 238 GDFPFNQATYAFRL-------LSHCMAYANSCLNPIVYALVSKHFRKG 278
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
49-325 1.42e-24

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 101.53  E-value: 1.42e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLK 126
Cdd:cd15377   1 YYLPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPalIFYYFNKTDWIFGDAMCKLQRFIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLTQ-KRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTA 205
Cdd:cd15377  81 HVNLYGSILFLTCISVHRYTGVVHPLKSLGRlKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQ--------KHRAMRVIFAVVLIFLLCWLPY----NLVLLA 273
Cdd:cd15377 161 RSYFIYSMCTTVAMFCVPFILILGCYGLIVRALIYKDMKYteennaplRRKSIYLVIIVLTVFAVSYLPFhvmkTLNLRA 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 4504683  274 DTLMRTqviQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15377 241 RLDFQT---PAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
50-322 2.27e-24

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 100.60  E-value: 2.27e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15162   2 FLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGnnWIFGEALCRLVTVAFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRY-LVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTAN 206
Cdd:cd15162  82 GNMYCSILLLTCISIDRYLAIVHPMGHRRLRARrYALGTCLAIWLLALLVTLPLYLVKQTIFLPALDITTCHDVLPEQLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 ---WRMLLRILpQSFGFIVPLLIMLFCYGFTLRTL----FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRT 279
Cdd:cd15162 162 vgdWFYYFLSL-AIVGFLIPFILTASCYVATIRTLaaleDENSEKKKKRAIKLAATVLAIFIICFAPSNLLLLAHYSLIS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  280 QVIQEtcerrnHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15162 241 SSGTG------HLYFAYLLALCLSTLNSCIDPFIYYFVSKEFR 277
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
51-322 5.19e-24

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 99.64  E-value: 5.19e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15091   3 ITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLmNSWPFGDVLCKIVISIDYYN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTLTQKRYL-VKFICLSIWGLSLLLALPVLLF--RRTVYSSNVSPACYEDMGNNTAN 206
Cdd:cd15091  83 MFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLkAKIINICIWLLSSSVGISAIVLggTKVREDVDSTECSLQFPDDDYSW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHM--GQKH------RAMRVIFAVVLIFLLCWLPYNLVLLADTLMR 278
Cdd:cd15091 163 WDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLlsGSREkdrnlrRITRLVLVVVAVFVVCWTPIHIFILVEALGS 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 4504683  279 TqviqetcerrNHIDRALDATEI---LGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15091 243 V----------SHSTAAVSSYYFciaLGYTNSSLNPILYAFLDENFK 279
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
52-322 1.21e-23

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 98.30  E-value: 1.21e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYsRVGRSVTDVYLLNLALADLLFALTLPIWAASKV--NGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15115   4 LVVLSLTFLLGVPGNGLVIWVAGL-KMKRTVNTIWFLNLAVADLLCCLSLPFSIAHLLlnGHWPYGRFLCKLLPSIIVLN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHAT-----RTLTqkryLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGnnt 204
Cdd:cd15115  83 MFASVFTLTAISLDRFLLVIKPVwaqnhRSVL----LACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGYDFLV--- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 anwrmLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQK-HRAMRVIFAVVLIFLLCWLPYNLVLLAdTLMRTQVIQ 283
Cdd:cd15115 156 -----AITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFAKSqSKTFRVIIAVVVAFFVCWAPYHIIGIL-SLYGDPPLS 229
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4504683  284 ETCERRNHIDRAldateiLGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15115 230 KVLMSWDHLSIA------LAYANSCLNPVLYVFMGKDFK 262
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
57-325 1.97e-23

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 97.97  E-value: 1.97e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   57 LVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILL 136
Cdd:cd14989   9 FLFPIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIEVFNLNEKYYDIAVLCTFMSLFLQINMYSSIFF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  137 LACISVDRYLAIVHATRT--LTQKRYlVKFICLSIWGLSLLLALPVLLFRRTVYSSNVsPACYEDMGNntanwrmlLRIL 214
Cdd:cd14989  89 LTWMSFDRYIALAKVMKSspLRTMQH-ARLSCGLIWMASISATLLPFTAVQAQHTGEV-HFCFADVRE--------IQWL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  215 PQSFGFIVPLLIMLFCYGFTLRTLFKAHMG-----QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERR 289
Cdd:cd14989 159 EVTLGFIIPFSIIGLCYSLIVRVLVRAQKHrrlrpRRQKALRMILVVVLVFFICWLPENVFISIQLLQGTQEPSESYDES 238
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4504683  290 NHIDRALDA--TEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14989 239 FRHNHPLTGhiVNLAAFSNSCLNPLIYSFLGETFRDKL 276
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
51-325 5.58e-23

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 96.58  E-value: 5.58e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVN-GWIFGTFLCKVVSLLKEV 128
Cdd:cd15001   2 VIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATAdLLLLVFCVPLKTAEYFSpTWSLGAFLCKAVAYLQLL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRY-LVKFICLSIWGlsLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANW 207
Cdd:cd15001  82 SFICSVLTLTAISIERYYVILHPMKAKSFCTIgRARKVALLIWI--LSAILASPVLFGQGLVRYESENGVTVYHCQKAWP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFGFIV----PLLIMLFCYGftlrtlfkahMGQKHRAMRVIFAVVLIFLLCWLPynlVLLADTLMRTQVIq 283
Cdd:cd15001 160 STLYSRLYVVYLAIViffiPLIVMTFAYA----------RDTRKQVIKMLISVVVLFAVCWGP---LLIDNLLVSFDVI- 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  284 etCERRNHIDRALDAT-EILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15001 226 --STLHTQALKYMRIAfHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
49-325 7.90e-23

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 96.52  E-value: 7.90e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPI-WAASKVNGWIFGTFLCKVVSLLK 126
Cdd:cd15203   1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSdLLLCLVSLPFtLIYTLTKNWPFGSILCKLVPSLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLsIWGLSLLLALPVLLFRRTVYSSNVSP-----ACYEDMG 201
Cdd:cd15203  81 GVSIFVSTLTLTAIAIDRYQLIVYPTRPRMSKRHALLIIAL-IWILSLLLSLPLAIFQELSDVPIEILpycgyFCTESWP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  202 NntANWRMLLRILPQSFGFIVPLLIMLFCY---GFTLRTLFKAHMG--------------QKHRAMRVIFAVVLIFLLCW 264
Cdd:cd15203 160 S--SSSRLIYTISVLVLQFVIPLLIISFCYfriSLKLRKRVKKKRGkrtlssrrrrselrRKRRTNRLLIAMVVVFAVCW 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504683  265 LPYNLV-LLADTLMRTQVIQetcerrNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15203 238 LPLNLFnLLRDFEPLPQIDG------RHFYLIFLICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
53-325 8.63e-23

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 96.41  E-value: 8.63e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAA-SKVNGWIFGTFLCKVVSLLKEVNFY 131
Cdd:cd15972   5 LVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAqNALSYWPFGSFMCRLVMTVDAINQF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  132 SGILLLACISVDRYLAIVHATRTLT-QKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNvspACYEDMGNNTANWRML 210
Cdd:cd15972  85 TSIFCLTVMSVDRYLAVVHPIRSSKwRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMG---TCHIAWPEPAQVWRAG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  211 LRILPQSFGFIVPLLIMLFCY----------GFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPY---NLVLLADTLM 277
Cdd:cd15972 162 FIIYTATLGFFCPLLVICLCYllivvkvrssGRRVRATSTKRRGSERKVTRMVVIVVAAFVLCWLPFyalNIVNLVCPLP 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4504683  278 RTQVIQETcerrnhidraLDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15972 242 EEPSLFGL----------YFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
50-325 9.86e-23

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 95.97  E-value: 9.86e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYsRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15119   2 VSIVIYIVAFVLGVPGNAIVIWVTGF-KWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDfhWPFGVWLCKINSFVAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHAT---RTLTQKRYLvkFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNN- 203
Cdd:cd15119  81 LNMFASVLFLTVISLDRYISLAHPVwshRYRTLKSAL--ILCGIVWLSAAAISGPALYFRDTMELSINVTICFNNFHKHd 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  204 ---TANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTlmrtq 280
Cdd:cd15119 159 gdlIVMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILEL----- 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4504683  281 VIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15119 234 SIHHSSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
51-322 1.16e-22

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 95.83  E-value: 1.16e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVN 129
Cdd:cd15090   3 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGtWPFGNILCKIVISIDYYN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTL---TQKRYLVKFICLSIwglSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTAN 206
Cdd:cd15090  83 MFTSIFTLCTMSVDRYIAVCHPVKALdfrTPRNAKIVNVCNWI---LSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHM--GQKH------RAMRVIFAVVLIFLLCWLPYNLVLLADTLMR 278
Cdd:cd15090 160 WENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMlsGSKEkdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKALVT 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4504683  279 T-QVIQETCERRNHIdraldateILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15090 240 IpETTFQTVSWHFCI--------ALGYTNSCLNPVLYAFLDENFK 276
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
50-322 1.24e-22

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 96.00  E-value: 1.24e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP-IWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15094   2 ISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPfLIVTMILKYWPFGAAMCKIYMVLTSI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKR-YLVKFICLSIWGLSLLLALPVLLFRRTV-----YSSN-VSPACYEDMG 201
Cdd:cd15094  82 NQFTSSFTLTVMSADRYLAVCHPIRSMRYRTpFIAKVVCATTWSISFLVMLPIILYASTVpdsgrYSCTiVWPDSSAVNG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  202 NNTANWRMLLrilpqsFGFIVPLLIMLFCYGFT---LRTLFKAHMGQKHRA-----MRVIFAVVLIFLLCWLPYNLVLLA 273
Cdd:cd15094 162 QKAFTLYTFL------LGFAIPLLLISVFYTLVilrLRTVGPKNKSKEKRRshrkvTRLVLTVISVYIICWLPYWAFQVH 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4504683  274 DTLMRTQVIQETCErrnhIDRALDATeILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15094 236 LIFLPPGTDMPKWE----ILMFLLLT-VLSYANSMVNPLLYAFLSENFR 279
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
49-322 1.43e-22

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 95.55  E-value: 1.43e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLK 126
Cdd:cd15157   1 VIYPTVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGshWVFGDIACRIMSYSL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATR--TLTQKRYlVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSpaCYEDMGNNT 204
Cdd:cd15157  81 YVNMYCSIYFLTVLSIVRFLAIVHPFKlwKVTSIKY-ARILCAVIWIFVMAASSPLLSKGTSKYNSQTK--CLDLHPSKI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILpQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKH------RAMRVIFAVVLIFLLCWLPYNlvlladtLMR 278
Cdd:cd15157 158 DKLLILNYIV-LVVGFILPFCTLSICYILIIKALLKPRVPQSKlrvshkKALLTIIITLILFLLCFLPYH-------ILR 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4504683  279 TQVIQETCERRNH--IDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15157 230 TVHLMQWSEGQCNlrLHKAVVITLCLAAANSCLDPLLYYFAGENFK 275
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
50-325 4.10e-22

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 94.67  E-value: 4.10e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLAL--ADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKE 127
Cdd:cd15390   2 LWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVadLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRyLVKFICLSIWGLSLLLALPVLLFRRT----VYSSNVSPACY----ED 199
Cdd:cd15390  82 TTVAASVFTLMAISIDRYIAIVHPLRPRLSRR-TTKIAIAVIWLASFLLALPQLLYSTTetyyYYTGSERTVCFiawpDG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  200 MGNNTANWRMLLRILPQsfgFIVPLLIMLFCY---GFTLR--------TLFKA-HMGQKHRAMRVIFAVVLIFLLCWLPY 267
Cdd:cd15390 161 PNSLQDFVYNIVLFVVT---YFLPLIIMAVAYtrvGVELWgsktigenTPRQLeSVRAKRKVVKMMIVVVVIFAICWLPY 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4504683  268 NLVLLADTlmrtqvIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15390 238 HLYFILTY------LYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
50-322 5.12e-22

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 94.04  E-value: 5.12e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILySRVGRSVTDVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKE 127
Cdd:cd15372   2 LVPSLYTLVFLVGLPANGLALWVLA-TQVKRLPSTIFLINLAVADLLLILVLPfkISYHFLGNNWPFGEGLCRVVTAFFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHA--TRTLTQKRYLVkFICLSIWGLSLLLALPVLLFRRT--VYSSNVS---PACYEDM 200
Cdd:cd15372  81 GNMYCSVLLLMCISLDRYLAVVHPffARTLRSRRFAL-CMCTAIWLIAAALTLPLTLQRQSypLERLNITlchDVLPLDE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  201 GNNTANWRMLLRILpqsFGFIVPLLIMLFCYGFTLRTLfkAHMGQKH-RAMRVIFAVVLIFLLCWLPYNLVLLadtlmrT 279
Cdd:cd15372 160 QDTYLFYYFACLAV---LGFLLPLVVILFCYGSVLHTL--LRSGQRYgHAMKLTVLVLVSFVLCFTPSNLLLL------L 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  280 QVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15372 229 HYSDPTLDDGGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
51-322 5.38e-22

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 94.25  E-value: 5.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVN 129
Cdd:cd15089   3 ITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMEtWPFGELLCKAVLSIDYYN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTLT-QKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWR 208
Cdd:cd15089  83 MFTSIFTLTMMSVDRYIAVCHPVKALDfRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDGAVVCMLQFPSPSWYWD 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  209 MLLRILPQSFGFIVPLLIMLFCYGF------TLRTLFKAHMGQKH--RAMRVIFAVVLIFLLCWLPYNLVLLADTLMrtq 280
Cdd:cd15089 163 TVTKICVFIFAFVVPILVITVCYGLmilrlrSVRLLSGSKEKDRNlrRITRMVLVVVAAFIICWTPIHIFVIVWTLV--- 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  281 viqETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15089 240 ---DIDRRNPLVVAALHLCIALGYANSSLNPVLYAFLDENFK 278
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
51-325 8.40e-22

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 93.58  E-value: 8.40e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT---LPIWAASKVNGWIFGTFLCKVVSLLKE 127
Cdd:cd15392   3 IILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFcvpFSFIALLILQYWPFGEFMCPVVNYLQA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRYlVKFICLSIWGLSLLLALPVLLFRRTVYSSNVS---PACYEDMGNNT 204
Cdd:cd15392  83 VSVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQ-ALLLIAVIWIFALATALPIAITSRLFEDSNAScgqYICTESWPSDT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILpqSFGFIVPLLIMLFCYGFTLRTLF--------KAHMGQ-----KHRAMRVIFAVVLIFLLCWLPYNLVL 271
Cdd:cd15392 162 NRYIYSLVLM--ILQYFVPLAVLVFTYTRIGIVVWakrtpgeaENNRDQrmaesKRKLVKMMITVVAIFALCWLPLNILN 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4504683  272 LAdtlmrtQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15392 240 LV------GDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
50-325 1.01e-21

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 93.01  E-value: 1.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKE 127
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVaLLVMPFSAVYTLLGyWPFGPVLCRFWIALDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATR---TLTQKRylVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPaCYEDMGNNT 204
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRyrqLMTKKR--ALIMIAAVWVYSLLISLPPLVGWRDETQPSVVD-CECEFTPNK 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLrilpqSFGFIVPLLIMLFCYGFTLRTLFKahmgqKHRAMRVIFAVVLIFLLCWLPYNLVLLadtlmrtqvIQE 284
Cdd:cd14967 158 IYVLVSS-----VISFFIPLLIMIVLYARIFRVARR-----ELKAAKTLAIIVGAFLLCWLPFFIIYL---------VSA 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4504683  285 TCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14967 219 FCPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
49-325 1.10e-21

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 93.24  E-value: 1.10e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKE 127
Cdd:cd15378   1 YYLPTMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYSNGqWLFGDFLCKSNRYLLH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRT-LTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSpAC--YEDMGNNT 204
Cdd:cd15378  81 ANLYSSILFLTFISIDRYLLIKYPFREhILQKKRSAVAISLAIWVLVTLELLPILTFIGPNLKDNVT-KCkdYASSGDAT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 AN--WRMLLRIlpqsFGFIVPLLIM-LFCYGFTLrtLFKAHMGQK------HRAMRVIFAVVLIFLLCWLPYNL---VLL 272
Cdd:cd15378 160 NSliYSLFLTV----TGFLIPLCVMcFFYYKIAL--FLKNRNRQLanatsfEKPLTLVILAVVIFSVLFTPYHVmrnVRI 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4504683  273 ADTLMRTQVIQETcerRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15378 234 ASRLDSIGVSECT---LIIIKSLYIVTRPIAFLNSVINPVFYFLMGDHFREML 283
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
55-322 1.10e-21

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 93.28  E-value: 1.10e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   55 YALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKEVNFYS 132
Cdd:cd15373   7 YGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPllVYYYADENDWPFSEALCKIVRFLFYTNLYC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  133 GILLLACISVDRYLAIVHATRTLT--QKRYlVKFICLSIWGLSLLLALPVLLFRRTVySSNVSPACYEDMGNNTANWRML 210
Cdd:cd15373  87 SILFLLCISVHRFLGVCYPVRSLRwlKVRY-ARIVSVVVWVIVLACQSPVLYFVTTS-DKGGNITCHDTSSPELFDQFVV 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  211 LRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMG------QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTqvIQE 284
Cdd:cd15373 165 YSSVMLVLLFCVPFVVILVCYALMVRKLLKPSAGtstnsrSKKKSVKMIIIVLAVFILCFLPFHVTRTLYYSFRS--MDL 242
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4504683  285 TCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15373 243 SCGTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFR 280
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
51-322 1.27e-21

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 93.01  E-value: 1.27e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVN 129
Cdd:cd15092   3 IVVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGfWPFGNALCKTVIAIDYYN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTL-TQKRYLVKFICLSIWGLSLLLALPVLLFrRTVYSSNVSPACYEDMGNNTANWR 208
Cdd:cd15092  83 MFTSTFTLTAMSVDRYVAICHPIKALdVRTPHKAKVVNVCIWALASVVGVPVMVM-GSAQVEDEEIECLVEIPTPQDYWD 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  209 MLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHM--GQKH------RAMRVIFAVVLIFLLCWLPYNLVLLADTLMrtq 280
Cdd:cd15092 162 PVFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRLlsGSKEkdrnlrRITRLVLVVVAVFVGCWTPIQIFVLAQGLG--- 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  281 vIQETCERRNHIDRALDAteiLGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15092 239 -VQPSSETAVAILRFCTA---LGYVNSSLNPVLYAFLDENFK 276
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
110-325 1.46e-21

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 92.87  E-value: 1.46e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  110 NGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRrtVYS 189
Cdd:cd15152  63 KSWPFGKFLCMFCFYLKYVNMYASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAGWLVVCVGCLPFPLLR--QSQ 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  190 SNVSPACYED--MGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAH-----MGQKHRAMRVIFAVVLIFLL 262
Cdd:cd15152 141 DTNPTCCFADlpLRNVGLTTSVIMLTIAELTGFVTPLLIVLYCSWKTVMSLREKTpvlqdLGEKKKALKMILTCAVVFLI 220
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504683  263 CWLPYNLVLLADTLMRTQVIqETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15152 221 CFAPYHISFPLDFLVKSNKI-KSCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKRRL 282
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
53-325 2.06e-21

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 92.52  E-value: 2.06e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKEVNF 130
Cdd:cd15368   5 VVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPfqIVYHIQRNHWIFGKPLCNVVTVLFYANM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATRTLT--QKRYLVKfICLSIWGLSLLLALPVLLFRRTVYSSNVS-PACYE----DMGNN 203
Cdd:cd15368  85 YSSILTMTCISIERYLGVVYPMRSMRwrKKRYAVA-ACIGMWLLVLTALSPLERTDLTYYVKELNiTTCFDvlkwTMLPN 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  204 TANWRMLLRILpQSFGFIVPLLIMLFCYGFTLRTLFKAHM----GQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRT 279
Cdd:cd15368 164 IAAWAAFLFTL-FILLFLIPFIITVYCYVLIILKLVQTSErygrEQKRRAIYLALIVLLVFITCFAPNNFILLAHMVSRL 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4504683  280 QViqetcerRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15368 243 FY-------GKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
53-325 3.77e-21

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 91.79  E-value: 3.77e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKEVNF 130
Cdd:cd15374   5 VSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPtlIYYYADHNHWPFGVVACKIVRFLFYANL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATRTLTQ-KRYLVKFICLSIWGLSLLLALPVLLFrRTVYSSNVSPACYEDMGNNTANWRM 209
Cdd:cd15374  85 YCSILFLTCISVHRYVGICHPIRALRWvKPRHAYLICASVWLVVTVCLVPNLIF-VTTSRKDNITLCHDTTRPEEFDHYV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  210 LLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMG--------QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRtqV 281
Cdd:cd15374 164 HYSSAVMVLLFGIPCLVIVVCYGLMARRLCKPRVGssrqqgpsSKKRSLKTIIMVLTVFAICFVPFHITRTLYYVAR--L 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4504683  282 IQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15374 242 LKADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRRRL 285
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
50-325 4.23e-21

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 91.76  E-value: 4.23e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV--NGWIFGTFLCKVVSLLKE 127
Cdd:cd14988   2 VLFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMldYTWLWGSFLCKFTHYFYF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVK-FICLSIWGLSLLLALPVLLFRRTVYSsnVSPACYEDMGNNT-A 205
Cdd:cd14988  82 ANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRrALCAGIWVLSAIIPLPEVVHMQLLDG--VEPMCLFLAPFETyD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQeT 285
Cdd:cd14988 160 EWALAVSLLTLIIGFLIPFSIIAVFNVLTARYIRTAGRPESRRHCLLIYAYILVFVVCWLPYHVTLLLLTLHGSHISL-H 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4504683  286 CERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14988 239 CNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
53-321 9.82e-21

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 90.63  E-value: 9.82e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGR--SVTDVYLLNLALADLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15122   5 IFLLLAALLGLPGNGFIIWSILWKMKARgrSVTCILILNLAVADGAVLLLTPFFITFLTrKTWPFGQAVCKAVYYLCCLS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTLT-QKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSN----VSPACYEDMGNNT 204
Cdd:cd15122  85 MYASIFIIGLMSLDRCLAVTRPYLAQSlRKKALVRKILLAIWLLALLLALPAFVYRHVWKDEGmndrICEPCHASRGHAI 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMllrilPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADtLMRTQVIQE 284
Cdd:cd15122 165 FHYTF-----ETLVAFVLPFGVILFSYSVILVRLKGARFRRRARVEKLIAAIVVAFALLWVPYHVVNLLQ-VVANLAPGE 238
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4504683  285 TCERRNHIDRALDA-TEILGILHSCLNPLIYAFIGQKF 321
Cdd:cd15122 239 VLEKLGGAAKAARAgATALAFFSSSVNPLLYVFAAGDL 276
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
52-324 1.26e-20

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 90.14  E-value: 1.26e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15206   4 IPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSdLLLAVFCMPFTLVGQLlRNFIFGEVMCKLIPYFQAVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHA--TRTLTQKRYLVKFICLsIWGLSLLLALPVLLFRRTVYSSN-VSPACYEDMGNNTAN 206
Cdd:cd15206  84 VSVSTFTLVAISLERYFAICHPlkSRVWQTLSHAYKVIAG-IWLLSFLIMSPILVFSNLIPMSRpGGHKCREVWPNEIAE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 --WRMLLRIlpqsFGFIVPLLIMLFCYGFTLRTLFKAhmgqKHRAMRVIFAVVLIFLLCWLPY---NLVLLADTLMRTQV 281
Cdd:cd15206 163 qaWYVFLDL----MLLVIPGLVMSVAYGLISWTLLEA----KKRVIRMLFVIVVEFFICWTPLyviNTWKAFDPPSAARY 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  282 IQETcerrnhidrALDATEILGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd15206 235 VSST---------TISLIQLLAYISSCVNPITYCFMNKRFRQA 268
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
51-325 2.85e-20

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 89.57  E-value: 2.85e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVmLVILYSRVG--RSVTDVYLLNLALADLLFALTLPIWAASKV--NGWIFGTFLCKVVSLLK 126
Cdd:cd15926   3 ISIVYSVVCALGLVGNLLV-LYLMKSKQGwkKSSINLFVTSLAVTDFQFVLTLPFWAVENAldFTWLFGKAMCKIVSYVT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRT-LTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSN--VSPACYEDMGNN 203
Cdd:cd15926  82 AMNMYASVFFLTAMSVARYHSVASALKSkRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNeeLCLVKFPDNRGN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  204 TANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMG-----QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMR 278
Cdd:cd15926 162 AQFWLGLYHAQKVLLGFLIPLGIISLCYLLLVRFITDKNITgsstkRRSKVTKSVTIVVLSFFLCWLPNQALTTWGILIK 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 4504683  279 TQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15926 242 LNVVHFSYEYFTTQVYIFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
51-325 2.96e-20

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 89.49  E-value: 2.96e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLKEV 128
Cdd:cd15202   3 LIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVAdIMITLFNTPFTFVRAVnNTWIFGLFMCHFSNFAQYC 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLsIWGLSLLLALPVLLFRRT---VYSSNVS-PACYEDMGNNT 204
Cdd:cd15202  83 SVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAV-IWTLALAFALPHAICSKLetfKYSEDIVrSLCLEDWPERA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHM-------------GQKHRAMRVIFAVVLIFLLCWLPYNLVL 271
Cdd:cd15202 162 DLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMpgdatteryfalrRKKKKVIKMLMVVVVLFALCWLPFNIYV 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4504683  272 LADTLmrtqviqETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15202 242 LLLSS-------KPDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
54-325 3.21e-20

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 89.12  E-value: 3.21e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSG 133
Cdd:cd15171   6 LCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGGSLGNPTCKVLVALSSVGLHSE 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  134 ILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSI--WGLSLLLALPVLLFRRTVYSSNvSPAC-----YEDMGNNTAn 206
Cdd:cd15171  86 ALFNVLLTVQASRVFFHGRLASSARRVAPCGIIASVlaWLTAFLVTLPEFVFYKPQMDSQ-KSKCafsrpHFLPAEETF- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLfkAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQEtC 286
Cdd:cd15171 164 WKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQ--RFRERQRDLSKLVFAIMVVFLLMWAPYNIALFLSAFKEHFSLRD-C 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4504683  287 ERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15171 241 KSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRRL 279
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
50-322 3.41e-20

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 89.13  E-value: 3.41e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAAS-KVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15971   2 FLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQvALVHWPFGKAICRVVMTVDGI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKR-YLVKFICLSIWGLSLLLALPVLLFrRTVYSSNVSPACYEDMGNNTANW 207
Cdd:cd15971  82 NQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKpRTAKMINMAVWGVSLLVILPIMIY-AGVQTKHGRSSCTIIWPGESSAW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFGFIVPLLIMLFCYGFT--------LRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLP---YNLVLLADTL 276
Cdd:cd15971 161 YTGFIIYTFILGFFVPLTIICLCYLFIiikvkssgIRVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPfyiFNVSSVSVSI 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4504683  277 MRTQVIQETcerrnhidraLDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15971 241 SPTPGLKGM----------FDFVVVLSYANSCANPILYAFLSDNFK 276
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
49-322 5.64e-20

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 88.55  E-value: 5.64e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15165   1 SLQLVVYIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSSKKQWPLGRTLCSFLESLYFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHA--TRTLTQKRYLVkFICLSIWGLSLLLALPVLLFRRtvySSNVSPACYEDMGNNTan 206
Cdd:cd15165  81 NMYGSILIIVCISVDRYIAIRHPflAKRLRSPRKAA-IVCLTIWVFVWAGSIPIYSFHD---KPTNNTRCFHGFSNKT-- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAH-----MGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQV 281
Cdd:cd15165 155 WSKKVIVVVEEFGFLIPMAVMVFCSVQIIRTLLDMRrpeqpKVKQNKSVKIVLSNLVVFLVCFTPYHLGIFLQFLVKNDI 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4504683  282 IQEtCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15165 235 IND-CSTKQSIRLFVQVSMCLANVNCCLDAICYYFILKEFR 274
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
53-323 5.94e-20

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 88.62  E-value: 5.94e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPI-WAASKVNGWIFGTFLCKVVSLLKEVNF 130
Cdd:cd15393   5 ILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIgLFSIPFqFQAALLQRWVLPRFMCPFCPFVQVLSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATRTLTQKRyLVKFICLSIWGLSLLLALPVLLFRRTVY-----SSNVSPACYEDmgNNTA 205
Cdd:cd15393  85 NVSVFTLTVIAVDRYRAVIHPLKARCSKK-SAKIIILIIWILALLVALPVALALRVEEltdktNNGVKPFCLPV--GPSD 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK------------AHMGQ-KHRAMRVIFAVVLIFLLCWLPYNLVLL 272
Cdd:cd15393 162 DWWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGtkapgnaqdvrdDEILKnKKKVIKMLIIVVALFALCWLPLQTYNL 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 4504683  273 adtlmrTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15393 242 ------LNEIKPEINKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKR 286
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
50-322 8.06e-20

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 88.26  E-value: 8.06e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLKEV 128
Cdd:cd15087   2 ALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLlQQWPFGELLCKLILSIDHY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYL---AIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRtVYSSNVS-PACYEDMGNNT 204
Cdd:cd15087  82 NIFSSIYFLTVMSVDRYLvvlATVRSRRMPYRTYRAAKIVSLCVWLLVTIIVLPFTVFAG-VYSNELGrKSCVLSFPSPE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAM-----RV---IFAVVLIFLLCWLPYNL---VLLA 273
Cdd:cd15087 161 SLWFKASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKALdkakkKVtlmVLVVLAVCLFCWTPFHLstvVALT 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4504683  274 DTLMRTQVIqetcerrnhIDRALDATEiLGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15087 241 TDLPQTPLV---------IGISYFITS-LSYANSCLNPFLYAFLDDSFR 279
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
51-322 8.36e-20

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 87.93  E-value: 8.36e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15974   3 IPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAiSYWPFGSFLCRLVMTVDGVN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWGLSLLLALPVLLFrrtvysSNVSP---ACYEDMGNNTA 205
Cdd:cd15974  83 QFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVaKLINATVWTLSFLVVLPVIIF------SDVQPdlnTCNISWPEPVS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILPQSFGFIVPLLIMLFCY--------GFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLM 277
Cdd:cd15974 157 VWSTAFIIYTAVLGFFGPLLVICLCYllivikvkSSGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIV 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4504683  278 rtqviqeTCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15974 237 -------ILPEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFK 274
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
49-322 9.85e-20

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 87.82  E-value: 9.85e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYS-RVGRSVTdVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLL 125
Cdd:cd15375   1 YYLPVMYSIIFIVGFPGNIIAIFVYLFKmRPWKSST-IIMLNLALTDLLYVTSLPFLIYYYINGesWIFGEFMCKFIRFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  126 KEVNFYSGILLLACISVDRYLAIVHATRTL-TQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSpACYEDMGNNT 204
Cdd:cd15375  80 FHFNLYGSILFLTCFSIFRYVVIVHPLRAFqVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKNNRT-ICLDFTSSDN 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKA-HMGQKH--RAMRVIFAVVLIFLLCWLPYNLVLLADtlMRTQV 281
Cdd:cd15375 159 LNTIWWYNWILTVLGFLLPLVIVTLCYTRIIYTLAKGpHTGSASkqKARRLIILILLVFYVCFLPFHILRVVR--IETRL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4504683  282 IQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15375 237 PPVSCCLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQ 277
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
51-325 2.19e-19

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 86.70  E-value: 2.19e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALAD---LLFALTLPIWAAS-KVNGWIFGTFLCKVVSLLK 126
Cdd:cd15002   2 VPILLGVICLLGFAGNLMVIGILLNNARKGKPSLIDSLILNLSAadlLLLLFSVPFRAAAySKGSWPLGWFVCKTADWFG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVsPACYEDMGNNTAN 206
Cdd:cd15002  82 HACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGV-YLCILCIPPLAHE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAhmGQKHRAMRV----------IFAVVLIFLLCWLPYNLVLLAdtl 276
Cdd:cd15002 161 FMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRR--GTKTQNLRNqirsrklthmLLSVVLAFTILWLPEWVAWLW--- 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4504683  277 mrtqVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15002 236 ----LIHIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
50-316 2.30e-19

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 86.74  E-value: 2.30e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15369   2 FVPSVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGndWLFGEAMCRVVTAAFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRY-LVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDM--GNNT 204
Cdd:cd15369  82 CNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLrRASFTCAAIWLLSIAGVVPLLLSEQTIQIPDLGITTCHDVlnEQLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHM----GQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQ 280
Cdd:cd15369 162 MGYYVYYFSIFSCLFFFVPLIITTVCYVSIIRCLSSSSDvansSKKTRALFMAVAVFCVFVICFGPTNVLLLAHYVRFAY 241
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4504683  281 viqetcerRNHIDRALDATEI---LGILHSCLNPLIYAF 316
Cdd:cd15369 242 --------TSTNDASYFAYLLcvcVGSISCCLDPLIYYY 272
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
55-325 3.51e-19

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 86.39  E-value: 3.51e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   55 YALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVN-GWIFGTFLCKVVSLLKEVNFYSG 133
Cdd:cd15153   7 YIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQhTWPFGRFLCLLCFYLKYLNMYAS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  134 ILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVySSNVSPACYEDMGNNTANWRMLLRI 213
Cdd:cd15153  87 ICFLTCISIQRCFFLLHPFKARDWKRRYDVGISAAVWIVVGLACLPFPLLRSKS-LSNNNRSCFADLGMKKLNFGAAIAM 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  214 L--PQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQ-----KHRAMRVIFAVVLIFLLCWLPYNLVLLAdTLMRTQVIQETC 286
Cdd:cd15153 166 MtvAELFGFVIPLFIIAWCTWKTENSLRQRNKQQqstseKQKALRMVRMCAAVFFICFAPYHINFLF-YLMVSESIITNC 244
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4504683  287 ERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15153 245 EVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQDQL 283
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
53-322 3.53e-19

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 85.97  E-value: 3.53e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYS 132
Cdd:cd15923   5 AIYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYRRESAGLQKLCNFVLSLYYINMYV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  133 GILLLACISVDRYLAIVHATRTLTQKRYLVKF-ICLSIWGLSLLLALPVLLFrrtvYSSNVSPACYEDMgnnTANWRMLL 211
Cdd:cd15923  85 SIFTITAISVDRYVAIRYPLRARELRSPRKAAvVCAVIWVLVVTISIPYFLL----DSSNEKTMCFQRT---KQTESLKV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  212 RILPQSFGFIVPLLIMLFCYGFTLRTLFK--AHMGQ---KHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQViqeTC 286
Cdd:cd15923 158 FLLLEIFGFLLPLIIMTFCSARVIHTLQKrlDDVGSrseTKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVGKSY---SC 234
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4504683  287 ERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15923 235 DSKLIIHFFLQSAFCLSDMNCCLDAFCYYFATKEFR 270
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
52-323 3.86e-19

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 86.28  E-value: 3.86e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRS----------VTDVYLLNLALADLLfaltlpIWAASkvNGWIFGTFLCKV 121
Cdd:cd14986   4 VAVLGVLFVFTLVGNGLVILVLRRKRKKRSrvnifilnlaIADLVVAFFTVLTQI------IWEAT--GEWVAGDVLCRI 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  122 VSLLKEVNFYSGILLLACISVDRYLAIVHATRTLtQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYeDMG 201
Cdd:cd14986  76 VKYLQVVGLFASTYILVSMSLDRYQAIVKPMSSL-KPRKRARLMIVVAWVLSFLFSIPQLVIFVERELGDGVHQCW-SSF 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  202 NNTANWRMLLRILPQSFgFIVPLLIMLFCYGFTLRTLFK--------------------AHMGQ--------KHRAMRVI 253
Cdd:cd14986 154 YTPWQRKVYITWLATYV-FVIPLIILSYCYGRILRTIWIrsrqktdrpiaptamscrsvSCVSSrvslisraKIKTIKMT 232
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  254 FAVVLIFLLCWLPYNLVLLADTLMRTQVIQEtcerrnhidRALDATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd14986 233 LVIILAFILCWTPYFIVQLLDVYAGMQQLEN---------DAYVVSETLASLNSALNPLIYGFFSSHLSF 293
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
49-317 5.13e-19

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 85.60  E-value: 5.13e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLK 126
Cdd:cd15365   1 YLFPFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGdnWTLSGFVCIFSAFLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATR-TLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMgnNTA 205
Cdd:cd15365  81 YTNFYTSTALLTCIALDRYLAVVHPLKfMHLRTIRTALSVSVAIWLLEICFNAVILTWEDSFHESSSHTLCYDKF--PLE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILPQSFGFIVPLLIMLFCYgftlRTLFKA-------HMGQKHRAMRVIFAVVLIFLLCWLPYNLVLladtLMR 278
Cdd:cd15365 159 DWQARLNLFRICLGYLLPLLIILFCY----WKIYQAvrsnqatEDQEKKKIFKLLLLITVTFVICFTPYHVVL----LIR 230
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4504683  279 TQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFI 317
Cdd:cd15365 231 SIVEPCDCRNAKWLYTLYKITVALTSLNCIADPFLYCFV 269
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
110-322 5.27e-19

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 85.92  E-value: 5.27e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  110 NGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVH-ATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVY 188
Cdd:cd15922  64 SHWPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVHyNWKSLWKKKSFMKKLCLGVWLLLFVQGLPFFFVLKTSV 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  189 SSNVSpACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQ------KHRAMRVIFAVVLIFLL 262
Cdd:cd15922 144 IDGKT-KCLSIHQSELSLLYFVWNFVLLILGFLLPFGVSLTCYALLGASIAKMNSNNargramKAKSLQMIGISLVIFII 222
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  263 CWLPYNLVLLADTLMRtQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15922 223 CFVPLHVTRTVGVVVK-LFYPESCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFR 281
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
50-322 7.71e-19

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 85.23  E-value: 7.71e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15370   2 FLPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGnnWIYGEALCKVLIGFFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVS-PACYEDMGNNTAN 206
Cdd:cd15370  82 GNMYCSILFMTCLSVQRYWVIVNPMSHSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFIPALDiTTCHDVLPEQLLV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFG-FIVPLLIMLFCYGFTLRTLFKA----HMGQKH-RAMRVIFAVVLIFLLCWLPYNLVLLAD-TLMRT 279
Cdd:cd15370 162 GDMFNYFLSLAIGvFLFPAFLTAVAYVLMIRALKSSindeSIEKKRkRAIKLIVTVLVMYLICFTPSNLLLVVHyFLLKN 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  280 QViqetcerRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15370 242 QG-------QSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
50-315 8.69e-19

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 85.13  E-value: 8.69e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVM-LVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLK 126
Cdd:cd15376   2 FLWPILGVEFLVAVLGNGLALwLFVTRERRPWHTGVVFSFNLAVSDLLYALSLPLLAAYYYPPknWRFGEAACKLERFLF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVH---ATRTLTQKRylVKFICLSIWGLSLLLALPVLLFRRTVYSSNvspACYEDMGnn 203
Cdd:cd15376  82 TCNLYGSIFFITCISLNRYLGIVHpffTRSHVRPKH--AKLVSLAVWLLVAALSAPVLSFSHLEVERH---NKTECLG-- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  204 TANWRMLLRILPQS-----FGFIVPLLIMLFCYGFTLRTLFKAH---MGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADT 275
Cdd:cd15376 155 TAVDSRLPTYLPYSlflavVGCGLPFLLTLASYLAIVWAVLRSPgitTLEKRKVAALVAVVVALYAVSFVPYHILRNLNL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4504683  276 LMRTQVIQETCERRNHidRALDATEILGILHSCLNPLIYA 315
Cdd:cd15376 235 YRRLQWLKAAASLRIY--FAYQVTKGLVTLNMCIHPLLYM 272
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
52-325 1.29e-18

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 84.98  E-value: 1.29e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15207   4 IVSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSdLLVGVFCMPFTLVDNIlTGWPFGDVMCKLSPLVQGVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLsIWGLSLLLALPVLLFRRTVYSSNVS----PACYE---DMGN 202
Cdd:cd15207  84 VAASVFTLVAIAVDRYRAVVHPTEPKLTNRQAFVIIVA-IWVLALAIMIPQALVLEVKEYQFFRgqtvHICVEfwpSDEY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  203 NTANWRMLLrilpqSFGFIVPLLIMLFCYGFTLRTLFK---------------AHMGQKHRAMRVIFAVVLIFLLCWLPY 267
Cdd:cd15207 163 RKAYTTSLF-----VLCYVAPLLIIAVLYVRIGYRLWFkpvpgggsasreaqaAVSKKKVRVIKMLIVVVVLFALSWLPL 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4504683  268 NLVLLADTLMRTQVIQetceRRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15207 238 HTVTMLDDFGNLSPNQ----REVLYVYIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
49-322 1.30e-18

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 84.81  E-value: 1.30e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV--NGWIFGTFLCKVVSLLK 126
Cdd:cd16001   1 ILLPVTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAmrDRWPFGDFLCKLVRFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLTQK-RYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSpACYE----DMG 201
Cdd:cd16001  81 YTNLYGSILFLTCISVHRFLGVCYPIRSLAYRtRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRT-VCYDltspDNF 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  202 NNTANWRMLLRILpqsfGFIVPLLIMLFCYGFTLRTLF----KAHMGQKHRA--MRVIFAVVLIFLLCWLPYNLVLLADT 275
Cdd:cd16001 160 GNYFPYGMVLTVT----GFLIPFLIILLCYCLMIKSLIrseeAAGVGKAARAksIRTILLVCGLFALCFVPFHITRTIYL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 4504683  276 LMRTQVIQEtCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd16001 236 FVRVYLVQD-CPLLQFVSLAYKIWRPLVSFNSCINPLLYFLSGDSNR 281
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
59-322 2.86e-18

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 83.68  E-value: 2.86e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   59 FLLSLLGNSLvMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV--NGWIFGTFLCKVVSLLKEVNFYSGILL 136
Cdd:cd15120  11 FLVGLVVNGL-YLWVLGFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLmdNHWAFGTVLCKVLNSTLSVGMFTSVFL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  137 LACISVDRYLAIVHA--TRTLTQKRYLVKfICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYED-------MGNNTANW 207
Cdd:cd15120  90 LTAISLDRYLLTLHPvwSRQHRTNRWASA-IVLGVWISAILLSIPYLAFRETRLDEKGKTICQNNyalstnwESAEVQAS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQS----FGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNlvlLADTLMRTQVIQ 283
Cdd:cd15120 169 RQWIHVAMFVfrflLGFLLPFLIITFCYVRMALKMKERGLARSSKPFKVMFTAVVSFFVCWLPYH---LHSGLVLTRGRP 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  284 ETcerrnhidrALDATEILGILHSCLN----PLIYAFIGQKFR 322
Cdd:cd15120 246 PS---------LTDITLLLTVGTTCFNtcftPVLYLFVGENFK 279
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
50-322 3.44e-18

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 83.31  E-value: 3.44e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVmLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15371   2 LIPAVYIIVVVLGVPSNAII-LWMLFFRLRSVCTAIFYANLAISDLLFCITLPFKIVYHLNGnnWVFGETMCRIITITFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHA--TRTLTQKRYLVkFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGN--- 202
Cdd:cd15371  81 GNMYCSILLLTCISINRYLAIVHPfiYRSLPKKTYAV-LICALVWTIVFLYMLPFFILKQTYYLKELNITTCHDVLPece 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  203 NTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLfKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADtlmrtQVI 282
Cdd:cd15371 160 QNSNFQFYYFISMAVFGFLIPLVITIFCYISIIRTL-NAYEHKWFWYVKITALVLIIFTICFAPSNVILIIH-----HFN 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4504683  283 QETCERRNHIDRALDATeILGILHSCLNPLIYaFIGQKFR 322
Cdd:cd15371 234 YYYFNNDNLYSIYLIAL-CLGSLNSCLDPFLY-FLMSKWR 271
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
53-322 7.57e-18

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 82.49  E-value: 7.57e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDV--YLLNLALADLLFALTLPIWAA--SKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15147   5 IVYSIIFVLGLIANCYVLWVFARLYPSKKLNEIkiFMVNLTIADLLFLITLPFWIVyyHNEGNWILPKFLCNVAGCLFFI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAI---VHATRTLTQKRYLVkfICLSIWGLSLLLALPVLLFRRT---VYSSNVSPACYEDMGN 202
Cdd:cd15147  85 NTYCSVAFLGVISYNRYQAVtrpIKTAQSTTRKRGII--ISVAIWVIIVASASYFLFMDSTntvKIDSGNFTRCFEGYEK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  203 NTANWRMLLRILpQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQ------KHRAMRVIFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd15147 163 DNSKPVLIIHFI-IIGLFFLVFLLILVCNLVIARTLLSQPVQGqrnagvKRRALWMVCTVLAVFVICFVPHHVVQGPWTL 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 4504683  277 MRTQVIQET-CERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15147 242 AVLQQWRYWdCQFRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFR 288
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
52-322 8.06e-18

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 82.52  E-value: 8.06e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT---LPIWAASKVNgWIFGTFLCKVVSLLKEV 128
Cdd:cd15205   4 VITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFcipFTLLQNISSN-WLGGAFMCKMVPFVQST 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTV------YSSNVSPACYEDMGN 202
Cdd:cd15205  83 AVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLevkydfLYEKRHVCCLERWYS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  203 NTANWRMLLRILpqSFGFIVPLLIMLFCY---------------GFTLRTLFKAHMG----QKHRAMRVIFAVVLIFLLC 263
Cdd:cd15205 163 PTQQKIYTTFIL--VILFLLPLTTMLFLYsrigyelwikkrvgdASVLQTIHGIEMSkisrKKKRAVKMMVTVVLLFAVC 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4504683  264 WLPYNLVlladTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15205 241 WAPFHVV----HMMIEYSNLENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFK 295
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
49-322 8.10e-18

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 82.47  E-value: 8.10e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLK 126
Cdd:cd14977   1 YVIMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGdLLLLLLCVPLNAYNLLtKDWLFGDVMCKLVPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLTQKRYlvKFICLS---IWGLSLLLALPVLLFR--RTVYSSNVSP--ACYED 199
Cdd:cd14977  81 VTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGAC--LSTCVKlavIWVGSVLLAVPEAVLStvARESSLDNSSltVCIMK 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  200 MGNNTA----NWRMLLRIlpqSFGFIVPLLIMLFCYGFTLRTLFKA----------HMGQKHRAMRVIFAVVLIFLLCWL 265
Cdd:cd14977 159 PSTPFAetypKARSWWLF---GCYFCLPLAFTAVCYLLMARTLIRAakeytrgtkkHMKQRRQLAKTVLCLVLVFAFCWL 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504683  266 PYNLVLLADTLMRTQViqeTCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd14977 236 PEHISNILRATLYNEV---LIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFR 289
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
53-325 1.30e-17

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 81.73  E-value: 1.30e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTdVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKEVNF 130
Cdd:cd15924   5 VLYTVIFFAGILLNGLAMWIFFHIPSKSSFI-IYLKNTVVADLLMILTFPfkILSDAGLGPWQLRTFVCRVTSVLFYFTM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATRTLTQKRYLV-KFICLSIWGLSLLLALPVLLF-RRTVYSSNVSpACYEDMGNNTANWR 208
Cdd:cd15924  84 YTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFaKILSVVVWALMFLLSLPNMILtNQQPREKNVK-KCSFLKSELGLKWH 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  209 MLLRILPQsFGFIVPLLIMLFCYGFTLRTLFKAHMGQ-------KHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQV 281
Cdd:cd15924 163 EIVNYICQ-VIFWIVFLLMIVCYTAITKKVYRSYRRVfrssssrRKKSNVKIFIIVAVFFVCFVPYHFARIPYTLSQTRD 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4504683  282 IQEtCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15924 242 VFD-CTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRESL 284
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
55-324 4.40e-17

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 80.55  E-value: 4.40e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   55 YALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV--NGWIFGTFLCKVVSLLKEVNFYS 132
Cdd:cd14992   7 LVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVvsLSWEYGHFLCKIVNYLRTVSVYA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  133 GILLLACISVDRYLAIVHA--TRTLTQKRYLVKFIClSIWGLSLLLALPVLLFRRT-----VYSSNVSPACYE-DMGNNT 204
Cdd:cd14992  87 SSLTLTAIAFDRYFAIIHPlkPRHRQSYTTTVIIII-TIWVVSLLLAIPQLYYATTevlfsVKNQEKIFCCQIpPVDNKT 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 AnwRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKA-------------HMGQKHRAMRVIFAVVLIFLLCWLPYNLVL 271
Cdd:cd14992 166 Y--EKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRkvpgfsikeverkRLKCKRRVIKMLVCVVVLFVICWLPFHLFF 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4504683  272 LadtlmrTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd14992 244 L------LRDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKN 290
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
49-325 8.73e-17

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 79.56  E-value: 8.73e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLk 126
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALAdLLMSVVGYPLSFYSNLSGrWSFGDPGCVIYGFA- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 evNFYSG---ILLLACISVDRYLAIVH-ATRTLTQKRYLVKFICLS-IWGLSLLLALPV--LLFRRTVYSSNVSPACYED 199
Cdd:cd14969  80 --VTFLGlvsISTLAALAFERYLVIVRpLKAFRLSKRRALILIAFIwLYGLFWALPPLFgwSSYVPEGGGTSCSVDWYSK 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  200 MGNNTA-NWRMLLrilpqsFGFIVPLLIMLFCYGFTLRTL---------------FKAHMGQKHRAMRVIFAVVLIFLLC 263
Cdd:cd14969 158 DPNSLSyIVSLFV------FCFFLPLAIIIFCYYKIYRTLrkmskraarrknsaiTKRTKKAEKKVAKMVLVMIVAFLIA 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504683  264 WLPYNLVLLADTLMRTQVIQetcerrnhiDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14969 232 WTPYAVVSLYVSFGGESTIP---------PLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
51-325 1.81e-16

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 78.64  E-value: 1.81e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV--NGWIFGTFLCKVVSLLKEV 128
Cdd:cd15012   2 FIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYliPSWPFGEVLCRMYQFVHSL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVH---ATRTLTQKRYLVkfICLSIWGLSLLLALPVLLFRRTVysSNVSPACYEDMGNNTA 205
Cdd:cd15012  82 SYTASIGILVVISVERYIAILHplrCKQLLTAARLRV--TIVTVWLTSAVYNTPYFVFSQTV--EILVTQDGQEEEICVL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILPQSFGFIV----PLLIMLFCYGFTLRTLFKAHMGQKHR-AMRVIFAVVLIFLLCWLPYNLVLLadtlmrTQ 280
Cdd:cd15012 158 DREMFNSKLYDTINFIVwyliPLLIMTVLYSKISIVLWKSSSIEARRkVVRLLVAVVVSFALCNLPYHARKM------WQ 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4504683  281 VIQETCERRNHIDRALDA-TEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15012 232 YWSEPYRCDSNWNALLTPlTFLVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
51-325 2.33e-16

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 78.38  E-value: 2.33e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVI-LYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV--NGWIFGTFLCKVVSLLKE 127
Cdd:cd15925   3 VALAYGLVCAIGLLGNLAVMYLLrNCARRAPPPIDVFVFNLALADFGFALTLPFWAVESAldFHWPFGGAMCKMVLTATV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRT-LTQKRYLVKFICLSIWGLSLLLALPVLLFrrtvysSNVSPACYED---MGNN 203
Cdd:cd15925  83 LNVYASVFLLTAMSVTRYWVVASAAGPgTHLSTFWAKIITLALWAAALLATVPTAIF------ATEGEVCGVElclLKFP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  204 TANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHR-----AMRVIFAVVLIFLLCWLPYNLVLLADTLMR 278
Cdd:cd15925 157 SNYWLGAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQHKVNQNNRqrqsvIARSVRLVVASFFLCWFPNHVVTFWGVLVK 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 4504683  279 TQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15925 237 FRAVPWNSTFYFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
51-325 2.55e-16

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 78.15  E-value: 2.55e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT-LPIWAASKVNG-WIFGTFLCKVVSLLKEV 128
Cdd:cd15389   3 LIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLnTPFTLVRFVNStWVFGKIMCHLSRFAQYC 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLsIWGLSLLLALPVLLFRRTV----YSSNVSPACYEDMGNNT 204
Cdd:cd15389  83 SVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAI-IWIMASCLSLPHAIYQKLVefeySNERTRSRCLPSFPEPS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK-------------AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVL 271
Cdd:cd15389 162 DLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWLrnaigdvtteqyvAQRRKKKKTIKMLMLVVLLFAICWLPLNCYH 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4504683  272 LadtLMRTQVIQetcerrnHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15389 242 V---LLSSHPIR-------SNSALFFAFHWLAMSSTCYNPFIYCWLNDSFRSEL 285
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
52-321 6.25e-16

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 76.78  E-value: 6.25e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVNF 130
Cdd:cd15121   4 IAILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGgWEFGSVVCKLCHYVCGVSM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIvhATRTLTQK---RYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACyeDMGNNTANW 207
Cdd:cd15121  84 YASIFLITLMSMDRCLAV--AKPFLSQKmrtKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINMKLC--IPYHPSVGH 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCE 287
Cdd:cd15121 160 EAFQYLFETITGFLLPFTAIVTCYSTIGRRLRSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQAGNAS 239
                       250       260       270
                ....*....|....*....|....*....|....
gi 4504683  288 RRNHIDRALDATEILGILHSCLNPLIYAFIGQKF 321
Cdd:cd15121 240 VLKAAKLARPNVTALAFLSSSVNPVLYAFAGGSL 273
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
51-322 9.14e-16

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 76.76  E-value: 9.14e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15132   3 VTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPfdLYRLWKSRPWIFGEFLCRLYHYISEG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRT---LTQKRylVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNT- 204
Cdd:cd15132  83 CTYATILHITALSIERYLAICFPLRAkvlVTRRR--VKCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDFSRECKHTp 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 -ANWRMLLRIL--PQSFGFIVPLLIMLFCYGFTLRTLFK----------AHMGQKHR-AMRVIFAVVLIFLLCWLPYNlv 270
Cdd:cd15132 161 yAVSSGLLGIMiwVTTTYFFLPMLCLSFLYGFIGRKLWKskndlrgpnaAARERSHRqTVRILAVVVLAFIICWLPFH-- 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4504683  271 lladtLMRTQVIQETCERRNHIDRALDATEI-LGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15132 239 -----IGRILFANTEDYRTMMFSQYFNIVAMqLFYLSASINPILYNLISRKYR 286
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
54-325 9.42e-16

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 76.39  E-value: 9.42e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRvGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNFY 131
Cdd:cd15339   6 FIGILCSTGLVGNILVLFTIIRSR-KKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGgeWVFGSPLCTIITSLDTCNQF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  132 SGILLLACISVDRYLAIVHATRTLTQK-RYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACyedMGNNTANWRML 210
Cdd:cd15339  85 ACSAIMTAMSLDRYIALVHPFRLTSLRtRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLESC---AFNLTSPDDVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  211 LRILPQSF-GFIVPLLIMLFCYGFTL-------RTLFKAHMG----QKHRAMR---VIFAVVLIFLLCWLPYNLVlladT 275
Cdd:cd15339 162 WYTLYQTItTFFFPLPLILICYILILcytwemyRKNKKAGRYntsiPRQRVMRltkMVLVLVGVFLVSAAPYHVI----Q 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 4504683  276 LMRTQVIQETCErrnhIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15339 238 LVNLSVSQPTLA----FYVSYYLSICLSYASSSINPFLYILLSGNFRKRL 283
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
50-322 1.03e-15

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 76.36  E-value: 1.03e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWA--ASKVNGWIFGTFLCKVVSLLKE 127
Cdd:cd15364   2 FLVVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTiyVSNNHKWPWGSLACKITGYIFF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHA--TRTLTQKRyLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSpaCYE--DMGNN 203
Cdd:cd15364  82 CNIYISILLLCCISIDRFVAVVYAleSRGRRRQR-IAAFISFLIFIVVGLVHSPVFIMREGQTEGSHT--CFEtlQMDTQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  204 TANWRmLLRILpqsFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIF---AVVLIFLLCWLPYNLVLLADTLMRTQ 280
Cdd:cd15364 159 VAGFY-YARFC---IGFAIPLAILIFTNYRIFRSIQTSTSLTPHQKAKVKYlaiAVIVIFLICFAPYHLVLLVRAIAFSL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  281 VIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15364 235 YPNGMCGFEERIYTPSVIFLCLSTVNSVADPIIYVLVSENVR 276
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
49-322 1.19e-15

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 76.58  E-value: 1.19e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNsLVMLVILYSRVGRSVTDVYLLNLALAD---LLFALTLP---IWAASkvNGWIFGTFLCKVV 122
Cdd:cd15382   1 LVSIIVYSVLFLIAAVGN-LTVLLILLRNRRRKRSRVNILLMHLAIadlLVTFIMMPleiGWAAT--VAWLAGDFLCRLM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  123 SLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKR---------YLVKFICLS--IWGLSLLLALPVLLFRRTVySSN 191
Cdd:cd15382  78 LFFRAFGLYLSSFVLVCISLDRYFAILKPLRLSDARRrgrimlavaWVISFLCSIpqSFIFHVESHPCVTWFSQCV-TFN 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  192 VSPACYEDMGNNTANWRMLlrilpqsfgFIVPLLIMLFCYGFTLRTLFK-----------------------AHMGQ-KH 247
Cdd:cd15382 157 FFPSHDHELAYNIFNMITM---------YALPLIIIVFCYSLILCEISRkskekkedvseksssvrlrrssvGLLERaRS 227
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504683  248 RAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQetcerrnhIDRAL-DATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15382 228 RTLKMTIVIVLVFIICWTPYFIMSLWYWFDRESASK--------VDPRIqKGLFLFAVSNSCMNPIVYGYFSIDLR 295
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
53-314 1.83e-15

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 75.50  E-value: 1.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNF 130
Cdd:cd15148   5 VFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNnqWTLGPLLCKVVGNLFYMNM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAI--VHATRTLTQKRYLVkFICLSIWGlslLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWR 208
Cdd:cd15148  85 YISIILLGFISLDRYLKInrSSRRQKFLTRKWSI-VACGVLWA---VALVGFVPMIVLTEKNEESTKCFQYKDRKNAKGK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  209 MLLRILPQSFGFIVPLLIMLfCYGFTLRTLFKA--------HMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLAdtLMRTQ 280
Cdd:cd15148 161 AIFNFLIVAMFWLVFLLLIL-SYGKIAKKLLRIsrdkpdfpNAAKYNRTARKSFFVLFIFTVCFVPYHAFRIF--YITSQ 237
                       250       260       270
                ....*....|....*....|....*....|....
gi 4504683  281 VIQETCERRNHIDRALDATEILGILHSCLNPLIY 314
Cdd:cd15148 238 LQNNSCYWKEILHKTNEIMLLLSAFNSCLDPVMY 271
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
49-272 2.60e-15

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 75.38  E-value: 2.60e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASK--VNGWIFGTFLCKVVSLLK 126
Cdd:cd15927   1 YVVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIytLDSWPFGEFLCKLSEFLK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFIC-LSIWGLSLLLALPVLLFRRTVY------SSNVSPACY-E 198
Cdd:cd15927  81 DTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTaASIWIVSILLAIPEAIFSHVVTftltdnQTIQICYPYpQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  199 DMGNNTANWRMLLRILPQsfgFIVPLLIMLFCYGFTLRTLFKAH-------MGQKHRAMR-------VIFAVVLIFLLCW 264
Cdd:cd15927 161 ELGPNYPKIMVLLRFLVY---YLIPLLIIGVFYVLMARHLIRSTrnigsgqNQAAQRQIEarkkvakTVLAFVVLFAVCW 237

                ....*...
gi 4504683  265 LPYNLVLL 272
Cdd:cd15927 238 LPRHVFML 245
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
51-325 3.83e-15

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 74.83  E-value: 3.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15928   3 VTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPldLYRLWRYRPWRFGDLLCRLMYFFSET 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVH---ATRTLTQKRylVKFICLSIW-GLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNT 204
Cdd:cd15928  83 CTYASILHITALSVERYLAICHplrAKVLVTRGR--VKLLIAVIWaVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK----------AHMGQKHR-AMRVIFAVVLIFLLCWLPYNL--VL 271
Cdd:cd15928 161 SSGLLSVMLWVSTSFFFVPMVCLSLLYGLIGRALWDrrqrsrtagaSRRDNNHRqTVRMLAVIVLAFVLCWLPFHVgrVI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4504683  272 LADTLMRTQVIQETCERRNHIdraldaTEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15928 241 FNHSRASTKHLHYVSQYFNLV------SFVLFYLSAAINPILYNLMSKRYRYAV 288
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
51-325 4.60e-15

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 74.47  E-value: 4.60e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEV 128
Cdd:cd15391   3 LINLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSdLIMALFCMPFTFTQIMLGhWVFPAPMCPIVLYVQLV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRyLVKFICLSIWGLSLLLALPVLLFRRT---VYSSNVSPACYEDMGNNTA 205
Cdd:cd15391  83 SVTASVLTNTAIGIDRFFAVIFPLRSRHTKS-RTKCIIASIWAISFSLSSVQLFAGRTqryGQYSEGRVLCGESWPGPDT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 nWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK-------------AHMGQKHRAMRVIFAVVLIFLLCWLP---YNL 269
Cdd:cd15391 162 -SRSAYTVFVMLLTYIIPLLILTSTYGYVGFRLWNrtapgnadkgrddMQIKSKRKVIKMLVFVVLMFGICWLPlhlFNL 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504683  270 VLLADTLMRtqviqetcERRNHIDRALDATEI-LGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15391 241 VQDFSTVFR--------NMPQHTTRLIYGACHwIAMSNSFVNPIIYLFMNDSFRSIL 289
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
50-325 4.87e-15

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 74.41  E-value: 4.87e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILY-SRVGRSVTdVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLK 126
Cdd:cd14991   2 ILPPLLILEFVLGLPGNVVALWIFCFhSRTWKANT-VYLFNLVLADFLLLICLPFRIDYYLRGehWIFGEAWCRVNLFML 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIV---HATRTLTQKRYLvkFICLSIWGLSLLLALPVLLFRRTVYSSNvSPACYEDMGNN 203
Cdd:cd14991  81 SVNRSASIAFLTAVALDRYFKVVhphHRVNRMSVKAAA--GVAGLLWALVLLLTLPLLLSTLLTVNSN-KSSCHSFSSYT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  204 TANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKH----RAMRVIFAVVLIFLLCWLPynlVLLADTLMRT 279
Cdd:cd14991 158 KPSLSIRWHNALFLLEFFLPLGLIVFCSVRIACNLRIRQSLGKQarvqRAIRLVFLVVIVFVLCFLP---SIIAGLLALV 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4504683  280 QVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14991 235 FKNLGSCRCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
52-325 7.65e-15

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 73.70  E-value: 7.65e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVN 129
Cdd:cd15979   4 ILLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSdLMLAVFCMPFTLIPNLMGtFIFGEVICKAVAYLMGVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIV------------HATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACY 197
Cdd:cd15979  84 VSVSTFSLVAIAIERYSAICnplqsrvwqtrsHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQCRHAWPSAQ 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  198 EDMGnntanWRMLLRILPqsfgFIVPLLIMLFCYGFTLRTLFKAHMGQKhRAMRVIFAVVLIFLLCWLPynlVLLADTLm 277
Cdd:cd15979 164 VRQA-----WYVLLLLIL----FFIPGVVMIVAYGLISRELYRGLLAKK-RVIRMLVVIVAMFFLCWLP---IFSANTW- 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4504683  278 rtQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15979 230 --RAFDPLSAHRALSGAPISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
53-322 9.26e-15

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 73.68  E-value: 9.26e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFgtFLCKVVSLLKEVNFYS 132
Cdd:cd15920   5 VMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRVAYQNTAGPL--SFCKIVGAFFYLNMYA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  133 GILLLACISVDRYLAIvhaTRTLTQ-KRYLVKFICLSIWGLSLLLALPVLLFrrtVYSSNVSPAC------YEDMGNNTA 205
Cdd:cd15920  83 SILFLSLISLDRYLKI---IKPLQQfKIHTVPWSSAASGGVWLLLLACMIPF---LFESRNEGPCdnkcfhFRSKGLTAG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILpqsfgFIVPLLIMLFCYGFTLRTLFKAHMGQKH--------RAMRVIFAVVLIFLLCWLPYNLVLLADTLM 277
Cdd:cd15920 157 GINLTAVVI-----FYILSLLFLYFYAKISHKLYKVSLGNAQqqikkaskRAIIKTFIVLAIFIVCFVPYHIVRVPYVLA 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4504683  278 RTQVIqETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15920 232 QIDVI-SSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFR 275
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
49-323 1.16e-14

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 73.04  E-value: 1.16e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGR----------SVTDVyllnlalaDLLFALTLPIWAASKVNGWIFGTFL 118
Cdd:cd15196   1 KVEIAVLATILVLALFGNSCVLLVLYRRRRKLsrmhlfilhlSVADL--------LVALFNVLPQLIWDITYRFYGGDLL 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  119 CKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLAL-PVLLFRRTVYSSNVspacY 197
Cdd:cd15196  73 CRLVKYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIAWVLSLLLSIpQLFIFSYQEVGSGV----Y 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  198 EDMGNNTANWRMLLRILPQSFG-FIVPLLIMLFCYGFTLRTLFKAhmgqKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd15196 149 DCWATFEPPWGLRAYITWFTVAvFVVPLIILAFCYGRICYVVWRA----KIKTVKLTLVVVACYIVCWTPFFVVQMWAAW 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4504683  277 MRTQVIQETcerrnhidrALDATEILGILHSCLNPLIY-AFIGQKFRH 323
Cdd:cd15196 225 DPTAPIEGP---------AFVIIMLLASLNSCTNPWIYlAFSGNLRRA 263
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
53-323 1.56e-14

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 72.87  E-value: 1.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNF 130
Cdd:cd15367   5 VVYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHdnWTYSELLCKICGILLYENI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATRtLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYS--SNVSPACYEDMGNNTanWR 208
Cdd:cd15367  85 YISIGFLCCISVDRYLAVVHPFR-FHAFRTMKAATLVSTVIWLKELMTCVFFFLHGEISkdKENHSVCFEHYPIKA--WE 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  209 MLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRV---IFAVVLIFLLCWLPYNLVLLADTlmrtqVIQET 285
Cdd:cd15367 162 HNINYYRFYAGFLFPIFLLSFSYCRILRAVRKSHGTQKSQKIQIkrlVLSTVVIFLVCFGPYHILLLVRS-----VFERD 236
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4504683  286 CERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15367 237 CNFAEGIFNYYHFSLLLTSFNCVADPVLYCFASESTYH 274
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
111-322 1.85e-14

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 72.40  E-value: 1.85e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  111 GWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRylVKFICLSIWGLSLLLALPVLLFRRTVYSS 190
Cdd:cd15213  65 RWIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLIIVQRQDKLNPHR--AKILIAVSWVLSFCVSFPPLVGWGKYEFP 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  191 NVSPACYEDMGNNTANWRMLLRILpqSFGFIVPLLIMLFCYGFTLRTL--FKAhmgqkhRAMRVIFAVVLIFLLCWLPYN 268
Cdd:cd15213 143 PRAPQCVLGYTESPADRIYVVLLL--VAVFFIPFLIMLYSYFCILNTVrsFKT------RAFTTILILFIGFSVCWLPYT 214
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 4504683  269 LVLLADTLMRTQviQETCERRNHIdraldatEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15213 215 VYSLLSVFSRYS--SSFYVISTCL-------LWLSYLKSAFNPVIYCWRIKKFR 259
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
51-324 1.86e-14

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 73.16  E-value: 1.86e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd14979   3 VTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSdLLILLVGLPVELYNFWWQypWAFGDGGCKLYYFLFE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVH--ATRTLTQKRYLVKFIcLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMG---- 201
Cdd:cd14979  83 ACTYATVLTIVALSVERYVAICHplKAKTLVTKRRVKRFI-LAIWLVSILCAIPILFLMGIQYLNGPLPGPVPDSAvctl 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  202 -NNTANWRMLLRILPQSFgFIVPLLIMLFCYGF------TLRTLFKAHMGQ-------------KHRAMRVIFAVVLIFL 261
Cdd:cd14979 162 vVDRSTFKYVFQVSTFIF-FVLPMFVISILYFRigvklrSMRNIKKGTRAQgtrnvelslsqqaRRQVVKMLGAVVIAFF 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504683  262 LCWLPYNlvllADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd14979 241 VCWLPFH----AQRLMFSYASKEDTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVA 299
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
49-316 2.18e-14

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 72.53  E-value: 2.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYsRVGRSVTDVYLLNLALADLLFALTLPIWA--ASKVNGWIFGTFLCKVVSLLK 126
Cdd:cd15118   1 VATICLHGIVSTLGIVENLLILWVVGF-RLRRTVISIWILNLALSDLLATLSLPFFTyyLASGHTWELGTTFCRIHSSIF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLTQKRY-LVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTA 205
Cdd:cd15118  80 FLNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVaAAKKICGVIWAMALINTIPYFVFRDVIERKDGRKLCYYNFALFSP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 N----------WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADT 275
Cdd:cd15118 160 SpdnnhpickqRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEV 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4504683  276 LMRTQViqetcERRNHIDRALDATEILGILHSCLNPLIYAF 316
Cdd:cd15118 240 MAHNQH-----SLRPLVIQGLPFATTLAFLNSVLNPVLYVF 275
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
54-322 2.92e-14

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 72.10  E-value: 2.92e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASK--VNGWIFGTFLCKVVSLLKEVNFY 131
Cdd:cd15167   6 FYYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAVDlgIAPWKLKIFHCQVTACLIYINMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  132 SGILLLACISVDRYLAIVHATRTL-TQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRML 210
Cdd:cd15167  86 LSIIFLGFVSIDRYLQLTHSSKLYrIQEPGFAKMISAVVWTLVLFIMVPNMAIPIKTIEEKPGVGCADFKTEFGRHWHVL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  211 LRILPQSFGFIVPLLIMLFcYGFTLRTLFKAHMGQKHR----AMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQEtC 286
Cdd:cd15167 166 TNFICMAIFLNFSAIILIS-NFLVIRKLYRNKDSEEYRnarqALVNILLVTAGYVICFVPYHIVRIPYTLSQSEVITD-C 243
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4504683  287 ERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15167 244 SLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFR 279
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
53-325 3.43e-14

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 72.19  E-value: 3.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTdVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKEVNF 130
Cdd:cd15149   5 VFYSLVFIVGILLNGVNFWIFFYVPSNKSFI-VYLKNIVFADLLMSLTFPfkILSDVELGPWQLNVIVCRYSAVIFYLNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATRT-LTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRM 209
Cdd:cd15149  84 YVGIIFFGLIGFDRYYKIVKPLHTsFVQNVGYSKALSVVVWMLMAVLSVPNIILTNQSFHEANYTKCARLKSELGIQWHK 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  210 LLRILPQSFGFIVPLLIMLFcYGFTLRTLFKAHM-------GQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVi 282
Cdd:cd15149 164 ASNYICVSIFWVVFLLLIIF-YVAISRKIYKSNQkfrrnstNMKAKSSRNIFSILFVFFVCFVPYHALRIPYTLSQTGA- 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  283 QETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15149 242 DYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFREML 284
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
51-325 4.67e-14

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 71.55  E-value: 4.67e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF------ALTLPIWAaskVNGWIFGTFLCKVVSL 124
Cdd:cd14997   3 VSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVllvcmpVALVETWA---REPWLLGEFMCKLVPF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  125 LKEVNFYSGILLLACISVDRYLAIVH---ATRTLTQKRYLVkfICLSIWGLSLLLALPVLLFR--RTVYSSNVSPACYED 199
Cdd:cd14997  80 VELTVAHASVLTILAISFERYYAICHplqAKYVCTKRRALV--IIALIWLLALLTSSPVLFITefKEEDFNDGTPVAVCR 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  200 MGNNTaNWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK----------AHMGQKHRAMR-VIF---AVVLIFLLCWL 265
Cdd:cd14997 158 TPADT-FWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGhpalesrradAANRHTLRSRRqVVYmliTVVVLFFVCLL 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504683  266 PYNLVLLADTLMRTQVIQetcerrnhidrALDA---------TEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14997 237 PFRVVTLWIIFAPDEDLQ-----------ALGLegylnllvfCRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
52-314 1.27e-13

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 70.54  E-value: 1.27e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLA----LADLLFALTLPIWAASKvnGWIFGTFLCKVVSLLKE 127
Cdd:cd15384   4 IVVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAiadlLVTFFCIPSEAIWAYTV--AWLAGNTMCKLVKYLQV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRrtVYSSNVSPACYE--DMGNNTA 205
Cdd:cd15384  82 FGLYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFH--VERGPFVEDFHQcvTYGFYTA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWR-MLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMG---------------------QKHRAMRVIFAVVLIFLLC 263
Cdd:cd15384 160 EWQeQLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDfqgleiytrnrgpnrqrlfhkAKVKSLRMSAVIVTAFILC 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 4504683  264 WLPYNLVLLADTLMRTQVIQetcerrnhiDRALDATEILGILHSCLNPLIY 314
Cdd:cd15384 240 WTPYYVIMIWFLFFNPYPLN---------DILFDVIFFFGMSNSCVNPLIY 281
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
53-322 1.30e-13

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 70.07  E-value: 1.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAA-SKVNG--WIFGTFLCKVVSLLKEVN 129
Cdd:cd15053   5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVyVEVNGgkWYLGPILCDIYIAMDVMC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTLTQKRylVKFICLSIwglslllalpvllfrRTVYSSNVSPACYEDMGNNTANWRM 209
Cdd:cd15053  85 STASIFNLCAISIDRYIAVTQPIKYARQKN--SKRVLLTI---------------AIVWVVSAAIACPLLFGLNNVPYRD 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  210 L---------LRILPQSFGFIVPLLIMLFCYGFTLRTLfkahmGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQ 280
Cdd:cd15053 148 PeecrfynpdFIIYSSISSFYIPCIVMLLLYYRIFRAL-----RREKKATKTLAIVLGVFLFCWLPFFTLNILNAICPKL 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  281 VIQETCERrnhiDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15053 223 QNQSCHVG----PALFSLTTWLGYVNSFLNPIIYTIFNIEFR 260
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
54-322 2.00e-13

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 69.90  E-value: 2.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKEVNFY 131
Cdd:cd15379   6 VYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPllIYNYTQKDYWPFGDFTCRLVRFQFYTNLH 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  132 SGILLLACISVDRYLAIVHATRTLTQK--RYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSpACYE----DMGNNTA 205
Cdd:cd15379  86 GSILFLTCISVQRYLGICHPLASWHKKkgKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRT-VCYDlsppARSTAYF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILpqsfGFIVPLLIMLFCYGFTLRTLFK---------AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd15379 165 PYGITLTRT----GFLLPFAARLACYCSMATILCRvviavavvaAPGEKRGKAARMIIVVAAVFLISFLPFHYTKTRYLQ 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4504683  277 MRTqVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15379 241 VRS-WDGGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFR 285
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
52-323 2.65e-13

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 69.35  E-value: 2.65e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTL----PIWAASKvnGWIFGTFLCKVVSLLKE 127
Cdd:cd15195   4 VLVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNmpmdAVWNYTV--EWLAGDLMCRVMMFLKQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSiWglsllLALPVLLFRRTVYSSNVSPACYE-------DM 200
Cdd:cd15195  82 FGMYLSSFMLVVIALDRVFAILSPLSANQARKRVKIMLTVA-W-----VLSALCSIPQSFIFSVLRKMPEQpgfhqcvDF 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  201 GNNTANW-RMLLRILPQSFGFIVPLLIMLFCYGFTLRTL------FKAHMGQKH-------------RAMRVIFAVVLIF 260
Cdd:cd15195 156 GSAPTKKqERLYYFFTMILSFVIPLIITVTCYLLILFEIskmakrARDTPISNRrrsrtnslerarmRTLRMTALIVLTF 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504683  261 LLCWLPYNLVLLADTLMRtqviqetcERRNHIDRALD-ATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15195 236 IVCWGPYYVLGLWYWFDK--------ESIKNLPPALShIMFLLGYLNPCLHPIIYGVFMKEIRN 291
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
52-325 3.42e-13

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 69.32  E-value: 3.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRS--VTDVYLLNLALADLLFALTLPIWAASKVN-GWIFGTFLCKVVSLLKEV 128
Cdd:cd15383   4 VAVTFVLFVLSACSNLAVLWSATRNRRRKLshVRILILHLAAADLLVTFVVMPLDAAWNVTvQWYAGDLACRLLMFLKLF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYlVKFICLSIWGLSLLLALPVLLFRRTVYSSnvSPACYED---MGNNTA 205
Cdd:cd15383  84 AMYSSAFVTVVISLDRHAAILNPLAIGSARRR-NRIMLCAAWGLSALLALPQLFLFHTVTAT--PPVNFTQcatHGSFPA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWR-MLLRILPQSFGFIVPLLIMLFCYGFTL--------RTLFKAHMGQ------------KHRAMRVIFAVVLIFLLCW 264
Cdd:cd15383 161 HWQeTLYNMFTFFCLFLLPLLIMIFCYTRILleisrrmkEKKDSAKNEValrsssdnipkaRMRTLKMTIVIVSSFIVCW 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504683  265 LPYNLVLLADTLMRTQVIQETCERRNHIdraldaTEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15383 241 TPYYLLGLWYWFSPEMLEQTVPESLSHI------LFLFGLLNACLDPLIYGLFTISFRRGL 295
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
50-322 4.61e-13

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 68.16  E-value: 4.61e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKE 127
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATAdLLVGVLVLPLAIIRQLLGyWPLGSHLCDFWISLDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIvhaTRTLTQKRYLVKFI---------CLSIWGLSLLLALPVLLFRRTV----YSSNVSP 194
Cdd:cd15061  81 LLCTASILNLCCISLDRYFAI---TYPLKYRTKRSRRLaitmilavwVISLLITSPPLVGPSWHGRRGLgscyYTYDKGY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  195 ACYEDMGnntanwrmllrilpqsfGFIVPLLIMLFCYgftLRTLFKAHMGQKhrAMRVIFAVVLIFLLCWLPYNLVLLAD 274
Cdd:cd15061 158 RIYSSMG-----------------SFFLPLLLMLFVY---LRIFRVIAKERK--TAKTLAIVVGCFIVCWLPFFIMYLIE 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4504683  275 TLMRTQVIQETcerrnhidraLDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15061 216 PFCDCQFSEAL----------STAFTWLGYFNSVINPFIYAFYNKDFR 253
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
52-322 9.29e-13

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 67.46  E-value: 9.29e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVN 129
Cdd:cd15060   4 TILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVAdLAVAIFVLPLNVAYFLLGkWLFGIHLCQMWLTCDILC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIvHATRTLTQKRYLvKFICLSIWGLSLLLALPVLLfrrTVYSSNVSPACYEDMGNNTANWRM 209
Cdd:cd15060  84 CTASILNLCAIALDRYWAI-HDPINYAQKRTL-KRVLLMIVVVWALSALISVP---PLIGWNDWPENFTETTPCTLTEEK 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  210 LLRILPQSFGFIVPLLIMLFCYGFTLRTLFKahmgqKHRAMRVIFAVVLIFLLCWLPYNLVLladtlmrtqVIQETCERR 289
Cdd:cd15060 159 GYVIYSSSGSFFIPLLIMTIVYVKIFIATSK-----ERRAARTLGIIMGVFVVCWLPFFLMY---------VILPFCETC 224
                       250       260       270
                ....*....|....*....|....*....|...
gi 4504683  290 NHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15060 225 SPSAKVVNFITWLGYVNSALNPVIYTIFNLDFR 257
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
52-325 9.42e-13

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 67.59  E-value: 9.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15978   4 ILLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSdLMLCLFCMPFTLIPNLlKDFIFGSAVCKTATYFMGIS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVH--ATRTLTQKRYLVKFIClSIWGLSLLLALPVLLFrrtvysSNVSPacYEDMGNNTANW 207
Cdd:cd15978  84 VSVSTFNLVAISLERYSAICKplKSRVWQTKSHALKVIA-ATWCLSFTIMLPYPIY------SNLVP--FTRINNSTGNM 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLL---RILPQSFG-------FIVPLLIMLFCYGFTLRTLFKA--HMGQKHRAMRVIFAVVLIFLLCWLPynlVLLADT 275
Cdd:cd15978 155 CRLLwpnDVTQQSWYiflllilFLIPGIVMMTAYGLISLELYRGikFLMAKKRVIRMLIVIVILFFLCWTP---IFSANA 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4504683  276 LMRTQviqetcerRNHIDRALDATEI-----LGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15978 232 WRAFD--------TRSADRLLSGAPIsfihlLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
51-324 1.34e-12

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 67.00  E-value: 1.34e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15067   2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVgSIVMPFSILHEMTGgyWLFGRDWCDVWHSFDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIV----HATRtLTQKRYLVkfICLSIWGLSLLLALPVLLFRRTVYSSNVSPA-CY--EDM 200
Cdd:cd15067  82 LASTASILNLCVISLDRYWAITdpisYPSR-MTKRRALI--MIALVWICSALISFPAIAWWRAVDPGPSPPNqCLftDDS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  201 GnntanwrmlLRILPQSFGFIVPLLIMLFCYGFTLRTLFKahmgqKHRAMRVIFAVVLIFLLCWLPYnlvLLADTLMRTQ 280
Cdd:cd15067 159 G---------YLIFSSCVSFYIPLVVMLFTYYRIYRAAAK-----EQKAAKTLGIVMGVFILCWLPF---FVTNILIGFC 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4504683  281 viQETCErrNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd15067 222 --PSNCV--SNPDILFPLVTWLGYINSGMNPIIYACSSRDFRRA 261
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
53-316 1.37e-12

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 67.45  E-value: 1.37e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVML-VILYSRVGRSVTDVYLLNLALADLLFALTLPIWAA-SKVNG-WIFGTFlCKVVSLLKEVN 129
Cdd:cd15057   5 CILYLLVLLTLLGNALVIAaVLRFRHLRSKVTNYFIVSLAVSDLLVAILVMPWAAvNEVAGyWPFGSF-CDVWVSFDIMC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHA---TRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRtVYSSNVSPACYEDMGNNTAN 206
Cdd:cd15057  84 STASILNLCVISVDRYWAISSPfryERRMTRRRAFIMIAVAWTLSALISFIPVQLGWHR-ADDTSEALALYADPCQCDSS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLRTL-----------------------FKAHMGQKHRAMRVIFAVVLIFLLC 263
Cdd:cd15057 163 LNRTYAISSSLISFYIPVAIMIVTYTRIYRIArrqirriaaleraaqestnpdssLRSSLRRETKALKTLSIIMGVFVCC 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4504683  264 WLPYNLVLLADTLMRTQVIQETCERrnhiDRALDATEILGILHSCLNPLIYAF 316
Cdd:cd15057 243 WLPFFILNCVLPFCDLRTAQFPCVP----DTTFIVFVWLGWANSSLNPIIYAF 291
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
50-322 1.82e-12

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 66.63  E-value: 1.82e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKE 127
Cdd:cd15066   1 LKGFAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMAdMLVALCAMTFNASVEITGrWMFGYFMCDVWNSLDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHA---TRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRT----VYSSNVSPACyEDM 200
Cdd:cd15066  81 YFSTASILHLCCISVDRYYAIVQPleyPSKMTKRRVAIMLANVWISPALISFLPIFLGWYTTeehlQYRKTHPDQC-EFV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  201 GNNTanwrmlLRILPQSFGFIVPLLIMLFCYgftLRTLFKAHmgQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLmrtq 280
Cdd:cd15066 160 VNKI------YALISSSVSFWIPCIVMIFTY---YRIYLEAK--REHKAAKTLGIIMGAFILCWLPFFLWYVTTTL---- 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4504683  281 viqetCERRNHIDRALdaTEIL---GILHSCLNPLIYAFIGQKFR 322
Cdd:cd15066 225 -----CGDACPYPPIL--VSILfwiGYFNSTLNPLIYAYFNRDFR 262
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
50-323 1.83e-12

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 66.74  E-value: 1.83e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAAS--KVNGWIFGTFLCKVVSLLKE 127
Cdd:cd15366   2 FPPTLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYflHRDNWIHGPESCKLFGFIFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPA-CYED--MGNNT 204
Cdd:cd15366  82 TNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFHDELFRDRYNHTfCFEKypMEDWV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 AnWRMLLRILpqsFGFIVPLLIMLFCYGFTLRTL---FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTqV 281
Cdd:cd15366 162 A-WMNLYRVF---VGFLFPWVLMLFSYRGILRAVrgnVSTEQQEKAKIKRLALSLIAIVLLCFAPYHVLLLSRSVVYL-G 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  282 IQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15366 237 KPCDCGFEERVFTAYHVSLALTSLNCVADPILYCLVNEGARS 278
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
51-322 3.50e-12

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 66.06  E-value: 3.50e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15131   3 ITVTCVLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPldLYRLWQYRPWNFGDLLCKLFQFVSES 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAI---VHATRTLTQKRylVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSP-ACYEDMGNNT 204
Cdd:cd15131  83 CTYSTILNITALSVERYFAIcfpLRAKVVVTKRR--VKLVILVLWAVSFLSAGPIFVLVGVEHENGTNPiDTNECKATEY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILP--QSFGFIVPLLIMLFCYGFTLRTLFK----------AHMGQKHR-AMRVIFAVVLIFLLCWLPYNL-- 269
Cdd:cd15131 161 AVRSGLLTIMVwvSSVFFFLPVFCLTVLYSLIGRKLWRrrrenigpnaSHRDKNNRqTVKMLAVVVFAFVLCWLPFHVgr 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504683  270 VLLADTL----MRTQVIQETCERrnhidraldATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15131 241 YLFSKSFeagsLEIALISQYCNL---------VSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
53-325 3.88e-12

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 66.11  E-value: 3.88e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP----IWAASkvNGWIFGTFLCKVVSLLKEV 128
Cdd:cd16003   5 LAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTlinfIYALH--SEWYFGEAYCRFHNFFPIT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRyLVKFICLSIWglsllLALPVLLFRRTVYS-SNVSPA---CYEdMGNNT 204
Cdd:cd16003  83 SVFASIYSMTAIAVDRYMAIIDPLKPRLSAT-ATKVVIGSIW-----ILAFLLAFPQCLYSkTKVMPGrtlCFV-AWPGG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTL------------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLL 272
Cdd:cd16003 156 PDQHFTYHIIVIVLVYCLPLLVMGITYTIVGITLwggeipgdtsdkYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFI 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4504683  273 ADTlmrtqvIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd16003 236 VTG------LYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
49-323 5.91e-12

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 64.98  E-value: 5.91e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLK 126
Cdd:cd15210   1 YFAAVWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISdLLFCAFNLPLAASTFLHQaWIHGETLCRVFPLLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHatRTLTQKRYLVKFICL---SIW--GLSLLLALPVLLFRRTVYSSNVSPACYEDMG 201
Cdd:cd15210  81 YGLVAVSLLTLVLITLNRYILIAH--PSLYPRIYTRRGLALmiaGTWifSFGSFLPLWLGIWGRFGLDPKVCSCSILRDK 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  202 NNTANWRMLLrilpqSFGFIVPLLIMLFCYgftLRTLFKahmgqkhRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQV 281
Cdd:cd15210 159 KGRSPKTFLF-----VFGFVLPCLVIIICY---ARREDR-------RLTRMMLVIFLCFLVCYLPITLVNVFDDEVAPPV 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  282 IqetcerrnHIdraldATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15210 224 L--------HI-----IAYVLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
53-326 6.16e-12

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 65.22  E-value: 6.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRvGRSVTDVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKEVNF 130
Cdd:cd15150   5 LLYTVLFIVGLTMNGLAMRVFFQIP-SKSNFIIFLKNTVISDLLMILTFPfkILSDAKLGSWPLRGFVCQVTSVIFYFTM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATRTLTQKRYL-VKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRM 209
Cdd:cd15150  84 YISILFLGLITIDRYQKTTRPFKTSNPKNLLgAKILSTVIWASMFALSLPNMILTNRQPTPKNVKKCSLLKSEFGLVWHE 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  210 LLRILPQsFGFIVPLLIMLFCYGFTLRTLFKAH--------MGQKHRAMRViFAVVLIFLLCWLPYNLVLLADTLMRTQV 281
Cdd:cd15150 164 IVNYICQ-VIFWVNFLIVIVCYTLITKELYKSYkrtrgvgkVSRKKVNVKV-FIIIAVFFICFVPFHFARIPYTLSQTRD 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4504683  282 IQEtCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLL 326
Cdd:cd15150 242 VFD-CTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLI 285
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
112-269 6.78e-12

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 64.97  E-value: 6.78e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  112 WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYL-VKFICLSIW--GLSLLLALPVLLFRRTVY 188
Cdd:cd15170  67 WPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLyAVIASVFFWvlAFSHCSIVYIVEYHIDSE 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  189 SSNV--SPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVV---LIFLLC 263
Cdd:cd15170 147 NTSVtnNSRCYDNFTPEQLKILLPVRLELFLVLFCIPFLITCFCYINFIRILSSLPHISRQRKQRAIGLAVatlLNFIVC 226

                ....*.
gi 4504683  264 WLPYNL 269
Cdd:cd15170 227 FAPYNI 232
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
112-316 6.93e-12

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 65.14  E-value: 6.93e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  112 WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSiWGLSLLLALPVLLFRRTVYSSN 191
Cdd:cd15197  66 WRAGDFACKVIRYLQVVVTYASTYVLVALSIDRYDAICHPMNFSQSGRQARVLICVA-WILSALFSIPMLIIFEKTGLSN 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  192 VSPACYEDMGNNTAnWRMLLRILPQSFgFIVPLLIMLFCYGFTLRTLFKAHMGQ-------------------------K 246
Cdd:cd15197 145 GEVQCWILWPEPWY-WKVYMTIVAFLV-FFIPATIISICYIIIVRTIWKKSKIQvtinkaglhdgssrrsssrgiipraK 222
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  247 HRAMRVIFAVVLIFLLCWLPYNLVLLADTLmrtQVIQETCERRnhidRALDATEILGILHSCLNPLIYAF 316
Cdd:cd15197 223 IKTIKMTFVIVTVFIICWSPYFVFDLLDVF---GLLPRSKTKI----AAATFIQSLAPLNSAINPLIYCL 285
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
51-325 7.33e-12

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 65.15  E-value: 7.33e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAAS--KVNGWIFGTFLCKVVSLLKE 127
Cdd:cd15394   3 IIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSdMLMCATCVPLTLAYafEPRGWVFGRFMCYFVFLMQP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRyLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANW 207
Cdd:cd15394  83 VTVYVSVFTLTAIAVDRYYVTVYPLRRRISRR-TCAYIVAAIWLLSCGLALPAAAHTYYVEFKGLDFSICEEFWFGQEKQ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFGFIVPLLIMLFCY---GFTLRT-LFKAHMGQ---------KHRAMRVIFAVVLIFLLCWLPYNLVllad 274
Cdd:cd15394 162 RLAYACSTLLITYVLPLLAISLSYlriSVKLRNrVVPGSMTQsqaewdrarRRKTFRLLVVVVVAFAICWLPLHIF---- 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 4504683  275 TLMRTqvIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15394 238 NVIRD--IDIDLIDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFRGEL 286
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
51-322 7.92e-12

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 64.82  E-value: 7.92e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEV 128
Cdd:cd15062   3 VGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVAdLLLSFTVLPFSATLEVLGyWAFGRIFCDVWAAVDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATR---TLTQKRYLVkfICLSIWGLSLLLALPVLLFRRtvyssNVSPACYEDMGNNTA 205
Cdd:cd15062  83 CCTASIMSLCVISVDRYIGVRYPLNyptIVTARRATV--ALLIVWVLSLVISIGPLLGWK-----EPAPADEQACGVNEE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILPQsfgFIVPLLIMLFCYGFTLRTLFKahMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQET 285
Cdd:cd15062 156 PGYVLFSSLGS---FYLPLAIILVMYCRVYVVAFK--FSREKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLFSTLKPPEP 230
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4504683  286 cerrnhidrALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15062 231 ---------VFKVVFWLGYFNSCLNPIIYPCSSREFK 258
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
52-325 1.12e-11

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 64.91  E-value: 1.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASK-VNGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15980   4 IASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVgIFCMPTTLLDNiIAGWPFGSTVCKMSGMVQGIS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATR-TLTQKRYLVkfICLSIW----------GLSLLLALPVLLFRRTVYSSNVSPA--C 196
Cdd:cd15980  84 VSASVFTLVAIAVDRFRCIVYPFKqKLTISTAVV--IIVIIWvlaiaimcpsAVMLHVQEEKNYRVVLGSQNKTSPVywC 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  197 YEDMGNntANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMG---------------QKHRAMRVIFAVVLIFL 261
Cdd:cd15980 162 REDWPN--QEMRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPhtgkhnqeqrhvvsrKKQKVIKMLLIVALLFI 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504683  262 LCWLP-YNLVLLAD----TLMRTQVIQETCERRNHidraldateILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15980 240 LSWLPlWTLMMLSDyanlSPNQLQIINIYIYPFAH---------WLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
49-325 1.24e-11

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 64.38  E-value: 1.24e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVmLVILYSRVGRSVTD--VYLLNLALADLLFALTLPIWAASKV-NGWIFGTFLCKVVSLL 125
Cdd:cd14983   1 QLSLMVYVLTILLGLPSNLLA-LYAFVNRARLRLTPnvIYMINLCLSDLVFILSLPIKIVEALsSAWTLPAVLCPLYNLA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  126 KEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVK-FICLSIWGLSLLLALPVLLFRRTVYSSNV------SPACYE 198
Cdd:cd14983  80 HFSTLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYScLVCVAIWALVIFHVTLVFILETSGGTLDIntpvgnSSTCYE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  199 DMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMG--QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTl 276
Cdd:cd14983 160 NFTPEQLALLAPVRLELSLVLFFLPLAITAFCYVRCIRILVRSRLHerRKRRAVRVAVSTLLTFVVCFGPYNISHVVGF- 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4504683  277 mrtqVIQETCERRNhidRALdateILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14983 239 ----VRHESVWWRK---LAL----LTSTCNAFLDPLIFYFLSSSMERGF 276
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
53-325 1.28e-11

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 64.42  E-value: 1.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVmLVILYSRVGRSVTDVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKEVNF 130
Cdd:cd15151   5 VLYTVLFLVGLILNSVA-AWIFFHIPSTSTFIVYLKNTLVADLIMTLMLPfkILSDSGLGPWQLRAFVCRFSAVVFYITM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHA-TRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRM 209
Cdd:cd15151  84 YISIILLGLISFDRYLKIVRPfGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKPATPISVKKCASLKSPLGLKWHE 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  210 LLRILPQsFGFIVPLLIMLFCYGFTLRTLFKAHMGQK-------HRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVI 282
Cdd:cd15151 164 VVNYICQ-FIFWGVFALMVLFYTIISKKVYESYKKSRskdnkasKKTKAKVFIIVAVFFVCFAPFHFVRVPYTLSQTGKI 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  283 QEtCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15151 243 TD-CQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQRL 284
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
52-322 1.70e-11

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 63.67  E-value: 1.70e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKV-NGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15063   4 LLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVgTLVLPFSAVNEVlDVWIFGHTWCQIWLAVDVWM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATR---TLTQKRylVKFICLSIWglsllLALPVLLFRRTVYSSNVSPACYEDMGNNTAN 206
Cdd:cd15063  84 CTASILNLCAISLDRYLAITRPIRypsLMSTKR--AKCLIAGVW-----VLSFVICFPPLVGWNDGKDGIMDYSGSSSLP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLL------RILPQSFGFIVPLLIMLFCYGFTLRTlfkAHMGQKhrAMRVIFAVVLIFLLCWLPYNLVLLadtlmrtq 280
Cdd:cd15063 157 CTCELtngrgyVIYSALGSFYIPMLVMLFFYFRIYRA---ARMETK--AAKTVAIIVGCFIFCWLPFFTVYL-------- 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  281 vIQETCErrNHIDRALDATEI-LGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15063 224 -VRAFCE--DCIPPLLFSVFFwLGYCNSALNPCIYALFSRDFR 263
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
53-321 2.21e-11

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 63.66  E-value: 2.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTdVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKEVNF 130
Cdd:cd15969   5 VLYLIIFIGSILLNGLAVWIFFHIRNKTSFI-FYLKNIVIADLLMTLTFPfkIIQDSGLGPWNFNFFLCRYTSVLFYASM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATRtlTQKRYLVKF---ICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANW 207
Cdd:cd15969  84 YTSIVFLGLISLDRYLKVVKPFG--DSRMYSITFtkvLSACVWLIMAFLSLPNIILTNGQPTEDNIHDCSKLKSPLGVKW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFgFIVPLLIMLFCYGFTLRTL------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQV 281
Cdd:cd15969 162 HTAVSYINICI-FVAVLVILIVCYISISRYIyksskqFISSSSRTRKHNQSIRVVVAVFFVCFLPYHLCRIPFTFSQLDK 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4504683  282 IQEtCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKF 321
Cdd:cd15969 241 ILD-CTIKTILYYCKEATLFLSACNVCLDPIIYFFMCRSF 279
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
50-323 2.24e-11

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 63.63  E-value: 2.24e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15200   2 FLAPVLGIEFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNevWRFGATACQVNLFMLS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRY-LVKFICLSIWGlsLLLALPVLLFRRTVYSSNVSPACYEDMGNNTA- 205
Cdd:cd15200  82 MNRTASIVFLTAIALNRYLKVVHPHHQLSKASVgCAAKVAAGLWI--LILLLNIHLLLLDHVQSNSTCLSYDHGTDPSAs 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 -NWRMLLRILPqsfgFIVPLLIMLFCYGFTLRTLFKAHMGQK---HRAMRVIFAVVLIFLLCWLPyNLVLLADTLMRTQV 281
Cdd:cd15200 160 dRWHRILFFLE----FFLPLGIILFCIFSIILTLKQRKLAKQagpQRAVKVLAVIVLVYTVCFLP-SILFALASLVAFKV 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4504683  282 IQetCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15200 235 SQ--CRSLDLCTQLFHGSLAFTYLNSALDPVLYCFSSPSFLN 274
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
112-316 2.69e-11

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 63.53  E-value: 2.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  112 WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKF-ICLSIWGLSLLLALPVLLFRRTVYSS 190
Cdd:cd15201  66 WKFGDIPCRIVLFMLAMNRAGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAiIACGLWLLTIAMTVYLLTKKHLFPRG 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  191 NVSpAC----YEDMGNNTANWRMLLRILPqsfgFIVPLLIMLFCYGFTLRTLFKAHMGQK---HRAMRVIFAVVLIFLLC 263
Cdd:cd15201 146 NAT-QCesfnICTGTDSSSNWHEAMFLLE----FFLPLAIILYCSVRIIWQLRGRQLDRHakiKRAVQFIMVVAIVFIIC 220
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 4504683  264 WLPYNLVLLAdTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAF 316
Cdd:cd15201 221 FLPSNVTRIA-IWILKHTSNEDCQYYRSVDLAFYITISFTYFNSMLDPVVYYF 272
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
53-324 2.76e-11

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 63.32  E-value: 2.76e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPI--WAASKVNGWIFGTFLCKVVSLLKEVNF 130
Cdd:cd16004   5 IAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAfnFVYASHNDWYFGLEFCRFQNFFPITAM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATRTLTQKRYlVKFICLSIWgLSLLLALPVLLFRRTVYSSNVSPACY----EDMGNNTan 206
Cdd:cd16004  85 FVSIYSMTAIAADRYMAIIHPFKPRLSAGS-TKVVIAGIW-LVALALAFPQCFYSTVTMDQGRTKCIvawpGDSGGKH-- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 wRMLLRILPQSFGFIVPLLIMLFCYGFTLRTL-------------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLA 273
Cdd:cd16004 161 -QLTYHLAVIVLIYLLPLAVMFVTYSIIGITLwrsavpghqahgaYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFIL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 4504683  274 DTLmrtqviQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd16004 240 GSF------NEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSG 284
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
49-322 2.81e-11

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 63.36  E-value: 2.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVN-GWIFGTFLCKVVSLLKE 127
Cdd:cd15079   1 YLLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYeGWALGPLGCQIYAFLGS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVH--ATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSpACYEDMGNNTA 205
Cdd:cd15079  81 LSGIGSIWTNAAIAYDRYNVIVKplNGNPLTRGKALLLILFIWLYALPWALLPLLFGWGRYVPEGFLT-SCSFDYLTRDW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILpQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRA--MRVI---------------------FAVVLIFLL 262
Cdd:cd15079 160 NTRSFVATI-FVFAYVIPLIIIIYCYSFIVKAVFAHEKALREQAkkMNVVslrsnadankqsaeiriakvaLTNVFLWFI 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504683  263 CWLPYNLVLLADTLMRTQVIqetcerrnhidraldaTEILGIL-------HSCLNPLIYAFIGQKFR 322
Cdd:cd15079 239 AWTPYAVVALIGAFGNQSLL----------------TPLVSMIpalfaktAACYNPIVYAISHPKYR 289
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
52-324 3.01e-11

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 63.21  E-value: 3.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP--IWAASKVNGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15000   3 SSMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPwmFLVHDFFQNYVLGSVGCKLEGFLEGSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSiWGLSLLLALPVLLFRR---TVYSSNVSPACYEDMGNNTAN 206
Cdd:cd15000  83 LLASVLALCAVSYDRLTAIVLPSEARLTKRGAKIVIVIT-WIVGLLLALPLAIYRSyreRQWKNFLETYCAENTQVLPIY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILpqsfgFIVPLLIMLFCYG-----------FTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYN-LVLLAD 274
Cdd:cd15000 162 WHVIITVL-----VWLPLGIMLICYSaifwkldkyerRVLRREHPSVVRYKKKAAKTLFIVLITFVVCRIPFTaLIFYRY 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 4504683  275 TLMRTQVIQETCERRNHIdrALDATEILGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd15000 237 KLVPNDNTQNSVSGSFHI--LWFASKYLMFLNAAVNPLIYGFTNENFRKA 284
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
50-322 3.07e-11

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 63.12  E-value: 3.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSR----------VGRSVTDVyllnlaladLLFALTLPIWAASKVNG-WIFGTFL 118
Cdd:cd15064   2 LISVLLSLIILATILGNALVIAAILLTRklhtpanyliASLAVADL---------LVAVLVMPLSAVYELTGrWILGQVL 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  119 CKVVSLLKEVNFYSGILLLACISVDRYLAI---VHATRTLTQKRYLVKFIClsIWGLSLLLALPVLLFRRTVYSsnvspa 195
Cdd:cd15064  73 CDIWISLDVTCCTASILHLCVIALDRYWAItdaVEYAHKRTPKRAAVMIAL--VWTLSICISLPPLFGWRTPDS------ 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  196 cyEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGftlrTLFKAhMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADT 275
Cdd:cd15064 145 --EDPSECLISQDIGYTIFSTFGAFYIPLLLMLILYW----KIYRA-AARERKAAKTLGIILGAFIVCWLPFFLVALIVP 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4504683  276 LmrtqviqetCErRNHIDRALDATEI-LGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15064 218 L---------CS-HCWIPLALKSFFLwLGYFNSLINPLIYTFFNKDFR 255
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
112-325 4.49e-11

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 62.96  E-value: 4.49e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  112 WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATR---TLTQKRYLVkFICLSiWGLSLLLALPVLLFRRTVY 188
Cdd:cd15055  66 WYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLyptKITIRRVKI-CICLC-WFVSALYSSVLLYDNLNQP 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  189 SSNVSPACYED---MGNNTanWRMLLRILPqsfgFIVPLLIMLFCY--------------------GFTLRTLFKAHMGQ 245
Cdd:cd15055 144 GLIRYNSCYGEcvvVVNFI--WGVVDLVLT----FILPCTVMIVLYmrifvvarsqarairshtaqVSLEGSSKKVSKKS 217
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  246 KHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIqetcerrnhidrALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15055 218 ERKAAKTLGIVVGVFLLCWLPYYIVSLVDPYISTPSS------------VFDVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
49-321 8.12e-11

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 61.89  E-value: 8.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWiFGTFLCKVVSLLKEV 128
Cdd:cd15164   1 LIQLIIYIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPFVLYFLKHSW-PDDELCLVLQSIYFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHA--TRTLTQKRYLVkFICLSIWglSLLLALPVLLFRRTVYSSNVspaCYEDmGNNTAN 206
Cdd:cd15164  80 NRYMSIYIITAIAVDRYIAIKYPlkAKSLRSPRKAA-LTCGLLW--VLVIISVSLRLAWEEQEENF---CFGK-TSTRPS 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILpqsFGFIVPLLIMLFCYGFTLRTLFKAHMGQKH------RAMRVIFAVVLIFLLCWLPYNLVLLADTLMrtQ 280
Cdd:cd15164 153 KRTLIFSL---LGFFIPLIILSFCSIQVIRSLKKKKKTNPHeekliqKAIYIVSANLIVFIVCFLPLHIGLLVRFVM--E 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4504683  281 VIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKF 321
Cdd:cd15164 228 SNKASCSLIQNIRNFIYVASCLANANCCLDAICYYFVAKEF 268
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
51-322 8.83e-11

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 61.96  E-value: 8.83e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT------LPIWAASKvngWIFGTFLCKVVSL 124
Cdd:cd15134   3 ITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILglpfelYTIWQQYP---WVFGEVFCKLRAF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  125 LKEVNFYSGILLLACISVDRYLAIVHATR--TLTQKRYLVKFICLsIWGLSLLLALPVLLFRRTVYSSN--VSPACYED- 199
Cdd:cd15134  80 LSEMSSYASVLTITAFSVERYLAICHPLRshTMSKLSRAIRIIIA-IWIIAFVCALPFAIQTRIVYLEYppTSGEALEEs 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  200 ----MGNNTANWRMLLrILPQSFGFIVPLLIMLFCY---GFTLR--TLFKAHMGQKHRA----------MRVIFAVVLIF 260
Cdd:cd15134 159 afcaMLNEIPPITPVF-QLSTFLFFIIPMIAIIVLYvliGLQLRrsTLLRRGQRSVSGGrrssqsrrtvLRMLVAVVVAF 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504683  261 LLCWLPYNlvllADTLMrTQVIQETCERRNHIDRALdaTEILGILH---SCLNPLIYAFIGQKFR 322
Cdd:cd15134 238 FICWAPFH----AQRLL-TVYAKNMTPPYLFINRIL--FYISGVLYyvsSTVNPILYNVMSAKYR 295
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-322 9.34e-11

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 61.69  E-value: 9.34e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLKEV 128
Cdd:cd14999   1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFlKKWYFGDVGCRLLFSLDFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPA----CYEDMGNNt 204
Cdd:cd14999  81 TMHASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGskriCLPTWSEE- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 aNWRMLLRILpQSFGFIVPLLIMLFCYGFTLRTL---------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLAdt 275
Cdd:cd14999 160 -SYKVYLTLL-FSTSIVIPGLVIGYLYIRLARKYwlsqaaasnSSRKRLPKQKVLKMIFTIVLVFWACFLPFWIWQLL-- 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 4504683  276 lmrTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd14999 236 ---YLYSPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYK 279
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
50-322 1.74e-10

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 60.96  E-value: 1.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15199   2 AYASLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGnrWSLGGGTCKALLFMLS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHAT-RTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTAN 206
Cdd:cd15199  82 LSRGVSIAFLTAVALDRYFRVVHPRgKKNSLSLQAAPYISFLVWLLLVGLTIPTLLASQPKNFTECNSFSPKDDEDFSDT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPqsfgFIVPLLIMLFCYGFTLRTLFKAHMGQK-----HRAMRVIFAVVLIFLLCWLPynlVLLADTLMRTQV 281
Cdd:cd15199 162 WQEAVFFLQ----FLLPFGLIVFCTVRIIRRLKKRLRDVGkqpklQRAMALVTSVVVVFGFCFLP---CFLARVLMLIFQ 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4504683  282 IQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15199 235 NKESCNALNIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
43-322 2.24e-10

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 60.71  E-value: 2.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   43 SLEINKYFVVIIYALVfLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCK 120
Cdd:cd15321   2 SVQATAAIAAAITFLI-LFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAAdILVATLIIPFSLANELMGyWYFRKTWCE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  121 VVSLLKEVNFYSGILLLACISVDRYLAIVHATR---TLTQKRylVKFICLSIWGLSLLLALPVLLFR-RTVYSSNVSPAC 196
Cdd:cd15321  81 IYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEynsKRTPRR--IKCIILIVWLIAAVISLPPLIYKgKQKDEQGGLPQC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  197 YEdmgnNTANWrmllRILPQSFG-FIVPLLIMLFCYgftLRTLFKAHMGQKhRAMRVIFAVVLIFLLCWLPYNLvlladt 275
Cdd:cd15321 159 KL----NEEAW----YILSSSIGsFFAPCLIMILVY---LRIYLIAKNREK-RFTFVLAVVIGVFVLCWFPFFF------ 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4504683  276 lmrTQVIQETCERRNHIDRALDATEI-LGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15321 221 ---SYSLGAICPELCKVPHSLFQFFFwIGYCNSSLNPVIYTIFNQDFR 265
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
52-322 2.40e-10

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 60.87  E-value: 2.40e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVN-GWIFGTFLCKVVSLLKEVN 129
Cdd:cd15208   4 IALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLAdFLVIIICLPATLLVDVTeTWFFGQVLCKIIPYLQTVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATR-TLTQKRylVKFICLSIWGLSLLLA---LPVLLFRRTVYSSNVSP---ACYEDMGN 202
Cdd:cd15208  84 VSVSVLTLSCIALDRWYAICHPLMfKSTAKR--ARVSILIIWIVSLLIMipqAIVMECSRVVPLANKTIlltVCDERWSD 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  203 NT--ANWRMLLRILPqsfgFIVPLLIMLFCYGFTLRTLF----------------KAHMGQKHRAMRVI----------F 254
Cdd:cd15208 162 SIyqKVYHICFFLVT----YLLPLCLMILAYFQIFRKLWcrqipgtssvvqrkwnKPRKSAVAAEEKQLrsrrktakmlI 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504683  255 AVVLIFLLCWLPYNLVlladTLMRTQVIQETCERRNHIDRALDAtEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15208 238 VVVIMFAICYLPVHLL----NILRYVFGLFTVDRETIYAWFLFS-HWLVYANSAINPIIYNFMSGKFR 300
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
49-322 2.60e-10

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 60.41  E-value: 2.60e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTL--PIWAASKVNG-WIFGTFLCKVVSLL 125
Cdd:cd15337   1 YLIGIYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNgfPLKTISSFNKkWIWGKVACELYGFA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  126 KEVNFYSGILLLACISVDRYLAIVH---ATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTV----------YSSNv 192
Cdd:cd15337  81 GGIFGFMSITTLAAISIDRYLVIAKpleAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPegfqtsctfdYLSR- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  193 spacyeDMGNNTANWRMLLrilpqsFGFIVPLLIMLFCYGFTLRTLFKAH---------MGQKHRAM------------R 251
Cdd:cd15337 160 ------DLNNRLFILGLFI------FGFLCPLLIIIFCYVNIIRAVRNHEkemtqtaksGMGKDTEKndarkkaeiriaK 227
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504683  252 VIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETcerrnhidraldATEILGIL---HSCLNPLIYAFIGQKFR 322
Cdd:cd15337 228 VAIILISLFLLSWTPYAVVALLGQFGPAYWITPY------------VSELPVMFakaSAIYNPIIYALSHPKFR 289
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
54-322 2.64e-10

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 60.34  E-value: 2.64e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVNFY 131
Cdd:cd15323   6 VVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASAdILVATLVMPFSLANELMGyWYFGQVWCNIYLALDVLFCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  132 SGILLLACISVDRYLAIVHATR-TLTQKRYLVKFICLSIW--GLSLLLALPVLLFRRTVysSNVSPACyedmGNNTANWr 208
Cdd:cd15323  86 SSIVHLCAISLDRYWSVTQAVEyNLKRTPRRVKAIIVTVWliSAVISFPPLISMYRDPE--GDVYPQC----KLNDETW- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  209 mllRILPQSFG-FIVPLLIMLFCYGftlrTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYnlvLLADTLMrtQVIQETCE 287
Cdd:cd15323 159 ---YILSSCIGsFFAPCLIMILVYI----RIYRVAKAREKRFTFVLAVVMGVFVVCWFPF---FFSYSLY--GICREACE 226
                       250       260       270
                ....*....|....*....|....*....|....*
gi 4504683  288 RRNHIDRALdatEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15323 227 VPEPLFKFF---FWIGYCNSSLNPVIYTIFNQDFR 258
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
50-314 2.98e-10

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 60.54  E-value: 2.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKE 127
Cdd:cd15058   2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMgLLVVPLGATIVVTGkWQLGNFWCELWTSVDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIvhaTRTLTQKRYLVK----FICLSIW---GLSLLLALPVLLFRRTVYSSNVspaCYEDM 200
Cdd:cd15058  82 LCVTASIETLCVIAVDRYIAI---TRPLRYQVLLTKrrarVIVCVVWivsALVSFVPIMNQWWRANDPEAND---CYQDP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  201 GNNTANWRMLLRILPQSFGFIVPLLIMLFCYG---------------------------FTLRTLFKAHMG--------- 244
Cdd:cd15058 156 TCCDFRTNMAYAIASSVVSFYIPLLIMIFVYArvfliatrqlqlidkrrlrfqsecpapQTTSPEGKRSSGrrpsrltvv 235
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  245 QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQEtcerrnhIDRALDAteiLGILHSCLNPLIY 314
Cdd:cd15058 236 KEHKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLPPGE-------VFLLLNW---LGYINSGLNPIIY 295
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
49-323 4.17e-10

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 59.92  E-value: 4.17e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLAL-ADLLFALTLPIWAAS-KVNGWIFGTFLCKVVSLLK 126
Cdd:cd15977   1 YVNTILSCVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALgDLLYILIAIPINVIKlIAEDWPFGVHVCKLYPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLS-IWGLSLLLALPVLLFRRTV---YSSNVSPACYEDMgN 202
Cdd:cd15977  81 KASVGITVLSLCALSIDRYRAVASWSRIRGIGIPVWKAVEVTlIWAVAIIVAVPEAIAFDMVeidYRGQTLLVCMLPM-E 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  203 NTANWRMLLRILPQ----SFGFIVPLLIMLFCYGFT----------LRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYN 268
Cdd:cd15977 160 QTSSFMRFYQDVKDwwlfGFYFCLPLACTGVFYTLMscemlsikngMRIALNDHMKQRREVAKTVFCLVVIFALCWLPLH 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4504683  269 LVLLADTLMRTQVIQETCERRNHIdRALDATEI-LGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15977 240 LSRILKKTIYDVKDPQRCELLSFL-LVMDYTGInMASLNSCINPVALYFVSRKFKN 294
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
60-322 4.26e-10

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 59.52  E-value: 4.26e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   60 LLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVNFYSGILLL 137
Cdd:cd15326  12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIAdLLLSFTVLPFSATLEILGyWVFGRIFCDIWAAVDVLCCTASILSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  138 ACISVDRYLAIVHATR---TLTQKRYLVKFicLSIWGLSlllalpvllfrrTVYSSNVSPACYEDMGNNTANWRMLLRIL 214
Cdd:cd15326  92 CAISIDRYIGVRHSLQyptIVTRKRAILAL--LGVWVLS------------TVISIGPLLGWKEPAPPDDKVCEITEEPF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  215 PQSF----GFIVPLLIMLFCYGFTLRTLFKahMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERrn 290
Cdd:cd15326 158 YALFsslgSFYIPLIVILVMYCRVYIVALK--FSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSHLKPPETLFK-- 233
                       250       260       270
                ....*....|....*....|....*....|..
gi 4504683  291 hidraldATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15326 234 -------IIFWLGYFNSCLNPIIYPCSSKEFK 258
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
53-322 5.84e-10

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 59.14  E-value: 5.84e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVNF 130
Cdd:cd15325   5 VILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVAdLLLTSTVLPFSAIFEILGyWAFGRVFCNIWAAVDVLCC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATR---TLTQKRYLVKFIClsIWGLSLLLAL-PVLLFRRTVYSSNVSPACYEDMGnntan 206
Cdd:cd15325  85 TASIMSLCIISIDRYIGVSYPLRypsIMTERRGLLALLC--VWVLSLVISIgPLFGWKEPAPEDETICQITEEPG----- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 wrmllRILPQSFG-FIVPLLIMLFCYGFTLRTLFKahMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQviqet 285
Cdd:cd15325 158 -----YALFSALGsFYLPLAIILVMYCRVYVVALK--FSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAY----- 225
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4504683  286 cerrNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15325 226 ----KPSDTVFKITFWLGYFNSCINPIIYPCSSQEFK 258
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
52-325 6.35e-10

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 59.38  E-value: 6.35e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIY---ALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLK 126
Cdd:cd15317   1 VIIYivlVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLgLCVMPFSMIRTVETcWYFGDLFCKFHTGLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSI-WGLSLLLALPVLLF-----RRTVYSSNVS--PACYE 198
Cdd:cd15317  81 LLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIgWLVPGIYTFGLIYTgandeGLEEYSSEIScvGGCQL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  199 DMGNntaNWrmllrILPQSFGFIVPLLIMLFCYG---------------------FTLRTLFKAHMGQKHRAMRVIFAVV 257
Cdd:cd15317 161 LFNK---IW-----VLLDFLTFFIPCLIMIGLYAkiflvarrqarkiqnmedkfrSSEENSSKASASRERKAAKTLAIVM 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504683  258 LIFLLCWLPYNLVLLADTLMrtQVIQETCerrnhidrALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15317 233 GIFLFCWLPYFIDTIVDEYS--NFITPAI--------VFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
49-323 7.31e-10

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 59.08  E-value: 7.31e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG--WIFGTFLCKVVSLL 125
Cdd:cd15308   1 AAALVGGVLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLaLLVLPLYVYSEFQGgvWTLSPVLCDALMTM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  126 KEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLS-IWGLSLLLALPVLLFRRTVYSSNVSPACYEDmgNNT 204
Cdd:cd15308  81 DVMLCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISaTWILSFAVASPVIFGLNNVPNRDPAVCKLED--NNY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLrilpqsfGFIVPLLIMLFCYGFTLRTLfkahmGQKHRAMRVIFAVVLIFLLCWLPYNLVlladtlmrtQVIQE 284
Cdd:cd15308 159 VVYSSVC-------SFFIPCPVMLVLYCAMFRGL-----GRERKAMRVLPVVVGAFLFCWTPFFVV---------HITRA 217
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4504683  285 TCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15308 218 LCESCSIPPQLISIVTWLGYVNSALNPVIYTVFNAEFRN 256
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
53-314 8.44e-10

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 59.14  E-value: 8.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVNF 130
Cdd:cd15958   5 LLMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMgLLVVPFGATLVVRGrWLYGSFFCELWTSVDVLCV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATR---TLTQKRylVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANW 207
Cdd:cd15958  85 TASIETLCVIAIDRYLAITSPFRyqsLLTRAR--AKGIVCTVWAISALVSFLPIMMHWWRDEDDQALKCYEDPGCCDFVT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFGFIVPLLIMLFCY-----------------------------GFTLRTLFKAHMGQKHRAMRVIFAVVL 258
Cdd:cd15958 163 NRAYAIASSIISFYIPLLIMIFVYlrvyreakkqikkidkcegrfhntltglgRKCKRRPSRILALREQKALKTLGIIMG 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4504683  259 IFLLCWLPYNLVLLADTLMRTQViqetcerrnhIDRALDATEILGILHSCLNPLIY 314
Cdd:cd15958 243 VFTLCWLPFFLVNVVNVFNRELV----------PDWLFVFFNWLGYANSAFNPIIY 288
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
58-322 9.09e-10

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 58.84  E-value: 9.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   58 VFLLSLLGNSLVMLVILYSRVGRSVTD-VYLLNLALADLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLKEVNFYSGIL 135
Cdd:cd15330  10 LILCAIFGNACVVAAIALERSLQNVANyLIGSLAVTDLMVSVLVLPMAALYQVlNKWTLGQVTCDLFIALDVLCCTSSIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  136 LLACISVDRYLAIVHATRTLTQKRYLVKFICLSI-WGLSLLLALPVLLFRRTVYSSNVSPACY--EDMGNNtanwrmllr 212
Cdd:cd15330  90 HLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLtWLIGFSISIPPMLGWRTPEDRSDPDACTisKDPGYT--------- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  213 iLPQSFG-FIVPLLIMLFCYGftlrTLFKAhMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLadtlmrtqvIQETCERRNH 291
Cdd:cd15330 161 -IYSTFGaFYIPLILMLVLYG----RIFKA-AARERKTVKTLGIIMGTFILCWLPFFIVAL---------VLPFCESTCH 225
                       250       260       270
                ....*....|....*....|....*....|..
gi 4504683  292 IDRALDAT-EILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15330 226 MPELLGAIiNWLGYSNSLLNPIIYAYFNKDFQ 257
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
114-323 1.17e-09

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 58.72  E-value: 1.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  114 FGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFI-CLSIW------------GLSLLLALPV 180
Cdd:cd15975  73 FGVFLCKLVPFLQKASVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIeIFSIWvlsfilaipeaiGFVMVPFEYN 152
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  181 LLFRRTVYSSNVSPacYEDMGNNTANWRMLlrilpqSFGFIVPLLIMLFCYGF-----------TLRTLFKAHMGQKHRA 249
Cdd:cd15975 153 GEQYRTCMLNATTK--FMNFYVDAKDWWLF------GFYFCVPLACTAIFYTLmtcemlnrrkgSLRIALSEHLKQRREV 224
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504683  250 MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIdRALDATEI-LGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15975 225 AKTVFCLVVIFALCWFPLHLSRILKKTVYNENDPRRCELLSFL-LVMDYISInLATMNSCINPIALYFVSKKFKN 298
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-267 1.50e-09

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 58.44  E-value: 1.50e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT-LPI---WAASKVNGWIFGTFLCKVVSLL 125
Cdd:cd15204   2 VLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFcLPFemdYYVVRQRSWTHGDVLCAVVNYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  126 KEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLsIWGLSLLLALPVLLFRRTVYssnvspacYEDMGNNTA 205
Cdd:cd15204  82 RTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIAL-VWVVSLLLAIPSAVYSKTTP--------YANQGKIFC 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 N--WRMLLRILPQSF-------GFIVPLLIMLFCYGFTLRTL-FKAHMGQ-----------KHRAMRVIFAVVLIFLLCW 264
Cdd:cd15204 153 GqiWPVDQQAYYKAYylflfvlEFVLPVLIMTLCYLRIVRKVwFRRVPGQqteqirrrlrrRRRKVRLLVVILTAFVLCW 232

                ...
gi 4504683  265 LPY 267
Cdd:cd15204 233 APY 235
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
50-322 3.87e-09

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 56.77  E-value: 3.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKE 127
Cdd:cd15404   2 ILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITtrWIFGDAFCRVSAMFFW 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVkFICLSiWGLSLLLALPVLLFRRTVYSSNVSPACYedMGNNTANW 207
Cdd:cd15404  82 LFVMEGVAILLIISIDRFLIIVQKQDKLNPYRAKV-LIAVS-WAVSFCVAFPLAVGSPDLQIPSRAPQCV--FGYTTNPG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFGFIVPLLIMLFCYGFTLRTLfkahMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRtqviqetce 287
Cdd:cd15404 158 YQAYVILIMLIFFFIPFMVMLYSFMGILNTV----RSFKTRAFTTILILFIVFTVCWAPFTTYSLVATFNS--------- 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4504683  288 rrnHIDRALDATEI------LGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15404 225 ---HFYHKHNFFEIstwllwLCYLKSALNPLIYYWRIKKFR 262
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-322 4.57e-09

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 56.88  E-value: 4.57e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVY----LLNLALADLLFALTLPIWAASKV---NGWIFGTFLCKVV 122
Cdd:cd15130   2 LVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVryhlGSLALSDLLILLLAMPVELYNFIwvhHPWAFGDAGCRGY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  123 SLLKEVNFYSGILLLACISVDRYLAIVHA--TRTLTQKRYLVKFICLsIWGLSLLLALPVLLFRRTVYSSNVSP-----A 195
Cdd:cd15130  82 YFLRDACTYATALNVASLSVERYLAICHPfkAKTLMSRSRTKKFISA-IWLASALLAIPMLFTMGLQNESDDGThpgglV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  196 CYEDMGNNTANWRMLLRILpqsFGFIVPLLIMLFCYGFTLRTLFKAhmgqKHRAMRVIFAVVLIFLLCWLPYNlvllADT 275
Cdd:cd15130 161 CTPIVDTATLKVVIQVNTF---MSFLFPMLVTSILNTVIANKLVQA----LRRGVLVLRAVVIAFVVCWLPYH----VRR 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4504683  276 LMRTQVIQE--TCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15130 230 LMFCYISDEqwTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFR 278
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
49-323 4.72e-09

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 56.87  E-value: 4.72e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVmLVILYSRVGRSVTDVY---------LLNLALADLLFALTLPIWAASKVNGWIFgtFLC 119
Cdd:cd14978   1 VLYGYVLPVICIFGIIGNILN-LVVLTRKSMRSSTNVYlaalavsdiLVLLSALPLFLLPYIADYSSSFLSYFYA--YFL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  120 KVVSLLKEVNFYSGILLLACISVDRYLAIVHA--TRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACY 197
Cdd:cd14978  78 PYIYPLANTFQTASVWLTVALTVERYIAVCHPlkARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  198 EDMGNNTANWRMLL----RILPQSFGFIVPLLIMLFCYGFTLRTLFKA----------------HMGQKHRAMRVIFAVV 257
Cdd:cd14978 158 YVIPTLLRQNETYLlkyyFWLYAIFVVLLPFILLLILNILLIRALRKSkkrrrllrrrrrllsrSQRRERRTTIMLIAVV 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504683  258 LIFLLCWLPYNLVLLADTLMrtqviqETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd14978 238 IVFLICNLPAGILNILEAIF------GESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRR 297
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
218-322 4.94e-09

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 56.55  E-value: 4.94e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  218 FGFIVPLLIMLFCYGFTLRTLfkahmGQKHRAMRVIFAVVLIFLLCWLPYNLvlladtlmrTQVIQETCERRNH--IDRA 295
Cdd:cd15052 167 VAFFIPLLIMVVTYALTIRLL-----SNEQKASKVLGIVFAVFVICWCPFFI---------TNILTGLCEECNCriSPWL 232
                        90       100
                ....*....|....*....|....*..
gi 4504683  296 LDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15052 233 LSVFVWLGYVSSTINPIIYTIFNKTFR 259
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
114-323 5.46e-09

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 56.76  E-value: 5.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  114 FGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRtltqkrylVKFICLSIWGLSLLLALPVLLFRRTVYSS--- 190
Cdd:cd15128  73 FGQFLCKLVPFIQKASVGITVLNLCALSVDRYRAVASWSR--------IQGIGIPMWTAVEIVMIWMLSAVLAVPEAigf 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  191 NVSPACYED------MGNNTANWRMLLRILPQ----SFGFIVPLLIMLFCYGF-----------TLRTLFKAHMGQKHRA 249
Cdd:cd15128 145 DMVRFNYKGvtlrtcLLRPETSFMKFYIDVKDwwlfGFYFCLPLVCTAIFYTLmtcemlrkrngMLRIALNEHLKQRREV 224
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504683  250 MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIdRALDATEI-LGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15128 225 AKTVFCLVVIFALCWLPLHLSRILKLTVYDQNDPNRCELLSFL-LVLDYFGInLATLNSCINPIALYFVSRKFKN 298
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
53-324 6.39e-09

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 56.41  E-value: 6.39e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPI--WAASKVNGWIFGTFLCKVVSLLKEVNF 130
Cdd:cd16002   5 VAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVinFTYAIHNEWYYGLEYCKFHNFFPIAAV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLsIWGLSLLLALPVLLFRRTvYSSNVSPACYEDMGNNTAN-WRM 209
Cdd:cd16002  85 FASIYSMTAIALDRYMAIIHPLQPRLSATATKVVICV-IWVLAFLLAFPQGYYSDT-EEMPGRVVCYVEWPEHEERkYET 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  210 LLRILPQSFGFIVPLLIMLFCYGFTLRTL------------FKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLadtlm 277
Cdd:cd16002 163 VYHVCVTVLIYFLPLLVIGCAYTVVGITLwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFL----- 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 4504683  278 rTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd16002 238 -LQYFHPELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRVG 283
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
52-322 6.88e-09

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 56.24  E-value: 6.88e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAAS----KVNGWIFGTFLCKVVSLLKE 127
Cdd:cd14995   4 TFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIesllGPDSWIYGYAGCLLITYLQY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVH---ATRTLTQKRylVKFICLSIWGLSLllalpvllfrrtVYSS------NVSPACYE 198
Cdd:cd14995  84 LGINASSLSITAFTIERYIAICHpmkAQFICTVSR--AKKIICFVWIFTS------------LYCSpwlfllDLSIKHYG 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  199 DMGNNTANWRM----LLRILPQSFG--FIVPLLIMLFCYGFTLRTLFKAhmgqKHRAMRVIFAVVLIFLLCWLPYNLVLL 272
Cdd:cd14995 150 DDIVVRCGYKVsrhyYLPIYLADFVlfYVIPLLLAIVLYGLIGRILFSS----RKQVTKMLAVVVVLFALLWMPYRTLVV 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 4504683  273 ADTLMRTQVIQetcerrnhiDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd14995 226 YNSFASPPYLD---------LWFLLFCRTCIYLNSAINPILYNLMSQKFR 266
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
50-322 6.99e-09

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 56.12  E-value: 6.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKE 127
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVaLLVMPLAIIYELSGyWPFGEILCDVWISFDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIvhaTRTL------TQKRYLVKFIC------------LSIWGLSlllalpvllfrrtvys 189
Cdd:cd15329  82 LLCTASILNLCAISVDRYLVI---TRPLtyavkrTPKRMALMIAIvwllsalisippLFGWKNK---------------- 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  190 SNVSPAC--YEDMGnntanwrmlLRILPQSFGFIVPLLIMLFCYGftlrTLFKAHMGQKhRAMRVIFAVVLIFLLCWLPY 267
Cdd:cd15329 143 VNDPGVCqvSQDFG---------YQIYATFGAFYIPLIVMLVLYY----KIYRAAKSER-KAIKTLGIIMGAFTLCWLPF 208
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4504683  268 NLVlladTLMRTQVIQETCerrNHIDRALDATEI-LGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15329 209 FIL----ALLRPFLKPIKC---SCIPLWLSRLFLwLGYANSFLNPIIYAKFNREFR 257
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
60-322 8.70e-09

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 55.90  E-value: 8.70e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   60 LLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLkevNFYSG---I 134
Cdd:cd15073  12 IISTISNGIVLVTFVKFRELRTPTNALIINLAVTdLGVSIIGYPFSAASDLhGSWKFGYAGCQWYAFL---NIFFGmasI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  135 LLLACISVDRYLAIVHAT--RTLTQKRYLVKFICLSIWGLSLLLALPVLLFRrtvYSSNVSPA-CyedmgnnTANWR--- 208
Cdd:cd15073  89 GLLTVVAVDRYLTICRPDlgRKMTTNTYTVMILLAWTNAFFWAAMPLVGWAS---YALDPTGAtC-------TINWRknd 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  209 -------MLLRILpqsfGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRV-----------IFAVVLIFLLCWLPYNLV 270
Cdd:cd15073 159 ssfvsytMSVIVV----NFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIdwtdqndvtkmSVIMIVMFLVAWSPYSIV 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 4504683  271 LLADTLMRTQVIQETCerrnHIDRALDATEilgilHSCLNPLIYAFIGQKFR 322
Cdd:cd15073 235 CLWASFGEPKKIPPWM----AIIPPLFAKS-----STFYNPCIYVIANKKFR 277
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
117-316 1.17e-08

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 55.60  E-value: 1.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  117 FLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWgLSLLLALPVLLFRRTVYSSNVSPAC 196
Cdd:cd15385  71 FLCRIVKHLQVLGMFASTYMLVMMTADRYIAICHPLKTLQQPTKRSYLMIGSAW-ALSFILSTPQYFIFSLSEIENGSGV 149
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  197 YEDMGNNTANWRMLLRILPQSFG-FIVPLLIMLFCYGFTLRTLFKAHMGQ----------------------------KH 247
Cdd:cd15385 150 YDCWANFIVPWGIKAYITWITISiFVVPVIILLTCYGFICYNIWRNIKCKtrrglsdnalknillavcvssvktisraKI 229
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504683  248 RAMRVIFAVVLIFLLCWLPYNlvlladTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAF 316
Cdd:cd15385 230 RTVKMTFVIVLAYIVCWAPFF------TIQMWSVWDQNFPWDESENTAVTITALLASLNSCCNPWIYMF 292
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
50-322 1.32e-08

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 55.43  E-value: 1.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWA-ASKVNG-WIFGTFLCKV-VSLlk 126
Cdd:cd15065   1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAvVNDLLGyWLFGETFCNIwISF-- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSG-ILLLACISVDRYLAI---VHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTV--------YSSNVSP 194
Cdd:cd15065  79 DVMCSTAsILNLCAISLDRYIHIkkpLKYERWMTTRRALVVIASVWILSALISFLPIHLGWHRLSqdeikglnHASNPKP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  195 ACYEDMGNNTAnwrmllrILPQSFGFIVPLLIMLFCY-------------------------GFTLRTLFKAHMGQK--- 246
Cdd:cd15065 159 SCALDLNPTYA-------VVSSLISFYIPCLVMLLIYsrlylyarkhvvniksqklpsesgsKFQVPSLSSKHNNQGvsd 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  247 HRAMRVIFAVVLIFLLCWLPYNLVlladtlmrtqviqetcerrnHIDRALDATEI----------LGILHSCLNPLIYAF 316
Cdd:cd15065 232 HKAAVTLGIIMGVFLICWLPFFII--------------------NIIAAFCKTCIppkcfkiltwLGYFNSCLNPIIYSI 291

                ....*.
gi 4504683  317 IGQKFR 322
Cdd:cd15065 292 FNSEFR 297
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
51-322 1.77e-08

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 54.92  E-value: 1.77e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEV 128
Cdd:cd15327   3 VGVFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIAdLLLSTTVLPFSATLEVLGfWAFGRVFCDIWAAVDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATR--TLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGnntan 206
Cdd:cd15327  83 CCTASILSLCVISVDRYVGVKHSLKypTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPPPPDESICSITEEPG----- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 wrmlLRILPQSFGFIVPLLIMLFCYGFTLRTLFKahMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMrtqviqetc 286
Cdd:cd15327 158 ----YALFSSLFSFYLPLMVILVMYFRVYVVALK--FSREKKAAKTLAIVVGVFILCWFPFFFVLPLGSFF--------- 222
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4504683  287 ERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15327 223 PALKPSEMVFKVIFWLGYFNSCVNPIIYPCSSKEFK 258
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
51-324 1.94e-08

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 54.83  E-value: 1.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEV 128
Cdd:cd15399   3 LILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVAdLMVNTLCLPFTLVYTLLDeWKFGAVLCHLVPYAQAL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSiWGLSLLLALPVLLFRRTVYSSNVS----PACYEDMGNNT 204
Cdd:cd15399  83 AVHVSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLT-WAASALLASPLAIFREYSVIEISPdfkiQACSEKWPNGT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILPQSFGFIVPLLIMLFCYgFTLRTLFKAHMG----------QKHRAMRVIFAVVLIFLLCWLPYNLVLLAD 274
Cdd:cd15399 162 LNDGTIYSVSMLLIQYVLPLAIISYAY-IRIWTKLKNHVSpgggndhyhqRRRKTTKMLVCVVVVFAVSWLPFHAFQLAS 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 4504683  275 TlmrtqvIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd15399 241 D------IDSKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTA 284
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
51-322 2.05e-08

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 54.49  E-value: 2.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEV 128
Cdd:cd15324   3 IVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASAdILVATLVIPFSLANEVMGyWYFGSTWCAFYLALDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATR-TLTQKRYLVKFICLSIWglsllLALPVLLFRRTVYSSNVSPACYEdmgnNTANW 207
Cdd:cd15324  83 FCTSSIVHLCAISLDRYWSVTKAVSyNLKRTPKRIKRMIAVVW-----VISAVISFPPLLMTKHDEWECLL----NDETW 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILpqsFGFIVPLLIMLFCYGFTLRTlfkAHMGQKhRAMRVIFAVVLIFLLCWLPYNLvlladtlmrTQVIQETCE 287
Cdd:cd15324 154 YILSSCT---VSFFAPGLIMILVYCKIYRV---AKMREK-RFTFVLAVVMGVFVLCWFPFFF---------TYSLHAVCR 217
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4504683  288 RRNHIDRAL-DATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15324 218 KRCGIPDALfNLFFWIGYCNSSVNPIIYTIFNRDFR 253
7tmA_ACKR1_DARC cd15010
Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G ...
256-326 2.08e-08

Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G protein-coupled receptors; Atypical chemokine receptor 1 (ACKR1), also known as DARC (Duffy antigen receptor for chemokines) or Fy glycoprotein (GpFy), was originally identified on erythrocytes. ACKR1 is also ubiquitously expressed by endothelial cells of venules and is highly promiscuous among all chemokine receptor. It binds many proinflammatory chemokines from both the CC and CXC subfamilies, including CCL2, CCL5, CCL7, CCL11, CXCL1, CXCL2, CXCL3, and CXCL5. Erythrocyte ACKR1 is thought to act as a chemokine sink, limiting the levels of circulating chemokines, thereby controlling leukocyte activation. ACKR1-deficient erythrocytes are shown to confer resistance to the malarial parasite, Plasmodium vivax. On the other hand, ACKR1-expressing endothelial cells can internalize chemokines. ACKR1-internalized chemokines can be moved intact across the endothelium and promotes neutrophil transmigration. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 410631  Cd Length: 257  Bit Score: 54.41  E-value: 2.08e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504683  256 VVLIFLLCWLPYNLVLLADTLMRTQVIQ-ETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLL 326
Cdd:cd15010 186 VLWLWFIFWWPYGVVLGLDFLVRSKLLLlSTCGAQEALDYMLGLSEALGILHCVATPLLLALVCHQATHTSP 257
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
57-329 2.45e-08

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 54.57  E-value: 2.45e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   57 LVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVNFYSGI 134
Cdd:cd15307   9 VLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITdLMVAVLVMPLGILTLVKGhFPLSSEHCLTWICLDVLFCTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  135 LLLACISVDRYLAIVHAT---RTLTQKRYLVKFI---CLSIwglsLLLALPVLLFRRTVYSSNVSPACYEDMGnntanwr 208
Cdd:cd15307  89 MHLCTISVDRYLSLRYPMrfgRNKTRRRVTLKIVfvwLLSI----AMSLPLSLMYSKDHASVLVNGTCQIPDP------- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  209 mLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAH------MGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTlmrtqVI 282
Cdd:cd15307 158 -VYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRsrhgriIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPT-----VC 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 4504683  283 QETCERRNHidRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKIL 329
Cdd:cd15307 232 AECEERISH--WVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVL 276
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
56-314 2.58e-08

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 54.53  E-value: 2.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   56 ALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVNFYSG 133
Cdd:cd15959   8 SLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMgLLVVPPGATILLTGhWPLGTTVCELWTSVDVLCVTAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  134 ILLLACISVDRYLAIVHATR--TLTQKRYLVKFICLsIWGLSLLLALPVLLFRRTVYSSNV-SPACYEDMGNNTANWRML 210
Cdd:cd15959  88 IETLCAIAVDRYLAITNPLRyeALVTKRRARTAVCL-VWAISAAISFLPIMNQWWRDGADEeAQRCYDNPRCCDFVTNMP 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  211 LRILPQSFGFIVPLLIMLFCYG--FTLRT----LFKAHMG--------------------------QKHRAMRVIFAVVL 258
Cdd:cd15959 167 YAIVSSTVSFYVPLLVMIFVYVrvFVVATrqvrLIRKDKVrfppeesppaesrpacgrrpsrllaiKEHKALKTLGIIMG 246
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4504683  259 IFLLCWLPYNLVLLADTLMRTQViqetcerrnhIDRALDATEILGILHSCLNPLIY 314
Cdd:cd15959 247 TFTLCWLPFFVANIIKVFCRSLV----------PDPAFLFLNWLGYANSAFNPIIY 292
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
51-322 2.90e-08

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 54.15  E-value: 2.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVflLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT-LP-IWAASKVNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15401   5 GVLIFTIV--VDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYpYPlILLAIFHNGWTLGNIHCQISGFLMGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATR--TLTQKRYLVKFICLSiWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTAN 206
Cdd:cd15401  83 SVIGSVFNITAIAINRYCYICHSLRydKLYNMKKTCCYVCLT-WVLTLAAIVPNFFVGSLQYDPRIYSCTFAQTVSSSYT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 wrmllrILPQSFGFIVPLLIMLFCY----------GFTLRTLFKAHMGQKH-RAMRVIFAVVLIFLLCWLPYNLVLLADT 275
Cdd:cd15401 162 ------ITVVVVHFIVPLSIVTFCYlriwvlviqvKHRVRQDSKQKLKANDiRNFLTMFVVFVLFAVCWGPLNFIGLAVA 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4504683  276 LMRTQViqetcerRNHIDRALDATE-ILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15401 236 INPLKV-------APKIPEWLFVLSyFMAYFNSCLNAVIYGVLNQNFR 276
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
50-322 3.71e-08

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 53.82  E-value: 3.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAAS-KVNG--WIFGTFLCKVVSLLK 126
Cdd:cd15310   2 YYALSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYlEVTGgvWNFSRICCDVFVTLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIV----HATRTLTQKRYLVKFICLSIWglslllalpvllfrrtVYSSNVSpaCYEDMGN 202
Cdd:cd15310  82 VMMCTASILNLCAISIDRYTAVVmpvhYQHGTGQSSCRRVSLMITAVW----------------VLAFAVS--CPLLFGF 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  203 NTANWRMLLRILPQSF-------GFIVPLLIMLFCYGFTLRTLFKahmgqKHRAMRVIFAVVLIFLLCWLPYNLvlladt 275
Cdd:cd15310 144 NTTGDPTVCSISNPDFviyssvvSFYLPFGVTLLVYVRIYVVLLR-----EKKATQMLAIVLGAFIVCWLPFFL------ 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4504683  276 lmrTQVIQETCeRRNHIDRAL-DATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15310 213 ---THILNTHC-QACHVPPELySATTWLGYVNSALNPVIYTTFNIEFR 256
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
50-325 4.36e-08

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 53.50  E-value: 4.36e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKE 127
Cdd:cd15059   2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVgLLIMPFSLVNELMGyWYFGSVWCEIWLALDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATR-TLTQKRYLVKFICLSIWGLSLLLAL-PVLLFRRTVYSSNVSPACyedmGNNTA 205
Cdd:cd15059  82 LFCTASIVNLCAISLDRYWSVTQAVEyNLKRTPRRAKAMIAAVWIISAVISLpPLFGWKDEQPWHGAEPQC----ELSDD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRIlpqSFGFIVPLLIMLFCYGftlrTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQET 285
Cdd:cd15059 158 PGYVLFSS---IGSFYIPLLIMIIVYA----RIYRAAKRKERRFTLVLGVVMGAFVLCWLPFFFTYPLVVVCKTCGVPEL 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4504683  286 cerrnhidrALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15059 231 ---------LFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
51-325 6.06e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 53.45  E-value: 6.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRS----------VTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFlck 120
Cdd:cd14972   1 VLVVAIVLGVFIVVENSLVLAAIIKNRRLHKpmyilianlaAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSL--- 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  121 VVSLLKEVNFysgilLLAcISVDRYLAIVHA---TRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPacy 197
Cdd:cd14972  78 VLSLLASAYS-----LLA-IAVDRYISIVHGltyVNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVLCDQESCSP--- 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  198 edmgnntanwrmLLRILPQSFG------FIVPLLIMLFCYgftLRTLFKAHM--------------GQKHRAMRVIFAVV 257
Cdd:cd14972 149 ------------LGPGLPKSYLvlilvfFFIALVIIVFLY---VRIFWCLWRhanaiaarqeaavpAQPSTSRKLAKTVV 213
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504683  258 LI---FLLCWLPYNLVLLADTLMRTQVIqetcerrnhIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14972 214 IVlgvFLVCWLPLLILLVLDVLCPSVCD---------IQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
54-322 6.39e-08

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 53.42  E-value: 6.39e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASK--VNGWIFGTFLCKVVSLLKEVNFY 131
Cdd:cd15125   6 LYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRyfYEEWMFGTVGCKLIPVIQLTSVG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  132 SGILLLACISVDRYLAIVHATRTLTQKRYLVKFI-CLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRML 210
Cdd:cd15125  86 VSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLkAIAIWVVSVLLAVPEAVFSEVAHIMPDDNTTFTACIPYPQTDEMH 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  211 LRI---LPQSFGFIVPLLIMLFCYGFTLRTLFK-AH-------------MGQKHRAMRVIFAVVLIFLLCWLPyNLVLLa 273
Cdd:cd15125 166 PKIhsvLIFLVYFLIPLAIISIYYYHIAKTLIKsAHnipgeysehskrqMETRKRLAKIVLVFVGLFAFCWFP-NHVLY- 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4504683  274 dtLMRTQVIQETCERRNHIDRALDAtEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15125 244 --MYRSFNYNEIDSSLGHMIVTLVA-RVLSFCNSCVNPFALYLLSESFR 289
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
50-322 9.87e-08

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 52.86  E-value: 9.87e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVflLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT-LP-IWAASKVNGWIFGTFLCKVVSLLKE 127
Cdd:cd15209   4 ACVLIVTIV--VDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYpYPlILHAIFHNGWTLGQLHCQASGFIMG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATR--TLTQKRYLVKFICLsIWglSLLLALPVLLFRrtVYSSNVSPACYEDMGNNTA 205
Cdd:cd15209  82 LSVIGSIFNITAIAINRYCYICHSLQydRLYSLRNTCCYLCL-TW--LLTVLAVLPNFF--IGSLQYDPRIYSCTFAQTV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILpqSFGFIVPLLIMLFCY----GFTLRTLFKAHMGQKH-------RAMRVIFAVVLIFLLCWLPYNLVLLAd 274
Cdd:cd15209 157 STVYTITVV--VIHFLLPLLIVSFCYlriwVLVLQVRQRVKPDQRPklkpadvRNFLTMFVVFVLFAVCWAPLNFIGLA- 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4504683  275 tlmrtqVIQETCERRNHIDRALDATE-ILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15209 234 ------VAINPKEMAPKIPEWLFVASyFMAYFNSCLNAIIYGLLNQNFR 276
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
54-323 1.14e-07

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 52.49  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVNFY 131
Cdd:cd15056   6 FLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVAdLLVAVLVMPFGAIELVNNrWIYGETFCLVRTSLDVLLTT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  132 SGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGN-------NT 204
Cdd:cd15056  86 ASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFISFLPIMQGWNHIGIEDLIAFNCASGStscvfmvNK 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 AnwrmlLRILPQSFGFIVPLLIMLFCY----------GFTLRTLFKA-------HMGQKHR------AMRVIFAVVLIFL 261
Cdd:cd15056 166 P-----FAIICSTVAFYIPALLMVLAYyriyvaareqAHQIRSLQRAgssnheaDQHRNSRmrtetkAAKTLGIIMGCFC 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504683  262 LCWLPYNLVLLADTLMRTQViqetcerrnhIDRALDATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15056 241 VCWAPFFVTNIVDPFIGYRV----------PYLLWTAFLWLGYINSGLNPFLYAFFNKSFRR 292
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
53-325 1.61e-07

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 52.11  E-value: 1.61e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAA--SKVNGWIFGTFLCKVVS----LLK 126
Cdd:cd14996   5 IIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAyfLKGFYWKYQSTQCRIANffgtLVI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIV-HATRTLTQKRY----------------LVKFICLSIWGLSLLLALPVLlfrrTVYS 189
Cdd:cd14996  85 HVSMCVSILILSWIAISRYATLMkHDSATQKQSCYekifyghflkrfrqpkFARYLCIYIWGVVLCIIIPVV----VYYS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  190 SNVSPA-----CYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFT--LRTLFK-AHMGQKH----RAMRVIFAVV 257
Cdd:cd14996 161 VREADEdgeslCYNRQVELGAKGSQIAGLIATTFFFLFFLVVLLSYYSFVnhLRRIQKnTCISEKDliyrSVKRNILIIQ 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504683  258 LIFLLCWLPYNLVLLADTLMRTqviQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14996 241 ALLVVCFLPYHIFKPVFYVLHQ---REDCQQLNYLIETKNILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
51-322 1.99e-07

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 51.72  E-value: 1.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWifGTFLCKVVSLLKE-VN 129
Cdd:cd15163   3 LMVINTLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIVMYYSAG--NCLTCSFVHIFSYfVN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVH--ATRTLTQKRYlVKFICLSIWglsllLALPVLLFRRTVYSSNVSPACyedmgnntanw 207
Cdd:cd15163  81 MYCSILFLTCICVDRYLAIVQveASRRWRNPNY-AKGICVFIW-----LFAIVVTFSILTTAIKFASCC----------- 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 rmLLRILPQS-FGFIVPLLIMLFcygFTLR--------TLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLAdTLMR 278
Cdd:cd15163 144 --LSKLFALTvFEFFLPLLIITF---FTIRimcalsrpGLMHQSRERRMRAVQLLITVLIIFMICFTPFHVRQVA-VAFN 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4504683  279 TQVIQETCERRNHIdraldaTEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15163 218 PDIPHHTSLIVYHV------TVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
51-322 2.39e-07

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 51.46  E-value: 2.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASK--VNGWIFGTFLCKVVSLLKEV 128
Cdd:cd15123   3 IYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRyiADTWLFGRIGCKLLSFIQLT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYL---VKFIClsIWGLSLLLALPVLLFrRTVYSsnvspacYEDMGNNT- 204
Cdd:cd15123  83 SVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLktcCKAGC--VWIVSMLFAIPEAVF-SDLYS-------FRDPEKNTt 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ----ANWRMLLRILPQSFG-------FIVPLLIMLFCYGFTLRTLFKA--------------HMGQKHRAMRVIFAVVLI 259
Cdd:cd15123 153 feacAPYPVSEKILQEIHSllcflvfYIIPLSIISVYYFLIARTLYKStfnmpaeehsharkQIESRKRVAKTVLVLVAL 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504683  260 FLLCWLPYNLVLladtLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15123 233 FAFCWLPNHILY----LYRSFTYHTSVDSSAFHLIATIFSRVLAFSNSCVNPFALYWLSKSFR 291
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
52-322 3.30e-07

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 51.06  E-value: 3.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVflLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT-LPIWAASKV-NGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15402   6 ILIFTIV--VDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYpYPLVLTSIFhNGWNLGYLHCQISGFLMGLS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVHATRtlTQKRYLVK---FICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTAN 206
Cdd:cd15402  84 VIGSIFNITGIAINRYCYICHSLK--YDKLYSDKnslCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSCTFAQSVSSAYT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLrilpqsFGFIVPLLIMLFCY------GFTLRTLFKAHMGQK-----HRAMRVIFAVVLIFLLCWLPYNLVLLADT 275
Cdd:cd15402 162 IAVVF------FHFILPIIIVTFCYlriwilVIQVRRRVKPDNKPKlkphdFRNFVTMFVVFVLFAVCWAPLNFIGLAVA 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 4504683  276 LMRTQVIQETCErrnhidRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15402 236 VDPETIVPRIPE------WLFVASYYMAYFNSCLNAIIYGLLNQNFR 276
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
54-322 3.89e-07

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 50.97  E-value: 3.89e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   54 IYALVFLLSLLGNSLVMLVILYS---RVGRSVTDVYLLNLALADLLFALTLPIWAASKV-NG-WIFGTFLCKVVSLLKEV 128
Cdd:cd15338   6 VFGVICFLGIIGNSIVIYTIVKKskfRCQQTVPDIFIFNLSIVDLLFLLGMPFLIHQLLgNGvWHFGETMCTLITALDTN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRT--LTQKRYLVKFICLsIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTAN 206
Cdd:cd15338  86 SQITSTYILTVMTLDRYLATVHPIRStkIRTPRVAVAVICL-VWILSLLSITPVWMYAGLMPLPDGSVGCALLLPNPETD 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 --WRMLLRILpqsFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRV--------IFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd15338 165 tyWFTLYQFF---LAFALPLVVICVVYFKILQNMASTVAPLPQRSLRVrtkkvtrmAVAICLAFFICWAPFYILQLAHLS 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4504683  277 MRTQVIQetcerrnhIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15338 242 IDRPSLA--------FLYAYNVAISMGYANSCINPFLYIMLSETFK 279
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
110-322 5.22e-07

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 50.60  E-value: 5.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  110 NGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAI---VHATRTLTQKRYLVKFIClsIWGLSLLLALPvllfrrt 186
Cdd:cd15306  65 AMWPLPLVLCPIWLFLDVLFSTASIMHLCAISLDRYIAIkkpIQASQYNSRATAFIKITV--VWLISIGIAIP------- 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  187 vyssnVSPACYEDMGNNTANWRMLLRilPQSFG----------FIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAV 256
Cdd:cd15306 136 -----VPIKGIETDVDNPNNITCVLT--KERFGdfilfgslaaFFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIV 208
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504683  257 VLIFLLCWLPYNLVLLadtlmrTQVIQETCErRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15306 209 FFLFLLMWCPFFITNI------TSVLCDSCN-QTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFR 267
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
53-325 5.36e-07

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 50.41  E-value: 5.36e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKEVNF 130
Cdd:cd15083   5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMcILNCPLMVISSFSGrWIFGKTGCDMYGFSGGLFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIvhaTRTLTQKRYLVK----FICLSIWgLSLLLALPVLLFRRTVYS-SNVSPACYEDMGNNTA 205
Cdd:cd15083  85 IMSINTLAAIAVDRYLVI---TRPMKASVRISHrralIVIAVVW-LYSLLWVLPPLFGWSRYVlEGLLTSCSFDYLSRDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWR---MLLRIlpqsFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMR---------------------VIFAVVLIFL 261
Cdd:cd15083 161 ANRsyvICLLI----FGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKRfskselsspkarrqaevktakIALLLVLLFC 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504683  262 LCWLPYNLVLLADTLMRTQVIQETcerrnhidrALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15083 237 LAWTPYAVVALIGQFGYLEVLTPL---------ATAIPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
119-321 5.39e-07

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 50.97  E-value: 5.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   119 CKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTlTQKRYLVKFICLSI-WGLSLLLALPVLLFRRTVYSSNVSPA-- 195
Cdd:PHA03235 105 CKFASLLYYASCTVGFATVALIAADRYRVIHQRTRA-RSSAYRSTYKILGLtWFASLICSGPAPVYTTVVAHDDVDPEap 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   196 ----C-----YEDMGNNTANWRMLLRILpqsFGfIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLP 266
Cdd:PHA03235 184 gyetCviyfrADQVKTVLSTFKVLLTLV---WG-IAPVVMMTWFYTFFYRTLKRASYKKRSRTLTFVCILLLSFLCLQTP 259
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 4504683   267 YNLVLLADTLMrTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKF 321
Cdd:PHA03235 260 FVAIMIFDSYA-TLIWPSDCEHINLRDAVSTLSRLVPNLHCLLNPILYAFLGNDF 313
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
50-322 1.09e-06

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 49.58  E-value: 1.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKE 127
Cdd:cd17790   2 LIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIgAFSMNLYTTYILMGhWALGTVACDLWLALDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIvhaTRTLT--QKRY---------LVKFICLSIWGLSLLLALPVLLfRRTVYSSNvspaC 196
Cdd:cd17790  82 VASNASVMNLLIISFDRYFSI---TRPLTyrAKRTprraaimigLAWLISFVLWAPAILFWQYLVG-ERTVLAGQ----C 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  197 YedmgnntanwrmlLRILPQ---SFG-----FIVPLLIMLFCYGFTLRTLFKahmgqKHRAMRVIFAVVLIFLLCWLPYN 268
Cdd:cd17790 154 Y-------------IQFLSQpiiTFGtaiaaFYLPVTIMIILYWRIYRETIK-----EKKAARTLSAILLAFILTWTPYN 215
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4504683  269 LVLLADTLMRTQVIQETCErrnhidraldATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd17790 216 IMVLVSTFCKDCVPKTLWE----------LGYWLCYVNSTVNPMCYALCNKSFR 259
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
53-322 1.13e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 49.55  E-value: 1.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVN 129
Cdd:cd15304   5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLgFLVMPVSMLTILYGyrWPLPSKLCAVWIYLDVLF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAI---VHATRTLTQKRYLVKFIclSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTan 206
Cdd:cd15304  85 STASIMHLCAISLDRYIAIrnpIHHSRFNSRTKAFLKII--AVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENF-- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 wrmllrILPQSF-GFIVPLLIMLFCYGFTLRTLfKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLvlladTLMRTQVIQET 285
Cdd:cd15304 161 ------VLIGSFvAFFIPLTIMVITYFLTIKSL-QQSISNEQKASKVLGIVFFLFVVMWCPFFI-----TNVMAVICKES 228
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4504683  286 CErRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15304 229 CN-EVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYR 264
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
50-322 1.26e-06

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 49.35  E-value: 1.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAA-SKVNGWIFGTFLCKVVSLLKE 127
Cdd:cd15397   2 FLVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSdILVCLVCLPFTVVyTLMDYWIFGEVLCKMTPFIQC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHAT--RTLTQKRYLVkfiCLSIWGLSLLLALPVLLFR---RTVYSS-NVSPACYEDMG 201
Cdd:cd15397  82 MSVTVSILSLVLIALERHQLIINPTgwKPSVSQAYLA---VVVIWMLACFISLPFLAFHiltDEPYKNlSHFFAPLADKA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  202 NNTANW-----RMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK------------AHMGQKHRAMRVIFAVVLIFLLCW 264
Cdd:cd15397 159 VCTESWpsehhKLAYTTWLLLFQYCLPLLFILVCYLRIYLRLRRrkdmlerrgeynRRAGHSKRINVMLVSLVAAFALCW 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4504683  265 LPYNLVLLADTLMRTQVIQetcerrNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15397 239 LPLNVFNAIADWNHEAIPH------CQHNLIFSLCHLAAMASTCVNPIIYGFLNSNFK 290
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
51-325 1.27e-06

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 49.25  E-value: 1.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKV-VSLlkE 127
Cdd:cd15051   3 LGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLgLLVLPFSAIYELRGeWPLGPVFCNIyISL--D 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNF-YSGILLLACISVDRYLAIV----HATRTLTQKrylVKFICLSIWglslllalpvllfrrtVYSSNVS--PAcyeDM 200
Cdd:cd15051  81 VMLcTASILNLFAISLDRYLAITaplrYPSRVTPRR---VAIALAAIW----------------VVSLAVSflPI---HL 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  201 GNNTANWRM--------------LLRILPQSFG-FIVPLLIMLFCYGFTLRT-------LFKAHMGQK------------ 246
Cdd:cd15051 139 GWNTPDGRVqngdtpnqcrfelnPPYVLLVAIGtFYLPLLIMCGVYLRIFRIareqakrINALTPASTanssksaatare 218
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504683  247 HRAMRVIFAVVLIFLLCWLPYnLVLLADTLMRTQVIQETcerrnhidrALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15051 219 HKATVTLAAVLGAFIICWFPY-FTYFTYRGLCGDNINET---------ALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
117-316 1.64e-06

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 49.03  E-value: 1.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  117 FLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIW---GLSLLLALPVLLFRRTVYSSNVS 193
Cdd:cd15386  71 LLCRAVKYLQVLSMFASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAYLMIGATWllsCILSLPQVFIFSLREVDQGSGVL 150
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  194 PaCYEDMGnntANWRMLLRILPQSFG-FIVPLLIMLFCYGFTLRTLFKAHMGQ--------------------------- 245
Cdd:cd15386 151 D-CWADFG---FPWGAKAYITWTTLSiFVLPVAILIVCYSLICYEICKNLKGKtqtsrsegggwrtqgmpsrvssvrtis 226
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504683  246 --KHRAMRVIFAVVLIFLLCWLPYNLVLLadtlmrTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAF 316
Cdd:cd15386 227 raKIRTVKMTFVIVLAYIACWAPFFSVQM------WSVWDENAPDEDSSDFAFTITMLLASLSSCCNPWIYMF 293
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
51-322 2.09e-06

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 48.70  E-value: 2.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT---LPIWAASKVNGWIFGTFLCKVVSLLKE 127
Cdd:cd15357   3 MSLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFgmpLEVYEMWSNYPFLFGPVGCYFKTALFE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRT-LTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTA- 205
Cdd:cd15357  83 TVCFASILSVTTVSVERYVAILHPFRAkLNSTRERALKIIVVLWVLSVLFSIPNTSIHGIKLQYFPNGTLIPDSATCTVv 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 --NWRMLLRILPQSFGF-IVPLLIMLFCY---GFTLR---TLFKAHMG------QKHRAMRVIFAVVLIFLLCWLPYNLv 270
Cdd:cd15357 163 kpLWIYNLIIQITSLLFyVLPMGVISVLYylmGLKLRgdkSLEADEMNvniqrpSRKSVTKMLFVLVLVFAICWAPFHV- 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 4504683  271 llaDTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15357 242 ---DRLFFSFVVEWTEPLANVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFR 290
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
112-325 2.53e-06

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 48.39  E-value: 2.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  112 WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVH--ATRTLTQKRYLVKFICLSiWGlslllALPVLLFRRTVYS 189
Cdd:cd15314  66 WYFGDLFCKIHSSFDITLCTASILNLCFISIDRYYAVCQplLYRSKITVRVVLVMILIS-WS-----VSALVGFGIIFLE 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  190 SNVSPACYEDM---GNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTL-------RTLFKAHMGQKH-------RAMRV 252
Cdd:cd15314 140 LNIKGIYYNHVaceGGCLVFFSKVSSVVGSVFSFYIPAVIMLCIYLKIFlvaqrqaRSIQSARTKSGAssskmerKATKT 219
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504683  253 IFAVVLIFLLCWLPYNLVLLADTLMR----TQVIqetcerrnhidralDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15314 220 LAIVMGVFLLCWTPFFLCNIIDPFINysipPVLI--------------EVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
51-322 2.71e-06

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 48.02  E-value: 2.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEV 128
Cdd:cd15322   3 LIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASAdILVATLVIPFSLANEVMGyWYFGKVWCEIYLALDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATR-TLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACyedmGNNTANW 207
Cdd:cd15322  83 FCTSSIVHLCAISLDRYWSITQAIEyNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGPIC----KINDEKW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 rmllRILPQSFG-FIVPLLIMLFCYgftlRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETc 286
Cdd:cd15322 159 ----YIISSCIGsFFAPCLIMVLVY----IRIYQIAKNREKRFTFVLAVVIGVFVICWFPFFFTYTLTAVCDCSVPETL- 229
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4504683  287 errnhidraLDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15322 230 ---------FKFFFWFGYCNSSLNPVIYTIFNHDFR 256
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
51-322 4.26e-06

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 47.42  E-value: 4.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKEV 128
Cdd:cd15050   3 LGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVgAVVMPLNIVYLLESkWILGRPVCLFWLSMDYV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTL---TQKRYLVKFI---CLS------IWGlslllalpVLLFRRTVYSSNVSPAC 196
Cdd:cd15050  83 ASTASIFSLFILCIDRYRSVQQPLKYLkyrTKTRASLMISgawLLSflwvipILG--------WHHFARGGERVVLEDKC 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  197 YEDMGNNTanwrmLLRILPQSFGFIVPLLIMLFCYGftlrTLFKAhMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd15050 155 ETDFHDVT-----WFKVLTAILNFYIPSLLMLWFYA----KIFKA-VNRERKAAKQLGFIMAAFILCWIPYFILFMVIAF 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4504683  277 MRTqviqeTCERRNHIdraldATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15050 225 CKN-----CCNENLHM-----FTIWLGYINSTLNPFIYPLCNENFK 260
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
49-323 4.26e-06

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 47.93  E-value: 4.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLAL-ADLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLK 126
Cdd:cd15976   1 YINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALgDLLHIIIDIPINVYKLLaEDWPFGVEMCKLVPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATR--TLTQKRYLVKFICLsIW------------GLSLLLALPVLLFRRTVYSSNV 192
Cdd:cd15976  81 KASVGITVLSLCALSIDRYRAVASWSRikGIGVPKWTAVEIVL-IWvvsiilavpeaiGFDMITMDYKGELLRICLLHPI 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  193 SPACYEDMGNNTANWRMLlrilpqSFGFIVPLLIMLFCYGFTLRTLFKA----------HMGQKHRAMRVIFAVVLIFLL 262
Cdd:cd15976 160 QKTAFMQFYKTAKDWWLF------SFYFCLPLACTAVFYTLMTCEMLRKkngmqialndHLKQRREVAKTVFCLVLVFAL 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504683  263 CWLPYNLVLLADTLMRTQVIQETCERRNHIdRALDATEI-LGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15976 234 CWLPLHLSRILKLTIYDEKDPNRCELLSFF-LVLDYIGInMASLNSCINPIALYLVSKRFKN 294
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
51-322 4.41e-06

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 47.92  E-value: 4.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKEV 128
Cdd:cd15403   3 LAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSdIMLSLLCMPFTAVTIITVdWHFGAHFCRISAMLYWF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRylVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPAC---YEDMGNNTA 205
Cdd:cd15403  83 FVLEGVAILLIISVDRFLIIVQRQDKLNPHR--AKVMIAISWVLSFCISFPSVVGWTLVEVPARAPQCvlgYTESPADRV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILpqsfgFIVPLLIMLFCYGFTLRT---------------------------LFKAH-----MGQKHRAMRVI 253
Cdd:cd15403 161 YAVLLVVAV-----FFVPFSIMLYSYLCILNTvrrnavrihnhadslclsqvsklglmgLQRPHqmnvdMSFKTRAFTTI 235
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504683  254 FAVVLIFLLCWLPYNLVLLADTLmrtqviqetcERRNHIDRALDATEI----LGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15403 236 LILFVGFSLCWLPHTVFSLLSVF----------SRRFYYSSSFYPISTcvlwLSYLKSVFNPVIYCWRIKKFR 298
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
114-318 4.45e-06

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 47.63  E-value: 4.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  114 FGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIV-----HATRtltqKRYLVKFICLSIWGLSLLLALPVLLFRRTVY 188
Cdd:cd14973  66 PGFALCRLLATLMFFSYTVGLSLLAAISTERCLSVLfpiwyRCHR----PKHLSAVVCALLWALSLLLSVLESYFCGFLF 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  189 SSNVSPACYEDMgnntanwrmLLRILpqsfGFIVPLLIMLFCYGFTLRTLFKAHMGQK-HRAMRVIFAVVLIFLLCWLPY 267
Cdd:cd14973 142 WKFNESACRTFN---------FLSAL----LFLLLFLVMCVSSLTLLIRVQCSSQRRPpTRLYVVILLTVLVFLLCGLPL 208
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 4504683  268 NLVLLADTLMRTqviqetcerrNHIDRALDATEILGILHSCLNPLIYAFIG 318
Cdd:cd14973 209 GIYWFLLLWFSN----------YLFHTFHPISDLLSCVNSSANPIIYFFVG 249
7tmA_GPR146 cd14990
G protein-coupled receptor 146, member of the class A family of seven-transmembrane G ...
53-325 5.57e-06

G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR146 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. The endogenous ligand for GPR146 is not known. It has been suggested that GPR146 may be a part of the C-peptide signaling complex. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320121  Cd Length: 280  Bit Score: 47.47  E-value: 5.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALV-FLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPI---------WAASKVNGWIFGTFLC--K 120
Cdd:cd14990   4 LLYLIIcFPVGLCYNALLVLVNLYNKASMTMPDVYFVNMAIAGLVLNAVAPVqllgpdntrWPLWNSNNEVYITLLIlfN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  121 VVSLlkeVNFYSGILLlaciSVDRYLAIVhATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFrrtVYSSNVSPACYE-- 198
Cdd:cd14990  84 VSSL---VSMYSTTLL----SLDYYIERA-LPRTYMSSVYNTKHVCGFIWGGAVLTSFSSLLF---YICSHVSTKIIEcs 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  199 DMGNNTANWRMLLRIlpqsfGFIVPLLIMLFCYGFTLR-----TLFKAHMGQ-KHRAMRVIFAVVLIFLLCWLPYNLVLL 272
Cdd:cd14990 153 KMQNKEAADAIMVFI-----GYVVPALAVLYALVLILRirkeaTPLDQDSGRlDPSAHRLLLATVCTQFLLWTPYYMILL 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4504683  273 ADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd14990 228 VHTVQASRGKKVDAGYLRVFHFLKGLSKLLAFSSSFVVPLLYRYMNKNFSSKL 280
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
51-329 7.25e-06

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 47.16  E-value: 7.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLV-ILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGW-IFGTFLCKVVSLLKEV 128
Cdd:cd15084  13 VAVLMGMVVALASFVNGLVIVVsIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFfVFGKTMCEFEGFMVSL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPAC---YEDMGNNTA 205
Cdd:cd15084  93 TGIVGLWSLAILAFERYLVICKPMGDFRFQQRHAVSGCAFTWGWSLLWTSPPLFGWSSYVPEGLRTSCgpnWYTGGTNNN 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILpqsfGFIVPLLIMLFCYGFTLRTLFKAHMGQK-----HRA----MRVIFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd15084 173 SYILALFVT----CFALPLSTIIFSYSNLLLTLRAVAAQQKesettQRAekevTRMVIAMVMAFLICWLPYATFAMVVAT 248
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4504683  277 MRTQVIQETCErrnhidralDATEILGILHSCLNPLIYAFIGQKFRHGLLKIL 329
Cdd:cd15084 249 NKDVVIQPTLA---------SLPSYFSKTATVYNPIIYVFMNKQFRSCLLELL 292
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
52-322 9.00e-06

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 46.77  E-value: 9.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVflLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT-LP-IWAASKVNGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15400   6 VLIFTTV--VDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYpYPlVLVAIFHNGWALGEMHCKVSGFVMGLS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYLAIVH--ATRTLTQKRYLVKFICLsIWGLSLLLALPVLLfrrtVYSSNVSPACYEDMGNNTANW 207
Cdd:cd15400  84 VIGSIFNITGIAINRYCYICHsfAYDKLYSRWNTLLYVCL-IWALTVVAIVPNFF----VGSLEYDPRIYSCTFVQTASS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILpqSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKH-----------RAMRVIFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd15400 159 SYTIAVV--VIHFIVPITVVSFCYLRIWVLVIQVRRKVKSeskprlkpsdfRNFLTMFVVFVIFAICWAPLNLIGLAVAI 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4504683  277 MRTQVIQETCErrnhidRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15400 237 NPQEMAPKVPE------WLFVVSYFMAYFNSCLNAIIYGLLNQNFR 276
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
53-314 9.73e-06

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 46.78  E-value: 9.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV--NGWIFGTFLCKVVSLLKEVNF 130
Cdd:cd15957   5 IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHIllKTWTFGNFWCEFWTSIDVLCV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATR---TLTQKRYLVkfICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANW 207
Cdd:cd15957  85 TASIETLCVIAVDRYFAITSPFKyqsLLTKNKARV--IILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  208 RMLLRILPQSFGFIVPLLIMLFCYG-------------------FTLRTLFKAHMG-------------QKHRAMRVIFA 255
Cdd:cd15957 163 NQAYAIASSIVSFYVPLVIMVFVYSrvfqeakrqlqkidksegrFHNQNIDQNGSGggggnrrrskfclKEHKALKTLGI 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4504683  256 VVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIdraldateilGILHSCLNPLIY 314
Cdd:cd15957 243 IMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWI----------GYVNSGFNPLIY 291
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
218-321 1.01e-05

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 46.65  E-value: 1.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  218 FGFIVPLLIMLFCYG---FTLRTLFKAH-MGQKHRAMRVIFAV---VLIFLLCWLPYNLVLLADTLMRTQVIQETcerrn 290
Cdd:cd15086 171 FCLLLPFLVMVYCYGrllYAIKQVGKINkSTARKREQHVLLMVvtmVICYLLCWLPYGVMALLATFGKPGLVTPV----- 245
                        90       100       110
                ....*....|....*....|....*....|.
gi 4504683  291 hidrALDATEILGILHSCLNPLIYAFIGQKF 321
Cdd:cd15086 246 ----ASIVPSILAKSSTVVNPIIYVFMNKQF 272
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
52-316 1.66e-05

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 45.88  E-value: 1.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPI---WAASKVNGwIFGTFLCKVVSLLKEV 128
Cdd:cd14964   2 TIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVlffLLGLTEAS-SRPQALCYLIYLLWYG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRY-LVKFICLSIWG-----LSLLLALPVLLFRRTVYSSNVSPACyedmGN 202
Cdd:cd14964  81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPgKTRVIILGCWGvslllSIPPLVGKGAIPRYNTLTGSCYLIC----TT 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  203 NTANWRMLLrilpqsFGFIVPLLIMLFCYGFTLRTLFKA----------HMGQKHRAMRVIFAVVLIFLLCWLPYNLVLL 272
Cdd:cd14964 157 IYLTWGFLL------VSFLLPLVAFLVIFSRIVLRLRRRvrairsaaslNTDKNLKATKSLLILVITFLLCWLPFSIVFI 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4504683  273 ADTLMRTQVIqetcerrnhIDRALDATEILGILHSCLNPLIYAF 316
Cdd:cd14964 231 LHALVAAGQG---------LNLLSILANLLAVLASTLNPFIYCL 265
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
52-322 1.82e-05

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 46.01  E-value: 1.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDV----YLLNLALADLLFALTLPIWAASKV---NGWIFGTFLCKVVSL 124
Cdd:cd15356   4 TAVYALIWALGAAGNALTIHLVLKKRSLRGLQGTvhyhLVSLALSDLLILLISVPIELYNFVwfhYPWVFGDLVCRGYYF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  125 LKEVNFYSGILLLACISVDRYLAIVH---ATRTLTQKRylVKFICLSIWGLSLLLALPVLLFRRTVYsSNVSPACYEDMG 201
Cdd:cd15356  84 VRDICSYATVLNIASLSAERYLAICQplrAKRLLSKRR--TKWLLALIWASSLGFALPMAFIMGQKY-ELETADGEPEPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  202 NNTANW---RMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNlvllADTLMR 278
Cdd:cd15356 161 SRVCTVlvsRATLKVFIQVNAFVSFVLPLALIAFLNGVTVSHLRIQSLQHSVQVLRAIVIAYVICWLPYH----ARRLMF 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4504683  279 TQVIQE--TCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15356 237 CYVPDDawTDSLYNFYHYFYMLTNTLFYVSSAVNPLLYNVVSSSFR 282
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
53-267 2.37e-05

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 45.52  E-value: 2.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDV-YLLNLALADLLFALTLPIWAASKV-NGWIFGTFLCKVVSLLKEVNF 130
Cdd:cd15220   4 FCMVLLDLTALVGNTAVMVVIAKTPHLRKFAFVcHLCVVDLLAALLLMPLGILSSSPFfLGVVFGEAECRVYIFLSVCLV 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATR-TLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRM 209
Cdd:cd15220  84 SASILTISAISVERYYYIVHPMRyEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGGPAPIAARHCSLHWSHSGHRG 163
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4504683  210 LLRILPQSFGFIVPLLIMLFCYGftlrTLFKAHMGQKhrAMRVIFAVVLIFLLCWLPY 267
Cdd:cd15220 164 VFVVLFALVCFLLPLLLILVVYC----GVFKVFGGGK--AALTLAAIVGQFLCCWLPY 215
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
112-322 2.38e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 45.42  E-value: 2.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  112 WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAI---VHATRTLTQKRYLVkFICLSiWglslllaLPVLLFRRTVY 188
Cdd:cd15312  66 WYFGDLFCKIHSSLDMMLSTTSIFHLCFIAVDRYYAVcdpLHYRTKITTPVIKV-FLVIS-W-------SVPCLFAFGVV 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  189 SSNVSPACYEDMGNNTA-----------NWRMLLRILpqsfGFIVPLLIM--LFCYGFTL-----RTLFKAHMGQK---- 246
Cdd:cd15312 137 FSEVNLEGIEDYVALVSctgscvlifnkLWGVIASLI----AFFIPGTVMigIYIKIFFVarkhaKVINNRPSVTKgdsk 212
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  247 --------HRAMRVIFAVVLIFLLCWLPYNLVLLADTLM--RTQVIqetcerrnhidrALDATEILGILHSCLNPLIYAF 316
Cdd:cd15312 213 nklskkkeRKAAKTLSIVMGVFLLCWLPFFVATLIDPFLnfSTPVD------------LFDALVWLGYFNSTCNPLIYGF 280

                ....*.
gi 4504683  317 IGQKFR 322
Cdd:cd15312 281 FYPWFQ 286
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
51-322 2.43e-05

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 45.60  E-value: 2.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT---LPIWAASKVNGWIFGTFLCKVVSLLKE 127
Cdd:cd15133   3 VCLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLgmpLELYELWQNYPFLLGSGGCYFKTFLFE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQK-RYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNN-TA 205
Cdd:cd15133  83 TVCLASILNVTALSVERYIAVVHPLAARTCStRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSGVPASAQCTVRKpQA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 NWRMLLRILPQSFGFIVPLLIMLFCYGFTLR---------TLFKAHMGQK-HRAM----------RVIFAVVLIFLLCWL 265
Cdd:cd15133 163 IYNMIPQHTGHLFFVLPMAVISVLYLLMALRlarergldaTGAGSKIGTRtGQLLqhprtraqvtKMLFILVVVFAICWA 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504683  266 PYNlvllADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15133 243 PFH----IDRLMWSFISDWTDNLHEVFQYVHIISGVFFYLSSAVNPILYNLMSTRFR 295
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
49-322 2.47e-05

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 45.28  E-value: 2.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASK--VNGWIFGTFLCKVVSLLK 126
Cdd:cd15124   1 YAIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRylADEWLFGRVGCKLIPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIV--------HATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYE 198
Cdd:cd15124  81 LTSVGVSVFTLTALSADRYKAIVrpmdiqasNALMKICLKAALIWILSMLLAIPEAVFSDLHPFYDKSTNKTFVSCAPYP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  199 DMGNNTANWRMLLRILpqsFGFIVPLLIMLFCYGFTLRTLF--------------KAHMGQKHRAMRVIFAVVLIFLLCW 264
Cdd:cd15124 161 HSNELHPKIHSMASFL---IFYVIPLSIISVYYYFIAKNLIrsaynlpvegnvhvRRQIESRKRLAKTVLVFVGLFAFCW 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504683  265 LPYNLVLLADTLMRTQV-------IQETCERrnhidraldateILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15124 238 LPNHIIYLYRSYHYSEVdtsmlhfVSSICAR------------ILAFTNSCVNPFALYLLSKSFR 290
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
49-322 2.56e-05

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 45.48  E-value: 2.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT-LPIWAASKVN-GWIFGTFLCKVVSLLK 126
Cdd:cd15336   1 YTVGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTqSPIFFVNSLHkRWIFGEKGCELYAFCG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAI---VHATRTLTQKRylVKFICLSIWgLSLLLALPVLLFRRTVY-SSNVSPACYEDMGN 202
Cdd:cd15336  81 ALFGITSMITLLAISLDRYLVItkpLASIRWVSKKR--AMIIILLVW-LYSLAWSLPPLFGWSAYvPEGLLTSCTWDYMT 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  203 NTANWRMLLRILpQSFGFIVPLLIMLFCYGFTLRTLFKA--------------------HMGQKHRAMRVIFAVVLIFLL 262
Cdd:cd15336 158 FTPSVRAYTMLL-FCFVFFIPLGIIIYCYLFIFLAIRSTgrevqklgsqdrkekakqyqRMKNEWKMAKIAFVVILLFVL 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  263 CWLPYNLVLLADTLMRTQVIqetcerrNHIDRALDAteILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15336 237 SWSPYACVALIAWAGYAHLL-------TPYMKSVPA--VIAKASAIYNPIIYAITHPKYR 287
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
52-323 2.82e-05

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 45.32  E-value: 2.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLaladllfaltlpiwAASKVNGWIFGTFLCKVVSLLKEVNFY 131
Cdd:cd14968   4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSL--------------AVADILVGALAIPLAILISLGLPTNFH 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  132 --------------SGILLLACISVDRYLAIVHATR---TLTQKR------------YLVKFICLSIWGLSLLLALPVLL 182
Cdd:cd14968  70 gclfmaclvlvltqSSIFSLLAIAIDRYLAIKIPLRyksLVTGRRawgaiavcwvlsFLVGLTPMFGWNNGAPLESGCGE 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  183 FRRTVYSSNVSPACYedmgnntanwrMLLRILpqsFGFI-VPLLIMLFCYGFTLRTLFK---------------AHMGQK 246
Cdd:cd14968 150 GGIQCLFEEVIPMDY-----------MVYFNF---FACVlVPLLIMLVIYLRIFRVIRKqlrqiesllrsrrsrSTLQKE 215
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504683  247 HRAMRVIFAVVLIFLLCWLPYNLVlladtlmrtQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd14968 216 VKAAKSLAIILFLFALCWLPLHII---------NCITLFCPECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQ 283
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
50-324 2.94e-05

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 45.20  E-value: 2.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFAL--TLPIWAASKVNGWIFGTFLCKVVSLLKE 127
Cdd:cd15981   2 MFILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIfcMPTTLVDNLITGWPFDNAMCKMSGLVQG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATR-TLTQKRYLVKFIClsIW----------GLSLLLALPVLLFRRTVYsSNVSP-- 194
Cdd:cd15981  82 MSVSASVFTLVAIAVERFRCIVHPFRqKLTLRKAIVTIVI--IWvlaliimcpsAVTLTVTREEHHFMVDDY-NNSYPly 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  195 ACYEDMGNNtaNWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHM----------------GQKHRAMRVIFAVVL 258
Cdd:cd15981 159 SCWEAWPDT--EMRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSApirgsqgeeeegrrvsKRKIKVINMLIIVAL 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504683  259 IFLLCWLP-YNLVLLAD--TLMRTQVIQETCerrnhidRALDATEILGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd15981 237 FFTLSWLPlWTLMLLTDygHLSEDQLNLVTV-------YVFPFAHWLAFFNSSVNPIIYGYFNENFRRG 298
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
50-276 2.96e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 44.93  E-value: 2.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIyaLVFLLSLLGNsLVMLVILYSR---VGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLK 126
Cdd:cd15214   3 SIAII--IIAILICLGN-LVIVVTLYKKsylLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHAT---RTLTQKRYLVKFIclSIWGLSLLLALPVLLFRRTVYSSNVSPAC---YEDM 200
Cdd:cd15214  80 LLISSASMLTLGAIAIDRYYAVLYPMvypMKITGNRAVLALV--YIWLHSLIGCLPPLFGWSSLEFDRFKWMCvaaWHKE 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504683  201 GNNTANWrmllrilpQSFGFIVPLLIMLFCYGFtlrtLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd15214 158 AGYTAFW--------QVWCALLPFVVMLVCYGF----IFRVARANQCKAFITILVVLGAFVTTWGPYMVVISTEAL 221
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
105-322 3.22e-05

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 44.84  E-value: 3.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  105 AASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATR---TLTQKRYLVKFICLSI------------ 169
Cdd:cd15215  58 ATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSyptKMTPRRGYLLIYGTWIvsvlqstpplyg 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  170 WGLSLLLalpvllfRRTVYSSNVSPACYEdmgnntanwrmlLRILPQSFGFIVPLLIMLFCYGFtlrtLFKAHMGQKH-R 248
Cdd:cd15215 138 WGQAAFD-------ERNALCSVIWGSSYS------------YTILSVVSSFVLPVIIMLACYSM----VFRAARRCYHcK 194
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504683  249 AMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETcerrnhIDRALdateILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15215 195 AAKVIFIIIFSYVLSMGPYSFLSVLAVWVDTQVPQWV------ISIIL----WLFFLQCCIHPYIYGYMHKSIK 258
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
50-322 3.73e-05

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 44.62  E-value: 3.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKE 127
Cdd:cd15049   2 LICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIgLVSMNLYTVYLVMGyWPLGPLLCDLWLALDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIvhaTRTLT--QKRYLVKFICLSI--WGLSLLLALPVLLF------RRTVYSSnvspACY 197
Cdd:cd15049  82 VASNASVMNLLLISFDRYFSV---TRPLTyrAKRTPKRAILMIAlaWVISFVLWAPAILGwqyfvgERTVPDG----QCY 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  198 EDMGNNTAnwRMLLRILPqsfGFIVPLLIMLFCYGFTLRTLFKAhmgqkHRAMRVIFAVVLIFLLCWLPYNLVLLADTLM 277
Cdd:cd15049 155 IQFLDDPA--ITFGTAIA---AFYLPVLVMTILYWRIYRETARE-----RKAARTLSAILLAFIITWTPYNILVLVSTFC 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4504683  278 RTQViqetcerrnhIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15049 225 AKCI----------PDTLWSFGYWLCYINSTINPFCYALCNKTFR 259
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
49-322 3.90e-05

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 44.65  E-value: 3.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTD-VYLLNLALADLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLK 126
Cdd:cd15331   1 VLTSIILGLLILATIIGNVFVIAAILLERSLQGVSNyLILSLAVADLMVAVLVMPLSAVYEVSQhWFLGPEVCDMWISMD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHAT--RTLTQKRYLVKFIClsIWgLSLLLALPVLLFRRTVYSSNVSPacyEDMGNNT 204
Cdd:cd15331  81 VLCCTASILHLVAIALDRYWAVTNIDyiRRRTAKRILIMIAV--VW-FVSLIISIAPLFGWKDEDDLDRV---LKTGVCL 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ANWRMLLRILPQSFGFIVPLLIMLFCYgftlrtlFKAHMGQKHR--AMRVIFAVVLIFLLCWLPYNLVLLadtlmrtqvI 282
Cdd:cd15331 155 ISQDYGYTIFSTVGAFYVPLLLMIIIY-------WKIYQAAKRErkAARTLAIITGAFVVCWLPFFLVAL---------V 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4504683  283 QETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15331 219 MPFCGAWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFR 258
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
52-271 3.91e-05

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 44.81  E-value: 3.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLkeVNF 130
Cdd:cd15166   4 LVFYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDeWPFGDYFCRILGAL--TVF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGIL--LLACISVDRYLAIVHA--TRTLTQKRYLVkFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDM------ 200
Cdd:cd15166  82 YPSIAlwLLAFISADRYMAIVQPkhAKELKNTPKAV-LACVGVWIMTLASTFPLLFLYEDPDKASNFTTCLKMLdiihlk 160
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504683  201 GNNTANWRMLLrilpqsFGFIVPLLIMLFCYGFTLRTLFKAHMGQ-----KHRAMRVIFAVVLIFLLCWLPYNLVL 271
Cdd:cd15166 161 EVNVLNFTRLI------FFFLIPLFIMIGCYLVIIHNLVHGRTSKlkpkvKEKSIRIIITLIVQVLVCFVPFHICF 230
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
112-325 5.00e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 44.47  E-value: 5.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  112 WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSI-WGLSLLLALPVllfrrtVYSS 190
Cdd:cd15318  66 WYFGDSFCRLHTCLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAgWLVPTVYTSVF------LYTK 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  191 NVSPACYEDMGNN--TANWRMLLRILPQSFG---FIVPLLIMLFCYG--FT--------LRTLFKAHMG---QKHRAMRV 252
Cdd:cd15318 140 AVEEGLAELLTSVpcVGSCQLLYNKLWGWLNfpvFFIPCLIMIGLYVkiFIvakrqaraIASLLSDTNGaskRERKAAKT 219
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504683  253 IFAVVLIFLLCWLPYNLVLLADTLMrtqviqetcerrNHIDRAL--DATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15318 220 LGIAVGVYLLCWLPFTIDTMVDSLL------------NFITPPLlfDIIIWFAYFNSACNPLIYVFSYPWFRKAL 282
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
112-322 6.30e-05

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 44.17  E-value: 6.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  112 WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHA---TRTLTQKRylVKFICLSIWGLSLLLALPVLLFRRTVY 188
Cdd:cd15334  66 WIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAveyARKRTPKH--AGIMIAVVWIISIFISMPPLFWRHQTT 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  189 SSNVSPACYEDMgnntanwrmLLRILPQSFG-FIVPLLIMLFCYgftlRTLFKAhMGQKHRAMRVIFAVVLIFLLCWLPY 267
Cdd:cd15334 144 SREDECIIKHDH---------IVFTIYSTFGaFYIPLALILILY----YKIYRA-ATRERKAATTLGLILGAFVICWLPF 209
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4504683  268 NLvlladtlmrTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15334 210 FV---------KEVIVNTCDSCYISEEMSNFLTWLGYINSLINPLIYTIFNEDFK 255
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
220-272 6.84e-05

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 44.07  E-value: 6.84e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504683  220 FIVPLLIMLFCYGFTLRTLF-----------KAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLL 272
Cdd:cd15085 173 FVIPVAIIGFSYGNVLRSLHklnkkieqqggKNCPEEEERAVIMVLAMVIAFLICWLPYTVFAL 236
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
213-322 7.00e-05

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 44.13  E-value: 7.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  213 ILPQSF-GFIVPLLIMLFCYGFTLRTLFKAH-MGQKHRAMRVIFAVVLIFLLCWLPYNLvlladTLMRTQVIQETCErRN 290
Cdd:cd15305 161 VLIGSFvAFFIPLIIMVITYCLTIQVLQRQQaINNERRASKVLGIVFFLFLIMWCPFFI-----TNILSVLCKEACD-QK 234
                        90       100       110
                ....*....|....*....|....*....|..
gi 4504683  291 HIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15305 235 LMEELLNVFVWVGYVSSGINPLVYTLFNKTYR 266
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
51-323 8.01e-05

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 43.66  E-value: 8.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKEV 128
Cdd:cd15301   3 IVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIgVISMPLFTVYTALGyWPLGYEVCDTWLAIDYL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIvhaTRTLT--QKRYLVKFICL--SIWGLSLL------LALPVLLFRRTV-----YSSNVS 193
Cdd:cd15301  83 ASNASVLNLLIISFDRYFSV---TRPLTyrARRTTKKAAVMiaSAWIISLLlwppwiYSWPYIEGKRTVpagtcYIQFLE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  194 PACYEDMGNNTAnwrmllrilpqsfGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLA 273
Cdd:cd15301 160 TNPYVTFGTALA-------------AFYVPVTIMCILYWRIWRETKKRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLI 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 4504683  274 DTLMrtqviqeTCErrNHIDRAL-DATEILGILHSCLNPLIYAFIGQKFRH 323
Cdd:cd15301 227 KAFF-------PCS--DTIPTELwDFSYYLCYINSTINPLCYALCNAAFRR 268
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
117-325 8.04e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 44.04  E-value: 8.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  117 FLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVkFICLSIWGLSLLLALPVLLFRRTvyssNVSPAC 196
Cdd:cd15387  71 FLCRLVKYLQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRV-YVLFSWLLSLVFSIPQVHIFSLR----EVGNGV 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  197 YEDMGNNTANWRMLLRILPQSFG-FIVPLLIMLFCYG---------FTLRTLFKAHMGQ--------------------- 245
Cdd:cd15387 146 YDCWADFIQPWGPKAYITWITLSvYIIPVLILSVCYGlisfkiwqnVKLKTRRETKTPLssaasggaalarvssvklisk 225
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  246 -KHRAMRVIFAVVLIFLLCWLPYNLVLLAdTLMRTQVIQEtcerrnhiDRALDATEILGILHSCLNPLIYAFIGQKFRHG 324
Cdd:cd15387 226 aKIRTVKMTFVIVLAYIVCWTPFFFVQMW-SVWDPNAPKE--------ASPFIIAMLLASLNSCCNPWIYMFFTGHLFHD 296

                .
gi 4504683  325 L 325
Cdd:cd15387 297 L 297
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
52-268 8.09e-05

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 43.84  E-value: 8.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGnslVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV--NGWIFGTFLCKVVSLLKEVN 129
Cdd:cd15169   8 VAAFALGFPLNVLA---IRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALasGAWPLPASLCPVFAVAHFAP 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  130 FYSGILLLACISVDRYL--AIVHATRTLTQKRYLVKfICLSIWGLSLLLALPVLLFR------RTVYSS-------NVSP 194
Cdd:cd15169  85 LYAGGGFLAALSAGRYLgaAFPLGYQAFRRPCYSWG-VCAAIWALVLCHLGLVFGLEapggwlDHSNTSlgintpvNGSP 163
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504683  195 ACYEDMGNNTAN-WRMLLRILPqsfgFIVPLLIMLFCYGFTLRTLfkAHMGQKH----RAMRVIFAVVLIFLLCWLPYN 268
Cdd:cd15169 164 VCLEAWDPASAGpARFSLSLLL----FFLPLAITAFCYVGCLRAL--ARSGLTHrrklRAAWVAGGALLTLLLCVGPYN 236
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
112-322 8.37e-05

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 43.76  E-value: 8.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  112 WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHA---TRTLTQKRylVKFICLSIWgLSLLLALPVLLFRRTVY 188
Cdd:cd15335  66 WTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAieyARKRTAKR--AGLMILTVW-TISIFISIPPLFWRNHH 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  189 SSNVSPACyedmgnnTANWRMLLRILPQSFG-FIVPLLIMLFCYgftLRTLFKAhmGQKHRAMRVIFAVVLIFLLCWLPY 267
Cdd:cd15335 143 DANIPSQC-------IIQHDHVIYTIYSTFGaFYIPLTLILILY---YRIYHAA--SRERKAARILGLILGAFILSWLPF 210
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4504683  268 nlvLLADTLMRTQVIQETCErrnhidrALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15335 211 ---FIKELIVGLSVMTVSPE-------VADFLTWLGYVNSLVNPLLYTSFNEDFK 255
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
220-325 1.03e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 43.63  E-value: 1.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  220 FIVPLLIMLFCYGFTLRTLFKAHMGQ---------KHRAMRVIFAVVLIFLLCWLPYnlvlladtlmRTQVIQETCERRN 290
Cdd:cd15082 186 FILPLGVIFVSYGKLLQKLRKVSNTQgrlgnarkpERQVTRMVVVMIVAFMVCWTPY----------AAFSILVTAHPTI 255
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 4504683  291 HIDRALDAT-EILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15082 256 HLDPRLAAIpAFFSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
220-325 1.34e-04

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 43.28  E-value: 1.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  220 FIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVI-------------FAVVLIFLLCWLPYNLVLLADTLMRTQVIQETC 286
Cdd:cd15078 170 LVVPLGIMAYCYGHILYEIRMLRSVEDLQTFQVIkilkyekkvakmcLLMISTFLICWMPYAVVSLLVTSGYSKLVTPTI 249
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 4504683  287 ERrnhidraldATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15078 250 AI---------IPSLFAKSSTAYNPVIYIFMIRKFRQCL 279
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
51-322 1.37e-04

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 43.22  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT---LPIWAASKVNGWIFGTFLCKVVSLLKE 127
Cdd:cd15358   3 VCVTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLgmpLELYEMWSNYPFLLGAGGCYFKTLLFE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRT-LTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNT-- 204
Cdd:cd15358  83 TVCFASILNVTALSVERYIAVVHPLKAkYVVTRTHAKRVIGAVWVVSILCSIPNTSLHGIFQLTVPCRGPVPDSATCMlv 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  205 ---ANWRMLLRILPQSFgFIVPLLIMLFCY--------------------GFTLRTLFKAHMGQKHRAMR----VIFAVV 257
Cdd:cd15358 163 kprWMYNLIIQITTLLF-FFLPMGTISVLYlliglqlkrekmllvleakgSKAGDSYQHRRIQQEKRRRRqvtkMLFVLV 241
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504683  258 LIFLLCWLPYNlvllADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15358 242 VVFGICWAPFH----TDRLMWSFISQWTGELHLAFQYVHIISGVFFYLSSAANPVLYNLMSTRFR 302
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
217-322 1.37e-04

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 43.13  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  217 SFGFIVPLLIMLFCYGFTL----------RTLFKAHMGQKH--------RAMRVIFAVVLIFLLCWLPYNLVLLadtlmr 278
Cdd:cd15104 166 CMVFFPALLLFVFCYCDILkiarvhsraiYKVEHALARQIHprrtlsdfKAARTVAVLIGCFLLSWLPFQITGL------ 239
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 4504683  279 tqvIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15104 240 ---VQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVR 280
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
49-325 1.48e-04

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 42.90  E-value: 1.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAA-SKVNGWIFGTFLCKVVSLLK 126
Cdd:cd15396   1 FLLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSdVLVCVMCIPFTAVyTLMDHWIFGETMCKLTSFVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIV----------HATR--TLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVsp 194
Cdd:cd15396  81 SVSVSVSIFSLVLIAIERYQLIVnprgwkpsasHAYWgiVLIWLFSLMISIPFLIFHQLTDEPFRNLSSHSDFYKDKV-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  195 ACYEDMGNNTAnwRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAH------------MGQKHRAMRVIFAVVLIFLL 262
Cdd:cd15396 159 VCIEAWPSETE--RLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNskidrmrenesrLSENKRINTMLISIVVTFAA 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504683  263 CWLPYNLVLLA-----DTLMrtqviqeTCerrnHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15396 237 CWLPLNIFNVVfdwnhEVLM-------SC----HHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQKDL 293
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
53-323 1.55e-04

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 43.03  E-value: 1.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSR----------VGRSVTDVyllnlaladLLFALTLPIWAASKVNG-WIFGTFLCKV 121
Cdd:cd15074   5 IYLTVIGILSTLGNGTVLFVLYRRRsklkpaelltVNLAVSDL---------GISVFGYPLAIISAFAHrWLFGDIGCVF 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  122 VSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGlslllalpVLLFRRTVYSSNVSPACYEDMG 201
Cdd:cd15074  76 YGFCGFLFGCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWL--------YALFWAVAPLVGWGSYGPEPFG 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  202 NN-TANWR--------MLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKH-------------RAMRVIFAVVLI 259
Cdd:cd15074 148 TScSIDWTgasasvggMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGfdsrskrqhkierKVTKVAVLICAG 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504683  260 FLLCWLPYNLVLLADTLmrtqviqetcerrNHIDRALDATEILGIL----HSCLNPLIYAFIGQKFRH 323
Cdd:cd15074 228 FLIAWTPYAVVSMWSAF-------------GSPDSVPILASILPALfaksSCMYNPIIYLLFSSKFRQ 282
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
52-322 1.59e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 42.92  E-value: 1.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLL---GNSLVMLVILYSRVGRSVTD-VYLLNLALADLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLK 126
Cdd:cd15316   1 VILYIVLGFGAVLavfGNLLVMISILHFKQLHSPTNfLIASLACADFLVGVTVMPFSTVRSVEScWYFGESFCTFHTCCD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSI-WglslllaLPVLLFRRTVYSSNVSPACYEDMGNN-- 203
Cdd:cd15316  81 VSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVsW-------IFSLTYSFSVFYTGVNDDGLEELVNAln 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  204 ---------TANWrmllrILPQSFGFIVPLLIMLFCYGFTLRTL--------------------FKAHMGQKHR-AMRVI 253
Cdd:cd15316 154 cvggcqiilNQNW-----VLVDFLLFFIPTFAMIILYGKIFLVAkqqarkiemtsskaesssesYKDRVARRERkAAKTL 228
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504683  254 FAVVLIFLLCWLPYNLVLLADTLMrtqviqetcerrNHIDRALdATEIL---GILHSCLNPLIYAFIGQKFR 322
Cdd:cd15316 229 GITVIAFLVSWLPYLIDVLIDAFM------------NFITPPY-IYEICcwcAYYNSAMNPLIYALFYPWFR 287
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
48-322 1.82e-04

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 42.47  E-value: 1.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   48 KYFVVIIYALVFLLSLLGNSLVMLVILYSR----------VGRSVTDVyllnlaladLLFALTLPIWAASKVNG-WIFGT 116
Cdd:cd15333   4 KISLAVLLALITLATTLSNAFVIATIYLTRklhtpanyliASLAVTDL---------LVSILVMPISIVYTVTGtWTLGQ 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  117 FLCKVvSLLKEVNF-YSGILLLACISVDRYLAIVHA---TRTLTQKRYLVKF-------ICLSIwglslllalpVLLFRR 185
Cdd:cd15333  75 VVCDI-WLSSDITCcTASILHLCVIALDRYWAITDAveySKKRTPKRAAVMIalvwvisISISL----------PPFFWR 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  186 TVYSSNVSPACyedmgnnTANWRMLLRILPQSFG-FIVPLLIMLFCYGftlrTLFKAHMGQKHRAMRVIFAVVLIFLLCW 264
Cdd:cd15333 144 QAKAEEEVSEC-------VVNTDHILYTVYSTVGaFYIPTLLLIALYG----RIYVEARARERKATKTLGIILGAFIVCW 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4504683  265 LPYNLVLLAdtlmrTQVIQETCERRNHIDralDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15333 213 LPFFIISLV-----LPICKDACWFHLAIF---DFFTWLGYLNSLINPIIYTMSNEDFK 262
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
50-322 2.23e-04

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 42.42  E-value: 2.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG--WIFGTFLCKVVSLLK 126
Cdd:cd15302   2 LLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIgLESMPFYTVYVLNGdyWPLGWVLCDLWLSVD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHAT-----RTLTQKRYLVKFICLSIWGLSLLLALPVLLFrrTVYSSNVSPA-CY-ED 199
Cdd:cd15302  82 YTVCLVSIYTVLLITIDRYCSVKIPAkyrnwRTPRKVLLIIAITWIIPALLFFISIFGWQYF--TGQGRSLPEGeCYvQF 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  200 MGNNTANWRMLLRIlpqsfgFIVPLLIMLFCYGFTLRTLFKAhmgqkHRAMRVIFAVVLIFLLCWLPYNLVLLadtlmrt 279
Cdd:cd15302 160 MTDPYFNMGMYIGY------YWTTLIVMLILYAGIYRAANRA-----RKALRTITFILGAFVICWTPYHILAT------- 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4504683  280 qvIQETCERRNHIDRAL-DATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15302 222 --IYGFCEAPPCVNETLyTISYYLCYMNSPINPFCYALANQQFK 263
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
50-314 2.26e-04

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 42.25  E-value: 2.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVT-DVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLK 126
Cdd:cd15328   2 LVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPhNLVASMAVSDVLVAALVMPLSLVHELSGrrWQLGRSLCQVWISFD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIV-HATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTA 205
Cdd:cd15328  82 VLCCTASIWNVTAIALDRYWSITrHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFGWGETYSEDSEECQVSQEPSYT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  206 nwrmllrILPQSFGFIVPLLIMLFCYGftlrTLFKAHMGQKHRAMRVIFaVVLIFLLCWLPYNLvlladtlmrTQVIQET 285
Cdd:cd15328 162 -------VFSTFGAFYLPLCVVLFVYW----KIYKAAQKEKRAALMVGI-LIGVFVLCWIPFFL---------TELISPL 220
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4504683  286 CerrnhidrALDATEI-------LGILHSCLNPLIY 314
Cdd:cd15328 221 C--------SCDIPPIwksiflwLGYSNSFFNPLIY 248
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
53-272 2.31e-04

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 42.51  E-value: 2.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   53 IIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG--WIFGTFLCKVVSLLKEVNF 130
Cdd:cd15008   4 LVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSgrWTLGSAMCKLVRYFQYLTP 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  131 YSGILLLACISVDRYLAIVHATrTLTQKRYLVKFICLSIWGLSLLLALPVLLFrrtvYSSNVSPACYEDMGNntaNWR-M 209
Cdd:cd15008  84 GVQIYVLLSICVDRFYTIVYPL-SFKVSREKAKKMIAASWLFDAAFVSPALFF----YGSNWGPHCNFFLPD---SWDgA 155
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504683  210 LLRILPQSFGFIVP-LLIMLFCY------------GFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLL 272
Cdd:cd15008 156 AYAIIHLLVGFLVPsILIILFYQkvikyiwrigtdGRTVRRTMNIVPRTKVKTIKMFLMLNSMFLLSWLPFYVVQL 231
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
49-317 2.38e-04

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 42.45  E-value: 2.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV--NGWIFGTFLCKVVSLLK 126
Cdd:cd15398   1 YFLIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVllDQWIFGEVMCHIVPFLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  127 EVNFYSGILLLACISVDRYLAIVHA-TRTLTQKRYLvkFICLSIWGLSLLLALPVLLFRRTVYSSNVSPA--------CY 197
Cdd:cd15398  81 CVSVMVSTLMLMSIAIVRYHMIKHPlSNHLTANHGY--FLLGTVWTLGFTICSPLPVFHKIVDLSETFNLeslknkylCI 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  198 EDMGNNTanWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLfkahmgqkHRAMRVIF---AVVLIFLLCWLPYNLVLLAD 274
Cdd:cd15398 159 ESWPSDS--YRIAFTISLLFVQYILPLVCLTVSHTSVCRSV--------KRSRSVFYrltIVILAFAVSWMPLHLFHLVT 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4504683  275 TLMRTQViqetceRRNHIDRALDATEILGILHSCLNPLIYAFI 317
Cdd:cd15398 229 DFNANLI------SNRHFKLVYCICHLLGMLSCCLNPILYGFL 265
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
50-276 2.57e-04

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 42.26  E-value: 2.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKE 127
Cdd:cd15297   2 FIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIgVFSMNLYTLYTVIGyWPLGPVVCDLWLALDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHA-TRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSP--ACYEDMGNNT 204
Cdd:cd15297  82 VVSNASVMNLLIISFDRYFCVTKPlTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRTVPegECYIQFFSNA 161
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504683  205 AnwrmllrilpQSFG-----FIVPLLIMLFCYGFTLRTlfkahMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd15297 162 A----------VTFGtaiaaFYLPVIIMTVLYWQISRA-----SSREKKVTRTILAILLAFIITWTPYNVMVLINTF 223
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
56-316 2.78e-04

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 42.30  E-value: 2.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   56 ALVFLLSLLGNSLVMLVILYSRVGRS-VTDVYLLNLALADLLFALTLPIW-AASKVNG-WIFGTFlCKVVSLLKEVNFYS 132
Cdd:cd15320   9 SVLILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWkAVAEIAGfWPFGSF-CNIWVAFDIMCSTA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  133 GILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSI-WGLSLLLALPVLLF-----RRTVYSSNVSPACYEDMGNNTAN 206
Cdd:cd15320  88 SILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVaWTLSVLISFIPVQLnwhkaKPTSFLDLNASLRDLTMDNCDSS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  207 WRMLLRILPQSFGFIVPLLIMLFCYGFTLR--------------------------------------TLFKAHMGQKHR 248
Cdd:cd15320 168 LNRTYAISSSLISFYIPVAIMIVTYTRIYRiaqkqirrisaleraavhakncqnstgnrgsgdcqqpeSSFKMSFKRETK 247
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504683  249 AMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNhidrALDATEILGILHSCLNPLIYAF 316
Cdd:cd15320 248 VLKTLSVIMGVFVCCWLPFFILNCMVPFCKPTSTEPFCISST----TFDVFVWFGWANSSLNPIIYAF 311
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
52-316 3.26e-04

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 42.06  E-value: 3.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   52 VIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKV---NGWIFGTFLCKVVSLLKEV 128
Cdd:cd15212   4 ALVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLfsrPGWLFGDRLCLANGFFNAC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  129 NFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFIcLSIWglslllaLPVLLFRRTVYSSNVSPACYEDMGNNTANWR 208
Cdd:cd15212  84 FGIVSTLTMTLISFDRYYAIVRQPQGKIGRRRALQLL-AAAW-------LTALGFSLPWYLLASAPEYYEKLGFYHCLYV 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  209 mlLRILPQSFG-----------FIVPLLIMLFC--------------------YGFTLRtlFKAHMgqkhRAMRVIFAVV 257
Cdd:cd15212 156 --LHSGPSRLGaayssvlivlcYLLPFALMCFChynicktvrlsesrvrpvttYAHLLR--FYSEM----RTATTVLIMI 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  258 LIFLLCWLPYNLVLLADTLMRTQviqetcerrnhIDRALDATEILGILHSC-LNPLIYAF 316
Cdd:cd15212 228 VFIICCWGPYCLLGLVAAAGGYQ-----------FPPLMDTVAIWMAWANGaINPLIYAI 276
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
217-322 5.46e-04

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 41.35  E-value: 5.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  217 SFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRA---------MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQEtce 287
Cdd:cd15077 172 CFCFGVPLSIIVFSYGRLLLTLRAVAKQQEQSAstqkaerevTKMVVVMVLGFLVCWLPYASFALWVVTNRGEPFDL--- 248
                        90       100       110
                ....*....|....*....|....*....|....*
gi 4504683  288 rrnhidRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15077 249 ------RLASIPSVFSKASTVYNPVIYVFMNKQFR 277
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
50-322 6.44e-04

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 40.77  E-value: 6.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKE 127
Cdd:cd15298   2 FIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIgAFSMNLYTVYIIKGyWPLGAVVCDLWLALDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIV----HATRTLTQkryLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPA--CYEDMG 201
Cdd:cd15298  82 VVSNASVMNLLIISFDRYFCVTkpltYPARRTTK---MAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDnqCFIQFL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  202 NNTAnwrmllrilpQSFG-----FIVPLLIMLFCYgftlrTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd15298 159 SNPA----------VTFGtaiaaFYLPVVIMTVLY-----IHISLASARERKVTRTIFAILLAFILTWTPYNVMVLVNTF 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4504683  277 MRTQViqetcerrnhIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15298 224 CQSCI----------PDTVWSIGYWLCYVNSTINPACYALCNATFK 259
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
51-322 7.00e-04

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 40.99  E-value: 7.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   51 VVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDV----YLLNLALADLLFALTLPIWAASKV---NGWIFGTFLCKVVS 123
Cdd:cd15355   3 VTAIYLALFVVGTVGNSITLYTLARKKSLQHLQSTvhyhLASLALSDLLILLLAMPVELYNFIwvhHPWAFGDAACRGYY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  124 LLKEVNFYSGILLLACISVDRYLAIVHATR--TLTQKRYLVKFIcLSIWGLSLLLALPVLLFRRTVYSSNVSPA---CYE 198
Cdd:cd15355  83 FLRDACTYATALNVASLSVERYLAICHPFKakSLMSRSRTKKFI-SAIWLASALLAIPMLFTMGEQNRSGTHPGgliCTP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  199 DMGNNTANWRMLLRILpqsFGFIVPLLIM----------------------LFCYGFTLRTLFKAHMGQKH-----RAMR 251
Cdd:cd15355 162 IVDTSTLKVVIQVNAF---LSFLFPMLVIsvlntlianqltvmvnqaeqenQVCTIGGQRTVLSVSMEPGRvqslrHGVL 238
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504683  252 VIFAVVLIFLLCWLPYNlvllADTLMRTQVIQE--TCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15355 239 VLRAVVIAFVVCWLPYH----VRRLMFCYVSDEqwTTFLYDFYHYFYMLTNVLFYVSSAINPILYNLVSANFR 307
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
50-322 7.58e-04

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 40.75  E-value: 7.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLF-ALTLPIWAASKVNG-WIFGTFLCKVVSLLKE 127
Cdd:cd15048   2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVgLVSMPFYIPYTLTGkWPFGKVFCKAWLVVDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHA----TRTLTQKRYL---VKFICLSIWGLSLLLALPVLLFRRTVYSSNvspaCYEDM 200
Cdd:cd15048  82 TLCTASALTIVLISLDRYLSVTKAvkyrAKQTKRRTVLlmaLVWILAFLLYGPAIIGWDLWTGYSIVPTGD----CEVEF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  201 gnnTANWRMLLriLPQSFGFIVPLLIMLFCY------------------------------GFTLRTLFKahMGQKHRAM 250
Cdd:cd15048 158 ---FDHFYFTF--ITSVLEFFIPFISVSFFNlliylnirkrsrrrplrsvpilpasqnpsrARSQREQVK--LRRDRKAA 230
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504683  251 RVIFAVVLIFLLCWLPYNLVlladTLMRTQviqetCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFR 322
Cdd:cd15048 231 KSLAILVLVFLICWAPYTIL----TIIRSF-----CSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFR 293
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
57-150 8.72e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 40.90  E-value: 8.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   57 LVFLLSLLGNSLVMLVILYSR-VGRSVTDVYLLNLALADLLFALTLPIWAASKVN--GWIFGTFLCKVVSLLKEVNFYSG 133
Cdd:cd15005   9 LILCVSLAGNLLFSVLIVRDRsLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHgsGWIYGALSCKVIAFLAVLFCFHS 88
                        90
                ....*....|....*..
gi 4504683  134 ILLLACISVDRYLAIVH 150
Cdd:cd15005  89 AFTLFCIAVTRYMAIAH 105
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
49-150 1.09e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 40.70  E-value: 1.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAASKVNG--WIFGTFLCKVVSLL 125
Cdd:cd15217   1 YVKLVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLAdTIRSAVCFPFVLVSIRNGsaWTYSVLSCKIVAFM 80
                        90       100
                ....*....|....*....|....*
gi 4504683  126 KEVNFYSGILLLACISVDRYLAIVH 150
Cdd:cd15217  81 AVLFCFHAAFMLFCISVTRYMAIAH 105
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
220-267 1.31e-03

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 40.20  E-value: 1.31e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504683  220 FIVPLLIMLFCYGFTLRTLFKAHMGQKHRA---------MRVIFAVVLIFLLCWLPY 267
Cdd:cd15080 175 FTIPLIVIFFCYGRLVCTVKEAAAQQQESAttqkaekevTRMVIIMVIAFLICWVPY 231
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
118-323 1.53e-03

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 39.88  E-value: 1.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  118 LCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLAL---PVLLFRRTVYSSN--- 191
Cdd:cd15137  79 LCTFAGFLATLSSEVSVLILTLITLDRFICIVFPFSGRRLGLRRAIIVLACIWLIGLLLAVlplLPWDYFGNFYGRSgvc 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  192 -------VSPACYED-----MGNNTAnwrmllrilpqSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAM-RVIFAVVL 258
Cdd:cd15137 159 lplhitdERPAGWEYsvfvfLGLNFL-----------AFVFILLSYIAMFISIRRTRKAAASRKSKRDMAVaKRFFLIVL 227
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504683  259 IFLLCWLPYNLVLLAdTLMRTQVIQETcerrnhidRALDATEILGIlHSCLNPLIYAFIGQKFRH 323
Cdd:cd15137 228 TDFLCWIPIIVIGIL-ALSGVPIPGEV--------YAWVAVFVLPI-NSALNPILYTLSTPKFRK 282
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
56-162 1.86e-03

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 39.94  E-value: 1.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   56 ALVFLLSLLGNSLVMLVILYSRVGRS-VTDVYLLNLALADLLFALTLPIW-AASKVNG-WIFGTFlCKVVSLLKEVNFYS 132
Cdd:cd15319   8 SLLILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVMPWkAVAEVAGyWPFGAF-CDVWVAFDIMCSTA 86
                        90       100       110
                ....*....|....*....|....*....|...
gi 4504683  133 GILLLACISVDRYLAI---VHATRTLTQKRYLV 162
Cdd:cd15319  87 SILNLCVISVDRYWAIsspFRYERKMTQRVALV 119
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
112-150 2.02e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 39.63  E-value: 2.02e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 4504683  112 WIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVH 150
Cdd:cd15218  67 WTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRYLAIAH 105
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
57-276 3.61e-03

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 38.59  E-value: 3.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   57 LVFLLSLLGNSLVMLVILYSRVGRS-VTDVYLLNLALADLLFALT-LPIWAASKV-NGWIFGTFLCKVVSLLKEVNFYSG 133
Cdd:cd15219   8 VVLVVSLLSNLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLTVLnMPFTLLGVVrNRQPFGDGFCQAVGFLETFLTSNA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  134 ILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSI-WGLSLLLALPVLLFRRTVYSSnVSPACYEDMGNNTANWR-MLL 211
Cdd:cd15219  88 MLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYsWLHSLTFSLVALFLSWLGYSS-LYASCTLHLPREEERRRfAVF 166
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504683  212 RILPQSFGFIVPLLIMLFCYGFTLRtlfkahMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL 276
Cdd:cd15219 167 TAFFHAFTFLLSLLVLCVTYLKVLK------VRRRQRATKKISIFIGTFVLCFAPYVITRLVELL 225
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
49-269 3.71e-03

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 38.62  E-value: 3.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   49 YFVVIIYALVFLLSLLGnSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNG-WIFGTFLCKVVSLLKE 127
Cdd:cd14994   2 YSLIFLYSVVLIGGVIG-VILMSFLLVKMNTRSVTTTAVINLIVVHSLFLLTVPFRIYYYASKtWKFGMPLCKMVSAMIH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  128 VNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKF-ICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYE---DMGNN 203
Cdd:cd14994  81 IHMHLTFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVaASAVVWVLVLLIVVPVFVKEYGSSSSYNSDQCFKfhkELEVH 160
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504683  204 TA---NWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIflLCWLPYNL 269
Cdd:cd14994 161 YVkvlNYIIICIVLIVTLALLGFQVFILGHVYRKLRASLLSHQEFWAQMKSLFFIVVII--VCFVPYNL 227
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
248-325 4.50e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 38.22  E-value: 4.50e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504683  248 RAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQviqeTCErrnhIDRALDATEILGILHSCLNPLIYAFIGQKFRHGL 325
Cdd:cd15102 201 ALLKTVLIVLLVFIACWGPLFILLLLDVACPVK----TCP----ILYKADWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
50-322 6.28e-03

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 38.24  E-value: 6.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683   50 FVVIIYALVFLLSLLGNSLVMLV--ILYSR--VGRSVTDVYLLNLALADLLFALTLP------IWaasKVNGWIFGTFLC 119
Cdd:cd15135   2 TLTLLYSLILVAGILGNSATIKVtqVLQKKgyLQKSVTDHMVSLACSDLLVLLLGMPvelysaIW---DPFATPSGNIAC 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  120 KVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVY-------SSNV 192
Cdd:cd15135  79 KIYNFLFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLICFVWLTSALVALPLLFAMGTEDpleafpsYRGT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  193 SPACYEDMGNNT------ANWRMLLRILpqsFGFIVPLLIMLFCYGFTLRTLFKAHM------------GQKHRAMR--- 251
Cdd:cd15135 159 RHHCQDQKSNLTictslsSKWTVFQASI---FSAFVLYLLVLASVAFMCRRMMRALMgskkgavavkgpGGSVQLLRkhe 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  252 -----------VIF--AVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIdrALDATEILGILHSCLNPLIYAFIG 318
Cdd:cd15135 236 saegktarkqtILFlgLIVGTLAVCWMPNQIRRIMAAAKPKDDWTRSYFRAYII--LLPIADTFFYLSSVLNPLLYNLSS 313

                ....
gi 4504683  319 QKFR 322
Cdd:cd15135 314 QQFR 317
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
218-322 7.39e-03

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 37.87  E-value: 7.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504683  218 FGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAM---------RVIFAVVLIFLLCWLPYnlvllADTLMRtqviqeTCER 288
Cdd:cd15076 173 FCFIVPLSIIIFSYSQLLGALRAVAAQQQESAStqkaerevsRMVVVMVGSFCLCYVPY-----AALAMY------MVNN 241
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 4504683  289 RNH-IDRALDATEILGILHSCL-NPLIYAFIGQKFR 322
Cdd:cd15076 242 RDHgLDLRLVTIPAFFSKSSCVyNPIIYCFMNKQFR 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH