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Conserved domains on  [gi|4504647|ref|NP_001551|]
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interleukin-13 receptor subunit alpha-1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Il13Ra_Ig pfam18001
Interleukin-13 receptor subunit alpha Ig-like domain; This is the N-terminal Ig-like domain ...
 31-125 2.84e-52

Interleukin-13 receptor subunit alpha Ig-like domain; This is the N-terminal Ig-like domain found in IL-13Ralpha1 type two cytokine complex. The IL-13Ralpha1 contains an extra N-terminal Ig-like domain not found in other receptors of the the common gamma-chain subfamily. The extra N-terminal IL-13Ralpha1 Ig-like domain contacts the dorsal surfaces of both IL-4 and IL-13. Mutational studies show that the deletion of this domain affects the binding of IL-13 to IL-13Ralpha1.


:

Pssm-ID: 465611  Cd Length: 95  Bit Score: 170.39  E-value: 2.84e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504647     31 TQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKP 110
Cdd:pfam18001   1 VLPPPSNLSYSVKQLCTLKWTWNPPEGVSSSCSLEYFSHIGPQENREWSKNTFREEEVPLNEEICLQVRSQCKMNESEKP 80

                          90
                  ....*....|....*
gi 4504647    111 SILVEKCISPPEGDP 125
Cdd:pfam18001  81 SDLVEKCISPPEGDP 95
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 131-224 2.41e-36

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


:

Pssm-ID: 401252  Cd Length: 96  Bit Score: 128.68  E-value: 2.41e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504647    131 ELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCEN-IFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDN 209
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYyIRDDGTRIGCQFDDLEGLSSSFHQVYICVNGSSS 80

                          90
                  ....*....|....*
gi 4504647    210 AGKIKPSFNIVPLTS 224
Cdd:pfam09240  81 AGPIRSSDQTFQLQN 95
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 228-336 2.92e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.71  E-value: 2.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504647  228 PDPPHikNLSFHN---DDLYVQWENPQNFISRCLFYEVEVNNSQTETHNvfyvqeakcenpEFERNVENTSCFMVPGVLP 304
Cdd:cd00063   1 PSPPT--NLRVTDvtsTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWK------------EVEVTPGSETSYTLTGLKP 66

                        90       100       110
                ....*....|....*....|....*....|..
gi 4504647  305 DTLNTVRIRVKTnklcyedDKLWSNWSQEMSI 336
Cdd:cd00063  67 GTEYEFRVRAVN-------GGGESPPSESVTV 91
 
Name Accession Description Interval E-value
Il13Ra_Ig pfam18001
Interleukin-13 receptor subunit alpha Ig-like domain; This is the N-terminal Ig-like domain ...
 31-125 2.84e-52

Interleukin-13 receptor subunit alpha Ig-like domain; This is the N-terminal Ig-like domain found in IL-13Ralpha1 type two cytokine complex. The IL-13Ralpha1 contains an extra N-terminal Ig-like domain not found in other receptors of the the common gamma-chain subfamily. The extra N-terminal IL-13Ralpha1 Ig-like domain contacts the dorsal surfaces of both IL-4 and IL-13. Mutational studies show that the deletion of this domain affects the binding of IL-13 to IL-13Ralpha1.


Pssm-ID: 465611  Cd Length: 95  Bit Score: 170.39  E-value: 2.84e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504647     31 TQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKP 110
Cdd:pfam18001   1 VLPPPSNLSYSVKQLCTLKWTWNPPEGVSSSCSLEYFSHIGPQENREWSKNTFREEEVPLNEEICLQVRSQCKMNESEKP 80

                          90
                  ....*....|....*
gi 4504647    111 SILVEKCISPPEGDP 125
Cdd:pfam18001  81 SDLVEKCISPPEGDP 95
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 131-224 2.41e-36

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 128.68  E-value: 2.41e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504647    131 ELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCEN-IFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDN 209
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYyIRDDGTRIGCQFDDLEGLSSSFHQVYICVNGSSS 80

                          90
                  ....*....|....*
gi 4504647    210 AGKIKPSFNIVPLTS 224
Cdd:pfam09240  81 AGPIRSSDQTFQLQN 95
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 228-336 2.92e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.71  E-value: 2.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504647  228 PDPPHikNLSFHN---DDLYVQWENPQNFISRCLFYEVEVNNSQTETHNvfyvqeakcenpEFERNVENTSCFMVPGVLP 304
Cdd:cd00063   1 PSPPT--NLRVTDvtsTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWK------------EVEVTPGSETSYTLTGLKP 66

                        90       100       110
                ....*....|....*....|....*....|..
gi 4504647  305 DTLNTVRIRVKTnklcyedDKLWSNWSQEMSI 336
Cdd:cd00063  67 GTEYEFRVRAVN-------GGGESPPSESVTV 91
 
Name Accession Description Interval E-value
Il13Ra_Ig pfam18001
Interleukin-13 receptor subunit alpha Ig-like domain; This is the N-terminal Ig-like domain ...
 31-125 2.84e-52

Interleukin-13 receptor subunit alpha Ig-like domain; This is the N-terminal Ig-like domain found in IL-13Ralpha1 type two cytokine complex. The IL-13Ralpha1 contains an extra N-terminal Ig-like domain not found in other receptors of the the common gamma-chain subfamily. The extra N-terminal IL-13Ralpha1 Ig-like domain contacts the dorsal surfaces of both IL-4 and IL-13. Mutational studies show that the deletion of this domain affects the binding of IL-13 to IL-13Ralpha1.


Pssm-ID: 465611  Cd Length: 95  Bit Score: 170.39  E-value: 2.84e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504647     31 TQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKP 110
Cdd:pfam18001   1 VLPPPSNLSYSVKQLCTLKWTWNPPEGVSSSCSLEYFSHIGPQENREWSKNTFREEEVPLNEEICLQVRSQCKMNESEKP 80

                          90
                  ....*....|....*
gi 4504647    111 SILVEKCISPPEGDP 125
Cdd:pfam18001  81 SDLVEKCISPPEGDP 95
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 131-224 2.41e-36

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 128.68  E-value: 2.41e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504647    131 ELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCEN-IFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDN 209
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYyIRDDGTRIGCQFDDLEGLSSSFHQVYICVNGSSS 80

                          90
                  ....*....|....*
gi 4504647    210 AGKIKPSFNIVPLTS 224
Cdd:pfam09240  81 AGPIRSSDQTFQLQN 95
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 228-336 2.92e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.71  E-value: 2.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504647  228 PDPPHikNLSFHN---DDLYVQWENPQNFISRCLFYEVEVNNSQTETHNvfyvqeakcenpEFERNVENTSCFMVPGVLP 304
Cdd:cd00063   1 PSPPT--NLRVTDvtsTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWK------------EVEVTPGSETSYTLTGLKP 66

                        90       100       110
                ....*....|....*....|....*....|..
gi 4504647  305 DTLNTVRIRVKTnklcyedDKLWSNWSQEMSI 336
Cdd:cd00063  67 GTEYEFRVRAVN-------GGGESPPSESVTV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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