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Conserved domains on  [gi|6631090|ref|NP_001554|]
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interphotoreceptor matrix proteoglycan 1 isoform 1 precursor [Homo sapiens]

Protein Classification

SEA domain-containing protein( domain architecture ID 10475853)

SEA (found in Sea urchin sperm protein, Enterokinase, Agrin) domain-containing protein similar to vertebrate interphotoreceptor matrix proteoglycan 1 and human membrane mucins (mucin-12, -16 and -17)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 574-659 6.21e-13

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


:

Pssm-ID: 460188  Cd Length: 100  Bit Score: 65.34  E-value: 6.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6631090    574 VVFFSLRVANMAFSNDLFNKSSLEYRALEQQFTQLLVPYLR-SNL-TGFKQLEILNFR--NGSVIVNSKMKFAKSV---P 646
Cdd:pfam01390   2 YYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRnSSLrKQYIKSHVLRLRpdGGSVVVDVVLVFRFPStepA 81

                          90
                  ....*....|...
gi 6631090    647 YNLTKAVHGVLED 659
Cdd:pfam01390  82 LDREKLIEEILRQ 94
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 234-292 3.75e-07

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


:

Pssm-ID: 460188  Cd Length: 100  Bit Score: 48.77  E-value: 3.75e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6631090    234 QRVELSVSLVNQKFKAELADSQSPYYQELAGKSQLQMQKIFKK---LPGFKKIHVLGFRPKK 292
Cdd:pfam01390   1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNsslRKQYIKSHVLRLRPDG 62
 
Name Accession Description Interval E-value
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 574-659 6.21e-13

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 65.34  E-value: 6.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6631090    574 VVFFSLRVANMAFSNDLFNKSSLEYRALEQQFTQLLVPYLR-SNL-TGFKQLEILNFR--NGSVIVNSKMKFAKSV---P 646
Cdd:pfam01390   2 YYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRnSSLrKQYIKSHVLRLRpdGGSVVVDVVLVFRFPStepA 81

                          90
                  ....*....|...
gi 6631090    647 YNLTKAVHGVLED 659
Cdd:pfam01390  82 LDREKLIEEILRQ 94
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 573-660 5.58e-11

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 60.50  E-value: 5.58e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6631090     573 LVVFFSLRVANMAFSNDLFNKSSLEYRALEQQFTQLLVPYLRSNLT--GFKQLEILNFRNGSVIVNSKMKFAKSVPynlt 650
Cdd:smart00200   8 SLSVLSVEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTDLkpDFVGTEVIEFRNGSVVVDLGLLFNEGVT---- 83

                           90
                   ....*....|
gi 6631090     651 kAVHGVLEDF 660
Cdd:smart00200  84 -NGQDVEEDL 92
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 234-292 3.75e-07

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 48.77  E-value: 3.75e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6631090    234 QRVELSVSLVNQKFKAELADSQSPYYQELAGKSQLQMQKIFKK---LPGFKKIHVLGFRPKK 292
Cdd:pfam01390   1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNsslRKQYIKSHVLRLRPDG 62
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 232-290 9.78e-04

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 39.70  E-value: 9.78e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6631090     232 EEQRVELSVSLV-----NQKFKAELADSQSPYYQELAGKSQLQMQKIFKKL---PGFKKIHVLGFRP 290
Cdd:smart00200   1 PTQSFGVSLSVLsvegeNLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTdlkPDFVGTEVIEFRN 67
 
Name Accession Description Interval E-value
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 574-659 6.21e-13

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 65.34  E-value: 6.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6631090    574 VVFFSLRVANMAFSNDLFNKSSLEYRALEQQFTQLLVPYLR-SNL-TGFKQLEILNFR--NGSVIVNSKMKFAKSV---P 646
Cdd:pfam01390   2 YYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRnSSLrKQYIKSHVLRLRpdGGSVVVDVVLVFRFPStepA 81

                          90
                  ....*....|...
gi 6631090    647 YNLTKAVHGVLED 659
Cdd:pfam01390  82 LDREKLIEEILRQ 94
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 573-660 5.58e-11

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 60.50  E-value: 5.58e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6631090     573 LVVFFSLRVANMAFSNDLFNKSSLEYRALEQQFTQLLVPYLRSNLT--GFKQLEILNFRNGSVIVNSKMKFAKSVPynlt 650
Cdd:smart00200   8 SLSVLSVEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTDLkpDFVGTEVIEFRNGSVVVDLGLLFNEGVT---- 83

                           90
                   ....*....|
gi 6631090     651 kAVHGVLEDF 660
Cdd:smart00200  84 -NGQDVEEDL 92
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 234-292 3.75e-07

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 48.77  E-value: 3.75e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6631090    234 QRVELSVSLVNQKFKAELADSQSPYYQELAGKSQLQMQKIFKK---LPGFKKIHVLGFRPKK 292
Cdd:pfam01390   1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRNsslRKQYIKSHVLRLRPDG 62
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 232-290 9.78e-04

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 39.70  E-value: 9.78e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6631090     232 EEQRVELSVSLV-----NQKFKAELADSQSPYYQELAGKSQLQMQKIFKKL---PGFKKIHVLGFRP 290
Cdd:smart00200   1 PTQSFGVSLSVLsvegeNLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTdlkPDFVGTEVIEFRN 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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