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Conserved domains on  [gi|156523970|ref|NP_001613|]
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alpha-2-HS-glycoprotein isoform 2 preproprotein [Homo sapiens]

Protein Classification

CY domain-containing protein( domain architecture ID 11249389)

CY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-133 8.94e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 58.21  E-value: 8.94e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523970    31 NCDDPETEEAALVAIDYINQNLpwGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPvARCSVRQLKehav 110
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQG---- 82

                           90       100
                   ....*....|....*....|....*
gi 156523970   111 EGDCDFQLLKLDG--KFSVVYAKCD 133
Cdd:smart00043  83 EKFCTAKVWEKPWenKIKLVEFKCT 107
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 149-233 3.90e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member pfam00031:

Pssm-ID: 447698  Cd Length: 92  Bit Score: 53.11  E-value: 3.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523970  149 CPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTY-VEFTVSGTDCVaKEATEAAKCNLLAEKQY 227
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80


                  ....*.
gi 156523970  228 GFCKAT 233
Cdd:pfam00031  81 GLCSAQ 86
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-133 8.94e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 58.21  E-value: 8.94e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523970    31 NCDDPETEEAALVAIDYINQNLpwGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPvARCSVRQLKehav 110
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQG---- 82

                           90       100
                   ....*....|....*....|....*
gi 156523970   111 EGDCDFQLLKLDG--KFSVVYAKCD 133
Cdd:smart00043  83 EKFCTAKVWEKPWenKIKLVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 149-233 3.90e-09

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 53.11  E-value: 3.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523970  149 CPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTY-VEFTVSGTDCVaKEATEAAKCNLLAEKQY 227
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80


                  ....*.
gi 156523970  228 GFCKAT 233
Cdd:pfam00031  81 GLCSAQ 86
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 28-120 3.13e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 48.24  E-value: 3.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523970  28 RQPNCDDPETEEAALVAIDYINQNLpwgyKHTLNQIDEV-KVWPQQPSGELFEIEIDTLETTCHVLDPTPVarCSVRQLK 106
Cdd:cd00042    4 SDIPANDPEVQELADFAVAEYNKKS----NDKYLEFFKVlSAKSQVVAGTNYYITVEAGDTNCKKSSVPLD--CPDCKLL 77

                         90
                 ....*....|....
gi 156523970 107 EHAVEGDCDFQLLK 120
Cdd:cd00042   78 EEGKKKFCTAKVWE 91
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 146-247 1.01e-06

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 46.65  E-value: 1.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523970   146 CQDCPLLAPLNDTRVVHAAKAALAAFnaqNNGSN--FQLEEISRA---QLVPLPPSTYVEFTVSGTDCVaKEATEAAKCN 220
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEY---NKKSNdkYELRVIKVVsakSQVVAGTNYYLKVEVGETNCK-KLSVDLENCP 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 156523970   221 LLAEKQyGFCKATLSEKLG---GAEVAVTC 247
Cdd:smart00043  78 FLDQGE-KFCTAKVWEKPWenkIKLVEFKC 106
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 148-247 1.54e-06

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 46.31  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523970 148 DCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRA--QLVplpPSTYVEFTVSGTDCVAKEA---TEAAKCNLL 222
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAksQVV---AGTNYYITVEAGDTNCKKSsvpLDCPDCKLL 77

                         90       100
                 ....*....|....*....|....*...
gi 156523970 223 AEKQYGFCKATLSEKL---GGAEVAVTC 247
Cdd:cd00042   78 EEGKKKFCTAKVWEKPwenFKELLSFKC 105
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 31-133 8.94e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 58.21  E-value: 8.94e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523970    31 NCDDPETEEAALVAIDYINQNLpwGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPvARCSVRQLKehav 110
Cdd:smart00043  10 PPNDPEVQEAADFAVAEYNKKS--NDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQG---- 82

                           90       100
                   ....*....|....*....|....*
gi 156523970   111 EGDCDFQLLKLDG--KFSVVYAKCD 133
Cdd:smart00043  83 EKFCTAKVWEKPWenKIKLVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 149-233 3.90e-09

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 53.11  E-value: 3.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523970  149 CPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTY-VEFTVSGTDCVaKEATEAAKCNLLAEKQY 227
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80


                  ....*.
gi 156523970  228 GFCKAT 233
Cdd:pfam00031  81 GLCSAQ 86
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 28-120 3.13e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 48.24  E-value: 3.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523970  28 RQPNCDDPETEEAALVAIDYINQNLpwgyKHTLNQIDEV-KVWPQQPSGELFEIEIDTLETTCHVLDPTPVarCSVRQLK 106
Cdd:cd00042    4 SDIPANDPEVQELADFAVAEYNKKS----NDKYLEFFKVlSAKSQVVAGTNYYITVEAGDTNCKKSSVPLD--CPDCKLL 77

                         90
                 ....*....|....
gi 156523970 107 EHAVEGDCDFQLLK 120
Cdd:cd00042   78 EEGKKKFCTAKVWE 91
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 146-247 1.01e-06

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 46.65  E-value: 1.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523970   146 CQDCPLLAPLNDTRVVHAAKAALAAFnaqNNGSN--FQLEEISRA---QLVPLPPSTYVEFTVSGTDCVaKEATEAAKCN 220
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEY---NKKSNdkYELRVIKVVsakSQVVAGTNYYLKVEVGETNCK-KLSVDLENCP 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 156523970   221 LLAEKQyGFCKATLSEKLG---GAEVAVTC 247
Cdd:smart00043  78 FLDQGE-KFCTAKVWEKPWenkIKLVEFKC 106
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 148-247 1.54e-06

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 46.31  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523970 148 DCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRA--QLVplpPSTYVEFTVSGTDCVAKEA---TEAAKCNLL 222
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAksQVV---AGTNYYITVEAGDTNCKKSsvpLDCPDCKLL 77

                         90       100
                 ....*....|....*....|....*...
gi 156523970 223 AEKQYGFCKATLSEKL---GGAEVAVTC 247
Cdd:cd00042   78 EEGKKKFCTAKVWEKPwenFKELLSFKC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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