NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4502181|ref|NP_001641|]
View 

aquaporin-4 isoform M1 [Homo sapiens]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 31-248 7.00e-84

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 252.62  E-value: 7.00e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181     31 TQAFWKAVTAEFLAMLIFVLLSLGSTINWGG-TEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 109
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKlVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    110 ISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 189
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    190 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 248
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 31-248 7.00e-84

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 252.62  E-value: 7.00e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181     31 TQAFWKAVTAEFLAMLIFVLLSLGSTINWGG-TEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 109
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKlVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    110 ISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 189
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    190 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 248
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 36-251 4.18e-73

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 225.21  E-value: 4.18e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   36 KAVTAEFLAMLIFVLLSLGSTINWGGTEKpLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 115
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG-ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181  116 VFYIAAQCLGAIIGAGILYLVTPPSVVGGLGV---------TMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVT 186
Cdd:cd00333  80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGAnnivagifgTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPP 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502181  187 GSIA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGN---WENHWIYWVGPIIGAVLAGGLYEYV 251
Cdd:cd00333 160 GGLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 40-248 4.51e-67

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 209.46  E-value: 4.51e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181     40 AEFLAMLIFVLLSLGSTI---NWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSV 116
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    117 FYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGN-LTAGHGLLVELIITFQLVFTIFASCD-SKRTDVTGSIALAIG 194
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4502181    195 FSVAIGHLFAINYTGASMNPARSFGPAVI--MGNWENHWIYWVGPIIGAVLAGGLY 248
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFagLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 34-252 4.78e-61

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 194.58  E-value: 4.78e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   34 FWKAVTAEFLAMLIFVLLSLGSTINWGGTekPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 113
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVAVLAGT--KGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181  114 KSVFYIAAQCLGAIIGAGILYLV--------TPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDv 185
Cdd:COG0580  80 DVLPYIIAQLLGAFLGAALVYLIygghfdatEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAP- 158

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502181  186 TGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIM------GNWENHWIYWVGPIIGAVLAGGLYEYVF 252
Cdd:COG0580 159 GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 36-252 2.82e-44

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 152.01  E-value: 2.82e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    36 KAVTAEFLAMLIFVLLSLGSTINWGG--TEKPL-PVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 112
Cdd:PLN00166  19 KAYLSEFIATLLFVFAGVGSAIAFAKltSDAALdPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   113 AKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTmvhGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-L 191
Cdd:PLN00166  99 ITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVA---AGLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIApI 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502181   192 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 252
Cdd:PLN00166 176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 31-248 7.00e-84

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 252.62  E-value: 7.00e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181     31 TQAFWKAVTAEFLAMLIFVLLSLGSTINWGG-TEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 109
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKlVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    110 ISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 189
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    190 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLY 248
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 36-251 4.18e-73

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 225.21  E-value: 4.18e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   36 KAVTAEFLAMLIFVLLSLGSTINWGGTEKpLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 115
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG-ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181  116 VFYIAAQCLGAIIGAGILYLVTPPSVVGGLGV---------TMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVT 186
Cdd:cd00333  80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGAnnivagifgTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPP 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502181  187 GSIA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGN---WENHWIYWVGPIIGAVLAGGLYEYV 251
Cdd:cd00333 160 GGLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 40-248 4.51e-67

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 209.46  E-value: 4.51e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181     40 AEFLAMLIFVLLSLGSTI---NWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSV 116
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    117 FYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGN-LTAGHGLLVELIITFQLVFTIFASCD-SKRTDVTGSIALAIG 194
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4502181    195 FSVAIGHLFAINYTGASMNPARSFGPAVI--MGNWENHWIYWVGPIIGAVLAGGLY 248
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFagLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 34-252 4.78e-61

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 194.58  E-value: 4.78e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   34 FWKAVTAEFLAMLIFVLLSLGSTINWGGTekPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 113
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVAVLAGT--KGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181  114 KSVFYIAAQCLGAIIGAGILYLV--------TPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDv 185
Cdd:COG0580  80 DVLPYIIAQLLGAFLGAALVYLIygghfdatEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAP- 158

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502181  186 TGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIM------GNWENHWIYWVGPIIGAVLAGGLYEYVF 252
Cdd:COG0580 159 GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 36-252 2.82e-44

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 152.01  E-value: 2.82e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    36 KAVTAEFLAMLIFVLLSLGSTINWGG--TEKPL-PVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 112
Cdd:PLN00166  19 KAYLSEFIATLLFVFAGVGSAIAFAKltSDAALdPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   113 AKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTmvhGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-L 191
Cdd:PLN00166  99 ITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVA---AGLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIApI 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502181   192 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 252
Cdd:PLN00166 176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
PLN00027 PLN00027
aquaporin TIP; Provisional
 36-252 4.37e-43

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 148.78  E-value: 4.37e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    36 KAVTAEFLAMLIFVLLSLGSTINW-----GGTEKPLPVDMVLISLCFGLSIATMVQCfgHISGGHINPAVTVAMVCTRKI 110
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFnkltdNGSTTPAGLVAAALAHAFALFVAVSVGA--NISGGHVNPAVTFGAFIGGNI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   111 SIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTmvhGNLTAGHGLLVELIITFQLVFTIFASC-DSKRTDVtGSI 189
Cdd:PLN00027  99 TLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLS---SGVGVWNAFVFEIVMTFGLVYTVYATAvDPKKGDL-GII 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4502181   190 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 252
Cdd:PLN00027 175 ApIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIF 238
PRK05420 PRK05420
aquaporin Z; Provisional
 36-252 7.36e-38

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 134.32  E-value: 7.36e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    36 KAVTAEFLAMLIFVLLSLGSTINWGGTeKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 115
Cdd:PRK05420   3 KKLAAEFFGTFWLVFGGCGSAVLAAAF-PELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKEL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   116 VFYIAAQCLGAIIGAGILYLVtppsVVGGLGVTMVHGNLTA-GHG------------LLVELIITFQLVFTIFASCDsKR 182
Cdd:PRK05420  82 VPYIIAQVVGGIAAAAVLYLI----ASGKAGFDLAGSGFASnGYGehspggysllaaLVCEVVLTAFFLLVILGATD-KR 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502181   183 TDVtGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNW--ENHWIYWVGPIIGAVLAGGLYEYVF 252
Cdd:PRK05420 157 APA-GFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00167 PLN00167
aquaporin TIP5; Provisional
 21-254 7.38e-36

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 130.02  E-value: 7.38e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    21 NIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTInwgGTEKPLPVD------MVLISLCFGLSIATMVQCFGHISGG 94
Cdd:PLN00167   8 SLSARFQQSVTRNALRSYLAEFISTFFFVFAAVGSAM---SSRKLMPDAasdpssLLIVAIANAFALSSAVYIAANISGG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    95 HINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTppsVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTI 174
Cdd:PLN00167  85 HVNPAVTFGMAVGGHISVPTAMFYWISQMLASVMACLFLKVTT---VGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   175 FASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCP 254
Cdd:PLN00167 162 YAAGDPRRGLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVFP 241
PLN00026 PLN00026
aquaporin NIP; Provisional
 36-257 1.27e-31

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 119.97  E-value: 1.27e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    36 KAVTAEFLAMLIFVLLSLGSTI---NWGGTEKPLPvdmvlISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 112
Cdd:PLN00026  72 RKLGAEFVGTFILIFAATAGPIvnqKYDGAETLIG-----NAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPW 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   113 AKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVhgnlTAGHGLLVELIITFQLVFTIFASCDSKRTdvTGSIA-L 191
Cdd:PLN00026 147 KHVPAYIAAQVSASICASFALKGVFHPFMSGGVTVPSV----STGQAFALEFIITFNLLFVVTAVATDTRA--VGELAgI 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4502181   192 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVE 257
Cdd:PLN00026 221 AVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLREED 286
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 73-251 1.00e-29

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 114.62  E-value: 1.00e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    73 ISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYL---VTPPSVVGGLGVTm 149
Cdd:PLN00182  78 ICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGAQLTGSLLASLTLRLmfnVTPEAFFGTTPTD- 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   150 vhgnlTAGHGLLVELIITFQLVFTIFASCDSKRTdvTGSIA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWE 228
Cdd:PLN00182 157 -----SSGQALVAEIIISFLLMFVISGVATDSRA--VGELAgIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYK 229

                        170       180
                 ....*....|....*....|...
gi 4502181   229 NHWIYWVGPIIGAVLAGGLYEYV 251
Cdd:PLN00182 230 GIWVYIVGPFVGIIAGGFVYNLI 252
PLN00184 PLN00184
aquaporin NIP1; Provisional
 34-251 1.53e-27

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 108.96  E-value: 1.53e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    34 FWKAVTAEFLAMLIFVLLSLGSTINwgGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 113
Cdd:PLN00184  53 FLQKLIAEVLGTYFLVFTGCASVVV--NMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   114 KSVFYIAAQCLGAIIGAGILYLV--TPPSVVGGLGVTMVhGNLTAGHGL---LVELIITFQLVFTIFASCDSKRTdvTGS 188
Cdd:PLN00184 131 QVPAYVISQVIGSTLAAATLRLLfgLDHDVCSGKHDVFI-GSSPVGSDLqafVMEFIVTFYLMFIISGVATDNRA--IGE 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4502181   189 IA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYV 251
Cdd:PLN00184 208 LAgLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTV 271
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 35-257 1.98e-21

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 92.11  E-value: 1.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    35 WKAVTAEFLAMliFVLLSLGSTINwgGTEKPLPVDMVLISLCFGLSIATMVQCF--GHISGGHINPAVTVAMVCTRKISI 112
Cdd:PTZ00016  50 VREYVAEFLGT--FVLLFFGEGVV--ATTHTVGNNGDYLAITIGWGLGVTFGLLvsAGISGGHLNPAVTLGNAVFGKFPW 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   113 AKSVFYIAAQCLGAIIGAGILYLV----------------TPPSVVGGLGVTMVHGNLTagHGLLVELIITFQLVFTIFA 176
Cdd:PTZ00016 126 KKLPGYFVAQLLGAFVGAACVYGLyygffkdhgipelpweTMANGFAGVFATYPREGNF--YAIFSELILTAILLLVILA 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   177 SCDSKRTDVTGSIALAIGFSV-AIGHLFAINyTGASMNPARSFGP----AVIMGN----WENH--WIYWVGPIIGAVLAG 245
Cdd:PTZ00016 204 ITDPNNCPAFNYLPVAVGLLVfVIGISFGGN-TGYALNPARDLGPrlfsAILWGSevftKDNYyfWVPLVAPFVGAVLGM 282

                        250
                 ....*....|..
gi 4502181   246 GLYEYVFCPDVE 257
Cdd:PTZ00016 283 FLYDKFIPPLIE 294
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 78-248 3.43e-21

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 91.07  E-value: 3.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181    78 GLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGIlylvtppsvvgGLGVTMVHGNLTAG 157
Cdd:PLN00183  86 GLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPLYITAQTVGSVLATYV-----------GVSVYGVKADLMTT 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502181   158 HGLL-------VELIITFQLVFtIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENH 230
Cdd:PLN00183 155 KPAQgcssafwVEFIATFIVMF-LAASLTSQPQSLGHLSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDI 233

                        170
                 ....*....|....*...
gi 4502181   231 WIYWVGPIIGAVLAGGLY 248
Cdd:PLN00183 234 WIYITAPTIGAVAGALMF 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH