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Conserved domains on  [gi|16306539|ref|NP_001787|]
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cadherin-8 isoform 1 preproprotein [Homo sapiens]

Protein Classification

cadherin( domain architecture ID 10638918)

cadherin is a glycoprotein involved in Ca2+-mediated cell-cell adhesion

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 732-790 1.35e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 103.00  E-value: 1.35e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 16306539   732 ADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELY 790
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELY 59
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 281-387 5.97e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 5.97e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539 281 YHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGIIRLRKPLDFETKKSYTLKVEAANv 360
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTATD- 76

                        90       100
                ....*....|....*....|....*..
gi 16306539 361 hidprfSGRGPFKDTATVKIVVEDADE 387
Cdd:cd11304  77 ------GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 395-492 1.30e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.30e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539 395 TYLLEVHENAALNSVIGQVTARDPDITS-SPIRFSIDRHTDlERQFNINADDGKITLATPLDRELSVWHNITIIATEIRN 473
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGEnGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 16306539 474 HSQISRVPVAIKVLDVNDN 492
Cdd:cd11304  80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 171-272 3.45e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.45e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539 171 PYHATVPEMSILGTSVTNVTATDADDpvyGNSAKLVYSILEGQP--YFSIEPETAIIKTALPnMDREAKEEYLVVIQAKD 248
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 16306539 249 MGGHSggLSGTTTLTVTLTDVNDN 272
Cdd:cd11304  77 GGGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 87-165 8.30e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.63  E-value: 8.30e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539     87 TDLDPGSK-KIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDwETSKPLEPPSEFIIKVQDINDNAP 165
Cdd:smart00112   3 TDADSGENgKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 499-602 5.45e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 5.45e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539 499 EYEAFLCENGKPGQVIQTVSAMDKDDPKNGHyFLYSLLPEMVNNPnFTIkknEDNSLSILAKhNGFNRQKQEVYLLPIII 578
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGL-FSI---DPSTGEITTA-KPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 16306539 579 SDSGNPPLSSTSTLTIRVCGcSND 602
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLD-VND 97
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 732-790 1.35e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 103.00  E-value: 1.35e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 16306539   732 ADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELY 790
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELY 59
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 281-387 5.97e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 5.97e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539 281 YHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGIIRLRKPLDFETKKSYTLKVEAANv 360
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTATD- 76

                        90       100
                ....*....|....*....|....*..
gi 16306539 361 hidprfSGRGPFKDTATVKIVVEDADE 387
Cdd:cd11304  77 ------GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 395-492 1.30e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.30e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539 395 TYLLEVHENAALNSVIGQVTARDPDITS-SPIRFSIDRHTDlERQFNINADDGKITLATPLDRELSVWHNITIIATEIRN 473
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGEnGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 16306539 474 HSQISRVPVAIKVLDVNDN 492
Cdd:cd11304  80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 171-272 3.45e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.45e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539 171 PYHATVPEMSILGTSVTNVTATDADDpvyGNSAKLVYSILEGQP--YFSIEPETAIIKTALPnMDREAKEEYLVVIQAKD 248
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 16306539 249 MGGHSggLSGTTTLTVTLTDVNDN 272
Cdd:cd11304  77 GGGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 87-165 8.30e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.63  E-value: 8.30e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539     87 TDLDPGSK-KIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDwETSKPLEPPSEFIIKVQDINDNAP 165
Cdd:smart00112   3 TDADSGENgKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 81-163 1.01e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.89  E-value: 1.01e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539  81 LVGRLH-TDLDPGSK-KIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDwETSKPLEPPSEFIIKVQ 158
Cdd:cd11304  15 VVLTVSaTDPDSGENgEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD-GGGPPLSSTATVTITVL 93


                ....*
gi 16306539 159 DINDN 163
Cdd:cd11304  94 DVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 499-602 5.45e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 5.45e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539 499 EYEAFLCENGKPGQVIQTVSAMDKDDPKNGHyFLYSLLPEMVNNPnFTIkknEDNSLSILAKhNGFNRQKQEVYLLPIII 578
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGL-FSI---DPSTGEITTA-KPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 16306539 579 SDSGNPPLSSTSTLTIRVCGcSND 602
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLD-VND 97
Cadherin pfam00028
Cadherin domain;
281-383 1.34e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539   281 YHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGIIRLRKPLDFETKKSYTLKVEAANV 360
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 16306539   361 HIDPRFSgrgpfkdTATVKIVVE 383
Cdd:pfam00028  77 GGPPLSS-------TATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 414-494 7.52e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 7.52e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539    414 TARDPDI-TSSPIRFSIDRHTDlERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDN 492
Cdd:smart00112   1 SATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 16306539    493 AP 494
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 299-389 1.14e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 1.14e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539    299 KANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGIIRLRKPLDFETKKSYTLKVEAANvhidprfSGRGPFKDTATV 378
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPE----TGEITTTKPLDREEQPEYTLTVEATD-------GGGPPLSSTATV 69

                           90
                   ....*....|..
gi 16306539    379 KIVVEDA-DEPP 389
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
172-253 3.64e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 3.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539   172 YHATVPEMSILGTSVTNVTATDADDpvyGNSAKLVYSILEGQPY--FSIEPETAIIKTALPnMDREAKEEYLVVIQAKDM 249
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76


                  ....
gi 16306539   250 GGHS 253
Cdd:pfam00028  77 GGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 190-274 2.51e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.51e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539    190 TATDADDpvyGNSAKLVYSILEG--QPYFSIEPETAIIKTALPnMDREAKEEYLVVIQAKDMGGHSggLSGTTTLTVTLT 267
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPP--LSSTATVTITVL 74


                   ....*..
gi 16306539    268 DVNDNPP 274
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
396-487 4.67e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 4.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539   396 YLLEVHENAALNSVIGQVTARDPDITS-SPIRFSIDRHtDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNH 474
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPnGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 16306539   475 SQISRVPVAIKVL 487
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
500-597 4.95e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 4.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539   500 YEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFlYSLLPEMVNNpNFTIkkNEDNSLSILAKHngFNRQKQEVYLLPIIIS 579
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGG-NFRI--DPDTGDISTTKP--LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 16306539   580 DSGNPPLSSTSTLTIRVC 597
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
75-158 2.88e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 2.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539    75 SGPEPILVGRLHTDLDPGSKkIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDwETSKPLEPPSEFI 154
Cdd:pfam00028  11 VGTEVLTVTATDPDLGPNGR-IFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGPPLSSTATVT 88


                  ....
gi 16306539   155 IKVQ 158
Cdd:pfam00028  89 ITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 518-602 5.81e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.29  E-value: 5.81e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539    518 SAMDKDDPKNGHYFlYSLLPEMVNNPnFTIkkNEDNSLSILAKHngFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVC 597
Cdd:smart00112   1 SATDADSGENGKVT-YSILSGNDDGL-FSI--DPETGEITTTKP--LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*
gi 16306539    598 GCsND 602
Cdd:smart00112  75 DV-ND 78
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 732-790 1.35e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 103.00  E-value: 1.35e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 16306539   732 ADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELY 790
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELY 59
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 281-387 5.97e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 5.97e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539 281 YHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGIIRLRKPLDFETKKSYTLKVEAANv 360
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTATD- 76

                        90       100
                ....*....|....*....|....*..
gi 16306539 361 hidprfSGRGPFKDTATVKIVVEDADE 387
Cdd:cd11304  77 ------GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 395-492 1.30e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.30e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539 395 TYLLEVHENAALNSVIGQVTARDPDITS-SPIRFSIDRHTDlERQFNINADDGKITLATPLDRELSVWHNITIIATEIRN 473
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGEnGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 16306539 474 HSQISRVPVAIKVLDVNDN 492
Cdd:cd11304  80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 171-272 3.45e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.45e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539 171 PYHATVPEMSILGTSVTNVTATDADDpvyGNSAKLVYSILEGQP--YFSIEPETAIIKTALPnMDREAKEEYLVVIQAKD 248
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....
gi 16306539 249 MGGHSggLSGTTTLTVTLTDVNDN 272
Cdd:cd11304  77 GGGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 87-165 8.30e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.63  E-value: 8.30e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539     87 TDLDPGSK-KIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDwETSKPLEPPSEFIIKVQDINDNAP 165
Cdd:smart00112   3 TDADSGENgKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 81-163 1.01e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.89  E-value: 1.01e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539  81 LVGRLH-TDLDPGSK-KIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDwETSKPLEPPSEFIIKVQ 158
Cdd:cd11304  15 VVLTVSaTDPDSGENgEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD-GGGPPLSSTATVTITVL 93


                ....*
gi 16306539 159 DINDN 163
Cdd:cd11304  94 DVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 499-602 5.45e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 5.45e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539 499 EYEAFLCENGKPGQVIQTVSAMDKDDPKNGHyFLYSLLPEMVNNPnFTIkknEDNSLSILAKhNGFNRQKQEVYLLPIII 578
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGL-FSI---DPSTGEITTA-KPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 16306539 579 SDSGNPPLSSTSTLTIRVCGcSND 602
Cdd:cd11304  75 TDGGGPPLSSTATVTITVLD-VND 97
Cadherin pfam00028
Cadherin domain;
281-383 1.34e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539   281 YHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGIIRLRKPLDFETKKSYTLKVEAANV 360
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 16306539   361 HIDPRFSgrgpfkdTATVKIVVE 383
Cdd:pfam00028  77 GGPPLSS-------TATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 414-494 7.52e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 7.52e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539    414 TARDPDI-TSSPIRFSIDRHTDlERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDN 492
Cdd:smart00112   1 SATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 16306539    493 AP 494
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 299-389 1.14e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.38  E-value: 1.14e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539    299 KANDQDIGENAQSSYDIIDGDGTALFEITSDaqaqDGIIRLRKPLDFETKKSYTLKVEAANvhidprfSGRGPFKDTATV 378
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPE----TGEITTTKPLDREEQPEYTLTVEATD-------GGGPPLSSTATV 69

                           90
                   ....*....|..
gi 16306539    379 KIVVEDA-DEPP 389
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
172-253 3.64e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.56  E-value: 3.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539   172 YHATVPEMSILGTSVTNVTATDADDpvyGNSAKLVYSILEGQPY--FSIEPETAIIKTALPnMDREAKEEYLVVIQAKDM 249
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76


                  ....
gi 16306539   250 GGHS 253
Cdd:pfam00028  77 GGPP 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 190-274 2.51e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.51e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539    190 TATDADDpvyGNSAKLVYSILEG--QPYFSIEPETAIIKTALPnMDREAKEEYLVVIQAKDMGGHSggLSGTTTLTVTLT 267
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPP--LSSTATVTITVL 74


                   ....*..
gi 16306539    268 DVNDNPP 274
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
396-487 4.67e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 4.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539   396 YLLEVHENAALNSVIGQVTARDPDITS-SPIRFSIDRHtDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNH 474
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPnGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 16306539   475 SQISRVPVAIKVL 487
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
500-597 4.95e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 4.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539   500 YEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFlYSLLPEMVNNpNFTIkkNEDNSLSILAKHngFNRQKQEVYLLPIIIS 579
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGG-NFRI--DPDTGDISTTKP--LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 16306539   580 DSGNPPLSSTSTLTIRVC 597
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
75-158 2.88e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 2.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539    75 SGPEPILVGRLHTDLDPGSKkIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDwETSKPLEPPSEFI 154
Cdd:pfam00028  11 VGTEVLTVTATDPDLGPNGR-IFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGPPLSSTATVT 88


                  ....
gi 16306539   155 IKVQ 158
Cdd:pfam00028  89 ITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 518-602 5.81e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.29  E-value: 5.81e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539    518 SAMDKDDPKNGHYFlYSLLPEMVNNPnFTIkkNEDNSLSILAKHngFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVC 597
Cdd:smart00112   1 SATDADSGENGKVT-YSILSGNDDGL-FSI--DPETGEITTTKP--LDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*
gi 16306539    598 GCsND 602
Cdd:smart00112  75 DV-ND 78
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 70-163 1.88e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 49.65  E-value: 1.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16306539  70 VLEEFSGPEpiLVGRLHTDLDPGSKKIKYILS--GDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPl 147
Cdd:cd00031   6 AVEGRSRGS--FRVSIPTDLIASSGEIIKISAagKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP- 82

                        90
                ....*....|....*.
gi 16306539 148 EPPSEFIIKVQDINDN 163
Cdd:cd00031  83 QTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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