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Conserved domains on  [gi|4502637|ref|NP_001828|]
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C-C chemokine receptor type 3 isoform 1 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
35-312 6.70e-155

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15185:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 278  Bit Score: 436.18  E-value: 6.70e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   35 QFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15185   1 QFLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd15185  81 LGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTEDS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCE 274
Cdd:cd15185 161 WKRFHALRMNIFGLALPLLIMVICYTGIIKTLLRCPSKKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFFETDCE 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4502637  275 RSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15185 241 RSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
 
Name Accession Description Interval E-value
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
35-312 6.70e-155

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 436.18  E-value: 6.70e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   35 QFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15185   1 QFLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd15185  81 LGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTEDS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCE 274
Cdd:cd15185 161 WKRFHALRMNIFGLALPLLIMVICYTGIIKTLLRCPSKKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFFETDCE 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4502637  275 RSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15185 241 RSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
57-301 6.03e-60

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 193.67  E-value: 6.03e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637     57 MILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLA 134
Cdd:pfam00001   7 LVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVYyLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637    135 IVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEEL--FEETLCSALYPEDTVYswRHFHTLRMTIFCLVLPL 212
Cdd:pfam00001  87 IVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpeGNVTVCFIDFPEDLSK--PVSYTLLISVLGFLLPL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637    213 LVMAICYTGIIKTLLRCPSKKK--------YKAIRLIFVIMAVFFIFWTPYNVAILLSSyqsilFGNDCERSKHLDLVML 284
Cdd:pfam00001 165 LVILVCYTLIIRTLRKSASKQKssertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDS-----LALDCELSRLLDKALS 239
                         250
                  ....*....|....*..
gi 4502637    285 VTEVIAYSHCCMNPVIY 301
Cdd:pfam00001 240 VTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
40-313 6.90e-59

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 193.46  E-value: 6.90e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637    40 LYSLVFTVGLLGNVVVVMILIKYRrLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:PHA03087  46 VYSTIFFFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGFYN 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   120 EIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYsWRHFH 199
Cdd:PHA03087 125 SMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTMN-WKLFI 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   200 TLRMTIFCLVLPLLVMAICYTGIIKTLLRC-PSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKH 278
Cdd:PHA03087 204 NFEINIIGMLIPLTILLYCYSKILITLKGInKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKSGCKAVKY 283
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 4502637   279 LDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLR 313
Cdd:PHA03087 284 IQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKK 318
 
Name Accession Description Interval E-value
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
35-312 6.70e-155

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 436.18  E-value: 6.70e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   35 QFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15185   1 QFLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd15185  81 LGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTEDS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCE 274
Cdd:cd15185 161 WKRFHALRMNIFGLALPLLIMVICYTGIIKTLLRCPSKKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFFETDCE 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4502637  275 RSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15185 241 RSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
35-312 7.16e-124

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 357.29  E-value: 7.16e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   35 QFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRgHNWVFGHGMCKLLSGFYH 114
Cdd:cd14984   1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAA-DGWVFGSFLCKLVSALYT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd14984  80 INFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDTATT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIL-FGNDC 273
Cdd:cd14984 160 WKTLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRARNHKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQLLGiISRSC 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4502637  274 ERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd14984 240 ELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
35-312 1.27e-117

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 341.73  E-value: 1.27e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   35 QFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVrGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15184   1 RLLPPLYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYA-ANEWVFGNAMCKLLTGLYH 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd15184  80 IGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGSHYTCSPHFPPSQYQF 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRC-PSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDC 273
Cdd:cd15184 160 WKNFQTLKMNILGLVLPLLVMIICYSGILKTLLRCrNEKKRHKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNC 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4502637  274 ERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15184 240 SSSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFRSYL 278
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
35-312 3.31e-117

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 340.70  E-value: 3.31e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   35 QFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15183   1 TLLPPLYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd15183  81 LGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKSLIR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCE 274
Cdd:cd15183 161 WKRFQALKLNLLGLILPLLVMIICYTGIINILLRRPNEKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTPSCE 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4502637  275 RSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15183 241 QSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRKYL 278
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
36-312 4.71e-78

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 240.86  E-value: 4.71e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHnWVFGHGMCKLLSGFYHT 115
Cdd:cd15187   2 FLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLLDQ-WVFGNAMCKIVSGAYYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVySW 195
Cdd:cd15187  81 GFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPGQGN-SW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCER 275
Cdd:cd15187 160 KVFTNFEVNILGLLIPFSILIFCYHNILRNLRRCHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSLHIIDGCQN 239
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4502637  276 SKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15187 240 SQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKKHL 276
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
36-312 5.79e-75

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 232.80  E-value: 5.79e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHnWVFGHGMCKLLSGFYHT 115
Cdd:cd15186   2 FLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLINE-WGLHNAMCKLTTAFFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFeetlCSALYPEDTVYSW 195
Cdd:cd15186  81 GFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTKMKENE----CLGDYPEVLQEIW 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCER 275
Cdd:cd15186 157 PVLRNVELNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPSCDM 236
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4502637  276 SKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15186 237 KKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFRRYL 273
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
36-312 3.73e-71

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 223.01  E-value: 3.73e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYvRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15182   2 FLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASY-HSSGWIFGEILCKAVTSIFYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEEtlcsALYPEDTVYSW 195
Cdd:cd15182  81 GFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSDED----GSLCEYSSIKW 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRMTIFCLVlPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNdCER 275
Cdd:cd15182 157 KLGYYYQQNLFFLI-PLGIIVYCYVRILQTLMRTRTMRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSLKDLTIPI-CEC 234
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4502637  276 SKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15182 235 SKQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
35-312 2.17e-67

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 213.54  E-value: 2.17e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   35 QFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHyVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15171   1 QLVPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAH-AAWHGGSLGNPTCKVLVALSS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHA-VFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYP----- 188
Cdd:cd15171  80 VGLHSEALFNVLLTVQASRVFFHGrLASSARRVAPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSRPhflpa 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  189 EDTvySWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLrcPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIL 268
Cdd:cd15171 160 EET--FWKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQR--FRERQRDLSKLVFAIMVVFLLMWAPYNIALFLSAFKEHF 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4502637  269 FGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15171 236 SLRDCKSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRRL 279
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
40-312 2.82e-60

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 195.19  E-value: 2.82e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRgHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:cd15178   6 IYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVV-KGWIFGTFMCKLVSLLQEANFYS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  120 EIFFIILLTIDRYLAIVHAVFALRARTVTFGVITsIVTWGLAVLAALPEFIFY--ETEELFEETLCSALYPEDTVYSWRH 197
Cdd:cd15178  85 GILLLACISVDRYLAIVHATRALTQKRHLVKFVC-AGVWLLSLLLSLPALLNRdaFKPPNSGRTVCYENLGNESADKWRV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  198 FHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSS-YQSILFGNDCERS 276
Cdd:cd15178 164 VLRILRHTLGFLLPLVVMLFCYGFTIKTLLQTRSFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTlMRTKLITETCELR 243
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4502637  277 KHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15178 244 NHVDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
57-301 6.03e-60

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 193.67  E-value: 6.03e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637     57 MILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLA 134
Cdd:pfam00001   7 LVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVYyLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637    135 IVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEEL--FEETLCSALYPEDTVYswRHFHTLRMTIFCLVLPL 212
Cdd:pfam00001  87 IVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVpeGNVTVCFIDFPEDLSK--PVSYTLLISVLGFLLPL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637    213 LVMAICYTGIIKTLLRCPSKKK--------YKAIRLIFVIMAVFFIFWTPYNVAILLSSyqsilFGNDCERSKHLDLVML 284
Cdd:pfam00001 165 LVILVCYTLIIRTLRKSASKQKssertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDS-----LALDCELSRLLDKALS 239
                         250
                  ....*....|....*..
gi 4502637    285 VTEVIAYSHCCMNPVIY 301
Cdd:pfam00001 240 VTLWLAYVNSCLNPIIY 256
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
36-311 2.30e-59

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 193.05  E-value: 2.30e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYvRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15172   2 FVPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVY-EAHQWIFGNFSCKLLRGIYAI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAV--FALRARTVTFGVITSIVTWGLAVLAALPEFIFYET--EELFEETLCSALYPEDT 191
Cdd:cd15172  81 NFYSGMLLLACISVDRYIAIVQATksFRLRSRTLAYSKLICAAVWLLAILISLPTFIFSEVydFGLEEQYVCEPKYPKNS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  192 VYSWRHFHTLRMTI-FCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFG 270
Cdd:cd15172 161 TAIMWKLLVLSLQVsLGFFIPLLVMIFCYSFIIKTLLQAQNSQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEAINLGEQQ 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4502637  271 NdCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKY 311
Cdd:cd15172 241 S-CSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFRNY 280
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
36-312 4.08e-59

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 192.27  E-value: 4.08e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIhYVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15174   2 FLPPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWA-TAASSGWVFGTFLCKVVNSMYKI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFA--LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVY 193
Cdd:cd15174  81 NFYSCMLLLTCISVDRYIAIVQATKAhnSKNKRLLYSKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMVYPSNESN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSI-LFGND 272
Cdd:cd15174 161 RFKVAVLALKVTVGFFLPFVVMVICYTLIIHTLLQAKRFQKHKALKVIIAVVTVFVLSQLPYNSILLIKTINAYnITITD 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4502637  273 CERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15174 241 CATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKDL 280
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
40-313 6.90e-59

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 193.46  E-value: 6.90e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637    40 LYSLVFTVGLLGNVVVVMILIKYRrLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:PHA03087  46 VYSTIFFFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGFYN 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   120 EIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYsWRHFH 199
Cdd:PHA03087 125 SMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTMN-WKLFI 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   200 TLRMTIFCLVLPLLVMAICYTGIIKTLLRC-PSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKH 278
Cdd:PHA03087 204 NFEINIIGMLIPLTILLYCYSKILITLKGInKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKSGCKAVKY 283
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 4502637   279 LDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLR 313
Cdd:PHA03087 284 IQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKK 318
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
36-312 8.69e-59

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 191.15  E-value: 8.69e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKY-RRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHnWVFGHGMCKLLSGFYH 114
Cdd:cd15188   2 FLPVFYTLVFLLGLAGNLLLFVVLLLYvPKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVAWH-WVFGSFLCKFVSTLYT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFE-ETLCSALYPEDTVY 193
Cdd:cd15188  81 INFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNgVWVCHADYGGHHTI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 sWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDC 273
Cdd:cd15188 161 -WKLVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRPPGQGRALRFVAALVVVFFVLWFPYNLTLFLHSLQDLHVIGNC 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4502637  274 ERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15188 240 ERSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFRLYL 278
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
36-312 1.34e-56

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 185.74  E-value: 1.34e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRgHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15175   2 FLPAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASAA-KKWVFGEEMCKAVYCLYKM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFA--LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALypEDTVY 193
Cdd:cd15175  81 SFFSGMLLLMCISIDRYFAIVQAASAhrHRSRAVFISKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCSIF--TNNKQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFG-ND 272
Cdd:cd15175 159 TLSVKIQISQMVLGFLVPLVVMSFCYSVIIKTLLQARNFEKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFKGNtTD 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4502637  273 CERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15175 239 CDYSKNLDFALDVTYSLACFRCCLNPFLYAFIGVKFRNDL 278
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
36-312 2.49e-56

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 184.89  E-value: 2.49e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVrGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15180   2 FLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQA-VHGWIFGTGLCKLAGAVFKI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETE--ELFEETLCSALYPEDTVY 193
Cdd:cd15180  81 NFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATkdPRQNKTECVHNFPQSDTY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 sWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLR-CPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILL-SSYQSILFGN 271
Cdd:cd15180 161 -WWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRsSQGFQKQRAIRVIVAVVVVFFLCWTPYNIALLVdTLIDLSVLDR 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4502637  272 DCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15180 240 NCGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
36-311 1.59e-54

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 179.97  E-value: 1.59e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIhYVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15173   2 FLPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWA-YSAAHEWIFGTVMCKITNGLYTI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFAL--RARTVTFGVITSIVTWGLAVLAALPEFIfYETEELFEETLCSALYPEDTVY 193
Cdd:cd15173  81 NLYSSMLILTCITVDRFIVIVQATKAHncHAKKMRWGKVVCTLVWVISLLLSLPQFI-YSEVRNLSSKICSMVYPPDAIE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SwrHFHTLRMTIFCLvLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSyqsilFGNDC 273
Cdd:cd15173 160 V--VVNIIQMTVGFF-LPLLAMIICYSVIIKTLLHAKGFQKHKSLKIIFVVVAVFILTQLPYNIMKLIRT-----LHIEN 231
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4502637  274 ERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKY 311
Cdd:cd15173 232 TDSTNFKYAILITEAIAYLHACLNPILYAFVGVKFRKN 269
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
36-310 1.84e-54

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 180.36  E-value: 1.84e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFwIHYVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15177   2 FQPCVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPF-AAAETLQGWIFGNAMCKLIQGLYAI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFA--LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVY 193
Cdd:cd15177  81 NFYSGFLFLTCISVDRYVVIVRATSAhrLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSCRMIFPEVVSR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSyqSILFG--- 270
Cdd:cd15177 161 TVKGATALTQVVLGFAIPLIVMAVCYAAIGRTLLAARGWERHRALRVIAALVVAFVLFQLPYSVVLLLDT--ADLLAtle 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4502637  271 NDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15177 239 LSCSQSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFRR 278
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
36-312 2.63e-53

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 177.24  E-value: 2.63e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVrGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15176   2 FLPVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADA-VNGWVLGTAMCKITSALYTM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAvfALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSW 195
Cdd:cd15176  81 NFSCGMQFLACISVDRYVAITKA--TSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVFPPSLVTSA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSI-LFGNDCE 274
Cdd:cd15176 159 KATIQILEVLLGFVLPFLVMVFCYSRVARALSRTPNVKKSRALKVLLAVVGVFIVTQLPYNVVKFYRAIDVIyLLITDCS 238
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4502637  275 RSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15176 239 MSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFKSHI 276
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
36-312 8.88e-53

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 175.71  E-value: 8.88e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWI-HYVRGhnWVFGHGMCKLLSGFYH 114
Cdd:cd15181   2 FIPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVvESIAG--WVFGTFLCKLVGAIHK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd15181  80 LNFYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEVETSTNANRTSCSFHQYGIHE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMT--IFCLVLPLLVMAICYTGIIKTLLRCPSK-KKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSI-LFG 270
Cdd:cd15181 160 SNWWLTSRFLyhVVGFFLPLLIMGYCYATIVVTLCQSSRRlQKQKAIRVAILVTLVFCLCWLPYNIVIFLDTLDDLkAVV 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4502637  271 NDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15181 240 KNCKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
36-312 2.62e-51

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 171.88  E-value: 2.62e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWiHYVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15179   2 FLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFW-AVDAAANWYFGNFLCKAVHVIYTV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSW 195
Cdd:cd15179  81 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPEDTFELW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSI-LFGNDCE 274
Cdd:cd15179 161 VVAFRFQHILVGLVLPGLVILTCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDTFMLLeIIKQSCE 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4502637  275 RSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15179 241 MEQTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 278
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
36-312 9.93e-49

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 165.24  E-value: 9.93e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYV-RGHNWVFGHGMCKLLSGFYH 114
Cdd:cd14985   2 VIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTaNQYDWPFGAFLCKVSSYVIS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIF--YETEELFEETLCSALYPEDTv 192
Cdd:cd14985  82 VNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLrsLQAIENLNKTACIMLYPHEA- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 ysWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLR------CPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQS 266
Cdd:cd14985 161 --WHFGLSLELNILGFVLPLLIILTCYFHIARSLRKryertgKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQ 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4502637  267 ILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd14985 239 LGAIRPCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
35-312 4.64e-48

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 163.59  E-value: 4.64e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   35 QFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHY-VRGHNWVFGHGMCKLLSGFY 113
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYyLNGGWWPFGDFLCRLTGLLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  114 HTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFE-ETLCSALYPEDTV 192
Cdd:cd14982  81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENnSTTCFEFLSEWLA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 YSwrHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCP-----SKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSI 267
Cdd:cd14982 161 SA--APIVLIALVVGFLIPLLIILVCYSLIIRALRRRSkqsqkSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVRL 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4502637  268 LFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd14982 239 SFIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
36-312 1.25e-43

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 152.21  E-value: 1.25e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFW-IHYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15191   2 AIPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWaTYYSYGYNWLFGSVMCKICGSLLT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVItSIVTWGLAVLAALPEFIF--YETEELFEETLCSALYPEDTV 192
Cdd:cd15191  82 LNLFASIFFITCMSVDRYLAVVYPLRSQRRRSWQARLV-CLLVWVLACLSSLPTFYFrdTYYIEELGVNACIMAFPNEKY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 YSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCP-----SKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSI 267
Cdd:cd15191 161 AQWSAGLALMKNTLGFLIPLIVIATCYFGIGRHLLKTKgfgknKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDALARM 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4502637  268 LFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15191 241 GVINNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
37-312 2.41e-43

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 151.43  E-value: 2.41e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYV-RGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15192   3 IPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTaMEYHWPFGNFLCKIASALVSF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIF--YETEELFEETLCSALYPEDTVY 193
Cdd:cd15192  83 NLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHrdVFFIENTNITVCAFHYPSQNST 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 sWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYK-----AIRLIFVIMAVFFIFWTPYNVAILLSSYQSIL 268
Cdd:cd15192 163 -LLVGLGLMKNLLGFLIPFLIILTCYTLIGKALKKAYEIQRNKprndeIFKMIMAVVLFFFFCWIPHQIFTFLDVLIQLK 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4502637  269 FGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15192 242 VIQDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
58-303 2.17e-42

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 148.59  E-value: 2.17e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV 136
Cdd:cd00637  22 VILRNRRLRTVTNYFILNLAVADLLVgLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISVDRYLAIV 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTvysWRHFHTLRMTIFCLVLPLLVMA 216
Cdd:cd00637 102 HPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLT---LSKAYTIFLFVLLFLLPLLVII 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  217 ICYTGIIKTLLR---------------CPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFgndcersKHLDL 281
Cdd:cd00637 179 VCYVRIFRKLRRhrrrirssssnssrrRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPS-------PLPRI 251
                       250       260
                ....*....|....*....|..
gi 4502637  282 VMLVTEVIAYSHCCMNPVIYAF 303
Cdd:cd00637 252 LYFLALLLAYLNSAINPIIYAF 273
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
24-318 5.33e-42

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 148.90  E-value: 5.33e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637    24 CEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIkYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHyvRGHN-WVFG 102
Cdd:PHA02834  18 CDFEMVNSDVNYFVIVFYILLFIFGLIGNVLVIAVLI-VKRFMFVVDVYLFNIAMSDLMLVFSFPFIIH--NDLNeWIFG 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   103 HGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVfALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETL 182
Cdd:PHA02834  95 EFMCKLVLGVYFVGFFSNMFFVTLISIDRYILVVNAT-KIKNKSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQ 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   183 CsALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLS 262
Cdd:PHA02834 174 C-IFNDYHENFSWSAFFNFEINIFGIVIPLIILIYCYSKILYTLKNCKNKNKTRSIKIILTVVTFTVVFWVPFNIVLFIN 252
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 4502637   263 SYQSI-LFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHR 318
Cdd:PHA02834 253 SLQSVgLIDIGCYHFKKIVYSIDIAELISFVHCCVNPIIYAFVGKNFKKVFKNMFCR 309
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
33-318 6.83e-42

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 150.93  E-value: 6.83e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637    33 MAQFVPPLYSLVFTVGLLGNVVVVMILIkYRRLRIMTNIYLLNLAISDLLFLVTLPFWIhYVRGHNWVFGHGMCKLLSGF 112
Cdd:PHA02638  97 ISEYIKIFYIIIFILGLFGNAAIIMILF-CKKIKTITDIYIFNLAISDLIFVIDFPFII-YNEFDQWIFGDFMCKVISAS 174
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   113 YHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEetlcSALYPEDTV 192
Cdd:PHA02638 175 YYIGFFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFIFEASNIIF----SAQDSNETI 250
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   193 YSWR----------------HFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYN 256
Cdd:PHA02638 251 SNYQctliedneknnisflgRILQFEINILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKSIIIVSIIIICSLICWIPLN 330
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502637   257 VAILLS------SYQSILFGNDCERSKhLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHR 318
Cdd:PHA02638 331 IVILFAtmysfkGFNSIISEHICGFIK-LGYAMMLAEAISLTHCCINPLIYTLIGENFRMHLLMIFRN 397
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
36-310 2.93e-41

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 145.90  E-value: 2.93e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd14970   2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDAY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFE-ETLCSALYPEDTVYs 194
Cdd:cd14970  82 NMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGgTISCNLQWPDPPDY- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTL----LRCPSKKKYKA------IRLIFVIMAVFFIFWTPYNVaillssY 264
Cdd:cd14970 161 WGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLrssrNLSTSGAREKRrarrkvTRLVLVVVAVFVVCWLPFHV------F 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4502637  265 QSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd14970 235 QIVRLLIDPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENFRK 280
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
36-310 4.23e-37

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 134.89  E-value: 4.23e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFW-IHYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15381   2 FQPIYLWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWaINISNGFNWPFGEFLCKSVNAVIY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPE--FIFYETEELFEETLCSALYPEDtv 192
Cdd:cd15381  82 MNLYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMivFRTVMYFPEYNITACVLDYPSE-- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 ySWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTlLRCPSKKKYKAIR-------LIFVIMAVFFIFWTPYNVAILLSSYQ 265
Cdd:cd15381 160 -GWHVALNILLNVVGFLIPLSIITFCSTQIIQV-LRNNKMQKFKEIQterkatvLVLAVLLMFFICWLPFHIFTFLDTLH 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4502637  266 SILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15381 238 KLGLISGCRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
40-312 2.70e-36

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 133.11  E-value: 2.70e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd14993   6 LYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVsLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGVSVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALP-------EFIFYETEELFEETLCSALYPEDT 191
Cdd:cd14993  86 ASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPllvvyelEEIISSEPGTITIYICTEDWPSPE 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  192 vysWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCP----------------SKKKYKAIRLIFVIMAVFFIFWTPY 255
Cdd:cd14993 166 ---LRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKppgdrgsanstssrriLRSKKKVARMLIVVVVLFALSWLPY 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4502637  256 NVAILLSSYQSIlfgNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd14993 243 YVLSILLDFGPL---SSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
38-310 9.70e-36

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 131.44  E-value: 9.70e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   38 PPLYSLVFTVGLLGNVVVVMILIKYRRLRImTNIYLLNLAISDLLFLVTLPFW-IHYVRGHNWVFGHGMCKLLSGFYHTG 116
Cdd:cd15189   5 PFIFSLCLFGLLGNLFVLLVFLLHRRRLTV-AEIYLGNLAAADLVFVSGLPFWaMNILNQFNWPFGELLCRVVNGVIKVN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  117 LYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEEL--FEETLCSALYPEDtvyS 194
Cdd:cd15189  84 LYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIpdLNITACVLLYPHE---A 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTL------LRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIL 268
Cdd:cd15189 161 WHFAHIVLLNIVGFLLPLLVITFCNYNILQALrtreesTRCEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLFDVG 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4502637  269 FGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15189 241 VLDECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
40-312 1.13e-34

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 128.71  E-value: 1.13e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd15158   6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVvYYVHKGQWLFGDFLCRISSYALYVNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCsaLYPEDTVYSWRHF 198
Cdd:cd15158  86 CSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKC--FEPPQSNQQLTKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  199 HTLRMT--IFCLVLPLLVMAICYTGIIKTLLRCPSKKK------YKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFG 270
Cdd:cd15158 164 LVLNYIslVVGFIIPFLVILICYAMIIRTLLKNTMKARkqqssrKKAIRMIIIVLLAFLVSFMPYHIQRTIHLHFLSRKD 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4502637  271 NDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15158 244 STCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRRL 285
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
36-309 1.70e-34

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 127.89  E-value: 1.70e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVR-GHNWVFGHGMCKLLSGFYH 114
Cdd:cd15160   2 FLPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTAnHHNWTFGPLSCKVVGFFFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGL-AVLAALPEFIFYETEELFEETLCSALYPEDTVY 193
Cdd:cd15160  82 TNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLeLGTHSVFLGHDELFRDEPNHTLCYEKYPMEGWQ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWRHFHTLRMTIFclvLPLLVMAICYTGIIKTLLRCPS---KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFG 270
Cdd:cd15160 162 ASYNYARFLVGFL---IPLSLILFFYRRVLRAVRQSPSlerEEKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELVQN 238
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4502637  271 NDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15160 239 GLCGFEKRVFTAYQISLCLTSLNCVADPILYIFVTEDVR 277
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
35-312 3.75e-34

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 127.23  E-value: 3.75e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   35 QFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFY 113
Cdd:cd15921   1 LFYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLtYYVLNSHWPFGDIACRIILYVL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  114 HTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALyPEDTVY 193
Cdd:cd15921  81 YVNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRCLEL-AHDAVD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWRHFHTLRMTIFClVLPLLVMAICYTGIIKTLLRC--------PSKKkyKAIRLIFVIMAVFFIFWTPYNV--AILLSS 263
Cdd:cd15921 160 KLLLINYVTLPVGF-VVPFMTVIFCYIFIIKNLLKPspalgrtrPSRR--KACALIIISLGIFLVCFLPYHIvrTIHLIT 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4502637  264 YQSILFGNDCERSKHLDLVmlVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15921 237 ERQIKESCGYILRVRKAAV--ITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
36-309 4.27e-34

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 127.05  E-value: 4.27e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIH-YVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15168   2 FLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYyYANGDHWIFGDFMCKLVRFLFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd15168  82 FNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSPEELND 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFhTLRMTIFCLVLPLLVMAICYTGIIKTLLRCP-----SKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILF 269
Cdd:cd15168 162 YVIY-SMVLTGLGFLLPLLIILACYGLIVRALIRKLgegvtSALRRKSIRLVIIVLALFAVCFLPFHVTRTINLAARLLS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4502637  270 G-NDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15168 241 GtASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFR 281
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
69-312 5.89e-34

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 126.26  E-value: 5.89e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   69 TNIYLLNLAISDLLFLVTLPFWIHYV-RGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTV 147
Cdd:cd14974  34 NTVWFLNLALADFLFCLFLPFLIVYIaMGHHWPFGSVLCKLNSFVISLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTV 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  148 TFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPED-TVYSWRHfHTLRMTIFCL--VLPLLVMAICYTGIIK 224
Cdd:cd14974 114 RLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTCVEDyDLRRSRH-KALTVIRFLCgfLLPLLIIAICYSVIAV 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  225 TLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSsyqsilFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFV 304
Cdd:cd14974 193 KLRRKRLAKSSKPLRVLLAVVVAFFLCWLPYHVFALLE------LVAAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFM 266

                ....*...
gi 4502637  305 GERFRKYL 312
Cdd:cd14974 267 GQDFRKRL 274
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
36-311 8.45e-34

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 126.02  E-value: 8.45e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15162   2 FLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYhIHGNNWIFGEALCRLVTVAFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE--TLCSALYPEDTV 192
Cdd:cd15162  82 GNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPALdiTTCHDVLPEQLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 YSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPS----KKKYKAIRLIFVIMAVFFIFWTPYNVaILLSSYQSIL 268
Cdd:cd15162 162 VGDWFYYFLSLAIVGFLIPFILTASCYVATIRTLAALEDenseKKKKRAIKLAATVLAIFIICFAPSNL-LLLAHYSLIS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4502637  269 FGNdcerSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKY 311
Cdd:cd15162 241 SSG----TGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFRDH 279
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
60-310 4.85e-33

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 123.44  E-value: 4.85e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   60 IKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHA 138
Cdd:cd14967  25 YRNRRLRTVTNYFIVSLAVADLLVaLLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCAISLDRYLAITRP 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  139 VFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYswrhfhTLRMTIFCLVLPLLVMAIC 218
Cdd:cd14967 105 LRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKIY------VLVSSVISFFIPLLIMIVL 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  219 YTGIIKTLlrcpsKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHLDLVMLVTEVIAYSHCCMNP 298
Cdd:cd14967 179 YARIFRVA-----RRELKAAKTLAIIVGAFLLCWLPFFIIYLVSAF--------CPPDCVPPILYAVFFWLGYLNSALNP 245
                       250
                ....*....|..
gi 4502637  299 VIYAFVGERFRK 310
Cdd:cd14967 246 IIYALFNRDFRR 257
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
36-309 5.01e-33

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 123.70  E-value: 5.01e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIkYRRLRIMTNIYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15372   2 LVPSLYTLVFLVGLPANGLALWVLA-TQVKRLPSTIFLINLAVADLLLILVLPFKIsYHFLGNNWPFGEGLCRVVTAFFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIF--YETEELFEETLCSALYPEDTV 192
Cdd:cd15372  81 GNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQrqSYPLERLNITLCHDVLPLDEQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 YSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRcpSKKKY-KAIRLIFVIMAVFFIFWTPYNVAILL--SSYQSILF 269
Cdd:cd15372 161 DTYLFYYFACLAVLGFLLPLVVILFCYGSVLHTLLR--SGQRYgHAMKLTVLVLVSFVLCFTPSNLLLLLhySDPTLDDG 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4502637  270 GNdcerskhLDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15372 239 GN-------LYIVYMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
37-310 3.02e-32

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 122.14  E-value: 3.02e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRL--RIMTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKLLSGFY 113
Cdd:cd15098   3 VPVVFGLIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLfCVPFQATIYSLPEWVFGAFMCKFVHYFF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  114 HTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVY 193
Cdd:cd15098  83 TVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTASNQTFCWENWPEK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTL---LRCPSKK----KYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQS 266
Cdd:cd15098 163 QQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLhkkLKNMSKKsersKKKTAQTVLVVVVVFGISWLPHHIIHLWVEFGD 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4502637  267 ILFGNDCErskhldLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15098 243 FPLTQASF------VLRITAHCLAYANSCVNPIIYAFLSENFRK 280
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-310 6.64e-32

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 121.79  E-value: 6.64e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGN-VVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYV-RGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15190  13 IPVIYMLVFVLGLSGNgLVLWTVFRSKRKRRRSADTFIANLALADLTFVVTLPLWAVYTaLGYHWPFGSFLCKLSSYLVF 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLC------SALYP 188
Cdd:cd15190  93 VNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVicdmdySGVVS 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  189 EDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTL-------LRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILL 261
Cdd:cd15190 173 NESEWAWIAGLGLSSTVLGFLLPFLIMLTCYFFIGRTVarhfsklRRKEDKKKRRLLKIIITLVVTFALCWLPFHLVKTL 252
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 4502637  262 SSYQSI-LFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15190 253 YALMYLgILPFSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFRQ 302
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
59-309 7.25e-32

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 121.06  E-value: 7.25e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRImTNIYLLNLAISDLLFLVTLPFWIHYVRG-HNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd15380  26 LLPRRRLTI-AEIYLANLAASDLVFVLGLPFWAENIRNqFNWPFGNFLCRVISGVIKANLFISIFLVVAISQDRYRTLVH 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEEL--FEETLCSALYPEDtvySWRHFHTLRMTIFCLVLPLLVM 215
Cdd:cd15380 105 TMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVpdLNISACILLFPHE---AWHFARRVELNIVGFLLPLAAI 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  216 AICYTGIIKTL--------LRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTE 287
Cdd:cd15380 182 VFFNFHIIASLrerteesrKRCGGLKDTKATRLILTLVLMFLVCWTPYHFFAFLDFLFQVEVIQGCFWEEFIDLGLQLAN 261
                       250       260
                ....*....|....*....|..
gi 4502637  288 VIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15380 262 FFAFANSCLNPVIYVFAGKLFR 283
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
36-313 9.84e-32

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 120.73  E-value: 9.84e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15194   2 FLPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKeVVLGPWRSGSFLCKGSSYIIS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSalypEDTVYS 194
Cdd:cd15194  82 VNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCN----EDAGTP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRC------PSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIL 268
Cdd:cd15194 158 SKVIFSLVSLIVAFFLPLLSILTCYCTIIWKLCHHyqksgkHQKKLRKSIKIVFIVVAAFVFSWMPFNLFKALAIASGLQ 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4502637  269 FGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFvgerFRKYLR 313
Cdd:cd15194 238 VEVTCLPYTLAQLGMEVSAPLAFANSCANPFIYYF----FDRYIR 278
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
37-310 1.53e-31

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 120.06  E-value: 1.53e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTG 116
Cdd:cd15091   3 ITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  117 LYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIF--YETEELFEETLCSALYPEDTVYS 194
Cdd:cd15091  83 MFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLggTKVREDVDSTECSLQFPDDDYSW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTL----LRCPSKKKYKAI----RLIFVIMAVFFIFWTPYNVAILLSSYQS 266
Cdd:cd15091 163 WDTFMKICVFIFAFVIPVLIIIVCYTLMILRLksvrLLSGSREKDRNLrritRLVLVVVAVFVVCWTPIHIFILVEALGS 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4502637  267 IlfgndcERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15091 243 V------SHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKR 280
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
40-310 1.99e-31

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 119.89  E-value: 1.99e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:cd15094   6 LYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  120 EIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPE-DTVYSWRHF 198
Cdd:cd15094  86 SSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDsSAVNGQKAF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  199 hTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKY--------KAIRLIFVIMAVFFIFWTPYnvaiLLSSYQSILFG 270
Cdd:cd15094 166 -TLYTFLLGFAIPLLLISVFYTLVILRLRTVGPKNKSkekrrshrKVTRLVLTVISVYIICWLPY----WAFQVHLIFLP 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4502637  271 NDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15094 241 PGTDMPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFRK 280
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
37-312 3.44e-31

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 119.53  E-value: 3.44e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIM--TNIYLLNLAISDLLFLVTLPFW-IHYVRGHNWVFGHGMCKLLSGFY 113
Cdd:cd14976   3 VSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQQseSNKFVFNLALTDLIFVLTLPFWaVEYALDFVWPFGTAMCKVVRYVT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  114 HTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFE-ETLCSALYPEDTV 192
Cdd:cd14976  83 KLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSVnHTLCLLRFPKNSS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 ----YSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLR---CPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILlssyQ 265
Cdd:cd14976 163 vtrwYNWLGMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRkrgGSKRRKSRVTKSVFIVVLSFFICWLPNQALSL----W 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 4502637  266 SILFG-NDCERSKHLDL----VMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd14976 239 SALIKfDDVPFSDAFFAfqtyAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
40-310 1.82e-30

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 117.02  E-value: 1.82e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFW-IHYVRGhNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd15090   6 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQsVNYLMG-TWPFGNILCKIVISIDYYNMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYsWRHF 198
Cdd:cd15090  85 TSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWY-WENL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  199 HTLRMTIFCLVLPLLVMAICYTGIIKTL--LRCPSKKKYK------AIRLIFVIMAVFFIFWTPYNVAILLSSYQSIlfg 270
Cdd:cd15090 164 LKICVFIFAFIMPVLIITVCYGLMILRLksVRMLSGSKEKdrnlrrITRMVLVVVAVFIVCWTPIHIYVIIKALVTI--- 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4502637  271 ndcERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15090 241 ---PETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 277
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
36-310 2.63e-30

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 116.77  E-value: 2.63e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVR-GHNWVFGHGMCKLLSGFYH 114
Cdd:cd15193   2 YIPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTAlGGQWLFGEGLCKLSSFIIA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIfyeTEELFEETLCSalypEDTVYS 194
Cdd:cd15193  82 VNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLV---YRNLINESVCV----EDSSSR 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPS------KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIL 268
Cdd:cd15193 155 FFQGISLATLFLTFVLPLIVILFCYCSILVRLRRHFHgakrtgRRRRNSLRIVFAIVTAFVLSWLPFNTLKAVRLLLELG 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4502637  269 FGN-DCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15193 235 GGVlPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
40-310 3.46e-30

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 116.55  E-value: 3.46e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd15203   6 LYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLcLVSLPFTLIYTLTKNWPFGSILCKLVPSLQGVSIF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVfaLRARTVTFGVITSIVTWGLAVLAALPEFI------FYETEELFEETLCSALYPEDtv 192
Cdd:cd15203  86 VSTLTLTAIAIDRYQLIVYPT--RPRMSKRHALLIIALIWILSLLLSLPLAIfqelsdVPIEILPYCGYFCTESWPSS-- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 ySWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKK-----------------KYKAIRLIFVIMAVFFIFWTPY 255
Cdd:cd15203 162 -SSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKrgkrtlssrrrrselrrKRRTNRLLIAMVVVFAVCWLPL 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4502637  256 NVAILLSSYQSILFGNdcerSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15203 241 NLFNLLRDFEPLPQID----GRHFYLIFLICHLIAMSSACVNPLLYGWLNDNFRK 291
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
40-309 4.25e-30

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 116.40  E-value: 4.25e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHN-WVFGHGMCKLLSGFYHTGLY 118
Cdd:cd14987   6 FYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNqWPMGEFTCKITHLIFSINLF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPE--FIFYETEELFEETLCSALYPEDTVYSWR 196
Cdd:cd14987  86 GSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDtyFLKTVTSPSNNETYCRSFYPEESFKEWL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  197 HFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILL---SSYQSILFgnDC 273
Cdd:cd14987 166 IGMELVSIVLGFVIPFPIIAVFYFLLARAISASSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLdilSFLHLIPF--SC 243
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4502637  274 ERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd14987 244 QLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYR 279
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
58-305 6.80e-30

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 115.66  E-value: 6.80e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRlRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd14975  25 ILIKVKQ-RSVTMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMYASVFLITLMSLERFLAVSR 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDtvySWRHFHTLRMTIFCLVLPLLVMAI 217
Cdd:cd14975 104 PFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMCKYRHYSD---GQLVFHLLLETVVGFAVPFTAVVL 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  218 CYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERS--KHLDLVMLVTEVIAYSHCC 295
Cdd:cd14975 181 CYSCLLRRLRRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSELIGGSKMAGTlgKVAEAGRPIAGALAFLSSS 260
                       250
                ....*....|
gi 4502637  296 MNPVIYAFVG 305
Cdd:cd14975 261 INPLLYAFAA 270
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
58-312 6.95e-30

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 115.63  E-value: 6.95e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIH-YVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV 136
Cdd:cd15088  24 VLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHqFAIDGQWYFGEVMCKIITALDANNQFTSTYILTAMSVDRYLAVV 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELF-EETLCSALYPEDTVYSWrhfHTLRMTIFCLVLPLLVM 215
Cdd:cd15088 104 HPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPdGTTFCYVSLPSPDDLYW---FTIYHFILGFAVPLVVI 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  216 AICYTGIIKTLLRC--------PSKKKYKAIRLIFVIMAVFFIFWTPYNVAILL--------SSYQSILFGNDCerskhl 279
Cdd:cd15088 181 TVCYILILHRLARGvapgnqshGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLVnlamnrptLAFEVAYFLSIC------ 254
                       250       260       270
                ....*....|....*....|....*....|...
gi 4502637  280 dlvmlvtevIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15088 255 ---------LGYANSCLNPFVYILVSENFRKRL 278
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
36-310 8.70e-30

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 115.17  E-value: 8.70e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15375   2 YLPVMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYyINGESWIFGEFMCKFIRFIFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd15375  82 FNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKNNRTICLDFTSSDNLNT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFhTLRMTIFCLVLPLLVMAICYTGIIKTLLRCP---SKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqSILFGN 271
Cdd:cd15375 162 IWWY-NWILTVLGFLLPLVIVTLCYTRIIYTLAKGPhtgSASKQKARRLIILILLVFYVCFLPFHILRVVRIE-TRLPPV 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4502637  272 DCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15375 240 SCCLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQ 278
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
58-309 1.38e-28

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 112.27  E-value: 1.38e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd15092  24 VILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICH 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYsWRHFHTLRMTIFCLVLPLLVMAI 217
Cdd:cd15092 104 PIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEIPTPQDY-WDPVFGICVFLFSFIIPVLIISV 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  218 CYTGIIKTL--LRCPSKKKYK------AIRLIFVIMAVFFIFWTPYNVAILLssyQSILFGNDCERSKhldLVMLVTEVI 289
Cdd:cd15092 183 CYSLMIRRLrgVRLLSGSKEKdrnlrrITRLVLVVVAVFVGCWTPIQIFVLA---QGLGVQPSSETAV---AILRFCTAL 256
                       250       260
                ....*....|....*....|
gi 4502637  290 AYSHCCMNPVIYAFVGERFR 309
Cdd:cd15092 257 GYVNSSLNPVLYAFLDENFK 276
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
35-308 2.74e-28

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 111.32  E-value: 2.74e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   35 QFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFY 113
Cdd:cd15967   1 QFLPPVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVvYYLKGRKWIFGQVFCKITRFCF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  114 HTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEfiFYETEELFEETLCSALYPEDTVY 193
Cdd:cd15967  81 NLNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPD--LFFSKTNSNGTKCFDTTFNDYLE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWRHFhTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKK---KYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIL-F 269
Cdd:cd15967 159 SYLTY-SLGWTVTGFVIPLLIILGCYGHVVVVLCRNNNVDkglKQRCLKLVIILIVLFSVCYIPYHVFRNLNLLSRILqK 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4502637  270 GNDCER-SKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERF 308
Cdd:cd15967 238 QGSCTQwFRGIYIAHQVSRGLVCLNSALNPLVYLMGSEDI 277
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
37-310 2.91e-28

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 111.40  E-value: 2.91e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTG 116
Cdd:cd15093   3 IPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDGIN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  117 LYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFE-ETLCSALYPEdTVYSW 195
Cdd:cd15093  83 MFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDgSSACNMQWPE-PAAAW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRMTIFCLVLPLLVMAICYTGIIKTL----LRCPSKKK----YKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSI 267
Cdd:cd15093 162 SAGFIIYTFVLGFLLPLLIICLCYLLIVIKVksagLRAGWQQRkrseRKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQL 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4502637  268 LFGNDCERSKHLDLVMlvteviAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15093 242 PETPALVGVYHFVVIL------SYANSCANPILYGFLSDNFKK 278
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
40-309 4.75e-28

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 110.67  E-value: 4.75e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd15202   6 AYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMItLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVH 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHavfALRAR-TVTFGVITSIVTWGLAVLAALPEFIFYETEELFEET-----LCSALYPEDTV 192
Cdd:cd15202  86 VSAYTLTAIAVDRYQAIMH---PLKPRiSKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEdivrsLCLEDWPERAD 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 YSWRHFHtLRMTIFCLVLPLLVMAICYTGIIKTLLRCPS-------------KKKYKAIRLIFVIMAVFFIFWTPYNVai 259
Cdd:cd15202 163 LFWKYYD-LALFILQYFLPLLVISFAYARVGIKLWASNMpgdatteryfalrRKKKKVIKMLMVVVVLFALCWLPFNI-- 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 4502637  260 llssYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15202 240 ----YVLLLSSKPDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFR 285
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
41-310 5.71e-28

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 110.79  E-value: 5.71e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   41 YSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWI--HYVRGhnWVFGHGMCKLLSGFYHTGL 117
Cdd:cd15207   7 YSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVgVFCMPFTLvdNILTG--WPFGDVMCKLSPLVQGVSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  118 YSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIvtWGLAVLAALPEFIF-----YETEELFEETLCSALYPEDtv 192
Cdd:cd15207  85 AASVFTLVAIAVDRYRAVVHPTEPKLTNRQAFVIIVAI--WVLALAIMIPQALVlevkeYQFFRGQTVHICVEFWPSD-- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 ySWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCP---------------SKKKYKAIRLIFVIMAVFFIFWTPYNV 257
Cdd:cd15207 161 -EYRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPvpgggsasreaqaavSKKKVRVIKMLIVVVVLFALSWLPLHT 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4502637  258 AILLSSYQSIlfgNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15207 240 VTMLDDFGNL---SPNQREVLYVYIYPIAHWLAYFNSCVNPIVYGYFNRNFRK 289
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
41-312 6.68e-28

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 110.18  E-value: 6.68e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   41 YSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:cd15161   7 YILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYhLSGNHWPFGEVPCRLAGFLFYLNMYA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  120 EIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTvyswrHFH 199
Cdd:cd15161  87 SLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQLYREKA-----SRG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  200 TLRMTIFCLVLPLLVMAICYTGII---KTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERS 276
Cdd:cd15161 162 ALVSLAVAFTIPFVTTVTCYLLIIrslRTGKREEKPLKDKAIKMIILVLTIFLICFVPYHISRYIYILSHNGAGASCSSR 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4502637  277 KHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15161 242 RGLALANRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
36-309 6.97e-28

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 110.27  E-value: 6.97e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15366   2 FPPTLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYfLHRDNWIHGPESCKLFGFIFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLA-ALPEFIFYETEELFEETLCSALYPedtVY 193
Cdd:cd15366  82 TNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGAnSAPLFHDELFRDRYNHTFCFEKYP---ME 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTL---LRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFG 270
Cdd:cd15366 159 DWVAWMNLYRVFVGFLFPWVLMLFSYRGILRAVrgnVSTEQQEKAKIKRLALSLIAIVLLCFAPYHVLLLSRSVVYLGKP 238
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4502637  271 NDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15366 239 CDCGFEERVFTAYHVSLALTSLNCVADPILYCLVNEGAR 277
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
64-310 1.35e-27

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 109.31  E-value: 1.35e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   64 RLRIMTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFAL 142
Cdd:cd15096  30 QMRSTTNILILNLAVADLLFVVfCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSLDRYLAVVHPITSM 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  143 RARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEEtlcSALYpEDTVYSWRHFHTLRMT-----IFCLVLPLLVMAI 217
Cdd:cd15096 110 SIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFS---SEAY-SYCTFLTEVGTAAQTFftsffLFSYLIPLTLICV 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  218 CYTGIIKTLLRCPS----------KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIlfgndcERSKHLDLVMLVTE 287
Cdd:cd15096 186 LYMLMLRRLRRQKSpggrrsaesqRGKRRVTRLVVVVVVVFAICWLPIHIILLLKYYGVL------PETVLYVVIQILSN 259
                       250       260
                ....*....|....*....|...
gi 4502637  288 VIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15096 260 CLAYGNSCVNPILYAFLSQNFRK 282
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
37-310 1.87e-27

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 109.09  E-value: 1.87e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLV-TLPFW--IHYVRGhnWVFGHGMCKLLSGFY 113
Cdd:cd14971   3 VPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLfCVPFTatIYPLPG--WVFGDFMCKFVHYFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  114 HTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFE--ETLCSALYPEdt 191
Cdd:cd14971  81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPgnRTVCSEAWPS-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  192 vYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCP---------SKKKYKAIRLIFVIMAVFFIFWTPYNVAILLS 262
Cdd:cd14971 159 -RAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAvrpvlsegsRRAKRKVTRLVLVVVVLFAACWGPIHAILLLV 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4502637  263 SYqsilfgNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd14971 238 AL------GPFPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRK 279
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
58-312 2.16e-27

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 108.92  E-value: 2.16e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLL--FLVTLPFWIHYVRGhNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd15390  24 IVLAHKRMRTVTNYFLVNLAVADLLisAFNTVFNFTYLLYN-DWPFGLFYCKFSNFVAITTVAASVFTLMAISIDRYIAI 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHAVFALRARTVTFGVITSIvtWGLAVLAALPEFIFYETEELFEET-----LCSALYPEDTVYSWRHFHTLRMTIFCLVL 210
Cdd:cd15390 103 VHPLRPRLSRRTTKIAIAVI--WLASFLLALPQLLYSTTETYYYYTgsertVCFIAWPDGPNSLQDFVYNIVLFVVTYFL 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  211 PLLVMAICYTGIIKTLLRCPS------------KKKYKAIRLIFVIMAVFFIFWTPYNVA-ILLSSYQSILfgndceRSK 277
Cdd:cd15390 181 PLIIMAVAYTRVGVELWGSKTigentprqlesvRAKRKVVKMMIVVVVIFAICWLPYHLYfILTYLYPDIN------SWK 254
                       250       260       270
                ....*....|....*....|....*....|....*
gi 4502637  278 HLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15390 255 YIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
40-306 2.17e-27

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 109.17  E-value: 2.17e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:cd15156   6 VFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  120 EIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPE--FIFYETEELFEETLCSALYPEDTVYSWRH 197
Cdd:cd15156  86 SILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPAsfFQSTNNQLNNNSETCFENFSSKTWKTYLS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  198 FHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSK-----KKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGND 272
Cdd:cd15156 166 KIVIFIEIVGFFIPLILNVTCSTMVLKTLRRPNTLsrsklNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVRTQTFKN 245
                       250       260       270
                ....*....|....*....|....*....|....
gi 4502637  273 CERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGE 306
Cdd:cd15156 246 CSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSE 279
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
39-310 2.20e-27

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 108.63  E-value: 2.20e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   39 PLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGL 117
Cdd:cd15206   5 PLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLaVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  118 YSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELF--EETLCSALYPEDTVysw 195
Cdd:cd15206  85 SVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSrpGGHKCREVWPNEIA--- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLrcpsKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSsyqsiLFGNDCER 275
Cdd:cd15206 162 EQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL----EAKKRVIRMLFVIVVEFFICWTPLYVINTWK-----AFDPPSAA 232
                       250       260       270
                ....*....|....*....|....*....|....*
gi 4502637  276 SKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15206 233 RYVSSTTISLIQLLAYISSCVNPITYCFMNKRFRQ 267
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
70-312 3.29e-27

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 108.26  E-value: 3.29e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   70 NIYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVT 148
Cdd:cd15157  36 NIFMLNLAVSDLMFVSTLPFRAdYYLMGSHWVFGDIACRIMSYSLYVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIK 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  149 FGVITSIVTWGLaVLAALPEFIFYETEELFEETLCSALYPEDTVyswrhfHTLRMTIFCLV----LPLLVMAICYTGIIK 224
Cdd:cd15157 116 YARILCAVIWIF-VMAASSPLLSKGTSKYNSQTKCLDLHPSKID------KLLILNYIVLVvgfiLPFCTLSICYILIIK 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  225 TLLRC--------PSKKkyKAIRLIFVIMAVFFIFWTPYNvaILLSSYQSILFGNDCERSKHLDLVmlVTEVIAYSHCCM 296
Cdd:cd15157 189 ALLKPrvpqsklrVSHK--KALLTIIITLILFLLCFLPYH--ILRTVHLMQWSEGQCNLRLHKAVV--ITLCLAAANSCL 262
                       250
                ....*....|....*.
gi 4502637  297 NPVIYAFVGERFRKYL 312
Cdd:cd15157 263 DPLLYYFAGENFKERL 278
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
40-310 4.66e-27

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 107.63  E-value: 4.66e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:cd15973   6 IYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDGINMFT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  120 EIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFY-ETEELFEETLCSALYPEDtvySWRHF 198
Cdd:cd15973  86 SVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFAdTATRKGQAVACNLIWPHP---AWSAA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  199 HTLRMTIFCLVLPLLVMAICYTGII--------KTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLssyqSILFG 270
Cdd:cd15973 163 FVIYTFLLGFLLPVLAIGLCYILIIgkmravalKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLL----NLFLP 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4502637  271 NDCERSKHLDLVMlvteviAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15973 239 RLDATVNHASLIL------SYANSCANPILYGFLSDNFRR 272
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
58-312 5.89e-27

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 107.81  E-value: 5.89e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV 136
Cdd:cd15389  24 VIFKNKRMHTATNLFIVNLAVSDILItLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTLTLTAIALDRHRVIL 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HavfALRAR-TVTFGVITSIVTWGLAVLAALP-----EFIFYETEELFEETLCSALYPEDTVYSWRHFhTLRMTIFCLVL 210
Cdd:cd15389 104 H---PLKPRiTPCQGVVVIAIIWIMASCLSLPhaiyqKLVEFEYSNERTRSRCLPSFPEPSDLFWKYL-DLATFILQYVL 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  211 PLLVMAICYTGIIKTL-------------LRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIlfgndcersK 277
Cdd:cd15389 180 PLLIIGVAYTRVAKKLwlrnaigdvtteqYVAQRRKKKKTIKMLMLVVLLFAICWLPLNCYHVLLSSHPI---------R 250
                       250       260       270
                ....*....|....*....|....*....|....*
gi 4502637  278 HLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15389 251 SNSALFFAFHWLAMSSTCYNPFIYCWLNDSFRSEL 285
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
58-311 1.14e-26

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 107.13  E-value: 1.14e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV 136
Cdd:cd14992  24 ALARHKNLRGATNYFIASLAISDLLMaLFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAFDRYFAII 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSAL----YPEDTVYSWRHFHTLRMTIFCLVLPL 212
Cdd:cd14992 104 HPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIfccqIPPVDNKTYEKVYFLLIFVVIFVLPL 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  213 LVMAICYTGIIKTLL--------RCPS-----KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSyqsilFGNDCERSKHL 279
Cdd:cd14992 184 IVMTLAYARISRELWfrkvpgfsIKEVerkrlKCKRRVIKMLVCVVVLFVICWLPFHLFFLLRD-----FFPLIMKEKHT 258
                       250       260       270
                ....*....|....*....|....*....|..
gi 4502637  280 DLVMLVTEVIAYSHCCMNPVIYAFVGERFRKY 311
Cdd:cd14992 259 LQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKN 290
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
36-310 2.18e-26

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 106.15  E-value: 2.18e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15970   2 LISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFE-ETLCSALYPEDTvYS 194
Cdd:cd15970  82 NMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDgSVACNMQMPEPS-QR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTL----LRCPSKKKYKAIR----LIFVIMAVFFIFWTPYNVAILLSSYQs 266
Cdd:cd15970 161 WLAVFVVYTFLMGFLLPVIAICLCYILIIVKMrvvaLKAGWQQRKRSERkitlMVMMVVTVFVICWMPFYVVQLVSVFV- 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4502637  267 ilfgndcerSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15970 240 ---------GQHDATVSQLSVILGYANSCANPILYGFLSDNFKR 274
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
71-312 2.58e-26

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 105.95  E-value: 2.58e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   71 IYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTF 149
Cdd:cd15114  36 VWFLNLAVADLLCCLSLPILAvPIAQDGHWPFGAAACKLLPSLILLNMYASVLLLTAISADRCLLVLRPVWCQNHRRARL 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  150 GVITSIVTWGLAVLAALPEFIFYETEELFeetlcsalYPEDTV----YSWRHFHTLRMTIFCLVL----PLLVMAICYTG 221
Cdd:cd15114 116 AWIACGAAWLLALLLTVPSFIYRRIHQEH--------FPEKTVcvvdYGGSTGVEWAVAIIRFLLgflgPLVVIASCHGV 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  222 IIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVA---ILLSSYQSILFGNdcerskhLDLVMLVTEVIAYSHCCMNP 298
Cdd:cd15114 188 LLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYHVVgliIAASAPNSRLLAN-------ALKADPLTVSLAYINSCLNP 260
                       250
                ....*....|....
gi 4502637  299 VIYAFVGERFRKYL 312
Cdd:cd15114 261 IIYVVAGRGFRKSL 274
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
66-310 2.99e-26

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 105.24  E-value: 2.99e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   66 RIMTNIYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRA 144
Cdd:cd15115  31 RTVNTIWFLNLAVADLLCCLSLPFSIaHLLLNGHWPYGRFLCKLLPSIIVLNMFASVFTLTAISLDRFLLVIKPVWAQNH 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  145 RTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSalypedtvYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIK 224
Cdd:cd15115 111 RSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCG--------YDFLVAITITRAVFGFLLPLLIIAACYSFIAF 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  225 TLLRCP-SKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAF 303
Cdd:cd15115 183 RMQRGRfAKSQSKTFRVIIAVVVAFFVCWAPYHIIGILSLY------GDPPLSKVLMSWDHLSIALAYANSCLNPVLYVF 256

                ....*..
gi 4502637  304 VGERFRK 310
Cdd:cd15115 257 MGKDFKK 263
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
37-310 4.14e-26

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 105.42  E-value: 4.14e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTG 116
Cdd:cd15089   3 ITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  117 LYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFE-ETLCSALYPEDTVYsW 195
Cdd:cd15089  83 MFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDgAVVCMLQFPSPSWY-W 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRMTIFCLVLPLLVMAICYTGIIKTL----LRCPSKKKYKAI----RLIFVIMAVFFIFWTPYNVAILLSSYQSI 267
Cdd:cd15089 162 DTVTKICVFIFAFVVPILVITVCYGLMILRLrsvrLLSGSKEKDRNLrritRMVLVVVAAFIICWTPIHIFVIVWTLVDI 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4502637  268 lfgndCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15089 242 -----DRRNPLVVAALHLCIALGYANSSLNPVLYAFLDENFKR 279
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
40-312 6.26e-26

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 105.00  E-value: 6.26e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:cd15155   6 VYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIYG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  120 EIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFH 199
Cdd:cd15155  86 SMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSIWKTYLSKI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  200 TLRMTIFCLVLPLLVMAICYTGIIKTLLRCPS-----KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCE 274
Cdd:cd15155 166 TIFIEVVGFIIPLLLNLTCSSLVLRTLRKPATlsqigTNKEKVLKMILVHVAIFVVCFVPYNSILFLYALVRSQAIANCG 245
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4502637  275 RSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15155 246 VERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
36-312 9.45e-26

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 104.36  E-value: 9.45e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15159   2 LLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIaYYALGFDWPFGDWLCRLTALLFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd15159  82 INTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMGGRITCMEYPNFEKIKR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 wrhfHTLRMTIFCLV---LPLLVMAICYTGIIKTLLR--------CPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSS 263
Cdd:cd15159 162 ----LPLILLGACVIgfgVPVGIILFCYSQITLKLCRtakenpltEKSGHHKKACNVILLVLLVFVVCFSPYHLNIIQFM 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4502637  264 YQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15159 238 IRKLLYQPSCSELKAFKISLQITVCLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
36-312 1.30e-25

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 104.08  E-value: 1.30e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15369   2 FVPSVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYhFSGNDWLFGEAMCRVVTAAFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIF--YETEELFEETLCSALYPEDTV 192
Cdd:cd15369  82 CNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSeqTIQIPDLGITTCHDVLNEQLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 yswRHFHTLRMTIFCLV---LPLLVMAICYTGIIKTLLRCP----SKKKYKAIRLIFVIMAVFFIFWTPYNVaILLSSYQ 265
Cdd:cd15369 162 ---MGYYVYYFSIFSCLfffVPLIITTVCYVSIIRCLSSSSdvanSSKKTRALFMAVAVFCVFVICFGPTNV-LLLAHYV 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 4502637  266 SILFGNDCERSKHLDLVMLVTEVIAyshCCMNPVIYAFVGERFRKYL 312
Cdd:cd15369 238 RFAYTSTNDASYFAYLLCVCVGSIS---CCLDPLIYYYGSSQCQKQL 281
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
57-312 1.42e-25

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 104.07  E-value: 1.42e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVR-GHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd15116  22 IFITGFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAmDFHWPFGRFMCKLNSFLLFLNMFTSVFLLTVISIDRCISV 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALY----PEDTVYSWRHF--------HTLRM 203
Cdd:cd15116 102 VFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKIICFNnfslSGDNSSPEVNQlrnmrhqvMTITR 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  204 TIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGndcersKHLDLVM 283
Cdd:cd15116 182 FLLGFLIPFTIIICCYAAIVLKLKRNRLAKSSKPFKIIAAVIVTFFLCWAPYHILNLLEMEATRSPA------SVFKIGL 255
                       250       260
                ....*....|....*....|....*....
gi 4502637  284 LVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15116 256 PITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
36-310 1.44e-25

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 103.77  E-value: 1.44e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15971   2 FLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTvYSW 195
Cdd:cd15971  82 NQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWPGES-SAW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRMTIFCLVLPLLVMAICYTGIIKTL----LRCPSKKKYKA----IRLIFVIMAVFFIFWTPYNVAILLSSYQSI 267
Cdd:cd15971 161 YTGFIIYTFILGFFVPLTIICLCYLFIIIKVkssgIRVGSSKRKKSekkvTRMVSIVVAVFVFCWLPFYIFNVSSVSVSI 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4502637  268 LFgndcerSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15971 241 SP------TPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKK 277
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
37-312 2.46e-25

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 103.52  E-value: 2.46e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15095   3 VPLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCcVPFTAALYATPSWVFGDFMCKFVNYMMQV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE---TLCSALYPEDTv 192
Cdd:cd15095  83 TVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYgpqTYCREVWPSKA- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 ysWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSK--------------KKYKAIRLIFVIMAVFFIFWTPYNVA 258
Cdd:cd15095 162 --FQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDgnnqseqlseralrQKRKVTRMVIVVVVLFAICWLPNHVL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4502637  259 ILLssyqsilfgNDCERSKHLDLVMLVTEVIA----YSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15095 240 NLW---------QRFDPNFPETYATYALKIAAlclsYANSAVNPFVYAFMGENFRKYF 288
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
39-312 5.50e-25

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 102.54  E-value: 5.50e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   39 PLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd15154   5 VGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQMNMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEelfeetlcSALYPEDTVYswRHF 198
Cdd:cd15154  85 GSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHSSS--------DCLLHGEKVY--RCF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  199 HTLRMTIFCLVLPLLVMAI-------------CYTGIIKTLLRCPSKK---KYKAIRLIFVIMAVFFIFWTPYNVAILLS 262
Cdd:cd15154 155 ESFSDNDWKGLLPLVVLAEilgfllplaavlyCSCRIFVELCRTQEPQqgrRRKTVRLLLVNLVIFLICFVPYNTTLAVY 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 4502637  263 SY-QSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15154 235 GLlRANLVEDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
36-310 6.04e-25

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 102.16  E-value: 6.04e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15968   2 LLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIyNYAMRDRWLFGDFMCRLVRFLFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd15968  82 FNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCYDLAPPALFPH 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WrHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRC-------PSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSI 267
Cdd:cd15968 162 Y-VPYGMALTVSGFLLPFSIILWCYCLVVRTLCRTlgpaeppAQARRRKSIRTIVTVTLLFALCFLPFHITRTIYLAVRV 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4502637  268 LFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15968 241 TPGVPCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKFGR 283
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
36-312 9.95e-25

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 101.41  E-value: 9.95e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15370   2 FLPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYhINGNNWIYGEALCKVLIGFFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRaRTVTFGVITSIVTWGLAVLAALPEFIF--YETEELFEETLCSALYPEDTV 192
Cdd:cd15370  82 GNMYCSILFMTCLSVQRYWVIVNPMSHSR-KKANIAIGISLAIWLLILLVTIPLYLVkqTVFIPALDITTCHDVLPEQLL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 YSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTL-----LRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVaILLSSYQSI 267
Cdd:cd15370 161 VGDMFNYFLSLAIGVFLFPAFLTAVAYVLMIRALkssinDESIEKKRKRAIKLIVTVLVMYLICFTPSNL-LLVVHYFLL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4502637  268 LFGNdcerSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15370 240 KNQG----QSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFRDHV 280
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
36-301 1.06e-24

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 101.41  E-value: 1.06e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILikYRRLR-IMTNIYLLNLAISDLLFLVTLPFWIHY-VRGHNWVFGHGMCKLLSGFY 113
Cdd:cd15371   2 LIPAVYIIVVVLGVPSNAIILWML--FFRLRsVCTAIFYANLAISDLLFCITLPFKIVYhLNGNNWVFGETMCRIITITF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  114 HTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIF--YETEELFEETLCSALYPE-D 190
Cdd:cd15371  80 YGNMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFILkqTYYLKELNITTCHDVLPEcE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  191 TVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTlLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFG 270
Cdd:cd15371 160 QNSNFQFYYFISMAVFGFLIPLVITIFCYISIIRT-LNAYEHKWFWYVKITALVLIIFTICFAPSNVILIIHHFNYYYFN 238
                       250       260       270
                ....*....|....*....|....*....|.
gi 4502637  271 NDcerskHLDLVMLVTEVIAYSHCCMNPVIY 301
Cdd:cd15371 239 ND-----NLYSIYLIALCLGSLNSCLDPFLY 264
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
37-312 1.39e-24

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 101.42  E-value: 1.39e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHN-WVFGHGMCKLLSGFYHT 115
Cdd:cd15374   3 LPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNhWPFGVVACKIVRFLFYA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSW 195
Cdd:cd15374  83 NLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLCHDTTRPEEFDHY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRMtIFCLVLPLLVMAICYTGIIKTLLR---------CPSKKKyKAIRLIFVIMAVFFIFWTPYNVAILLsSYQS 266
Cdd:cd15374 163 VHYSSAVM-VLLFGIPCLVIVVCYGLMARRLCKprvgssrqqGPSSKK-RSLKTIIMVLTVFAICFVPFHITRTL-YYVA 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4502637  267 ILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15374 240 RLLKADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRRRL 285
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-312 1.90e-24

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 100.81  E-value: 1.90e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHY--VRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLA 134
Cdd:cd15204  24 VLARYKKLRTLTNLLIANLALSDFLVaVFCLPFEMDYyvVRQRSWTHGDVLCAVVNYLRTVSLYVSTNALLVIAIDRYLV 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  135 IVHAVFALRARTVTFGVITsiVTWGLAVLAALPE--FIFYETEELFEETLCSALYPEDTVYSWRHFHtLRMTIFCLVLPL 212
Cdd:cd15204 104 IVHPLKPRMKRRTACVVIA--LVWVVSLLLAIPSavYSKTTPYANQGKIFCGQIWPVDQQAYYKAYY-LFLFVLEFVLPV 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  213 LVMAICYTGIIKTLL--RCPS----------KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFgndcERSKHLD 280
Cdd:cd15204 181 LIMTLCYLRIVRKVWfrRVPGqqteqirrrlRRRRRKVRLLVVILTAFVLCWAPYYGYAIVRDFFPTLL----SKEKLNT 256
                       250       260       270
                ....*....|....*....|....*....|..
gi 4502637  281 LVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15204 257 TIFYIVEALAMSNSMINTVVYVAFNNNIRKYL 288
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
62-312 2.10e-24

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 100.96  E-value: 2.10e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   62 YRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVR-GHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVF 140
Cdd:cd15117  27 FRMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTAlGFHWPFGWFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVW 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  141 ALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALY--PEDTVYSWRHFHTLRMT----------IFCL 208
Cdd:cd15117 107 ARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCYLNFdpWNETAEDPVLWLETVVQrlsaqvitrfVLGF 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  209 VLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERskHLDLVMLVTEV 288
Cdd:cd15117 187 LVPLVIIGGCYGLIAARLWREGWVHSSRPFRVLTAVVAAFFLCWFPFHLVSLLELVVILNQKEDLNP--LLILLLPLSSS 264
                       250       260
                ....*....|....*....|....
gi 4502637  289 IAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15117 265 LACVNSCLNPLLYVFVGRDFRERL 288
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
58-309 8.41e-24

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 99.23  E-value: 8.41e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISD--LLFLVTLPFWIHYVRGHnWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd16003  24 IILAHKRMRTVTNYFLVNLAFSDasMAAFNTLINFIYALHSE-WYFGEAYCRFHNFFPITSVFASIYSMTAIAVDRYMAI 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHAVFALRARTVTFGVITSIvtWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFClvLPLLVM 215
Cdd:cd16003 103 IDPLKPRLSATATKVVIGSI--WILAFLLAFPQCLYSKTKVMPGRTLCFVAWPGGPDQHFTYHIIVIVLVYC--LPLLVM 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  216 AICYTGIIKTLL--RCPS----------KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILfgndcERSKHLDLVM 283
Cdd:cd16003 179 GITYTIVGITLWggEIPGdtsdkyheqlRAKRKVVKMMIIVVLTFAICWLPYHIYFIVTGLYQQL-----NRWKYIQQVY 253
                       250       260
                ....*....|....*....|....*.
gi 4502637  284 LVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd16003 254 LASFWLAMSSTMYNPIIYCCLNKRFR 279
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
37-310 9.57e-24

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 98.72  E-value: 9.57e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTG 116
Cdd:cd15974   3 IPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDGVN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  117 LYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIfyETEELFEETLCSALYPEdTVYSWR 196
Cdd:cd15974  83 QFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVII--FSDVQPDLNTCNISWPE-PVSVWS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  197 HFHTLRMTIFCLVLPLLVMAICYTGIIKTL----LRCPSKKKY----KAIRLIFVIMAVFFIFWTPY------NVAILLS 262
Cdd:cd15974 160 TAFIIYTAVLGFFGPLLVICLCYLLIVIKVkssgLRVGSTKRRkserKVTRMVVIIVVVFVFCWLPFymlnivNLIVILP 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4502637  263 SyQSILFGndcerskhldlVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15974 240 E-EPAFVG-----------VYFFVVVLSYANSCANPILYGFLSDNFKQ 275
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
71-312 1.13e-23

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 99.06  E-value: 1.13e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   71 IYLLNLAISDLLFLVTLPFWIHYVRGH-NWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTF 149
Cdd:cd15147  39 IFMVNLTIADLLFLITLPFWIVYYHNEgNWILPKFLCNVAGCLFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKR 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  150 GVITSIVTWGLAVLAALPEFIF----YETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVlpLLVMAICYTGIIKT 225
Cdd:cd15147 119 GIIISVAIWVIIVASASYFLFMdstnTVKIDSGNFTRCFEGYEKDNSKPVLIIHFIIIGLFFLV--FLLILVCNLVIART 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  226 LLRCPSKK------KYKAIRLIFVIMAVFFIFWTPYNVAIL---LSSYQsILFGNDCERSKHLDLVMLVTEVIAYSHCCM 296
Cdd:cd15147 197 LLSQPVQGqrnagvKRRALWMVCTVLAVFVICFVPHHVVQGpwtLAVLQ-QWRYWDCQFRQALNDAHQITLCLMSTNCVL 275
                       250
                ....*....|....*.
gi 4502637  297 NPVIYAFVGERFRKYL 312
Cdd:cd15147 276 DPVIYCFLTKKFRKHL 291
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
40-309 1.63e-23

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 98.20  E-value: 1.63e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLL---FLVTLPFWIHYVRgHNWVFGHGMCKLLSGFYHTG 116
Cdd:cd15392   6 MYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILmavFCVPFSFIALLIL-QYWPFGEFMCPVVNYLQAVS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  117 LYSEIFFIILLTIDRYLAIvhaVFALRAR-TVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE----TLCSALYPEDT 191
Cdd:cd15392  85 VFVSAFTLVAISIDRYVAI---MWPLRPRmTKRQALLLIAVIWIFALATALPIAITSRLFEDSNAscgqYICTESWPSDT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  192 VyswRHFHTLRMTIFCLVLPLLVMAICYT--GIIKTLLRCP-----------SKKKYKAIRLIFVIMAVFFIFWTPYNVA 258
Cdd:cd15392 162 N---RYIYSLVLMILQYFVPLAVLVFTYTriGIVVWAKRTPgeaennrdqrmAESKRKLVKMMITVVAIFALCWLPLNIL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 4502637  259 ILLSS-YQSILFGndcersKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15392 239 NLVGDhDESIYSW------PYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFR 284
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
60-309 1.91e-23

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 97.73  E-value: 1.91e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   60 IKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHA 138
Cdd:cd15001  25 ARFRRMRSVTNVFLASLATADLLLLVFcVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVLTLTAISIERYYVILHP 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  139 VFALRARTVTFGVITSIVTWGLAVLAALPefIFYETEELFEETLCSALYPEDTVYSWRH----FHTLRMTIFCLVLPLLV 214
Cdd:cd15001 105 MKAKSFCTIGRARKVALLIWILSAILASP--VLFGQGLVRYESENGVTVYHCQKAWPSTlysrLYVVYLAIVIFFIPLIV 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  215 MAICYTgiiktllrcpSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqSILFGNDCERSKHLDLVMlvtEVIAYSHC 294
Cdd:cd15001 183 MTFAYA----------RDTRKQVIKMLISVVVLFAVCWGPLLIDNLLVSF-DVISTLHTQALKYMRIAF---HLLSYANS 248
                       250
                ....*....|....*
gi 4502637  295 CMNPVIYAFVGERFR 309
Cdd:cd15001 249 CINPIIYAFMSKNFR 263
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
58-312 2.96e-23

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 97.66  E-value: 2.96e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKlLSGFYHTGL-YSEIFFIILLTIDRYLAI 135
Cdd:cd14969  24 VFLKKKKLRTPLNLFLLNLALADLLMsVVGYPLSFYSNLSGRWSFGDPGCV-IYGFAVTFLgLVSISTLAALAFERYLVI 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHAVFALRARTvTFGVITSIVTWGLAVLAALPEFI-FYETEELFEETLCSALYPEDTVYSWRhfHTLRMTIFCLVLPLLV 214
Cdd:cd14969 103 VRPLKAFRLSK-RRALILIAFIWLYGLFWALPPLFgWSSYVPEGGGTSCSVDWYSKDPNSLS--YIVSLFVFCFFLPLAI 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  215 MAICYTGIIKTL-------------LRCPSKKKY--KAIRLIFVIMAVFFIFWTPYNVAILLSSYQsilfgndcERSKHL 279
Cdd:cd14969 180 IIFCYYKIYRTLrkmskraarrknsAITKRTKKAekKVAKMVLVMIVAFLIAWTPYAVVSLYVSFG--------GESTIP 251
                       250       260       270
                ....*....|....*....|....*....|...
gi 4502637  280 DLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd14969 252 PLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
68-312 3.99e-23

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 97.12  E-value: 3.99e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   68 MTNIYLLNLAISDLLFLVTLPFWIHYV-RGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRART 146
Cdd:cd15119  33 VNTLWFLNLAIADFVFVLFLPLHITYVaLDFHWPFGVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRYRT 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  147 VTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCS----ALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGI 222
Cdd:cd15119 113 LKSALILCGIVWLSAAAISGPALYFRDTMELSINVTICfnnfHKHDGDLIVMRHTILVWVRFFFGFLFPLLTMVVCYSLL 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  223 IKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSilfgNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYA 302
Cdd:cd15119 193 AIKVKRRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILELSIH----HSSYLHNVLRAGIPLATSLAFINSCLNPILYV 268
                       250
                ....*....|
gi 4502637  303 FVGERFRKYL 312
Cdd:cd15119 269 LIGKKFKAHL 278
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
66-305 7.27e-23

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 96.42  E-value: 7.27e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   66 RIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRAR 145
Cdd:cd15121  32 RSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSMYASIFLITLMSMDRCLAVAKPFLSQKMR 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  146 TVTFGVITSIVTWGLAVLAALP-EFIFYETEELFEETLCSALYPEDtvySWRHFHTLRMTIFCLVLPLLVMAICYTGIIK 224
Cdd:cd15121 112 TKRSVRALLLAIWIVAFLLSLPmPFYRTVLKKNINMKLCIPYHPSV---GHEAFQYLFETITGFLLPFTAIVTCYSTIGR 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  225 TLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCER-SKHLDLVMLVTEVIAYSHCCMNPVIYAF 303
Cdd:cd15121 189 RLRSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQAGNASvLKAAKLARPNVTALAFLSSSVNPVLYAF 268

                ..
gi 4502637  304 VG 305
Cdd:cd15121 269 AG 270
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
69-312 8.22e-23

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 96.36  E-value: 8.22e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   69 TNIYLLNLAISDLLFLVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTV 147
Cdd:cd15373  35 STTYMFNLAISDTLYVLSLPLLVYYyADENDWPFSEALCKIVRFLFYTNLYCSILFLLCISVHRFLGVCYPVRSLRWLKV 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  148 TFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTI-FClvLPLLVMAICYTGIIKTL 226
Cdd:cd15373 115 RYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHDTSSPELFDQFVVYSSVMLVLlFC--VPFVVILVCYALMVRKL 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  227 LRCP------SKKKYKAIRLIFVIMAVFFIFWTPYNVA-ILLSSYQSILFgnDCERSKHLDLVMLVTEVIAYSHCCMNPV 299
Cdd:cd15373 193 LKPSagtstnSRSKKKSVKMIIIVLAVFILCFLPFHVTrTLYYSFRSMDL--SCGTLNAINLAYKVTRPLASANSCLDPI 270
                       250
                ....*....|...
gi 4502637  300 IYAFVGERFRKYL 312
Cdd:cd15373 271 LYFLAGQSFRSNL 283
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
70-312 1.63e-22

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 95.73  E-value: 1.63e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   70 NIYLLNLAISDLLFLVTLPFW-IHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVT 148
Cdd:cd15926  37 NLFVTSLAVTDFQFVLTLPFWaVENALDFTWLFGKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCC 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  149 FGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS--WRHFHTLRMTIFCLVLPLLVMAICYTGII--- 223
Cdd:cd15926 117 SAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFPDNRGNAqfWLGLYHAQKVLLGFLIPLGIISLCYLLLVrfi 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  224 --KTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPyNVAI----LLSSYQSILFGNDCERSKHldLVMLVTEVIAYSHCCMN 297
Cdd:cd15926 197 tdKNITGSSTKRRSKVTKSVTIVVLSFFLCWLP-NQALttwgILIKLNVVHFSYEYFTTQV--YIFPITVCLAHSNSCLN 273
                       250
                ....*....|....*
gi 4502637  298 PVIYAFVGERFRKYL 312
Cdd:cd15926 274 PILYCLMRREFRKAL 288
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
36-312 2.03e-22

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 95.21  E-value: 2.03e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd16001   2 LLPVTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIvNYAMRDRWPFGDFLCKLVRFLFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd16001  82 TNLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVCYDLTSPDNFGN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLrMTIFCLVLPLLVMAICYTGIIKTLLRCPSKK------KYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIL 268
Cdd:cd16001 162 YFPYGMV-LTVTGFLIPFLIILLCYCLMIKSLIRSEEAAgvgkaaRAKSIRTILLVCGLFALCFVPFHITRTIYLFVRVY 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4502637  269 FGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd16001 241 LVQDCPLLQFVSLAYKIWRPLVSFNSCINPLLYFLSGDSNRLRL 284
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
69-310 2.29e-22

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 95.09  E-value: 2.29e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   69 TNIYLLNLAISDLLFLVTLPFWIHYvRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVT 148
Cdd:cd15165  35 STIYMINLALNDLLLLLSLPFKMHS-SKKQWPLGRTLCSFLESLYFVNMYGSILIIVCISVDRYIAIRHPFLAKRLRSPR 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  149 FGVITSIVTWGLAVLAALPefIFYETEELFEETLCSALYPEDTvysWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLR 228
Cdd:cd15165 114 KAAIVCLTIWVFVWAGSIP--IYSFHDKPTNNTRCFHGFSNKT---WSKKVIVVVEEFGFLIPMAVMVFCSVQIIRTLLD 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  229 C-----PSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAF 303
Cdd:cd15165 189 MrrpeqPKVKQNKSVKIVLSNLVVFLVCFTPYHLGIFLQFLVKNDIINDCSTKQSIRLFVQVSMCLANVNCCLDAICYYF 268

                ....*..
gi 4502637  304 VGERFRK 310
Cdd:cd15165 269 ILKEFRE 275
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
36-310 3.77e-22

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 94.42  E-value: 3.77e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15087   2 ALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRA--RTVTFGVITSIVTWGLAVLAALPEFIFYETEEL-FEETLCSALYPEDTV 192
Cdd:cd15087  82 NIFSSIYFLTVMSVDRYLVVLATVRSRRMpyRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYSNeLGRKSCVLSFPSPES 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 YSWR--HFHTLrmtIFCLVLPLLVMAICYTGIIKTL--LRCPS------KKKYKAIRLIFVIMAVFFIFWTPYNVAILLS 262
Cdd:cd15087 162 LWFKasRIYTL---VLGFAIPVSTICILYTMMLYKLrnMRLNSnakaldKAKKKVTLMVLVVLAVCLFCWTPFHLSTVVA 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4502637  263 syqsilFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15087 239 ------LTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRK 280
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
71-306 1.03e-21

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 93.31  E-value: 1.03e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   71 IYLLNLAISDLLFLVTLPFWIHYV-RGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTF 149
Cdd:cd15365  37 VYLFNLSLSDLLYIVILPLWIDYLwNGDNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRT 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  150 GVITSIVTWGLAVLA-ALPEFIFYETEELFEETLCSALYPEDtvyswRHFHTLRMTIFCL--VLPLLVMAICYTGI---I 223
Cdd:cd15365 117 ALSVSVAIWLLEICFnAVILTWEDSFHESSSHTLCYDKFPLE-----DWQARLNLFRICLgyLLPLLIILFCYWKIyqaV 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  224 KTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLssyQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAF 303
Cdd:cd15365 192 RSNQATEDQEKKKIFKLLLLITVTFVICFTPYHVVLLI---RSIVEPCDCRNAKWLYTLYKITVALTSLNCIADPFLYCF 268

                ...
gi 4502637  304 VGE 306
Cdd:cd15365 269 VTE 271
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
37-310 1.15e-21

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 92.97  E-value: 1.15e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYR-RLRIMTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15097   3 VPVVFSLIFLLGTVGNSLVLAVLLRSGqSGHNTTNLFILNLSVADLCFILfCVPFQATIYSLEGWVFGSFLCKAVHFFIY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTvys 194
Cdd:cd15097  83 LTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYANSTVCMPGWEEAR--- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 wRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRC---------PSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQ 265
Cdd:cd15097 160 -RKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAvdpleamseSKRAKRKVTKMIIIVTALFCLCWLPHHVVILCYLYG 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4502637  266 SILFgndcerSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15097 239 DFPF------NQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRK 277
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
64-312 1.40e-21

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 92.95  E-value: 1.40e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   64 RLRIMTNIYLLNLAISDLLFLVTLPFWIH-YVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFAL 142
Cdd:cd15339  29 RKKTVPDIYVCNLAVADLVHIIVMPFLIHqWARGGEWVFGSPLCTIITSLDTCNQFACSAIMTAMSLDRYIALVHPFRLT 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  143 RARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSAL---YPEDTVYswrhfHTLRMTIFCLVLPLLVMAICY 219
Cdd:cd15339 109 SLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLESCAFnltSPDDVLW-----YTLYQTITTFFFPLPLILICY 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  220 TGII----------KTLLRC----PSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSilfgndcERSKHLDLVMLV 285
Cdd:cd15339 184 ILILcytwemyrknKKAGRYntsiPRQRVMRLTKMVLVLVGVFLVSAAPYHVIQLVNLSVS-------QPTLAFYVSYYL 256
                       250       260
                ....*....|....*....|....*..
gi 4502637  286 TEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15339 257 SICLSYASSSINPFLYILLSGNFRKRL 283
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
71-310 1.67e-21

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 92.84  E-value: 1.67e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   71 IYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTF 149
Cdd:cd15376  38 VFSFNLAVSDLLYALSLPLLAaYYYPPKNWRFGEAACKLERFLFTCNLYGSIFFITCISLNRYLGIVHPFFTRSHVRPKH 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  150 GVITSIVTWGLAVLAALPEF-IFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLvLPLLVMAICYTGIIKTLLR 228
Cdd:cd15376 118 AKLVSLAVWLLVAALSAPVLsFSHLEVERHNKTECLGTAVDSRLPTYLPYSLFLAVVGCG-LPFLLTLASYLAIVWAVLR 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  229 CPS---KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVG 305
Cdd:cd15376 197 SPGittLEKRKVAALVAVVVALYAVSFVPYHILRNLNLY-RRLQWLKAAASLRIYFAYQVTKGLVTLNMCIHPLLYMAVA 275

                ....*
gi 4502637  306 ERFRK 310
Cdd:cd15376 276 DSIRL 280
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
68-312 2.09e-21

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 92.53  E-value: 2.09e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   68 MTNIYLLNLAISDLLFLVTLPFWIHYVR-GHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRART 146
Cdd:cd14988  34 LVNLYILNMAIADLGVVLTLPVWMLEVMlDYTWLWGSFLCKFTHYFYFANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQ 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  147 VTFGVITSIVTWGLAVLAALPEfIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTL 226
Cdd:cd14988 114 HRIRRALCAGIWVLSAIIPLPE-VVHMQLLDGVEPMCLFLAPFETYDEWALAVSLLTLIIGFLIPFSIIAVFNVLTARYI 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  227 LRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGE 306
Cdd:cd14988 193 RTAGRPESRRHCLLIYAYILVFVVCWLPYHVTLLLLTLHGSHISLHCNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSK 272

                ....*.
gi 4502637  307 RFRKYL 312
Cdd:cd14988 273 SFRGKL 278
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
36-312 2.11e-21

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 92.67  E-value: 2.11e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15377   2 YLPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIfYYFNKTDWIFGDAMCKLQRFIFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALP-EFIFYETEELFEETLCSALYPEDTVY 193
Cdd:cd15377  82 VNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPiLFYSGTGVRKNKTITCYDTTSDEYLR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWrHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKK--------KYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQ 265
Cdd:cd15377 162 SY-FIYSMCTTVAMFCVPFILILGCYGLIVRALIYKDMKYteennaplRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRA 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4502637  266 SILFGND--CERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15377 241 RLDFQTPamCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
37-312 2.32e-21

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 92.14  E-value: 2.32e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15368   3 LPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYhIQRNHWIFGKPLCNVVTVLFYA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFI--FYETEELFEETLCSALYPEDTVY 193
Cdd:cd15368  83 NMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERtdLTYYVKELNITTCFDVLKWTMLP 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWRHFHTLRMTIFCL--VLPLLVMAICYTGIIKTLLRCPSK----KKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSI 267
Cdd:cd15368 163 NIAAWAAFLFTLFILlfLIPFIITVYCYVLIILKLVQTSERygreQKRRAIYLALIVLLVFITCFAPNNFILLAHMVSRL 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4502637  268 LFGndcersKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15368 243 FYG------KSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
58-310 2.73e-21

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 92.17  E-value: 2.73e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd15972  24 VVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQFTSIFCLTVMSVDRYLAVVH 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPefIFYETEELFEETLCSALYPEDTVySWRHFHTLRMTIFCLVLPLLVMAI 217
Cdd:cd15972 104 PIRSSKWRKPPVAKTVNATVWALSFLVVLP--VVIFSGVPGGMGTCHIAWPEPAQ-VWRAGFIIYTATLGFFCPLLVICL 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  218 CYTGII-------KTLLRCPSKKK---YKAIRLIFVIMAVFFIFWTPYNVAILLSsyqsiLFGNDCERSKHLDLVMLVTe 287
Cdd:cd15972 181 CYLLIVvkvrssgRRVRATSTKRRgseRKVTRMVVIVVAAFVLCWLPFYALNIVN-----LVCPLPEEPSLFGLYFFVV- 254
                       250       260
                ....*....|....*....|...
gi 4502637  288 VIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15972 255 VLSYANSCANPIIYGFLSDNFKQ 277
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
40-309 4.05e-21

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 91.97  E-value: 4.05e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFL-VTLP-----FWIHYVrghnWVFGHGMCKLLSGFY 113
Cdd:cd14997   6 VYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLlVCMPvalveTWAREP----WLLGEFMCKLVPFVE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  114 HTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALP-----EFIFYETEELFEETLCsaLYP 188
Cdd:cd14997  82 LTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPvlfitEFKEEDFNDGTPVAVC--RTP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  189 EDTvySWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKA--------------IRLIFVIMAVFFIFWTP 254
Cdd:cd14997 160 ADT--FWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALESRRAdaanrhtlrsrrqvVYMLITVVVLFFVCLLP 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4502637  255 YNV----AILLSSYQSILFGndceRSKHLDLVMLvTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd14997 238 FRVvtlwIIFAPDEDLQALG----LEGYLNLLVF-CRVMVYLNSALNPILYNLMSTKFR 291
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
70-312 4.61e-21

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 91.70  E-value: 4.61e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   70 NIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTF 149
Cdd:cd15378  36 NIYLFNLSVSDLAFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLLHANLYSSILFLTFISIDRYLLIKYPFREHILQKKRS 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  150 GVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPE-DTVYSWrhFHTLRMTIFCLVLPLLVMAICYTGIIKtLLR 228
Cdd:cd15378 116 AVAISLAIWVLVTLELLPILTFIGPNLKDNVTKCKDYASSgDATNSL--IYSLFLTVTGFLIPLCVMCFFYYKIAL-FLK 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  229 CPSKKKYKAIR----LIFVIMAV--FFIFWTPYNVA--ILLSSYQSILFGNDCErSKHLDLVMLVTEVIAYSHCCMNPVI 300
Cdd:cd15378 193 NRNRQLANATSfekpLTLVILAVviFSVLFTPYHVMrnVRIASRLDSIGVSECT-LIIIKSLYIVTRPIAFLNSVINPVF 271
                       250
                ....*....|..
gi 4502637  301 YAFVGERFRKYL 312
Cdd:cd15378 272 YFLMGDHFREML 283
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
64-310 7.85e-21

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 91.02  E-value: 7.85e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   64 RLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALR 143
Cdd:cd15122  32 RGRSVTCILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQS 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  144 ARTVTFGVITSIVTWGLAVLAALPEFIF--YETEELFEETLCSALYPEDTVyswRHFHTLRMTIFCLVLPLLVMAICYTG 221
Cdd:cd15122 112 LRKKALVRKILLAIWLLALLLALPAFVYrhVWKDEGMNDRICEPCHASRGH---AIFHYTFETLVAFVLPFGVILFSYSV 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  222 IIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLV-TEVIAYSHCCMNPVI 300
Cdd:cd15122 189 ILVRLKGARFRRRARVEKLIAAIVVAFALLWVPYHVVNLLQVVANLAPGEVLEKLGGAAKAARAgATALAFFSSSVNPLL 268
                       250
                ....*....|
gi 4502637  301 YAFVGERFRK 310
Cdd:cd15122 269 YVFAAGDLIK 278
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
40-312 8.50e-21

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 90.58  E-value: 8.50e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLL--FLVTLPFWIHYVrGHNWVFGHGMCKLLSGFYHTGL 117
Cdd:cd15012   5 LYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCvgIFCVLQNLSIYL-IPSWPFGEVLCRMYQFVHSLSY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  118 YSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEEtlcSALYPEDTVYSWRH 197
Cdd:cd15012  84 TASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVT---QDGQEEEICVLDRE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  198 FHTLRMT-----IFCLVLPLLVMAICYTGIIKTLLRCPS-KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGN 271
Cdd:cd15012 161 MFNSKLYdtinfIVWYLIPLLIMTVLYSKISIVLWKSSSiEARRKVVRLLVAVVVSFALCNLPYHARKMWQYWSEPYRCD 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4502637  272 DCERSkhldLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15012 241 SNWNA----LLTPLTFLVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
57-310 9.28e-21

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 90.10  E-value: 9.28e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLA 134
Cdd:cd15053  23 MSVFRERSLQTATNYFIVSLAVADLLVaILVMPFAVYVeVNGGKWYLGPILCDIYIAMDVMCSTASIFNLCAISIDRYIA 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  135 IVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSwrhfhtlrmTIFCLVLPLLV 214
Cdd:cd15053 103 VTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEECRFYNPDFIIYS---------SISSFYIPCIV 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  215 MAICYTGIIKTLlrcpsKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSkhLDLVMLVTeVIAYSHC 294
Cdd:cd15053 174 MLLLYYRIFRAL-----RREKKATKTLAIVLGVFLFCWLPFFTLNILNAICPKLQNQSCHVG--PALFSLTT-WLGYVNS 245
                       250
                ....*....|....*.
gi 4502637  295 CMNPVIYAFVGERFRK 310
Cdd:cd15053 246 FLNPIIYTIFNIEFRK 261
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
59-312 1.64e-20

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 89.84  E-value: 1.64e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRIMTNIYLLNLAISDLLFLVTLPFW-IHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd15120  24 VLGFKMRRTVNTLWFLHLILSNLIFTLILPFMaVHVLMDNHWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLH 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFE-ETLCSALYPEDTVYSWRHFHTLRMTI----------F 206
Cdd:cd15120 104 PVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLDEKgKTICQNNYALSTNWESAEVQASRQWIhvamfvfrflL 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  207 CLVLPLLVMAICYTGI---IKTLLRCPSKKKYKairLIFVIMAVFFIFWTPYNVaillssYQSILFGNDCERSKhLDLVM 283
Cdd:cd15120 184 GFLLPFLIITFCYVRMalkMKERGLARSSKPFK---VMFTAVVSFFVCWLPYHL------HSGLVLTRGRPPSL-TDITL 253
                       250       260
                ....*....|....*....|....*....
gi 4502637  284 LVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15120 254 LLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
60-312 1.92e-20

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 89.50  E-value: 1.92e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   60 IKYRRLRIMTNIYLLNLAISDLLfLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAV 139
Cdd:cd14989  26 LSFREKMTIPDLYFVNLAVADLI-LVADSLIEVFNLNEKYYDIAVLCTFMSLFLQINMYSSIFFLTWMSFDRYIALAKVM 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  140 FALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEdtvYSWrhfhtLRMTIfCLVLPLLVMAICY 219
Cdd:cd14989 105 KSSPLRTMQHARLSCGLIWMASISATLLPFTAVQAQHTGEVHFCFADVRE---IQW-----LEVTL-GFIIPFSIIGLCY 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  220 TGIIKTLLR-----CPSKKKYKAIRLIFVIMAVFFIFWTPYNVAI---LLSSYQSILFGNDCERSKHLDLVMLVTEVIAY 291
Cdd:cd14989 176 SLIVRVLVRaqkhrRLRPRRQKALRMILVVVLVFFICWLPENVFIsiqLLQGTQEPSESYDESFRHNHPLTGHIVNLAAF 255
                       250       260
                ....*....|....*....|.
gi 4502637  292 SHCCMNPVIYAFVGERFRKYL 312
Cdd:cd14989 256 SNSCLNPLIYSFLGETFRDKL 276
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
36-311 2.37e-20

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 89.63  E-value: 2.37e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLL-FLVTLPFW-IHYVRgHNWVFGHGMCKLLSGFY 113
Cdd:cd15927   2 VVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLlLLTCVPFTsTIYTL-DSWPFGEFLCKLSEFLK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  114 HTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVY 193
Cdd:cd15927  81 DTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNQTIQICYPYPQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWRHFHTLRMTIFCL----VLPLLVMAICYTGIIKTLLR----------------CPSKKKYKAIRLIFVImaVFFIFWT 253
Cdd:cd15927 161 ELGPNYPKIMVLLRFlvyyLIPLLIIGVFYVLMARHLIRstrnigsgqnqaaqrqIEARKKVAKTVLAFVV--LFAVCWL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4502637  254 PYNVAILLSSYQSilfgNDCERSKHLDLV-MLVTEVIAYSHCCMNPVIYAFVGERFRKY 311
Cdd:cd15927 239 PRHVFMLWFHFAP----NGLVDYNAFWHVlKIVGFCLSFINSCVNPVALYLLSGSFRRH 293
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
41-309 2.59e-20

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 89.52  E-value: 2.59e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   41 YSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:cd16004   7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMaAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  120 EIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIvtWGLAVLAALPEFIFYETEELFEETLCSALYPEDtvYSWRHFH 199
Cdd:cd16004  87 SIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGI--WLVALALAFPQCFYSTVTMDQGRTKCIVAWPGD--SGGKHQL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  200 TLRMTIFCLV--LPLLVMAICYTGIIKTLLRCPS-------------KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSY 264
Cdd:cd16004 163 TYHLAVIVLIylLPLAVMFVTYSIIGITLWRSAVpghqahgayhrqlQAKKKFVKTMVVVVVTFAICWLPYHLYFILGSF 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4502637  265 QsilfgNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd16004 243 N-----EDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFR 282
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
59-316 3.31e-20

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 89.36  E-value: 3.31e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd14986  25 LRRKRKKRSRVNIFILNLAIADLVVaFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFASTYILVSMSLDRYQAIVK 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITsiVTWGLAVLAALPE-FIFYETEELFEETLCSALYPEDtvySWRHFHTLRMTIFCLVLPLLVMA 216
Cdd:cd14986 105 PMSSLKPRKRARLMIV--VAWVLSFLFSIPQlVIFVERELGDGVHQCWSSFYTP---WQRKVYITWLATYVFVIPLIILS 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  217 ICYTGIIKTL---LRCP-------------------------SKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsil 268
Cdd:cd14986 180 YCYGRILRTIwirSRQKtdrpiaptamscrsvscvssrvsliSRAKIKTIKMTLVIILAFILCWTPYFIVQLLDVY---- 255
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4502637  269 FGNDCERSKhldlVMLVTEVIAYSHCCMNPVIYAFvgerFRKYLRHFF 316
Cdd:cd14986 256 AGMQQLEND----AYVVSETLASLNSALNPLIYGF----FSSHLSFEH 295
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
71-306 7.48e-20

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 87.90  E-value: 7.48e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   71 IYLLNLAISDLLFLVTLPFWIHYVRGH-NWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTF 149
Cdd:cd15367  37 IYLCNLTVADLLYIFSLPFWLQYVLQHdNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKA 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  150 GVITSIVTWGLAVLAALPEFIFYETEE-LFEETLCSALYPedtVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLR 228
Cdd:cd15367 117 ATLVSTVIWLKELMTCVFFFLHGEISKdKENHSVCFEHYP---IKAWEHNINYYRFYAGFLFPIFLLSFSYCRILRAVRK 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  229 CPSKKKYKAIRLIFVIMAVFFIF---WTPYNVAILLSSyqsiLFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVG 305
Cdd:cd15367 194 SHGTQKSQKIQIKRLVLSTVVIFlvcFGPYHILLLVRS----VFERDCNFAEGIFNYYHFSLLLTSFNCVADPVLYCFAS 269

                .
gi 4502637  306 E 306
Cdd:cd15367 270 E 270
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
75-310 1.15e-19

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 87.46  E-value: 1.15e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   75 NLAISDLLFLVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVIT 153
Cdd:cd15922  41 NLALSDAIITPAAPLLIAYfSLGSHWPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKL 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  154 SIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDT-----VYSWrhfhtlRMTIFCLVLPLLVMAICYTGIIKTLLR 228
Cdd:cd15922 121 CLGVWLLLFVQGLPFFFVLKTSVIDGKTKCLSIHQSELsllyfVWNF------VLLILGFLLPFGVSLTCYALLGASIAK 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  229 ---CPSKK---KYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYA 302
Cdd:cd15922 195 mnsNNARGramKAKSLQMIGISLVIFIICFVPLHVTRTVGVVVKLFYPESCTLLHKVEVAYYISWVLTGVNCCLDPLLYC 274

                ....*...
gi 4502637  303 FVGERFRK 310
Cdd:cd15922 275 FASEKFRK 282
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
69-309 1.95e-19

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 86.74  E-value: 1.95e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   69 TNIYLLNLAISDLLFLVTLPFWIHYVRgHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVT 148
Cdd:cd15923  35 TNIYMTNLAVADLLLLISLPFKMHSYR-RESAGLQKLCNFVLSLYYINMYVSIFTITAISVDRYVAIRYPLRARELRSPR 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  149 FGVITSIVTWGLAVLAALPEFIFYETEELFEETlcsalypEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLR 228
Cdd:cd15923 114 KAAVVCAVIWVLVVTISIPYFLLDSSNEKTMCF-------QRTKQTESLKVFLLLEIFGFLLPLIIMTFCSARVIHTLQK 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  229 CPS-----KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFgnDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAF 303
Cdd:cd15923 187 RLDdvgsrSETKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVGKSY--SCDSKLIIHFFLQSAFCLSDMNCCLDAFCYYF 264

                ....*.
gi 4502637  304 VGERFR 309
Cdd:cd15923 265 ATKEFR 270
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
40-310 3.37e-19

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 86.37  E-value: 3.37e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd15205   6 TYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLItFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVV 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFeetlcSALYPEDTVYS---- 194
Cdd:cd15205  86 TSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEVKY-----DFLYEKRHVCClerw 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLV----LPLLVMAICYTGIIKTL-LRCP------------------SKKKYKAIRLIFVIMAVFFIF 251
Cdd:cd15205 161 YSPTQQKIYTTFILVilflLPLTTMLFLYSRIGYELwIKKRvgdasvlqtihgiemskiSRKKKRAVKMMVTVVLLFAVC 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4502637  252 WTPYNVAILLSSYQSILFGNDCERSKhldLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15205 241 WAPFHVVHMMIEYSNLENKYDGVTIK---LIFAIVQLIGFSNSFNNPIVYAFMNENFKK 296
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
58-309 3.48e-19

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 86.64  E-value: 3.48e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLL-FLVTLPF-WIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd14979  24 VIARHKSLRTTTNYYLFSLAVSDLLiLLVGLPVeLYNFWWQYPWAFGDGGCKLYYFLFEACTYATVLTIVALSVERYVAI 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHavfALRARTVTF--GVITSI-VTWGLAVLAALPEFIFYETEELFEET--------LCSAlyPEDTVYSWRHFHTLRMT 204
Cdd:cd14979 104 CH---PLKAKTLVTkrRVKRFIlAIWLVSILCAIPILFLMGIQYLNGPLpgpvpdsaVCTL--VVDRSTFKYVFQVSTFI 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  205 IFClvLPLLVMAICYTGIIKTLLRCPSKKKY-------------------KAIRLIFVIMAVFFIFWTPYNVAILLSSYQ 265
Cdd:cd14979 179 FFV--LPMFVISILYFRIGVKLRSMRNIKKGtraqgtrnvelslsqqarrQVVKMLGAVVIAFFVCWLPFHAQRLMFSYA 256
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4502637  266 SILFGNDCERSKHLDlvmLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd14979 257 SKEDTFLFDFYQYLY---PISGILFYLSSAINPILYNLMSSRFR 297
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
41-312 6.85e-19

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 85.62  E-value: 6.85e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   41 YSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE 120
Cdd:cd15153   7 YIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYAS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  121 IFFIILLTIDRYLAIVHAvFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHT 200
Cdd:cd15153  87 ICFLTCISIQRCFFLLHP-FKARDWKRRYDVGISAAVWIVVGLACLPFPLLRSKSLSNNNRSCFADLGMKKLNFGAAIAM 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  201 LRMT-IFCLVLPLLVMAICyTGIIKTLLRCPSKK------KYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDC 273
Cdd:cd15153 166 MTVAeLFGFVIPLFIIAWC-TWKTENSLRQRNKQqqstseKQKALRMVRMCAAVFFICFAPYHINFLFYLMVSESIITNC 244
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4502637  274 ERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15153 245 EVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQDQL 283
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
35-312 8.94e-19

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 85.19  E-value: 8.94e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   35 QFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFY 113
Cdd:cd14991   1 SILPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIdYYLRGEHWIFGEAWCRVNLFML 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  114 HTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVY 193
Cdd:cd14991  81 SVNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHSFSSYTKPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWRHFHTlrmTIFCL--VLPLLVMAICYTGIIKTLLR----CPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSI 267
Cdd:cd14991 161 LSIRWHN---ALFLLefFLPLGLIVFCSVRIACNLRIrqslGKQARVQRAIRLVFLVVIVFVLCFLPSIIAGLLALVFKN 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4502637  268 LfgNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd14991 238 L--GSCRCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFRNSL 280
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
71-352 1.69e-18

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 86.02  E-value: 1.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637    71 IYLLNLAISDLLFLVTLPFWI----HYVRGHNwvfghGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFAlRART 146
Cdd:PHA03235  71 LYMTNLYLANLLTVFVLPFIMlsnqGLLSGSV-----AGCKFASLLYYASCTVGFATVALIAADRYRVIHQRTRA-RSSA 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   147 VTFGVITSIVTWGLAVLAALPEFIFYETE-------ELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICY 219
Cdd:PHA03235 145 YRSTYKILGLTWFASLICSGPAPVYTTVVahddvdpEAPGYETCVIYFRADQVKTVLSTFKVLLTLVWGIAPVVMMTWFY 224
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   220 TGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPV 299
Cdd:PHA03235 225 TFFYRTLKRASYKKRSRTLTFVCILLLSFLCLQTPFVAIMIFDSYATLIWPSDCEHINLRDAVSTLSRLVPNLHCLLNPI 304
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 4502637   300 IYAFVGERFRKYLRHFFHRHLLMHLGryipFLPSEKLERTSSVSPSTAEPELS 352
Cdd:PHA03235 305 LYAFLGNDFLKRFRQCFRGELFSRRA----FLRSRQKCGATAISTVCALPSKT 353
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
71-312 1.96e-18

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 84.04  E-value: 1.96e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   71 IYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTF 149
Cdd:cd15924  36 IYLKNTVVADLLMILTFPFKIlSDAGLGPWQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSF 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  150 GVITSIVTWGLAVLAALPEFIFY-ETEELFEETLCSALYPEDTVysWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLR 228
Cdd:cd15924 116 AKILSVVVWALMFLLSLPNMILTnQQPREKNVKKCSFLKSELGL--KWHEIVNYICQVIFWIVFLLMIVCYTAITKKVYR 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  229 CPSKK-------KYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIY 301
Cdd:cd15924 194 SYRRVfrssssrRKKSNVKIFIIVAVFFVCFVPYHFARIPYTLSQTRDVFDCTAENILFYVKEATLFLSALNVCLDPIIY 273
                       250
                ....*....|.
gi 4502637  302 AFVGERFRKYL 312
Cdd:cd15924 274 FFLCKSFRESL 284
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
41-310 2.08e-18

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 84.28  E-value: 2.08e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   41 YSLVFTVGLLGNVVVVMILIKYRRLRIM-TNIYLLNLAISDLLF-LVTLPFWIhyvrGHN----WVFGHGMCKLLSGFYH 114
Cdd:cd15382   7 YSVLFLIAAVGNLTVLLILLRNRRRKRSrVNILLMHLAIADLLVtFIMMPLEI----GWAatvaWLAGDFLCRLMLFFRA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRA-RTVTFGVITSivtWGLAVLAALPEFIfyeteelfeeTLCSALYPEDTVY 193
Cdd:cd15382  83 FGLYLSSFVLVCISLDRYFAILKPLRLSDArRRGRIMLAVA---WVISFLCSIPQSF----------IFHVESHPCVTWF 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SW--------RHFHTLRMTIFCL----VLPLLVMAICYTGI-------------------IKTLLRCPS-----KKKYKA 237
Cdd:cd15382 150 SQcvtfnffpSHDHELAYNIFNMitmyALPLIIIVFCYSLIlceisrkskekkedvseksSSVRLRRSSvglleRARSRT 229
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4502637  238 IRLIFVIMAVFFIFWTPYNVAillssyqSILFGNDCERSKHLD-LVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15382 230 LKMTIVIVLVFIICWTPYFIM-------SLWYWFDRESASKVDpRIQKGLFLFAVSNSCMNPIVYGYFSIDLRR 296
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
57-312 5.62e-18

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 83.00  E-value: 5.62e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMT--NIYLLNLAISDLLFLVTLPFW-IHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYL 133
Cdd:cd15925  22 MYLLRNCARRAPPpiDVFVFNLALADFGFALTLPFWaVESALDFHWPFGGAMCKMVLTATVLNVYASVFLLTAMSVTRYW 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  134 AIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDtvySWRHFHTLRMTIFCLVLPLL 213
Cdd:cd15925 102 VVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLKFPSN---YWLGAYHLQRVVVAFVVPLG 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  214 VMAICYTGIIKTLLRCPS-----KKKYKAIRLIFVIMAVFFIFWTPYNVAIL---LSSYQSILFgNDCERSKHlDLVMLV 285
Cdd:cd15925 179 VITTSYLLLLSFLQQHKVnqnnrQRQSVIARSVRLVVASFFLCWFPNHVVTFwgvLVKFRAVPW-NSTFYFIH-TYVFPV 256
                       250       260
                ....*....|....*....|....*..
gi 4502637  286 TEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15925 257 TTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
40-309 6.83e-18

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 82.61  E-value: 6.83e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd15978   6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLcLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALP-----EFIFYETEELFEETLCSALYPED-TV 192
Cdd:cd15978  86 VSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPypiysNLVPFTRINNSTGNMCRLLWPNDvTQ 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 YSWrhfHTLRMTIFCLVlPLLVMAICYTGIIKTLLRCPS--KKKYKAIRLIFVIMAVFFIFWTPynvaiLLSSYQSILFG 270
Cdd:cd15978 166 QSW---YIFLLLILFLI-PGIVMMTAYGLISLELYRGIKflMAKKRVIRMLIVIVILFFLCWTP-----IFSANAWRAFD 236
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4502637  271 NDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15978 237 TRSADRLLSGAPISFIHLLSYTSACVNPIIYCFMNKRFR 275
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
40-312 7.35e-18

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 82.55  E-value: 7.35e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd15979   6 LYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVfCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEEL-----FEETLCSALYPEDTVy 193
Cdd:cd15979  86 VSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVpvgdrPRGHQCRHAWPSAQV- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 swRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKyKAIRLIFVIMAVFFIFWTPYNVAILLSSYQsilfgndc 273
Cdd:cd15979 165 --RQAWYVLLLLILFFIPGVVMIVAYGLISRELYRGLLAKK-RVIRMLVVIVAMFFLCWLPIFSANTWRAFD-------- 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4502637  274 ERSKHLDLV---MLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15979 234 PLSAHRALSgapISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
58-310 8.25e-18

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 82.46  E-value: 8.25e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV 136
Cdd:cd15393  24 VVAKNRRMRTVTNIFIANLAVADIIIgLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSVFTLTVIAVDRYRAVI 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HAVFALRARTVTFGVITSIvtWGLAVLAALPEFIFYETEELFEETL------CSALYPEDTvySWRHFHTLrMTIFCLVL 210
Cdd:cd15393 104 HPLKARCSKKSAKIIILII--WILALLVALPVALALRVEELTDKTNngvkpfCLPVGPSDD--WWKIYNLY-LVCVQYFV 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  211 PLLVMAICYTGIIKTL--LRCP-----------SKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSilfgnDCERSK 277
Cdd:cd15393 179 PLVIICYAYTRIAVKIwgTKAPgnaqdvrddeiLKNKKKVIKMLIIVVALFALCWLPLQTYNLLNEIKP-----EINKYK 253
                       250       260       270
                ....*....|....*....|....*....|...
gi 4502637  278 HLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15393 254 YINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKR 286
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
59-257 1.04e-17

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 81.92  E-value: 1.04e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIH-YVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd15170  26 IRKVRRKPTPIDILLLNLTVSDLIFLLFLPFKMAeAASGMIWPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGVAF 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLC--SALYPEDTVYSWRHFHTLRMTIFCL--VLPLL 213
Cdd:cd15170 106 PIKYKLRRRPLYAVIASVFFWVLAFSHCSIVYIVEYHIDSENTSVTnnSRCYDNFTPEQLKILLPVRLELFLVlfCIPFL 185
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 4502637  214 VMAICYTGIIKTLLRCPS---KKKYKAIRLIFVIMAVFFIFWTPYNV 257
Cdd:cd15170 186 ITCFCYINFIRILSSLPHisrQRKQRAIGLAVATLLNFIVCFAPYNI 232
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
37-257 3.17e-17

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 80.69  E-value: 3.17e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIH-YVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15379   3 LPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYnYTQKDYWPFGDFTCRLVRFQFYT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFAL---RARTVTFGVITSIvtWGLAVLAALPEFIFYETEELFEETLCSALYPEDTV 192
Cdd:cd15379  83 NLHGSILFLTCISVQRYLGICHPLASWhkkKGKKLTWLVCGAV--WLVVIAQCLPTFVFASTGTQRNRTVCYDLSPPARS 160
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4502637  193 YSWRHFhTLRMTIFCLVLPLLVMAICYTGIIKTLLR---------CPSKKKYKAIRLIFVIMAVFFIFWTPYNV 257
Cdd:cd15379 161 TAYFPY-GITLTRTGFLLPFAARLACYCSMATILCRvviavavvaAPGEKRGKAARMIIVVAAVFLISFLPFHY 233
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
58-312 4.75e-17

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 80.45  E-value: 4.75e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKL---LSGFYhtGLYSeIFFIILLTIDRYL 133
Cdd:cd15083  24 AFCRFKSLRTPANYLIINLAISDFLMcILNCPLMVISSFSGRWIFGKTGCDMygfSGGLF--GIMS-INTLAAIAVDRYL 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  134 AIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFI-FYETEELFEETLCSALYPEDTVYSwrHFHTLRMTIFCLVLPL 212
Cdd:cd15083 101 VITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFgWSRYVLEGLLTSCSFDYLSRDDAN--RSYVICLLIFGFVLPL 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  213 LVMAICYTGIIKTLLRC----------------PSKKK-----YKAIRLIFVIMAVFFIFWTPYNVAILLSsyqsiLFGN 271
Cdd:cd15083 179 LIIIYCYSFIFRAVRRHekamkemakrfskselSSPKArrqaeVKTAKIALLLVLLFCLAWTPYAVVALIG-----QFGY 253
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4502637  272 DcerSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15083 254 L---EVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
58-310 4.92e-17

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 80.01  E-value: 4.92e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLFLVTL-PFWIHYVRGHNWVFGHGMCKlLSGFyhTGLYSEIFFIILLT---IDRYL 133
Cdd:cd15074  24 VLYRRRSKLKPAELLTVNLAVSDLGISVFGyPLAIISAFAHRWLFGDIGCV-FYGF--CGFLFGCCSINTLTaisIYRYL 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  134 AIVHAVFALR-ARTVTFGVITSIvtWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHF-HTLRMTIFCLVLP 211
Cdd:cd15074 101 KICHPPYGPKlSRRHVCIVIVAI--WLYALFWAVAPLVGWGSYGPEPFGTSCSIDWTGASASVGGMsYIISIFIFCYLLP 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  212 LLVMAICYTGIIKTL-----------LRCPSKKK--YKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIlfgndcerSKH 278
Cdd:cd15074 179 VLIIVFSYVKIIRKVkssrkrvagfdSRSKRQHKieRKVTKVAVLICAGFLIAWTPYAVVSMWSAFGSP--------DSV 250
                       250       260       270
                ....*....|....*....|....*....|..
gi 4502637  279 LDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15074 251 PILASILPALFAKSSCMYNPIIYLLFSSKFRQ 282
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
39-312 7.65e-17

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 79.78  E-value: 7.65e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   39 PLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHN-WVFGHGMCKLLSGFYHTG 116
Cdd:cd15394   5 PLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATcVPLTLAYAFEPRgWVFGRFMCYFVFLMQPVT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  117 LYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIvtWGLAVLAALPEFIFYETEELFE--ETLCSALYpeDTVYS 194
Cdd:cd15394  85 VYVSVFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAAI--WLLSCGLALPAAAHTYYVEFKGldFSICEEFW--FGQEK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRC-------------PSKKKYKAIRLIFVIMAVFFIFWTPYNVAILL 261
Cdd:cd15394 161 QRLAYACSTLLITYVLPLLAISLSYLRISVKLRNRvvpgsmtqsqaewDRARRRKTFRLLVVVVVAFAICWLPLHIFNVI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 4502637  262 SSYQSilfgnDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15394 241 RDIDI-----DLIDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFRGEL 286
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
71-303 7.91e-17

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 79.32  E-value: 7.91e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   71 IYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTF 149
Cdd:cd15201  37 VYLFNLAVADFLLIICLPFRTdYYLRGKHWKFGDIPCRIVLFMLAMNRAGSIFFLTAVAVDRYFRVVHPHHRINSISVRK 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  150 GVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLrMTIFCLVLPLLVMAICYTGIIKTLLR- 228
Cdd:cd15201 117 AAIIACGLWLLTIAMTVYLLTKKHLFPRGNATQCESFNICTGTDSSSNWHEA-MFLLEFFLPLAIILYCSVRIIWQLRGr 195
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502637  229 --CPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAF 303
Cdd:cd15201 196 qlDRHAKIKRAVQFIMVVAIVFIICFLPSNVTRIAIWILKHTSNEDCQYYRSVDLAFYITISFTYFNSMLDPVVYYF 272
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-315 9.08e-17

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 79.61  E-value: 9.08e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15125   3 IPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYFYEEWMFGTVGCKLIPVIQLT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSAL----YPEDT 191
Cdd:cd15125  83 SVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPDDNTTFTacipYPQTD 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  192 VYSWRhFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCP----------------SKKKYKAIRLIFVimAVFFIFWTPY 255
Cdd:cd15125 163 EMHPK-IHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAhnipgeysehskrqmeTRKRLAKIVLVFV--GLFAFCWFPN 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  256 NVAILLSSYQSilfgNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRkylRHF 315
Cdd:cd15125 240 HVLYMYRSFNY----NEIDSSLGHMIVTLVARVLSFCNSCVNPFALYLLSESFR---RHF 292
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
37-312 9.61e-17

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 79.39  E-value: 9.61e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd14977   3 IMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLcVPLNAYNLLTKDWLFGDVMCKLVPFIQVT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVfalraRTVTFGVITSI-----VTWGLAVLAALPEFIFYETEELFEETLCS----AL 186
Cdd:cd14977  83 SLGVTVFSLCALSIDRYRAAVNSM-----PMQTIGACLSTcvklaVIWVGSVLLAVPEAVLSTVARESSLDNSSltvcIM 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  187 YPE-------DTVYSWRHFhtlrMTIFClvLPLLVMAICYTGIIKTLLRCPS----------KKKYKAIRLIFVIMAVFF 249
Cdd:cd14977 158 KPStpfaetyPKARSWWLF----GCYFC--LPLAFTAVCYLLMARTLIRAAKeytrgtkkhmKQRRQLAKTVLCLVLVFA 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502637  250 IFWTPYNVAILLSSYQSIlfGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd14977 232 FCWLPEHISNILRATLYN--EVLIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
58-310 9.74e-17

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 79.40  E-value: 9.74e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDL-LFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV 136
Cdd:cd15073  24 TFVKFRELRTPTNALIINLAVTDLgVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAVDRYLTIC 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HAVFALRARTVTFGVItSIVTWGLAVLAALPEFIfyeteelfeETLCSALYPEDTV--YSWRH----FHTLRMTIF--CL 208
Cdd:cd15073 104 RPDLGRKMTTNTYTVM-ILLAWTNAFFWAAMPLV---------GWASYALDPTGATctINWRKndssFVSYTMSVIvvNF 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  209 VLPLLVMAICYTGIIKTLLRCPSKKKYKAIR-----------LIFVIMAVFFIFWTPYNVAILLSSYQsilfgndcERSK 277
Cdd:cd15073 174 IVPLAVMFYCYYNVSRFVKKVLASDCLESVNidwtdqndvtkMSVIMIVMFLVAWSPYSIVCLWASFG--------EPKK 245
                       250       260       270
                ....*....|....*....|....*....|...
gi 4502637  278 HLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15073 246 IPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRR 278
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
68-309 1.19e-16

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 78.99  E-value: 1.19e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   68 MTNIYLLNLAISDLLFLV-TLPFW-IHYVRGHnWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVfalRAR 145
Cdd:cd15002  35 LIDSLILNLSAADLLLLLfSVPFRaAAYSKGS-WPLGWFVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPT---KQV 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  146 TVTFGVITSIVT--WGLAVLAALPEFIFYETEELFEETLCSALYPEDT-----VYSWRHFhtlrMTIFClvLPLLVMAIC 218
Cdd:cd15002 111 TIKQRRITAVVAsiWVPACLLPLPQWLFRTVKQSEGVYLCILCIPPLAhefmsAFVKLYP----LFVFC--LPLTFALFY 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  219 YTGIIKTLLRCPSK--------KKYKAIRLIFVIMAVFFIFWTPYNVAILLssyqsiLFGNDCERSKHLDLVMLVTEVIA 290
Cdd:cd15002 185 FWRAYGQCQRRGTKtqnlrnqiRSRKLTHMLLSVVLAFTILWLPEWVAWLW------LIHIKSSGSSPPQLFNVLAQLLA 258
                       250
                ....*....|....*....
gi 4502637  291 YSHCCMNPVIYAFVGERFR 309
Cdd:cd15002 259 FSISSVNPIIFLLMSEEFR 277
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
71-312 1.90e-16

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 78.64  E-value: 1.90e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   71 IYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRaRTVTFG 150
Cdd:cd14999  36 VYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTMHASIFTLTVMSTERYLAVVKPLDTVK-RSKSYR 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  151 VITSIVTWGLAVLAALPEFIFYETEELFEETLCSA--LYPEDTVYSWRHFHTLrMTIFCLVLPLLVMAICYTGIIKTLLR 228
Cdd:cd14999 115 KLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSKriCLPTWSEESYKVYLTL-LFSTSIVIPGLVIGYLYIRLARKYWL 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  229 CPS---------KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDcersKHLDLVMLVTEVIAYSHCCMNPV 299
Cdd:cd14999 194 SQAaasnssrkrLPKQKVLKMIFTIVLVFWACFLPFWIWQLLYLYSPSLSLSP----RTTTYVNYLLTCLTYSNSCINPF 269
                       250
                ....*....|...
gi 4502637  300 IYAFVGERFRKYL 312
Cdd:cd14999 270 LYTLLTKNYKEYL 282
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
60-310 2.03e-16

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 78.50  E-value: 2.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   60 IKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHA 138
Cdd:cd15048  26 IKDKKLRTVSNFFLLNLAVADFLVgLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKA 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  139 VFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFeetlcSALYPEDT-VYSWRHFH-TLRMTIFCLVLPLLVMA 216
Cdd:cd15048 106 VKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLWTGY-----SIVPTGDCeVEFFDHFYfTFITSVLEFFIPFISVS 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  217 I----CYTGIIK-----------------TLLRCPSKKKY-------KAIRLIFVIMAVFFIFWTPYNVAILLSSYqsil 268
Cdd:cd15048 181 FfnllIYLNIRKrsrrrplrsvpilpasqNPSRARSQREQvklrrdrKAAKSLAILVLVFLICWAPYTILTIIRSF---- 256
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4502637  269 fgndCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15048 257 ----CSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRK 294
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
41-309 2.88e-16

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 77.98  E-value: 2.88e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   41 YSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-----LVTLPFWIHyvrgHNWVFGHGMCKLLSGFYHT 115
Cdd:cd16002   7 YSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMsafntVINFTYAIH----NEWYYGLEYCKFHNFFPIA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITsiVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSW 195
Cdd:cd16002  83 AVFASIYSMTAIALDRYMAIIHPLQPRLSATATKVVIC--VIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPEHEERKY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRMTIFCLVLPLLVMAICYTGIIKTL----LRCPSKKKY--------KAIRLIFVIMAVFFIFWTPYNVAILLSS 263
Cdd:cd16002 161 ETVYHVCVTVLIYFLPLLVIGCAYTVVGITLwaseIPGDSSDRYheqvsakrKVVKMMIVVVCTFAICWLPYHIYFLLQY 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4502637  264 YQSILFgndceRSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd16002 241 FHPELY-----EQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFR 281
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
70-309 3.09e-16

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 77.91  E-value: 3.09e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   70 NIYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVT 148
Cdd:cd15199  36 AVYLLNLVLADVLLLICLPFKAyFYLNGNRWSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQ 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  149 FGVITSIVTWGLAVLAALPEFIfyeTEELFEETLCSALYPED--TVYSwrhfhTLRMTIFCL--VLPLLVMAICYTGIIK 224
Cdd:cd15199 116 AAPYISFLVWLLLVGLTIPTLL---ASQPKNFTECNSFSPKDdeDFSD-----TWQEAVFFLqfLLPFGLIVFCTVRIIR 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  225 TL---LRCPSK--KKYKAIRLIFVIMAVFFIFWTPYNVA-ILLSSYQSIlfgNDCERSKHLDLVMLVTEVIAYSHCCMNP 298
Cdd:cd15199 188 RLkkrLRDVGKqpKLQRAMALVTSVVVVFGFCFLPCFLArVLMLIFQNK---ESCNALNIAVHTYDVTMCLTYLNSVLDP 264
                       250
                ....*....|.
gi 4502637  299 VIYAFVGERFR 309
Cdd:cd15199 265 IVYCFSSPTFR 275
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
59-303 4.17e-16

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 77.54  E-value: 4.17e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYV-RGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd15118  24 VVGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLaSGHTWELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRCLLVVK 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELF----------EETLCSALYPEDTVYSWRHFHTLRMTIFC 207
Cdd:cd15118 104 PVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIERKdgrklcyynfALFSPSPDNNHPICKQRQEGLAISKLLLA 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  208 LVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILL---SSYQSILFGndcerskHLDLVML 284
Cdd:cd15118 184 FLIPLVIIAVSYAVVSLIIRHRCRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIevmAHNQHSLRP-------LVIQGLP 256
                       250
                ....*....|....*....
gi 4502637  285 VTEVIAYSHCCMNPVIYAF 303
Cdd:cd15118 257 FATTLAFLNSVLNPVLYVF 275
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
60-310 4.40e-16

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 77.01  E-value: 4.40e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   60 IKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd15067  25 LRERYLRTVTNYFIVSLAVADLLVgSIVMPFSIlHEMTGGYWLFGRDWCDVWHSFDVLASTASILNLCVISLDRYWAITD 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVY----SWRHFHtlrmtifclvLPLL 213
Cdd:cd15067 105 PISYPSRMTKRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNQCLFTDDSGYlifsSCVSFY----------IPLV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  214 VMAICYTGIIKTllrcpSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQsilfGNDCerSKHLDLVMLVTEVIAYSH 293
Cdd:cd15067 175 VMLFTYYRIYRA-----AAKEQKAAKTLGIVMGVFILCWLPFFVTNILIGFC----PSNC--VSNPDILFPLVTWLGYIN 243
                       250
                ....*....|....*..
gi 4502637  294 CCMNPVIYAFVGERFRK 310
Cdd:cd15067 244 SGMNPIIYACSSRDFRR 260
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
69-308 5.34e-16

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 76.92  E-value: 5.34e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   69 TNIYLLNLAISDLLFLVTLPFWIHYVRGHNWvfGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIvhaVFALRART-- 146
Cdd:cd15164  35 TRVYMINLAVADCCLLFSLPFVLYFLKHSWP--DDELCLVLQSIYFINRYMSIYIITAIAVDRYIAI---KYPLKAKSlr 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  147 ------VTFGVITSIVTWGLAVLAALPEfifyeteelfeetlcsalyPEDTV-----YSWRHFHTLRMTIFCLVLPLLVM 215
Cdd:cd15164 110 sprkaaLTCGLLWVLVIISVSLRLAWEE-------------------QEENFcfgktSTRPSKRTLIFSLLGFFIPLIIL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  216 AICYTGIIKTLLR----CPSKKK--YKAIRLIFVIMAVFFIFWTPYNVAILLsSYQSILFGNDCERSKHLDLVMLVTEVI 289
Cdd:cd15164 171 SFCSIQVIRSLKKkkktNPHEEKliQKAIYIVSANLIVFIVCFLPLHIGLLV-RFVMESNKASCSLIQNIRNFIYVASCL 249
                       250
                ....*....|....*....
gi 4502637  290 AYSHCCMNPVIYAFVGERF 308
Cdd:cd15164 250 ANANCCLDAICYYFVAKEF 268
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
36-310 1.08e-15

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 76.38  E-value: 1.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYvrgHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15920   2 TLPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRVAY---QNTAGPLSFCKIVGAFFYL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIfyeteelfeetlcSALYPEDTVYSW 195
Cdd:cd15920  79 NMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLF-------------ESRNEGPCDNKC 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRMT--------IFCLVLPLLVMAICYTGIIKTLLRCPS--------KKKYKAIRLIFVIMAVFFIFWTPYNVAI 259
Cdd:cd15920 146 FHFRSKGLTagginltaVVIFYILSLLFLYFYAKISHKLYKVSLgnaqqqikKASKRAIIKTFIVLAIFIVCFVPYHIVR 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 4502637  260 LLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15920 226 VPYVLAQIDVISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRR 276
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
71-312 1.12e-15

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 76.30  E-value: 1.12e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   71 IYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAvFALRARTVTFG 150
Cdd:cd15152  37 IFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMYASIYFLVCISVRRCLYLIYP-FRYNDCKRKCD 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  151 VITSIVTWGLAVLAALPeFIFYETEELFEETLCSALYPEDTVYSwrHFHTLRMTI---FCLVLPLLVMAICYTGII---- 223
Cdd:cd15152 116 VYISIAGWLVVCVGCLP-FPLLRQSQDTNPTCCFADLPLRNVGL--TTSVIMLTIaelTGFVTPLLIVLYCSWKTVmslr 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  224 -KTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYA 302
Cdd:cd15152 193 eKTPVLQDLGEKKKALKMILTCAVVFLICFAPYHISFPLDFLVKSNKIKSCTARKVILIFHPVALCLASLNSCLDPVIYY 272
                       250
                ....*....|
gi 4502637  303 FVGERFRKYL 312
Cdd:cd15152 273 FTTDEFKRRL 282
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
58-312 1.39e-15

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 76.08  E-value: 1.39e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKL------LSGfyhtglYSEIFFIILLTIDR 131
Cdd:cd15079  24 IFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIyaflgsLSG------IGSIWTNAAIAYDR 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  132 YLAIVHAvFALRARTVTFGVITSIVTWGLAVLAALP--EFIFYETEELFEETLCSALYPEDTVysWRHFHTLRMTIFCLV 209
Cdd:cd15079  98 YNVIVKP-LNGNPLTRGKALLLILFIWLYALPWALLplLFGWGRYVPEGFLTSCSFDYLTRDW--NTRSFVATIFVFAYV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  210 LPLLVMAICYTGIIK-------------------TLLRCPSKKKYKA-IRLIFVIMAVFFIF---WTPYNVAILLSsyqs 266
Cdd:cd15079 175 IPLIIIIYCYSFIVKavfahekalreqakkmnvvSLRSNADANKQSAeIRIAKVALTNVFLWfiaWTPYAVVALIG---- 250
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4502637  267 iLFGNdceRSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15079 251 -AFGN---QSLLTPLVSMIPALFAKTAACYNPIVYAISHPKYRLEL 292
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
41-310 2.00e-15

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 75.51  E-value: 2.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   41 YSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:cd15195   7 TWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVtFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  120 EIFFIILLTIDRYLAIVHAVFALRARTVTfgVITSIVTWGLAVLAALPEFIFYETEELF----EETLCSALYPEDTVYSW 195
Cdd:cd15195  87 SSFMLVVIALDRVFAILSPLSANQARKRV--KIMLTVAWVLSALCSIPQSFIFSVLRKMpeqpGFHQCVDFGSAPTKKQE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRMtIFCLVLPLLVMAICYTGIIKTLLRCPS-------------------KKKYKAIRLIFVIMAVFFIFWTPYN 256
Cdd:cd15195 165 RLYYFFTM-ILSFVIPLIITVTCYLLILFEISKMAKrardtpisnrrrsrtnsleRARMRTLRMTALIVLTFIVCWGPYY 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4502637  257 VAILLSSYQSILFGNDcerSKHLDLVMLvteVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15195 244 VLGLWYWFDKESIKNL---PPALSHIMF---LLGYLNPCLHPIIYGVFMKEIRN 291
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
35-312 2.30e-15

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 75.27  E-value: 2.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   35 QFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTnIYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFY 113
Cdd:cd15149   1 RVIPVFYSLVFIVGILLNGVNFWIFFYVPSNKSFI-VYLKNIVFADLLMSLTFPFKIlSDVELGPWQLNVIVCRYSAVIF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  114 HTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFY-ETEELFEETLCSALYPEDTV 192
Cdd:cd15149  80 YLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTnQSFHEANYTKCARLKSELGI 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 YSWRHFHTLRMTIFCLVLPLLVmaICYTGIIKTLL-------RCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQ 265
Cdd:cd15149 160 QWHKASNYICVSIFWVVFLLLI--IFYVAISRKIYksnqkfrRNSTNMKAKSSRNIFSILFVFFVCFVPYHALRIPYTLS 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 4502637  266 SILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15149 238 QTGADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFREML 284
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
37-309 3.56e-15

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 74.83  E-value: 3.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYV-RGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15928   3 VTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLwRYRPWRFGDLLCRLMYFFSET 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHavfALRART-VTFGVITSI--VTWGLAVLAALPEFIFY-----ETEELFEETLCSALY 187
Cdd:cd15928  83 CTYASILHITALSVERYLAICH---PLRAKVlVTRGRVKLLiaVIWAVAIVSAGPALVLVgvehiQGQQTPRGFECTVVN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  188 PED---TVYSWrhfhtlrMTIFCLVLPLLVMAICYTGIIKTL------LRCPSKKKY-----KAIRLIFVIMAVFFIFWT 253
Cdd:cd15928 160 VSSgllSVMLW-------VSTSFFFVPMVCLSLLYGLIGRALwdrrqrSRTAGASRRdnnhrQTVRMLAVIVLAFVLCWL 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  254 PYNVAillssyqSILFGNDCERSKHL----DLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15928 233 PFHVG-------RVIFNHSRASTKHLhyvsQYFNLVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
63-310 6.22e-15

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 73.84  E-value: 6.22e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15329  29 KKLRTPSNYLIVSLAVSDLLVaLLVMPLAIIYELSGYWPFGEILCDVWISFDVLLCTASILNLCAISVDRYLVITRPLTY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALPEFIfyeTEELFEETLCSALYPEDTVYswrhfhTLRMTIFCLVLPLLVMAICYTG 221
Cdd:cd15329 109 AVKRTPKRMALMIAIVWLLSALISIPPLF---GWKNKVNDPGVCQVSQDFGY------QIYATFGAFYIPLIVMLVLYYK 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  222 IIKTllrcpSKKKYKAIRLIFVIMAVFFIFWTPYnvaILLSSYQSILFGNDCERSKH-LDLVMLvteVIAYSHCCMNPVI 300
Cdd:cd15329 180 IYRA-----AKSERKAIKTLGIIMGAFTLCWLPF---FILALLRPFLKPIKCSCIPLwLSRLFL---WLGYANSFLNPII 248
                       250
                ....*....|
gi 4502637  301 YAFVGERFRK 310
Cdd:cd15329 249 YAKFNREFRT 258
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
61-310 1.53e-14

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 72.92  E-value: 1.53e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   61 KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHN-WVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAV 139
Cdd:cd15338  30 KFRCQQTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGvWHFGETMCTLITALDTNSQITSTYILTVMTLDRYLATVHPI 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  140 FALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALY---PEDTVYswrhFHTLRMTIFCLVLPLLVMA 216
Cdd:cd15338 110 RSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGSVGCALLlpnPETDTY----WFTLYQFFLAFALPLVVIC 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  217 ICYTGIIKTLL--------RCPSKKKYKAIRLIFVIMAVFFIFWTPYNVaillssYQSILFGNDcERSKHLDLVMLVTEV 288
Cdd:cd15338 186 VVYFKILQNMAstvaplpqRSLRVRTKKVTRMAVAICLAFFICWAPFYI------LQLAHLSID-RPSLAFLYAYNVAIS 258
                       250       260
                ....*....|....*....|..
gi 4502637  289 IAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15338 259 MGYANSCINPFLYIMLSETFKR 280
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
57-312 1.84e-14

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 72.93  E-value: 1.84e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd15395  23 IIILKQKEMHNVTNILIVNLSFSDLLMtIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITVSIFSLVLIAIERHQLI 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHAV-FALRARTVTFGVitsIVTWGLAVLAALPEFIFYETE------------ELFEETLCSALYPEDTVyswRHFHTLR 202
Cdd:cd15395 103 INPRgWRPNNRHAYVGI---AVIWVLAVLTSLPFLIFQVLTdepfknvnvsldAYKGKYVCLDQFPSDTI---RLSYTTC 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  203 MTIFCLVLPLLVMAICYTGIIKTLLRCPS------KKKYKAIR------LIFVIMAVFFIFWTPYNVAILLSSYQSILFG 270
Cdd:cd15395 177 LLVLQYFGPLCFIFICYLKIYIRLKRRNNmmdkmrDNKYRSSEtkriniMLISIVVAFAVCWLPLNIFNAVFDWNHEAIA 256
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4502637  271 NdCerskHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15395 257 T-C----NHNLLFLICHLTAMISTCVNPIFYGFLNKNFQRDL 293
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
57-310 2.01e-14

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 72.47  E-value: 2.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKY---RRLRIMTNIYLLNLAISDLLF-LVTLPFW-IHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDR 131
Cdd:cd15302  20 LVLLSFyvdRNIRQPSNYFIASLAVSDLLIgLESMPFYtVYVLNGDYWPLGWVLCDLWLSVDYTVCLVSIYTVLLITIDR 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  132 YLAIVHAVFALRARTVTFGVITSIVTWglaVLAALPEFIFYE-------TEELFEETLCSALYPEDTVYSwrhfhtLRMT 204
Cdd:cd15302 100 YCSVKIPAKYRNWRTPRKVLLIIAITW---IIPALLFFISIFgwqyftgQGRSLPEGECYVQFMTDPYFN------MGMY 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  205 IFCLVLPLLVMAICYTGIIKTllrcpSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHL-DLVM 283
Cdd:cd15302 171 IGYYWTTLIVMLILYAGIYRA-----ANRARKALRTITFILGAFVICWTPYHILATIYGF--------CEAPPCVnETLY 237
                       250       260
                ....*....|....*....|....*..
gi 4502637  284 LVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15302 238 TISYYLCYMNSPINPFCYALANQQFKK 264
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
35-303 3.16e-14

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 72.07  E-value: 3.16e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   35 QFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRImtNIYLLNLAISDLL--FLVTLPFWIHYVRGhNWVFGHGMCKLLSGF 112
Cdd:cd15197   3 QLATLWVLFVFIVVGNSSVLFALWMRKAKKSRM--NFFITQLAIADLCvgLINVLTDIIWRITV-EWRAGDFACKVIRYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  113 YHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITsiVTWGLAVLAALPEFIFYETEELFE-ETLCSALYPEDt 191
Cdd:cd15197  80 QVVVTYASTYVLVALSIDRYDAICHPMNFSQSGRQARVLIC--VAWILSALFSIPMLIIFEKTGLSNgEVQCWILWPEP- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  192 vYSWRHFHTLrMTIFCLVLPLLVMAICYTGIIKTLLR-------------------------CPSKKKYKAIRLIFVIMA 246
Cdd:cd15197 157 -WYWKVYMTI-VAFLVFFIPATIISICYIIIVRTIWKkskiqvtinkaglhdgssrrsssrgIIPRAKIKTIKMTFVIVT 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4502637  247 VFFIFWTPYNVAILLSSYqsilfgNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAF 303
Cdd:cd15197 235 VFIICWSPYFVFDLLDVF------GLLPRSKTKIAAATFIQSLAPLNSAINPLIYCL 285
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
58-303 5.93e-14

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 71.34  E-value: 5.93e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLL-FLVTLPF-WIHYVRGHNWVFGHGMCkLLSGFYHTGL-YSEIFFIILLTIDRYLA 134
Cdd:cd15212  24 VIVKHRQLRTVTNAFILSLSLSDLLtALLCLPFaFLTLFSRPGWLFGDRLC-LANGFFNACFgIVSTLTMTLISFDRYYA 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  135 IV----HAVFALRARTVTFGVITSIVTWGLA--VLAALPEFIFYETEELFEETLCSALYPEDTVYSwrhfhtLRMTIFCL 208
Cdd:cd15212 103 IVrqpqGKIGRRRALQLLAAAWLTALGFSLPwyLLASAPEYYEKLGFYHCLYVLHSGPSRLGAAYS------SVLIVLCY 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  209 VLPLLVMAICYTGIIKTLLRC-----PSKKKYKAIRL--------IFVIMAVFFIF-WTPYNVAILLSSYQSILFgndce 274
Cdd:cd15212 177 LLPFALMCFCHYNICKTVRLSesrvrPVTTYAHLLRFysemrtatTVLIMIVFIICcWGPYCLLGLVAAAGGYQF----- 251
                       250       260
                ....*....|....*....|....*....
gi 4502637  275 rSKHLDLVMLvteVIAYSHCCMNPVIYAF 303
Cdd:cd15212 252 -PPLMDTVAI---WMAWANGAINPLIYAI 276
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
57-312 6.80e-14

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 71.01  E-value: 6.80e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd15391  23 VVFYDGRRSRTDLNYYLINLAVSDLIMaLFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGIDRFFAV 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHAVFALRARTVTFGVITSIvtWGLAVLAALPEFIF----YETEELFEETLCSALYPEDTvySWRHFHTLRMTIFCLVLP 211
Cdd:cd15391 103 IFPLRSRHTKSRTKCIIASI--WAISFSLSSVQLFAgrtqRYGQYSEGRVLCGESWPGPD--TSRSAYTVFVMLLTYIIP 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  212 LLVMAICYTGIIKTLL-------------RCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqSILFGNDCERSKH 278
Cdd:cd15391 179 LLILTSTYGYVGFRLWnrtapgnadkgrdDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNLVQDF-STVFRNMPQHTTR 257
                       250       260       270
                ....*....|....*....|....*....|....
gi 4502637  279 ldLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15391 258 --LIYGACHWIAMSNSFVNPIIYLFMNDSFRSIL 289
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
36-310 7.61e-14

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 70.96  E-value: 7.61e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYV-RGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15364   2 FLVVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVsNNHKWPWGSLACKITGYIFF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIfYETEELFEETLCSALYPEDTVYS 194
Cdd:cd15364  82 CNIYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFI-MREGQTEGSHTCFETLQMDTQVA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 wrHFHTLRMTI-FCLVLPLLVMAICYT-GIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGND 272
Cdd:cd15364 161 --GFYYARFCIgFAIPLAILIFTNYRIfRSIQTSTSLTPHQKAKVKYLAIAVIVIFLICFAPYHLVLLVRAIAFSLYPNG 238
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4502637  273 -CERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15364 239 mCGFEERIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQ 277
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
61-301 8.70e-14

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 70.93  E-value: 8.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   61 KYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAV 139
Cdd:cd15384  27 RLRRSRRTIYSLLLHLAIADLLVtFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLSTYITVLISLDRCVAILYPM 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  140 FALRARTVTFGVITsiVTWGLAVLAALPEFI---FYETEELFEETLCSALYPEDTVYSWRHFHTLRMtIFCLVLPLLVMA 216
Cdd:cd15384 107 KRNQAPERVRRMVT--VAWILSPIFSIPQAVifhVERGPFVEDFHQCVTYGFYTAEWQEQLYNMLSL-VFMFPIPLVIMV 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  217 ICYTGIIKTLL---------------------RCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLssyqsILFGNDCER 275
Cdd:cd15384 184 TCYVLIFITLSkssrdfqgleiytrnrgpnrqRLFHKAKVKSLRMSAVIVTAFILCWTPYYVIMIW-----FLFFNPYPL 258
                       250       260
                ....*....|....*....|....*.
gi 4502637  276 SkhlDLVMLVTEVIAYSHCCMNPVIY 301
Cdd:cd15384 259 N---DILFDVIFFFGMSNSCVNPLIY 281
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
58-310 9.45e-14

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 70.62  E-value: 9.45e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSgfYHTGLYSEIFFIILLTI--DRYLA 134
Cdd:cd15399  24 VVIKFKNMRTVTNFFIANLAVADLMVnTLCLPFTLVYTLLDEWKFGAVLCHLVP--YAQALAVHVSTVTLTVIalDRHRC 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  135 IVHAVFALRARTVTFGVITsiVTWGLAVLAALP-----EFIFYETEELFEETLCSALYPEDTVySWRHFHTLRMTIFCLV 209
Cdd:cd15399 102 IVYHLESKISKKISFLIIG--LTWAASALLASPlaifrEYSVIEISPDFKIQACSEKWPNGTL-NDGTIYSVSMLLIQYV 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  210 LPLLVMAICYTGIIKTLLRCPS---------KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFgndceRSKHLD 280
Cdd:cd15399 179 LPLAIISYAYIRIWTKLKNHVSpgggndhyhQRRRKTTKMLVCVVVVFAVSWLPFHAFQLASDIDSKVL-----DLKEYK 253
                       250       260       270
                ....*....|....*....|....*....|
gi 4502637  281 LVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15399 254 LIYTIFHVIAMCSTFANPLLYGWMNNNYRT 283
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
58-310 1.42e-13

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 70.44  E-value: 1.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYV-RGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd15134  24 VIARNRSMHTATNYYLFSLAVSDLLLLILgLPFELYTIwQQYPWVFGEVFCKLRAFLSEMSSYASVLTITAFSVERYLAI 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPE-------DTVYSWRHFHTLRMTIFcL 208
Cdd:cd15134 104 CHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRIVYLEYPPTSGEALEEsafcamlNEIPPITPVFQLSTFLF-F 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  209 VLPLLVMAICYTGI---IK--TLLRCPSKKKYKA----------IRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDC 273
Cdd:cd15134 183 IIPMIAIIVLYVLIglqLRrsTLLRRGQRSVSGGrrssqsrrtvLRMLVAVVVAFFICWAPFHAQRLLTVYAKNMTPPYL 262
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4502637  274 ERSKHLDlvmLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15134 263 FINRILF---YISGVLYYVSSTVNPILYNVMSAKYRQ 296
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
40-310 1.56e-13

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 70.11  E-value: 1.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd15148   6 FYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYhVNNNQWTLGPLLCKVVGNLFYMNMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIfyeteelfeetlcSALYPEDTV----YS 194
Cdd:cd15148  86 ISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMIV-------------LTEKNEESTkcfqYK 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRH-------FHTLRMTIFCLVLPLLVMAicYTGIIKTLLRCPSKK-------KY-KAIRLIFVIMAVFFIFWTPYN-VA 258
Cdd:cd15148 153 DRKnakgkaiFNFLIVAMFWLVFLLLILS--YGKIAKKLLRISRDKpdfpnaaKYnRTARKSFFVLFIFTVCFVPYHaFR 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 4502637  259 ILLSSYQsiLFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15148 231 IFYITSQ--LQNNSCYWKEILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIRK 280
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
43-310 1.57e-13

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 69.81  E-value: 1.57e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   43 LVFTVGLLGNVVVVMILIKYR--RLRIMTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKlLSGFYhTGL-- 117
Cdd:cd15209   7 LIVTIVVDVLGNLLVILSVLRnkKLRNAGNIFVVSLSVADLVVAIyPYPLILHAIFHNGWTLGQLHCQ-ASGFI-MGLsv 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  118 YSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYswrh 197
Cdd:cd15209  85 IGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFFIGSLQYDPRIYSCTFAQTVSTVY---- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  198 fhTLRMTIFCLVLPLLVMAICYTGI------IKTLLRCPSKKKYKAIRL-----IFVIMAVFFIFWTPYNVAILLSSYqs 266
Cdd:cd15209 161 --TITVVVIHFLLPLLIVSFCYLRIwvlvlqVRQRVKPDQRPKLKPADVrnfltMFVVFVLFAVCWAPLNFIGLAVAI-- 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 4502637  267 ilfgNDCERSKHLDLVMLVTE-VIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15209 237 ----NPKEMAPKIPEWLFVASyFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
57-310 1.81e-13

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 69.57  E-value: 1.81e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYL--LNLAISDLL--FLVTLPFWI----HYVRGHNWvfghgMCKLLSGFYHTGLYSEIFFIILLT 128
Cdd:cd15196  21 VLLVLYRRRRKLSRMHLfiLHLSVADLLvaLFNVLPQLIwditYRFYGGDL-----LCRLVKYLQVVGMYASSYVLVATA 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  129 IDRYLAIVHAVFALRARTVTFGViTSIVTWGLAVLAALPE-FIFYETEELFEETLCSALYPEDTV---YSWRHFhtlrMT 204
Cdd:cd15196  96 IDRYIAICHPLSSHRWTSRRVHL-MVAIAWVLSLLLSIPQlFIFSYQEVGSGVYDCWATFEPPWGlraYITWFT----VA 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  205 IFclVLPLLVMAICYTGIIKTLLRcpskKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHLDLVML 284
Cdd:cd15196 171 VF--VVPLIILAFCYGRICYVVWR----AKIKTVKLTLVVVACYIVCWTPFFVVQMWAAW--------DPTAPIEGPAFV 236
                       250       260
                ....*....|....*....|....*..
gi 4502637  285 VTEVIAYSHCCMNPVIY-AFVGERFRK 310
Cdd:cd15196 237 IIMLLASLNSCTNPWIYlAFSGNLRRA 263
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
63-310 1.87e-13

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 69.38  E-value: 1.87e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15050  29 RKLHTVGNLYIVSLSVADLIVgAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALP----EFIFYETEELFEETLCSALYPEDTVYSwrhfhtLRMTIFCLVLPLLVMAI 217
Cdd:cd15050 109 LKYRTKTRASLMISGAWLLSFLWVIPilgwHHFARGGERVVLEDKCETDFHDVTWFK------VLTAILNFYIPSLLMLW 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  218 CYTGIIKTLlrcpsKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHLDLVMlVTEVIAYSHCCMN 297
Cdd:cd15050 183 FYAKIFKAV-----NRERKAAKQLGFIMAAFILCWIPYFILFMVIAF--------CKNCCNENLHM-FTIWLGYINSTLN 248
                       250
                ....*....|...
gi 4502637  298 PVIYAFVGERFRK 310
Cdd:cd15050 249 PFIYPLCNENFKK 261
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
63-309 2.99e-13

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 68.88  E-value: 2.99e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWI-HYVRGHNWVFGHGMCKL---LSGFYHTglySEIFFIILLTIDRYLAIVH 137
Cdd:cd15052  29 KRLQNVTNYFLMSLAIADLLVgLLVMPLSIlTELFGGVWPLPLVLCLLwvtLDVLFCT---ASIMHLCTISLDRYMAIRY 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELfeetlcSALYPEDTVYSWRHFhTLRMTIFCLVLPLLVMAI 217
Cdd:cd15052 106 PLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDTT------NVLNNGTCVLFNPNF-VIYGSIVAFFIPLLIMVV 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  218 CYTGIIKTLLRcpskkKYKAIRLIFVIMAVFFIFWTPYNVAILLSSyqsilFGNDCErSKHLDLVMLVTEVIAYSHCCMN 297
Cdd:cd15052 179 TYALTIRLLSN-----EQKASKVLGIVFAVFVICWCPFFITNILTG-----LCEECN-CRISPWLLSVFVWLGYVSSTIN 247
                       250
                ....*....|..
gi 4502637  298 PVIYAFVGERFR 309
Cdd:cd15052 248 PIIYTIFNKTFR 259
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
57-309 6.91e-13

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 68.29  E-value: 6.91e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYV-RGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd15132  23 LIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRLwKSRPWIFGEFLCRLYHYISEGCTYATILHITALSIERYLAI 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 vhaVFALRART-VTFGVITSIVT--WGLAVLAALPEFIFYETEELFEEtlcsalypEDTVYSWRHFHTLR---------- 202
Cdd:cd15132 103 ---CFPLRAKVlVTRRRVKCVIAalWAFALLSAGPFLFLVGVEQDNNI--------HPDDFSRECKHTPYavssgllgim 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  203 --MTIFCLVLPLLVMAICYTGIIKTL------LRCPS-----KKKYKAIRLIFVIMAVFFIFWTPYNVAILL----SSYQ 265
Cdd:cd15132 172 iwVTTTYFFLPMLCLSFLYGFIGRKLwkskndLRGPNaaareRSHRQTVRILAVVVLAFIICWLPFHIGRILfantEDYR 251
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4502637  266 SILFgndcerSKHLDLVMLvteVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15132 252 TMMF------SQYFNIVAM---QLFYLSASINPILYNLISRKYR 286
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
40-309 7.34e-13

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 67.86  E-value: 7.34e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRG-HNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd15167   6 FYYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAVDLGiAPWKLKIFHCQVTACLIYINMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTvysWRHF 198
Cdd:cd15167  86 LSIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPNMAIPIKTIEEKPGVGCADFKTEF---GRHW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  199 HTLRMTIfCLVLPLLVMAICYTG---IIKTLLRCPSKKKY----KAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGN 271
Cdd:cd15167 163 HVLTNFI-CMAIFLNFSAIILISnflVIRKLYRNKDSEEYrnarQALVNILLVTAGYVICFVPYHIVRIPYTLSQSEVIT 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4502637  272 DCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15167 242 DCSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFR 279
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
57-309 8.15e-13

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 67.99  E-value: 8.15e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHN-WVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd15131  23 LVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRpWNFGDLLCKLFQFVSESCTYSTILNITALSVERYFAI 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 vhaVFALRA-RTVTFGVITS--IVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLV--- 209
Cdd:cd15131 103 ---CFPLRAkVVVTKRRVKLviLVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNECKATEYAVRSGLLTIMVWVSSVfff 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  210 LPLLVMAICYTGIIKTLLR--------CPS---KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSilFGNDCERSKH 278
Cdd:cd15131 180 LPVFCLTVLYSLIGRKLWRrrrenigpNAShrdKNNRQTVKMLAVVVFAFVLCWLPFHVGRYLFSKSF--EAGSLEIALI 257
                       250       260       270
                ....*....|....*....|....*....|.
gi 4502637  279 LDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15131 258 SQYCNLVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
37-312 9.02e-13

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 67.89  E-value: 9.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTnIYLLNLAISDLLFLVTLPFWIHYVRGHN-WVFGHGMCKLLSGFYHT 115
Cdd:cd15969   3 FPVLYLIIFIGSILLNGLAVWIFFHIRNKTSFI-FYLKNIVIADLLMTLTFPFKIIQDSGLGpWNFNFFLCRYTSVLFYA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETL-CSALYPEDTVyS 194
Cdd:cd15969  82 SMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILTNGQPTEDNIHdCSKLKSPLGV-K 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WrHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLR------CPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIL 268
Cdd:cd15969 161 W-HTAVSYINICIFVAVLVILIVCYISISRYIYKsskqfiSSSSRTRKHNQSIRVVVAVFFVCFLPYHLCRIPFTFSQLD 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4502637  269 FGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15969 240 KILDCTIKTILYYCKEATLFLSACNVCLDPIIYFFMCRSFSQRL 283
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
40-309 1.03e-12

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 67.58  E-value: 1.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLV-TLPFWIHYV-RGHNWVFGHGMCKLLSGFYHTGL 117
Cdd:cd15357   6 VYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLfGMPLEVYEMwSNYPFLFGPVGCYFKTALFETVC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  118 YSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEfiFYETEELFEETLCSALYPEDTVYS--- 194
Cdd:cd15357  86 FASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPN--TSIHGIKLQYFPNGTLIPDSATCTvvk 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 --WRHFHTLRMTIFCL-VLPLLVMAICY--------------TGIIKTLLRCPSKKkyKAIRLIFVIMAVFFIFWTPYNV 257
Cdd:cd15357 164 plWIYNLIIQITSLLFyVLPMGVISVLYylmglklrgdksleADEMNVNIQRPSRK--SVTKMLFVLVLVFAICWAPFHV 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 4502637  258 AILLSSYQSILFGndcERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15357 242 DRLFFSFVVEWTE---PLANVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFR 290
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
61-255 1.08e-12

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 67.78  E-value: 1.08e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   61 KYRRLRIMTNIYLLNLAISDLLF-LVTLPF---WIHYVRghnWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV 136
Cdd:cd15383  28 NRRRKLSHVRILILHLAAADLLVtFVVMPLdaaWNVTVQ---WYAGDLACRLLMFLKLFAMYSSAFVTVVISLDRHAAIL 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HAVFALRARTVtfGVITSIVTWGLAVLAALPE---FIFYETEELFEETLCS--ALYP---EDTVYSWRHFHTLrmtifcL 208
Cdd:cd15383 105 NPLAIGSARRR--NRIMLCAAWGLSALLALPQlflFHTVTATPPVNFTQCAthGSFPahwQETLYNMFTFFCL------F 176
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502637  209 VLPLLVMAICYTGII----------------KTLLRCPS----KKKYKAIRLIFVIMAVFFIFWTPY 255
Cdd:cd15383 177 LLPLLIMIFCYTRILleisrrmkekkdsaknEVALRSSSdnipKARMRTLKMTIVIVSSFIVCWTPY 243
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
56-310 1.08e-12

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 67.35  E-value: 1.08e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   56 VMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLA 134
Cdd:cd15064  22 IAAILLTRKLHTPANYLIASLAVADLLVaVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASILHLCVIALDRYWA 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  135 IVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCsalypedtVYSWRHFHTLRMTIFCLVLPLLV 214
Cdd:cd15064 102 ITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSEC--------LISQDIGYTIFSTFGAFYIPLLL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  215 MAICYTGIIKTllrcpSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHLDLVMLVTEVIAYSHC 294
Cdd:cd15064 174 MLILYWKIYRA-----AARERKAAKTLGIILGAFIVCWLPFFLVALIVPL--------CSHCWIPLALKSFFLWLGYFNS 240
                       250
                ....*....|....*.
gi 4502637  295 CMNPVIYAFVGERFRK 310
Cdd:cd15064 241 LINPLIYTFFNKDFRK 256
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
63-309 1.55e-12

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 66.93  E-value: 1.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15330  29 RSLQNVANYLIGSLAVTDLMVSVlVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEEtlcsalyPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTG 221
Cdd:cd15330 109 VNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPEDRSD-------PDACTISKDPGYTIYSTFGAFYIPLILMLVLYGR 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  222 IIKTLLRcpskkKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHL-DLVMLVTEVIAYSHCCMNPVI 300
Cdd:cd15330 182 IFKAAAR-----ERKTVKTLGIIMGTFILCWLPFFIVALVLPF--------CESTCHMpELLGAIINWLGYSNSLLNPII 248

                ....*....
gi 4502637  301 YAFVGERFR 309
Cdd:cd15330 249 YAYFNKDFQ 257
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
40-309 8.31e-12

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 64.71  E-value: 8.31e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVT--LPFWIHYVRGHN-WVFGHGMCKLLSGFYHTG 116
Cdd:cd14995   6 LVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAagLPNEIESLLGPDsWIYGYAGCLLITYLQYLG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  117 LYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFE--ETLCSALYPEDTVYs 194
Cdd:cd14995  86 INASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKHYgdDIVVRCGYKVSRHY- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFcLVLPLLVMAICYTGIIKTLlrcpSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNdce 274
Cdd:cd14995 165 YLPIYLADFVLF-YVIPLLLAIVLYGLIGRIL----FSSRKQVTKMLAVVVVLFALLWMPYRTLVVYNSFASPPYLD--- 236
                       250       260       270
                ....*....|....*....|....*....|....*
gi 4502637  275 rskhlDLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd14995 237 -----LWFLLFCRTCIYLNSAINPILYNLMSQKFR 266
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
60-310 1.10e-11

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 64.74  E-value: 1.10e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   60 IKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLSgfYHTGLYSEIFFIILLTI--DRYLAIV 136
Cdd:cd15336  26 CRSKKLRTPANYFIINLAVSDFLMSLTqSPIFFVNSLHKRWIFGEKGCELYA--FCGALFGITSMITLLAIslDRYLVIT 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYeteelfeetlcSALYPED--TVYSWRHF------HTLRMTIFCL 208
Cdd:cd15336 104 KPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGW-----------SAYVPEGllTSCTWDYMtftpsvRAYTMLLFCF 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  209 V--LPLLVMAICYTGI----------IKTLLRCPSKKK----------YKAIRLIFVIMAVFFIFWTPYNVAILLS--SY 264
Cdd:cd15336 173 VffIPLGIIIYCYLFIflairstgreVQKLGSQDRKEKakqyqrmkneWKMAKIAFVVILLFVLSWSPYACVALIAwaGY 252
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4502637  265 QSIL--FGNDcerskhldlvmlVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15336 253 AHLLtpYMKS------------VPAVIAKASAIYNPIIYAITHPKYRE 288
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
59-310 1.11e-11

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 64.21  E-value: 1.11e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRIMTNIYLLNLAISDLLFLVT-LPF-WIHYVRGHnWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV 136
Cdd:cd15210  25 LLRSKKLRTRTNAFIINLSISDLLFCAFnLPLaASTFLHQA-WIHGETLCRVFPLLRYGLVAVSLLTLVLITLNRYILIA 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HAVFALRARTVTFGVITSIVTW--GLAVLAALPEFIFYETEELFEETLCSALYPEDtvyswRHFHTLRMTIFCLVLPLLV 214
Cdd:cd15210 104 HPSLYPRIYTRRGLALMIAGTWifSFGSFLPLWLGIWGRFGLDPKVCSCSILRDKK-----GRSPKTFLFVFGFVLPCLV 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  215 MAICYTgiiktllrcpSKKKYKAIRLIFVIMAVFFIFWTPY---NVAILLSSYQSIlfgndcerskhldlvMLVTEVIAY 291
Cdd:cd15210 179 IIICYA----------RREDRRLTRMMLVIFLCFLVCYLPItlvNVFDDEVAPPVL---------------HIIAYVLIW 233
                       250
                ....*....|....*....
gi 4502637  292 SHCCMNPVIYAFVGERFRK 310
Cdd:cd15210 234 LSSCINPIIYVAMNRQYRQ 252
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
68-310 1.34e-11

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 64.10  E-value: 1.34e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   68 MTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRART 146
Cdd:cd15215  33 VANRFIFNLLVADLLQTVlVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMT 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  147 VTFGVITSIVTWGLAVLAALPE-FIFYETEELFEETLCSALYPEDTVYswrhfhTLRMTIFCLVLPLLVMAICYTGIIKT 225
Cdd:cd15215 113 PRRGYLLIYGTWIVSVLQSTPPlYGWGQAAFDERNALCSVIWGSSYSY------TILSVVSSFVLPVIIMLACYSMVFRA 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  226 LLRCpskKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSilfgndcerSKHLDLVMLVTEVIAYSHCCMNPVIYAFVG 305
Cdd:cd15215 187 ARRC---YHCKAAKVIFIIIFSYVLSMGPYSFLSVLAVWVD---------TQVPQWVISIILWLFFLQCCIHPYIYGYMH 254

                ....*
gi 4502637  306 ERFRK 310
Cdd:cd15215 255 KSIKK 259
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
54-310 1.49e-11

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 64.37  E-value: 1.49e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   54 VVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPfWIHYVRG--HNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDR 131
Cdd:cd15000  19 VLLYILASNRSLRTPTNLLIGNMALADLLTLLVCP-WMFLVHDffQNYVLGSVGCKLEGFLEGSLLLASVLALCAVSYDR 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  132 YLAIvhaVFALRARTVTFGV-ITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLrmtIFCLV- 209
Cdd:cd15000  98 LTAI---VLPSEARLTKRGAkIVIVITWIVGLLLALPLAIYRSYRERQWKNFLETYCAENTQVLPIYWHVI---ITVLVw 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  210 LPLLVMAICYTGII-------KTLLRC--PSKKKYK--AIRLIFVIMAVFFIFWTPYNVAILlssYQSILFGNDCERSKH 278
Cdd:cd15000 172 LPLGIMLICYSAIFwkldkyeRRVLRRehPSVVRYKkkAAKTLFIVLITFVVCRIPFTALIF---YRYKLVPNDNTQNSV 248
                       250       260       270
                ....*....|....*....|....*....|....*
gi 4502637  279 LDLVML---VTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15000 249 SGSFHIlwfASKYLMFLNAAVNPLIYGFTNENFRK 283
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
57-310 1.72e-11

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 63.69  E-value: 1.72e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYR---RLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRY 132
Cdd:cd15301  20 MVMISFKidkQLQTISNYFLFSLAVADFAIgVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLLIISFDRY 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  133 LAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETlcsalyPEDTVY----SWRHFHTLRMTIFCL 208
Cdd:cd15301 100 FSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIYSWPYIEGKRTV------PAGTCYiqflETNPYVTFGTALAAF 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  209 VLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIlfgNDCERSKHLDLVMLvtev 288
Cdd:cd15301 174 YVPVTIMCILYWRIWRETKKRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFFPC---SDTIPTELWDFSYY---- 246
                       250       260
                ....*....|....*....|..
gi 4502637  289 IAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15301 247 LCYINSTINPLCYALCNAAFRR 268
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
62-310 1.76e-11

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 63.60  E-value: 1.76e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   62 YRRLRIMTNIYLLNLAISDL-LFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVF 140
Cdd:cd15060  28 YRPLRIVQNFFIVSLAVADLaVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTASILNLCAIALDRYWAIHDPIN 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  141 ALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYswrhfhTLRMTIFCLVLPLLVMAICYT 220
Cdd:cd15060 108 YAQKRTLKRVLLMIVVVWALSALISVPPLIGWNDWPENFTETTPCTLTEEKGY------VIYSSSGSFFIPLLIMTIVYV 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  221 GIiktlLRCPSKKKyKAIRLIFVIMAVFFIFWTPYNVAillssYQSILFGNDCERSKHLDLVMLvteVIAYSHCCMNPVI 300
Cdd:cd15060 182 KI----FIATSKER-RAARTLGIIMGVFVVCWLPFFLM-----YVILPFCETCSPSAKVVNFIT---WLGYVNSALNPVI 248
                       250
                ....*....|
gi 4502637  301 YAFVGERFRK 310
Cdd:cd15060 249 YTIFNLDFRR 258
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
37-310 2.00e-11

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 63.77  E-value: 2.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd15124   3 IPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYLADEWLFGRVGCKLIPFIQLT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIF-----YETEELFEETLCSALYPED 190
Cdd:cd15124  83 SVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFsdlhpFYDKSTNKTFVSCAPYPHS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  191 TVYSWRhFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPS--------------KKKYKAIRLIFVIMAVFFIFWTPYN 256
Cdd:cd15124 163 NELHPK-IHSMASFLIFYVIPLSIISVYYYFIAKNLIRSAYnlpvegnvhvrrqiESRKRLAKTVLVFVGLFAFCWLPNH 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4502637  257 VAILLSSYQSilfgNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15124 242 IIYLYRSYHY----SEVDTSMLHFVSSICARILAFTNSCVNPFALYLLSKSFRK 291
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
41-312 2.06e-11

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 63.79  E-value: 2.06e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   41 YSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:cd15123   7 YAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  120 EIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELF-----EETLCSALYPEDTVYs 194
Cdd:cd15123  87 SVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRdpeknTTFEACAPYPVSEKI- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 WRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRC----PSKK----------KYKAIRLIFVIMAVFFIFWTPYNVAIL 260
Cdd:cd15123 166 LQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYKStfnmPAEEhsharkqiesRKRVAKTVLVLVALFAFCWLPNHILYL 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 4502637  261 lssYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15123 246 ---YRSFTYHTSVDSSAFHLIATIFSRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
62-310 2.10e-11

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 63.73  E-value: 2.10e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   62 YRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAvf 140
Cdd:cd15055  28 FKQLHTPTNLLLLSLAVADFLVgLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDP-- 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  141 aLRART-VTFGVITSIVT--WGLAVLAALPEFIFYETEELFEETL-----CSALYPedtvYSWRHFHTlrmtIFCLVLPL 212
Cdd:cd15055 106 -LLYPTkITIRRVKICIClcWFVSALYSSVLLYDNLNQPGLIRYNscygeCVVVVN----FIWGVVDL----VLTFILPC 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  213 LVMAICYTGI----------IKTLLRCPS----------KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFgnd 272
Cdd:cd15055 177 TVMIVLYMRIfvvarsqaraIRSHTAQVSlegsskkvskKSERKAAKTLGIVVGVFLLCWLPYYIVSLVDPYISTPS--- 253
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4502637  273 cerskhldLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15055 254 --------SVFDVLIWLGYFNSCLNPLIYALFYPWFRK 283
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
60-310 2.91e-11

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 63.60  E-value: 2.91e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   60 IKYRRLRI-MTNIYLLNLAISDLLFLVTLPFW--IHYVRGHnWVFGhGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV 136
Cdd:cd15057  26 LRFRHLRSkVTNYFIVSLAVSDLLVAILVMPWaaVNEVAGY-WPFG-SFCDVWVSFDIMCSTASILNLCVISVDRYWAIS 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HAVFALRARTVTFGVITSIVTWGLAVLAA-LPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVM 215
Cdd:cd15057 104 SPFRYERRMTRRRAFIMIAVAWTLSALISfIPVQLGWHRADDTSEALALYADPCQCDSSLNRTYAISSSLISFYIPVAIM 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  216 AICYTGI----------IKTL-------------LRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVA-ILLSSYQSILFGN 271
Cdd:cd15057 184 IVTYTRIyriarrqirrIAALeraaqestnpdssLRSSLRRETKALKTLSIIMGVFVCCWLPFFILnCVLPFCDLRTAQF 263
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4502637  272 DCERskhlDLVMLVTEVIAYSHCCMNPVIYAFVGErFRK 310
Cdd:cd15057 264 PCVP----DTTFIVFVWLGWANSSLNPIIYAFNAD-FRK 297
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
59-309 3.24e-11

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 62.77  E-value: 3.24e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRR--LRIMTNIYLLNLAISD-LLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd15213  23 LIVYQKpaMRSAINLLLANLAFSDiMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLII 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHAVFALRARTVTfgvITSIVTWGLAVLAALPEFI-FYETEELFEETLCSALYPEDTVYswrHFHTLRMTIFCLVLPLLV 214
Cdd:cd15213 103 VQRQDKLNPHRAK---ILIAVSWVLSFCVSFPPLVgWGKYEFPPRAPQCVLGYTESPAD---RIYVVLLLVAVFFIPFLI 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  215 MAICYTGIIKTLlrcpSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNdCERSKHLDLvmlvtevIAYSHC 294
Cdd:cd15213 177 MLYSYFCILNTV----RSFKTRAFTTILILFIGFSVCWLPYTVYSLLSVFSRYSSSF-YVISTCLLW-------LSYLKS 244
                       250
                ....*....|....*
gi 4502637  295 CMNPVIYAFVGERFR 309
Cdd:cd15213 245 AFNPVIYCWRIKKFR 259
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
59-310 3.28e-11

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 63.04  E-value: 3.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRIMTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd15334  25 IIVTRKLHHPANYLICSLAVTDFLVAVlVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITD 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETeelfeetlcsALYPEDTVYSwRHFH---TLRMTIFCLVLPLLV 214
Cdd:cd15334 105 AVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQ----------TTSREDECII-KHDHivfTIYSTFGAFYIPLAL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  215 MAICYTGIIKTLLRcpskkKYKAIRLIFVIMAVFFIFWTPYNVAILLSsyqsilfgNDCERSKHLDLVMLVTEVIAYSHC 294
Cdd:cd15334 174 ILILYYKIYRAATR-----ERKAATTLGLILGAFVICWLPFFVKEVIV--------NTCDSCYISEEMSNFLTWLGYINS 240
                       250
                ....*....|....*.
gi 4502637  295 CMNPVIYAFVGERFRK 310
Cdd:cd15334 241 LINPLIYTIFNEDFKK 256
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
63-310 3.53e-11

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 62.72  E-value: 3.53e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15049  29 RQLRTVNNYFLLSLACADLIIgLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALPEFI---FYETEELFEETLCSALYPEDTVYswrhfhTLRMTIFCLVLPLLVMAIC 218
Cdd:cd15049 109 RAKRTPKRAILMIALAWVISFVLWAPAILgwqYFVGERTVPDGQCYIQFLDDPAI------TFGTAIAAFYLPVLVMTIL 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  219 YTGIIKTllrcpSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSyqsilFGNDCERskhlDLVMLVTEVIAYSHCCMNP 298
Cdd:cd15049 183 YWRIYRE-----TARERKAARTLSAILLAFIITWTPYNILVLVST-----FCAKCIP----DTLWSFGYWLCYINSTINP 248
                       250
                ....*....|..
gi 4502637  299 VIYAFVGERFRK 310
Cdd:cd15049 249 FCYALCNKTFRK 260
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
43-310 4.52e-11

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 62.62  E-value: 4.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   43 LVFTVGLLGNVVVVMIL--IKYRRLRIMTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:cd15401   7 LIFTIVVDVLGNLLVILsvLRNKKLRNAGNIFVVSLSVADLVVAVyPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  120 EIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYswrhfh 199
Cdd:cd15401  87 SVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNFFVGSLQYDPRIYSCTFAQTVSSSY------ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  200 TLRMTIFCLVLPLLVMAICYTGI------IKTLLRCPSKKKYKAIRL-----IFVIMAVFFIFWTPYNVAILLSSYqsil 268
Cdd:cd15401 161 TITVVVVHFIVPLSIVTFCYLRIwvlviqVKHRVRQDSKQKLKANDIrnfltMFVVFVLFAVCWGPLNFIGLAVAI---- 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4502637  269 fgNDCERSKHLDLVMLVTE-VIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15401 237 --NPLKVAPKIPEWLFVLSyFMAYFNSCLNAVIYGVLNQNFRK 277
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
63-310 4.92e-11

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 62.36  E-value: 4.92e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHY-VRGHnWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVF 140
Cdd:cd15059  29 RKLRAPQNWFLVSLAVADILVgLLIMPFSLVNeLMGY-WYFGSVWCEIWLALDVLFCTASIVNLCAISLDRYWSVTQAVE 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  141 ALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYswrhfhTLRMTIFCLVLPLLVMAICYT 220
Cdd:cd15059 108 YNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPWHGAEPQCELSDDPGY------VLFSSIGSFYIPLLIMIIVYA 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  221 GIiktlLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHLDLVMLVTEVIAYSHCCMNPVI 300
Cdd:cd15059 182 RI----YRAAKRKERRFTLVLGVVMGAFVLCWLPFFFTYPLVVV--------CKTCGVPELLFKFFFWLGYCNSALNPVI 249
                       250
                ....*....|
gi 4502637  301 YAFVGERFRK 310
Cdd:cd15059 250 YTIFNKDFRR 259
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
63-310 6.42e-11

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 62.27  E-value: 6.42e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLFLVT--LPFWIHYVRGHNWVFGHGM----CKLLSGFYHTGLYSEIFFIILLTIDRYLAIV 136
Cdd:cd14978  28 KSMRSSTNVYLAALAVSDILVLLSalPLFLLPYIADYSSSFLSYFyayfLPYIYPLANTFQTASVWLTVALTVERYIAVC 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HAVFALRARTVTFGVITSIVTWGLAVLAALPEF------IFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLvL 210
Cdd:cd14978 108 HPLKARTWCTPRRARRVILIIIIFSLLLNLPRFfeyevvECENCNNNSYYYVIPTLLRQNETYLLKYYFWLYAIFVVL-L 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  211 PLLVMAICYTGIIKTL---------------LRCPSKKKYKAI-RLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCe 274
Cdd:cd14978 187 PFILLLILNILLIRALrkskkrrrllrrrrrLLSRSQRRERRTtIMLIAVVIVFLICNLPAGILNILEAIFGESFLSPI- 265
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4502637  275 rskhLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd14978 266 ----YQLLGDISNLLVVLNSAVNFIIYCLFSSKFRR 297
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
40-266 6.61e-11

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 62.15  E-value: 6.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFyhTGLYS 119
Cdd:cd15166   6 FYSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDEWPFGDYFCRILGAL--TVFYP 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  120 EI--FFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPeFIFYETEELFEETLCSALYPEDTVYsWRH 197
Cdd:cd15166  84 SIalWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFP-LLFLYEDPDKASNFTTCLKMLDIIH-LKE 161
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4502637  198 FHTLRMT--IFCLVLPLLVMAICYTGIIKTLLRCPSKK-----KYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQS 266
Cdd:cd15166 162 VNVLNFTrlIFFFLIPLFIMIGCYLVIIHNLVHGRTSKlkpkvKEKSIRIIITLIVQVLVCFVPFHICFAFLMLQN 237
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
41-312 7.97e-11

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 62.16  E-value: 7.97e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   41 YSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:cd15396   7 YSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVcVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVSV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  120 EIFFIILLTIDRYLAIVHAV-FALRARTVTFGVitsIVTWGLAVLAALPEFIFYETE------------ELFEETLCSAL 186
Cdd:cd15396  87 SIFSLVLIAIERYQLIVNPRgWKPSASHAYWGI---VLIWLFSLMISIPFLIFHQLTdepfrnlsshsdFYKDKVVCIEA 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  187 YPEDTVyswRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSK-----------KKYKAIRLIFV-IMAVFFIFWTP 254
Cdd:cd15396 164 WPSETE---RLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNSKidrmrenesrlSENKRINTMLIsIVVTFAACWLP 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4502637  255 YNV-AILLSSYQSILFgndcerSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15396 241 LNIfNVVFDWNHEVLM------SCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQKDL 293
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
71-312 1.19e-10

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 61.37  E-value: 1.19e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   71 IYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTF 149
Cdd:cd15150  36 IFLKNTVISDLLMILTFPFKIlSDAKLGSWPLRGFVCQVTSVIFYFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLG 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  150 GVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWrHFHTLRMTIFCLVLPLLVMAICYTGIIKTLL-- 227
Cdd:cd15150 116 AKILSTVIWASMFALSLPNMILTNRQPTPKNVKKCSLLKSEFGLVW-HEIVNYICQVIFWVNFLIVIVCYTLITKELYks 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  228 ----RCPSKKKYKAIRL-IFVIMAVFFIFWTPYNVAIL---LSSYQSILFgndCERSKHLDLVMLVTEVIAYSHCCMNPV 299
Cdd:cd15150 195 ykrtRGVGKVSRKKVNVkVFIIIAVFFICFVPFHFARIpytLSQTRDVFD---CTAKNTLFYVKESTLWLTSLNACLDPF 271
                       250
                ....*....|...
gi 4502637  300 IYAFVGERFRKYL 312
Cdd:cd15150 272 IYFFLCKSFRNSL 284
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
36-310 1.60e-10

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 61.29  E-value: 1.60e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15397   2 FLVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVcLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFAlrARTVTFGVITSIVTWGLAVLAALP--EFIFYETEELFEETLCSALYPEDTV 192
Cdd:cd15397  82 MSVTVSILSLVLIALERHQLIINPTGW--KPSVSQAYLAVVVIWMLACFISLPflAFHILTDEPYKNLSHFFAPLADKAV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  193 --YSW-----RHFHTLRMTIFCLVLPLLVMAICYTGIIKTL--------LRCPSKKKYKAIRLIFV----IMAVFFIFWT 253
Cdd:cd15397 160 ctESWpsehhKLAYTTWLLLFQYCLPLLFILVCYLRIYLRLrrrkdmleRRGEYNRRAGHSKRINVmlvsLVAAFALCWL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4502637  254 PYNV--AILLSSYQSILFgndCerskHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15397 240 PLNVfnAIADWNHEAIPH---C----QHNLIFSLCHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
63-310 2.75e-10

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 60.29  E-value: 2.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHavfA 141
Cdd:cd15326  29 RHLRIPTNYFIVNLAIADLLLSFTvLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRH---S 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTvtfgvitsIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTV---YSWRHFHTLRMTIFCLVLPLLVMAIC 218
Cdd:cd15326 106 LQYPT--------IVTRKRAILALLGVWVLSTVISIGPLLGWKEPAPPDDKvceITEEPFYALFSSLGSFYIPLIVILVM 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  219 YTGIIKTLLRCPSKKkyKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILfgndcersKHLDLVMLVTEVIAYSHCCMNP 298
Cdd:cd15326 178 YCRVYIVALKFSREK--KAAKTLGIVVGMFILCWLPFFIALPLGSLFSHL--------KPPETLFKIIFWLGYFNSCLNP 247
                       250
                ....*....|..
gi 4502637  299 VIYAFVGERFRK 310
Cdd:cd15326 248 IIYPCSSKEFKR 259
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
57-310 2.76e-10

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 60.37  E-value: 2.76e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYR---RLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRY 132
Cdd:cd17790  20 LVLISFKvnsELKTVNNYFLLSLACADLIIgAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNLLIISFDRY 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  133 LAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEdtvYSWRHFHTLRMTIFCLVLPL 212
Cdd:cd17790 100 FSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGERTVLAGQCYIQ---FLSQPIITFGTAIAAFYLPV 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  213 LVMAICYTGIIKTLLrcpskKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSyqsilFGNDCERSKHLDLVMLvtevIAYS 292
Cdd:cd17790 177 TIMIILYWRIYRETI-----KEKKAARTLSAILLAFILTWTPYNIMVLVST-----FCKDCVPKTLWELGYW----LCYV 242
                       250
                ....*....|....*...
gi 4502637  293 HCCMNPVIYAFVGERFRK 310
Cdd:cd17790 243 NSTVNPMCYALCNKSFRD 260
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
41-310 2.81e-10

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 60.67  E-value: 2.81e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   41 YSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLL---FLVTLPFWIHYVRGhnWVFGHGMCKLLSGFYHTGL 117
Cdd:cd15980   7 YLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLvgiFCMPTTLLDNIIAG--WPFGSTVCKMSGMVQGISV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  118 YSEIFFIILLTIDRYLAIVHAVfaLRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSW-- 195
Cdd:cd15980  85 SASVFTLVAIAVDRFRCIVYPF--KQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRVVLGSQNKTSPVYWcr 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 --------RHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCP---------------SKKKYKAIRLIFVIMAVFFIFW 252
Cdd:cd15980 163 edwpnqemRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAmphtgkhnqeqrhvvSRKKQKVIKMLLIVALLFILSW 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4502637  253 TPYNVAILLSSYQSIlfgNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15980 243 LPLWTLMMLSDYANL---SPNQLQIINIYIYPFAHWLAFFNSSVNPIIYGFFNENFRR 297
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
38-312 2.89e-10

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 60.18  E-value: 2.89e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   38 PPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTnIYLLNLAISDLLFLVTLPFWIHYVRG-HNWVFGHGMCKLLSGFYHTG 116
Cdd:cd15151   4 PVLYTVLFLVGLILNSVAAWIFFHIPSTSTFI-VYLKNTLVADLIMTLMLPFKILSDSGlGPWQLRAFVCRFSAVVFYIT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  117 LYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWR 196
Cdd:cd15151  83 MYISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKPATPISVKKCASLKSPLGLKWH 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  197 H-FHTLRMTIFCLVLPLlvMAICYTGIIKTLLRC-------PSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIL 268
Cdd:cd15151 163 EvVNYICQFIFWGVFAL--MVLFYTIISKKVYESykksrskDNKASKKTKAKVFIIVAVFFVCFAPFHFVRVPYTLSQTG 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4502637  269 FGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15151 241 KITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQRL 284
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
63-310 3.72e-10

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 59.93  E-value: 3.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15327  29 RHLQTVTNYFIVNLAIADLLLSTTvLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISVDRYVGVKHSLKY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSalYPEDTVYSwrhfhtLRMTIFCLVLPLLVMAICYTG 221
Cdd:cd15327 109 PTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPPPPDESICS--ITEEPGYA------LFSSLFSFYLPLMVILVMYFR 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  222 IIKTLLRCPSKKkyKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILfgndcersKHLDLVMLVTEVIAYSHCCMNPVIY 301
Cdd:cd15327 181 VYVVALKFSREK--KAAKTLAIVVGVFILCWFPFFFVLPLGSFFPAL--------KPSEMVFKVIFWLGYFNSCVNPIIY 250

                ....*....
gi 4502637  302 AFVGERFRK 310
Cdd:cd15327 251 PCSSKEFKR 259
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
41-310 3.82e-10

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 60.17  E-value: 3.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   41 YSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLL-FLVTLPFWIHYV-RGHNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd15358   7 YLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLvLLLGMPLELYEMwSNYPFLLGAGGCYFKTLLFETVCF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEfiFYETEELFEETLCSALYPED---TVYSW 195
Cdd:cd15358  87 ASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPN--TSLHGIFQLTVPCRGPVPDSatcMLVKP 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  196 RHFHTLRM---TIFCLVLPLLVMAICYTGI------IKTLLRCPSK------------------KKYKAIRLIFVIMAVF 248
Cdd:cd15358 165 RWMYNLIIqitTLLFFFLPMGTISVLYLLIglqlkrEKMLLVLEAKgskagdsyqhrriqqekrRRRQVTKMLFVLVVVF 244
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502637  249 FIFWTPYNVAILLssyQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15358 245 GICWAPFHTDRLM---WSFISQWTGELHLAFQYVHIISGVFFYLSSAANPVLYNLMSTRFRE 303
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
60-310 4.01e-10

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 59.70  E-value: 4.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   60 IKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHA 138
Cdd:cd15066  25 MRHRKLRVITNYFVVSLAMADMLVaLCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTASILHLCCISVDRYYAIVQP 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  139 VFALRARTVTFGVITSIVTWGLAVLAA-LPefifyeteelfeetLCSALY--PEDTVYSWRHFHTLRMT---IFCLV--- 209
Cdd:cd15066 105 LEYPSKMTKRRVAIMLANVWISPALISfLP--------------IFLGWYttEEHLQYRKTHPDQCEFVvnkIYALIsss 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  210 ----LPLLVMAICYTGIIKTllrcpSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSyqsiLFGNDCERSkhlDLVMLV 285
Cdd:cd15066 171 vsfwIPCIVMIFTYYRIYLE-----AKREHKAAKTLGIIMGAFILCWLPFFLWYVTTT----LCGDACPYP---PILVSI 238
                       250       260
                ....*....|....*....|....*
gi 4502637  286 TEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15066 239 LFWIGYFNSTLNPLIYAYFNRDFRE 263
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
63-310 5.74e-10

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 59.58  E-value: 5.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15307  29 RRLQNVTNYFLMSLAITDLMVAVlVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRF 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPeDTVYSwrhfhtLRMTIFCLVLPLLVMAICYTG 221
Cdd:cd15307 109 GRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHASVLVNGTCQIP-DPVYK------LVGSIVCFYIPLGVMLLTYCL 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  222 IIKTLLRCPSKK------KYKAIRLIFVIMAVFFIFWTPYNVAILLSSyqsilFGNDCERSKHLDLVMLVTeVIAYSHCC 295
Cdd:cd15307 182 TVRLLARQRSRHgriirlEQKATKVLGVVFFTFVILWSPFFVLNLLPT-----VCAECEERISHWVFDVVT-WLGYASSM 255
                       250
                ....*....|....*
gi 4502637  296 MNPVIYAFVGERFRK 310
Cdd:cd15307 256 VNPIFYTIFNKVFRQ 270
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
40-310 6.05e-10

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 59.71  E-value: 6.05e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd15208   6 LYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLViIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVF----ALRARTVTfgvitsIVTWGLAVLAALPEFIFYETEELFEETLCSAL----YPED 190
Cdd:cd15208  86 VSVLTLSCIALDRWYAICHPLMfkstAKRARVSI------LIIWIVSLLIMIPQAIVMECSRVVPLANKTILltvcDERW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  191 TVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLR--------CPSKK------------------KYKAIRLIFVI 244
Cdd:cd15208 160 SDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCrqipgtssVVQRKwnkprksavaaeekqlrsRRKTAKMLIVV 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4502637  245 MAVFFIFWTPYNVAILLsSYQSILFGNDCERSKHLdlvMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15208 240 VIMFAICYLPVHLLNIL-RYVFGLFTVDRETIYAW---FLFSHWLVYANSAINPIIYNFMSGKFRE 301
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-309 7.34e-10

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 59.10  E-value: 7.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   43 LVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLL-FLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEI 121
Cdd:cd15976   9 LVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLhIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  122 FFIILLTIDRYLAIvhavfALRARTVTFGV-----ITSIVTWGLAVLAALPEFIFYETEELFE---ETLCSALYPEDTVY 193
Cdd:cd15976  89 LSLCALSIDRYRAV-----ASWSRIKGIGVpkwtaVEIVLIWVVSIILAVPEAIGFDMITMDYkgeLLRICLLHPIQKTA 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWRHFHTLR---MTIFCLVLPLLVMAICYTGIIKTLLRCPS----------KKKYKAIRLIFVIMAVFFIFWTPYNVAIL 260
Cdd:cd15976 164 FMQFYKTAKdwwLFSFYFCLPLACTAVFYTLMTCEMLRKKNgmqialndhlKQRREVAKTVFCLVLVFALCWLPLHLSRI 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 4502637  261 LSsyQSILFGNDCERSKHLDLVMLVTEV---IAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15976 244 LK--LTIYDEKDPNRCELLSFFLVLDYIginMASLNSCINPIALYLVSKRFK 293
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
41-310 8.46e-10

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 59.07  E-value: 8.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   41 YSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLL---FLVTLPFWIHYVRGhnWVFGHGMCKLLSGFYHTGL 117
Cdd:cd15981   7 YLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLvgiFCMPTTLVDNLITG--WPFDNAMCKMSGLVQGMSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  118 YSEIFFIILLTIDRYLAIVHAVfaLRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYS--- 194
Cdd:cd15981  85 SASVFTLVAIAVERFRCIVHPF--RQKLTLRKAIVTIVIIWVLALIIMCPSAVTLTVTREEHHFMVDDYNNSYPLYScwe 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 -W-----RHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCP----------------SKKKYKAIRLIFVIMAVFFIFW 252
Cdd:cd15981 163 aWpdtemRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSapirgsqgeeeegrrvSKRKIKVINMLIIVALFFTLSW 242
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  253 TPYNVAILLSSYqsilfGNDCERSKHLDLVML--VTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15981 243 LPLWTLMLLTDY-----GHLSEDQLNLVTVYVfpFAHWLAFFNSSVNPIIYGYFNENFRR 297
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
58-312 1.01e-09

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 58.87  E-value: 1.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHN--WVFGHGMCKL---LSGFYhtGLYSeIFFIILLTIDRY 132
Cdd:cd15337  24 LFSKTKSLRTPSNMFIINLAISDFGFSAVNGFPLKTISSFNkkWIWGKVACELygfAGGIF--GFMS-ITTLAAISIDRY 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  133 LAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFI-FYETEELFEETLCSALY----PEDTVYSWrhfhtlRMTIFC 207
Cdd:cd15337 101 LVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFgWGRYVPEGFQTSCTFDYlsrdLNNRLFIL------GLFIFG 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  208 LVLPLLVMAICYTGIIK-----------TLLRCPSKKKYKA-------IRLI---FVIMAVFFIFWTPYNVAILLSsyqs 266
Cdd:cd15337 175 FLCPLLIIIFCYVNIIRavrnhekemtqTAKSGMGKDTEKNdarkkaeIRIAkvaIILISLFLLSWTPYAVVALLG---- 250
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4502637  267 iLFGNdcerskHLDLVMLVTEV---IAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15337 251 -QFGP------AYWITPYVSELpvmFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
60-310 1.17e-09

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 58.14  E-value: 1.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   60 IKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHA 138
Cdd:cd15061  25 ATTRRLRTITNCYIVSLATADLLVgVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCTASILNLCCISLDRYFAITYP 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  139 VFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSalYPEDTVYswRHFHTlrMTIFclVLPLLVMAIC 218
Cdd:cd15061 105 LKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCY--YTYDKGY--RIYSS--MGSF--FLPLLLMLFV 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  219 YTGIIktllrCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHLDLVMLVTeVIAYSHCCMNP 298
Cdd:cd15061 177 YLRIF-----RVIAKERKTAKTLAIVVGCFIVCWLPFFIMYLIEPF--------CDCQFSEALSTAFT-WLGYFNSVINP 242
                       250
                ....*....|..
gi 4502637  299 VIYAFVGERFRK 310
Cdd:cd15061 243 FIYAFYNKDFRR 254
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
41-309 1.26e-09

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 58.69  E-value: 1.26e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   41 YSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLL-FLVTLPFWIHYV-RGHNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd15133   7 YLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLvLLLGMPLELYELwQNYPFLLGSGGCYFKTFLFETVCL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAvfaLRART-VTFGVITSI--VTWGLAVLAALPEF----IFYETEELFEETLCSALYPEdt 191
Cdd:cd15133  87 ASILNVTALSVERYIAVVHP---LAARTcSTRPRVTRVlgCVWGVSMLCALPNTslhgIKFLGSGVPASAQCTVRKPQ-- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  192 vysWRHFHTLRMTIFCL-VLPLLVMAICYTGIIKTL---------------------LRCPSKKKYKAIRLIFVIMAVFF 249
Cdd:cd15133 162 ---AIYNMIPQHTGHLFfVLPMAVISVLYLLMALRLarergldatgagskigtrtgqLLQHPRTRAQVTKMLFILVVVFA 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502637  250 IFWTPYNVAILLSSYQSilfgnDCERSKHL--DLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15133 239 ICWAPFHIDRLMWSFIS-----DWTDNLHEvfQYVHIISGVFFYLSSAVNPILYNLMSTRFR 295
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
40-258 1.60e-09

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 58.21  E-value: 1.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTN-IYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLY 118
Cdd:cd14983   6 VYVLTILLGLPSNLLALYAFVNRARLRLTPNvIYMINLCLSDLVFILSLPIKIVEALSSAWTLPAVLCPLYNLAHFSTLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  119 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAV----LAALPEFIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd14983  86 ASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVIfhvtLVFILETSGGTLDINTPVGNSSTCYENFTPEQ 165
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502637  195 WRHFHTLRMTIfCLVL---PLLVMAICYTGIIKTLLR--CPSKKKYKAIRLIFVIMAVFFIFWTPYNVA 258
Cdd:cd14983 166 LALLAPVRLEL-SLVLfflPLAITAFCYVRCIRILVRsrLHERRKRRAVRVAVSTLLTFVVCFGPYNIS 233
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
36-304 1.67e-09

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 57.86  E-value: 1.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLL-FLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYH 114
Cdd:cd15398   2 FLIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILvVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  115 TGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYE-------TEELFEETLCSALY 187
Cdd:cd15398  82 VSVMVSTLMLMSIAIVRYHMIKHPLSNHLTANHGYFLLGTVWTLGFTICSPLPVFHKIVdlsetfnLESLKNKYLCIESW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  188 PEDtvySWRHFHTLRMTIFCLVLPLLVMAICYTGIiktllrCPSKKKYKAI--RLIFVIMaVFFIFWTPYNVAILLSSYQ 265
Cdd:cd15398 162 PSD---SYRIAFTISLLFVQYILPLVCLTVSHTSV------CRSVKRSRSVfyRLTIVIL-AFAVSWMPLHLFHLVTDFN 231
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4502637  266 SILFGNdcersKHLDLVMLVTEVIAYSHCCMNPVIYAFV 304
Cdd:cd15398 232 ANLISN-----RHFKLVYCICHLLGMLSCCLNPILYGFL 265
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
59-310 2.04e-09

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 57.94  E-value: 2.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd15400  25 VFRNRKLRNSGNVFVVSLALADLVVaLYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITGIAINRYCYICH 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYswrhfhTLRMTIFCLVLPLLVMAI 217
Cdd:cd15400 105 SFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEYDPRIYSCTFVQTASSSY------TIAVVVIHFIVPITVVSF 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  218 CYTGIIKTLLRCPSKKK-----------YKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGndcerSKHLDLVMLVT 286
Cdd:cd15400 179 CYLRIWVLVIQVRRKVKseskprlkpsdFRNFLTMFVVFVIFAICWAPLNLIGLAVAINPQEMA-----PKVPEWLFVVS 253
                       250       260
                ....*....|....*....|....
gi 4502637  287 EVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15400 254 YFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
61-312 2.32e-09

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 57.53  E-value: 2.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   61 KYRRLRIMTNIYLLNLAISDLLFL---VTLPFwIHYVRGhNWVFGHGMCkLLSGFYHT--GLYSeIFFIILLTIDRYLAI 135
Cdd:cd15078  27 KFKRLRTPTNLLLVNISLSDLLVSllgVTFTF-MSCVRG-RWVFDVAGC-VWDGFSNSlfGIVS-IMTLTVLAYERYIRV 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHAV---FALRARTVTFGVITSIvTWGLAVLAALPEFIFYETEELFEETLCSAlYPEDTVYswrhfhTLRMTIFCLVLPL 212
Cdd:cd15078 103 VHAKvvnFSWSWRAITYIWLYSL-AWTGAPLLGWNRYTLEVHGLGCSFDWKSK-DPNDTSF------VLLFFLGCLVVPL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  213 LVMAICYTGIIKT--LLRCPS-----------KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCerskhl 279
Cdd:cd15078 175 GIMAYCYGHILYEirMLRSVEdlqtfqvikilKYEKKVAKMCLLMISTFLICWMPYAVVSLLVTSGYSKLVTPT------ 248
                       250       260       270
                ....*....|....*....|....*....|...
gi 4502637  280 dlVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15078 249 --IAIIPSLFAKSSTAYNPVIYIFMIRKFRQCL 279
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
43-310 2.35e-09

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 57.61  E-value: 2.35e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   43 LVFTVGLLGNVVVVMILIKYR--RLRIMTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:cd15402   7 LIFTIVVDILGNLLVILSVYRnkKLRNAGNIFVVSLAVADLVVAIyPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  120 EIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYswrhfh 199
Cdd:cd15402  87 SIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSCTFAQSVSSAY------ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  200 TLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKK-----------YKAIRLIFVIMAVFFIFWTPYNVAILlssyqSIL 268
Cdd:cd15402 161 TIAVVFFHFILPIIIVTFCYLRIWILVIQVRRRVKpdnkpklkphdFRNFVTMFVVFVLFAVCWAPLNFIGL-----AVA 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4502637  269 FGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15402 236 VDPETIVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRR 277
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
58-308 7.90e-09

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 55.93  E-value: 7.90e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIH-YVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV 136
Cdd:cd15200  24 IFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDyYLRNEVWRFGATACQVNLFMLSMNRTASIVFLTAIALNRYLKVV 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HAVFALRARTVTFGVITSIVTWGLAVLAALPEFIfyeTEELFEETLCSALYPEDTVYSWRHFHTLrMTIFCLVLPLLVMA 216
Cdd:cd15200 104 HPHHQLSKASVGCAAKVAAGLWILILLLNIHLLL---LDHVQSNSTCLSYDHGTDPSASDRWHRI-LFFLEFFLPLGIIL 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  217 ICYTGIIKTLLR---CPSKKKYKAIRLIFVIMAVFFIFWTPynvAILLSSYQSILFG-NDCERSKHLDLVMLVTEVIAYS 292
Cdd:cd15200 180 FCIFSIILTLKQrklAKQAGPQRAVKVLAVIVLVYTVCFLP---SILFALASLVAFKvSQCRSLDLCTQLFHGSLAFTYL 256
                       250
                ....*....|....*.
gi 4502637  293 HCCMNPVIYAFVGERF 308
Cdd:cd15200 257 NSALDPVLYCFSSPSF 272
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
63-309 8.27e-09

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 55.80  E-value: 8.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15051  29 RRLRNLTNYFIVSLAVTDLLLgLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASILNLFAISLDRYLAITAPLRY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LR---ARTVtFGVITSIVTWGLAVlAALPEFIFYETEELFEETLCSalyPEDTVYSWRHFHTLRMTIFCLVLPLLVMAIC 218
Cdd:cd15051 109 PSrvtPRRV-AIALAAIWVVSLAV-SFLPIHLGWNTPDGRVQNGDT---PNQCRFELNPPYVLLVAIGTFYLPLLIMCGV 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  219 YTGI----------IKTLLRCP---------SKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFgndcerSKHL 279
Cdd:cd15051 184 YLRIfriareqakrINALTPAStanssksaaTAREHKATVTLAAVLGAFIICWFPYFTYFTYRGLCGDNI------NETA 257
                       250       260       270
                ....*....|....*....|....*....|
gi 4502637  280 DLVMLvteVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15051 258 LSVVL---WLGYANSALNPILYAFLNRDFR 284
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
63-309 1.96e-08

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 54.57  E-value: 1.96e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15299  32 KQLKTVNNYFLLSLACADLIIgVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTY 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEdtvYSWRHFHTLRMTIFCLVLPLLVMAICYTG 221
Cdd:cd15299 112 RAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPDECFIQ---FLSEPIITFGTAIAAFYLPVTIMTILYWR 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  222 IIKTLLrcpskKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSyqsilFGNDCERskhlDLVMLVTEVIAYSHCCMNPVIY 301
Cdd:cd15299 189 IYKETI-----KEKKAAQTLSAILLAFIITWTPYNIMVLVNT-----FCDSCIP----KTYWNLGYWLCYINSTVNPVCY 254

                ....*...
gi 4502637  302 AFVGERFR 309
Cdd:cd15299 255 ALCNKTFR 262
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
63-310 2.17e-08

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 54.45  E-value: 2.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15295  29 KNLRHRSNYFFLNLAISDFFVgAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLISYDRYQSVSNAVSY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIV-TWGLAVLAALPeFIFYETEELFEETLCSALYpedtvYSWRHFhTLRMTIFCLVLPLLVMAICYT 220
Cdd:cd15295 109 RNQQTATLRIVTQMVaVWVLAFLVHGP-AILVSDSWKTEDGECEPEF-----FSNWYI-LAITSVLEFLVPVILVAYFNT 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  221 GIIKTLLRcpSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHlDLVMLVTEVIAYSHCCMNPVI 300
Cdd:cd15295 182 QIYWSLWK--RLRDRKLAKSLAIILGTFAICWAPYSLFTIIRAA--------CEKHRG-SPWYNFAFWLQWFNSFINPFL 250
                       250
                ....*....|
gi 4502637  301 YAFVGERFRK 310
Cdd:cd15295 251 YPLCHKRFRK 260
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
57-310 2.52e-08

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 54.36  E-value: 2.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLsGFYHT--GLYSEIFFIIlLTIDRYL 133
Cdd:cd15086  23 VLFCKYKVLRSPINLLLLNISLSDLLVCVLgTPFSFAASTQGRWLIGEHGCRWY-GFANSlfGIVSLISLAV-LSYERYC 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  134 AIVHAVFALRA--RTVTFGVITSivtWGLAVLAALPEFI-FYETEELFEETLCSALYPEDTVYSWRHFHTLrmTIFCLVL 210
Cdd:cd15086 101 TLLRPTEADVSdyRKAWLGVGGS---WLYSLLWTLPPLLgWSSYGPEGPGTTCSVQWTSRSANSISYIICL--FIFCLLL 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  211 PLLVMAICYTGIIKTLLRC------PSKKKYKAIRLIFVIMAVFFIF-WTPYNVAILLSSyqsilFGNdcerskhLDLVM 283
Cdd:cd15086 176 PFLVMVYCYGRLLYAIKQVgkinksTARKREQHVLLMVVTMVICYLLcWLPYGVMALLAT-----FGK-------PGLVT 243
                       250       260       270
                ....*....|....*....|....*....|.
gi 4502637  284 LVTEVI----AYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15086 244 PVASIVpsilAKSSTVVNPIIYVFMNKQFYR 274
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
57-310 3.29e-08

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 53.82  E-value: 3.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRR-LRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLA 134
Cdd:cd15297  22 MVSIKVNRhLQTVNNYFLFSLACADLIIgVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFC 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  135 IVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTlrmTIFCLVLPLLV 214
Cdd:cd15297 102 VTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRTVPEGECYIQFFSNAAVTFGT---AIAAFYLPVII 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  215 MAICYTGIIKTllrcpSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDcerskhldlVMLVTEVIAYSHC 294
Cdd:cd15297 179 MTVLYWQISRA-----SSREKKVTRTILAILLAFIITWTPYNVMVLINTFCASCIPNT---------VWTIGYWLCYINS 244
                       250
                ....*....|....*.
gi 4502637  295 CMNPVIYAFVGERFRK 310
Cdd:cd15297 245 TINPACYALCNATFKK 260
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
43-311 3.60e-08

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 54.06  E-value: 3.60e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   43 LVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGH-----GMCKLLSGFYHTG 116
Cdd:cd15128   9 LIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIdLPINVYKLLAMDWPFGDqpfgqFLCKLVPFIQKAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  117 LYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPE---FIFYETEELFEETLCSALYPEDTVY 193
Cdd:cd15128  89 VGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEaigFDMVRFNYKGVTLRTCLLRPETSFM 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 S-WRHFHTLRMTIFCLVLPLLVMAICYT-----------GIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILL 261
Cdd:cd15128 169 KfYIDVKDWWLFGFYFCLPLVCTAIFYTlmtcemlrkrnGMLRIALNEHLKQRREVAKTVFCLVVIFALCWLPLHLSRIL 248
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4502637  262 SsyQSILFGNDCERSKHLDLVMLVTEV---IAYSHCCMNPVIYAFVGERFRKY 311
Cdd:cd15128 249 K--LTVYDQNDPNRCELLSFLLVLDYFginLATLNSCINPIALYFVSRKFKNC 299
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
63-310 4.02e-08

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 53.89  E-value: 4.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15065  28 RRLRKKSNLFIVSLAVADLLVaLLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASILNLCAISLDRYIHIKKPLKY 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGL-AVLAALPEFIFYETEELFEETLCS-ALYPEDTVYSWRHF-HTLRMTIFCLVLPLLVMAIC 218
Cdd:cd15065 108 ERWMTTRRALVVIASVWILsALISFLPIHLGWHRLSQDEIKGLNhASNPKPSCALDLNPtYAVVSSLISFYIPCLVMLLI 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  219 YTGI----------IKTLLRCPSKKK------------------YKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFG 270
Cdd:cd15065 188 YSRLylyarkhvvnIKSQKLPSESGSkfqvpslsskhnnqgvsdHKAAVTLGIIMGVFLICWLPFFIINIIAAFCKTCIP 267
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4502637  271 NDCerskhldlvMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15065 268 PKC---------FKILTWLGYFNSCLNPIIYSIFNSEFRR 298
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
40-170 4.50e-08

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 53.64  E-value: 4.50e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRImTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYS 119
Cdd:cd14994   7 LYSVVLIGGVIGVILMSFLLVKMNTRSV-TTTAVINLIVVHSLFLLTVPFRIYYYASKTWKFGMPLCKMVSAMIHIHMHL 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 4502637  120 EIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFI 170
Cdd:cd14994  86 TFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVPVFV 136
7tmA_ACKR1_DARC cd15010
Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G ...
73-307 4.58e-08

Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G protein-coupled receptors; Atypical chemokine receptor 1 (ACKR1), also known as DARC (Duffy antigen receptor for chemokines) or Fy glycoprotein (GpFy), was originally identified on erythrocytes. ACKR1 is also ubiquitously expressed by endothelial cells of venules and is highly promiscuous among all chemokine receptor. It binds many proinflammatory chemokines from both the CC and CXC subfamilies, including CCL2, CCL5, CCL7, CCL11, CXCL1, CXCL2, CXCL3, and CXCL5. Erythrocyte ACKR1 is thought to act as a chemokine sink, limiting the levels of circulating chemokines, thereby controlling leukocyte activation. ACKR1-deficient erythrocytes are shown to confer resistance to the malarial parasite, Plasmodium vivax. On the other hand, ACKR1-expressing endothelial cells can internalize chemokines. ACKR1-internalized chemokines can be moved intact across the endothelium and promotes neutrophil transmigration. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 410631  Cd Length: 257  Bit Score: 53.64  E-value: 4.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   73 LLNLAISDLLFLVTLPFwihYVRGHNWVFGHGMCKLLSGFYHTGLYSEIffiilLTIDRYLAIVHAVFALRARTVTFGVi 152
Cdd:cd15010  40 LAQLAVGSALFSIVVPI---LAPGLSQGWGTGLCKLAYLVWYGSAFAQA-----LLVGCHACLGPWLGWGQVPGLTLGL- 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  153 tSIVTWGLAVLAALPefifYETEELFEETLCSALYPEDtVYSWRHFH-TLRMTIFCLvLPLLVMAicyTGIIKTLLRcps 231
Cdd:cd15010 111 -AVGLWGAAALLALP----VALASGTSGGPCTLRSSRD-LEALYLTHlAACLAIFVL-LPLGLLG---AKGLKTALR--- 177
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502637  232 kkkyKAIRLIFVIMAVFFIFWTPYNVAILLSS--YQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGER 307
Cdd:cd15010 178 ----VGPGPWVGVLWLWFIFWWPYGVVLGLDFlvRSKLLLLSTCGAQEALDYMLGLSEALGILHCVATPLLLALVCHQ 251
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
64-310 4.73e-08

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 53.49  E-value: 4.73e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   64 RLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFAL 142
Cdd:cd15300  30 QLKTVNNYYLLSLACADLIIgIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYR 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  143 RARTVTFGVITSIVTWGLAVLAALPEFI---FYETEELFEETLCSALYPEDTVYswrhfhTLRMTIFCLVLPLLVMAICY 219
Cdd:cd15300 110 AKRTPKRAGIMIGLAWLISFILWAPPILcwqYFVGKRTVPERECQIQFLSEPTI------TFGTAIAAFYIPVSVMTILY 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  220 TGIIKTLLrcpskKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHLDLVMLvTEVIAYSHCCMNPV 299
Cdd:cd15300 184 CRIYKETI-----KERKAAQTLSAILLAFIITWTPYNIMVLVSTF--------CSDCIPLTLWHL-GYWLCYVNSTVNPM 249
                       250
                ....*....|.
gi 4502637  300 IYAFVGERFRK 310
Cdd:cd15300 250 CYALCNKTFRK 260
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
57-259 5.13e-08

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 53.40  E-value: 5.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd15214  22 VTLYKKSYLLTLSNKFVFSLTLSNLLLsVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAIDRYYAV 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHAVFALRARTVTFGVITSIVTWGLAVLAALPE-FIFYETEELFEETLCSALYPEDTVYswrhfhTLRMTIFCLVLPLLV 214
Cdd:cd15214 102 LYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPlFGWSSLEFDRFKWMCVAAWHKEAGY------TAFWQVWCALLPFVV 175
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 4502637  215 MAICYTGIiktlLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAI 259
Cdd:cd15214 176 MLVCYGFI----FRVARANQCKAFITILVVLGAFVTTWGPYMVVI 216
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
40-310 5.18e-08

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 53.43  E-value: 5.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHY--VRGHNWVFGHGMCKLLSGFYHTGL 117
Cdd:cd15310   6 SYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYleVTGGVWNFSRICCDVFVTLDVMMC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  118 YSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSI---VTWGLAVLAALPefIFYETEELFEETLCSALYPEDTVYS 194
Cdd:cd15310  86 TASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVSLmitAVWVLAFAVSCP--LLFGFNTTGDPTVCSISNPDFVIYS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 wrhfhtlrmTIFCLVLPLLVMAICYTGIIKTLLRcpskkKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCE 274
Cdd:cd15310 164 ---------SVVSFYLPFGVTLLVYVRIYVVLLR-----EKKATQMLAIVLGAFIVCWLPFFLTHILNTH--------CQ 221
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4502637  275 RSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15310 222 ACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRR 257
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
62-310 6.70e-08

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 53.01  E-value: 6.70e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   62 YRRLRIMTNIYLLNLAISDLL--FLVTLPFWIHYVRgHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAv 139
Cdd:cd15314  28 FKQLHTPTNYLILSLAVADLLvgGLVMPPSMVRSVE-TCWYFGDLFCKIHSSFDITLCTASILNLCFISIDRYYAVCQP- 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  140 FALRARTVTFGVITSI-VTWGLAVLAALPefIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAIC 218
Cdd:cd15314 106 LLYRSKITVRVVLVMIlISWSVSALVGFG--IIFLELNIKGIYYNHVACEGGCLVFFSKVSSVVGSVFSFYIPAVIMLCI 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  219 YTGI--------------IKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndcerSKHLDLVML 284
Cdd:cd15314 184 YLKIflvaqrqarsiqsaRTKSGASSSKMERKATKTLAIVMGVFLLCWTPFFLCNIIDPF-----------INYSIPPVL 252
                       250       260
                ....*....|....*....|....*....
gi 4502637  285 VtEV---IAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15314 253 I-EVlnwLGYSNSTLNPFIYAFFYSWFRK 280
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
40-303 7.61e-08

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 53.24  E-value: 7.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLL--FLVTLP--FWIHYVRGHNWVFghgMCKLLSGFYHT 115
Cdd:cd15388   6 VLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVvaFFQVLPqlVWDITDRFRGPDV---LCRLVKYLQVV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGvITSIVTWGLAVLAALPE-FIFYETEELFEETLCSALYPEdtvyS 194
Cdd:cd15388  83 GMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWN-GPVCVAWAISLILSLPQvFIFSKVEVAPGVYECWACFIE----P 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  195 W-RHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLR---------------------------CPSKKKYKAIRLIFVIMA 246
Cdd:cd15388 158 WgLKAYVTWITLVVFVLPTLIITVCQVLIFKEIHIniylksqiivavvkkkqllssrassvaEVSKAMIKTVKMTLVIVL 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4502637  247 VFFIFWTPYNVAILLSSYQSilfGNDCERSKHLDLVMLvteviAYSHCCMNPVIYAF 303
Cdd:cd15388 238 VYVLCWAPFFLVQLWSVWDP---KAPTEGATFTILMLL-----ASLNSCTNPWIYMA 286
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
63-310 1.33e-07

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 52.33  E-value: 1.33e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15298  29 RQLQTVNNYFLFSLACADLIIGAfSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTlrmTIFCLVLPLLVMAICYTG 221
Cdd:cd15298 109 PARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGT---AIAAFYLPVVIMTVLYIH 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  222 IiktllRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCErSKHLDLVMLVTEVIAYSHCCMNPVIY 301
Cdd:cd15298 186 I-----SLASARERKVTRTIFAILLAFILTWTPYNVMVLVNTF--------CQ-SCIPDTVWSIGYWLCYVNSTINPACY 251

                ....*....
gi 4502637  302 AFVGERFRK 310
Cdd:cd15298 252 ALCNATFKK 260
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
61-301 1.46e-07

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 52.45  E-value: 1.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   61 KYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV--- 136
Cdd:cd15058  27 RTSRLQTMTNIFITSLACADLVMgLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITrpl 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 -HAVFALRARTVTFGVITSIVTwglAVLAALPEFIFYETEELFEETLCSAlYPEDTVYSWRHFHTLRMTIFCLVLPLLVM 215
Cdd:cd15058 107 rYQVLLTKRRARVIVCVVWIVS---ALVSFVPIMNQWWRANDPEANDCYQ-DPTCCDFRTNMAYAIASSVVSFYIPLLIM 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  216 AICYTG-----------IIKTLLRCPS-------------------------KKKYKAIRLIFVIMAVFFIFWTPYNVAI 259
Cdd:cd15058 183 IFVYARvfliatrqlqlIDKRRLRFQSecpapqttspegkrssgrrpsrltvVKEHKALKTLGIIMGTFTLCWLPFFIAN 262
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4502637  260 LLSSyqsilFGNDCERskhlDLVMLVTEVIAYSHCCMNPVIY 301
Cdd:cd15058 263 IINV-----FNRNLPP----GEVFLLLNWLGYINSGLNPIIY 295
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
57-312 1.79e-07

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 52.11  E-value: 1.79e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVF-GHGMCkLLSGFYHT-----GLYSeiffIILLTID 130
Cdd:cd15082  36 LVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFlGVWAC-VLEGFAVTffgivALWS----LAVLAFE 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  131 RYLAIVHAV--FALRARTVTFGVitsIVTWGLAVLAALPEFIFYETEELFEETLCSalypEDTVYSWR-HFHTLRMTIF- 206
Cdd:cd15082 111 RFFVICRPLgnIRLQGKHAALGL---LFVWTFSFIWTIPPVLGWSSYTVSKIGTTC----EPNWYSGNmHDHTYIITFFt 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  207 -CLVLPLLVMAICYTGIIKTL---------LRCPSKKKYKAIRLIFVIMAVFFIFWTPYNV-AILLSSYQSIlfgndcer 275
Cdd:cd15082 184 tCFILPLGVIFVSYGKLLQKLrkvsntqgrLGNARKPERQVTRMVVVMIVAFMVCWTPYAAfSILVTAHPTI-------- 255
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4502637  276 skHLD-LVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15082 256 --HLDpRLAAIPAFFSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
71-320 2.62e-07

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 51.49  E-value: 2.62e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   71 IYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFG 150
Cdd:cd14973  36 VYILNLAAADFLFLSCQAIQSLEDLLGGSLPGFALCRLLATLMFFSYTVGLSLLAAISTERCLSVLFPIWYRCHRPKHLS 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  151 VITSIVTWGLAVLAALPEFIfyeteelfeetLCSALYPEDTVYSWRHFHTLRMTIFclVLPLLVMAICYTGIIKTLLRCP 230
Cdd:cd14973 116 AVVCALLWALSLLLSVLESY-----------FCGFLFWKFNESACRTFNFLSALLF--LLLFLVMCVSSLTLLIRVQCSS 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  231 skKKYKAIRLIFVIMA---VFFIFWTPYNVAILLSSYQSilfgndcerSKHLDLVMLVTEVIAYSHCCMNPVIYAFVG-- 305
Cdd:cd14973 183 --QRRPPTRLYVVILLtvlVFLLCGLPLGIYWFLLLWFS---------NYLFHTFHPISDLLSCVNSSANPIIYFFVGsl 251
                       250
                ....*....|....*..
gi 4502637  306 --ERFRKYLRHFFHRHL 320
Cdd:cd14973 252 rgRRLREPLRVVLQRAL 268
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
63-309 2.63e-07

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 51.34  E-value: 2.63e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAV-- 139
Cdd:cd15063  29 RKLRTVTNLFIVSLACADLLVgTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAISLDRYLAITRPIry 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  140 ----FALRARTVTFGVitsivtWGLAVLAALPEFIFYE-TEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLV 214
Cdd:cd15063 109 pslmSTKRAKCLIAGV------WVLSFVICFPPLVGWNdGKDGIMDYSGSSSLPCTCELTNGRGYVIYSALGSFYIPMLV 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  215 MAICYTGIIKTllrcpSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSyqsilFGNDCERskhlDLVMLVTEVIAYSHC 294
Cdd:cd15063 183 MLFFYFRIYRA-----ARMETKAAKTVAIIVGCFIFCWLPFFTVYLVRA-----FCEDCIP----PLLFSVFFWLGYCNS 248
                       250
                ....*....|....*
gi 4502637  295 CMNPVIYAFVGERFR 309
Cdd:cd15063 249 ALNPCIYALFSRDFR 263
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
63-310 2.96e-07

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 50.95  E-value: 2.96e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15062  29 RHLRTPTHYFIVNLAVADLLLSFTvLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCVISVDRYIGVRYPLNY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSAlypedtvySWRHFHTLRMTIFCLVLPLLVMAICYTG 221
Cdd:cd15062 109 PTIVTARRATVALLIVWVLSLVISIGPLLGWKEPAPADEQACGV--------NEEPGYVLFSSLGSFYLPLAIILVMYCR 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  222 IIKTLLRCPSKKkyKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHLDLVMLVTEVIAYSHCCMNPVIY 301
Cdd:cd15062 181 VYVVAFKFSREK--KAAKTLGIVVGAFVLCWFPFFVVLPLGSL--------FSTLKPPEPVFKVVFWLGYFNSCLNPIIY 250

                ....*....
gi 4502637  302 AFVGERFRK 310
Cdd:cd15062 251 PCSSREFKR 259
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
37-312 3.01e-07

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 51.34  E-value: 3.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFW-IHYVRGHNWVFGHGMCKLLSGFYHT 115
Cdd:cd14996   3 LPIIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQaAYFLKGFYWKYQSTQCRIANFFGTL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  116 GLYSEIFFIILL--------------------TIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPeFIFYETE 175
Cdd:cd14996  83 VIHVSMCVSILIlswiaisryatlmkhdsatqKQSCYEKIFYGHFLKRFRQPKFARYLCIYIWGVVLCIIIP-VVVYYSV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  176 ELFEETLCSALYPEDTVYSWRHFHTL-RMTIFCLVLPLLVMAICYTGIIKTLLR-----CPSKKKY---KAIRLIFVIMA 246
Cdd:cd14996 162 READEDGESLCYNRQVELGAKGSQIAgLIATTFFFLFFLVVLLSYYSFVNHLRRiqkntCISEKDLiyrSVKRNILIIQA 241
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  247 VFFIFWTPYNVaillssYQSILFG----NDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd14996 242 LLVVCFLPYHI------FKPVFYVlhqrEDCQQLNYLIETKNILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
62-310 3.09e-07

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 51.05  E-value: 3.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   62 YRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVF 140
Cdd:cd15325  28 HRHLQTVTHYFIVNLAVADLLLTSTvLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISIDRYIGVSYPLR 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  141 ALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSalYPEDTVYSwrhfhtLRMTIFCLVLPLLVMAICYT 220
Cdd:cd15325 108 YPSIMTERRGLLALLCVWVLSLVISIGPLFGWKEPAPEDETICQ--ITEEPGYA------LFSALGSFYLPLAIILVMYC 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  221 GIIKTLLRCPSKKkyKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILfgndcersKHLDLVMLVTEVIAYSHCCMNPVI 300
Cdd:cd15325 180 RVYVVALKFSREK--KAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAY--------KPSDTVFKITFWLGYFNSCINPII 249
                       250
                ....*....|
gi 4502637  301 YAFVGERFRK 310
Cdd:cd15325 250 YPCSSQEFKK 259
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
71-309 3.97e-07

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 50.56  E-value: 3.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   71 IYLLNLAISDLLFLVTLPFWI-HYVRGHNWVFghgmCKLLSGF-YHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVT 148
Cdd:cd15163  37 IYTINLVVTDLLVGLSLPTRIvMYYSAGNCLT----CSFVHIFsYFVNMYCSILFLTCICVDRYLAIVQVEASRRWRNPN 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  149 FGVITSIVTWGLAVLAALpefifyeteelfeetlcSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAIcYTGIIKTLLR 228
Cdd:cd15163 113 YAKGICVFIWLFAIVVTF-----------------SILTTAIKFASCCLSKLFALTVFEFFLPLLIITF-FTIRIMCALS 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  229 CPS------KKKYKAIRLIFVIMAVFFIFWTPYNVAILLssyqsILFGNDCERSKHLdLVMLVTEVIAYSHCCMNPVIYA 302
Cdd:cd15163 175 RPGlmhqsrERRMRAVQLLITVLIIFMICFTPFHVRQVA-----VAFNPDIPHHTSL-IVYHVTVTLSSLNSCMDPIVYC 248

                ....*..
gi 4502637  303 FVGERFR 309
Cdd:cd15163 249 FVTNNFQ 255
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
63-261 5.20e-07

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 50.56  E-value: 5.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15296  29 SSLRTQGNFFFLNLAISDFLVgGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDYLLCTASVFNIVLISYDRFLSVTRAVSY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVT-FGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEdTVYSWrhFHTLRMTIFCLVLPLLVMAI--- 217
Cdd:cd15296 109 RAQKGMTrQAVLKMVLVWVLAFLLYGPAIISWEYIAGGSIIPEGECYAE-FFYNW--YFLMTASTLEFFTPFISVTYfnl 185
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 4502637  218 -CYTGIIKTLLRCPSKKkyKAIRLIFVIMAVFFIFWTPYNVAILL 261
Cdd:cd15296 186 sIYLNIQKRRFRLSRDK--KVAKSLAIIVCVFGLCWAPYTLLMII 228
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
72-167 5.52e-07

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 50.53  E-value: 5.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   72 YLLNLAISDLL-FLVTLPFWIHYVR-GHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTF 149
Cdd:cd15005  38 FLLDLCLADGLrSLACFPFVMASVRhGSGWIYGALSCKVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWT 117
                        90
                ....*....|....*...
gi 4502637  150 GVITSIVTWGLAVLAALP 167
Cdd:cd15005 118 CLAVICMAWTLSVAMAFP 135
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-309 5.74e-07

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 50.29  E-value: 5.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   43 LVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEI 121
Cdd:cd15977   9 VIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYiLIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  122 FFIILLTIDRYLAIvhavfALRARTVTFGV-----ITSIVTWGLAVLAALPE---FIFYETEELFEETLCSALYPEDTVY 193
Cdd:cd15977  89 LSLCALSIDRYRAV-----ASWSRIRGIGIpvwkaVEVTLIWAVAIIVAVPEaiaFDMVEIDYRGQTLLVCMLPMEQTSS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  194 SWRHFHTLR---MTIFCLVLPLLVmaicyTGIIKTLLRCPSKKKYKAIRL---------------IFVIMAVFFIFWTPY 255
Cdd:cd15977 164 FMRFYQDVKdwwLFGFYFCLPLAC-----TGVFYTLMSCEMLSIKNGMRIalndhmkqrrevaktVFCLVVIFALCWLPL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4502637  256 NVAILLSsyQSILFGNDCERSKHLDLVMLVTEV---IAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15977 239 HLSRILK--KTIYDVKDPQRCELLSFLLVMDYTginMASLNSCINPVALYFVSRKFK 293
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-310 5.93e-07

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 50.33  E-value: 5.93e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   36 FVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNI---YLLNLAISDLL-FLVTLP------FWIHyvrgHNWVFGHGM 105
Cdd:cd15130   2 LVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTvryHLGSLALSDLLiLLLAMPvelynfIWVH----HPWAFGDAG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  106 CKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA--LRARTVTFGVITSIvtWGLAVLAALPEFIFYETEELFE---- 179
Cdd:cd15130  78 CRGYYFLRDACTYATALNVASLSVERYLAICHPFKAktLMSRSRTKKFISAI--WLASALLAIPMLFTMGLQNESDdgth 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  180 --ETLCSALYPEDTVYSWRHFHTLrmtiFCLVLPLLVMAICYTGIIKTLLRCPSKkkykAIRLIFVIMAVFFIFWTPYNV 257
Cdd:cd15130 156 pgGLVCTPIVDTATLKVVIQVNTF----MSFLFPMLVTSILNTVIANKLVQALRR----GVLVLRAVVIAFVVCWLPYHV 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4502637  258 AILLSSYQSILFGNDCERSKHLDLVMlVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15130 228 RRLMFCYISDEQWTTFLFDFYHYFYM-LTNALFYVSSAINPILYNLVSANFRQ 279
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
63-261 9.66e-07

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 49.54  E-value: 9.66e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15335  29 KKLHQPANYLICSLAVTDFLVaVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEelfeetlcSALYPEDTVYSWRHF-HTLRMTIFCLVLPLLVMAICYT 220
Cdd:cd15335 109 ARKRTAKRAGLMILTVWTISIFISIPPLFWRNHH--------DANIPSQCIIQHDHViYTIYSTFGAFYIPLTLILILYY 180
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 4502637  221 GIIKTLLRcpskkKYKAIRLIFVIMAVFFIFWTPYNVAILL 261
Cdd:cd15335 181 RIYHAASR-----ERKAARILGLILGAFILSWLPFFIKELI 216
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
58-309 9.88e-07

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 49.45  E-value: 9.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNW-VFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV 136
Cdd:cd15080  24 VTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYfVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVC 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HAVFALRARTvTFGVITSIVTWGLAVLAALPEFI-FYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVM 215
Cdd:cd15080 104 KPMSNFRFGE-NHAIMGVAFTWVMALACAAPPLVgWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPLIVI 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  216 AICYTGIIKTLLRCPSKKKYKA---------IRLIFVIMAVFFIFWTPY-NVAILLSSYQSILFGndcerskhlDLVMLV 285
Cdd:cd15080 183 FFCYGRLVCTVKEAAAQQQESAttqkaekevTRMVIIMVIAFLICWVPYaSVAFYIFTHQGSDFG---------PIFMTI 253
                       250       260
                ....*....|....*....|....
gi 4502637  286 TEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15080 254 PAFFAKSSAVYNPVIYILMNKQFR 277
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
65-266 1.35e-06

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 49.07  E-value: 1.35e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   65 LRIMTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALR 143
Cdd:cd15404  31 MRSAINILLASLAFADMMLAVlNMPFALVTIITTRWIFGDAFCRVSAMFFWLFVMEGVAILLIISIDRFLIIVQKQDKLN 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  144 ARTVTfgvITSIVTWGLAVLAALPEFI-FYETEELFEETLCSALYPEDTVYswrHFHTLRMTIFCLVLPLLVMAICYTGI 222
Cdd:cd15404 111 PYRAK---VLIAVSWAVSFCVAFPLAVgSPDLQIPSRAPQCVFGYTTNPGY---QAYVILIMLIFFFIPFMVMLYSFMGI 184
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 4502637  223 IKTLlrcpSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQS 266
Cdd:cd15404 185 LNTV----RSFKTRAFTTILILFIVFTVCWAPFTTYSLVATFNS 224
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
57-312 1.50e-06

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 49.03  E-value: 1.50e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLLNLAISDLL--FLVTLPFWIHYVRGHnWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLA 134
Cdd:cd15054  23 LLIFTQRSLRNTSNYFLVSLFMSDLMvgLVVMPPAMLNALYGR-WVLARDFCPIWYAFDVMCCSASILNLCVISLDRYLL 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  135 IVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTvYSWRHFHTLRMTIF--CLVLPL 212
Cdd:cd15054 102 IISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELGHERTLPNLTSGTVE-GQCRLLVSLPYALVasCLTFFL 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  213 LVMAICYTgiIKTLLRcPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgNDCERSKHLDLVMLvtevIAYS 292
Cdd:cd15054 181 PSGAICFT--YCRILL-AARKALKASLTLGILLGMFFVTWLPFFVANVVQAV------CDCVSPGLFDVLTW----LGYC 247
                       250       260
                ....*....|....*....|
gi 4502637  293 HCCMNPVIYAFVGERFRKYL 312
Cdd:cd15054 248 NSTMNPIIYPLFMRDFKRAL 267
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
59-310 2.38e-06

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 48.80  E-value: 2.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRI-MTNIYLLNLAISDLLFLVTLPFW--IHYVRGHnWVFGhGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd15319  25 VVRFRHLRSkVTNIFIVSLAVSDLFVALLVMPWkaVAEVAGY-WPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAI 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHAVFALRARTVTFGVITSIVTWGLAVLAAlpeFI---------FYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIF 206
Cdd:cd15319 103 SSPFRYERKMTQRVALVMISVAWTLSVLIS---FIpvqlnwhkdSGDDWVGLHNSSISRQVEENCDSSLNRTYAISSSLI 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  207 CLVLPLLVMAICYTGIIK--------------------------------TLLRCPSKKKYKAIRLIFVIMAVFFIFWTP 254
Cdd:cd15319 180 SFYIPVAIMIVTYTRIYRiaqiqirrissleraaehaqscrsnridchhhTSLRTSIKKETKVLKTLSVIMGVFVCCWLP 259
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  255 YnvaILLSSYQSILFGNDCERSKHLDLVMLVTEVI----AYSHCCMNPVIYAFVGErFRK 310
Cdd:cd15319 260 F---FILNCMVPFCDRPPADPDAGLPCVSETTFDVfvwfGWANSSLNPIIYAFNAD-FRK 315
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
59-310 2.64e-06

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 48.25  E-value: 2.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd15056  25 VCTDRQLRKKTNYFVVSLAVADLLVaVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASIMHLCCIALDRYYAICC 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCS-ALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMA 216
Cdd:cd15056 105 QPLVYKMTPLRVAVMLGGCWVIPTFISFLPIMQGWNHIGIEDLIAFNcASGSTSCVFMVNKPFAIICSTVAFYIPALLMV 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  217 ICYTGI----------IKTLLRCPSKKKY-------------KAIRLIFVIMAVFFIFWTPYNVAILLSSYQSilfgndc 273
Cdd:cd15056 185 LAYYRIyvaareqahqIRSLQRAGSSNHEadqhrnsrmrtetKAAKTLGIIMGCFCVCWAPFFVTNIVDPFIG------- 257
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4502637  274 erSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15056 258 --YRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRR 292
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
63-310 2.75e-06

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 48.25  E-value: 2.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15333  33 RKLHTPANYLIASLAVTDLLVsILVMPISIVYTVTGTWTLGQVVCDIWLSSDITCCTASILHLCVIALDRYWAITDAVEY 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCsalypedTVYSWRHFHTLRMTIFCLVLPLLVMAICYTG 221
Cdd:cd15333 113 SKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSEC-------VVNTDHILYTVYSTVGAFYIPTLLLIALYGR 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  222 IiktlLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHLDLVMLV-TEVIAYSHCCMNPVI 300
Cdd:cd15333 186 I----YVEARARERKATKTLGIILGAFIVCWLPFFIISLVLPI--------CKDACWFHLAIFDfFTWLGYLNSLINPII 253
                       250
                ....*....|
gi 4502637  301 YAFVGERFRK 310
Cdd:cd15333 254 YTMSNEDFKQ 263
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
63-309 2.82e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 48.00  E-value: 2.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLL--FLVTLPFWIHYVRGHNWVFGHGMCKLLsgFYHTGLYS--EIFFIILLTIDRYLAIVHA 138
Cdd:cd15304  29 KKLQNATNYFLMSLAIADMLlgFLVMPVSMLTILYGYRWPLPSKLCAVW--IYLDVLFStaSIMHLCAISLDRYIAIRNP 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  139 VFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVyswrhfhTLRMTIFCLVLPLLVMAIC 218
Cdd:cd15304 107 IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENF-------VLIGSFVAFFIPLTIMVIT 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  219 YTGIIKTLLRCPSKKKyKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHLDLVMLVTEV---IAYSHCC 295
Cdd:cd15304 180 YFLTIKSLQQSISNEQ-KASKVLGIVFFLFVVMWCPFFITNVMAVI--------CKESCNEVVIGGLLNVfvwIGYLSSA 250
                       250
                ....*....|....
gi 4502637  296 MNPVIYAFVGERFR 309
Cdd:cd15304 251 VNPLVYTLFNKTYR 264
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
57-309 3.25e-06

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 47.89  E-value: 3.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLLNLAISDLLFLV--TLPFWIHYVRGHnWVFGHGMCKLLSGF-YHTGLYSEiFFIILLTIDRYL 133
Cdd:cd15076  23 FVTIKYKKLRQPLNYILVNISLAGFIFCIfsVFPVFVASAQGY-FFFGRTVCALEAFVgSLAGLVTG-WSLAFLAFERYI 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  134 AIVHAVFALRARTvTFGVITSIVTWGLAVLAALPEFIfYETEELFEETLCSA---LYPEDTVYSwRHFHTLRMTIFCLVL 210
Cdd:cd15076 101 VICKPFGNFRFGS-KHALGAVVATWIIGIGVSLPPFF-GWSRYIPEGLQCSCgpdWYTVGTKYR-SEYYTWFLFIFCFIV 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  211 PLLVMAICYTGIIKTLLRCPSKKKYKAI---------RLIFVIMAVFFIFWTPYNVAillssyqSILFGNDCERSKHLDL 281
Cdd:cd15076 178 PLSIIIFSYSQLLGALRAVAAQQQESAStqkaerevsRMVVVMVGSFCLCYVPYAAL-------AMYMVNNRDHGLDLRL 250
                       250       260
                ....*....|....*....|....*...
gi 4502637  282 VMlVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15076 251 VT-IPAFFSKSSCVYNPIIYCFMNKQFR 277
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
63-310 3.41e-06

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 48.01  E-value: 3.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15323  29 RALRAPQNLFLVSLASADILVaTLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEelfeetlcsalyPEDTVYSW-----RHFHTLRMTIFCLVLPLLVMA 216
Cdd:cd15323 109 NLKRTPRRVKAIIVTVWLISAVISFPPLISMYRD------------PEGDVYPQcklndETWYILSSCIGSFFAPCLIMI 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  217 ICYTGIIKTllrcpSKKKYKAIRLIF-VIMAVFFIFWTPYnvailLSSYQsiLFGNDCERSKHLDLVMLVTEVIAYSHCC 295
Cdd:cd15323 177 LVYIRIYRV-----AKAREKRFTFVLaVVMGVFVVCWFPF-----FFSYS--LYGICREACEVPEPLFKFFFWIGYCNSS 244
                       250
                ....*....|....*
gi 4502637  296 MNPVIYAFVGERFRK 310
Cdd:cd15323 245 LNPVIYTIFNQDFRR 259
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
37-310 3.46e-06

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 48.30  E-value: 3.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   37 VPPLYSLVFTVGLLGNVVVVMILIKYRRLRIM---TNIYLLNLAISDLL-FLVTLP------FWIHyvrgHNWVFGHGMC 106
Cdd:cd15355   3 VTAIYLALFVVGTVGNSITLYTLARKKSLQHLqstVHYHLASLALSDLLiLLLAMPvelynfIWVH----HPWAFGDAAC 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  107 KllsGFY---HTGLYSEIFFIILLTIDRYLAIVHAVFA--LRARTVTFGVITSIvtWGLAVLAALPEFIFYETEELFEE- 180
Cdd:cd15355  79 R---GYYflrDACTYATALNVASLSVERYLAICHPFKAksLMSRSRTKKFISAI--WLASALLAIPMLFTMGEQNRSGTh 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  181 ---TLCSALYPEDTVYSWRHFHTLrmtiFCLVLPLLVMAICYTGIIKTLLRCPSKKKYK--------------------- 236
Cdd:cd15355 154 pggLICTPIVDTSTLKVVIQVNAF----LSFLFPMLVISVLNTLIANQLTVMVNQAEQEnqvctiggqrtvlsvsmepgr 229
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  237 ------AIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLvTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15355 230 vqslrhGVLVLRAVVIAFVVCWLPYHVRRLMFCYVSDEQWTTFLYDFYHYFYML-TNVLFYVSSAINPILYNLVSANFRQ 308
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
58-303 3.99e-06

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 47.81  E-value: 3.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVF-GHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV 136
Cdd:cd14964  22 SLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSrPQALCYLIYLLWYGANLASIWTTLVLTYHRYFALC 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  137 HAVFALRARTVTFGVITSIVTWGLAVLAALPefifyETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMA 216
Cdd:cd14964 102 GPLKYTRLSSPGKTRVIILGCWGVSLLLSIP-----PLVGKGAIPRYNTLTGSCYLICTTIYLTWGFLLVSFLLPLVAFL 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  217 ICYTGIIKTLLRCPSK----------KKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGndcerskhLDLVMLVT 286
Cdd:cd14964 177 VIFSRIVLRLRRRVRAirsaaslntdKNLKATKSLLILVITFLLCWLPFSIVFILHALVAAGQG--------LNLLSILA 248
                       250
                ....*....|....*..
gi 4502637  287 EVIAYSHCCMNPVIYAF 303
Cdd:cd14964 249 NLLAVLASTLNPFIYCL 265
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
59-303 5.64e-06

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 47.29  E-value: 5.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRIMTNIYLLNLAISDLL------FLVTLPFWIHY-VRGHNWVFghgmcklLSGFYHTGLYSEIFFIILLTIDR 131
Cdd:cd14972  23 IIKNRRLHKPMYILIANLAAADLLagiafvFTFLSVLLVSLtPSPATWLL-------RKGSLVLSLLASAYSLLAIAVDR 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  132 YLAIVHAVFALRARTVTFGVITSIVTWGLAV-LAALPEFifYETEELFEETLCSALYPEDTVyswrhfhtlRMTIFCLV- 209
Cdd:cd14972  96 YISIVHGLTYVNNVTNKRVKVLIALVWVWSVlLALLPVL--GWNCVLCDQESCSPLGPGLPK---------SYLVLILVf 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  210 --LPLLVMAICYTGI----------IKTLLRC-----PSKKKYKAIRLIfVIMAVFFIFWTPYNVAILLssyqSILFGND 272
Cdd:cd14972 165 ffIALVIIVFLYVRIfwclwrhanaIAARQEAavpaqPSTSRKLAKTVV-IVLGVFLVCWLPLLILLVL----DVLCPSV 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 4502637  273 CERSKHLDLVMlvteVIAYSHCCMNPVIYAF 303
Cdd:cd14972 240 CDIQAVFYYFL----VLALLNSAINPIIYAF 266
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
57-310 7.28e-06

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 47.14  E-value: 7.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd15008  22 LVIHRSRRTQSTTNYFVVSMACADLLLSVAsAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVLLSICVDRFYTI 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHAVFALRARTVTFGVITSivTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFhtlrmtIFCLVLPLLVM 215
Cdd:cd15008 102 VYPLSFKVSREKAKKMIAA--SWLFDAAFVSPALFFYGSNWGPHCNFFLPDSWDGAAYAIIHL------LVGFLVPSILI 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  216 AICYTGIIKTLLRCPS-------------KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSyqsilFGNDCERSKhldLV 282
Cdd:cd15008 174 ILFYQKVIKYIWRIGTdgrtvrrtmnivpRTKVKTIKMFLMLNSMFLLSWLPFYVVQLWHP-----RESDYRQSS---LV 245
                       250       260
                ....*....|....*....|....*...
gi 4502637  283 MLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15008 246 FLAVTWISFSSSASKPTLYSVYNANFRR 273
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
63-310 7.37e-06

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 46.84  E-value: 7.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFA 141
Cdd:cd15321  35 RSLRAPQNLFLVSLAAADILVaTLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEY 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYswrhfhTLRMTIFCLVLPLLVMAICYtg 221
Cdd:cd15321 115 NSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQCKLNEEAWY------ILSSSIGSFFAPCLIMILVY-- 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  222 iiktlLRCPSKKKYKAIRLIF---VIMAVFFIFWTPYnvaILLSSYQSILfgndCERSKHLDLVMLVTEVIAYSHCCMNP 298
Cdd:cd15321 187 -----LRIYLIAKNREKRFTFvlaVVIGVFVLCWFPF---FFSYSLGAIC----PELCKVPHSLFQFFFWIGYCNSSLNP 254
                       250
                ....*....|..
gi 4502637  299 VIYAFVGERFRK 310
Cdd:cd15321 255 VIYTIFNQDFRR 266
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
63-312 1.32e-05

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 45.98  E-value: 1.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPFWIHY-VRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVF 140
Cdd:cd15308  29 RALKTTTNYFIVSLAVADLLLaLLVLPLYVYSeFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCAISVDRFIAVSVPLN 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  141 ALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSwrhfhtlrmTIFCLVLPLLVMAICYT 220
Cdd:cd15308 109 YNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNRDPAVCKLEDNNYVVYS---------SVCSFFIPCPVMLVLYC 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  221 GIIKTLLRcpskkKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHLDLVMLVTEVIAYSHCCMNPVI 300
Cdd:cd15308 180 AMFRGLGR-----ERKAMRVLPVVVGAFLFCWTPFFVVHITRAL--------CESCSIPPQLISIVTWLGYVNSALNPVI 246
                       250
                ....*....|..
gi 4502637  301 YAFVGERFRKYL 312
Cdd:cd15308 247 YTVFNAEFRNVF 258
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
62-312 1.42e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 46.01  E-value: 1.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   62 YRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVF 140
Cdd:cd15318  28 FKALHTPTNFLLLSLALADMLLgLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISIDRHCAICDPLL 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  141 ALRARTVTFGVITSIVTWGLAVL--------AALPEFIFYETEELFEETLCSALYpeDTVYSWRHFHTLRMTIFCLV--- 209
Cdd:cd15318 108 YPSKFTIRVACIFIAAGWLVPTVytsvflytKAVEEGLAELLTSVPCVGSCQLLY--NKLWGWLNFPVFFIPCLIMIgly 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  210 LPLLVMAICYTGIIKTLL---RCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGndcerskhlDLVMLVT 286
Cdd:cd15318 186 VKIFIVAKRQARAIASLLsdtNGASKRERKAAKTLGIAVGVYLLCWLPFTIDTMVDSLLNFITP---------PLLFDII 256
                       250       260
                ....*....|....*....|....*.
gi 4502637  287 EVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15318 257 IWFAYFNSACNPLIYVFSYPWFRKAL 282
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
58-311 1.60e-05

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 46.00  E-value: 1.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVF-GHGMCkLLSGFY--HTGLYSeIFFIILLTIDRYLA 134
Cdd:cd15085  24 VTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYlGDAFC-IFQGFAvnYFGIVS-LWSLTLLAYERYNV 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  135 IVHAVFALRARTVTfGVITSIVTWGLAVL-AALPEFIFYETEELFEETLCSALYPEDtvySWRHF-HTLRMTIFCLVLPL 212
Cdd:cd15085 102 VCKPMGGLKLSTKR-GYQGLLFIWLFCLFwAVAPLFGWSSYGPEGVQTSCSIGWEER---SWSNYsYLILYFLMCFVIPV 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  213 LVMAICYTGIIKTLLR------------CPSKKKyKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNdcerskhlD 280
Cdd:cd15085 178 AIIGFSYGNVLRSLHKlnkkieqqggknCPEEEE-RAVIMVLAMVIAFLICWLPYTVFALIVVVNPELSIS--------P 248
                       250       260       270
                ....*....|....*....|....*....|.
gi 4502637  281 LVMLVTEVIAYSHCCMNPVIYAFVGERFRKY 311
Cdd:cd15085 249 LAATMPTYFAKTSPVYNPIIYIFLNKQFRES 279
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
104-303 2.26e-05

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 45.58  E-value: 2.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  104 GMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTV-TFGVITSivTWGLAVLAALPEFIFYETeelfeetl 182
Cdd:cd15385  71 FLCRIVKHLQVLGMFASTYMLVMMTADRYIAICHPLKTLQQPTKrSYLMIGS--AWALSFILSTPQYFIFSL-------- 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  183 cSALYPEDTVYS-WRHF--------HTLRMTIFCLVLPLLVMAICYTGI---IKTLLRCP-------------------- 230
Cdd:cd15385 141 -SEIENGSGVYDcWANFivpwgikaYITWITISIFVVPVIILLTCYGFIcynIWRNIKCKtrrglsdnalknillavcvs 219
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502637  231 -----SKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCErskhlDLVMLVTEVIAYSHCCMNPVIYAF 303
Cdd:cd15385 220 svktiSRAKIRTVKMTFVIVLAYIVCWAPFFTIQMWSVWDQNFPWDESE-----NTAVTITALLASLNSCCNPWIYMF 292
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
59-310 2.29e-05

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 45.76  E-value: 2.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRI-MTNIYLLNLAISDLLFLVTLPFW--IHYVRGHnWVFGhGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAI 135
Cdd:cd15320  26 VIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWkaVAEIAGF-WPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAI 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  136 VHAVFALRARTVTFGVITSIVTWGLAVLAA-LPEFIFYETEELFEETLCSALYPEDTV----YSWRHFHTLRMTIFCLVL 210
Cdd:cd15320 104 SSPFRYERKMTPKVAFIMISVAWTLSVLISfIPVQLNWHKAKPTSFLDLNASLRDLTMdncdSSLNRTYAISSSLISFYI 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  211 PLLVMAICYTGIIK--------------------------------------TLLRCPSKKKYKAIRLIFVIMAVFFIFW 252
Cdd:cd15320 184 PVAIMIVTYTRIYRiaqkqirrisaleraavhakncqnstgnrgsgdcqqpeSSFKMSFKRETKVLKTLSVIMGVFVCCW 263
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4502637  253 TPYNVAILLSSY-QSILFGNDCERSKHLDLVMLvtevIAYSHCCMNPVIYAFVGErFRK 310
Cdd:cd15320 264 LPFFILNCMVPFcKPTSTEPFCISSTTFDVFVW----FGWANSSLNPIIYAFNAD-FRK 317
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
63-317 2.40e-05

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 45.28  E-value: 2.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLL--FLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVF 140
Cdd:cd15305  29 KKLQNATNFFLMSLAVADMLvgILVMPVSLIAILYDYAWPLPRYLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIE 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  141 ALRARTVTFGVITSIVTWGLAVLAALP-EFIFYETEELFEETLCSALYPEDTVyswrhfhtLRMTIFCLVLPLLVMAICY 219
Cdd:cd15305 109 HSRFNSRTKAMMKIAAVWTISIGISMPiPVIGLQDDEKVFVNGTCVLNDENFV--------LIGSFVAFFIPLIIMVITY 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  220 TGIIKTLLRCPS-KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHLDLVMLVTEV---IAYSHCC 295
Cdd:cd15305 181 CLTIQVLQRQQAiNNERRASKVLGIVFFLFLIMWCPFFITNILSVL--------CKEACDQKLMEELLNVfvwVGYVSSG 252
                       250       260
                ....*....|....*....|..
gi 4502637  296 MNPVIYAFVGERFRKYLRHFFH 317
Cdd:cd15305 253 INPLVYTLFNKTYRRAFSNYIR 274
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
59-310 3.34e-05

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 44.85  E-value: 3.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd15316  25 ILHFKQLHSPTNFLIASLACADFLVGVTvMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYASLFHLCFISVDRYIAVTD 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPEF--------IFYETEELFEETLCSALYPEDTVYswrhfhtlrMTIFCLV 209
Cdd:cd15316 105 PLVYPTKFTVSVSGICISVSWIFSLTYSFSVFytgvnddgLEELVNALNCVGGCQIILNQNWVL---------VDFLLFF 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  210 LPLLVMAICYTGIIKTLLRCP---------------------SKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSIL 268
Cdd:cd15316 176 IPTFAMIILYGKIFLVAKQQArkiemtsskaesssesykdrvARRERKAAKTLGITVIAFLVSWLPYLIDVLIDAFMNFI 255
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4502637  269 FGndcerskhlDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15316 256 TP---------PYIYEICCWCAYYNSAMNPLIYALFYPWFRK 288
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
60-309 3.52e-05

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 44.82  E-value: 3.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   60 IKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNW-VFGHGMCKlLSGFYHT-GLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd15077  26 IKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYfVLGPLACK-IEGFTATlGGMVSLWSLAVVAFERFLVICK 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTvTFGVITSIVTWGLAVLAALPEfIFYETEELFEETLCSA---LYPEDTVYSwRHFHTLRMTIFCLVLPLLV 214
Cdd:cd15077 105 PLGNFTFRG-THAIIGCIATWVFGLAASLPP-LFGWSRYIPEGLQCSCgpdWYTTNNKWN-NESYVMFLFCFCFGVPLSI 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  215 MAICYTGIIKTLLRCPSKKKYKA---------IRLIFVIMAVFFIFWTPYNVAILLSSYQsilfgndceRSKHLDLVML- 284
Cdd:cd15077 182 IVFSYGRLLLTLRAVAKQQEQSAstqkaerevTKMVVVMVLGFLVCWLPYASFALWVVTN---------RGEPFDLRLAs 252
                       250       260
                ....*....|....*....|....*
gi 4502637  285 VTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15077 253 IPSVFSKASTVYNPVIYVFMNKQFR 277
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
60-312 4.14e-05

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 44.85  E-value: 4.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   60 IKYRRLRIMTNIYLLNLAISDLL---FLVTLPFwIHYVRGHnWVFGHGMCKL------LSGFyhTGLYSeiffIILLTID 130
Cdd:cd15084  36 IKYKKLRSPLNYILVNLAVADLLvtlFGSSVSF-SNNIVGF-FVFGKTMCEFegfmvsLTGI--VGLWS----LAILAFE 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  131 RYLAIVHAV--FALRARTVTFGVItsiVTWGLAVLAALPEFIFYeteelfeetlcSALYPEDTVYS----W------RHF 198
Cdd:cd15084 108 RYLVICKPMgdFRFQQRHAVSGCA---FTWGWSLLWTSPPLFGW-----------SSYVPEGLRTScgpnWytggtnNNS 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  199 HTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKK---------YKAIRLIFVIMAVFFIFWTPYNV-AILLSSYQSIL 268
Cdd:cd15084 174 YILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKesettqraeKEVTRMVIAMVMAFLICWLPYATfAMVVATNKDVV 253
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4502637  269 FGndcerskhlDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15084 254 IQ---------PTLASLPSYFSKTATVYNPIIYVFMNKQFRSCL 288
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
59-310 7.09e-05

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 43.78  E-value: 7.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFgHGmCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd14968  25 VKLNRALRTVTNYFIVSLAVADILVgALAIPLAILISLGLPTNF-HG-CLFMACLVLVLTQSSIFSLLAIAIDRYLAIKI 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AV--FALRARTVTFGVITsiVTWGLAVLAAL-PEFIFYETEELFEETLCSALYPE-DTVYSWRhfhtlRMTIF----CLV 209
Cdd:cd14968 103 PLryKSLVTGRRAWGAIA--VCWVLSFLVGLtPMFGWNNGAPLESGCGEGGIQCLfEEVIPMD-----YMVYFnffaCVL 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  210 LPLLVMAICYTGI---IKTLLRCPS------------KKKYKAIRLIFVIMAVFFIFWTPynvailLSSYQSI-LFgndC 273
Cdd:cd14968 176 VPLLIMLVIYLRIfrvIRKQLRQIEsllrsrrsrstlQKEVKAAKSLAIILFLFALCWLP------LHIINCItLF---C 246
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4502637  274 ERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd14968 247 PECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQ 283
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
61-301 9.13e-05

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 43.74  E-value: 9.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   61 KYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAV 139
Cdd:cd15958  27 RTQRLQTLTNLFITSLACADLVMgLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTASIETLCVIAIDRYLAITSPF 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  140 F--ALRARTVTFGVITSIvtWGLAVLAA-LPEFIFYETEELFEETLCSAlYPEDTVYSWRHFHTLRMTIFCLVLPLLVMA 216
Cdd:cd15958 107 RyqSLLTRARAKGIVCTV--WAISALVSfLPIMMHWWRDEDDQALKCYE-DPGCCDFVTNRAYAIASSIISFYIPLLIMI 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  217 ICY-------------------------TGIIKTLLRCPSK----KKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSI 267
Cdd:cd15958 184 FVYlrvyreakkqikkidkcegrfhntlTGLGRKCKRRPSRilalREQKALKTLGIIMGVFTLCWLPFFLVNVVNVFNRE 263
                       250       260       270
                ....*....|....*....|....*....|....
gi 4502637  268 LFGndcerskhlDLVMLVTEVIAYSHCCMNPVIY 301
Cdd:cd15958 264 LVP---------DWLFVFFNWLGYANSAFNPIIY 288
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
63-309 9.27e-05

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 43.50  E-value: 9.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLFLV-TLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFa 141
Cdd:cd15331  29 RSLQGVSNYLILSLAVADLMVAVlVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCCTASILHLVAIALDRYWAVTNIDY- 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  142 LRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEetlcSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTG 221
Cdd:cd15331 108 IRRRTAKRILIMIAVVWFVSLIISIAPLFGWKDEDDLD----RVLKTGVCLISQDYGYTIFSTVGAFYVPLLLMIIIYWK 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  222 IIKTllrcpSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndCERSKHLDLVMLVTEVIAYSHCCMNPVIY 301
Cdd:cd15331 184 IYQA-----AKRERKAARTLAIITGAFVVCWLPFFLVALVMPF--------CGAWQISRFLESFFLWLGYFNSLLNPIIY 250

                ....*...
gi 4502637  302 AFVGERFR 309
Cdd:cd15331 251 TIFSPDFR 258
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
40-310 1.08e-04

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 43.32  E-value: 1.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   40 LYSLVFTVGLLGNVVVVMILIKYRRLRIMTNI---YLLNLAISDLLFL-VTLPF------WIHYvrghNWVFGHGMCKLL 109
Cdd:cd15356   6 VYALIWALGAAGNALTIHLVLKKRSLRGLQGTvhyHLVSLALSDLLILlISVPIelynfvWFHY----PWVFGDLVCRGY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  110 SGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALP---------EFIFYETEELFEE 180
Cdd:cd15356  82 YFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPmafimgqkyELETADGEPEPSS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  181 TLCSALYPEDTVYSWRHFHTLrmtiFCLVLPLLVMAIcYTGIIKTLLRCPSKKKykAIRLIFVIMAVFFIFWTPYNVAIL 260
Cdd:cd15356 162 RVCTVLVSRATLKVFIQVNAF----VSFVLPLALIAF-LNGVTVSHLRIQSLQH--SVQVLRAIVIAYVICWLPYHARRL 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 4502637  261 LSSYQSILFGNDCERSKHLDLVMLvTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15356 235 MFCYVPDDAWTDSLYNFYHYFYML-TNTLFYVSSAVNPLLYNVVSSSFRK 283
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
59-309 1.23e-04

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 43.12  E-value: 1.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRIMTNIYLLNLAISDLLFLVTLPF--WIHYVRghNWVFGHGMCKL--LSGFYhTGLySEIFFIILLTIDRYLA 134
Cdd:cd15072  25 FCKTRELRTPSNLLVLSLAVADMGISLNALVaaSSSLLR--RWPYGSEGCQAhgFQGFF-TAL-ASICSSAAIAWDRYHH 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  135 IVHAVFaLRARTVtfgVITSIVTWGLAVL-AALPEFIFYETEELFEETLCSALYPEdtvySWRHF--HTLRMTIFCLVLP 211
Cdd:cd15072 101 YCTRSK-LQWSTA---ISLVLFVWLFSAFwAAMPLLGWGEYDYEPLGTCCTLDYSK----GDRNYvsYLFTMAFFNFILP 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  212 LLVMAICYTGIIKTLLrcpSKKKYKAIRLIFVIMavFFIFWTPYnvaILLSSYQSILFGNDCERSKHldlvmLVTEVIAY 291
Cdd:cd15072 173 LFILLTSYSSIEQKLK---KEGHLRFNTGLPLLT--LLICWGPY---AILALYAAITDVTSISPKLR-----MVPALLAK 239
                       250
                ....*....|....*...
gi 4502637  292 SHCCMNPVIYAFVGERFR 309
Cdd:cd15072 240 TSPTINAILYALGNENYR 257
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
57-308 1.84e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 42.86  E-value: 1.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMT--NIYLLNLAISDL---LFLVtLPFWIHYVRgHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDR 131
Cdd:cd15386  21 VLLAMYRMRRKMSrmHLFVLHLALTDLvvaLFQV-LPQLIWEIT-YRFQGPDLLCRAVKYLQVLSMFASTYMLIMMTVDR 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  132 YLAIVHAVFALRARTVTFGVITSiVTWGLAVLAALPE---FIFYETEELFEETLCSAlypeDTVYSW--RHFHT-LRMTI 205
Cdd:cd15386  99 YIAVCHPLRTLQQPSRQAYLMIG-ATWLLSCILSLPQvfiFSLREVDQGSGVLDCWA----DFGFPWgaKAYITwTTLSI 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  206 FclVLPLLVMAICYT----GIIKTL-------------------------LRCPSKKKYKAIRLIFVIMAVFFIFWTPYn 256
Cdd:cd15386 174 F--VLPVAILIVCYSlicyEICKNLkgktqtsrsegggwrtqgmpsrvssVRTISRAKIRTVKMTFVIVLAYIACWAPF- 250
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 4502637  257 vailLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERF 308
Cdd:cd15386 251 ----FSVQMWSVWDENAPDEDSSDFAFTITMLLASLSSCCNPWIYMFFSGHL 298
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
62-312 2.48e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 42.43  E-value: 2.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   62 YRRLRIMTNIYLLNLAISD-LLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVF 140
Cdd:cd15317  28 FKQLHSPTNMLVLSLATADfLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTTSIFHLCFIAIDRYYAVCDPLR 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  141 ALRARTVTFGVITSIVTWGLAVLAALPeFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYT 220
Cdd:cd15317 108 YPSKITVQVAWRFIAIGWLVPGIYTFG-LIYTGANDEGLEEYSSEISCVGGCQLLFNKIWVLLDFLTFFIPCLIMIGLYA 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  221 GI----------IKTLLRC--PSKKKY---------KAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNdcerskhl 279
Cdd:cd15317 187 KIflvarrqarkIQNMEDKfrSSEENSskasasrerKAAKTLAIVMGIFLFCWLPYFIDTIVDEYSNFITPA-------- 258
                       250       260       270
                ....*....|....*....|....*....|...
gi 4502637  280 dLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15317 259 -IVFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
75-301 2.72e-04

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 41.86  E-value: 2.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   75 NLAISDLLF--LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV-HAVFALRARTVTFGV 151
Cdd:cd15328  41 SMAVSDVLVaaLVMPLSLVHELSGRRWQLGRSLCQVWISFDVLCCTASIWNVTAIALDRYWSITrHLEYTLRTRRRISNV 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  152 ITSIvTWGL-AVLAALPEFIFYETEELFEETLCS-ALYPEDTVYSwrhfhtlrmTIFCLVLPLLVMAICYTGIIKTllrc 229
Cdd:cd15328 121 MIAL-TWALsAVISLAPLLFGWGETYSEDSEECQvSQEPSYTVFS---------TFGAFYLPLCVVLFVYWKIYKA---- 186
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502637  230 pSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSilfgndCERSKHLDLVMLvteVIAYSHCCMNPVIY 301
Cdd:cd15328 187 -AQKEKRAALMVGILIGVFVLCWIPFFLTELISPLCS------CDIPPIWKSIFL---WLGYSNSFFNPLIY 248
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
59-301 3.14e-04

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 42.16  E-value: 3.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   59 LIKYRRLRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVH 137
Cdd:cd15957  25 IAKFERLQTVTNYFITSLACADLVMgLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITS 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAA-LPEFIFYETEELFEETLCsalYPEDTV--YSWRHFHTLRMTIFCLVLPLLV 214
Cdd:cd15957 105 PFKYQSLLTKNKARVIILMVWIVSGLTSfLPIQMHWYRATHQEAINC---YAEETCcdFFTNQAYAIASSIVSFYVPLVI 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  215 MAICYTGIIKTLLRCPSK--------------------------------KKYKAIRLIFVIMAVFFIFWTPYNVAILLS 262
Cdd:cd15957 182 MVFVYSRVFQEAKRQLQKidksegrfhnqnidqngsgggggnrrrskfclKEHKALKTLGIIMGTFTLCWLPFFIVNIVH 261
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4502637  263 SYQSILFgndcerskhLDLVMLVTEVIAYSHCCMNPVIY 301
Cdd:cd15957 262 VIQDNLI---------RKEVYILLNWIGYVNSGFNPLIY 291
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
105-317 3.42e-04

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 42.11  E-value: 3.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  105 MCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVitsIVTWGLAVLAALPE-FIFYETEELFEETLC 183
Cdd:cd15387  72 LCRLVKYLQVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVYV---LFSWLLSLVFSIPQvHIFSLREVGNGVYDC 148
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  184 SAlypeDTVYSW-RHFHTLRMTIFCLVLPLLVMAICYTGI---------IKTL----------------------LRCPS 231
Cdd:cd15387 149 WA----DFIQPWgPKAYITWITLSVYIIPVLILSVCYGLIsfkiwqnvkLKTRretktplssaasggaalarvssVKLIS 224
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  232 KKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgnDCERSKHLDLVMLVTEVIAYSHCCmNPVIYAFvgerfrkY 311
Cdd:cd15387 225 KAKIRTVKMTFVIVLAYIVCWTPFFFVQMWSVW-------DPNAPKEASPFIIAMLLASLNSCC-NPWIYMF-------F 289

                ....*.
gi 4502637  312 LRHFFH 317
Cdd:cd15387 290 TGHLFH 295
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
72-309 3.82e-04

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 41.69  E-value: 3.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   72 YLLNLAISDLL---FLVTLPFWIHYVRGHNWVfGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHavfALRARTVT 148
Cdd:cd15129  39 YLLALTASDILtqvFIIFVGFILQTAILAREV-PHALIHTVSVLEFAANHASIWITVLLTVDRYVALCH---PLRYRAVS 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  149 FGVITSIV---TWGLAVLAALPEFIFYETEELFeetlcSALYPEDTVYSWRHFHTLRMtIFCLVLPLLVMAICYTGIIKT 225
Cdd:cd15129 115 YPERTRRIiaaVFVAALATGIPFYWWSDMWRDS-----HPPTTLDKVLKWTHCFIIYF-IPCTIFLVTNSVIIHKLRRRK 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  226 LLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSilfgnDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVG 305
Cdd:cd15129 189 GRSGPQRRSGKTTAILLAITTVFAVLWAPRTVVIIYHLYVS-----SVNRDWRVHLALDLANMLAMLNTAVNFFLYCFVS 263

                ....
gi 4502637  306 ERFR 309
Cdd:cd15129 264 KRFR 267
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
57-167 3.95e-04

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 41.94  E-value: 3.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLLNLAISDLL-FLVTLPFWIHYVR-GHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLA 134
Cdd:cd15218  23 ILLVKDKTLHRAPYYFLLDLCCSDILrSAICFPFVFTSVKnGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRYLA 102
                        90       100       110
                ....*....|....*....|....*....|...
gi 4502637  135 IVHAVFALRARTVTFGVITSIVTWGLAVLAALP 167
Cdd:cd15218 103 IAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFP 135
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
68-312 5.73e-04

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 41.07  E-value: 5.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   68 MTNIYLLNLAISDLLFlvtlpFWIHYVRGHNWvFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAvFALRARTV 147
Cdd:cd14980  49 LMGIYLLIIAIADQYY-----RGRYAQYSEEW-LRSPPCLLACFLVSLSSLMSVLMMLLITLDRYICIVYP-FSNKRLSY 121
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  148 TFGVITSIVTWGLA-VLAALP----EFIFYETEELFEETLCSALYPEDTVY-SWrhfhtlrMTIFCL--VLPLLVMAICY 219
Cdd:cd14980 122 KSAKIILILGWLFSiIFAAIPilysINQPGDNRLYGYSSICMPSNVSNPYYrGW-------LIAYLLltFIAWIIICILY 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  220 TGIIKTLLRC--------PSKKKYKAIRLiFVIMAVFFIFWTPYNVAILLSSYQSILfgndcerskhLDLVML--VTEVI 289
Cdd:cd14980 195 ILIFISVRKSrksarrssSKRDKRIAIRL-ALILITDLICWLPYYIVIFSGLLTSTE----------IDIHVLqfIAILA 263
                       250       260
                ....*....|....*....|...
gi 4502637  290 AYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd14980 264 LPLNSAINPYLYTLTTPTFKRDF 286
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
61-309 1.07e-03

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 40.28  E-value: 1.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   61 KYRRLRIMTNIYLLNLAISDL---LFLVTLPFwIHYVRGHnWVFGHGMCkLLSGFYH-----TGLYSeiffIILLTIDRY 132
Cdd:cd15081  39 KFKKLRHPLNWILVNLAIADLgetVIASTISV-VNQIFGY-FILGHPMC-VLEGFTVsvcgiTGLWS----LTIISWERW 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  133 LAIVHAVFALR--ARTVTFGVITSIVtWGlAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVL 210
Cdd:cd15081 112 VVVCKPFGNIKfdGKLAIVGIIFSWV-WS-AVWCAPPIFGWSRYWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMITCCII 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  211 PLLVMAICYTGI---IKTLLRC-----PSKKKYKAIRLIFVIMAVFFIF-WTPYN-VAILLSSYQSILFGndcerskhlD 280
Cdd:cd15081 190 PLAIIILCYLQVwlaIRAVAQQqkeseSTQKAEKEVSRMVVVMIFAYCFcWGPYTfFACFAAANPGYAFH---------P 260
                       250       260
                ....*....|....*....|....*....
gi 4502637  281 LVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15081 261 LAAALPAYFAKSATIYNPIIYVFMNRQFR 289
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
64-301 1.07e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 40.28  E-value: 1.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   64 RLRIMTNIYLLNLAISDLL--FLVTLPFWIHYVRGHnWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHA--- 138
Cdd:cd15959  30 RLQTMTNVFVTSLACADLVmgLLVVPPGATILLTGH-WPLGTTVCELWTSVDVLCVTASIETLCAIAVDRYLAITNPlry 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  139 ---VFALRARTVTfgvitsIVTWglaVLAALPEFIFYETEELFEETLCSALY----PEDTVYSWRHFHTLRMTIFCLVLP 211
Cdd:cd15959 109 ealVTKRRARTAV------CLVW---AISAAISFLPIMNQWWRDGADEEAQRcydnPRCCDFVTNMPYAIVSSTVSFYVP 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  212 LLVMAICYTGII-----------KTLLRCPSK---------------------KKYKAIRLIFVIMAVFFIFWTPYNVAI 259
Cdd:cd15959 180 LLVMIFVYVRVFvvatrqvrlirKDKVRFPPEesppaesrpacgrrpsrllaiKEHKALKTLGIIMGTFTLCWLPFFVAN 259
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4502637  260 LLSSYQsilfgndceRSKHLDLVMLVTEVIAYSHCCMNPVIY 301
Cdd:cd15959 260 IIKVFC---------RSLVPDPAFLFLNWLGYANSAFNPIIY 292
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
71-318 1.37e-03

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 40.08  E-value: 1.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   71 IYLLNLAISDLLFLV-----TLPFWIHYvrgHNWVFGHGMCKLLSGF-----YHTGLYseifFIILLTIDRYLAIVHAVF 140
Cdd:cd15110  36 VYILHLAIADFTFLLcifilSIMYIGPF---NFSHSRDYVAMLIFIIlflfgYNTGLY----LLTAISVERCLSVLYPIW 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  141 ALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYpedtvyswrhfhtlrmtIFCLVLPLLVMA---I 217
Cdd:cd15110 109 YRCHRPKHQSAIVCGLLWALSVLMTSLEYLMCIDEGFHVRNECRAVL-----------------IFIGILTFLVFTplmL 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  218 CYTGIIKTLLRCPSKKKYKAiRLIFVIMA---VFFIFWTPYNVAILLSSYQSILFGNDCErskhldlvmlVTEVIAYSHC 294
Cdd:cd15110 172 ISSLILFIKVRCNSQRRHPG-KLYIIIMLtviFFLIFAMPMRVLLLLNYLHHSSFLFSNP----------VPFLLSTVNS 240
                       250       260
                ....*....|....*....|....*...
gi 4502637  295 CMNPVIYAFVG----ERFRKYLRHFFHR 318
Cdd:cd15110 241 SINPIVYFLVGslrrKRIKKSLKVALQR 268
PHA03234 PHA03234
DNA packaging protein UL33; Provisional
209-309 1.39e-03

DNA packaging protein UL33; Provisional


Pssm-ID: 177562 [Multi-domain]  Cd Length: 338  Bit Score: 40.31  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   209 VLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEV 288
Cdd:PHA03234 207 IFPTMIFSFFYVIFCKALHALTEKKHKKTLFFIRILILSFLCIQIPNIAILICEIAFLYIANNSCFGLAQREILQIIIRL 286
                         90       100
                 ....*....|....*....|.
gi 4502637   289 IAYSHCCMNPVIYAFVGERFR 309
Cdd:PHA03234 287 MPEIHCFSNPLVYAFTGGDFR 307
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
62-310 1.50e-03

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 40.03  E-value: 1.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   62 YRRLRIMTNIYLLNLAISD-LLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHavf 140
Cdd:cd15312  28 FKQLHSPTNFLILSLAITDfLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHLCFIAVDRYYAVCD--- 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  141 ALRART-VTFGVITSI--VTWGLAVLAA----LPEFIFYETEELFEETLCSALYPedtVYSWRHFHTLRMTIfCLVLPLL 213
Cdd:cd15312 105 PLHYRTkITTPVIKVFlvISWSVPCLFAfgvvFSEVNLEGIEDYVALVSCTGSCV---LIFNKLWGVIASLI-AFFIPGT 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  214 VMAICYTGI----------IKTLLRCP---------SKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCe 274
Cdd:cd15312 181 VMIGIYIKIffvarkhakvINNRPSVTkgdsknklsKKKERKAAKTLSIVMGVFLLCWLPFFVATLIDPFLNFSTPVDL- 259
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4502637  275 rskhLDLVMLvtevIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15312 260 ----FDALVW----LGYFNSTCNPLIYGFFYPWFQK 287
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
65-309 1.79e-03

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 39.53  E-value: 1.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   65 LRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFgHGmCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV------H 137
Cdd:cd15069  31 LQTPTNYFLVSLAAADVAVgLFAIPFAITISLGFCTDF-HS-CLFLACFVLVLTQSSIFSLLAVAVDRYLAIKvplrykS 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTV-------TFGV-ITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLrmtIFCLV 209
Cdd:cd15069 109 LVTGKRARGViavlwvlAFGIgLTPFLGWNKAMSATNNSTNPADHGTNHSCCLISCLFENVVPMSYMVYFNF---FGCVL 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  210 LPLLVMAICYTGII--------KTLL----RCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCErsk 277
Cdd:cd15069 186 PPLLIMLVIYIKIFlvacrqlqRTELmdhsRTTLQREIHAAKSLAIIVGIFALCWLPVHILNCITLFQPEFSKSKPK--- 262
                       250       260       270
                ....*....|....*....|....*....|..
gi 4502637  278 hldLVMLVTEVIAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15069 263 ---WAMNVAILLSHANSVVNPIVYAYRNRDFR 291
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
63-315 3.29e-03

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 38.66  E-value: 3.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   63 RRLRIMTNIYLLNLAISDLLF-LVTLPF-WIHYVRGHNWVFGHGMCKL---LSGFYHTglySEIFFIILLTIDRYLAIVH 137
Cdd:cd15306  29 KKLQYATNYFLMSLAVADLLVgLFVMPIaLLTILFEAMWPLPLVLCPIwlfLDVLFST---ASIMHLCAISLDRYIAIKK 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVyswrHFHTLRMTIFCLVLPLLVMAI 217
Cdd:cd15306 106 PIQASQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERF----GDFILFGSLAAFFTPLAIMIV 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  218 CYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYnvaiLLSSYQSILFgNDCERSKhLDLVMLVTEVIAYSHCCMN 297
Cdd:cd15306 182 TYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPF----FITNITSVLC-DSCNQTT-LQMLMEIFVWIGYVSSGVN 255
                       250
                ....*....|....*...
gi 4502637  298 PVIYAFVGERFRKYLRHF 315
Cdd:cd15306 256 PLVYTLFNKTFRDAFGRY 273
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
65-310 3.80e-03

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 38.76  E-value: 3.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   65 LRIMTNIYLLNLAISDLLF-LVTLPFWIHYVRGHNWVFgHGmCKLLSGFYHTGLYSEIFFIILLTIDRYLAIV------H 137
Cdd:cd15068  31 LQNVTNYFVVSLAAADIAVgVLAIPFAITISTGFCAAC-HG-CLFIACFVLVLTQSSIFSLLAIAIDRYIAIRiplrynG 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  138 AVFALRARtvtfGVITsiVTWGLAVLAALPEFI-----FYETEELFEETLC-----SALYPEDTVYSWRHFHTLrmtIFC 207
Cdd:cd15068 109 LVTGTRAK----GIIA--ICWVLSFAIGLTPMLgwnncGQPKEGKNHSQGCgegqvACLFEDVVPMNYMVYFNF---FAC 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  208 LVLPLLVMAICYTGI----------IKTLLRCPSK------KKYKAIRLIFVIMAVFFIFWTPYNVAILLSsyqsiLFGN 271
Cdd:cd15068 180 VLVPLLLMLGVYLRIflaarrqlkqMESQPLPGERarstlqKEVHAAKSLAIIVGLFALCWLPLHIINCFT-----FFCP 254
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4502637  272 DCERSKHLdlVMLVTEVIAYSHCCMNPVIYAFVGERFRK 310
Cdd:cd15068 255 DCSHAPLW--LMYLAIVLSHTNSVVNPFIYAYRIREFRQ 291
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
44-309 4.11e-03

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 38.69  E-value: 4.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   44 VFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVT-LPFWIHYVRGHNWVFGHG-----MCKLLSGFYHTGL 117
Cdd:cd15975  10 IFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIdIPINVYKLLAQKWPFDDSsfgvfLCKLVPFLQKASV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  118 YSEIFFIILLTIDRYLAIVHAVfalRARTVTFGVITSI---VTWGLAVLAALPEFIFYETEELF----EETLCSALYPED 190
Cdd:cd15975  90 GITVLNLCALSVDRYRAVASWS---RVQGIGIPLITAIeifSIWVLSFILAIPEAIGFVMVPFEyngeQYRTCMLNATTK 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  191 TVYSWRHFHTLRMTIFCLVLPLLVMAICYT-----------GIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAI 259
Cdd:cd15975 167 FMNFYVDAKDWWLFGFYFCVPLACTAIFYTlmtcemlnrrkGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSR 246
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 4502637  260 LLSsyQSILFGNDCERSKHLDLVMLVTEV---IAYSHCCMNPVIYAFVGERFR 309
Cdd:cd15975 247 ILK--KTVYNENDPRRCELLSFLLVMDYIsinLATMNSCINPIALYFVSKKFK 297
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
58-312 4.65e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 38.51  E-value: 4.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   58 ILIKYRRLRI-MTNIYLLNLAISDLLFLVTLPFWIH---YVRGHNwvFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYL 133
Cdd:cd15104  23 ALLKLIRKKDtKSNCFLLNLAIADFLVGLAIPGLATdelLSDGEN--TQKVLCLLRMCFVITSCAASVLSLAAIAFDRYL 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  134 AIVHAV--FALRARTVTFGVITSIvtWGLAVLAALPEFIFYETEELFEETLCSALYPedtvyswRHFHTLRMTIFCLVLP 211
Cdd:cd15104 101 ALKQPLryKQIMTGKSAGALIAGL--WLYSGLIGFLPLISPQFQQTSYKGKCSFFAA-------FHPRVLLVLSCMVFFP 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  212 -LLVMAICYTGIIKT------------------LLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLssyqsILFGND 272
Cdd:cd15104 172 aLLLFVFCYCDILKIarvhsraiykvehalarqIHPRRTLSDFKAARTVAVLIGCFLLSWLPFQITGLV-----QALCDE 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4502637  273 CerskHLDLVMLV-TEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15104 247 C----KLYDVLEDyLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
60-167 4.98e-03

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 38.34  E-value: 4.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   60 IKYRRLRIMTNIYLLNLAISDLL---FLVTLPFWIHYVRG------HNWVFGhGMCKLLsGFYHTgLYSE--IFFIILLT 128
Cdd:cd15137  26 LKYKEENKVHSFLIKNLAIADFLmgvYLLIIASVDLYYRGvyikhdEEWRSS-WLCTFA-GFLAT-LSSEvsVLILTLIT 102
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 4502637  129 IDRYLAIVHAVFALRArTVTFGVITSIVTWGLAV-LAALP 167
Cdd:cd15137 103 LDRFICIVFPFSGRRL-GLRRAIIVLACIWLIGLlLAVLP 141
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
57-312 6.25e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 38.08  E-value: 6.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   57 MILIKYRRLRIMTNIYLL--NLAISDLLflVTLPFWIHYVRGhnWVFGHGMCKLLS-GFYHTGLYSEIFFIILLTIDRYL 133
Cdd:cd15961  21 VVLIIFQNPSLRAPMFLLigSLALADLL--AGIGLILNFIFA--YLLQSEAAKLVTvGLIVASFSASVCSLLAITVDRYL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  134 AIVHAVFALRARTVTFGVITSIVTWGLAV-LAALPefifyeteelfeETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPL 212
Cdd:cd15961  97 SLYYALTYNSERTVTFTYVMLVLLWGASIcLGLLP------------VMGWNCLADESTCSVVRPLTKNNAAILSVSFLL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  213 L--VMAICYTGIIKTLLRCPSK--------------KKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYqsilfgndcers 276
Cdd:cd15961 165 MfaLMLQLYIQICKIVMRHAHQialqhhflatshyvTTRKGVSTLAIILGTFAACWMPFTLYSLIADY------------ 232
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 4502637  277 KHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYL 312
Cdd:cd15961 233 TYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
64-305 8.45e-03

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 37.68  E-value: 8.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637   64 RLRIMTN-IYLLNLAISDLLFLVTLPF-WIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYL--AIVHAV 139
Cdd:cd15169  30 RLRLTPSlVYALNLGCSDLLLTVSLPLkAVEALASGAWPLPASLCPVFAVAHFAPLYAGGGFLAALSAGRYLgaAFPLGY 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  140 FALRARTVTFGVITSIvtWGLaVLAALPEFIFYETEELFEETLCSALYPEDTV-------YSWRHFHT----LRMTIFCL 208
Cdd:cd15169 110 QAFRRPCYSWGVCAAI--WAL-VLCHLGLVFGLEAPGGWLDHSNTSLGINTPVngspvclEAWDPASAgparFSLSLLLF 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502637  209 VLPLLVMAICYTGIIKTLLR--CPSKKKYKAIRLIFVIMAVFFIFWTPYNVaillSSYQSILFGNDCERSKHLDLVMLVT 286
Cdd:cd15169 187 FLPLAITAFCYVGCLRALARsgLTHRRKLRAAWVAGGALLTLLLCVGPYNA----SNVASFLYPNLGGSWRKLGLITGAW 262
                       250
                ....*....|....*....
gi 4502637  287 EVIayshccMNPVIYAFVG 305
Cdd:cd15169 263 SVV------LNPLVTGYLG 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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