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Conserved domains on  [gi|71040111|ref|NP_002014|]
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fibromodulin precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-354 6.18e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.71  E-value: 6.18e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 105 SRMKYVYFQNNQITSIQEGvFDNATGLLWIALHGNQITSDKvgrKVFSKLRHLERLYLDHNNLTRMPGPLPR--SLRELH 182
Cdd:COG4886 113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELD 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 183 LDHNQISRVPNnALEGLENLTALYLQHNEIQEVGSSMRGLRSLILLDLSYNHLRKVPD--GLPSaLEQLYMEHNNVYTVP 260
Cdd:COG4886 189 LSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPElgNLTN-LEELDLSNNQLTDLP 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 261 DSYfrGAPKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQKIPPVNTNLENLYLQGNRINEFSISSFCTVVDVV 340
Cdd:COG4886 267 PLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344

                       250
                ....*....|....
gi 71040111 341 NFSKLQVLRLDGNE 354
Cdd:COG4886 345 SLLALLTLLLLLNL 358
LRRNT smart00013
Leucine rich repeat N-terminal domain;
75-109 3.18e-07

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.16  E-value: 3.18e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 71040111     75 DCPQECDCPPnfpTAMYCDNRNLKYLPF-VPSRMKY 109
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLdLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-354 6.18e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.71  E-value: 6.18e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 105 SRMKYVYFQNNQITSIQEGvFDNATGLLWIALHGNQITSDKvgrKVFSKLRHLERLYLDHNNLTRMPGPLPR--SLRELH 182
Cdd:COG4886 113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELD 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 183 LDHNQISRVPNnALEGLENLTALYLQHNEIQEVGSSMRGLRSLILLDLSYNHLRKVPD--GLPSaLEQLYMEHNNVYTVP 260
Cdd:COG4886 189 LSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPElgNLTN-LEELDLSNNQLTDLP 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 261 DSYfrGAPKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQKIPPVNTNLENLYLQGNRINEFSISSFCTVVDVV 340
Cdd:COG4886 267 PLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344

                       250
                ....*....|....
gi 71040111 341 NFSKLQVLRLDGNE 354
Cdd:COG4886 345 SLLALLTLLLLLNL 358
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 88-256 2.58e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.13  E-value: 2.58e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111  88 TAMYCDNRNLKYLPFVPS--RMKYVYFQNNQITSIQEgvfdnatgllwialhgnqitsdkvgrkvFSKLRHLERLYLDHN 165
Cdd:cd21340   5 THLYLNDKNITKIDNLSLckNLKVLYLYDNKITKIEN----------------------------LEFLTNLTHLYLQNN 56

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 166 NLTRMPG--PLPRsLRELHLDHNQISRVPNnaLEGLENLTALYLQHNEIQEVGS------SMRGL-RSLILLDLSYNHLR 236
Cdd:cd21340  57 QIEKIENleNLVN-LKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEKltfdprSLAALsNSLRVLNISGNNID 133

                       170       180
                ....*....|....*....|..
gi 71040111 237 KVPD--GLpSALEQLYMEHNNV 256
Cdd:cd21340 134 SLEPlaPL-RNLEQLDASNNQI 154
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
81-309 1.77e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.20  E-value: 1.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111   81 DCPPNFPTAMYCDNRNLKYLP-FVPSRMKYVYFQNNQITSIQEGVFDNATGLlwiALHGNQITSdkvgrkVFSKLRH-LE 158
Cdd:PRK15370 174 DCLKNNKTELRLKILGLTTIPaCIPEQITTLILDNNELKSLPENLQGNIKTL---YANSNQLTS------IPATLPDtIQ 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111  159 RLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENL------------------TALYLQHNEIQEVGSSM- 219
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLsvydnsirtlpahlpsgiTHLNVQSNSLTALPETLp 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111  220 RGLRSLILLDlsyNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYfrgAPKLLYVRLSHNSLTNngLASNTfnSSSLLELD 299
Cdd:PRK15370 325 PGLKTLEAGE---NALTSLPASLPPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTN--LPENL--PAALQIMQ 394

                        250
                 ....*....|
gi 71040111  300 LSYNQLQKIP 309
Cdd:PRK15370 395 ASRNNLVRLP 404
LRR_8 pfam13855
Leucine rich repeat;
176-235 1.47e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 1.47e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71040111   176 RSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEV-GSSMRGLRSLILLDLSYNHL 235
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
75-109 3.18e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.16  E-value: 3.18e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 71040111     75 DCPQECDCPPnfpTAMYCDNRNLKYLPF-VPSRMKY 109
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLdLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 75-105 7.29e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.23  E-value: 7.29e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 71040111    75 DCPQECDCPPnfpTAMYCDNRNLKYLPFVPS 105
Cdd:pfam01462   1 ACPVPCHCSA---TVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-354 6.18e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.71  E-value: 6.18e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 105 SRMKYVYFQNNQITSIQEGvFDNATGLLWIALHGNQITSDKvgrKVFSKLRHLERLYLDHNNLTRMPGPLPR--SLRELH 182
Cdd:COG4886 113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELD 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 183 LDHNQISRVPNnALEGLENLTALYLQHNEIQEVGSSMRGLRSLILLDLSYNHLRKVPD--GLPSaLEQLYMEHNNVYTVP 260
Cdd:COG4886 189 LSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPElgNLTN-LEELDLSNNQLTDLP 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 261 DSYfrGAPKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQKIPPVNTNLENLYLQGNRINEFSISSFCTVVDVV 340
Cdd:COG4886 267 PLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344

                       250
                ....*....|....
gi 71040111 341 NFSKLQVLRLDGNE 354
Cdd:COG4886 345 SLLALLTLLLLLNL 358
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
147-356 1.80e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.56  E-value: 1.80e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 147 GRKVFSKLRHLERLYLDHNNLTRMPGPLPR--SLRELHLDHNQISRVPNnALEGLENLTALYLQHNEIQEVGSSMRGLRS 224
Cdd:COG4886 105 GNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTN 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 225 LILLDLSYNHLRKVPDGL--PSALEQLYMEHNNVYTVPDSyFRGAPKLLYVRLSHNsltnnglasntfnssslleldlsy 302
Cdd:COG4886 184 LKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN------------------------ 238

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 71040111 303 nQLQKIPPV--NTNLENLYLQGNRINEFSISSfctvvdvvNFSKLQVLRLDGNEIK 356
Cdd:COG4886 239 -QLTDLPELgnLTNLEELDLSNNQLTDLPPLA--------NLTNLKTLDLSNNQLT 285
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 88-256 2.58e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.13  E-value: 2.58e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111  88 TAMYCDNRNLKYLPFVPS--RMKYVYFQNNQITSIQEgvfdnatgllwialhgnqitsdkvgrkvFSKLRHLERLYLDHN 165
Cdd:cd21340   5 THLYLNDKNITKIDNLSLckNLKVLYLYDNKITKIEN----------------------------LEFLTNLTHLYLQNN 56

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 166 NLTRMPG--PLPRsLRELHLDHNQISRVPNnaLEGLENLTALYLQHNEIQEVGS------SMRGL-RSLILLDLSYNHLR 236
Cdd:cd21340  57 QIEKIENleNLVN-LKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEKltfdprSLAALsNSLRVLNISGNNID 133

                       170       180
                ....*....|....*....|..
gi 71040111 237 KVPD--GLpSALEQLYMEHNNV 256
Cdd:cd21340 134 SLEPlaPL-RNLEQLDASNNQI 154
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 151-355 9.92e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.21  E-value: 9.92e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 151 FSKLRHLerlYLDHNNLTRMPG-PLPRSLRELHLDHNQISRVPNnaLEGLENLTALYLQHNEIQEVgSSMRGLRSLILLD 229
Cdd:cd21340   1 LKRITHL---YLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 230 LSYNHLRKVpDGL--PSALEQLYMEHNNV-----YTV-PDSYFRGAPKLLYVRLSHNSLTNnglasntfnssslleldls 301
Cdd:cd21340  75 LGGNRISVV-EGLenLTNLEELHIENQRLppgekLTFdPRSLAALSNSLRVLNISGNNIDS------------------- 134

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 71040111 302 YNQLQKIppvnTNLENLYLQGNRINefSISSFCTVVDvvNFSKLQVLRLDGNEI 355
Cdd:cd21340 135 LEPLAPL----RNLEQLDASNNQIS--DLEELLDLLS--SWPSLRELDLTGNPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
81-309 1.77e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.20  E-value: 1.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111   81 DCPPNFPTAMYCDNRNLKYLP-FVPSRMKYVYFQNNQITSIQEGVFDNATGLlwiALHGNQITSdkvgrkVFSKLRH-LE 158
Cdd:PRK15370 174 DCLKNNKTELRLKILGLTTIPaCIPEQITTLILDNNELKSLPENLQGNIKTL---YANSNQLTS------IPATLPDtIQ 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111  159 RLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENL------------------TALYLQHNEIQEVGSSM- 219
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLsvydnsirtlpahlpsgiTHLNVQSNSLTALPETLp 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111  220 RGLRSLILLDlsyNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYfrgAPKLLYVRLSHNSLTNngLASNTfnSSSLLELD 299
Cdd:PRK15370 325 PGLKTLEAGE---NALTSLPASLPPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTN--LPENL--PAALQIMQ 394

                        250
                 ....*....|
gi 71040111  300 LSYNQLQKIP 309
Cdd:PRK15370 395 ASRNNLVRLP 404
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-330 2.09e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 2.09e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111  91 YCDNRNLKYLPFVPSRM---KYVYFQNNQITSIQEgVFDNATGLLWIALHGNQITSDKvgrKVFSKLRHLERLYLDHNNL 167
Cdd:COG4886 142 DLSNNQLTDLPEPLGNLtnlKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP---EPLGNLTNLEELDLSGNQL 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 168 TRMPGPLPR--SLRELHLDHNQISRVP--------------NNALEG------LENLTALYLQHNEIQEVgssmrGLRSL 225
Cdd:COG4886 218 TDLPEPLANltNLETLDLSNNQLTDLPelgnltnleeldlsNNQLTDlpplanLTNLKTLDLSNNQLTDL-----KLKEL 292

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 226 ILLDLSYNHLRKV--PDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYN 303
Cdd:COG4886 293 ELLLGLNSLLLLLllLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372

                       250       260
                ....*....|....*....|....*..
gi 71040111 304 QLQKIPPVNTNLENLYLQGNRINEFSI 330
Cdd:COG4886 373 GLLEATLLTLALLLLTLLLLLLTTTAG 399
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
84-281 3.17e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.80  E-value: 3.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111   84 PNFPTAMYCDNRNLKYLP-FVPSRMKYVYFQNNQITSIQEGVFDnatGLLWIALHGNQITSdkVGRKVFSKLRHLerlYL 162
Cdd:PRK15370 240 PDTIQEMELSINRITELPeRLPSALQSLDLFHNKISCLPENLPE---ELRYLSVYDNSIRT--LPAHLPSGITHL---NV 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111  163 DHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTalyLQHNEIQEVGSSMRglRSLILLDLSYNHLRKVPDGL 242
Cdd:PRK15370 312 QSNSLTALPETLPPGLKTLEAGENALTSLPASLPPELQVLD---VSKNQITVLPETLP--PTITTLDVSRNALTNLPENL 386

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 71040111  243 PSALEQLYMEHNNVYTVPDS--YFRG-APKLLYVRLSHNSLT 281
Cdd:PRK15370 387 PAALQIMQASRNNLVRLPESlpHFRGeGPQPTRIIVEYNPFS 428
LRR_8 pfam13855
Leucine rich repeat;
176-235 1.47e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 1.47e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71040111   176 RSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEV-GSSMRGLRSLILLDLSYNHL 235
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
81-260 4.77e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 61.33  E-value: 4.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111   81 DCPPNFPTAMYCDNRNLKYLPFVPSRMKYVYFQNNQITS--------IQEGVFDN--------ATGLLWIALHGNQITSD 144
Cdd:PRK15387 218 DCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSlpvlppglLELSIFSNplthlpalPSGLCKLWIFGNQLTSL 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111  145 KVGRKVFSKL--------------RHLERLYLDHNNLTRMPgPLPRSLRELHLDHNQISRVPNNALEglenLTALYLQHN 210
Cdd:PRK15387 298 PVLPPGLQELsvsdnqlaslpalpSELCKLWAYNNQLTSLP-TLPSGLQELSVSDNQLASLPTLPSE----LYKLWAYNN 372

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 71040111  211 EIQEVGSSMRGLRSLIlldLSYNHLRKVPdGLPSALEQLYMEHNNVYTVP 260
Cdd:PRK15387 373 RLTSLPALPSGLKELI---VSGNRLTSLP-VLPSELKELMVSGNRLTSLP 418
LRR_8 pfam13855
Leucine rich repeat;
155-212 1.50e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 1.50e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71040111   155 RHLERLYLDHNNLTRMPGPLPR---SLRELHLDHNQISRVPNNALEGLENLTALYLQHNEI 212
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKglsNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 110-239 6.75e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 6.75e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 110 VYFQNNQITSIqEGvFDNATGLLWIALHGNQItsdkvgRKV--FSKLRHLERLYLDHNNL---------TRMPGPLPRSL 178
Cdd:cd21340  51 LYLQNNQIEKI-EN-LENLVNLKKLYLGGNRI------SVVegLENLTNLEELHIENQRLppgekltfdPRSLAALSNSL 122

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71040111 179 RELHLDHNQISRVpnNALEGLENLTALYLQHNEIQ---EVGSSMRGLRSLILLDLSYNHLRKVP 239
Cdd:cd21340 123 RVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 136-359 7.34e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.59  E-value: 7.34e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 136 LHGNQITSDKVGRkVFSKLRHLERLYLDHNNLTRMPGPL-------PRSLRELHLDHNQISRVPNN---ALEGLEN---L 202
Cdd:cd00116   5 LKGELLKTERATE-LLPKLLCLQVLRLEGNTLGEEAAKAlasalrpQPSLKELCLSLNETGRIPRGlqsLLQGLTKgcgL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 203 TALYLQHNEIQEVGS----SMRGLRSLILLDLSYN-----HLRKVPDGL---PSALEQLYMEHNNVYTVP----DSYFRG 266
Cdd:cd00116  84 QELDLSDNALGPDGCgvleSLLRSSSLQELKLNNNglgdrGLRLLAKGLkdlPPALEKLVLGRNRLEGAScealAKALRA 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 267 APKLLYVRLSHNSLTNNG------------------LASNTFNSSSLLeldlsynQLQKIPPVNTNLENLYLQGNRINEF 328
Cdd:cd00116 164 NRDLKELNLANNGIGDAGiralaeglkancnlevldLNNNGLTDEGAS-------ALAETLASLKSLEVLNLGDNNLTDA 236

                       250       260       270
                ....*....|....*....|....*....|.
gi 71040111 329 SISSFCTVVDVVNfSKLQVLRLDGNEIKRSA 359
Cdd:cd00116 237 GAAALASALLSPN-ISLLTLSLSCNDITDDG 266
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-318 1.21e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 1.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 105 SRMKYVYFQNNQITSIQEGvFDNATGLLWIALHGNQITSdkvgRKVFSKLRHLERLYLDHNNLTRMPGPLP-RSLRELHL 183
Cdd:COG4886 205 TNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTD----LPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDL 279

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 184 DHNQISRVPNNALEGLENLTALYLQHNEIQEVGSSMRGLRSLILLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSY 263
Cdd:COG4886 280 SNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLL 359

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 71040111 264 FRGAPKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQKIPPVNTNLENL 318
Cdd:COG4886 360 SLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
83-254 4.63e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.09  E-value: 4.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111   83 PPNFPTAM-YCD--NRNLKYLP-FVPSRMKYVYFQNNQITSIQEGVfdnATGLLWIALHGNQITSDKVgrkvfSKLRHLE 158
Cdd:PRK15370 278 PENLPEELrYLSvyDNSIRTLPaHLPSGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPA-----SLPPELQ 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111  159 RLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPnnaleglENLTAlylqhneiqevgssmrglrSLILLDLSYNHLRKV 238
Cdd:PRK15370 350 VLDVSKNQITVLPETLPPTITTLDVSRNALTNLP-------ENLPA-------------------ALQIMQASRNNLVRL 403

                        170       180
                 ....*....|....*....|..
gi 71040111  239 PDGLPSALEQ------LYMEHN 254
Cdd:PRK15370 404 PESLPHFRGEgpqptrIIVEYN 425
LRR_8 pfam13855
Leucine rich repeat;
105-167 2.04e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.04e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71040111   105 SRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSdkVGRKVFSKLRHLERLYLDHNNL 167
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
75-109 3.18e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.16  E-value: 3.18e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 71040111     75 DCPQECDCPPnfpTAMYCDNRNLKYLPF-VPSRMKY 109
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLdLPPDTTL 33
LRR_8 pfam13855
Leucine rich repeat;
201-256 3.60e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 3.60e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71040111   201 NLTALYLQHNEIQEVGSSM-RGLRSLILLDLSYNHLRKVP----DGLPSaLEQLYMEHNNV 256
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSpgafSGLPS-LRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 110-373 2.78e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.02  E-value: 2.78e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 110 VYFQNNQITSIQEGVFDNA----TGLLWIALHGNQITSDKVGRkVFSKLRHLERLY-LD-HNNLTRMPG--------PLP 175
Cdd:COG5238 185 VYLGCNQIGDEGIEELAEAltqnTTVTTLWLKRNPIGDEGAEI-LAEALKGNKSLTtLDlSNNQIGDEGvialaealKNN 263

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 176 RSLRELHLDHNQIS----RVPNNALEGLENLTALYLQHNEIQEVGS-----SMRGLRSLILLDLSYNHLRKV-PDGLPSA 245
Cdd:COG5238 264 TTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIGDEGAialaeGLQGNKTLHTLNLAYNGIGAQgAIALAKA 343

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111 246 LEQLYMEHNnvytvpdsyfrgapkllyVRLSHNSLTNNGLASntfnssslleldlsynqLQKIPPVNTNLENLYLQGNRI 325
Cdd:COG5238 344 LQENTTLHS------------------LDLSDNQIGDEGAIA-----------------LAKYLEGNTTLRELNLGKNNI 388

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 71040111 326 NEfsiSSFCTVVDVVNFSKLQVLRLDGNEIKRSAMPADAPLCLRLASL 373
Cdd:COG5238 389 GK---QGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLERIKSV 433
LRR_8 pfam13855
Leucine rich repeat;
129-188 4.06e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 4.06e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71040111   129 TGLLWIALHGNQITSdkVGRKVFSKLRHLERLYLDHNNLTRMPG----PLPrSLRELHLDHNQI 188
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPgafsGLP-SLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 105-281 5.17e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 5.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111  105 SRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSdKVGRKVfSKLRHLERLYLDHNNLTrmpGPLPRSLREL--- 181
Cdd:PLN00113 164 SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVG-QIPREL-GQMKSLKWIYLGYNNLS---GEIPYEIGGLtsl 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111  182 -HLD---HNQISRVPNnALEGLENLTALYLQHNEIQ-EVGSSMRGLRSLILLDLSYNHLR-KVPDGLPS--ALEQLYMEH 253
Cdd:PLN00113 239 nHLDlvyNNLTGPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQlqNLEILHLFS 317

                        170       180
                 ....*....|....*....|....*....
gi 71040111  254 NNVY-TVPDSyFRGAPKLLYVRLSHNSLT 281
Cdd:PLN00113 318 NNFTgKIPVA-LTSLPRLQVLQLWSNKFS 345
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 75-105 7.29e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.23  E-value: 7.29e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 71040111    75 DCPQECDCPPnfpTAMYCDNRNLKYLPFVPS 105
Cdd:pfam01462   1 ACPVPCHCSA---TVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 151-257 5.02e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 5.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71040111  151 FSKLRHLERLYLDHNnltRMPGPLPRSLR------ELHLDHNQISRVPNNALEGLENLTALYLQHNEIQ-EVGSSMRGLR 223
Cdd:PLN00113 471 SFGSKRLENLDLSRN---QFSGAVPRKLGslselmQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMP 547

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 71040111  224 SLILLDLSYNHLR-KVPDGLPS--ALEQLYMEHNNVY 257
Cdd:PLN00113 548 VLSQLDLSQNQLSgEIPKNLGNveSLVQVNISHNHLH 584
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 177-210 2.15e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 2.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 71040111   177 SLRELHLDHNQISRVPNnaLEGLENLTALYLQHN 210
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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