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Conserved domains on  [gi|4503911|ref|NP_002036|]
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neuromodulin isoform 2 [Homo sapiens]

Protein Classification

IQCD and Neuromodulin domain-containing protein( domain architecture ID 12107677)

protein containing domains Neuromodulin_N, IQCD, and Neuromodulin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Neuromodulin pfam06614
Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) ...
 67-238 2.99e-42

Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) sequences and is found in conjunction with pfam00612. GAP-43 is a neuronal calmodulin-binding phosphoprotein that is concentrated in growth cones and pre-synaptic terminals.


:

Pssm-ID: 461961 [Multi-domain]  Cd Length: 175  Bit Score: 141.45  E-value: 2.99e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911     67 NKKDEAPVADGVEKK-GEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG--DAATEQAAPQAPASSEEKAGSAETESA 143
Cdd:pfam06614   1 KKKDEAPAADGVEKKeSEAPTATEAAPAAGAKPDEAGKAGDTPSEEKKGEGaaDAASEQAAPQAPASSEEKAGSAETESA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911    144 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
Cdd:pfam06614  81 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETAESSQAEEKTEAVDETKPKESARQ 160

                         170
                  ....*....|....*
gi 4503911    224 DEGKEEEPEADQEHA 238
Cdd:pfam06614 161 DEGKEEESEADQEHA 175
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 30-52 2.26e-05

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


:

Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 40.00  E-value: 2.26e-05
                           10        20
                   ....*....|....*....|...
gi 4503911      30 KAHKAATKIQASFRGHITRKKLK 52
Cdd:smart00015   1 RLTRAAIIIQAAWRGYLARKRYK 23
Neuromodulin_N pfam10580
Gap junction protein N-terminal region;
2-31 3.00e-03

Gap junction protein N-terminal region;


:

Pssm-ID: 431370 [Multi-domain]  Cd Length: 31  Bit Score: 34.57  E-value: 3.00e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 4503911      2 LCCMRRTKQVEKNDD-DQKIEQDGIKPEDKA 31
Cdd:pfam10580   1 LCCVRASAKVEKNDEaDQKIEQDGNKPEDKA 31
 
Name Accession Description Interval E-value
Neuromodulin pfam06614
Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) ...
 67-238 2.99e-42

Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) sequences and is found in conjunction with pfam00612. GAP-43 is a neuronal calmodulin-binding phosphoprotein that is concentrated in growth cones and pre-synaptic terminals.


Pssm-ID: 461961 [Multi-domain]  Cd Length: 175  Bit Score: 141.45  E-value: 2.99e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911     67 NKKDEAPVADGVEKK-GEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG--DAATEQAAPQAPASSEEKAGSAETESA 143
Cdd:pfam06614   1 KKKDEAPAADGVEKKeSEAPTATEAAPAAGAKPDEAGKAGDTPSEEKKGEGaaDAASEQAAPQAPASSEEKAGSAETESA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911    144 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
Cdd:pfam06614  81 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETAESSQAEEKTEAVDETKPKESARQ 160

                         170
                  ....*....|....*
gi 4503911    224 DEGKEEEPEADQEHA 238
Cdd:pfam06614 161 DEGKEEESEADQEHA 175
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 30-52 2.26e-05

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 40.00  E-value: 2.26e-05
                           10        20
                   ....*....|....*....|...
gi 4503911      30 KAHKAATKIQASFRGHITRKKLK 52
Cdd:smart00015   1 RLTRAAIIIQAAWRGYLARKRYK 23
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 32-52 4.69e-05

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 39.22  E-value: 4.69e-05
                          10        20
                  ....*....|....*....|.
gi 4503911     32 HKAATKIQASFRGHITRKKLK 52
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRYK 21
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 28-56 1.47e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 38.29  E-value: 1.47e-04
                        10        20
                ....*....|....*....|....*....
gi 4503911   28 EDKAHKAATKIQASFRGHITRKKLKGEKK 56
Cdd:cd23767   5 LQRMNRAATLIQALWRGYKVRKELKKKKK 33
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 53-166 9.59e-04

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 39.96  E-value: 9.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911    53 GEKKDDVQAAEAEANKKDE--APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS 130
Cdd:PRK13108 310 SAASAVGPVGPGEPNQPDDvaEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQV 389

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 4503911   131 SEEKAGSAETESATKASTDnsPSSKAEDAPAKEEPK 166
Cdd:PRK13108 390 DAEAASAAPEEPAALASEA--HDETEPEVPEKAAPI 423
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 51-236 1.60e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.59  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911      51 LKGEKKDDvQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEqaaPQAPAS 130
Cdd:TIGR00927  685 IPAERKGE-QEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHE---VETEGD 760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911     131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
Cdd:TIGR00927  761 RKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAE 840

                          170       180       190
                   ....*....|....*....|....*....|...
gi 4503911     211 AVDETKPKESARQDEG-------KEEEPEADQE 236
Cdd:TIGR00927  841 NQGEAKQDEKGVDGGGgsdggdsEEEEEEEEEE 873
Neuromodulin_N pfam10580
Gap junction protein N-terminal region;
2-31 3.00e-03

Gap junction protein N-terminal region;


Pssm-ID: 431370 [Multi-domain]  Cd Length: 31  Bit Score: 34.57  E-value: 3.00e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 4503911      2 LCCMRRTKQVEKNDD-DQKIEQDGIKPEDKA 31
Cdd:pfam10580   1 LCCVRASAKVEKNDEaDQKIEQDGNKPEDKA 31
 
Name Accession Description Interval E-value
Neuromodulin pfam06614
Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) ...
 67-238 2.99e-42

Neuromodulin; This family consists of several neuromodulin (Axonal membrane protein GAP-43) sequences and is found in conjunction with pfam00612. GAP-43 is a neuronal calmodulin-binding phosphoprotein that is concentrated in growth cones and pre-synaptic terminals.


Pssm-ID: 461961 [Multi-domain]  Cd Length: 175  Bit Score: 141.45  E-value: 2.99e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911     67 NKKDEAPVADGVEKK-GEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG--DAATEQAAPQAPASSEEKAGSAETESA 143
Cdd:pfam06614   1 KKKDEAPAADGVEKKeSEAPTATEAAPAAGAKPDEAGKAGDTPSEEKKGEGaaDAASEQAAPQAPASSEEKAGSAETESA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911    144 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 223
Cdd:pfam06614  81 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETAESSQAEEKTEAVDETKPKESARQ 160

                         170
                  ....*....|....*
gi 4503911    224 DEGKEEEPEADQEHA 238
Cdd:pfam06614 161 DEGKEEESEADQEHA 175
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
 30-52 2.26e-05

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 40.00  E-value: 2.26e-05
                           10        20
                   ....*....|....*....|...
gi 4503911      30 KAHKAATKIQASFRGHITRKKLK 52
Cdd:smart00015   1 RLTRAAIIIQAAWRGYLARKRYK 23
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
 32-52 4.69e-05

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 39.22  E-value: 4.69e-05
                          10        20
                  ....*....|....*....|.
gi 4503911     32 HKAATKIQASFRGHITRKKLK 52
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRYK 21
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 28-56 1.47e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 38.29  E-value: 1.47e-04
                        10        20
                ....*....|....*....|....*....
gi 4503911   28 EDKAHKAATKIQASFRGHITRKKLKGEKK 56
Cdd:cd23767   5 LQRMNRAATLIQALWRGYKVRKELKKKKK 33
Adgb_C_mid-like cd22307
C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted ...
 14-52 3.15e-04

C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif; Androglobin (Adgb, also known as Calpain-7-like protein, CAPN7L) is a large multidomain protein consisting of an N-terminal peptidase C2 family calpain-like domain, an IQ calmodulin-binding motif, and an internal, circularly permuted globin domain. The canonical secondary structure of hemoglobins is an 3-over-3 alpha-helical sandwich structure, where the eight alpha-helical segments are conventionally labeled, A-H, according to their sequential order; Adgbs differ from this in having helices C-H followed by A-B. Adgbs and other phylogenetically ancient globins, such as neuroglobins and globin X, form hexacoordinated heme iron complexes. Globins contain various highly conserved residues of the heme pocket: including a Phe in the interhelical position CD1 (Phe CD1, first position in the loop between the helices C and D) that is packed against the heme, a His at the 7th position of the E-helix (His E7) that binds the heme iron distally, and a His at the 8th position of the F-helix (His F8) that binds the heme iron proximally. Unlike other hexacoordinated globins, Adgbs have an E7 Gln; their hexacoordination scheme is [Gln]-Fe-[His]. In mammals, Adgb is mainly expressed in the testes and may play an important role in spermatogenesis. Arthropod Adgbs have degenerate globin domains (DOI:10.3389/fgene.2020.00858). This model spans the permuted globin domain, the IQ motif, and a conserved region of about 200 amino acid residues located C-terminal to the globin domain; it does not include the N-terminal protease domain or the large uncharacterized C-terminal domain of approximately 500 residues.


Pssm-ID: 412094  Cd Length: 416  Bit Score: 41.38  E-value: 3.15e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 4503911   14 NDDDQKIEQDGI--KPEDKAHKAATKIQASFRGHITRKKLK 52
Cdd:cd22307 127 REIVEPDECDCRtrEPTIEEHEAATKIQAFFRGTLVRKLLK 167
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 53-166 9.59e-04

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 39.96  E-value: 9.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911    53 GEKKDDVQAAEAEANKKDE--APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS 130
Cdd:PRK13108 310 SAASAVGPVGPGEPNQPDDvaEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQV 389

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 4503911   131 SEEKAGSAETESATKASTDnsPSSKAEDAPAKEEPK 166
Cdd:PRK13108 390 DAEAASAAPEEPAALASEA--HDETEPEVPEKAAPI 423
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 51-236 1.60e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.59  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911      51 LKGEKKDDvQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEqaaPQAPAS 130
Cdd:TIGR00927  685 IPAERKGE-QEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHE---VETEGD 760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911     131 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 210
Cdd:TIGR00927  761 RKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAE 840

                          170       180       190
                   ....*....|....*....|....*....|...
gi 4503911     211 AVDETKPKESARQDEG-------KEEEPEADQE 236
Cdd:TIGR00927  841 NQGEAKQDEKGVDGGGgsdggdsEEEEEEEEEE 873
Neuromodulin_N pfam10580
Gap junction protein N-terminal region;
2-31 3.00e-03

Gap junction protein N-terminal region;


Pssm-ID: 431370 [Multi-domain]  Cd Length: 31  Bit Score: 34.57  E-value: 3.00e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 4503911      2 LCCMRRTKQVEKNDD-DQKIEQDGIKPEDKA 31
Cdd:pfam10580   1 LCCVRASAKVEKNDEaDQKIEQDGNKPEDKA 31
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 56-236 4.56e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 38.05  E-value: 4.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911      56 KDDVQAAEAEANKKDE--APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEeKKGEGDAATEQAAPQAPASSEE 133
Cdd:TIGR00927  632 KGDVAEAEHTGERTGEegERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAE-RKGEQEGEGEIEAKEADHKGET 710

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911     134 KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESS---QAEENIE 210
Cdd:TIGR00927  711 EAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEgeiQAGEDGE 790

                          170       180
                   ....*....|....*....|....*.
gi 4503911     211 AVDETKPKESARQDEGKEEEPEADQE 236
Cdd:TIGR00927  791 MKGDEGAEGKVEHEGETEAGEKDEHE 816
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 54-232 5.26e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 37.67  E-value: 5.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911      54 EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGK-----AGETPSEEKKGEGDAATEQAAPQAP 128
Cdd:TIGR00927  639 EHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAErkgeqEGEGEIEAKEADHKGETEAEEVEHE 718

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911     129 ASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQpPTETGESSQAEEN 208
Cdd:TIGR00927  719 GETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQ-AGEDGEMKGDEGA 797

                          170       180
                   ....*....|....*....|....
gi 4503911     209 IEAVDETKPKESARQDEGKEEEPE 232
Cdd:TIGR00927  798 EGKVEHEGETEAGEKDEHEGQSET 821
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 61-195 8.82e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 36.88  E-value: 8.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911    61 AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA------PQAPASSEEK 134
Cdd:PRK13108 304 AAAAVASAASAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQVADRDGESTPAVEETSeadierEQPGDLAGQA 383

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4503911   135 AGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQP 195
Cdd:PRK13108 384 PAAHQVDAEAASAAPEEPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPGDDPAEP 444
PTZ00121 PTZ00121
MAEBL; Provisional
 6-238 9.52e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 37.04  E-value: 9.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911      6 RRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEaEANKKDEAPVADGVEKKGEGT 85
Cdd:PTZ00121 1236 KKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKAD-EAKKAEEKKKADEAKKKAEEA 1314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503911     86 TTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT--EQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKE 163
Cdd:PTZ00121 1315 KKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKaeAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAD 1394

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4503911    164 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
Cdd:PTZ00121 1395 EAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEA 1469
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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