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Conserved domains on  [gi|4503929|ref|NP_002042|]
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trans-acting T-cell-specific transcription factor GATA-3 isoform 2 [Homo sapiens]

Protein Classification

trans-acting T-cell-specific transcription factor GATA-3( domain architecture ID 13285435)

trans-acting T-cell-specific transcription factor GATA-3 acts as a transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes

Gene Symbol:  GATA3
Gene Ontology:  GO:0003700|GO:0008270|GO:0043565|GO:0050852
PubMed:  31574210

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 316-366 1.75e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.65  E-value: 1.75e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 4503929  316 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNINRPLTMKKEG-IQTRNR 366
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 262-312 2.84e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.18  E-value: 2.84e-18
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 4503929  262 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 312
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
PHA03377 super family cl31823
EBNA-3C; Provisional
 1-244 6.93e-04

EBNA-3C; Provisional


The actual alignment was detected with superfamily member PHA03377:

Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 42.35  E-value: 6.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929      1 MEVTADQPRWVSHHHPavLNGQHPDTHHPGLSHSYMDAaqyplPEEVDVLFNIDGQGNHVPPYYG-NSVRATVQRYP--- 76
Cdd:PHA03377  693 VDAGRAQPSEESHLSS--MSPTQPISHEEQPRYEDPDD-----PLDLSLHPDQAPPPSHQAPYSGhEEPQAQQAPYPgyw 765

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929     77 --------------PTHHGSQVCRPPLLHGslPWLDGGKALGSHHTASPWNLSPfsktsIHHGSPGPLSVYPPASSSSLS 142
Cdd:PHA03377  766 eprppqapylgyqePQAQGVQVSSYPGYAG--PWGLRAQHPRYRHSWAYWSQYP-----GHGHPQGPWAPRPPHLPPQWD 838

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929    143 G--GHASPHLFTFPPTPPKDVSPDPSLS---------TPGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMtALGGA 211
Cdd:PHA03377  839 GsaGHGQDQVSQFPHLQSETGPPRLQLSqvpqlpysqTLVSSSAPSWSSPQPRAPIRPIPTRFPPPPMPLQDSM-AVGCD 917

                         250       260       270
                  ....*....|....*....|....*....|...
gi 4503929    212 SSSTHHPITtypPYVPEYSSGLFPPSSLLGGSP 244
Cdd:PHA03377  918 SSGTACPSM---PFASDYSQGAFTPLDINAQTP 947
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 316-366 1.75e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.65  E-value: 1.75e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 4503929  316 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNINRPLTMKKEG-IQTRNR 366
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 262-312 2.84e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.18  E-value: 2.84e-18
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 4503929  262 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 312
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
312-361 2.71e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 75.53  E-value: 2.71e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 4503929     312 RAGTSCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNI-NRPLTMKKEGI 361
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
260-306 9.14e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 68.21  E-value: 9.14e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 4503929     260 GRECVNCGATSTPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 306
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 317-348 5.06e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 5.06e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 4503929    317 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLH 348
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKK 33
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 263-297 5.69e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 5.69e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 4503929    263 CVNCGATSTPLWRRDGTGHY-LCNACGLYHKMNGQN 297
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
208-341 7.33e-08

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 54.49  E-value: 7.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929  208 LGGASSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSPtgfgcksRPKARSSTGRECVNCGATSTPLWRRD-----GTGHY 282
Cdd:COG5641 113 SNAASPSTNYTDESNQQFSSYNTTLNPGGTSSLNPNN-------NQSDNSNQPHVCSNCKTTSTPLWRRAssessLPGNN 185

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929  283 LCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTT-TTLWRRNANGDPVCNAC 341
Cdd:COG5641 186 LCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTESIGNSSASKLTK 245
PHA03377 PHA03377
EBNA-3C; Provisional
 1-244 6.93e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 42.35  E-value: 6.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929      1 MEVTADQPRWVSHHHPavLNGQHPDTHHPGLSHSYMDAaqyplPEEVDVLFNIDGQGNHVPPYYG-NSVRATVQRYP--- 76
Cdd:PHA03377  693 VDAGRAQPSEESHLSS--MSPTQPISHEEQPRYEDPDD-----PLDLSLHPDQAPPPSHQAPYSGhEEPQAQQAPYPgyw 765

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929     77 --------------PTHHGSQVCRPPLLHGslPWLDGGKALGSHHTASPWNLSPfsktsIHHGSPGPLSVYPPASSSSLS 142
Cdd:PHA03377  766 eprppqapylgyqePQAQGVQVSSYPGYAG--PWGLRAQHPRYRHSWAYWSQYP-----GHGHPQGPWAPRPPHLPPQWD 838

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929    143 G--GHASPHLFTFPPTPPKDVSPDPSLS---------TPGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMtALGGA 211
Cdd:PHA03377  839 GsaGHGQDQVSQFPHLQSETGPPRLQLSqvpqlpysqTLVSSSAPSWSSPQPRAPIRPIPTRFPPPPMPLQDSM-AVGCD 917

                         250       260       270
                  ....*....|....*....|....*....|...
gi 4503929    212 SSSTHHPITtypPYVPEYSSGLFPPSSLLGGSP 244
Cdd:PHA03377  918 SSGTACPSM---PFASDYSQGAFTPLDINAQTP 947
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 76-224 8.54e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.59  E-value: 8.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929     76 PPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPP 155
Cdd:pfam03154 257 PPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQS 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929    156 TPPKDVSP-----------DPSLSTPGSAGSARQDEKECLKYQVPLPDSMklesSHSRGSMTALGGASS-STHHPITTYP 223
Cdd:pfam03154 337 QQPPREQPlppaplsmphiKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQM----NSNLPPPPALKPLSSlSTHHPPSAHP 412


                  .
gi 4503929    224 P 224
Cdd:pfam03154 413 P 413
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 316-366 1.75e-19

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 81.65  E-value: 1.75e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 4503929  316 SCANCQTTTTTLWRRNAN-GDPVCNACGLYYKLHNINRPLTMKKEG-IQTRNR 366
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNR 53
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 262-312 2.84e-18

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 78.18  E-value: 2.84e-18
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 4503929  262 ECVNCGATSTPLWRRDG-TGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 312
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
312-361 2.71e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 75.53  E-value: 2.71e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 4503929     312 RAGTSCANCQTTTTTLWRRNANGD-PVCNACGLYYKLHNI-NRPLTMKKEGI 361
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
260-306 9.14e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 68.21  E-value: 9.14e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 4503929     260 GRECVNCGATSTPLWRRDGTGH-YLCNACGLYHKMNGQ-NRPLIKPKRR 306
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 317-348 5.06e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 5.06e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 4503929    317 CANCQTTTTTLWRRNANGDP-VCNACGLYYKLH 348
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKK 33
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 263-297 5.69e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 5.69e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 4503929    263 CVNCGATSTPLWRRDGTGHY-LCNACGLYHKMNGQN 297
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
208-341 7.33e-08

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 54.49  E-value: 7.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929  208 LGGASSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSPtgfgcksRPKARSSTGRECVNCGATSTPLWRRD-----GTGHY 282
Cdd:COG5641 113 SNAASPSTNYTDESNQQFSSYNTTLNPGGTSSLNPNN-------NQSDNSNQPHVCSNCKTTSTPLWRRAssessLPGNN 185

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929  283 LCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTT-TTLWRRNANGDPVCNAC 341
Cdd:COG5641 186 LCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSNGeNANTESIGNSSASKLTK 245
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
265-429 1.99e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 52.95  E-value: 1.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929  265 NCGATSTPLWRR-DGTGHYLCNACGLYHKMNGQNRPLikPKRRLSAARRAGTSCANCQTTTTTLWRRNANGdpvCNACGL 343
Cdd:COG5641 303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKILSPPTT---SNSPGA 377

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929  344 YYKLHNINRPLTMKKEGIQTRnrkmsskskkckkvhdsledfPKNSSFNPAALSRHMSSLSHISPFShSSHMLTTPTPMH 423
Cdd:COG5641 378 QVKLPNQTRSTGATKKKITRR---------------------RMNSGKIPALSSSMKNPVPKEFSPL-IPQSTESETPSQ 435


                ....*.
gi 4503929  424 PPSSLS 429
Cdd:COG5641 436 SKSSLT 441
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
316-366 3.06e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 52.57  E-value: 3.06e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4503929  316 SCANCQTTTTTLWRR-----NANGDPVCNACGLYYKLHNINR-PLTMKKEGIQTRNR 366
Cdd:COG5641 160 VCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRSS 216
PHA03377 PHA03377
EBNA-3C; Provisional
 1-244 6.93e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 42.35  E-value: 6.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929      1 MEVTADQPRWVSHHHPavLNGQHPDTHHPGLSHSYMDAaqyplPEEVDVLFNIDGQGNHVPPYYG-NSVRATVQRYP--- 76
Cdd:PHA03377  693 VDAGRAQPSEESHLSS--MSPTQPISHEEQPRYEDPDD-----PLDLSLHPDQAPPPSHQAPYSGhEEPQAQQAPYPgyw 765

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929     77 --------------PTHHGSQVCRPPLLHGslPWLDGGKALGSHHTASPWNLSPfsktsIHHGSPGPLSVYPPASSSSLS 142
Cdd:PHA03377  766 eprppqapylgyqePQAQGVQVSSYPGYAG--PWGLRAQHPRYRHSWAYWSQYP-----GHGHPQGPWAPRPPHLPPQWD 838

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929    143 G--GHASPHLFTFPPTPPKDVSPDPSLS---------TPGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMtALGGA 211
Cdd:PHA03377  839 GsaGHGQDQVSQFPHLQSETGPPRLQLSqvpqlpysqTLVSSSAPSWSSPQPRAPIRPIPTRFPPPPMPLQDSM-AVGCD 917

                         250       260       270
                  ....*....|....*....|....*....|...
gi 4503929    212 SSSTHHPITtypPYVPEYSSGLFPPSSLLGGSP 244
Cdd:PHA03377  918 SSGTACPSM---PFASDYSQGAFTPLDINAQTP 947
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 76-224 8.54e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.59  E-value: 8.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929     76 PPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPP 155
Cdd:pfam03154 257 PPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQS 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503929    156 TPPKDVSP-----------DPSLSTPGSAGSARQDEKECLKYQVPLPDSMklesSHSRGSMTALGGASS-STHHPITTYP 223
Cdd:pfam03154 337 QQPPREQPlppaplsmphiKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQM----NSNLPPPPALKPLSSlSTHHPPSAHP 412


                  .
gi 4503929    224 P 224
Cdd:pfam03154 413 P 413
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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