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Conserved domains on  [gi|94721241|ref|NP_002152|]
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isoleucine--tRNA ligase, cytoplasmic isoform 1 [Homo sapiens]

Protein Classification

aminoacyl-tRNA ligase family protein( domain architecture ID 1001906)

aminoacyl-tRNA ligase family protein catalyzes the attachment of an amino acid to its corresponding transfer RNA (tRNA) which is essential for protein synthesis; similar to isoleucine--tRNA ligase, which catalyzes the attachment of isoleucine to tRNA(Ile)

EC:  6.1.1.-
Gene Ontology:  GO:0005524|GO:0004812
PubMed:  7708661

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02882 super family cl33590
aminoacyl-tRNA ligase
6-1071 0e+00

aminoacyl-tRNA ligase


The actual alignment was detected with superfamily member PLN02882:

Pssm-ID: 215477 [Multi-domain]  Cd Length: 1159  Bit Score: 1652.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     6 PENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:PLN02882    5 GKDFSFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGW 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    86 DCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQ 165
Cdd:PLN02882   85 DCHGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQ 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   166 LYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPL-EEDETVSLVAWTTTPWTLPSNLAVCVNPEMQY 244
Cdd:PLN02882  165 LFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIvGDPDNASFVAWTTTPWTLPSNLALCVNPNFTY 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   245 VKIKDVARGRLLILMEARLSALY-------------KLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENgAFTVLVDN 311
Cdd:PLN02882  245 VKVRNKYTGKVYIVAESRLSALPtakpkskkgskpeNAAEGYEVLAKVPGSSLVGKKYEPLFDYFSEFSDT-AFRVVADD 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   312 YVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVAT 391
Cdd:PLN02882  324 YVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKGGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSG 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   392 TFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWV 471
Cdd:PLN02882  404 SITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGTPLPIWI 483
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   472 SDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGK--GSLHRISEVFDCWFESGSMPYAQVHYPFENKREFE 549
Cdd:PLN02882  484 SDDGEEVVVIGSIAELEKLSGVKVTDLHRHFIDHITIPSSRGPefGVLRRVDDVFDCWFESGSMPYAYIHYPFENKELFE 563
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   550 DAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLIN 629
Cdd:PLN02882  564 KNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLIN 643
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   630 SPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFL-YNENTVRESPNITDRWILSFMQSLIGFFE 708
Cdd:PLN02882  644 SPVVRAEPLRFKEEGVFGVVKDVFLPWYNAYRFLVQNAKRLEVEGGAPFVpLDLAKLQNSANVLDRWINSATQSLVKFVR 723
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   709 TEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNL-KVL 787
Cdd:PLN02882  724 EEMGAYRLYTVVPYLVKFIDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLrKVL 803
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   788 idPVSVQdkdtlSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIK-SL 866
Cdd:PLN02882  804 --PGSEE-----SIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAEFLDDITgKL 876
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   867 EKYIIEELNVRKVTLSTDKNKYgIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIR 946
Cdd:PLN02882  877 KEYVLEELNVRSLVPCNDPLKY-ASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDILEFEKAGEVTIAGHTLKAGDIK 955
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   947 LMYTFDQATG-GTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYK--AKSEGTYLN 1023
Cdd:PLN02882  956 VVRDFKRPEGvSKEDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEVFFEslDEVDESALS 1035
                        1050      1060      1070      1080      1090
                  ....*....|....*....|....*....|....*....|....*....|
gi 94721241  1024 SVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELE--ITLTR 1071
Cdd:PLN02882 1036 QVLKSQAQYIRESLGSPLLPSSMMPSHAVVIAEESFHGVSGLSfkISLAR 1085
 
Name Accession Description Interval E-value
PLN02882 PLN02882
aminoacyl-tRNA ligase
6-1071 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 215477 [Multi-domain]  Cd Length: 1159  Bit Score: 1652.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     6 PENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:PLN02882    5 GKDFSFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGW 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    86 DCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQ 165
Cdd:PLN02882   85 DCHGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQ 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   166 LYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPL-EEDETVSLVAWTTTPWTLPSNLAVCVNPEMQY 244
Cdd:PLN02882  165 LFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIvGDPDNASFVAWTTTPWTLPSNLALCVNPNFTY 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   245 VKIKDVARGRLLILMEARLSALY-------------KLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENgAFTVLVDN 311
Cdd:PLN02882  245 VKVRNKYTGKVYIVAESRLSALPtakpkskkgskpeNAAEGYEVLAKVPGSSLVGKKYEPLFDYFSEFSDT-AFRVVADD 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   312 YVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVAT 391
Cdd:PLN02882  324 YVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKGGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSG 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   392 TFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWV 471
Cdd:PLN02882  404 SITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGTPLPIWI 483
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   472 SDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGK--GSLHRISEVFDCWFESGSMPYAQVHYPFENKREFE 549
Cdd:PLN02882  484 SDDGEEVVVIGSIAELEKLSGVKVTDLHRHFIDHITIPSSRGPefGVLRRVDDVFDCWFESGSMPYAYIHYPFENKELFE 563
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   550 DAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLIN 629
Cdd:PLN02882  564 KNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLIN 643
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   630 SPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFL-YNENTVRESPNITDRWILSFMQSLIGFFE 708
Cdd:PLN02882  644 SPVVRAEPLRFKEEGVFGVVKDVFLPWYNAYRFLVQNAKRLEVEGGAPFVpLDLAKLQNSANVLDRWINSATQSLVKFVR 723
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   709 TEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNL-KVL 787
Cdd:PLN02882  724 EEMGAYRLYTVVPYLVKFIDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLrKVL 803
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   788 idPVSVQdkdtlSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIK-SL 866
Cdd:PLN02882  804 --PGSEE-----SIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAEFLDDITgKL 876
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   867 EKYIIEELNVRKVTLSTDKNKYgIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIR 946
Cdd:PLN02882  877 KEYVLEELNVRSLVPCNDPLKY-ASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDILEFEKAGEVTIAGHTLKAGDIK 955
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   947 LMYTFDQATG-GTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYK--AKSEGTYLN 1023
Cdd:PLN02882  956 VVRDFKRPEGvSKEDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEVFFEslDEVDESALS 1035
                        1050      1060      1070      1080      1090
                  ....*....|....*....|....*....|....*....|....*....|
gi 94721241  1024 SVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELE--ITLTR 1071
Cdd:PLN02882 1036 QVLKSQAQYIRESLGSPLLPSSMMPSHAVVIAEESFHGVSGLSfkISLAR 1085
IleS COG0060
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ...
6-997 0e+00

Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439830 [Multi-domain]  Cd Length: 931  Bit Score: 1032.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    6 PENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:COG0060   13 PMRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGW 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   86 DCHGLPVEYEIDKTLGIRGPeDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQ 165
Cdd:COG0060   93 DCHGLPIELKVEKELGIKKK-DIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKK 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  166 LYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEED------ETVSLVAWTTTPWTLPSNLAVCVN 239
Cdd:COG0060  172 LYEKGLLYKGLKPVPWCPRCGTALAEAEV--EYKDVTSPSIYVKFPVKDEkallllEDAYLVIWTTTPWTLPANLAVAVH 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  240 PEMQYVKIKdVARGRLLILMEARLSAL---YKLEsDYEILERFPGAYLKGKKYRPLFDYFLKckENGAFTVLVDNYVKEE 316
Cdd:COG0060  250 PDIDYVLVE-VTGGERLILAEALVEAVlkeLGIE-DYEVLATFKGAELEGLRYEHPFYYVVG--YDRAHPVILGDYVTTE 325
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  317 EGTGVVHQAPYFGAEDYRVCMDFNiirkdsLPV-CPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTH 395
Cdd:COG0060  326 DGTGIVHTAPGHGEDDFEVGKKYG------LPVlNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITH 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  396 SYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPElVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDF 475
Cdd:COG0060  400 SYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPE-WGEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDC 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  476 EEVV----CIGSVAELEELSGAKIS---DLHRESVDHlTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVhypfENKREF 548
Cdd:COG0060  479 GELHrteeVIGSVAELLEEEGADAWfelDLHRPFLDE-TLKCPKCGGTMRRVPDVLDVWFDSGSMHFAVL----ENREEL 553
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  549 edAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI 628
Cdd:COG0060  554 --HFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVA 631
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  629 NSPvvRAENLRFKEEGVRDVlKDVLLPWYNAYRFLIQNVLrlqkeeeiEFLYNENTVR-ESPNITDRWILSFMQSLIGFF 707
Cdd:COG0060  632 SSD--YWGDLRFSDEILKEV-RDVYRRLRNTYRFLLANLD--------DFDPAEDAVPyEDLPELDRWILSRLNELIKEV 700
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  708 ETEMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRL-KGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLK 785
Cdd:COG0060  701 TEAYDNYDFHRAYRALHNFCVEdLSNWYLDISKDRLyTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLP 780
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  786 vlidpvsvqDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGR----VIRDRKTipIKYPLKEIVVIHQDPEALK 861
Cdd:COG0060  781 ---------GEAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLkaleAARKEKL--IRQPLEAAVVLYADEELAA 849
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  862 DIKSLEKYIIEELNVRKVTLSTDKNKYGirlraepdhmvlgkrlKGAFKAvmtsikqlsseeLEQFQKTGTIVVEghelh 941
Cdd:COG0060  850 ALESLGDLLAEELNVSEVELVDDAEDLG----------------KDALKA------------LDVEGISVTVEVE----- 896
                        970       980       990      1000      1010
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 94721241  942 dedirlmytfdQATGGTAQFEAHsdaqalVLLDVTPDQsmvdEGMAREVINRIQKL 997
Cdd:COG0060  897 -----------KADGEKCERCWH------YEVGWTPEH----EGLCRRCVRRVQGL 931
ileS TIGR00392
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ...
5-864 0e+00

isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273054 [Multi-domain]  Cd Length: 861  Bit Score: 985.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241      5 VPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFG 84
Cdd:TIGR00392    2 FPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPG 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     85 WDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFK 164
Cdd:TIGR00392   82 WDTHGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFK 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    165 QLYDKGLVYRGVKVMPFSTACNTPLSNFESHQ--NYKDVQDPSVFVTFPLEEDE-------TVSLVAWTTTPWTLPSNLA 235
Cdd:TIGR00392  162 EAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKktylkvkLSSLLIWTTTPWTLPSNLA 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    236 VCVNPEMQYVKIKDVARGRLLILMEARLSALY-KLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENGAFTVLVDNYVK 314
Cdd:TIGR00392  242 IAVHPDFEYALVQDNTKVEYFILAKKLVEKLYnKAGSDYEIIKTFKGSDLEGLEYEHPLYDFVSQLKEGAPVVIGGDHVT 321
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    315 EEEGTGVVHQAPYFGAEDYRVCmdfniiRKDSLPV-CPVDASGCFTTEVTDFAGQYVKDADKSIIRT-------LKEQGR 386
Cdd:TIGR00392  322 TEDGTGIVHTAPGHGEEDYEIG------KKYGLEVlSPVDEKGVYTEGVNDFQGRFVKDADKDIIKAnkiiieqLKDKGL 395
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    387 LLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVrEKRFGNWLKDARDWTISRNRYWGTP 466
Cdd:TIGR00392  396 LLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWG-EGRFGNWLENRPDWCISRQRYWGIP 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    467 IPLWVSDDFEEVVCIGSVAELEEL-----SGAKISDLHRESVDHLTIPSRCGkGSLHRISEVFDCWFESGSMPYAQVHYP 541
Cdd:TIGR00392  475 IPIWYCEDTGEPIVVGSIEELIELielkgIDAWFEDLHRDFLDKITLKSGDG-GEYRRVPDVLDVWFDSGSMPYASIHYP 553
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    542 FENKrEFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGAD 621
Cdd:TIGR00392  554 FENE-KFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGAD 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    622 ALRLYLINSpvVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQ--NVLRLQKEEEIEFLYNENTVrespnitDRWILSF 699
Cdd:TIGR00392  633 ILRLYVASS--DPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTyaNLDKFDPLFNSVAVEKFPEE-------DRWILSR 703
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    700 MQSLIGFFETEMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTE 778
Cdd:TIGR00392  704 LNSLVEEVNEALEKYNFHKVLRALQDFIVEeLSNWYIRIIRDRLYCEAKDNDKRAAQTTLYYALLTLVRLLAPFLPHTAE 783
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    779 LMYQNLKvlidpvsvQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPE 858
Cdd:TIGR00392  784 EIYQNLP--------GGEEEESVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELVIGKSLEA 855

                   ....*.
gi 94721241    859 ALKDIK 864
Cdd:TIGR00392  856 VLKAVE 861
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
17-639 0e+00

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 974.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     17 KILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEI 96
Cdd:pfam00133    1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     97 DKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGV 176
Cdd:pfam00133   81 EKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    177 KVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKikdvaRGRLL 256
Cdd:pfam00133  161 KLVNWSPALNTALSNLEV--EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI-----TGEGY 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    257 ILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFdyflkckENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVC 336
Cdd:pfam00133  234 ILAEALLKSLYKKGTDKKILEDFRGKELEGKEAIHPF-------VNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVG 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    337 MDFNIirkdsLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWF 416
Cdd:pfam00133  307 QRHNL-----EVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWF 381
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    417 VRVENMVDQLLRNNDLCYWVPELvREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEEL---SGA 493
Cdd:pfam00133  382 VRMDELADQALEAVEKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGrfeEEG 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    494 KISDLHRESVDHLtipsRCGKGSLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLV 573
Cdd:pfam00133  461 SIKWLHREAKDKL----GYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIM 536
                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 94721241    574 LATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLR 639
Cdd:pfam00133  537 LSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
IleRS_core cd00818
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ...
39-640 8.33e-158

catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173909 [Multi-domain]  Cd Length: 338  Bit Score: 475.57  E-value: 8.33e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   39 PKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNN 118
Cdd:cd00818    1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  119 QCRAIVMRYSAEWKSTVSRLGRWIDFDNDyktlypqfmesvwwvfkqlydkglvyrgvkvmpfstacntplsnfeshqnY 198
Cdd:cd00818   81 KCREFALRYVDEQEEQFQRLGVWVDWENP--------------------------------------------------Y 110
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  199 KdvqdpsvfvtfpleedetvslvawTTTPWTlpsnlavcvnpemqyvkikdvargrllilMEARLSALYKLesdyeiler 278
Cdd:cd00818  111 K------------------------TMDPEY-----------------------------MESVWWVFKQL--------- 128
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  279 fpgaYLKGKKYRplfdyflkckengaftvlvdnyvkeeegtgvvhqapyfgaeDYRVCMdfniirkdslpvcpvdasgcf 358
Cdd:cd00818  129 ----HEKGLLYR-----------------------------------------GYKVVP--------------------- 142
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  359 ttevtdfagqyvkdadksiirtlkeqgrllvattfthsypfcWrsdtPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPE 438
Cdd:cd00818  143 ------------------------------------------W----PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPE 176
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  439 LVREkRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCigsvaeleelsgakisdlhresvdhltipsrcgkgslH 518
Cdd:cd00818  177 WVKN-RFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV-------------------------------------R 218
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  519 RISEVFDCWFESGSMPYAQVHYPFENKrEFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDG 598
Cdd:cd00818  219 RVPDVLDVWFDSGSMPYAQLHYPFENE-DFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDG 297
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|..
gi 94721241  599 QKMSKRKKNYPDPVSIIQKYGADALRLYLINSPvVRAENLRF 640
Cdd:cd00818  298 RKMSKSLGNYVDPQEVVDKYGADALRLWVASSD-VYAEDLRF 338
 
Name Accession Description Interval E-value
PLN02882 PLN02882
aminoacyl-tRNA ligase
6-1071 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 215477 [Multi-domain]  Cd Length: 1159  Bit Score: 1652.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     6 PENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:PLN02882    5 GKDFSFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGW 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    86 DCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQ 165
Cdd:PLN02882   85 DCHGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQ 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   166 LYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPL-EEDETVSLVAWTTTPWTLPSNLAVCVNPEMQY 244
Cdd:PLN02882  165 LFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIvGDPDNASFVAWTTTPWTLPSNLALCVNPNFTY 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   245 VKIKDVARGRLLILMEARLSALY-------------KLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENgAFTVLVDN 311
Cdd:PLN02882  245 VKVRNKYTGKVYIVAESRLSALPtakpkskkgskpeNAAEGYEVLAKVPGSSLVGKKYEPLFDYFSEFSDT-AFRVVADD 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   312 YVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVAT 391
Cdd:PLN02882  324 YVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKGGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSG 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   392 TFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWV 471
Cdd:PLN02882  404 SITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGTPLPIWI 483
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   472 SDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGK--GSLHRISEVFDCWFESGSMPYAQVHYPFENKREFE 549
Cdd:PLN02882  484 SDDGEEVVVIGSIAELEKLSGVKVTDLHRHFIDHITIPSSRGPefGVLRRVDDVFDCWFESGSMPYAYIHYPFENKELFE 563
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   550 DAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLIN 629
Cdd:PLN02882  564 KNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLIN 643
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   630 SPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFL-YNENTVRESPNITDRWILSFMQSLIGFFE 708
Cdd:PLN02882  644 SPVVRAEPLRFKEEGVFGVVKDVFLPWYNAYRFLVQNAKRLEVEGGAPFVpLDLAKLQNSANVLDRWINSATQSLVKFVR 723
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   709 TEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNL-KVL 787
Cdd:PLN02882  724 EEMGAYRLYTVVPYLVKFIDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLrKVL 803
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   788 idPVSVQdkdtlSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIK-SL 866
Cdd:PLN02882  804 --PGSEE-----SIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAEFLDDITgKL 876
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   867 EKYIIEELNVRKVTLSTDKNKYgIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIR 946
Cdd:PLN02882  877 KEYVLEELNVRSLVPCNDPLKY-ASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDILEFEKAGEVTIAGHTLKAGDIK 955
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   947 LMYTFDQATG-GTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYK--AKSEGTYLN 1023
Cdd:PLN02882  956 VVRDFKRPEGvSKEDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEVFFEslDEVDESALS 1035
                        1050      1060      1070      1080      1090
                  ....*....|....*....|....*....|....*....|....*....|
gi 94721241  1024 SVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELE--ITLTR 1071
Cdd:PLN02882 1036 QVLKSQAQYIRESLGSPLLPSSMMPSHAVVIAEESFHGVSGLSfkISLAR 1085
PTZ00427 PTZ00427
isoleucine-tRNA ligase, putative; Provisional
5-1003 0e+00

isoleucine-tRNA ligase, putative; Provisional


Pssm-ID: 173617 [Multi-domain]  Cd Length: 1205  Bit Score: 1144.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     5 VPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFG 84
Cdd:PTZ00427   68 VSENPNIVEEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFG 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    85 WDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFK 164
Cdd:PTZ00427  148 WDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFS 227
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   165 QLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTF-------------PLEEDETV------------- 218
Cdd:PTZ00427  228 ELYKNNYVYKSFKVMPYSCKCNTPISNFELNLNYKDTPDPSIIISFvlcsdfpkveeecNIEEDKQLlgekysvlynnkr 307
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   219 --------------------SLVAWTTTPWTLPSNLAVCVNPEMQYVKIKDVARGRLLILMEARLSALYK-LESDYE--- 274
Cdd:PTZ00427  308 ensnngnnnstnnvcyaqhsEILAWTTTPWTLPSNLALCVNEHFTYLRIHHVKSNRVVIVGECRLEWIMKeLKWNVEdlk 387
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   275 ILERFPGAYLKGKKYRPLFDYFLKcKEN---GAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDS-LPVC 350
Cdd:PTZ00427  388 IVNRFKGKELKGLRYKPLFTNFYE-KYNfkeRAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIDPEKnIFID 466
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   351 PVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNN 430
Cdd:PTZ00427  467 PLDANGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNN 546
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   431 DLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEELSGAK-ISDLHRESVDHLTIP 509
Cdd:PTZ00427  547 ETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHLEELSGVKnINDLHRHFIDHIEIK 626
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   510 SRCGKG--SLHRISEVFDCWFESGSMPYAQVHYPFENKRE-FEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKN 586
Cdd:PTZ00427  627 NPKGKTypKLKRIPEVFDCWFESGSMPYAKVHYPFSTEKEdFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKN 706
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   587 VIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQN 666
Cdd:PTZ00427  707 LICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAVRAENLKFQEKGVNEVVKSFILPFYHSFRFFSQE 786
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   667 VLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGEN 746
Cdd:PTZ00427  787 VTRYECLNKKQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRDRMRGSL 866
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   747 GMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLK-VLIDPVSVQDKDT--------------LSIHYLMLPRVRE 811
Cdd:PTZ00427  867 GEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLRrVKSTNEHNENNETgntkegdlnrgvihKSVHFIMLPQVDE 946
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   812 E-LIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNkyGI 890
Cdd:PTZ00427  947 KyIIDYEIIELIEKMKDVILLGRVLRERRKVASKKPLKSITILHPNESYFKNFDQISNYIKEELNVLNVECSNDTS--CL 1024
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   891 RLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDI--RLMYTF-DQATggtaqfEAHSDA 967
Cdd:PTZ00427 1025 DFSAIPNYKTLGVKLGYNLKKVQNKIKNMDSESIKLYQQEGKITLDNVTLEGDDIiiQMKPNFqNDNT------DIISNN 1098
                        1050      1060      1070
                  ....*....|....*....|....*....|....*.
gi 94721241   968 QALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNL 1003
Cdd:PTZ00427 1099 YVTILMDFTTDQQLENMASARELCNHIQKMRKNLSL 1134
IleS COG0060
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ...
6-997 0e+00

Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439830 [Multi-domain]  Cd Length: 931  Bit Score: 1032.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    6 PENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:COG0060   13 PMRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGW 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   86 DCHGLPVEYEIDKTLGIRGPeDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQ 165
Cdd:COG0060   93 DCHGLPIELKVEKELGIKKK-DIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKK 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  166 LYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEED------ETVSLVAWTTTPWTLPSNLAVCVN 239
Cdd:COG0060  172 LYEKGLLYKGLKPVPWCPRCGTALAEAEV--EYKDVTSPSIYVKFPVKDEkallllEDAYLVIWTTTPWTLPANLAVAVH 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  240 PEMQYVKIKdVARGRLLILMEARLSAL---YKLEsDYEILERFPGAYLKGKKYRPLFDYFLKckENGAFTVLVDNYVKEE 316
Cdd:COG0060  250 PDIDYVLVE-VTGGERLILAEALVEAVlkeLGIE-DYEVLATFKGAELEGLRYEHPFYYVVG--YDRAHPVILGDYVTTE 325
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  317 EGTGVVHQAPYFGAEDYRVCMDFNiirkdsLPV-CPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTH 395
Cdd:COG0060  326 DGTGIVHTAPGHGEDDFEVGKKYG------LPVlNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITH 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  396 SYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPElVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDF 475
Cdd:COG0060  400 SYPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPE-WGEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDC 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  476 EEVV----CIGSVAELEELSGAKIS---DLHRESVDHlTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVhypfENKREF 548
Cdd:COG0060  479 GELHrteeVIGSVAELLEEEGADAWfelDLHRPFLDE-TLKCPKCGGTMRRVPDVLDVWFDSGSMHFAVL----ENREEL 553
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  549 edAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI 628
Cdd:COG0060  554 --HFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVA 631
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  629 NSPvvRAENLRFKEEGVRDVlKDVLLPWYNAYRFLIQNVLrlqkeeeiEFLYNENTVR-ESPNITDRWILSFMQSLIGFF 707
Cdd:COG0060  632 SSD--YWGDLRFSDEILKEV-RDVYRRLRNTYRFLLANLD--------DFDPAEDAVPyEDLPELDRWILSRLNELIKEV 700
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  708 ETEMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRL-KGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLK 785
Cdd:COG0060  701 TEAYDNYDFHRAYRALHNFCVEdLSNWYLDISKDRLyTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLP 780
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  786 vlidpvsvqDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGR----VIRDRKTipIKYPLKEIVVIHQDPEALK 861
Cdd:COG0060  781 ---------GEAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLkaleAARKEKL--IRQPLEAAVVLYADEELAA 849
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  862 DIKSLEKYIIEELNVRKVTLSTDKNKYGirlraepdhmvlgkrlKGAFKAvmtsikqlsseeLEQFQKTGTIVVEghelh 941
Cdd:COG0060  850 ALESLGDLLAEELNVSEVELVDDAEDLG----------------KDALKA------------LDVEGISVTVEVE----- 896
                        970       980       990      1000      1010
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 94721241  942 dedirlmytfdQATGGTAQFEAHsdaqalVLLDVTPDQsmvdEGMAREVINRIQKL 997
Cdd:COG0060  897 -----------KADGEKCERCWH------YEVGWTPEH----EGLCRRCVRRVQGL 931
ileS TIGR00392
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ...
5-864 0e+00

isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273054 [Multi-domain]  Cd Length: 861  Bit Score: 985.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241      5 VPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFG 84
Cdd:TIGR00392    2 FPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPG 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     85 WDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFK 164
Cdd:TIGR00392   82 WDTHGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFK 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    165 QLYDKGLVYRGVKVMPFSTACNTPLSNFESHQ--NYKDVQDPSVFVTFPLEEDE-------TVSLVAWTTTPWTLPSNLA 235
Cdd:TIGR00392  162 EAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKktylkvkLSSLLIWTTTPWTLPSNLA 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    236 VCVNPEMQYVKIKDVARGRLLILMEARLSALY-KLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENGAFTVLVDNYVK 314
Cdd:TIGR00392  242 IAVHPDFEYALVQDNTKVEYFILAKKLVEKLYnKAGSDYEIIKTFKGSDLEGLEYEHPLYDFVSQLKEGAPVVIGGDHVT 321
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    315 EEEGTGVVHQAPYFGAEDYRVCmdfniiRKDSLPV-CPVDASGCFTTEVTDFAGQYVKDADKSIIRT-------LKEQGR 386
Cdd:TIGR00392  322 TEDGTGIVHTAPGHGEEDYEIG------KKYGLEVlSPVDEKGVYTEGVNDFQGRFVKDADKDIIKAnkiiieqLKDKGL 395
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    387 LLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVrEKRFGNWLKDARDWTISRNRYWGTP 466
Cdd:TIGR00392  396 LLKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWG-EGRFGNWLENRPDWCISRQRYWGIP 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    467 IPLWVSDDFEEVVCIGSVAELEEL-----SGAKISDLHRESVDHLTIPSRCGkGSLHRISEVFDCWFESGSMPYAQVHYP 541
Cdd:TIGR00392  475 IPIWYCEDTGEPIVVGSIEELIELielkgIDAWFEDLHRDFLDKITLKSGDG-GEYRRVPDVLDVWFDSGSMPYASIHYP 553
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    542 FENKrEFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGAD 621
Cdd:TIGR00392  554 FENE-KFKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGAD 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    622 ALRLYLINSpvVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQ--NVLRLQKEEEIEFLYNENTVrespnitDRWILSF 699
Cdd:TIGR00392  633 ILRLYVASS--DPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTyaNLDKFDPLFNSVAVEKFPEE-------DRWILSR 703
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    700 MQSLIGFFETEMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTE 778
Cdd:TIGR00392  704 LNSLVEEVNEALEKYNFHKVLRALQDFIVEeLSNWYIRIIRDRLYCEAKDNDKRAAQTTLYYALLTLVRLLAPFLPHTAE 783
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    779 LMYQNLKvlidpvsvQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPE 858
Cdd:TIGR00392  784 EIYQNLP--------GGEEEESVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELVIGKSLEA 855

                   ....*.
gi 94721241    859 ALKDIK 864
Cdd:TIGR00392  856 VLKAVE 861
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
17-639 0e+00

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 974.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     17 KILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEI 96
Cdd:pfam00133    1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     97 DKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGV 176
Cdd:pfam00133   81 EKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    177 KVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKikdvaRGRLL 256
Cdd:pfam00133  161 KLVNWSPALNTALSNLEV--EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI-----TGEGY 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    257 ILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFdyflkckENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVC 336
Cdd:pfam00133  234 ILAEALLKSLYKKGTDKKILEDFRGKELEGKEAIHPF-------VNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVG 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    337 MDFNIirkdsLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWF 416
Cdd:pfam00133  307 QRHNL-----EVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWF 381
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    417 VRVENMVDQLLRNNDLCYWVPELvREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEEL---SGA 493
Cdd:pfam00133  382 VRMDELADQALEAVEKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGrfeEEG 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    494 KISDLHRESVDHLtipsRCGKGSLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLV 573
Cdd:pfam00133  461 SIKWLHREAKDKL----GYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIM 536
                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 94721241    574 LATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLR 639
Cdd:pfam00133  537 LSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
IleRS_core cd00818
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ...
39-640 8.33e-158

catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173909 [Multi-domain]  Cd Length: 338  Bit Score: 475.57  E-value: 8.33e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   39 PKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNN 118
Cdd:cd00818    1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  119 QCRAIVMRYSAEWKSTVSRLGRWIDFDNDyktlypqfmesvwwvfkqlydkglvyrgvkvmpfstacntplsnfeshqnY 198
Cdd:cd00818   81 KCREFALRYVDEQEEQFQRLGVWVDWENP--------------------------------------------------Y 110
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  199 KdvqdpsvfvtfpleedetvslvawTTTPWTlpsnlavcvnpemqyvkikdvargrllilMEARLSALYKLesdyeiler 278
Cdd:cd00818  111 K------------------------TMDPEY-----------------------------MESVWWVFKQL--------- 128
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  279 fpgaYLKGKKYRplfdyflkckengaftvlvdnyvkeeegtgvvhqapyfgaeDYRVCMdfniirkdslpvcpvdasgcf 358
Cdd:cd00818  129 ----HEKGLLYR-----------------------------------------GYKVVP--------------------- 142
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  359 ttevtdfagqyvkdadksiirtlkeqgrllvattfthsypfcWrsdtPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPE 438
Cdd:cd00818  143 ------------------------------------------W----PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPE 176
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  439 LVREkRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCigsvaeleelsgakisdlhresvdhltipsrcgkgslH 518
Cdd:cd00818  177 WVKN-RFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV-------------------------------------R 218
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  519 RISEVFDCWFESGSMPYAQVHYPFENKrEFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDG 598
Cdd:cd00818  219 RVPDVLDVWFDSGSMPYAQLHYPFENE-DFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDG 297
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|..
gi 94721241  599 QKMSKRKKNYPDPVSIIQKYGADALRLYLINSPvVRAENLRF 640
Cdd:cd00818  298 RKMSKSLGNYVDPQEVVDKYGADALRLWVASSD-VYAEDLRF 338
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
6-937 1.04e-128

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 417.15  E-value: 1.04e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241      6 PENINFPAEEEKILEFWTEFNCFQecLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGW 85
Cdd:TIGR00422    2 PKDYDPHEVEKKWYKKWEKSGFFK--PDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGT 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     86 DCHGLPVEYEIDKTLGIRGPE--DVakmGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVF 163
Cdd:TIGR00422   80 DHAGIATQVKVEKKLGAEGKTkhDL---GREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAF 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    164 KQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEmq 243
Cdd:TIGR00422  157 VRLYEKGLIYRGEYLVNWDPKLNTAISDIEV--EYKEVKGKLYYIRYPLANGSKDYLVVATTRPETMFGDTAVAVHPE-- 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    244 yvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLFDYFLKckengaftVLVDNYVKEEEGTGVV 322
Cdd:TIGR00422  233 ----------------------------D----ERY--KHLIGKKVIlPLTGRKIP--------IIADEYVDMEFGTGAV 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    323 HQAPyfgAEDYRvcmDFNIIRKDSLP-VCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCW 401
Cdd:TIGR00422  271 KVTP---AHDFN---DYEWGKRHNLEfINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCW 344
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    402 RSDTPLIYKAVPSWFVRVENMVDQLLR--NNDLCYWVPELVrEKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVV 479
Cdd:TIGR00422  345 RSGTVVEPLLSKQWFVKVEKLADKALEaaEEGEIKFVPKRM-EKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGEVY 423
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    480 cigsVAELEELSGAKISDlhresvdhltipsrCGKGSLHRISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFIAE 559
Cdd:TIGR00422  424 ----VAKEEPLPDDKTNT--------------GPSVELEQDTDVLDTWFSSSLWPFSTLGWP-DETKDLKKFYPTDLLVT 484
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    560 GIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSpVVRAENLR 639
Cdd:TIGR00422  485 GYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASL-VTPGDDIN 563
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    640 FKE---EGVRDVLKDVllpwYNAYRFLIQNVlrlqkEEEIEFLYNENTVRESpnitDRWILSFMQSLIGFFETEMAAYRL 716
Cdd:TIGR00422  564 FDWkrvESARNFLNKL----WNASRFVLMNL-----SDDLELSGGEEKLSLA----DRWILSKLNRTIKEVRKALDKYRF 630
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    717 YTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEDcVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKvlidpvsvqd 795
Cdd:TIGR00422  631 AEAAKALYEFIwNDFCDWYIELVKYRLYNGNEAEK-KAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK---------- 699
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    796 KDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALKDIKSLEKYIIEELN 875
Cdd:TIGR00422  700 EGADSIMLQSYPVVDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLK-VLLIYTEAETAERLKLNAVDIKGAIN 778
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 94721241    876 VRKVTLSTDKNKYGIRL-RAEPDHMVLG--KRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEG 937
Cdd:TIGR00422  779 FSEVEVVIEKPEVTEAVvELVPGFEIIIpvKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEG 843
valS PRK13208
valyl-tRNA synthetase; Reviewed
1-885 6.09e-107

valyl-tRNA synthetase; Reviewed


Pssm-ID: 237306 [Multi-domain]  Cd Length: 800  Bit Score: 356.42  E-value: 6.09e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     1 MLQQVPENINFPAEEEKILEFWTEFNCFQEclKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVD 80
Cdd:PRK13208    2 MMPELPKKYDPEELEEKWQKIWEEEGTYKF--DPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    81 RRFGWDCHGLPVEYEIDKTLGIRgPEDVAKmgiTEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTlypqfMESVW 160
Cdd:PRK13208   80 FPQGWDDNGLPTERKVEKYYGIR-KDDISR---EEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQT-----ISPEY 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   161 WV-----FKQLYDKGLVYRGVKVMPFSTACNTPLSNFEshQNYKDVQDPSVFVTFPLEEDETVsLVAwTTTPWTLPSNLA 235
Cdd:PRK13208  151 RRisqksFLDLYKKGLIYRAEAPVLWCPRCETAIAQAE--VEYREREGKLNYIKFPVEDGEEI-EIA-TTRPELLPACVA 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   236 VCVNPEmqyvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLFDYFLKckengaftVLVDNYVK 314
Cdd:PRK13208  227 VVVHPD------------------------------D----ERY--KHLVGKTAIvPLFGVEVP--------ILADPLVD 262
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   315 EEEGTGVVHqapyfgaedyrVC-----MDFNIIRKDSLPVCPV-DASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLL 388
Cdd:PRK13208  263 PDFGTGAVM-----------ICtfgdkTDVTWWRELNLPTRIIiDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLG 331
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   389 VATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVReKRFGNWLKD-ARDWTISRNRYWGTPI 467
Cdd:PRK13208  332 KQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMR-VRLENWIEGlNWDWCISRQRYFGTPI 410
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   468 PLWVSDDFEEVVcigsVAELEELSgakisdlhresVDhltiPSR----------CGKGSLHRISEVFDCWFESGSMPYAQ 537
Cdd:PRK13208  411 PVWYCKDCGHPI----LPDEEDLP-----------VD----PTKdeppgykcpqCGSPGFEGETDVMDTWATSSITPLIV 471
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   538 VHYPfENKREFEDAFPADFIAEGIDQTRGW-FYTLLvLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQ 616
Cdd:PRK13208  472 TGWE-RDEDLFEKVFPMDLRPQGHDIIRTWlFYTIL-RAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLE 549
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   617 KYGADALRLYLINSPVvrAENLRFKEEGV----RDVLKdvLLpwyNAYRFliqnVLRLQKEEEIEFLYNENTVrespnit 692
Cdd:PRK13208  550 KYGADAVRYWAASARL--GSDTPFDEKQVkigrRLLTK--LW---NASRF----VLHFSADPEPDKAEVLEPL------- 611
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   693 DRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAP 771
Cdd:PRK13208  612 DRWILAKLAKVVEKATEALENYDFAKALEEIESFFwHVFCDDYLELVKSRAYGEDEEEEQKSARYTLYTVLDTLLRLLAP 691
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   772 YTPFLTELMYQNLKvlidpvsvqdkdTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIV 851
Cdd:PRK13208  692 FLPFITEEVWSWLY------------GGSVHRASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVE 759
                         890       900       910
                  ....*....|....*....|....*....|....
gi 94721241   852 VIhqDPEALKDIKSLEKYIIEELNVRKVTLSTDK 885
Cdd:PRK13208  760 VY--GPADLELLEAAEEDLKAAGNIEELELVEGD 791
PLN02843 PLN02843
isoleucyl-tRNA synthetase
10-784 1.87e-106

isoleucyl-tRNA synthetase


Pssm-ID: 215452 [Multi-domain]  Cd Length: 974  Bit Score: 359.47  E-value: 1.87e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    10 NFPAEEEKILEFWTEFNCFQECLKQSKHKPkFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHG 89
Cdd:PLN02843    4 NSVTREPEIQKLWEENQVYKRVSDRNNGES-FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    90 LPVEYEIDKTLGirgPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDK 169
Cdd:PLN02843   83 LPIELKVLQSLD---QEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   170 GLVYRGVKVMPFSTACNTPLSnfESHQNYKDVQ-DPSVFVTFPL---------EEDE---TVSLVAWTTTPWTLPSNLAV 236
Cdd:PLN02843  160 GYIYRGRKPVHWSPSSRTALA--EAELEYPEGHvSKSIYVAFPVvspsetspeELEEflpGLSLAIWTTTPWTMPANAAV 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   237 CVNPEMQY--VKIKDVA---------------------RGRLLILMEARLSAL-YKLESDYEILERFPGAYLKGKKYR-P 291
Cdd:PLN02843  238 AVNDKLQYsvVEVQSFSedestsggnkkkrpgnvlkeqQKLFLIVATDLVPALeAKWGVKLVVLKTFPGSDLEGCRYIhP 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   292 LFDYflKCKengafTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMdfniirKDSLP-VCPVDASGCFTTEVTDFAGQYV 370
Cdd:PLN02843  318 LYNR--ESP-----VVIGGDYITTESGTGLVHTAPGHGQEDYITGL------KYGLPlLSPVDDAGKFTEEAGQFSGLSV 384
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   371 -KDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPElVREKRFGNWL 449
Cdd:PLN02843  385 lGEGNAAVVEALDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPA-QGENRIRAMV 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   450 KDARDWTISRNRYWGTPIPLWVSDDFEEVV----CIGSVAELEELSGA------KISDLHRESVDHLTipsrcgkGSLHR 519
Cdd:PLN02843  464 SGRSDWCISRQRTWGVPIPVFYHVETKEPLmneeTIAHVKSIVAQKGSdawwymDVEDLLPEKYRDKA-------SDYEK 536
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   520 ISEVFDCWFESGSmPYAQVhypfeNKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQ 599
Cdd:PLN02843  537 GTDTMDVWFDSGS-SWAGV-----LGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGF 610
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   600 KMSKRKKNYPDPVSII-----QK----YGADALRLY----------LINSPVVR--AENLRfkeeGVRDVLkdvllpwyn 658
Cdd:PLN02843  611 KMSKSLGNVVDPRLVIeggknQKqepaYGADVLRLWvasvdytgdvLIGPQILKqmSDIYR----KLRGTL--------- 677
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   659 ayRFLIQNVLRLQKEEEIEFlynentvrESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDI-LTNWYVRM 737
Cdd:PLN02843  678 --RYLLGNLHDWKPDNAVPY--------EDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVdLSNFYLDV 747
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*....
gi 94721241   738 NRRRLkGENGMEDCV-MALET-LFSVLLSLCRLMAPYTPFLTELMYQNL 784
Cdd:PLN02843  748 AKDRL-YVGGTTSFTrRSCQTvLAAHLLSLLRAIAPILPHLAEDAWQNL 795
Anticodon_Ia_Ile_ABEc cd07961
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ...
640-833 8.09e-84

Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153415 [Multi-domain]  Cd Length: 183  Bit Score: 270.96  E-value: 8.09e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  640 FKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEieflyNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTV 719
Cdd:cd07961    1 FSEKGVREVVRKVLLPLWNAYRFFVTYANLDGFDPG-----KDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTA 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  720 VPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIdpvsvqDKDTL 799
Cdd:cd07961   76 VRALLEFIDELTNWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRREL------GDAPE 149
                        170       180       190
                 ....*....|....*....|....*....|....
gi 94721241  800 SIHYLMLPRVREELIDKKTESAVSQMQSVIELGR 833
Cdd:cd07961  150 SVHLLDWPEVDESLIDEELEEAMELVREIVELGR 183
valS PRK14900
valyl-tRNA synthetase; Provisional
15-859 4.21e-70

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 256.07  E-value: 4.21e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    15 EEKILEFWTEFNCFQeCLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEY 94
Cdd:PRK14900   25 EARWYPFWQERGYFH-GDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQM 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    95 EIDKTLgiRGPEDVAK--MGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLV 172
Cdd:PRK14900  104 IVEKEL--KKTEKKSRhdLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLI 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   173 YRGVKVMPFSTACNTPLSNFE-SHQNYKDVQDPSVfvTFPLEeDETVSLVAWTTTPWTLPSNLAVCVNPEmqyvkikdva 251
Cdd:PRK14900  182 YREKKLINWCPDCRTALSDLEvEHEEAHQGELWSF--AYPLA-DGSGEIVVATTRPETMLGDTAVAVHPL---------- 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   252 rgrllilmEARLSALYklesdyeilerfpgaylkGKKYR-PLFDYFLKCKengAFTVLVDnyvkEEEGTGVVHQAPyfgA 330
Cdd:PRK14900  249 --------DPRYMALH------------------GKKVRhPITGRTFPIV---ADAILVD----PKFGTGAVKVTP---A 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   331 EDYRvcmDFNIIRKDSLPVCPV-DASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGrlLVATTFTHSYPF--CWRSDTPL 407
Cdd:PRK14900  293 HDFN---DFEVGKRHGLEMITViGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQG--LDRGAKPHVLPLgrCQRSATIL 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   408 IYKAVPSWFVRVENMVDQLLR--NNDLCYWVPELVREKRFGnWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCigsva 485
Cdd:PRK14900  368 EPLLSDQWYVRIEPLARPAIEavEQGRTRFIPEQWTNTYMA-WMRNIHDWCISRQLWWGHQIPAWYCPDGHVTVA----- 441
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   486 eleelsgakisdlhRESVDHLtipSRCGKGSLHRISEVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTR 565
Cdd:PRK14900  442 --------------RETPEAC---STCGKAELRQDEDVLDTWFSSGLWPFSTMGWP-EQTDTLRTFYPTSVMETGHDIIF 503
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   566 GWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLInSPVVRAENLRFKE--- 642
Cdd:PRK14900  504 FWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLA-ALTAQGRDIKLAKeri 582
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   643 EGVRDVLKDVllpwYNAYRFLIQNVLrlqkeeeiEFLYNENTVRESP-NITDRWILSFMQSLIGFFETEMAAYRLYTVVP 721
Cdd:PRK14900  583 EGYRAFANKL----WNASRFALMNLS--------GYQERGEDPARLArTPADRWILARLQRAVNETVEALEAFRFNDAAN 650
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   722 RLVKFV-DILTNWYVRMNRRRLKGEN-GMEDCVMAleTLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVQDkdtl 799
Cdd:PRK14900  651 AVYAFVwHELCDWYIELAKEALASEDpEARRSVQA--VLVHCLQTSYRLLHPFMPFITEELWHVLRAQVGASAWAD---- 724
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 94721241   800 SIHYLMLPRVREelIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPL---KEIVVIHQDPEA 859
Cdd:PRK14900  725 SVLAAEYPRKGE--ADEAAEAAFRPVLGIIDAVRNIRGEMGIPWKVKLgaqAPVEIAVADPAL 785
valS PRK05729
valyl-tRNA synthetase; Reviewed
12-887 1.56e-67

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 245.78  E-value: 1.56e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    12 PAE-EEKILEFWTEFNCFQeclKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDrrfgWdchgL 90
Cdd:PRK05729   11 PKEvEAKWYQKWEEKGYFK---PDDNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTL----W----L 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    91 P------------VEYEIDKTlgirgpedvakmGITeynnqcraivmRYSA----------EWK--------STVSRLGR 140
Cdd:PRK05729   80 PgtdhagiatqmvVERQLAAE------------GKS-----------RHDLgrekflekvwEWKeesggtitNQLRRLGA 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   141 WIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSL 220
Cdd:PRK05729  137 SCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV--EYKEVKGKLWHIRYPLADGSDYLV 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   221 VAwTTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLFDYFLKc 299
Cdd:PRK05729  215 VA-TTRPETMLGDTAVAVNPE------------------------------D----ERY--KHLIGKTVIlPLVGREIP- 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   300 kengaftVLVDNYVKEEEGTGVV-----HqapyfgaedyrvcmDFN---IIRKDSLPVCPV-DASGCFTTEVTDFAGQYV 370
Cdd:PRK05729  257 -------IIADEYVDPEFGTGAVkitpaH--------------DPNdfeVGKRHNLPMINImDEDGTINENPGEYQGLDR 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   371 KDADKSIIRTLKEQGrLLVAT-TFTHSYPFCWRSDT---PLIYKavpSWFVRVENMVDQLL---RNNDLCYwVPElvR-E 442
Cdd:PRK05729  316 FEARKAIVADLEELG-LLVKIePHTHSVGHSDRSGVviePYLSD---QWFVKMKPLAKPALeavENGEIKF-VPE--RwE 388
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   443 KRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVcigsvAELEelsgakisdlhresvdhltiPSRCGKGSLHRISE 522
Cdd:PRK05729  389 KTYFHWMENIQDWCISRQLWWGHRIPAWYDEDGEVYV-----GREE--------------------PEAREKALLTQDED 443
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   523 VFDCWFESGSMPYAQVHYPfENKREFEDAFPADfiaegidqtrgwfytllVLATA---LF--------------GQPPFK 585
Cdd:PRK05729  444 VLDTWFSSALWPFSTLGWP-EKTEDLKRFYPTS-----------------VLVTGfdiIFfwvarmimmglhftGQVPFK 505
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   586 NVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI--NSPvvrAENLRFKE---EGVRDV---LkdvllpwY 657
Cdd:PRK05729  506 DVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIRFDEervEGYRNFankL-------W 575
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   658 NAYRFLIQNVLRLQKEEEIEflynentvRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVR 736
Cdd:PRK05729  576 NASRFVLMNLEGADVGELPD--------PEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIwNEFCDWYLE 647
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   737 MNRRRLKGENGMEdcvmALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSvqdkdtlsihyLML---PRVREEL 813
Cdd:PRK05729  648 LAKPVLQEAAKRA----TRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEES-----------IMLapwPEADEAI 712
                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 94721241   814 iDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNK 887
Cdd:PRK05729  713 -DEAAEAEFEWLKELITAIRNIRAEMNIPPSKKLP-LLLKGADAEDRARLEANEAYIKRLARLESLEILADDEE 784
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
12-885 1.64e-66

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 242.65  E-value: 1.64e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   12 PAE-EEKILEFWTEFNCFQEclKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrrfGWdchgL 90
Cdd:COG0525    9 PKEvEAKWYQYWEENGYFKA--DPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNT----LW----Q 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   91 P------------VEYEIDKTlgirgpedvakmGITeynnqcraivmRYSA----------EWK----STVS----RLGR 140
Cdd:COG0525   79 PgtdhagiatqavVERQLAEE------------GKS-----------RHDLgrekflervwEWKeesgGTITnqlrRLGA 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  141 WIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVFVTFPLEEDETVSL 220
Cdd:COG0525  136 SCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEV--EHEEVKGHLWHIRYPLADGSGYIV 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  221 VAwTTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmearlsalyklesDyeilERFpgAYLKGKKYR-PLFdyflkc 299
Cdd:COG0525  214 VA-TTRPETMLGDTAVAVHPE------------------------------D----ERY--KHLIGKTVIlPLV------ 250
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  300 keNGAFTVLVDNYVKEEEGTGVV-----HqapyfgaedyrvcmDFN---IIRKDSLPVCPV-DASGCFTTEVTDFAGQYV 370
Cdd:COG0525  251 --GREIPIIADEYVDPEFGTGAVkitpaH--------------DPNdfeVGKRHNLPMINIlDEDGTINENAGKYRGLDR 314
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  371 KDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDT---PLIykavpS--WFVRVENMVDQLL---RNNDLcYWVPElvR- 441
Cdd:COG0525  315 FEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTviePYL-----SdqWFVKMKPLAKPAIeavEDGEI-KFVPE--Rw 386
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  442 EKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDfEEVVcigsVAELEElsgakisdlhresvdhlTIPSRCGKGSLHRIS 521
Cdd:COG0525  387 EKTYFHWMENIRDWCISRQLWWGHRIPAWYCPD-GEVY----VARTEP-----------------EACAKAGSVNLTQDE 444
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  522 EVFDCWFESGSMPYAQVHYPFENKrEFEDAFPADfiaegidqtrgwfytllVLATA---LF--------------GQPPF 584
Cdd:COG0525  445 DVLDTWFSSALWPFSTLGWPEKTE-DLKYFYPTS-----------------VLVTGfdiIFfwvarmimmglhftGEVPF 506
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  585 KNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI--NSPvvrAENLRFKE---EGVRDV---LkdvllpW 656
Cdd:COG0525  507 KDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIKFDEervEGYRNFankL------W 577
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  657 yNAYRFLIQNvlrlqkeeEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYV 735
Cdd:COG0525  578 -NASRFVLMN--------LEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVwNEFCDWYL 648
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  736 RMNRRRLKGENGMEDCVmALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSvqdkdtlsihyLML---PRVREE 812
Cdd:COG0525  649 ELAKPRLYGGDEAAKRE-TRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEGES-----------IMLapwPEADEE 716
                        890       900       910       920       930       940       950
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 94721241  813 LIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKeIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDK 885
Cdd:COG0525  717 LIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLP-LLLKGADEADRARLEENAAYIKRLARLEEITILVDE 788
PLN02943 PLN02943
aminoacyl-tRNA ligase
13-784 1.88e-54

aminoacyl-tRNA ligase


Pssm-ID: 215509 [Multi-domain]  Cd Length: 958  Bit Score: 207.10  E-value: 1.88e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    13 AEEEKILEFWTEFNCFQECLKQSKHKpkFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPV 92
Cdd:PLN02943   64 TSEERIYNWWESQGYFKPNFDRGGDP--FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIAT 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    93 EYEIDKTLGIRGPEDVaKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLV 172
Cdd:PLN02943  142 QLVVEKMLASEGIKRT-DLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLI 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   173 YRGVKVMPFSTACNTPLSNFESHqnYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPE----MQYVkik 248
Cdd:PLN02943  221 YQGSYMVNWSPNLQTAVSDLEVE--YSEEPGTLYYIKYRVAGGSEDFLTIATTRPETLFGDVAIAVNPEddrySKYI--- 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   249 dvarGRLLILmearlsalyklesdyeilerfPgayLKGKKYRPlfdyflkckengaftVLVDNYVKEEEGTGVVHQAPYF 328
Cdd:PLN02943  296 ----GKMAIV---------------------P---MTYGRHVP---------------IIADRYVDKDFGTGVLKISPGH 332
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   329 GAEDYRvcmdfnIIRKDSLPVCPV---DASgcftteVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDT 405
Cdd:PLN02943  333 DHNDYL------LARKLGLPILNVmnkDGT------LNEVAGLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   406 ---PLIYKavpSWFVRVENMVDQLLR---NNDLCYwVPELVrEKRFGNWLKDARDWTISRNRYWGTPIPLW--VSDDFEE 477
Cdd:PLN02943  401 viePLVSK---QWFVTMEPLAEKALKaveNGELTI-IPERF-EKIYNHWLSNIKDWCISRQLWWGHRIPVWyiVGKDCEE 475
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   478 VVCigsVAELEELSGAKISDLHRESVDhltipsrcgkgsLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFI 557
Cdd:PLN02943  476 DYI---VARSAEEALEKAREKYGKDVE------------IYQDPDVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPTTVL 540
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   558 AEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAEN 637
Cdd:PLN02943  541 ETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLN 620
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   638 LRFKEEGVRDVLKDVLlpwYNAYRFLIQNVLRLQKEEEIEFLYN-----ENTVRESPnITDRWILSFMQSLIGFFETEMA 712
Cdd:PLN02943  621 LSTERLTSNKAFTNKL---WNAGKFVLQNLPSQSDTSAWEHILAckfdkEESLLSLP-LPECWVVSKLHELIDSVTTSYD 696
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 94721241   713 AYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNL 784
Cdd:PLN02943  697 KYFFGDVGREIYDFFwSDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQAL 769
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
15-887 7.41e-54

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 205.24  E-value: 7.41e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    15 EEKILEFWTEFNCFQ--ECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLP- 91
Cdd:PTZ00419   34 ESGWYEWWEKSGFFKpaEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIAt 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    92 ---VEYEIDKTLG-IR---GPEDVAKMgITEYNNQcraivmrYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFK 164
Cdd:PTZ00419  114 qvvVEKKLMKEENkTRhdlGREEFLKK-VWEWKDK-------HGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFV 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   165 QLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVF----------------VTFPLEEDETVSLVAWTTTPW 228
Cdd:PTZ00419  186 RLYEDGLIYRDTRLVNWCCYLKTAISDIEV--EFEEIEKPTKItipgydkkvevgvlwhFAYPLEDSGQEEIVVATTRIE 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   229 TLPSNLAVCVNPemqyvkiKDvargrllilmearlsalyklesdyeilERFpgAYLKGKkyrplfdyFLKC---KENGAF 305
Cdd:PTZ00419  264 TMLGDVAVAVHP-------KD---------------------------ERY--KKLHGK--------ELIHpfiPDRKIP 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   306 TVLVDNYVKEEEGTGVVHQAPyfgAEDYRvcmDFNIIRKDSLPVCPV-DASGCFTTEVTDFAGQYVKDADKSIIRTLKEQ 384
Cdd:PTZ00419  300 IIADDELVDMEFGTGAVKITP---AHDPN---DYEIAKRHNLPFINIfTLDGKINENGGEFAGMHRFDCRRKIEEELKEM 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   385 GRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQ---LLRNNDLCYWVPELVREkrFGNWLKDARDWTISRNR 461
Cdd:PTZ00419  374 GLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRaveAVRNGELKIIPSSHENV--WYHWLENIQDWCISRQL 451
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   462 YWGTPIP-----------------LWV-SDDFEEvvCIGSVAELEELSGAKISdlhresvdhltipsrcgkgsLHRISEV 523
Cdd:PTZ00419  452 WWGHRIPayrviskgpetdpsdeePWVvARSEEE--ALEKAKKKFGLSEEDFE--------------------LEQDEDV 509
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   524 FDCWFESGSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSK 603
Cdd:PTZ00419  510 LDTWFSSGLFPFSTLGWP-DQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSK 588
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   604 RKKNYPDPVSIIQKYGADAL--RLYLINSP---VVRAENLRFKE--EGV-------------------RDVLKDV----- 652
Cdd:PTZ00419  589 SKGNVIDPLEVIEGISLQDLnqKLYEGNLPekeIKRAIELQKKEfpNGIpecgtdalrfgllaytqqgRNINLDInrvvg 668
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   653 -------LlpWyNAYRFLIQNVLRLQKeeEIEFLYNENTVRESPNITDRWILSFMQSLIG----------FFETEMAAYR 715
Cdd:PTZ00419  669 yrhfcnkL--W-NAVKFALMKLLKDFN--LPNSTLFKPNNVESLPWEDKWILHRLNVAIKevtegfkeydFSEATQATYN 743
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   716 LYtvvprLVKFVDIltnwYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLkvlidPVSVQD 795
Cdd:PTZ00419  744 FW-----LYELCDV----YLELIKPRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRL-----PNYLRK 809
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   796 KDTLSI-HYlmlPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPeaLKDIKSLEKYIIEEL 874
Cdd:PTZ00419  810 SESISIaKY---PQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAE--LIELIESAENLISTL 884
                         970
                  ....*....|....
gi 94721241   875 -NVRKVTLSTDKNK 887
Cdd:PTZ00419  885 aKIGSVSVIPPIEE 898
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
47-630 1.09e-52

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 190.15  E-value: 1.09e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   47 PPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDvAKMGITEYNNQCRAIVMR 126
Cdd:cd00817    9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTR-HDLGREEFLEKCWEWKEE 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  127 YSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVyrgvkvmpfstacntplsnfeshqnYKDVQdpsv 206
Cdd:cd00817   88 SGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLI-------------------------YRDNR---- 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  207 fvtfpleedetvsLVAWTTTpwtlpsnlavCvnpemqyvkikdvargrllilmearLSALykleSDYEIlerfpgaylkg 286
Cdd:cd00817  139 -------------LVNWCPK----------L-------------------------RTAI----SDIEV----------- 155
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  287 kkyrplfdyflkckengaftvlvdnyvkeeegtgvvhqapyfgaedyrvcmdfniirkdslpvcpvdasgcfttevtdfa 366
Cdd:cd00817      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  367 gqyvkdadksiirtlkeqgrllvattfthsypfCWRSDTPLIYKAVPSWFVRVENMVDQLLR--NNDLCYWVPELVrEKR 444
Cdd:cd00817  156 ---------------------------------CSRSGDVIEPLLKPQWFVKVKDLAKKALEavKEGDIKFVPERM-EKR 201
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  445 FGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVcigsVAELEELSGAKISDLHREsvdhltipsRCGKGSLHRISEVF 524
Cdd:cd00817  202 YENWLENIRDWCISRQLWWGHRIPAWYCKDGGHWV----VAREEDEAIDKAAPEACV---------PCGGEELKQDEDVL 268
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  525 DCWFESGSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTRGW-FYTLLvLATALFGQPPFKNVIVNGLVLASDGQKMSK 603
Cdd:cd00817  269 DTWFSSSLWPFSTLGWP-EETKDLKKFYPTSLLVTGHDIIFFWvARMIM-RGLKLTGKLPFKEVYLHGLVRDEDGRKMSK 346
                        570       580
                 ....*....|....*....|....*..
gi 94721241  604 RKKNYPDPVSIIQKYGADALRLYLINS 630
Cdd:cd00817  347 SLGNVIDPLDVIDGYGADALRFTLASA 373
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
390-628 1.73e-49

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 178.38  E-value: 1.73e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  390 ATTFTHSYPFCWRS-----DTPLIYK------AVPSWFVRVENMVDQLLRNNDLCYWVPELVReKRFGNWLKDARDWTIS 458
Cdd:cd00668  106 ITTEPEYSKAVELIfsrlyEKGLIYRgthpvrITEQWFFDMPKFKEKLLKALRRGKIVPEHVK-NRMEAWLESLLDWAIS 184
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  459 RNRYWGTPIPLWVsddfeevvcigsvaeleelsgakisdlhresvdhltipsrcgkgslhrisevFDCWFESGSMPYAQV 538
Cdd:cd00668  185 RQRYWGTPLPEDV----------------------------------------------------FDVWFDSGIGPLGSL 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  539 HYPFENkREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKY 618
Cdd:cd00668  213 GYPEEK-EWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKY 291
                        250
                 ....*....|
gi 94721241  619 GADALRLYLI 628
Cdd:cd00668  292 GADALRYYLT 301
leuS PRK12300
leucyl-tRNA synthetase; Reviewed
54-950 2.49e-40

leucyl-tRNA synthetase; Reviewed


Pssm-ID: 237049 [Multi-domain]  Cd Length: 897  Bit Score: 161.96  E-value: 2.49e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    54 PHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVeyeidktLGI-----RGPEDVakmgITEYNNQCR------- 121
Cdd:PRK12300    1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPI-------LGIaeriaRGDPET----IELYKSLYGipeeele 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   122 ------AIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLsnfESH 195
Cdd:PRK12300   70 kfkdpeYIVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPV---GDH 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   196 qNYKDVQDPSV--FVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKIKdvARGRLLILMEArlsALYKL---E 270
Cdd:PRK12300  147 -DLLDGEEPEIveYTLIKFEESEDLILPAATLRPETIFGVTNLWVNPDATYVKAE--VDGEKWIVSKE---AAEKLsfqD 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   271 SDYEILERFPGAYLKGKKYR-PLFDyflkcKEngaFTVLVDNYVKEEEGTGVV-----HqAPYfgaeDYRVCMDFNIIRK 344
Cdd:PRK12300  221 RDVEIIEEIKGSELIGKKVKnPVTG-----KE---VPILPADFVDPDNGTGVVmsvpaH-APY----DYVALRDLKKNKE 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   345 DS-----LPVCPVDASGCF----------------------TTEV--------------TDFAGQYVKDADKSIIRTLKE 383
Cdd:PRK12300  288 LLdviepIPLIEVEGYGEFpakevveklgiksqedpeleeaTKEVyraefhkgvlkentGEYAGKPVREAREKITKDLIE 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   384 QGRLLVATTFTHSYPFCwRSDTPLIYKAVP-SWFV---------RVENMVDQLlrnnDLcywVPELVReKRFGN---WLK 450
Cdd:PRK12300  368 KGIADIMYEFSNRPVYC-RCGTECVVKVVKdQWFIdysdpewkeLAHKALDNM----EI---IPEEYR-KEFENtidWLK 438
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   451 DardWTISRNRYWGTPIPlWvsdDFEEVVcigsvaelEELS------------------GAKISDLHRESVDHLTIpsrc 512
Cdd:PRK12300  439 D---RACARRRGLGTRLP-W---DEEWII--------ESLSdstiymayytiahkireyGIKPEQLTPEFFDYVFL---- 499
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   513 GKGSLHRISEvfdcwfESGsMPYAQVHypfENKREFEDAFPADFIAEGIDqtrgwfytlLV---LA------TALFGQ-- 581
Cdd:PRK12300  500 GKGDPEEVSK------KTG-IPKEILE---EMREEFLYWYPVDWRHSGKD---------LIpnhLTffifnhVAIFPEek 560
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   582 -PpfKNVIVNGLVLaSDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSpvvrAE-----NLRFKE-EGVRDVLKDvll 654
Cdd:PRK12300  561 wP--RGIVVNGFVL-LEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSS----AEllqdaDWREKEvESVRRQLER--- 630
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   655 pWYNayrfLIQNVLRLQKEEEIEFLynentvrespnitDRWILSFMQSLIGFFETEMAAYRLYTVVPRLvkFVDILT--N 732
Cdd:PRK12300  631 -FYE----LAKELIEIGGEEELRFI-------------DKWLLSRLNRIIKETTEAMESFQTRDAVQEA--FYELLNdlR 690
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   733 WYvrmnRRRLKGENGmedcvMALETLFSVLLslcRLMAPYTPFLTELMYQNLKVLiDPVSVQDkdtlsihylmLPRVREE 812
Cdd:PRK12300  691 WY----LRRVGEANN-----KVLREVLEIWI---RLLAPFTPHLAEELWHKLGGE-GFVSLEK----------WPEPDES 747
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   813 LIDKKTESAVSQMQSVIElgrvirdrktipikyplkeivvihqdpealkDIKSLEKYIieELNVRKVTLST-DKNKYGIr 891
Cdd:PRK12300  748 KIDEEAELAEEYVKRLIE-------------------------------DIREILKVA--KIKPKKVYIYVaPDWKYEV- 793
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 94721241   892 LRAEPDHMVLGKRLKGAFKAVmtSIKQLSSEELEQFQKtgtIVVEGHELHDEDIRLMYT 950
Cdd:PRK12300  794 LEIAAENGDVKEAIKELMKDE--ELRKHGKEVAKLAQK---IVKEVLKLDKEVRKLILK 847
leuS_bact TIGR00396
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ...
10-870 3.07e-39

leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273057 [Multi-domain]  Cd Length: 842  Bit Score: 158.38  E-value: 3.07e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     10 NFPAEEEKILEFWTEFNCFQecLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHG 89
Cdd:TIGR00396    2 NHIEIEEKWQQKWDENKTFK--VTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     90 LPVE-YEIDKtlGIRgPEDVAKMGITEYNNQCRAivmrysaewkstvsrLGRWIDFDNDYKTLYPQFMESVWWVFKQLYD 168
Cdd:TIGR00396   80 LPAEnAAIKR--GIH-PAKWTYENIANMKKQLQA---------------LGFSYDWDREIATCDPEYYKWTQWIFLELFE 141
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    169 KGLVYRgvKVMPF--------------------STACNTP--------------------LSNFES----HQNYKDVQ-- 202
Cdd:TIGR00396  142 KGLAYV--KEADVnwcpndgtvlaneqvdsdgrSWRGDTPvekkelkqwflkitayaeelLNDLEEldhwPESVKEMQrn 219
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    203 ----DPSVFVTFPLEeDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKikdvargrLLILMEARLSALYKLESDYEILER 278
Cdd:TIGR00396  220 wigkSEGVEITFKIA-DHDEKITVFTTRPDTIFGVTYLALAPEHPLVE--------KAAENNPKVAAFIKKILNKTVAER 290
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    279 FP------GAYLKGKKYRPLfdyflkckENGAFTVLVDNYVKEEEGTGVVHQAPyfgAEDYRvcmDFNIIRKDSLPVCPV 352
Cdd:TIGR00396  291 TKatkekkGVDTGIKAIHPL--------TGEKIPIWVANYVLMEYGTGAVMGVP---AHDER---DFEFAQKYGLPIKPV 356
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    353 dasgcfttevTDFAGQyvkdaDKSIIRTLKEQGRLLVATTFTHSypfcwrsDTPLIYKAVPSWFVrvENMVDQLLRNNDL 432
Cdd:TIGR00396  357 ----------IDPAEK-----DLSLTAAYTEDGVLVNSGEFNGL-------NSSEARNAIIDMLE--KEGKGKRKVNYRL 412
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    433 cywvpelvrekrfgnwlkdaRDWTISRNRYWGTPIPLWVSDDFEEVVCIGS-----VAELEELSGAKISDLHR-ESVDHL 506
Cdd:TIGR00396  413 --------------------RDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEdlpviLPEDVVYDGDGGSPLSRiPEWVNV 472
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    507 TIPSrCGKGSLhRISEVFDCWFESG--SMPYAQVHYP--FENKREFEDAFPADFIAEGIDQT-------RgWFYTLLVLA 575
Cdd:TIGR00396  473 TCPS-CGKPAL-RETDTMDTFAGSSwyYLRYLDPKNTdgPFDKEKAEYWLPVDLYIGGIEHAilhllyaR-FFHKFLRDI 549
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    576 TALFGQPPFKNVIVNGLVLA-------------------------------SDGQKMSKRKKNYPDPVSIIQKYGADALR 624
Cdd:TIGR00396  550 GYVNTKEPFKKLINQGMVLGfyyppngkvpadvlterdekgkdkaggelvyVGYEKMSKSKGNGIDPQEIVESYGADALR 629
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    625 LYLI-NSPVvrAENLRFKEEGVRdvlkdvllpwyNAYRFLiQNVLRLQKEEEIE---FLYNENTVRESPNITDRWILSFM 700
Cdd:TIGR00396  630 LFIMfMGPI--AASLEWNESGLE-----------GARRFL-DRVWNLVYEITGEldaASLTVTALEEAQKELRRDVHKFL 695
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    701 QSLIGFFEtemAAYRLYTVVPRLVKFVDILTNwyvrmnrrrlkgengMEDCVMALETLFSVLlslcRLMAPYTPFLTELM 780
Cdd:TIGR00396  696 KKVTEDLE---KRESFNTAISAMMELLNKLYK---------------AKKEALMLEYLKGFV----TVLSPFAPHLAEEL 753
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    781 YQNLKVLidpvsvqdkdTLSIHYLMLPRVREELIDKktesavSQMQSVIELGRVIRDRKTIPIKYPLKEIVVI-HQDPEA 859
Cdd:TIGR00396  754 WEKLGSE----------PFIIDNAKWPVVDETALVE------DKTLIVVQVNGKFRAKITVPKDADEEQVEELaKQDPEV 817
                          970
                   ....*....|...
gi 94721241    860 LKDI--KSLEKYI 870
Cdd:TIGR00396  818 KKYLenKTIKKVI 830
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
40-178 1.00e-36

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 141.40  E-value: 1.00e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   40 KFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGpedvaKMGITEYNNQ 119
Cdd:cd00668    1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKK-----KTIWIEEFRE 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  120 -CRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKV 178
Cdd:cd00668   76 dPKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP 135
PLN02381 PLN02381
valyl-tRNA synthetase
4-836 4.01e-31

valyl-tRNA synthetase


Pssm-ID: 215214 [Multi-domain]  Cd Length: 1066  Bit Score: 133.10  E-value: 4.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     4 QVPENINFPAEEEKILEFWTEFNCFQECLKQSKhkPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRF 83
Cdd:PLN02381   95 QMAKQYSPSAVEKSWYAWWEKSGYFGADAKSSK--PPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVP 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    84 GWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQcraiVMRYSAEWKSTV----SRLGRWIDFDNDYKTLYPQFMESV 159
Cdd:PLN02381  173 GVDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSE----VWKWKDEYGGTIlnqlRRLGASLDWSRECFTMDEQRSKAV 248
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   160 WWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPS--------------VFVTF--PLEEDETVSLVAw 223
Cdd:PLN02381  249 TEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEV--DYIDIKERTllkvpgydkpvefgVLTSFayPLEGGLGEIVVA- 325
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   224 TTTPWTLPSNLAVCVNPEmqyvkikdvargrllilmEARLSALYKlesdyeileRFPGAYLKGKKYRPLFDyflkckeng 303
Cdd:PLN02381  326 TTRIETMLGDTAIAIHPD------------------DERYKHLHG---------KFAVHPFNGRKLPIICD--------- 369
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   304 afTVLVD-NYvkeeeGTGVVHQAPYFGAEDYRV----CMDF-NIIRKDSlpvcPVDASGCfttevTDFAGQYVKDADKSI 377
Cdd:PLN02381  370 --AILVDpNF-----GTGAVKITPAHDPNDFEVgkrhNLEFiNIFTDDG----KINSNGG-----SEFAGMPRFAAREAV 433
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   378 IRTLKEQGRLLVATTFTHSYPFCWRSD---TPLIYkavPSWFVRVENMVDQLL------RNNDLCYWVPELVREKRfgNW 448
Cdd:PLN02381  434 IEALQKKGLYRGAKNNEMRLGLCSRTNdvvEPMIK---PQWFVNCSSMAKQALdaaidgENKKLEFIPKQYLAEWK--RW 508
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   449 LKDARDWTISRNRYWGTPIPLW---VSDDFEEVVCIGS----VAELEELSGAKISdlhresvdhLTIPSRcgKGSLHRIS 521
Cdd:PLN02381  509 LENIRDWCISRQLWWGHRIPAWyvtLEDDQLKELGSYNdhwvVARNESDALLEAS---------QKFPGK--KFELSQDP 577
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   522 EVFDCWFESGSMPYAQVHYPfENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKM 601
Cdd:PLN02381  578 DVLDTWFSSGLFPLSVLGWP-DDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKM 656
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   602 SKRKKNYPDPVSII----------------------------QKY---------GADALRLYLInSPVVRAENLRFkeeg 644
Cdd:PLN02381  657 SKSLGNVIDPLEVIngisleglhkrleegnldpkelvvakegQKKdfpngiaecGTDALRFALV-SYTAQSDKINL---- 731
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   645 vrDVLKDV-LLPW----YNAYRFLIQNVlrlqkeeEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTV 719
Cdd:PLN02381  732 --DILRVVgYRQWcnklWNAVRFAMSKL-------GDDYTPPATLSVETMPFSCKWILSVLNKAISKTVSSLDAYEFSDA 802
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   720 VPRL-----VKFVDIltnwYVRMNRRRLKGENG--MEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKvlidpvs 792
Cdd:PLN02381  803 ASTVyswwqYQFCDV----FIEAIKPYFAGDNPefASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLP------- 871
                         890       900       910       920
                  ....*....|....*....|....*....|....*....|....*..
gi 94721241   793 vQDKDTLSIHYLML---PRVREELIDKKTESAVSQMQSVIELGRVIR 836
Cdd:PLN02381  872 -QPKDHTRKDSIMIseyPSAVEAWTNEKVEYEMDLVLSTVKCLRSLR 917
Anticodon_1 pfam08264
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ...
693-851 1.77e-23

Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.


Pssm-ID: 400523 [Multi-domain]  Cd Length: 141  Bit Score: 97.47  E-value: 1.77e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    693 DRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGMEdcvMALETLFSVLLSLCRLMAP 771
Cdd:pfam08264    1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFwNDLSDWYLELIKDRLYGEEPDS---RAQTTLYEVLETLLRLLAP 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    772 YTPFLTELMYQNlkvlidpvsvqdkdtLSIHYLMLPrVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIV 851
Cdd:pfam08264   78 FMPFITEELWQK---------------ESIHLAPWP-EDAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
PLN02563 PLN02563
aminoacyl-tRNA ligase
3-626 1.59e-19

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 95.28  E-value: 1.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     3 QQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLP-HYGHILAGTIKDIVTRYAHQSGFHVDR 81
Cdd:PLN02563   74 PAAKRAYPFHEIEPKWQRYWEENRTFRTPDDVDTSKPKFYVLDMFPYPSGAGlHVGHPEGYTATDILARYKRMQGYNVLH 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    82 RFGWDCHGLPVE-YEIDKtlGIRgPEDVAKMGITEYNNQCRAIVMRYsaewkstvsrlgrwiDFDNDYKTLYPQFMESVW 160
Cdd:PLN02563  154 PMGWDAFGLPAEqYAIET--GTH-PKITTLKNIARFRSQLKSLGFSY---------------DWDREISTTEPEYYKWTQ 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   161 WVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFE---------SH-------------------------------QNYKD 200
Cdd:PLN02563  216 WIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEvvdglsergGHpvirkpmrqwmlkitayadrlledlddldwpESIKE 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   201 VQ------------DPSVFVTFPLEEDETVSLvaWTTTPWTLPSNLAVCVNPEMQYVkikdvarGRLLILMEARLSALYK 268
Cdd:PLN02563  296 MQrnwigrsegaelDFSVLDGEGKERDEKITV--YTTRPDTLFGATYLVVAPEHPLL-------SSLTTAEQKEAVEEYV 366
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   269 -LESDYEILER----------FPGAYLKgkkyRPLfdyflkckENGAFTVLVDNYVKEEEGTGVVHQAPyfgAEDYRvcm 337
Cdd:PLN02563  367 dAASRKSDLERtelqkektgvFTGSYAI----NPA--------TGEAIPIWVADYVLGSYGTGAIMAVP---AHDTR--- 428
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   338 DFNIIRKDSLPVCPV---------DASGCFTTEVT---------DFAGQYVKDADKSIIRtlkeqgrllvattfthsypf 399
Cdd:PLN02563  429 DFEFAQKFDLPIKWVvkpadgnedDAEKAYTGEGVivnssssglDINGLSSKEAAKKVIE-------------------- 488
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   400 cwrsdtpliykavpswfvrvenmvdqllrnndlcyWVPELVREKRFGNWlkDARDWTISRNRYWGTPIPLWVSDDFEEVV 479
Cdd:PLN02563  489 -----------------------------------WLEETGNGKKKVNY--KLRDWLFARQRYWGEPIPVVFLEDSGEPV 531
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   480 CIgSVAELEelsgakisdLHRESVDHLTiPSRCGKGSLHRISE---VFDC----WF--ESGSMP--------YAQVHYP- 541
Cdd:PLN02563  532 PV-PESDLP---------LTLPELDDFT-PTGTGEPPLAKAVSwvnTVDPssgkPArrETNTMPqwagscwyYLRFMDPk 600
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   542 -----FENKREfEDAFPADFIAEGIDQ-------TRGW---FYTLLVLATalfgQPPFKNVIVNGLVLA---------SD 597
Cdd:PLN02563  601 nsnalVDKEKE-KYWMPVDLYVGGAEHavlhllyARFWhkvLYDIGVVST----KEPFQCLVNQGMILGeveytafkdSD 675
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 94721241   598 GQ---------------------------------------------KMSKRKKNYPDPVSIIQKYGADALRLY 626
Cdd:PLN02563  676 GEyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLY 749
DUF5915 pfam19302
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ...
870-1033 2.69e-19

Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.


Pssm-ID: 437134 [Multi-domain]  Cd Length: 195  Bit Score: 87.14  E-value: 2.69e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    870 IIEELNVRKVTLSTDKNKYgIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGT--IVVEGH--ELHDEDI 945
Cdd:pfam19302    4 IKEELNVKEVEFGADESEL-VEYSAKPNFPVLGKELGKLMKAAAKEIASLNQMEIQKILDGGTltIDVDGEeiELTSEDL 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    946 RLmytfdQATGgTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEgtyLNSV 1025
Cdd:pfam19302   83 LV-----TRQG-KEGLAVANEGTLTVALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVSGNEM---LEAA 153

                   ....*...
gi 94721241   1026 IESHTEFI 1033
Cdd:pfam19302  154 IEKFEDYI 161
Anticodon_Ia_Val cd07962
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ...
657-784 3.55e-17

Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.


Pssm-ID: 153416 [Multi-domain]  Cd Length: 135  Bit Score: 79.14  E-value: 3.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  657 YNAYRFLIQNvlrlqkeeeIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYV 735
Cdd:cd07962   17 WNAARFVLMN---------LEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwNDFCDWYL 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 94721241  736 RMNRRRLKGENGMEDCVmALETLFSVLLSLCRLMAPYTPFLTELMYQNL 784
Cdd:cd07962   88 ELVKPRLYGEDEEEKKA-ARATLYYVLETILRLLHPFMPFITEELWQRL 135
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ...
453-784 2.99e-15

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440261 [Multi-domain]  Cd Length: 826  Bit Score: 80.87  E-value: 2.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  453 RDWTISRNRYWGTPIPLWVSDDfeevvCiGSVA-----------ELEELSGAKISDL--HRESVdHLTIPsRCGKgSLHR 519
Cdd:COG0495  420 RDWLISRQRYWGEPIPIIHCED-----C-GVVPvpedqlpvelpEDVDFDPTGGSPLarAPEWV-NVTCP-KCGG-PARR 490
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  520 ISEVFDCWFESgS---MPYAQVHYpfenkrefeDAFPADFIAE----GIDQ--------------TRgwFYTLLVLATAL 578
Cdd:COG0495  491 ETDTMDTFVDS-SwyyLRYTDPHN---------DEAPFDPEAAnywlPVDQyiggiehailhllyAR--FFTKVLRDLGL 558
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  579 FGQP-PFKNVIVNGLV--LASDG------QKMSKRKKNYPDPVSIIQKYGADALRLYLI-NSPVVRaeNLRFKEEGVRdv 648
Cdd:COG0495  559 VSFDePFKRLLTQGMVleVGKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMfAGPPER--DLEWSDSGVE-- 634
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  649 lkdvllpwyNAYRFLiQNVLRLQKEEEIEFLYNENTvresPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVD 728
Cdd:COG0495  635 ---------GAYRFL-NRVWRLVVDEAEALKLDVAD----LSEADKELRRALHKTIKKVTEDIERLRFNTAIAALMELVN 700
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 94721241  729 ILTnwyvrmnrrRLKGENGMEDCVM--ALETlfsvllsLCRLMAPYTPFLTELMYQNL 784
Cdd:COG0495  701 ALY---------KAKDSGEADRAVLreALET-------LVLLLAPFAPHIAEELWERL 742
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
48-175 1.61e-14

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 76.13  E-value: 1.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTlgIRGPEDvakmgITEYNnqcraivmry 127
Cdd:cd00812    9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKI--GRDPED-----WTEYN---------- 71
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 94721241  128 SAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRG 175
Cdd:cd00812   72 IKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKK 119
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
413-628 1.98e-12

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 69.58  E-value: 1.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  413 PSWFVRVENMVDQLLRnndlcywVPELVReKRFGNWLKdardwtISRNRYWGTPIPL-WVSDDFeevvcIGSvaeleels 491
Cdd:cd00812  139 TEWKEKLLKDLEKLDG-------WPEEVR-AMQENWIG------CSRQRYWGTPIPWtDTMESL-----SDS-------- 191
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  492 gakisdlhresvdhltipsrcgkgslhrisevfdCWFESGsmpYAQVHYPF--------ENKREFEDAFPADFIAEGIDQ 563
Cdd:cd00812  192 ----------------------------------TWYYAR---YTDAHNLEqpyegdleFDREEFEYWYPVDIYIGGKEH 234
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  564 -----TRGWFYTLLVLATALFGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI 628
Cdd:cd00812  235 apnhlLYSRFNHKALFDEGLVTDEPPKGLIVQGMVLL-EGEKMSKSKGNVVTPDEAIKKYGADAARLYIL 303
MetG COG0143
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ...
48-628 9.64e-12

Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439913 [Multi-domain]  Cd Length: 544  Bit Score: 68.99  E-value: 9.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrRF--GWDCHGLPVEyeidktlgIRGpedvAKMGITEynnqcRAIVM 125
Cdd:COG0143   10 PYANGPPHIGHLYTYIPADILARYQRLRGHDV--LFvtGTDEHGTKIE--------LAA----EKEGITP-----QELVD 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  126 RYSAEWKSTVSRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYrgvkvmpfstacntplsnfeshqnykdvqdps 205
Cdd:COG0143   71 RIHAEFKELFEKLG--ISFDNFIRTTSPEHKELVQEIFQRLYDNGDIY-------------------------------- 116
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  206 vfvtfpleedetvslvawtttpwtlpsnlavcvnpemqyvkikdvargrllilmearlsalyklESDYEilerfpGAYlk 285
Cdd:COG0143  117 ----------------------------------------------------------------KGEYE------GWY-- 124
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  286 gkkyrplfdyflkCKENGAFtvLVDNYVkeeEGTgvvhqAPYFGAEDYRvcmdfniirKDSLPVCpvdasgcfttevtdf 365
Cdd:COG0143  125 -------------CPECERF--LPDRYV---EGT-----CPKCGAEDAY---------GDQCENC--------------- 157
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  366 agqyvkdadksiirtlkeqGRLLVATTFTHsyPFCWRSDTPLIYKAVPSWFVRVENMVDQLL----RNNDlcyWVPELVR 441
Cdd:COG0143  158 -------------------GATLEPTELIN--PRSAISGAPPELREEEHYFFRLSKYQDRLLewieENPD---IQPEVRN 213
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  442 EKRfgNWLKDA-RDWTISRNRYWGTPIPlwvsddfeevvcigsvaeleelsGAKisdlhresvDHltipsrcgkgslhri 520
Cdd:COG0143  214 EVL--SWLKEGlQDLSISRDFDWGIPVP-----------------------GDP---------GK--------------- 244
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  521 seVFDCWFE------SGSMPYAQVHYPFENkreFEDAFPAD------FIaeGIDQTRgwFYTLL---VLATAlfGQPPFK 585
Cdd:COG0143  245 --VFYVWFDaligyiSATKGYADDRGLPED---FEKYWPAPdtelvhFI--GKDIIR--FHAIIwpaMLMAA--GLPLPK 313
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|...
gi 94721241  586 NVIVNGLVLaSDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI 628
Cdd:COG0143  314 KVFAHGFLT-VEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLL 355
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
48-190 3.64e-11

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 66.54  E-value: 3.64e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241     48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrRF--GWDCHGLPVEYEIDKtLGIrGPEDVakmgiteynnqcraiVM 125
Cdd:pfam09334    8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDV--LFvcGTDEHGTPIELKAEK-EGI-TPEEL---------------VD 68
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 94721241    126 RYSAEWKSTVSRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLS 190
Cdd:pfam09334   69 RYHEIHREDFKKFN--ISFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLP 131
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
377-628 5.85e-09

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 59.08  E-value: 5.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  377 IIRTLKEQGRLLVATtftHSYPFCWRSDTPL-IYKAVPSWFVRVENMVDQL---LRNNDLCYWvPELVReKRFGNWLKDA 452
Cdd:cd00814  104 FFKKLYENGYIYEGE---YEGLYCVSCERFLpEWREEEHYFFRLSKFQDRLlewLEKNPDFIW-PENAR-NEVLSWLKEG 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  453 -RDWTISR-NRYWGTPIPlwvsdDFEevvcigsvaeleelsgakisdlhresvDHltipsrcgkgslhriseVFDCWFE- 529
Cdd:cd00814  179 lKDLSITRdLFDWGIPVP-----LDP---------------------------GK-----------------VIYVWFDa 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  530 -----SGSMPYAQvhyPFENKREFEDAFPAD--FIaeGIDQTRgwFYTLL---VLATAlfGQPPFKNVIVNGLVLAsDGQ 599
Cdd:cd00814  210 ligyiSATGYYNE---EWGNSWWWKDGWPELvhFI--GKDIIR--FHAIYwpaMLLGA--GLPLPTRIVAHGYLTV-EGK 279
                        250       260
                 ....*....|....*....|....*....
gi 94721241  600 KMSKRKKNYPDPVSIIQKYGADALRLYLI 628
Cdd:cd00814  280 KMSKSRGNVVDPDDLLERYGADALRYYLL 308
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
540-628 3.83e-08

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 57.89  E-value: 3.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   540 YPFENKREFEDAFPADFIAEGIDQTRgwFYT------LLVLatalfGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVS 613
Cdd:PRK12267  241 YGSDDDELFKKFWPADVHLVGKDILR--FHAiywpimLMAL-----GLPLPKKVFAHGWWLM-KDGKMSKSKGNVVDPEE 312
                          90
                  ....*....|....*
gi 94721241   614 IIQKYGADALRLYLI 628
Cdd:PRK12267  313 LVDRYGLDALRYYLL 327
Anticodon_Ia_like cd07375
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ...
657-773 1.20e-07

Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.


Pssm-ID: 153408 [Multi-domain]  Cd Length: 117  Bit Score: 51.35  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  657 YNAYRFLIQNVLrlqkeeeiefLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILtNWYVR 736
Cdd:cd07375   15 YRLLSFFRKALG----------GTQPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL-NWYLD 83
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 94721241  737 MNRRRLKGENGMEDCVMALETLFSVLLslcRLMAPYT 773
Cdd:cd07375   84 ELKPALQTEELREAVLAVLRAALVVLT---KLLAPFT 117
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
398-628 2.83e-07

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 54.89  E-value: 2.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   398 PFCWRSDTPLIYKAVPSWFVRVENMVDQLL---RNNdlcywvPELV----REKRFGNWLKD-ARDWTISRNRY-WGTPIP 468
Cdd:PRK11893  142 YRCPPTGAPVEWVEEESYFFRLSKYQDKLLelyEAN------PDFIqpasRRNEVISFVKSgLKDLSISRTNFdWGIPVP 215
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   469 lwvSDDfeevvcigsvaeleelsgakisdlhresvdhltipsrcgkgsLHRISEVFD--CWFESGSM-PYAQVhypfENK 545
Cdd:PRK11893  216 ---GDP------------------------------------------KHVIYVWFDalTNYLTALGyPDDEE----LLA 246
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241   546 REFEDAFPAD--FIaeGIDQTR----GWfytlLVLATALfGQPPFKNVIVNG-LVLasDGQKMSKRKKNYPDPVSIIQKY 618
Cdd:PRK11893  247 ELFNKYWPADvhLI--GKDILRfhavYW----PAFLMAA-GLPLPKRVFAHGfLTL--DGEKMSKSLGNVIDPFDLVDEY 317
                         250
                  ....*....|
gi 94721241   619 GADALRLYLI 628
Cdd:PRK11893  318 GVDAVRYFLL 327
Anticodon_Ia_Ile_BEm cd07960
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ...
693-828 2.13e-06

Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153414 [Multi-domain]  Cd Length: 180  Bit Score: 49.45  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  693 DRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFV-DILTNWYV-----RM-------NRRRlkgengmedcvMALETLF 759
Cdd:cd07960   46 DRYALHRLNELIKEVREAYENYEFHKVYQALNNFCtVDLSAFYLdiikdRLycdakdsLERR-----------SAQTVLY 114
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 94721241  760 SVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVqdkdtlsiHYLMLPRVREELIDKKTESAVSQMQSV 828
Cdd:cd07960  115 HILDALLKLLAPILPFTAEEVWEHLPGEKKEESV--------FLEDWPELPEEWKDEELEEKWEKLLAL 175
CysRS_core cd00672
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ...
572-630 6.44e-05

catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173899 [Multi-domain]  Cd Length: 213  Bit Score: 45.65  E-value: 6.44e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 94721241  572 LVLATALFGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINS 630
Cdd:cd00672  147 IAQSEAATGKPFARYWLHTGHLTI-DGEKMSKSLGNFITVRDALKKYDPEVLRLALLSS 204
Anticodon_Ia_Leu_AEc cd07959
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ...
668-784 1.43e-04

Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153413 [Multi-domain]  Cd Length: 117  Bit Score: 42.58  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241  668 LRLQKEEE-IEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLvkFVDILT--NWYVRMnrrrlkG 744
Cdd:cd07959   11 LRLERFYElAEELIETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEG--LYELQNdlDWYRER------G 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 94721241  745 ENGMEDCVmaletLFSVLLSLCRLMAPYTPFLTELMYQNL 784
Cdd:cd07959   83 GAGMNKDL-----LRRFIEVWTRLLAPFAPHLAEEIWHEL 117
metG PRK00133
methionyl-tRNA synthetase; Reviewed
48-174 3.12e-04

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 234655 [Multi-domain]  Cd Length: 673  Bit Score: 45.14  E-value: 3.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94721241    48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVdrRF--GWDCHGLPVEyeidktlgIRGpedvAKMGITEynnqcRAIVM 125
Cdd:PRK00133   11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEV--LFvcADDAHGTPIM--------LKA----EKEGITP-----EELIA 71
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 94721241   126 RYSAEWKSTVSRLGrwIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYR 174
Cdd:PRK00133   72 RYHAEHKRDFAGFG--ISFDNYGSTHSEENRELAQEIYLKLKENGYIYE 118
tRNA-synt_1e pfam01406
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ...
576-650 4.40e-04

tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.


Pssm-ID: 396128 [Multi-domain]  Cd Length: 301  Bit Score: 43.90  E-value: 4.40e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 94721241    576 TALFGQPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVSIIQKYGADALRLYLI----NSPvvraenLRFKEEGVRDVLK 650
Cdd:pfam01406  230 EAAFDKQLANYWLHNGHVMI-DGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLsvhyRSP------LDFSEELLEQAKS 301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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