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Conserved domains on  [gi|4504901|ref|NP_002259|]
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importin subunit alpha-3 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
11-513 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 520.60  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901   11 RLKNFKNKGR-DLETMRRQRNEVVVELRKNKRDEHLLKRRN-VPHEDICEDSDIDGDYRVQNtSLEAIVQNASSDNQGIQ 88
Cdd:COG5064  10 RRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNlADVSEEAESSFIPMEQQFYS-ELPQLTQQLFSDDIEQQ 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901   89 LSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHS 168
Cdd:COG5064  89 LQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSS 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  169 PHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPAL 247
Cdd:COG5064 169 TEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPIL 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  248 CVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDA 327
Cdd:COG5064 249 AKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGA 328

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  328 LSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISG--RKDQVA 405
Cdd:COG5064 329 LKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGlnRPDIIR 408

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  406 YLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAE-DEAETIGNL------IEECGGLEKIEQLQNHENEDIYKLAY 478
Cdd:COG5064 409 YLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqDRLRYGKNIniyavyVEKAGGMDAIHGLQDSVNRTIYDKAY 488

                       490       500       510
                ....*....|....*....|....*....|....*
gi 4504901  479 EIIDQFFSSDDIDEDpsLVPEAIqGGTFGFNSSAN 513
Cdd:COG5064 489 SIIEKFFGEEDAVDE--LAPETA-GNTFTFGSNVN 520
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
11-513 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 520.60  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901   11 RLKNFKNKGR-DLETMRRQRNEVVVELRKNKRDEHLLKRRN-VPHEDICEDSDIDGDYRVQNtSLEAIVQNASSDNQGIQ 88
Cdd:COG5064  10 RRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNlADVSEEAESSFIPMEQQFYS-ELPQLTQQLFSDDIEQQ 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901   89 LSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHS 168
Cdd:COG5064  89 LQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSS 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  169 PHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPAL 247
Cdd:COG5064 169 TEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPIL 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  248 CVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDA 327
Cdd:COG5064 249 AKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGA 328

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  328 LSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISG--RKDQVA 405
Cdd:COG5064 329 LKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGlnRPDIIR 408

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  406 YLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAE-DEAETIGNL------IEECGGLEKIEQLQNHENEDIYKLAY 478
Cdd:COG5064 409 YLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqDRLRYGKNIniyavyVEKAGGMDAIHGLQDSVNRTIYDKAY 488

                       490       500       510
                ....*....|....*....|....*....|....*
gi 4504901  479 EIIDQFFSSDDIDEDpsLVPEAIqGGTFGFNSSAN 513
Cdd:COG5064 489 SIIEKFFGEEDAVDE--LAPETA-GNTFTFGSNVN 520
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 11-93 1.26e-29

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 111.09  E-value: 1.26e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901     11 RLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGdyrvQNTSLEAIVQNASSDNQGIQLS 90
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAESQ----LLESLPEMVQGVNSDDPELQLE 76


                  ...
gi 4504901     91 AVQ 93
Cdd:pfam01749  77 ATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 274-312 2.05e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.82  E-value: 2.05e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4504901     274 NEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIV 312
Cdd:smart00185   2 DENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 60-186 6.14e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.78  E-value: 6.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901     60 SDIDGDYR--VQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPpIDDLIKSGILPILVHCLERDDNPSLQFEAAW 137
Cdd:PLN03200  176 GSTDGFWSatLEAGGVDILVKLLSSGNSDAQANAASLLARLMMAFESS-ISKVLDAGAVKQLLKLLGQGNEVSVRAEAAG 254

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 4504901    138 ALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPH----QNVCEQ-----AVWALGNIIG 186
Cdd:PLN03200  255 ALEALSSQSKEAKQAIADAGGIPALINATVAPSkefmQGEFAQalqenAMGALANICG 312
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
11-513 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 520.60  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901   11 RLKNFKNKGR-DLETMRRQRNEVVVELRKNKRDEHLLKRRN-VPHEDICEDSDIDGDYRVQNtSLEAIVQNASSDNQGIQ 88
Cdd:COG5064  10 RRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNlADVSEEAESSFIPMEQQFYS-ELPQLTQQLFSDDIEQQ 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901   89 LSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHS 168
Cdd:COG5064  89 LQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSS 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  169 PHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPAL 247
Cdd:COG5064 169 TEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPIL 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  248 CVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDA 327
Cdd:COG5064 249 AKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGA 328

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  328 LSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISG--RKDQVA 405
Cdd:COG5064 329 LKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGlnRPDIIR 408

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  406 YLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAE-DEAETIGNL------IEECGGLEKIEQLQNHENEDIYKLAY 478
Cdd:COG5064 409 YLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqDRLRYGKNIniyavyVEKAGGMDAIHGLQDSVNRTIYDKAY 488

                       490       500       510
                ....*....|....*....|....*....|....*
gi 4504901  479 EIIDQFFSSDDIDEDpsLVPEAIqGGTFGFNSSAN 513
Cdd:COG5064 489 SIIEKFFGEEDAVDE--LAPETA-GNTFTFGSNVN 520
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 11-93 1.26e-29

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 111.09  E-value: 1.26e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901     11 RLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGdyrvQNTSLEAIVQNASSDNQGIQLS 90
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAESQ----LLESLPEMVQGVNSDDPELQLE 76


                  ...
gi 4504901     91 AVQ 93
Cdd:pfam01749  77 ATQ 79
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 451-499 1.88e-21

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 87.26  E-value: 1.88e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 4504901    451 NLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPE 499
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEEDDENLAPE 49
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 146-184 7.78e-11

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 57.08  E-value: 7.78e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4504901    146 TSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNI 184
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 357-396 6.06e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 54.38  E-value: 6.06e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 4504901    357 NQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLT 396
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 274-313 6.30e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 54.38  E-value: 6.30e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 4504901    274 NEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVT 313
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 129-184 9.80e-10

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 54.30  E-value: 9.80e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4504901    129 PSLQFEAAWALTNIASGTSEQTQAVVQsNAVPLFLRLLHSPHQNVCEQAVWALGNI 184
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVP-ELLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 274-312 2.05e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.82  E-value: 2.05e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4504901     274 NEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIV 312
Cdd:smart00185   2 DENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 146-184 3.52e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.43  E-value: 3.52e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4504901     146 TSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNI 184
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 104-144 1.64e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 50.53  E-value: 1.64e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 4504901    104 NPPIDDLIKSGILPILVHCLeRDDNPSLQFEAAWALTNIAS 144
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
116-311 5.53e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 51.94  E-value: 5.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  116 LPILVHCLeRDDNPSLQFEAAWALTNIASGTseqtqavvqsnAVPLFLRLLHSPHQNVCEQAVWALGNIigdgpqcrdyv 195
Cdd:COG1413  18 VPALIAAL-ADEDPDVRAAAARALGRLGDPR-----------AVPALLEALKDPDPEVRAAAAEALGRI----------- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  196 islgvvkpllsfispsipitflrnvtwvmvnlcrhKDPpppmetiqEILPALCVLIHHTDVNILVDTVWALSYLTDAgne 275
Cdd:COG1413  75 -----------------------------------GDP--------EAVPALIAALKDEDPEVRRAAAEALGRLGDP--- 108

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 4504901  276 qiqmvidsGIVPHLVPLLSHQEVKVQTAALRAVGNI 311
Cdd:COG1413 109 --------AAVPALLEALKDPDWEVRRAAARALGRL 136
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 103-144 8.48e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 8.48e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 4504901     103 RNPPIDDLIKSGILPILVHCLeRDDNPSLQFEAAWALTNIAS 144
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELL-KSEDEEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
227-395 2.03e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.01  E-value: 2.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  227 LCRHKDPpppmetiqEILPALCVLIHHTDVNILVDTVWALSYLTDAGneqiqmvidsgIVPHLVPLLSHQEVKVQTAALR 306
Cdd:COG1413   9 LGRLGDP--------AAVPALIAALADEDPDVRAAAARALGRLGDPR-----------AVPALLEALKDPDPEVRAAAAE 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901  307 AVGNIvtGTDEQTQVVLncdalshfpALLTHPKEKINKEAVWFLSNITagnqqqvqaviDANLVPMIIHLLDKGDFGTQK 386
Cdd:COG1413  70 ALGRI--GDPEAVPALI---------AALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEALKDPDWEVRR 127


                ....*....
gi 4504901  387 EAAWAISNL 395
Cdd:COG1413 128 AAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
72-184 3.83e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 49.24  E-value: 3.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901   72 SLEAIVQNASSDNQGIQLSAVQAARKLLSSDrnppiddliksgILPILVHCLeRDDNPSLQFEAAWALTNIASgtseqtq 151
Cdd:COG1413  48 AVPALLEALKDPDPEVRAAAAEALGRIGDPE------------AVPALIAAL-KDEDPEVRRAAAEALGRLGD------- 107

                        90       100       110
                ....*....|....*....|....*....|...
gi 4504901  152 avvqSNAVPLFLRLLHSPHQNVCEQAVWALGNI 184
Cdd:COG1413 108 ----PAAVPALLEALKDPDWEVRRAAARALGRL 136
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 357-396 3.91e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 3.91e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4504901     357 NQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLT 396
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 315-355 6.03e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 6.03e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 4504901    315 TDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITA 355
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 116-184 8.85e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 46.95  E-value: 8.85e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504901    116 LPILVHCLERDDNPSLQFEAAWALTNIASgtseqtqavvqSNAVPLFLRLLHSPHQNVCEQAVWALGNI 184
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI 58
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 315-355 1.51e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 44.73  E-value: 1.51e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 4504901     315 TDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITA 355
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
72-184 9.17e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.39  E-value: 9.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901   72 SLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKsgilpilvhclerDDNPSLQFEAAWALTNIASgtseqtq 151
Cdd:COG1413  17 AVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALK-------------DPDPEVRAAAAEALGRIGD------- 76

                        90       100       110
                ....*....|....*....|....*....|...
gi 4504901  152 avvqSNAVPLFLRLLHSPHQNVCEQAVWALGNI 184
Cdd:COG1413  77 ----PEAVPALIAALKDEDPEVRRAAAEALGRL 105
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 402-438 1.43e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.06  E-value: 1.43e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 4504901    402 DQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNI 438
Cdd:pfam00514   3 ENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 402-438 2.57e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 2.57e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 4504901     402 DQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNI 438
Cdd:smart00185   3 ENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 232-271 5.29e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 5.29e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 4504901    232 DPPPPMETIQE-ILPALCVLIHHTDVNILVDTVWALSYLTD 271
Cdd:pfam00514   1 SPENKQAVIEAgAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 60-186 6.14e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.78  E-value: 6.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901     60 SDIDGDYR--VQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPpIDDLIKSGILPILVHCLERDDNPSLQFEAAW 137
Cdd:PLN03200  176 GSTDGFWSatLEAGGVDILVKLLSSGNSDAQANAASLLARLMMAFESS-ISKVLDAGAVKQLLKLLGQGNEVSVRAEAAG 254

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 4504901    138 ALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPH----QNVCEQ-----AVWALGNIIG 186
Cdd:PLN03200  255 ALEALSSQSKEAKQAIADAGGIPALINATVAPSkefmQGEFAQalqenAMGALANICG 312
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 75-502 3.98e-03

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 39.91  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901     75 AIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGIlpilvhcleRDDNPSLQFEAAWALTNIASGTSEQ----- 149
Cdd:pfam01602  83 SIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLL---------VDRSPYVRKKAALAILKLYRKSPDLvrdfv 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901    150 ---------TQAVVQSNAVPLFLRLLHSPHQNVceQAVWALGNIIGDGpqcrdyvisLGVVKPLLSfispsipITFLRnv 220
Cdd:pfam01602 154 pelkellsdKDPGVQSAAVALLYEICKNDRLYL--KLLPLLFRRLCNL---------LGVLNPWLQ-------VKILR-- 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901    221 twVMVNLCRHkDPPPPMETIQEILPalcvLIHHTDVNILVDTVWALSYLtDAGNEQIQMvidsgIVPHLVPLLSHQEVKV 300
Cdd:pfam01602 214 --LLTRLAPL-DPLLPKELLEDLLN----LLQNSNNAVLYETANTIVHL-APAPELIVL-----AVNALGRLLSSPDENL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901    301 QTAALRAVGNIVTGTdeqTQVVLNCDALSHFpaLLTHPKEKINKEAVWFLSNItaGNQQQVQAVIDAnlvpMIIHLLDKG 380
Cdd:pfam01602 281 RYVALRNLNKIVMKE---PKAVQHLDLIIFC--LKTDDDISIRLRALDLLYAL--VNESNVKEIVKE----LLKYVHEIA 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504901    381 DFGTQKEAAWAISNLTI-SGRKdqvayliQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDE-AETIGNLIEecgG 458
Cdd:pfam01602 350 DPDFKIELVRAIGRLAEkFPTD-------AEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPELrEYILEHLCE---L 419

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 4504901    459 LEKIEQlqnhenEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQ 502
Cdd:pfam01602 420 LEDIES------PEALAAALWILGEYGELIPNGSSPPDLLRSIL 457
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 189-229 6.99e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 34.35  E-value: 6.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 4504901    189 PQCRDYVISLGVVKPLLSFI-SPSIPItfLRNVTWVMVNLCR 229
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLsSPDEEV--QEEAAWALSNLAA 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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