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Conserved domains on  [gi|167555125|ref|NP_002324|]
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low-density lipoprotein receptor-related protein 3 precursor [Homo sapiens]

Protein Classification

CUB and LDLa domain-containing protein( domain architecture ID 10035864)

CUB and LDLa (low-density lipoprotein receptor class A) domain-containing protein similar to Homo sapiens low-density lipoprotein receptor-related protein 12 which may be involved in the internalization of lipophilic molecules and/or signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 43-156 3.22e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 115.20  E-value: 3.22e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125  43 CSGKLeqHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLL--GPAAPPRQEAfRLC 120
Cdd:cd00041    1 CGGTL--TASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydGPSTSSPLLG-RFC 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 167555125 121 GSAIPPAFISARDHVWIFFHSDasSSGQAQGFRLSY 156
Cdd:cd00041   78 GSTLPPPIISSGNSLTVRFRSD--SSVTGRGFKATY 111
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 455-489 1.31e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 1.31e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 167555125 455 CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 166-200 1.81e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.81e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 167555125 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNC 200
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 254-364 2.08e-09

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 55.88  E-value: 2.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125 254 CGRRL-GSFYGSFASPDLFGAarGPSDLHCTWLVDTQDSRRVLLQ---LELRLGYD---DYVQVYEGLGERGDRLLQtls 326
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPNN--YPNNLNCVWTIEAPPGYRIRLTfedFDLESSPNcsyDYLEIYDGPSTSSPLLGR--- 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 167555125 327 YRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQV 364
Cdd:cd00041   76 FCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 212-249 4.93e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 4.93e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 167555125 212 CPGGTFPCsgaRSTRCLPVERRCDGLQDCGDGSDEAGC 249
Cdd:cd00112    1 CPPNEFRC---ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 416-452 6.65e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.65  E-value: 6.65e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 167555125 416 CPPDQYPCegGSGLCYTPADRCNNQKSCPDGADEKNC 452
Cdd:cd00112    1 CPPNEFRC--ANGRCIPSSWVCDGEDDCGDGSDEENC 35
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 615-757 6.12e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125  615 PRAPRGQIPLLTAARPSQTVLGDgflQPAPGAAPDPPAPLMDTGSTRAAGDRPPSAPGRAPEVGPSGPPLPSglrDPECR 694
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWD---PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPS---LPLGG 2854

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 167555125  695 PVDKDRKVCREPLVDGPAPADA-PREPCSAQDPHPQV--STASSTLGPHSPEPLgvcRNPPPPCSP 757
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPAaPARPPVRRLARPAVsrSTESFALPPDQPERP---PQPQAPPPP 2917
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 43-156 3.22e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 115.20  E-value: 3.22e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125  43 CSGKLeqHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLL--GPAAPPRQEAfRLC 120
Cdd:cd00041    1 CGGTL--TASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydGPSTSSPLLG-RFC 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 167555125 121 GSAIPPAFISARDHVWIFFHSDasSSGQAQGFRLSY 156
Cdd:cd00041   78 GSTLPPPIISSGNSLTVRFRSD--SSVTGRGFKATY 111
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 55-156 8.04e-23

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 93.61  E-value: 8.04e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125    55 GVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLL--GPAAPPRQEAfRLCGSAIPPAFI-SA 131
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydGPSASSPLLG-RFCGSEAPPPVIsSS 79

                           90       100
                   ....*....|....*....|....*
gi 167555125   132 RDHVWIFFHSDasSSGQAQGFRLSY 156
Cdd:smart00042  80 SNSLTLTFVSD--SSVQKRGFSARY 102
CUB pfam00431
CUB domain;
43-156 7.48e-22

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 91.20  E-value: 7.48e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125   43 CSGKLeqhTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWL-----------LLGpaap 111
Cdd:pfam00431   1 CGGVL---TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVeirdgpsasspLLG---- 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 167555125  112 prqeafRLCGSAIPPAFISARDHVWIFFHSDAssSGQAQGFRLSY 156
Cdd:pfam00431  74 ------RFCGSGIPEDIVSSSNQMTIKFVSDA--SVQKRGFKATY 110
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 455-489 1.31e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 1.31e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 167555125 455 CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 166-200 1.81e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.81e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 167555125 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNC 200
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 455-486 5.03e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 5.03e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 167555125   455 CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 254-364 2.08e-09

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 55.88  E-value: 2.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125 254 CGRRL-GSFYGSFASPDLFGAarGPSDLHCTWLVDTQDSRRVLLQ---LELRLGYD---DYVQVYEGLGERGDRLLQtls 326
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPNN--YPNNLNCVWTIEAPPGYRIRLTfedFDLESSPNcsyDYLEIYDGPSTSSPLLGR--- 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 167555125 327 YRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQV 364
Cdd:cd00041   76 FCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
455-489 3.12e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 3.12e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 167555125  455 CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 166-197 3.56e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.56e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 167555125   166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDE 197
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
166-200 6.44e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 6.44e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 167555125  166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNC 200
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 212-249 4.93e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 4.93e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 167555125 212 CPGGTFPCsgaRSTRCLPVERRCDGLQDCGDGSDEAGC 249
Cdd:cd00112    1 CPPNEFRC---ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 212-246 9.43e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 9.43e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 167555125   212 CPGGTFPCsgaRSTRCLPVERRCDGLQDCGDGSDE 246
Cdd:smart00192   2 CPPGEFQC---DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
212-249 7.99e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.01  E-value: 7.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 167555125  212 CPGGTFPCsgaRSTRCLPVERRCDGLQDCGDGSDEAGC 249
Cdd:pfam00057   3 CSPNEFQC---GSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 416-452 6.65e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.65  E-value: 6.65e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 167555125 416 CPPDQYPCegGSGLCYTPADRCNNQKSCPDGADEKNC 452
Cdd:cd00112    1 CPPNEFRC--ANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 277-362 1.50e-04

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 41.61  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125   277 PSDLHCTWLVDTQDSRRVLLQ---LELRLGYD---DYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAaqGRLTVAYHAR 350
Cdd:smart00042  13 PNNLDCVWTIRAPPGYRIELQftdFDLESSDNceyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS--NSLTLTFVSD 90

                           90
                   ....*....|..
gi 167555125   351 ARSAGHGFNATY 362
Cdd:smart00042  91 SSVQKRGFSARY 102
CUB pfam00431
CUB domain;
254-362 5.89e-04

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 39.97  E-value: 5.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125  254 CGRRLGSFYGSFASPDlfGAARGPSDLHCTWLVDTQDSRRVLLQ---LEL---RLGYDDYVQVYEGLGERGDRLlqtLSY 327
Cdd:pfam00431   1 CGGVLTDSSGSISSPN--YPNPYPPNKDCVWLIRAPPGFRVKLTfqdFELedhDECGYDYVEIRDGPSASSPLL---GRF 75

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 167555125  328 RSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATY 362
Cdd:pfam00431  76 CGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
PHA03247 PHA03247
large tegument protein UL36; Provisional
 615-757 6.12e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125  615 PRAPRGQIPLLTAARPSQTVLGDgflQPAPGAAPDPPAPLMDTGSTRAAGDRPPSAPGRAPEVGPSGPPLPSglrDPECR 694
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWD---PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPS---LPLGG 2854

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 167555125  695 PVDKDRKVCREPLVDGPAPADA-PREPCSAQDPHPQV--STASSTLGPHSPEPLgvcRNPPPPCSP 757
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPAaPARPPVRRLARPAVsrSTESFALPPDQPERP---PQPQAPPPP 2917
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 43-156 3.22e-30

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 115.20  E-value: 3.22e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125  43 CSGKLeqHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLL--GPAAPPRQEAfRLC 120
Cdd:cd00041    1 CGGTL--TASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydGPSTSSPLLG-RFC 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 167555125 121 GSAIPPAFISARDHVWIFFHSDasSSGQAQGFRLSY 156
Cdd:cd00041   78 GSTLPPPIISSGNSLTVRFRSD--SSVTGRGFKATY 111
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 55-156 8.04e-23

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 93.61  E-value: 8.04e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125    55 GVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLL--GPAAPPRQEAfRLCGSAIPPAFI-SA 131
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydGPSASSPLLG-RFCGSEAPPPVIsSS 79

                           90       100
                   ....*....|....*....|....*
gi 167555125   132 RDHVWIFFHSDasSSGQAQGFRLSY 156
Cdd:smart00042  80 SNSLTLTFVSD--SSVQKRGFSARY 102
CUB pfam00431
CUB domain;
43-156 7.48e-22

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 91.20  E-value: 7.48e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125   43 CSGKLeqhTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWL-----------LLGpaap 111
Cdd:pfam00431   1 CGGVL---TDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVeirdgpsasspLLG---- 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 167555125  112 prqeafRLCGSAIPPAFISARDHVWIFFHSDAssSGQAQGFRLSY 156
Cdd:pfam00431  74 ------RFCGSGIPEDIVSSSNQMTIKFVSDA--SVQKRGFKATY 110
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 455-489 1.31e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 1.31e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 167555125 455 CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 166-200 1.81e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.81e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 167555125 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNC 200
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 455-486 5.03e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 5.03e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 167555125   455 CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 254-364 2.08e-09

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 55.88  E-value: 2.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125 254 CGRRL-GSFYGSFASPDLFGAarGPSDLHCTWLVDTQDSRRVLLQ---LELRLGYD---DYVQVYEGLGERGDRLLQtls 326
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPNN--YPNNLNCVWTIEAPPGYRIRLTfedFDLESSPNcsyDYLEIYDGPSTSSPLLGR--- 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 167555125 327 YRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQV 364
Cdd:cd00041   76 FCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
455-489 3.12e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 3.12e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 167555125  455 CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 166-197 3.56e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 3.56e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 167555125   166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDE 197
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
166-200 6.44e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 6.44e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 167555125  166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNC 200
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 212-249 4.93e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 4.93e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 167555125 212 CPGGTFPCsgaRSTRCLPVERRCDGLQDCGDGSDEAGC 249
Cdd:cd00112    1 CPPNEFRC---ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 212-246 9.43e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 9.43e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 167555125   212 CPGGTFPCsgaRSTRCLPVERRCDGLQDCGDGSDE 246
Cdd:smart00192   2 CPPGEFQC---DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
212-249 7.99e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.01  E-value: 7.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 167555125  212 CPGGTFPCsgaRSTRCLPVERRCDGLQDCGDGSDEAGC 249
Cdd:pfam00057   3 CSPNEFQC---GSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 416-452 6.65e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.65  E-value: 6.65e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 167555125 416 CPPDQYPCegGSGLCYTPADRCNNQKSCPDGADEKNC 452
Cdd:cd00112    1 CPPNEFRC--ANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 277-362 1.50e-04

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 41.61  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125   277 PSDLHCTWLVDTQDSRRVLLQ---LELRLGYD---DYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAaqGRLTVAYHAR 350
Cdd:smart00042  13 PNNLDCVWTIRAPPGYRIELQftdFDLESSDNceyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS--NSLTLTFVSD 90

                           90
                   ....*....|..
gi 167555125   351 ARSAGHGFNATY 362
Cdd:smart00042  91 SSVQKRGFSARY 102
CUB pfam00431
CUB domain;
254-362 5.89e-04

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 39.97  E-value: 5.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125  254 CGRRLGSFYGSFASPDlfGAARGPSDLHCTWLVDTQDSRRVLLQ---LEL---RLGYDDYVQVYEGLGERGDRLlqtLSY 327
Cdd:pfam00431   1 CGGVLTDSSGSISSPN--YPNPYPPNKDCVWLIRAPPGFRVKLTfqdFELedhDECGYDYVEIRDGPSASSPLL---GRF 75

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 167555125  328 RSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATY 362
Cdd:pfam00431  76 CGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
PHA03247 PHA03247
large tegument protein UL36; Provisional
 615-757 6.12e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125  615 PRAPRGQIPLLTAARPSQTVLGDgflQPAPGAAPDPPAPLMDTGSTRAAGDRPPSAPGRAPEVGPSGPPLPSglrDPECR 694
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWD---PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPS---LPLGG 2854

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 167555125  695 PVDKDRKVCREPLVDGPAPADA-PREPCSAQDPHPQV--STASSTLGPHSPEPLgvcRNPPPPCSP 757
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPAaPARPPVRRLARPAVsrSTESFALPPDQPERP---PQPQAPPPP 2917
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 664-757 1.01e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.75  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125 664 GDRPPSA----PGRAPEVG--PSGPPLPSGLRDPEC-----RPVDKDRKVCREP-----LVDGPAPADAPREPCSAQDPH 727
Cdd:PTZ00449 558 GKKPGPAkehkPSKIPTLSkkPEFPKDPKHPKDPEEpkkpkRPRSAQRPTRPKSpklpeLLDIPKSPKRPESPKSPKRPP 637

                         90       100       110
                 ....*....|....*....|....*....|
gi 167555125 728 PQVSTASstlgPHSPEPLGVCRNPPPPCSP 757
Cdd:PTZ00449 638 PPQRPSS----PERPEGPKIIKSPKPPKSP 663
PHA03247 PHA03247
large tegument protein UL36; Provisional
 546-762 2.19e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125  546 RREAPPSYGQLIAQGLIPPVEDfPVYSASQASVLQNLRTAMRRQMRRHASRRGPSRRRLGRLWNRLFH--------RPRA 617
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDPPPPS-PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQassppqrpRRRA 2687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125  618 PRGQI-PLLTAARP---------------SQTVLGDGFLQPAPGAAPDPPAPLMDTGSTRAAGDRPPSAPGRAPevGPSG 681
Cdd:PHA03247 2688 ARPTVgSLTSLADPppppptpepaphalvSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPP--TTAG 2765

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125  682 PPLPSGLRDPECRPVDKDRKVCREPLVDG----PAPADAPREPCSAQDPHPQVSTASSTLGPhSPEPLGVCRNPPPPCSP 757
Cdd:PHA03247 2766 PPAPAPPAAPAAGPPRRLTRPAVASLSESreslPSPWDPADPPAAVLAPAAALPPAASPAGP-LPPPTSAQPTAPPPPPG 2844


                  ....*
gi 167555125  758 MLEAS 762
Cdd:PHA03247 2845 PPPPS 2849
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 658-762 2.33e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 41.09  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555125 658 GSTRAAGDRPPSAPGRAPEVGPSGPPLPSGLRdPECRPVDKDRKVCREPLVDGPAPADAPrePCSAQDPHPQVSTASSTL 737
Cdd:PHA03291 178 GEGSADGSCDPALPLSAPRLGPADVFVPATPR-PTPRTTASPETTPTPSTTTSPPSTTIP--APSTTIAAPQAGTTPEAE 254

                         90       100
                 ....*....|....*....|....*
gi 167555125 738 GPHSPEPLGVCRNPPPPCSPMLEAS 762
Cdd:PHA03291 255 GTPAPPTPGGGEAPPANATPAPEAS 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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