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Conserved domains on  [gi|4505049|ref|NP_002337|]
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lymphocyte antigen 6E precursor [Homo sapiens]

Protein Classification

Ly-6/uPAR domain-containing protein; Ly-6/uPAR domain-containing protein; acrosomal protein SP-10; acrosomal protein SP-10( domain architecture ID 10639047)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2); LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2); acrosomal protein SP-10 (ACRV1) is a testis-specific, intra-acrosomal protein that is associated with the membranes and matrix of the acrosomal vesicle; acrosomal protein SP-10 (ACRV1) is a testis-specific, intra-acrosomal protein that is associated with the membranes and matrix of the acrosomal vesicle

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 19-99 9.09e-32

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467073  Cd Length: 78  Bit Score: 107.44  E-value: 9.09e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505049   19 SSLMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSASAGIGNlvTFGHSLSKTCSPACPIpEGVNVGVASMGISCCQSFLC 98
Cdd:cd23543   1 HSLYCYTCENQSSNWNCLKPTKCSDNDKYCVTTVASGGTGS--SSGVRITKKCSPKCPE-TNVNIGIASVSTSCCQSSLC 77


                .
gi 4505049   99 N 99
Cdd:cd23543  78 N 78
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 19-99 9.09e-32

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 107.44  E-value: 9.09e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505049   19 SSLMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSASAGIGNlvTFGHSLSKTCSPACPIpEGVNVGVASMGISCCQSFLC 98
Cdd:cd23543   1 HSLYCYTCENQSSNWNCLKPTKCSDNDKYCVTTVASGGTGS--SSGVRITKKCSPKCPE-TNVNIGIASVSTSCCQSSLC 77


                .
gi 4505049   99 N 99
Cdd:cd23543  78 N 78
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-105 1.34e-14

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 64.09  E-value: 1.34e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505049      21 LMCFSCLNQkSNLYCLKPTICSDQDNYCVTVSASAGIGNlvtFGHSLSKTC--SPACPIPEG--VNVGVASMGISCCQSF 96
Cdd:smart00134   1 LQCYSCTGN-PDSSCSSEEECRSPDDVCLTVVAEVISDS---RGSVVYKGCatSPICPGSHGyeINLTIAFLKVSCCQTD 76


                   ....*....
gi 4505049      97 LCNFSAADG 105
Cdd:smart00134  77 LCNAAGPGA 85
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 23-99 9.76e-14

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 61.79  E-value: 9.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505049     23 CFSCLNQkSNLYCLKPTICSDQDNYCVTVSASAGIGNLvtFGHSLSKTCS-PACPIPE--GVNVGVASMGISCCQSFLCN 99
Cdd:pfam00021   1 CYSCLGV-SNEDCLSEVTCPLSDGQCVTTTLELPEGNL--RGTVVSKGCArSSCPRLLsdFINGGIISVSESCCQSDLCN 77
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 19-99 9.09e-32

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 107.44  E-value: 9.09e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505049   19 SSLMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSASAGIGNlvTFGHSLSKTCSPACPIpEGVNVGVASMGISCCQSFLC 98
Cdd:cd23543   1 HSLYCYTCENQSSNWNCLKPTKCSDNDKYCVTTVASGGTGS--SSGVRITKKCSPKCPE-TNVNIGIASVSTSCCQSSLC 77


                .
gi 4505049   99 N 99
Cdd:cd23543  78 N 78
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 20-103 2.69e-16

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 68.51  E-value: 2.69e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505049   20 SLMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSASAGIGNLVTfgHSLSKTCSPACPiPEGVNVGVASMGISCCQSFLCN 99
Cdd:cd23575   2 SLKCYTCVSAHSNSDCLTETNCSSSDTYCKTLVASASGGSGSL--TTITKWCASSCT-PSTRTVEGTKVTVSCCQTDLCN 78


                ....
gi 4505049  100 FSAA 103
Cdd:cd23575  79 VSGA 82
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-105 1.34e-14

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 64.09  E-value: 1.34e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505049      21 LMCFSCLNQkSNLYCLKPTICSDQDNYCVTVSASAGIGNlvtFGHSLSKTC--SPACPIPEG--VNVGVASMGISCCQSF 96
Cdd:smart00134   1 LQCYSCTGN-PDSSCSSEEECRSPDDVCLTVVAEVISDS---RGSVVYKGCatSPICPGSHGyeINLTIAFLKVSCCQTD 76


                   ....*....
gi 4505049      97 LCNFSAADG 105
Cdd:smart00134  77 LCNAAGPGA 85
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 23-99 9.76e-14

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 61.79  E-value: 9.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505049     23 CFSCLNQkSNLYCLKPTICSDQDNYCVTVSASAGIGNLvtFGHSLSKTCS-PACPIPE--GVNVGVASMGISCCQSFLCN 99
Cdd:pfam00021   1 CYSCLGV-SNEDCLSEVTCPLSDGQCVTTTLELPEGNL--RGTVVSKGCArSSCPRLLsdFINGGIISVSESCCQSDLCN 77
TFP_LU_ECD_PSCA cd23573
extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; ...
 19-102 2.67e-07

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467103  Cd Length: 78  Bit Score: 45.13  E-value: 2.67e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505049   19 SSLMCFSCLNQKSNLYCLKPTICSDQDNYCVTvsasaGIGNLVTFGHSLSKTCSPACpIPEGVNVGVASMGISCCQSFLC 98
Cdd:cd23573   1 GSLQCYTCKAQLSNSNCQTETPCRENAKACKT-----DVIRAVGLLKVISKECSSSC-TEDYQDYFVGKRNITCCSTDLC 74


                ....
gi 4505049   99 NFSA 102
Cdd:cd23573  75 NVNG 78
Toxin_TOLIP pfam00087
Snake toxin and toxin-like protein; This family predominantly includes venomous neurotoxins ...
 21-99 2.02e-04

Snake toxin and toxin-like protein; This family predominantly includes venomous neurotoxins and cytotoxins from snakes, but also structurally similar (non-snake) toxin-like proteins (TOLIPs) such as Lymphocyte antigen 6D and Ly6/PLAUR domain-containing protein. Snake toxins are short proteins with a compact, disulphide-rich structure. TOLIPs have similar structural features (abundance of spaced cysteine residues, a high frequency of charge residues, a signal peptide for secretion and a compact structure) but, are not associated with a venom gland or poisonous function. They are endogenous animal proteins that are not restricted to poisonous animals.


Pssm-ID: 395040  Cd Length: 70  Bit Score: 37.21  E-value: 2.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4505049     21 LMCFSCLNQKSnlyCLKPTICSDQDNYCVTVSASAgignlVTFGHSLSKTCSPACPIpEGVNVGVASMGISCCQSFLCN 99
Cdd:pfam00087   1 LRCHNCAAAGN---CVQPETCQDNTRYCLTLWNSP-----PGHRTHVIKGCAYTCPV-TQESLNISRASDCCCETDLCN 70
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 21-99 6.48e-04

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 36.14  E-value: 6.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505049   21 LMCFSClNQKSNLYCLKPTICSDQDNYCVTVSASAGIGNLVtfghsLSKTCSPACPIPEGVNVGVAS---------MGIS 91
Cdd:cd23550   1 LTCHVC-EVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFL-----VSKQCSKYCPVVEVPPPPPKSfvlekpmpfLYIK 74


                ....*...
gi 4505049   92 CCQSFLCN 99
Cdd:cd23550  75 CCRENLCN 82
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 18-99 8.97e-04

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 35.85  E-value: 8.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505049   18 ASSLMCFSClnqKSNLYCLKPTICSDQDNYCVTVSASAGIGNLVTfghslsKTCSPACPIPEgvNVGVASMGIS---CCQ 94
Cdd:cd23542   3 ANALQCHVC---NSSSNCTNPVNCEGSERYCKTTTVVQPSGNLVK------KGCAETCPPST--SRQQVGSGISsvtCCQ 71


                ....*
gi 4505049   95 SFLCN 99
Cdd:cd23542  72 GDLCN 76
TFP_LU_ECD_SLURP1_like cd23560
extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like ...
 21-99 5.02e-03

extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like family; The SLURP-1-like family includes SLURP-1 and Ly6/PLAUR domain-containing protein 2 (LYPD2). SLURP-1 (also called ARS component B, or ARS (component B)-81/S, or anti-neoplastic urinary protein (ANUP)) has an antitumor activity. It was found to be a marker of late differentiation of the skin. It is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro SLURP-1 down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells SLURP-1 may be involved in regulation of intracellular Ca(2+) signaling. It may also have an immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation. LYPD2 is a lymphocyte antigen-6 family protein and shows high sequence similarity with SLURP-1. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467090  Cd Length: 78  Bit Score: 33.96  E-value: 5.02e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4505049   21 LMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSASAGIGNLVTFGHSLSKTCSPACpIPEGVNVGVASMGISCCQSFLCN 99
Cdd:cd23560   1 LRCYTCPEPTDSSLCTTIVNCSPNETACKTTLYSVDSGYPFFGNITVTRGCASEC-IPSDPDGIGETHPISCCNTDLCN 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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