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Conserved domains on  [gi|166064062|ref|NP_002546|]
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solute carrier family 22 member 18 isoform b [Homo sapiens]

Protein Classification

solute carrier family 22 member 18( domain architecture ID 13023744)

solute carrier family 22 member 18 is a major facilitator superfamily (MFS) transporter that may function as an organic cation/proton antiporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 25-413 6.01e-131

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 381.95  E-value: 6.01e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  25 VILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYL 104
Cdd:cd17331    1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 105 LLAAAsspalPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPA 184
Cdd:cd17331   81 LLAFA-----SSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 185 ILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPraSVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSII 264
Cdd:cd17331  156 LVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPP--SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 265 SMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCT 344
Cdd:cd17331  234 AMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSV 313

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 166064062 345 LNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 413
Cdd:cd17331  314 LYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
 
Name Accession Description Interval E-value
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 25-413 6.01e-131

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 381.95  E-value: 6.01e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  25 VILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYL 104
Cdd:cd17331    1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 105 LLAAAsspalPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPA 184
Cdd:cd17331   81 LLAFA-----SSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 185 ILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPraSVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSII 264
Cdd:cd17331  156 LVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPP--SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 265 SMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCT 344
Cdd:cd17331  234 AMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSV 313

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 166064062 345 LNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 413
Cdd:cd17331  314 LYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-373 1.81e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 88.88  E-value: 1.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  18 SALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFL 97
Cdd:COG2814    4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  98 AALALYLLLaaassPALPGVYLLFASRLPGALMHTL--PAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLV 175
Cdd:COG2814   84 LFALGSLLC-----ALAPSLWLLLAARFLQGLGAGAlfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 176 SAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAplpggprasvfdlkAIASLLRLPDVPRIFLVKVASNCPTG 255
Cdd:COG2814  159 DLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG--------------SLRELLRRPRLLLLLLLAFLLGFGFF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 256 LFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLV 335
Cdd:COG2814  225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLAL 303

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 166064062 336 PGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQ 373
Cdd:COG2814  304 FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
MFS_1 pfam07690
Major Facilitator Superfamily;
26-381 6.06e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 69.37  E-value: 6.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062   26 ILLTYVLAATELTCLFmqFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLL 105
Cdd:pfam07690   1 LFLAAFLAALGRSLLG--PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  106 LAAAsspalPGVYLLFASRLPGALMH--TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcp 183
Cdd:pfam07690  79 LLFA-----SSLWLLLVLRVLQGLGAgaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR-- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  184 ailaaLATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSI 263
Cdd:pfam07690 152 -----AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  264 isMDFFQLEAAQAGYLMSFFGLLqMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLV---F 340
Cdd:pfam07690 227 --QEVLGLSALLAGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLllgF 303

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 166064062  341 SLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGP 381
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 25-413 6.01e-131

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 381.95  E-value: 6.01e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  25 VILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYL 104
Cdd:cd17331    1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 105 LLAAAsspalPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPA 184
Cdd:cd17331   81 LLAFA-----SSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 185 ILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPraSVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSII 264
Cdd:cd17331  156 LVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPP--SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 265 SMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCT 344
Cdd:cd17331  234 AMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSV 313

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 166064062 345 LNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 413
Cdd:cd17331  314 LYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 30-413 2.07e-53

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 181.62  E-value: 2.07e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  30 YVLAATELTCLFMQFSIVPYLSR---KLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLL 106
Cdd:cd17330    2 FLVVFLDALGFGIVFPVLPFYVRefnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 107 AAasspALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAIL 186
Cdd:cd17330   82 GL----SRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 187 AalatllgavlsftcipastkgaktdaqaplpggprASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISM 266
Cdd:cd17330  158 A-----------------------------------AALALLNLVLVLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLK 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 267 DFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLN 346
Cdd:cd17330  203 DRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVF 282

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 166064062 347 VVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 413
Cdd:cd17330  283 PALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 30-415 3.51e-29

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 116.56  E-value: 3.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  30 YVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAA 109
Cdd:cd17390    2 YLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 110 SSpalpgVYLLFASRLP-GALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGiqcpailaa 188
Cdd:cd17390   82 TS-----LALLFLSRIPlGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDG--------- 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 189 latlLGAVLSFTCipastkgaktdaqaplpggprASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDF 268
Cdd:cd17390  148 ----GFYYVALLC---------------------SAIFILNAGLVWFLLSKLWDLLLVRFLMGFSVLLFRSNFSLYLEER 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 269 FQLEAAQAGYLMSFFGLLQMVTQGLV--IGQLSSHFSEEVLLRASVLVFIVVgLAMAWMSSVFHFCLLVPGLVFSLCTLN 346
Cdd:cd17390  203 FDLSPKTIGYLISYSGVLGALSGFLVgrILKLYKNNEYLLLLHSFILLALSL-LGLALAPSIWLLVLCLTPLSISSAVLR 281

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 166064062 347 VVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYrSFGVPVFGHVQVAINTLVLLVLWRKP 415
Cdd:cd17390  282 TCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQ-EFSVSGPGLLGAVLALAAILLMLARQ 349
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 42-394 5.56e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 90.71  E-value: 5.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  42 MQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALpgvyLLF 121
Cdd:cd17325   14 IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ----LLL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 122 ASRLPGALMH-TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFT 200
Cdd:cd17325   90 ARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 201 CIPASTKGAKTdaqaplpgGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLM 280
Cdd:cd17325  170 LLPEPRPPPNK--------RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 281 SFFGLLQMVTQGLViGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTS 360
Cdd:cd17325  242 GAQGLASALSQPPA-GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320

                        330       340       350
                 ....*....|....*....|....*....|....
gi 166064062 361 DTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVP 394
Cdd:cd17325  321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA 354
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-373 1.81e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 88.88  E-value: 1.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  18 SALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFL 97
Cdd:COG2814    4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  98 AALALYLLLaaassPALPGVYLLFASRLPGALMHTL--PAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLV 175
Cdd:COG2814   84 LFALGSLLC-----ALAPSLWLLLAARFLQGLGAGAlfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 176 SAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAplpggprasvfdlkAIASLLRLPDVPRIFLVKVASNCPTG 255
Cdd:COG2814  159 DLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG--------------SLRELLRRPRLLLLLLLAFLLGFGFF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 256 LFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLV 335
Cdd:COG2814  225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLAL 303

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 166064062 336 PGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQ 373
Cdd:COG2814  304 FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 25-416 1.99e-14

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 74.21  E-value: 1.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  25 VILLTYVLAATELTcLFMqfSIVPYLSRKLGLDSIA----FGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAAL 100
Cdd:cd17388    3 FILVTVLLDAMGIG-LIM--PVLPTLLREFVGDSADaathYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 101 ALYLLLAAAsspalPGVYLLFASRLPGALM-HTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGtLVSAYG 179
Cdd:cd17388   80 LDYLLMAFA-----PTLWWLYLGRIIAGITgATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGG-LLGEIS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 180 IQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVprIFLVKVASNCPtglfMV 259
Cdd:cd17388  154 PRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAV--FFLIQLIGQVP----AT 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 260 MFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLR----ASVLVFIVVGLA-MAWMSsvfhFCLL 334
Cdd:cd17388  228 TWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILlglaADALGFLLLAFAtQGWMV----FPIL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 335 VPGLVFSLCTlnVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQV--AINTLVLLVLW 412
Cdd:cd17388  304 ILLALGGIAG--PALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIigAALYLICLVLA 381


                 ....
gi 166064062 413 RKPM 416
Cdd:cd17388  382 YRFF 385
MFS_1 pfam07690
Major Facilitator Superfamily;
26-381 6.06e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 69.37  E-value: 6.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062   26 ILLTYVLAATELTCLFmqFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLL 105
Cdd:pfam07690   1 LFLAAFLAALGRSLLG--PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  106 LAAAsspalPGVYLLFASRLPGALMH--TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcp 183
Cdd:pfam07690  79 LLFA-----SSLWLLLVLRVLQGLGAgaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR-- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  184 ailaaLATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSI 263
Cdd:pfam07690 152 -----AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  264 isMDFFQLEAAQAGYLMSFFGLLqMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLV---F 340
Cdd:pfam07690 227 --QEVLGLSALLAGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLllgF 303

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 166064062  341 SLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGP 381
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 30-388 1.34e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 65.53  E-value: 1.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  30 YVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAa 109
Cdd:cd06174    2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 110 sspaLPGVYLLFASRLPGALMHTL--PAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIqcpaILA 187
Cdd:cd06174   81 ----APSFWLLLLGRFLLGLGSGLidPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF----GWR 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 188 ALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMD 267
Cdd:cd06174  153 AVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 268 FFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNV 347
Cdd:cd06174  233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLP 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 166064062 348 VTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLY 388
Cdd:cd06174  313 LSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
46-420 1.62e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 56.04  E-value: 1.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  46 IVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAasspaLPGVYLLFASRL 125
Cdd:COG2223   27 LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLAL-----AVSYWLLLLLGL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 126 PGALMH--TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIP 203
Cdd:COG2223  102 LLGIGGggSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLR 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 204 ASTKGAKTDAQAPlpggprasvfdLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFF 283
Cdd:COG2223  182 DPPAGAAAAAKAS-----------LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALF 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 284 GLLQMVTqGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTL-NVVTDSMLIKAVSTSDT 362
Cdd:COG2223  251 ALLGALG-RPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGgNGAVFALVPDIFPTKNA 329

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 166064062 363 GTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFG-HVQVAINTLVLLVLWRKPMPQRK 420
Cdd:COG2223  330 GAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAfLVFAVLALVALVLTLLLYRRPRR 388
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
46-420 1.29e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.34  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  46 IVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAAsspalPGVYLLFASRL 125
Cdd:COG2271   32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA-----TSFWQLLLLRF 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 126 PGALMH--TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIqcpailaalatllgavlsftcip 203
Cdd:COG2271  107 LLGLGEagFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW----------------------- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 204 astkgaktdaqaplpggpRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFF 283
Cdd:COG2271  164 ------------------RAAFLILGLPGLLLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLP 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 284 GLLQMVTqGLVIGQLSSHFSEE--VLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSD 361
Cdd:COG2271  226 FLAGIVG-SLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA 304

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 166064062 362 TGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWRKPMPQRK 420
Cdd:COG2271  305 RGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 57-414 2.75e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 52.23  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  57 DSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTL--P 134
Cdd:cd06173   32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFfgP 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 135 AAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPastkgakTDAQ 214
Cdd:cd06173  112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRR-------PPPA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 215 APLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGlLQMVTQGLV 294
Cdd:cd06173  185 APGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFG-VGALLGALL 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 295 IGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQP 374
Cdd:cd06173  264 LGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNS 343

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 166064062 375 LLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWRK 414
Cdd:cd06173  344 GAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_1 pfam07690
Major Facilitator Superfamily;
243-424 1.40e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 46.64  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  243 IFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEEVLLRASVLVFIVVGLAM 322
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  323 AWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVA 402
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180
                  ....*....|....*....|..
gi 166064062  403 INTLVLLVLWRKPMPQRKDKVR 424
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPK 181
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 133-413 1.63e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 46.79  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 133 LPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVsAYGIQCPAILAALATLLGAVLSFTCIPastkgaktd 212
Cdd:cd17474  105 GPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLP--------- 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 213 aqAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQG 292
Cdd:cd17474  175 --EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSL 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 293 LVIGQLSSHFSEEVLLRASVLVFivvGLAMAWMSSVFHFCLLVPGLVFS---LCTLNVVTDSMLIKAVSTSDTGTMLGLC 369
Cdd:cd17474  253 FVGRLLKKRFGARRILVIGLLLY---ALSLLLLGFVPSLALLLIAIVLFglgLGLNLPLLTTLVTELAPEEERGTASSLY 329

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 166064062 370 ASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 413
Cdd:cd17474  330 NFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 49-392 2.28e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.07  E-value: 2.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  49 YLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASrLPGA 128
Cdd:cd17329   25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTG-FGGG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 129 LMHtlPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVsAYGIQCPAILAALATLLGAVLSFTCIPASTKG 208
Cdd:cd17329  104 LFE--PASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLPETRPK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 209 AKTDAQAPLPGGPRASVFDlkaiasllrlpdvpRIFLvkvasncptgLFMVMFSIISMDFFQLE--------------AA 274
Cdd:cd17329  181 RRAAEKTEILRGYKIVLRD--------------RAFL----------LFLLASFLISLIYFQLEstlpvyvveilglgES 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 275 QAGYLMSFFGLLQMVTQGLVIGqLSSHFSEEVLLRASVLV----FIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTD 350
Cdd:cd17329  237 LLGLLLALNALLIVLLQFPVAR-LVERFRLRKILMIGILLfaigFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVA 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 166064062 351 SMLIKAvstsDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFG 392
Cdd:cd17329  316 ALAPPD----KRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG 353
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 32-396 5.73e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 44.88  E-value: 5.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  32 LAATELTCLFMQ---FSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAA 108
Cdd:cd17504    1 LALAALAVMLVEtmlSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 109 AsspalPGVYLLFASR-LPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcpaila 187
Cdd:cd17504   81 A-----PNLPVLIAGRaLQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWR------ 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 188 alatllgaVLSFTCIPASTKGAktdAQAPLpggprasvFDLKaiasLLRLPDVPRIFLVKVASNcpTGLFMVMFSIISM- 266
Cdd:cd17504  150 --------WIFWTAAPVAVLLA---ALVPL--------IDLR----LLRRRNVLLANITALLAG--FGMFMVFQLLPQLl 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 267 -----DFFQLEAAQAGYLMSFFGLLQMVTqGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMA---WMSSVFHFCLLVPGL 338
Cdd:cd17504  205 qlptpTGFGLGITEAGLLLLPGALVMLIA-GPLAGRLIARVGPRRVLLIGLVISAVGLLLLAllhSSLWALVVALLLIGI 283

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 166064062 339 VFSLCTLNVVTdsMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVF 396
Cdd:cd17504  284 GLGLAFASLPN--IVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSIT 339
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
7-163 7.55e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.58  E-value: 7.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062   7 PRDQGRSPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVP-YLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQ 85
Cdd:COG2814  190 PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPlYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR 269

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 166064062  86 RGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASrlpGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVG 163
Cdd:COG2814  270 FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLG---FGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
254-413 9.59e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.19  E-value: 9.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 254 TGLFMVMFSIISMDFfQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCL 333
Cdd:COG2814   26 IGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 334 LVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 413
Cdd:COG2814  104 ARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLR 183
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
24-181 1.03e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.09  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  24 SVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALY 103
Cdd:COG2271  181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAL 260

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 166064062 104 LLLAAASSPALPGVYLLFAsrLPGALMH-TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQ 181
Cdd:COG2271  261 ALLLLALLPSPALAIALLF--LAGFGLGgAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 25-414 2.64e-04

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 42.97  E-value: 2.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  25 VILLTYVLAATELTCLFMqfSIVPYLSrKLGLDSIA--FGYLQTTFGVLQLLGGPVFGRFADQRG-ARAALTLSFLAALA 101
Cdd:cd17326    3 VMYLTMFLSSLQFSIVLT--SIWPYLQ-KIDPTATAsfFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 102 LYLLLAAASSPALPGVYLLFASR-LPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVsaygi 180
Cdd:cd17326   80 GNILYALAEYFPSNRKYVMLVARfLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFT----- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 181 qcpailaalatllgavlsftciPASTKGAKTDAQAPL-----PGGPRASVFDLKAIASLLRLPDVPRIFlVKVASNCPTG 255
Cdd:cd17326  155 ----------------------PIGYPGYVIGIKLRFnmytaPAWLMAILGIINIILILFFFKEVVCIF-LFFVVLFIFA 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 256 LFMVMFSIISMDFFQLEAAQA----GYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLamawMSSVFHF 331
Cdd:cd17326  212 NLETIGTPLTMDMYGWTREEAvlynGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFV----VTLPWGI 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 332 CL-LVPGLVFSLCtlNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFG-VPVFGH--VQVAINTLV 407
Cdd:cd17326  288 TGvILFGLGYPIG--NVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGpRWTWIItlGLLLLAIIL 365


                 ....*..
gi 166064062 408 LLVLWRK 414
Cdd:cd17326  366 LIVFYKR 372
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 15-179 2.73e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 42.92  E-value: 2.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  15 GRMSALGRSSVILLTYVLAATELTCLFMQFS-IVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALT 93
Cdd:cd17324  189 SSLLLLLRNPRLRLAYLITFLLFGGFFALYTyLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  94 LSFLAALALYLLLAAASSPALPGVYLLFASrlpGALMHTLPAAQMVITDLsAPEERPAALGRLGLCFGVGVILGSLLGGT 173
Cdd:cd17324  269 ALLLLAAALLLLTLLGPSPLLLLVGLVLWG---LGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGL 344


                 ....*.
gi 166064062 174 LVSAYG 179
Cdd:cd17324  345 VLDHGG 350
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 13-295 4.52e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 41.72  E-value: 4.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  13 SPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAAL 92
Cdd:COG0477    3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  93 TLSFLAALALYLLLAaasspALPGVYLLFASR----LPGALMhtLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGS 168
Cdd:COG0477   83 LIGLLLFGLASLLCG-----LAPSPELLIAARalqgIGAGGL--MPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 169 LLGGTLVSAYGIQCPAILAALATLLGAVLSFTcIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKV 248
Cdd:COG0477  156 LLGGLLVAALGWRWIFLINAPLGLLALVLRLR-LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLL 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 166064062 249 ASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQGLVI 295
Cdd:COG0477  235 AGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLL 281
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 45-179 1.63e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 40.30  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062  45 SIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADqRGARAALTLSFLAALALYLLLAaassPALPGVYLLFASR 124
Cdd:cd17328   20 GVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGD-RYNRKWILAVGILIWSAATLLS----SFAPNFWQLLLFR 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 125 lpgALMHT-----LPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYG 179
Cdd:cd17328   95 ---ALVGIgeasySPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG 151
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
146-412 5.63e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.73  E-value: 5.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 146 PEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcPAILAALATLLGAVLSFTCIPASTKGAKtdaQAPLPGGPRASV 225
Cdd:COG2211  142 YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGD-AALGYRLTALIFAVLGLLAFLLTFFGTK---ERPVPEEEKVSL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 226 FDlkAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEE 305
Cdd:COG2211  218 KE--SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA-PLWPRLAKRFGKK 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166064062 306 VLLRASVLVFIVVGLAMAWM--SSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAV-------STSDTGTMLGLCASVQPLL 376
Cdd:COG2211  295 KAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFTFAIKLG 374

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 166064062 377 RTLGPTVGGLLYRSFG-VPVFGHVQVAINTLVLLVLW 412
Cdd:COG2211  375 QALAGALAGLLLALFGyVAGAAQSPSALTGIRLLFFL 411
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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