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Conserved domains on  [gi|4505545|ref|NP_002549|]
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P2X purinoceptor 1 [Homo sapiens]

Protein Classification

P2X purinoceptor( domain architecture ID 10017488)

P2X purinoceptor consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P2X TIGR00863
cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC ...
1-368 0e+00

cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]


:

Pssm-ID: 273307  Cd Length: 372  Bit Score: 643.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545      1 MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSS-GLISSVSVKLKGLAVTQLPG 79
Cdd:TIGR00863   1 MARRLAAGLSSFFFDYKTPKYVLVRNKKVGVIYRLVQLLILVYVIGWVFLAEKGYQESDtSPQSSVITKVKGVAVTQTSE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545     80 LGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEG--GICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVK 157
Cdd:TIGR00863  81 LGNRVWDVADYVKPPQGENVFFVMTNFIVTPNQTQGRCPEHPSVplAICWSDSDCTAGEAGTHGNGIKTGRCVPFNGTVK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545    158 TCEIFGWCPVEvDDDIPRPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQ 237
Cdd:TIGR00863 161 TCEIFAWCPVE-VDTVPSPPLLKEAENFTLFIKNSIRFPKFNFSKRNILETWDATYLKTCLFDPDSDPYCPIFRLGDIVE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545    238 ESGQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLY-EEKNLSPGFNFRFARHFVEN-GTNYRHLFKVFGIRF 315
Cdd:TIGR00863 240 EAGQDFQDLALKGGVVGITINWDCDLDKAASHCNPKYSFRRLDnKEKNVSPGYNFRFAKYYRDNaGVETRTLLKAYGIRF 319
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 4505545    316 DILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKF 368
Cdd:TIGR00863 320 DILVTGKAGKFDIIPTMITIGSGLASLGVGTFLCDLILLYFMKKRHFYRDKKF 372
 
Name Accession Description Interval E-value
P2X TIGR00863
cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC ...
1-368 0e+00

cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273307  Cd Length: 372  Bit Score: 643.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545      1 MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSS-GLISSVSVKLKGLAVTQLPG 79
Cdd:TIGR00863   1 MARRLAAGLSSFFFDYKTPKYVLVRNKKVGVIYRLVQLLILVYVIGWVFLAEKGYQESDtSPQSSVITKVKGVAVTQTSE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545     80 LGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEG--GICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVK 157
Cdd:TIGR00863  81 LGNRVWDVADYVKPPQGENVFFVMTNFIVTPNQTQGRCPEHPSVplAICWSDSDCTAGEAGTHGNGIKTGRCVPFNGTVK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545    158 TCEIFGWCPVEvDDDIPRPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQ 237
Cdd:TIGR00863 161 TCEIFAWCPVE-VDTVPSPPLLKEAENFTLFIKNSIRFPKFNFSKRNILETWDATYLKTCLFDPDSDPYCPIFRLGDIVE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545    238 ESGQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLY-EEKNLSPGFNFRFARHFVEN-GTNYRHLFKVFGIRF 315
Cdd:TIGR00863 240 EAGQDFQDLALKGGVVGITINWDCDLDKAASHCNPKYSFRRLDnKEKNVSPGYNFRFAKYYRDNaGVETRTLLKAYGIRF 319
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 4505545    316 DILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKF 368
Cdd:TIGR00863 320 DILVTGKAGKFDIIPTMITIGSGLASLGVGTFLCDLILLYFMKKRHFYRDKKF 372
P2X_receptor pfam00864
ATP P2X receptor;
14-370 0e+00

ATP P2X receptor;


Pssm-ID: 459968  Cd Length: 362  Bit Score: 563.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545     14 FEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSGLISSVSVKLKGLAVTQLPGLGPQVWDVADYVFP 93
Cdd:pfam00864   1 FDYETPKVVVIRSKKVGLIYRLVQLLILGYIIGWVFVYEKGYQEKDTVVSSVTTKVKGVAVTNVSDYGIRVWDVADYVIP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545     94 AQGDNSFVVMTNFIVTPKQTQGYCAEHPEGG-ICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDD 172
Cdd:pfam00864  81 PQGENVFFVMTNLIVTPNQTQGTCPESPDGKpNCTSDQDCGAGEGKPVGNGIQTGRCVPFNWTTKTCEIFGWCPVELDTA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545    173 IPRPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFSTLAEKGGV 252
Cdd:pfam00864 161 PPFPPLLKNAENFTVFIKNSIRFPKFNFSRRNILPQYDKTYLKTCTYHPLTDPYCPIFRLGDIVAEAGENFSELANKGGV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545    253 VGITIDWHCDLDWHVRHCRPIYEFHGLYE---EKNLSPGFNFRFARHFVE-NGTNYRHLFKVFGIRFDILVDGKAGKFDI 328
Cdd:pfam00864 241 IGIKINWDCDLDSDRSHCNPKYSFRRLDGknfNNAVSPGYNFRFAKYYKEkNGVERRTLIKAYGIRFDIIVFGKAGKFSI 320
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 4505545    329 IPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKY 370
Cdd:pfam00864 321 IPTIINIGSGLALLGVATVLCDLILLYFLKKREFYYDKKFEE 362
 
Name Accession Description Interval E-value
P2X TIGR00863
cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC ...
1-368 0e+00

cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273307  Cd Length: 372  Bit Score: 643.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545      1 MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSS-GLISSVSVKLKGLAVTQLPG 79
Cdd:TIGR00863   1 MARRLAAGLSSFFFDYKTPKYVLVRNKKVGVIYRLVQLLILVYVIGWVFLAEKGYQESDtSPQSSVITKVKGVAVTQTSE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545     80 LGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEG--GICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVK 157
Cdd:TIGR00863  81 LGNRVWDVADYVKPPQGENVFFVMTNFIVTPNQTQGRCPEHPSVplAICWSDSDCTAGEAGTHGNGIKTGRCVPFNGTVK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545    158 TCEIFGWCPVEvDDDIPRPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQ 237
Cdd:TIGR00863 161 TCEIFAWCPVE-VDTVPSPPLLKEAENFTLFIKNSIRFPKFNFSKRNILETWDATYLKTCLFDPDSDPYCPIFRLGDIVE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545    238 ESGQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLY-EEKNLSPGFNFRFARHFVEN-GTNYRHLFKVFGIRF 315
Cdd:TIGR00863 240 EAGQDFQDLALKGGVVGITINWDCDLDKAASHCNPKYSFRRLDnKEKNVSPGYNFRFAKYYRDNaGVETRTLLKAYGIRF 319
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 4505545    316 DILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKF 368
Cdd:TIGR00863 320 DILVTGKAGKFDIIPTMITIGSGLASLGVGTFLCDLILLYFMKKRHFYRDKKF 372
P2X_receptor pfam00864
ATP P2X receptor;
14-370 0e+00

ATP P2X receptor;


Pssm-ID: 459968  Cd Length: 362  Bit Score: 563.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545     14 FEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSGLISSVSVKLKGLAVTQLPGLGPQVWDVADYVFP 93
Cdd:pfam00864   1 FDYETPKVVVIRSKKVGLIYRLVQLLILGYIIGWVFVYEKGYQEKDTVVSSVTTKVKGVAVTNVSDYGIRVWDVADYVIP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545     94 AQGDNSFVVMTNFIVTPKQTQGYCAEHPEGG-ICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDD 172
Cdd:pfam00864  81 PQGENVFFVMTNLIVTPNQTQGTCPESPDGKpNCTSDQDCGAGEGKPVGNGIQTGRCVPFNWTTKTCEIFGWCPVELDTA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545    173 IPRPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFSTLAEKGGV 252
Cdd:pfam00864 161 PPFPPLLKNAENFTVFIKNSIRFPKFNFSRRNILPQYDKTYLKTCTYHPLTDPYCPIFRLGDIVAEAGENFSELANKGGV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505545    253 VGITIDWHCDLDWHVRHCRPIYEFHGLYE---EKNLSPGFNFRFARHFVE-NGTNYRHLFKVFGIRFDILVDGKAGKFDI 328
Cdd:pfam00864 241 IGIKINWDCDLDSDRSHCNPKYSFRRLDGknfNNAVSPGYNFRFAKYYKEkNGVERRTLIKAYGIRFDIIVFGKAGKFSI 320
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 4505545    329 IPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKY 370
Cdd:pfam00864 321 IPTIINIGSGLALLGVATVLCDLILLYFLKKREFYYDKKFEE 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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